uracil and Anemia studies

Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

Research Excerpts

Excerpt	Relevance	Reference
"This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age."	7.91	Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer. ( Kimura, M; Teramachi, H; Usami, E; Yoshimura, T, 2019)
"Two phase III studies revealed an oral UFT/Leucovorin (LV) regimen, in which the drugs are taken for 28 consecutive days every 35 days, which proved to be equivalent to an infusional 5-fluorouracil/LV regimen for metastatic colorectal cancer (CRC)."	5.12	[Feasibility of weekday-on/weekend-off oral UFT/Leucovorin schedule as postoperative adjuvant chemotherapy for colorectal cancer]. ( Maeda, Y; Makuuchi, H; Murayama, C; Sadahiro, S; Suzuki, T, 2006)
" This phase II study assessed the response rate and toxicity profile of the combination of epirubicin, cisplatin and UFT in patients with metastatic adenocarcinoma of the stomach."	5.11	A phase II study of epirubicin, cisplatin and uracil-tegafur for advanced gastric carcinoma. ( Byun, JH; Choi, MG; Chung, IS; Hong, YS; Kang, JH; Kim, KW; Lee, KS; Lee, MA; Moon, DH; Park, SY; Shim, BY; Woo, IS, 2005)
"This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age."	3.91	Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer. ( Kimura, M; Teramachi, H; Usami, E; Yoshimura, T, 2019)
"Twenty-four patients with metastatic breast cancer that had progressed after high-dose chemotherapy with peripheral blood progenitor cell (PBPC) support were given intramuscular methotrexate in combination with oral UFT (tegafur and uracil) and oral leucovorin (the MUL regimen)."	3.69	Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. ( Ayala, F; Casado, A; Diaz-Rubio, E; López-Martin, JA; Martin, M; Nieto, Y; Rodriguez-Lescure, A, 1997)
"Increased extracellular concentrations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-induced inhibition of human granulocyte-macrophage progenitor cells without impairment of its antihuman immunodeficiency virus (HIV) activity."	3.68	Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. ( Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; St Clair, MH; Wiemann, MC, 1990)
" However, information about the rate of adverse events (AEs) across different DAA regimens is limited."	2.87	Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: a clinical randomized study. ( Andersen, ES; Bukh, J; Christensen, PB; Fahnøe, U; Gerstoft, J; Kjær, MS; Laursen, AL; Mössner, B; Pedersen, MS; Røge, BT; Schønning, K; Sølund, C; Weis, N, 2018)
" Major adverse events were neutropenia, leukopenia, anemia, and nausea."	2.82	Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors. ( Bando, H; Doi, T; Fuse, N; Goto, K; Ito, Y; Kojima, T; Mukai, H; Naito, Y; Ohtsu, A; Yamazaki, T; Yoshino, T, 2016)
"Gastric cancer is the most chemosensitive adenocarcinoma among digestive neoplasms."	2.68	The UFT/leucovorin/etoposide regimen for the treatment of advanced gastric cancer. Oncopaz Cooperative Group. ( Belón, J; de Castro, J; Espinosa, E; Feliu, J; García Alfonso, P; García Girón, C; Garrido, P; González Barón, M; Lomas, M; Ordóñez, A; Zamora, P, 1997)
"In the interferon era, the treatment of hepatitis C virus (HCV) infection in patients on haemodialysis (HD) was limited due to the significant number of treatment-related adverse events (AEs)."	1.51	Elimination of hepatitis C virus infection from a hemodialysis unit and impact of treatment on the control of anemia. ( Arias, M; Belmar, L; González, LN; Laguno, M; Llovet, LP; Londoño, MC; Maduell, F; Mallolas, J; Martínez-Rebollar, M; Ojeda, R; Rodas, L; Rossi, F; Ugalde, J, 2019)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (42.86)	18.7374
1990's	6 (21.43)	18.2507
2000's	4 (14.29)	29.6817
2010's	5 (17.86)	24.3611
2020's	1 (3.57)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Occult Hepatitis C Virus Infection In Hemodialysis Patients Who Achieved A Sustained Virological Response To Directly Acting Antiviral Drugs: Is It A Concern ?[NCT04719338]				30 participants (Actual)	Interventional	2021-03-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: a clinical randomized study. European journal of gastroenterology & hepatology, 2018, Volume: 30, Issue:10 Topics: 2-Naphthylamine; Adult; Anemia; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropane	2018
Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors. Cancer science, 2016, Volume: 107, Issue:5 Topics: Aged; Anemia; Antineoplastic Agents; Area Under Curve; Asian People; Biological Availability; Cross-	2016
A phase II study of epirubicin, cisplatin and uracil-tegafur for advanced gastric carcinoma. Japanese journal of clinical oncology, 2005, Volume: 35, Issue:1 Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Prot	2005
[Feasibility of weekday-on/weekend-off oral UFT/Leucovorin schedule as postoperative adjuvant chemotherapy for colorectal cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anemia; Anorexia; Antineoplastic Combined Chem	2006
Neoadjuvant therapy with cisplatin/fluorouracil vs cisplatin/UFT in locally advanced squamous cell head and neck cancer. Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10 Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous C	1997
UFT plus cisplatin in advanced non-small-cell lung cancer: interim analysis of 67 patients. Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10 Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cispla	1997
The UFT/leucovorin/etoposide regimen for the treatment of advanced gastric cancer. Oncopaz Cooperative Group. Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10 Topics: Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Combinations; Etop	1997
A phase II study of combined oral uracil and ftorafur with leucovorin for patients with squamous cell carcinoma of the head and neck. Cancer, 2001, Jul-15, Volume: 92, Issue:2 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anemia; Antimetabolites, Antineoplastic; Antin	2001

