uracil has been researched along with Cancer of Gastrointestinal Tract in 39 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
Excerpt | Relevance | Reference |
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"For prevention of the chemotherapy-induced stomatitis we administered allopurinol mouthwash to 15 out of 38 patients who underwent PMUE regimen." | 7.68 | [Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies]. ( Anada, E; Fujimura, T; Fujita, H; Haryo, S; Sawasaki, K; Shima, Y; Shiota, S, 1991) |
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
"For prevention of the chemotherapy-induced stomatitis we administered allopurinol mouthwash to 15 out of 38 patients who underwent PMUE regimen." | 3.68 | [Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies]. ( Anada, E; Fujimura, T; Fujita, H; Haryo, S; Sawasaki, K; Shima, Y; Shiota, S, 1991) |
" In total, 79 courses were administered with a median of 3 (range 1-6)." | 2.72 | UFT in combination with oxaliplatin: clinical phase I study in patients with advanced or metastatic solid tumors. ( Abad, A; Aranda, E; Carrato, A; Díaz-Rubio, E; Gallego, J; Gómez, A; López, E; Manzano, JL; Sastre, J, 2006) |
" There was also an increase in plasma uracil and unmetabolised 18F-fluorouracil and an increase in the radiotracer half-life in tumours (2." | 2.69 | Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action. ( Aboagye, EO; Brady, F; Jones, T; Lucas, SV; Osman, S; Price, PM; Saleem, A; Suttle, B; Yap, J, 2000) |
"Fifty of 80 cases had advanced gastric cancer, 30 had pancreatic cancer or other cancers, such as colon cancer, and biliary tract cancer." | 2.66 | [Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki Cooperative Study Group of Cancer Chemotherapy]. ( Baba, T; Furukohori, N; Itoh, T; Kawata, K; Kimura, T; Munakata, A; Saitoh, S; Sakata, Y; Suzuki, H; Tamura, Y, 1988) |
"Trifluridine/tipiracil is an oral chemotherapeutic agent recently approved for third-line treatment of chemorefractory metastatic colorectal cancer." | 2.58 | Trifluridine/tipiracil: an emerging strategy for the management of gastrointestinal cancers. ( Cervantes, A; Moreno Vera, S; Peeters, M; Taieb, J, 2018) |
" The thymidine analog trifluorothymidine (TFT) has been shown to bypass resistance pathways for 5FU derivatives (S-1, UFT, Xeloda) in model systems, while concurrent application with a thymidine phosphorylase inhibitor (TPI) increases the bioavailability of TFT, thereby potentiating the in vivo efficacy of TFT." | 2.44 | Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies. ( de Bruin, M; Emura, T; Fukushima, M; Peters, GJ; Temmink, OH, 2007) |
"8% of DPYD variant carriers died due to FP-TOX compared to 0% in the group receiving DPYD genotype-guided dosing of FP." | 1.91 | Implementation and clinical benefit of DPYD genotyping in a Danish cancer population. ( Bergmann, TK; Damkier, P; Ewertz, M; Feddersen, S; Fruekilde, PBN; Holm, HS; Paulsen, NH; Pfeiffer, P; Qvortrup, C, 2023) |
" Potential predictive pharmacokinetic parameters and pharmacodynamic biomarkers have been found." | 1.38 | Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers. ( Allegrini, G; Arrighi, G; Barletta, MT; Bocci, G; Brandi, G; Canu, B; Chericoni, S; Ciarlo, A; Danesi, R; Di Desidero, T; Di Paolo, A; Falcone, A; Fioravanti, A; Fontana, A; Giusiani, M; Kerbel, RS; Loupakis, F; Lucchesi, S; Masi, G; Orlandi, P, 2012) |
"Thirty four patients with advanced gastric cancer (GC), colon cancer (CC) biliary tract cancer (BC) and pancreatic cancer (PC) were treated with a combined chemotherapy of UFT with ADM (UFT-A), or UFT with ADM and CDDP (UFT-AC)." | 1.28 | [Combination chemotherapy of UFT with adriamycin (ADM) and cisplatin (CDDP) for advanced gastrointestinal cancer]. ( Koda, K; Kure, T; Matsunaga, T; Miyazaki, E; Morii, K; Morita, K; Nakajima, K; Nakazawa, O; Terada, S; Tsuji, Y, 1990) |
"Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients." | 1.27 | Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity. ( Gall, H; Kraal, I; Lankelma, J; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ, 1984) |
" Total Ftorafur (FT) results using the same criteria from the UFT phase II study revealed, from a comparison of dosage and disease type, that UFT did not enhance FT side effects; rather, it markedly increases effectiveness." | 1.27 | [Report on nationwide pooled data and cohort investigation in UFT phase II study]. ( Kimura, K; Ota, K; Taguchi, T, 1987) |
"Ten patients with carcinomatous peritonitis of gastrointestinal cancer have been treated with administrations of CDDP-Ip (50-150 mg/body), in combination with systemic chemotherapy simultaneously combined with sodium thiosulfate (STS) iv in 4 patients." | 1.27 | [Intraperitoneal (Ip) administration of cisplatin in combination with systemic chemotherapy in patients with malignant ascites of gastrointestinal cancer: clinical evaluation and pharmacokinetics]. ( Fukushi, A; Hirayama, M; Koda, K; Kure, T; Morita, K; Nakazawa, O; Takahashi, H; Terada, S; Terui, T; Yoshizaki, N, 1988) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (23.08) | 18.7374 |
1990's | 11 (28.21) | 18.2507 |
2000's | 11 (28.21) | 29.6817 |
2010's | 6 (15.38) | 24.3611 |
2020's | 2 (5.13) | 2.80 |
Authors | Studies |
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Paulsen, NH | 1 |
Pfeiffer, P | 1 |
Ewertz, M | 1 |
Fruekilde, PBN | 1 |
Feddersen, S | 1 |
Holm, HS | 1 |
Bergmann, TK | 1 |
Qvortrup, C | 1 |
Damkier, P | 1 |
Hernando-Cubero, J | 1 |
Matos-García, I | 1 |
Alonso-Orduña, V | 1 |
Capdevila, J | 1 |
Peeters, M | 1 |
Cervantes, A | 1 |
Moreno Vera, S | 1 |
Taieb, J | 1 |
Cunha-Junior, GF | 2 |
De Marco, L | 1 |
Bastos-Rodrigues, L | 1 |
Bolina, MB | 1 |
Martins, FL | 1 |
Pianetti, GA | 2 |
Cesar, IC | 2 |
Coelho, LG | 1 |
Hayatsu, H | 1 |
Duarte Byrro, RM | 1 |
Vaz Coelho, LG | 1 |
Allegrini, G | 1 |
Di Desidero, T | 1 |
Barletta, MT | 1 |
Fioravanti, A | 1 |
Orlandi, P | 1 |
Canu, B | 1 |
Chericoni, S | 1 |
Loupakis, F | 1 |
Di Paolo, A | 1 |
Masi, G | 1 |
Fontana, A | 1 |
Lucchesi, S | 1 |
Arrighi, G | 1 |
Giusiani, M | 1 |
Ciarlo, A | 1 |
Brandi, G | 1 |
Danesi, R | 1 |
Kerbel, RS | 1 |
Falcone, A | 1 |
Bocci, G | 1 |
Morimoto, S | 1 |
Mishima, H | 1 |
Tsujinaka, T | 1 |
Kawato, N | 1 |
Shono, Y | 1 |
Tsuji, T | 2 |
Tabuse, K | 1 |
Nakata, I | 1 |
Saito, M | 1 |
Uenaka, K | 1 |
Yip, D | 1 |
Karapetis, C | 1 |
Strickland, AH | 1 |
Steer, C | 1 |
Holford, C | 1 |
Knight, S | 1 |
Harper, P | 1 |
Yamada, Y | 1 |
Hamaguchi, T | 1 |
Goto, M | 1 |
Muro, K | 1 |
Matsumura, Y | 1 |
Shimada, Y | 1 |
Shirao, K | 1 |
Nagayama, S | 1 |
Saad, ED | 1 |
Hoff, PM | 1 |
Byström, P | 1 |
Frödin, JE | 1 |
Berglund, A | 1 |
Wilking, N | 1 |
Glimelius, B | 1 |
Sastre, J | 1 |
Aranda, E | 1 |
Abad, A | 1 |
Gallego, J | 1 |
Manzano, JL | 1 |
Gómez, A | 1 |
Carrato, A | 1 |
López, E | 1 |
Díaz-Rubio, E | 1 |
Temmink, OH | 1 |
Emura, T | 1 |
de Bruin, M | 1 |
Fukushima, M | 1 |
Peters, GJ | 2 |
Leyva, A | 1 |
van Groeningen, CJ | 1 |
Kraal, I | 1 |
Gall, H | 1 |
Lankelma, J | 1 |
Pinedo, HM | 1 |
Seo, Y | 1 |
Matsuoka, H | 1 |
Kakeji, Y | 1 |
Morita, M | 1 |
Ohno, S | 1 |
Matsukuma, A | 1 |
Tomoda, H | 1 |
Furusawa, M | 1 |
Nakamura, M | 1 |
Katano, M | 1 |
Yunotani, S | 1 |
Hisatsugu, T | 1 |
Sasadomi, E | 1 |
Masumoto, H | 1 |
Tsuji, Y | 2 |
Yoshihito, H | 1 |
Nakamura, T | 1 |
Watanabe, Y | 1 |
