uracil has been researched along with Chemical and Drug Induced Liver Injury in 21 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study the therapeutic effect and metabolism of 5-FU and its masked compounds: FT, UFT (uracil + FT), HCFU (Carmofur), 5'-DFUR (Doxifluridine) were assessed by using MOPC-104E plasmacytoma transplanted subcutaneously in BALB/c mice with CCl4-induced chronic liver dysfunction." | 3.68 | [Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction]. ( Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M, 1990) |
| "Hepatic decompensation and acute liver failure are rare but severe complications of Ritonavir-boosted Paritaprevir, Ombitasvir and Dasabuvir plus Ribavirin therapy in patients with compensated cirrhosis." | 1.43 | A Case of Acute Liver Failure during Ritonavir-Boosted Paritaprevir, Ombitasvir and Dasabuvir Therapy in a Patient with HCV Genotype 1b Cirrhosis. ( Andreone, P; Magalotti, D; Martino, E; Masetti, M; Scuteri, A; Zoli, M, 2016) |
| "Uracil was previously shown by us to be the active principle of Trionyx carapax." | 1.29 | Effect of pretreatment of rats with uracil on liver injuries induced by D-galactosamine and allyl alcohol. ( Ariyoshi, T; Kitajima, S; Ogawa, N, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Saad, MA | 1 |
| Rastanawi, AA | 1 |
| El-Yamany, MF | 1 |
| Kumar, R | 1 |
| Hsiang, JC | 1 |
| Tan, J | 1 |
| Thurairajah, PH | 1 |
| Masetti, M | 1 |
| Magalotti, D | 1 |
| Martino, E | 1 |
| Andreone, P | 1 |
| Scuteri, A | 1 |
| Zoli, M | 1 |
| Kawasaki, A | 1 |
| Mimatsu, K | 1 |
| Kuboi, Y | 1 |
| Kano, H | 1 |
| Oida, T | 1 |
| Amano, S | 1 |
| Sudo, C | 1 |
| Maekawa, K | 1 |
| Segawa, K | 1 |
| Hanatani, T | 1 |
| Sai, K | 1 |
| Saito, Y | 1 |
| LEEVY, CM | 1 |
| TEN-HOVE, W | 1 |
| FRANK, O | 1 |
| BAKER, H | 1 |
| Churmantaeva, SKh | 1 |
| Ueno, Y | 1 |
| Ueno, I | 1 |
| Ito, K | 1 |
| Tatsuno, T | 1 |
| Kobayashi, F | 1 |
| Ikeda, T | 1 |
| Sakamoto, N | 1 |
| Kurosaki, M | 1 |
| Tozuka, S | 1 |
| Sakamoto, S | 1 |
| Fukuma, T | 1 |
| Marumo, F | 1 |
| Sato, C | 1 |
| Kitajima, S | 2 |
| Ogawa, N | 2 |
| Ariyoshi, T | 2 |
| Suzuki, K | 1 |
| Nukui, A | 1 |
| Kobayashi, M | 1 |
| Sugaya, Y | 1 |
| Muraishi, O | 1 |
| Morita, T | 1 |
| Tokue, A | 1 |
| Silaeva, SA | 1 |
| Golenchenko, VA | 1 |
| Gavril'chak, AV | 1 |
| Onufriev, MV | 1 |
| Khatsernova, BI | 1 |
| Guliaeva, NV | 1 |
| Shekhter, AB | 1 |
| Tsubono, M | 2 |
| Nio, Y | 2 |
| Imai, S | 2 |
| Shiraishi, T | 2 |
| Morimoto, H | 2 |
| Tseng, CC | 2 |
| Kawabata, K | 1 |
| Fukumoto, M | 1 |
| Tobe, T | 2 |
| Aoike, A | 1 |
| Hosokawa, T | 1 |
| Koyama, K | 1 |
| Rokutan, K | 1 |
| Nishi, Y | 1 |
| Yoshida, A | 1 |
| Nakamura, K | 1 |
| Kawai, K | 1 |
| Vitlin, VI | 1 |
| Decker, K | 2 |
| Keppler, D | 2 |
| Rudigier, J | 1 |
| Domschke, W | 1 |
| Bischoff, E | 1 |
| Liersch, M | 1 |
| Reznik, ND | 1 |
| Goriacheva, LA | 1 |
2 reviews available for uracil and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
[A case of pulmonary metastasis from renal cell carcinoma with complete response to interferon-alpha and tegafur/uracil (UFT) but possibly UFT-induced liver dysfunction and leukoencephalopathy-like symptoms].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Carcinoma, Renal Cell; Chemical and | 1999 |
[Use of pentoxyl and methyluracil (methacil) in liver diseases (literature review)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Humans; Liver Diseases; Liver R | 1971 |
19 other studies available for uracil and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Apoptosis; Autophagy; Be | 2018 |
Ombitasvir/paritaprevir/ritonavir+dasabuvir and ribavirin associated drug-induced liver injury and syndrome of inappropriate secretion of anti-diuretic hormone: A case report.
Topics: 2-Naphthylamine; Anilides; Antiviral Agents; Carbamates; Chemical and Drug Induced Liver Injury; Cre | 2019 |
A Case of Acute Liver Failure during Ritonavir-Boosted Paritaprevir, Ombitasvir and Dasabuvir Therapy in a Patient with HCV Genotype 1b Cirrhosis.
Topics: 2-Naphthylamine; Aged, 80 and over; Anilides; Antiviral Agents; Ascites; Carbamates; Chemical and Dr | 2016 |
[Drug-induced liver injury associated with uracil/tegafur + folinate therapy].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and | 2009 |
[Trends in drug-induced liver injury based on reports of adverse reactions to PMDA in Japan].
Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Anti-Inflammatory Agents; Antineopla | 2012 |
FOLIC ACID DEFICIENCY AND HEPATIC DNA SYNTHESIS.
Topics: Avitaminosis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; Folic Aci | 1964 |
[Metabolic disorders and their correction in petrochemical production workers exposed to heptyl].
Topics: Adult; Antidotes; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical Industry; Fuel Oils | 2003 |
Impairments of RNA synthesis in Ehrlich ascites tumour by luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp.
Topics: Animals; Anthraquinones; Antimetabolites; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Nucleus; C | 1967 |
Severe chronic active hepatitis induced by UFTR containing tegafur and uracil.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Chemic | 1995 |
Effect of pretreatment of rats with uracil on liver injuries induced by D-galactosamine and allyl alcohol.
Topics: 1-Propanol; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Li | 1994 |
Protective effect of Trionyx carapax on CCl4-induced hepatic injury is mediated by uracil.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1994 |
[Effect of carnosine and 4-methyluracil on the development of experimental hepatitis in rats].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Carnosine; Chemical and Drug Induced | 1992 |
Low uracil concentration in the liver might be responsible for the decreased antineoplastic activity of fluoropyrimidines in mice with CCl4-induced chronic liver dysfunction.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Resistance; Fi | 1991 |
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride | 1990 |
[Effect of fluoropyrimidine, drugs of tegafur and UFT on transplanted tumor in liver-damaged mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical an | 1988 |
Cell damage by trapping of biosynthetic intermediates. The role of uracil nucleotides in experimental hepatitis.
Topics: Alanine Transaminase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Hepatitis; | 1971 |
Fate of intravenously administered UDPglucose.
Topics: Animals; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Female; Glucose; Glucuronates; Hep | 1970 |
[Clinical assessment of the efficacy of methyluracil in chronic hepatitis of chemico-toxic etiology].
Topics: Adult; Benzene Derivatives; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; | 1969 |