Page last updated: 2024-10-20

uracil and Cancer of Prostate

uracil has been researched along with Cancer of Prostate in 37 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Research Excerpts

ExcerptRelevanceReference
"To determine whether long-term oral administration of UFT, a combination of 5-fluorouracil and uracil, in addition to conventional estrogen therapy improved the response and survival of the patients with advanced stage D2 prostate adenocarcinoma, a randomized prospective study was performed with either estrogen alone (Honvan 200 mg/day or presexol 1 mg/day: group A) or estrogen plus UFT (400 mg/day:group B)."5.08[Combination therapy with estrogen and UFT in newly diagnosed prostatic cancer (poorly differentiated, stage D2)]. ( Fujii, H; Fukushima, S; Harada, M; Hosaka, M; Kondo, I; Kubota, Y; Miura, T, 1996)
" UFT (a compound of tegafur and uracil) is said to be effective for bladder cancer."4.80[Progress in oral anti-cancer drug therapy for urological cancer]. ( Akaza, H; Tsukamoto, S, 1999)
"This prospective and randomized clinical study was initiated to compare the efficacy and safety of combined androgen blockade with combination with UFT in patients with untreated prostate cancer."2.70Prospective and randomized comparison of combined androgen blockade versus combination with oral UFT as an initial treatment for prostate cancer. ( Kuriyama, M; Ohshima, S; Ono, Y; Sahashi, M; Shimizu, H; Takahashi, Y; Tanaka, T, 2001)
"In the study of bladder cancer, neither a significant difference of non-recurrent rate nor of survival rate was seen between the two groups."2.69[Effect of UFT on treatment of urological cancer--effect of UFT on treatment of invasive bladder cancer and advanced prostate cancer. Ibaraki Urological Cancer Chemotherapy Study Group]. ( Akaza, H; Hattori, K; Ishikawa, S; Kawai, K; Kikuchi, K; Kobayashi, T; Koiso, K; Kondo, F; Manabe, F; Matsuki, K; Miyanaga, N; Noguchi, R; Shimazui, T; Suzuki, R; Takeshima, H; Tsuchiya, A; Uchida, K, 1998)
"To evaluate the efficacy of chemoendocrine therapy for the initial treatment of stage D2 prostate cancer, we conducted a prospective randomized study which compared combined androgen blockade alone to that combined with UFT."2.69[Primary treatment for stage D2 prostate cancer: a randomized study of combined androgen blockade alone versus combined with UFT]. ( Akazawa, S; Aki, M; Hashine, K; Kuwahara, M; Sumiyoshi, Y; Takenaka, A; Yamamoto, A, 1999)
"Of the 136 patients with prostate cancer enrolled in this study from April 1990 to December 1992, 69 received endocrine plus UFT therapy and the remaining 67 received endocrine-only therapy."2.69Endocrine plus uracil/tegafur therapy for prostate cancer. ( Kawada, Y; Kuriyama, M; Ohshima, S; Ono, Y; Shimizu, H; Takahashi, Y, 1999)
"We evaluated the usefulness of hormonal therapy combined with UFT as initial treatment in comparison with hormonal therapy alone in 92 patients with Stage D2 prostatic cancer treated at the Department of Urology, Dokkyo University School of Medicine between 1974 and 1993."2.68[Clinical evaluation of chemohormonal therapy as an initial treatment for stage D2 prostatic cancer--effect of UFT administration combined with hormonal therapy]. ( Chen, JA; Honda, M; Hosoya, Y; Imai, T; Maeda, S; Suzuki, T; Takasaki, E, 1995)