Nakayama, N | 1 |
Ohi, M | 1 |
Kawanishi, J | 1 |
Handa, H | 1 |
Honjo, K | 1 |
Uehara, S | 1 |
Horikoshi, N | 1 |
Aiba, K | 1 |
Kanamaru, R | 1 |
Hasegawa, K | 1 |
Takeda, S | 2 |
Taguchi, T | 3 |
Niitani, H | 1 |
Furue, H | 1 |
Kurihara, M | 1 |
Ogawa, M | 1 |
Abe, T | 2 |
Duley, JA | 1 |
Nethersell, AB | 1 |
Oki, E | 1 |
Sakaguchi, Y | 1 |
Toh, Y | 1 |
Oda, S | 1 |
Maehara, Y | 2 |
Yamamoto, N | 1 |
Sugimachi, K | 2 |
Blanke, CD | 1 |
Teng, M | 1 |
Choy, H | 1 |
Saleem, A | 2 |
Yap, J | 1 |
Osman, S | 2 |
Brady, F | 1 |
Suttle, B | 1 |
Lucas, SV | 1 |
Jones, T | 1 |
Price, PM | 2 |
Aboagye, EO | 2 |
Saltz, L | 1 |
Cunningham, VJ | 1 |
Basaki, Y | 1 |
Miyadera, K | 1 |
Yonekura, K | 1 |
Aoyagi, K | 1 |
Chikahisa, L | 1 |
Okabe, S | 1 |
Hashimoto, A | 1 |
Kitazato, K | 1 |
Bulay, O | 1 |
Mirvish, SS | 1 |
Garcia, H | 1 |
Pelfrene, AF | 1 |
Gold, B | 1 |
Eagen, M | 1 |
Fujimura, T | 1 |
Shima, Y | 1 |
Sawasaki, K | 1 |
Haryo, S | 1 |
Fujita, H | 1 |
Anada, E | 1 |
Shiota, S | 1 |
Koda, K | 2 |
Nakazawa, O | 2 |
Morita, K | 2 |
Kure, T | 2 |
Terada, S | 2 |
Matsunaga, T | 1 |
Miyazaki, E | 1 |
Nakajima, K | 1 |
Morii, K | 1 |
Kikuchi, K | 1 |
Wakui, A | 1 |
Seki, H | 1 |
Takahashi, H | 2 |
Kimura, K | 2 |
Ota, K | 1 |
Hirayama, M | 1 |
Fukushi, A | 1 |
Terui, T | 1 |
Yoshizaki, N | 1 |
Misawa, S | 1 |
Yashige, H | 1 |
Nishigaki, H | 1 |
Horiike, S | 1 |
Tsuda, S | 1 |
Takino, T | 1 |
Taniwaki, M | 1 |
Anai, H | 1 |
Kusumoto, H | 1 |
Kusumoto, T | 1 |
Sakata, Y | 1 |
Munakata, A | 1 |
Baba, T | 1 |
Saitoh, S | 1 |
Itoh, T | 1 |
Tamura, Y | 1 |
Furukohori, N | 1 |
Suzuki, H | 1 |
Kimura, T | 1 |
Kawata, K | 1 |
Kosarev, VA | 1 |
Nikiforov, AM | 1 |
8 reviews available for uracil and Cancer of Gastrointestinal Tract
Article | Year |
---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
The Role of Fluoropirimidines in Gastrointestinal Tumours: from the Bench to the Bed.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocol | 2017 |
Trifluridine/tipiracil: an emerging strategy for the management of gastrointestinal cancers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Clinical Trials as Topic; | 2018 |
UFT and oral leucovorin as radiation sensitizers in rectal and other gastrointestinal malignancies.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Gas | 2003 |
Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Biological Availability; Clinical Trials as T | 2007 |
[Gastrointestinal cancer and oral anticancer agents].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Drug Com | 1999 |
The role of UFT in combined-modality therapy.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as To | 1999 |
Perspectives on fluorinated pyrimidine use in gastrointestinal and breast oncology.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Fluorine Compounds; Gastrointestinal Neoplasms; Hum | 2001 |
9 trials available for uracil and Cancer of Gastrointestinal Tract
Article | Year |
---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Phase I study of UFT plus leucovorin with radiotherapy in patients with inextirpable non-rectal gastrointestinal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Follow-Up | 2004 |
UFT in combination with oxaliplatin: clinical phase I study in patients with advanced or metastatic solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, | 2006 |
[Low-dose FP (5-FU+low-dose CDDP) therapy for far advanced upper gastro-intestinal carcinoma].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuva | 1995 |
[Outpatient chemotherapy with continuous infusion of 5-fluorouracil (CI 5-FU) and intravenous bolus leucovorin (IVB LV) in advanced gastrointestinal cancer: the second report].