Article	Year
Hepatitis C therapy with direct antiviral agents in patients with advanced chronic kidney disease: real-world experience of the German Hepatitis C-Registry (Deutsches Hepatitis C-Register). European journal of gastroenterology & hepatology, 2019, Volume: 31, Issue:11 Topics: 2-Naphthylamine; Acute Disease; Adult; Aged; Anemia; Anilides; Antiviral Agents; Benzimidazoles; Car	2019
UHPLC Q-Exactive MS-based spleen metabolomics and lipidomics to explore the effect mechanisms of Danggui Buxue Decoction in anemia mice. Journal of pharmaceutical and biomedical analysis, 2020, Jun-05, Volume: 185 Topics: Anemia; Animals; Biomarkers; Chromatography, High Pressure Liquid; Cytosine; Disease Models, Animal;	2020
Elimination of hepatitis C virus infection from a hemodialysis unit and impact of treatment on the control of anemia. Gastroenterologia y hepatologia, 2019, Volume: 42, Issue:3 Topics: 2-Naphthylamine; Anemia; Anilides; Antiviral Agents; Carbamates; Cyclopropanes; Darbepoetin alfa; Fe	2019
Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer. Anticancer research, 2019, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Co	2019
Relative clinical and hematologic effects of concentrated liver extract, synthetic folic acid and synthetic 5-methyl uracil in the treatment of macrocytic anemias in relapse. The American journal of the medical sciences, 1947, Volume: 213, Issue:2 Topics: Anemia; Anemia, Macrocytic; Folic Acid; Liver; Liver Extracts; Recurrence; Uracil; Vitamin B Complex	1947
Further observations on the anti-anemic properties of 5-methyl uracil. The Journal of laboratory and clinical medicine, 1946, Volume: 31 Topics: Anemia; Uracil; Vitamin B Complex; Vitamins	1946
[Effect of uracil and methionine administered separately and simultaneously in experimental macrocytic anemia in rat]. Rendiconti - Istituto superiore di sanita, 1953, Volume: 16, Issue:4-6 Topics: Anemia; Anemia, Macrocytic; Animals; Methionine; Rats; Tracheophyta; Uracil	1953
[In vitro effect of vitamin B 12, folic acid and uracil on bone marrow in two cases of megaloblastic anemia; preliminary note]. Jornal do medico, 1953, Sep-05, Volume: 22, Issue:554 Topics: Anemia; Anemia, Megaloblastic; Bone Marrow; Folic Acid; Humans; In Vitro Techniques; Uracil; Vitamin	1953
[In vitro effect of vitamin B12, folic acid and uracil on bone marrow in two cases of megaloblastic anemia]. Gazeta medica portuguesa, 1953, Volume: 6, Issue:3 Topics: Anemia; Anemia, Megaloblastic; Bone Marrow; Folic Acid; Humans; In Vitro Techniques; Uracil; Vitamin	1953
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis]. La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40 Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin	1956
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis]. La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40 Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin	1956
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis]. La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40 Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin	1956
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis]. La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40 Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin	1956
URACIL MUSTARY THERAPY IN METASTATIC WILMS'S TUMOR. American journal of diseases of children (1960), 1964, Volume: 108 Topics: Anemia; Child; Drug Therapy; Leukopenia; Nausea; Neoplasm Metastasis; Nitrogen Mustard Compounds; Th	1964
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice. Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:2 Topics: Alkaloids; Anemia; Anemia, Hypochromic; Animals; Bacterial Toxins; Cholesterol; Cyanobacteria; Cyano	2004
Studies on the relationships of vitamin B12, folic acid, thymine, uracil and methyl group donors in persons with pernicious anemia and related megaloblastic anemias. Blood, 1950, Volume: 5, Issue:8 Topics: Anemia; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Hematinics; Thymine; Tissue Donors; U	1950
Near Infrared Absorption Spectra of Uracil, 5-Chlorouracil, and Thymine. Science (New York, N.Y.), 1949, Sep-23, Volume: 110, Issue:2856 Topics: Anemia; Humans; Thiourea; Thymine; Uracil	1949
Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10 Topics: Adult; Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diarrhea	1997
Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. Blood, 1990, Dec-01, Volume: 76, Issue:11 Topics: Anemia; Animals; Cell Line; Cytopathogenic Effect, Viral; Female; HIV; Leukopenia; Mice; Mice, Inbre	1990
Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice. Blood, 1990, Dec-01, Volume: 76, Issue:11 Topics: Acquired Immunodeficiency Syndrome; Anemia; Animals; Dose-Response Relationship, Drug; Female; Kinet	1990
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil. Acta medicinae Okayama, 1968, Volume: 22, Issue:6 Topics: Aminopterin; Anemia; Animals; Bromine; Cell Nucleus; DNA; Erythrocytes; Phenylhydrazines; Rats; RNA;	1968
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization. Acta medicinae Okayama, 1969, Volume: 23, Issue:1 Topics: Aminopterin; Anemia; Animals; Bone Marrow Cells; Cell Nucleolus; Culture Techniques; Cytoplasm; Eryt	1969
Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes. Journal of molecular biology, 1966, Volume: 20, Issue:1 Topics: Adenine; Anemia; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Ion Exchange; Cytosine; Dac	1966