"Although prostate cancer initially responds well to endocrine therapy, it becomes resistant to the therapy a few years later, and is called hormone-refractory cancer."1.31[Long-term survival of hormone-refractory prostate cancer: a case report]. ( Fujimoto, N; Harada, S; Hida, T; Matsumoto, T, 2001)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19906 (16.22)18.7374
1990's16 (43.24)18.2507
2000's9 (24.32)29.6817
2010's5 (13.51)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Spisz, P1
Kozak, W1
Chomicz-Mańka, L1
Makurat, S1
Falkiewicz, K1
Sikorski, A1
Czaja, A1
Rak, J1
Zdrowowicz, M1
Pulukuri, SM1
Knost, JA1
Estes, N1
Rao, JS1
Kawaguchi, T1
Mayama, I1
Iwabuchi, I1
Ogasawara, M1
Tsukui, A1
Hatano, K1
Nonomura, N3
Nishimura, K4
Kawashima, A1
Mukai, M1
Nagahara, A1
Nakai, Y2
Nakayama, M1
Takayama, H1
Tsujimura, A1
Okuyama, A3
Shimasaki, T1
Miyazawa, K1
Moriyama, M1
Tanaka, T2
Sato, I1
Nakaya, N1
Nakajima, H1
Kubo, A1
Suzuki, K1
Motoo, Y1
Kume, H1
Gamagedara, S1
Kaczmarek, AT1
Jiang, Y1
Cheng, X2
Rupasinghe, M1
Ma, Y1
Hoshi, S2
Ohyama, C2
Namiki, S1
Hagisawa, S2
Satoh, M2
Saito, S2
Ono, K2
Shirasaka, T1
Arai, Y4
Shimizu, K1
Tokizane, T1
Inoue, H1
Takaha, N2
Kamoi, K1
Ukimura, O1
Miki, T2
Koide, T1
Ichikawa, Y1
Sugao, H2
Yamaguchi, S1
Takatera, H1
Uchida, K4
Miura, H1
Fukuzaki, A1
Schinazi, RF1
Hurwitz, SJ1
Liberman, I1
Glazkova, Y1
Mourier, NS1
Olson, J1
Keane, T1
Bhandari, MS1
Pienta, KJ1
Fardig, J1
Olson, K1
Smith, DC1
Masuda, F1
Tashiro, K1
Machida, T1
Shida, K1
Yamanaka, H2
Ito, Y2
Shimazaki, J1
Isaka, S1
Yokokawa, M1
Fukui, I1
Kawai, H1
Akimoto, M1
Yoshida, K1
Maekawa, T1
Kashihara, N1
Tsujita, M1
Morikawa, Y1
Hayahara, N1
Nishijima, T1
Ezaki, K1
Senju, M1
Iritani, M1
Yamaguchi, M1
Honda, M1
Takasaki, E1
Suzuki, T1
Maeda, S2
Imai, T1
Hosoya, Y1
Chen, JA1
Hayashi, T2
Shiga, T1
Hattori, K2
Nishijima, Y2
Kasaya, S1
Shimazui, T2
Akaza, H4
Koiso, K3
Nemoto, R2
Sakai, H1
Minami, Y1
Kanetake, H1
Saito, Y1
Fujita, K4
Matsushima, H1
Nakano, M1
Kaneko, T1
Kasaya, T1
Harada, M2
Kondo, I1
Miura, T1
Fujii, H1
Fukushima, S1
Kubota, Y1
Hosaka, M1
Satake, H1
Fujioka, A1
Uchida, J1
Takeda, S1
Unemi, N1
Yee, LK1
Chu, E1
Pan, BC1
Chu, SH1
Chen, TM1
Lipsky, MH1
Chu, MY1
Calabresi, P1
Takeshima, H1
Kikuchi, K1
Miyanaga, N1
Kawai, K1
Tsuchiya, A1
Noguchi, R1
Manabe, F1
Matsuki, K1
Suzuki, R1
Ishikawa, S1
Kondo, F1
Kobayashi, T1
Tsukamoto, S1
Sumiyoshi, Y1
Hashine, K1
Kuwahara, M1
Aki, M1
Yamamoto, A1
Akazawa, S1
Takenaka, A1
Ono, Y3
Ohshima, S2
Takahashi, Y3
Kuriyama, M3
Kawada, Y2
Shimizu, H2
Nozawa, M1
Fukui, T1
Harada, Y1
Imazu, T1
Sahashi, M1
Fujimoto, N1
Harada, S1
Hida, T1
Matsumoto, T1
Munakata, A1
Shinoda, I1
Takeuchi, T1
Ban, Y1
Yamamoto, N1
Tada, K1
Imai, K1
Mashimo, T1
Yuasa, H1
Yoshida, M1
Asano, M1
Fukuzaki, H1
KumaKura, M1
Sakamoto, S1
Kusuyama, H1
Numa, H1
Okada, K1
Kagawa, S1
Takigawa, H1
Aga, Y1
Kurokawa, K1
Naito, K1
Hisazumi, H1
Misaki, T1
Shimada, K1
Miyazaki, K1
Kosaka, S1
Miyagi, T1
Murayama, T1
Sayama, T1
Abe, S1