Topics: Administration, Oral; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Chemoth | 1995 |
[Phase I study of orally administered UFT plus l-leucovorin].
Topics: Administration, Oral; Adolescent; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protoc | 1998 |
Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NAD | 2000 |
[Cooperative research of UFT E phase II study. Cooperative Study Group of UFT E in Tohoku Area].
Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; | 1990 |
[Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki Cooperative Study Group of Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Clinical Trials as Top | 1988 |
23 other studies available for uracil and Cancer of Gastrointestinal Tract
Article | Year |
---|---|
Implementation and clinical benefit of DPYD genotyping in a Danish cancer population.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Denmark; Dihydropyrimidine Dehydrogenase Deficiency; | 2023 |
(13)C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Breath Tests; Carbon Isotopes; Dihy | 2013 |
Re: Analysis of fecal DNA methylation to detect gastrointestinal neoplasia.
Topics: Cathartics; Cytosine; DNA Methylation; False Positive Reactions; Feces; Gastrointestinal Neoplasms; | 2010 |
A rapid HPLC-ESI-MS/MS method for determination of dihydrouracil/uracil ratio in plasma: evaluation of toxicity to 5-flurouracil in patients with gastrointestinal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liqui | 2012 |
Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cyclophosphamide | 2012 |
[Combined determination of urine uracil levels and plasma 5-FU clearance for a simple order-made treatment with anticancer agents of FU derivative].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Screening Ass | 2003 |
A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols | 2003 |
Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemothe | 2003 |
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Topics: Adult; Aged; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, P | 1984 |
[Pharmacodynamic study on the effectiveness of UFT against cancer of gastro-intestinal (GI) tract].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Fluorouracil; Gast | 1993 |
Delayed hypersensitivity to 5-fluorouracil associated with reduced dihydropyrimidine dehydrogenase (DPD) activity.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Creatinine; Dihydrouracil Dehydrogenase (NADP | 1998 |
Induction of apoptosis in human tumour xenografts after oral administration of uracil and tegafur to nude mice bearing tumours.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma; Cell Division; Colonic Neoplasms; Ga | 1998 |
Extraction of 5-fluorouracil by tumor and liver: a noninvasive positron emission tomography study of patients with gastrointestinal cancer.
Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorine Rad | 2001 |
[Gamma-hydroxybutyric acid, a metabolite of UFT, shows anti-angiogenic activities and antitumor effect].
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Drug Combinations; Endothelial Growth Facto | 2002 |
Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats.
Topics: Administration, Oral; Animals; Benzamides; Carcinogens; Drug Evaluation, Preclinical; Female; Gastro | 1979 |
[Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies].
Topics: Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Female; Gastroint | 1991 |
[Combination chemotherapy of UFT with adriamycin (ADM) and cisplatin (CDDP) for advanced gastrointestinal cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Cisplatin; Col | 1990 |
[Concentration of 5-FU and tegafur in the ascites fluid in patients with peritonitis carcinomatosa after UFT oral administration].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; Fluorouracil; G | 1987 |
[Report on nationwide pooled data and cohort investigation in UFT phase II study].
Topics: Anorexia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Sche | 1987 |
[Intraperitoneal (Ip) administration of cisplatin in combination with systemic chemotherapy in patients with malignant ascites of gastrointestinal cancer: clinical evaluation and pharmacokinetics].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; Cisplatin; D | 1988 |
[Evaluation of a combination of UFT, MMC, and OK-432 for advanced gastro-intestinal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Gastrointestinal Neop | 1987 |
Sensitivity test for 5-fluorouracil and its analogues, 1-(2-tetrahydrofuryl)-5-fluorouracil, uracil/1-(2-tetrahydrofuryl)-5-fluorouracil (4:1) and 1-hexylcarbamoyl-5-fluorouracil, using the subrenal capsule assay.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Fluorouracil; Gastrointest | 1988 |
[The possibility of treating malignant tumors of the gastrointestinal tract with 5-fluoracil].
Topics: Aged; Antimetabolites; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; | 1969 |