uracil and Anemia

Research Excerpts

Research

Studies (28)

Authors

Clinical Trials (1)

Trial Overview

Trials

Other Studies

Authors	Studies
Wiegand, J	1
Buggisch, P	1
Mauss, S	1
Boeker, KHW	1
Klinker, H	1
Müller, T	1
Günther, R	1
Serfert, Y	1
Manns, MP	1
Zeuzem, S	1
Berg, T	1
Hinrichsen, H	1
C-Registry, GH	1
Liu, Y	1
Li, X	1
Li, A	1
Li, K	1
Qin, X	1
Sølund, C	1
Andersen, ES	1
Mössner, B	1
Laursen, AL	1
Røge, BT	1
Kjær, MS	1
Gerstoft, J	1
Christensen, PB	1
Pedersen, MS	1
Schønning, K	1
Fahnøe, U	1
Bukh, J	1
Weis, N	1
Maduell, F	1
Belmar, L	1
Ugalde, J	1
Laguno, M	1
Martínez-Rebollar, M	1
Ojeda, R	1
Arias, M	1
Rodas, L	1
Rossi, F	1
Llovet, LP	1
González, LN	1
Mallolas, J	1
Londoño, MC	1
Kimura, M	1
Usami, E	1
Teramachi, H	1
Yoshimura, T	1
Yoshino, T	1
Kojima, T	1
Bando, H	1
Yamazaki, T	1
Naito, Y	1
Mukai, H	1
Fuse, N	1
Goto, K	1
Ito, Y	1
Doi, T	1
Ohtsu, A	1
FROMMEYER, WB	2
SPIES, TD	2
TENTORI, L	1
VIVALDI, G	1
PARREIRA, F	2
CARONIA, F	2
PAGLIARO, L	2
PICCARDO, MG	2
VIETTI, TJ	1
BERRY, DH	1
FERNBACH, DJ	1
LUSHER, J	1
SUTOW, WW	1
Reisner, M	1
Carmeli, S	1
Werman, M	1
Sukenik, A	1
VILTER, RW	1
HORRIGAN, D	1
MUELLER, JF	1
JARROLD, T	1
VILTER, CF	1
HAWKINS, V	1
SEAMAN, A	1
Woo, IS	1
Moon, DH	1
Shim, BY	1
Lee, MA	1
Byun, JH	1
Kim, KW	1
Kang, JH	1
Choi, MG	1
Chung, IS	1
Hong, YS	1
Park, SY	1
Lee, KS	1
Sadahiro, S	1
Suzuki, T	1
Maeda, Y	1
Makuuchi, H	1
Murayama, C	1
Lacher, JR	1
Campion, DE	1
Park, JD	1
Martin, M	1
Casado, A	1
López-Martin, JA	1
Rodriguez-Lescure, A	1
Nieto, Y	1
Ayala, F	1
Diaz-Rubio, E	2
González-Larriba, JL	1
Garcia Carbonero, I	1
Sastre Valera, J	1
Perez Segura, P	1
Ichinose, Y	1
Yano, T	1
Kudoh, S	1
Yoshimori, K	1
Morikawa, T	1
Kuba, M	1
Niitani, H	1
González Barón, M	1
Espinosa, E	1
Feliu, J	1
Ordóñez, A	1
Zamora, P	1
de Castro, J	1
García Girón, C	1
García Alfonso, P	1
Garrido, P	1
Belón, J	1
Lomas, M	1
Colevas, AD	1
Amrein, PC	1
Gomolin, H	1
Barton, JJ	1
Read, RR	1
Adak, S	1
Benner, S	1
Costello, R	1
Posner, MR	1
Calabresi, P	2
Falcone, A	2
St Clair, MH	1
Wiemann, MC	1
Chu, SH	2
Darnowski, JW	2
Ruprecht, RM	1
Brunetti, I	1
Shigehisa, M	2
Attardi, G	1
Parnas, H	1
Hwang, MI	1
Attardi, B	1