Reviews

2 reviews available for uracil and Cancer of Prostate

ArticleYear
[Hormonal chemotherapy for hormone-refractory prostate cancer].
    Hinyokika kiyo. Acta urologica Japonica, 2002, Volume: 48, Issue:11

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Proto

2002
[Progress in oral anti-cancer drug therapy for urological cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:3

    Topics: Administration, Oral; Androgen Antagonists; Antineoplastic Agents, Hormonal; Drug Administration Sch

1999

Trials

12 trials available for uracil and Cancer of Prostate

ArticleYear
[Hormonal chemotherapy for hormone-refractory prostate cancer].
    Hinyokika kiyo. Acta urologica Japonica, 2002, Volume: 48, Issue:11

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Proto

2002
Phase II trial of oral uracil/tegafur plus leucovorin in patients with hormone-refractory prostate carcinoma.
    Cancer, 2006, Apr-15, Volume: 106, Issue:8

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemot

2006
[Endocrine chemotherapy for prostatic cancer].
    Hinyokika kiyo. Acta urologica Japonica, 1994, Volume: 40, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chlormadinone Acetate; Follow-Up Studies; Humans; Ma

1994
[Clinical evaluation of chemohormonal therapy as an initial treatment for stage D2 prostatic cancer--effect of UFT administration combined with hormonal therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:1

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Mo

1995
Chemo-endocrine therapy for prostate cancer with bone metastasis. Nagasaki Prostate Cancer Research Group.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35 Suppl

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone

1994
[Combination therapy with estrogen and UFT in newly diagnosed prostatic cancer (poorly differentiated, stage D2)].
    Hinyokika kiyo. Acta urologica Japonica, 1996, Volume: 42, Issue:3

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Diethylstil

1996
[Effect of UFT on treatment of urological cancer--effect of UFT on treatment of invasive bladder cancer and advanced prostate cancer. Ibaraki Urological Cancer Chemotherapy Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:8

    Topics: Administration, Oral; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents; Antineop

1998
[Primary treatment for stage D2 prostate cancer: a randomized study of combined androgen blockade alone versus combined with UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:8

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Antimetabolites, Antineoplastic; Anti

1999
Endocrine plus uracil/tegafur therapy for prostate cancer.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:7 Suppl 3

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Ch

1999
Oral combination of cyclophosphamide, uracil plus tegafur and estramustine for hormone-refractory prostate cancer.
    Oncology, 2001, Volume: 60, Issue:1

    Topics: Administration, Oral; Aged; Aged, 80 and over; Androgen Antagonists; Antimetabolites, Antineoplastic

2001
Prospective and randomized comparison of combined androgen blockade versus combination with oral UFT as an initial treatment for prostate cancer.
    Japanese journal of clinical oncology, 2001, Volume: 31, Issue:1

    Topics: Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Pr

2001
Fundamental study on the implantable LH-RH agonist/polymer and its use in a randomized trial for prostate cancer.
    Progress in clinical and biological research, 1990, Volume: 357

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Implants; Drug Screening Assays, Antit

1990

Other Studies

24 other studies available for uracil and Cancer of Prostate

ArticleYear
5-(
    International journal of molecular sciences, 2020, Sep-01, Volume: 21, Issue:17

    Topics: Antineoplastic Agents; Cell Survival; Cells, Cultured; Crystallography, X-Ray; Dermis; DNA; Fibrobla

2020
Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress.
    Molecular cancer research : MCR, 2009, Volume: 7, Issue:8

    Topics: Apoptosis; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; DNA Damage; Doxorubicin; Gene Ex

2009
[Chemo-endocrine therapy with low-dose cisplatin, UFT, and dexamethasone for hormone-refractory prostate cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:10

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dexamethasone; G

2010
Retrospective analysis of an oral combination of dexamethasone, uracil plus tegafur and cyclophosphamide for hormone-refractory prostate cancer.
    Japanese journal of clinical oncology, 2011, Volume: 41, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combi

2011
[Combination chemotherapy of docetaxel and UFT against hormone refractory prostate cancer].
    Hinyokika kiyo. Acta urologica Japonica, 2011, Volume: 57, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Doce

2011
[Oral antineoplastic agents for prostate cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69 Suppl 5

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combine

2011
Validation study of urinary metabolites as potential biomarkers for prostate cancer detection.
    Bioanalysis, 2012, Volume: 4, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Case-Control Studies; Chromatography,

2012
[Low-dose cisplatin and UFT for hormone refractory prostate cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:10

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Com

2002
Complete regression of bone metastases on super bone scan, by low-dose cisplatin, UFT, diethylstilbestrol diphosphate, and dexamethasone in a patient with hormone-refractory prostate cancer.
    International journal of clinical oncology, 2003, Volume: 8, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bio

2003
Tissue disposition of 5-o-carboranyluracil--a novel agent for the boron neutron capture therapy of prostate cancer.
    Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:1-2

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Humans; Male; Mice; Mice, Nude; Organ Speci

2004
[Clinical effect of UFT on urogenital tumors].
    Hinyokika kiyo. Acta urologica Japonica, 1984, Volume: 30, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone an

1984
[Phase II study of UFT for malignant tumors of urinary organs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Comb

1984
[Treatment of prostatic carcinoma with UFT and leucovorin--basic study using SRCA].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:15

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Humans; Leucovorin; Male; Mice; Mice, Inbre

1994
[Ifosfamide in combined hormonochemotherapy on prostate cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone

1994
[Subrenal capsule assay of nude mice for testing the effectiveness of UFT for rat prostatic carcinoma (R3327)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Male; Mice; Mice, I

1993
[Inhibition of prostate cancer growth in nude mice by hormone and chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:10

    Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Diethylsti

1996
Benzylacyclouridine enhances 5-fluorouracil cytotoxicity against human prostate cancer cell lines.
    Pharmacology, 1998, Volume: 56, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Inter

1998
[Long-term survival of hormone-refractory prostate cancer: a case report].
    Journal of UOEH, 2001, Mar-01, Volume: 23, Issue:1

    Topics: Adenocarcinoma; Administration, Oral; Aged; Androgen Antagonists; Chlormadinone Acetate; Combined Mo

2001
[Experience of oral hormone-chemotherapy in prostatic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:10

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cyclo

1991
[Studies on 5-FU concentration in serum and prostate cancer tissue after oral administration of UFT].
    Hinyokika kiyo. Acta urologica Japonica, 1991, Volume: 37, Issue:7

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Male; Pr

1991
[Lung metastases of prostatic cancer vanished by early combined hormonal and chemotherapy: report of a case].
    Hinyokika kiyo. Acta urologica Japonica, 1989, Volume: 35, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality T

1989
[Experimental study of UFT in prostatic carcinoma (DU-145) in nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line; Cells, Cultured; Hu

1986
[Clinical effect of UFT on prostatic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:7

    Topics: Adenocarcinoma; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Hum

1985
[A trial of hormonochemotherapy of prostate cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Diethylstilbestrol; Humans;

1985