Page last updated: 2024-10-20

uracil and Anemia

uracil has been researched along with Anemia in 28 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

Research Excerpts

ExcerptRelevanceReference
"This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age."7.91Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer. ( Kimura, M; Teramachi, H; Usami, E; Yoshimura, T, 2019)
"Two phase III studies revealed an oral UFT/Leucovorin (LV) regimen, in which the drugs are taken for 28 consecutive days every 35 days, which proved to be equivalent to an infusional 5-fluorouracil/LV regimen for metastatic colorectal cancer (CRC)."5.12[Feasibility of weekday-on/weekend-off oral UFT/Leucovorin schedule as postoperative adjuvant chemotherapy for colorectal cancer]. ( Maeda, Y; Makuuchi, H; Murayama, C; Sadahiro, S; Suzuki, T, 2006)
" This phase II study assessed the response rate and toxicity profile of the combination of epirubicin, cisplatin and UFT in patients with metastatic adenocarcinoma of the stomach."5.11A phase II study of epirubicin, cisplatin and uracil-tegafur for advanced gastric carcinoma. ( Byun, JH; Choi, MG; Chung, IS; Hong, YS; Kang, JH; Kim, KW; Lee, KS; Lee, MA; Moon, DH; Park, SY; Shim, BY; Woo, IS, 2005)
"This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age."3.91Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer. ( Kimura, M; Teramachi, H; Usami, E; Yoshimura, T, 2019)
"Twenty-four patients with metastatic breast cancer that had progressed after high-dose chemotherapy with peripheral blood progenitor cell (PBPC) support were given intramuscular methotrexate in combination with oral UFT (tegafur and uracil) and oral leucovorin (the MUL regimen)."3.69Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. ( Ayala, F; Casado, A; Diaz-Rubio, E; López-Martin, JA; Martin, M; Nieto, Y; Rodriguez-Lescure, A, 1997)
"Increased extracellular concentrations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-induced inhibition of human granulocyte-macrophage progenitor cells without impairment of its antihuman immunodeficiency virus (HIV) activity."3.68Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. ( Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; St Clair, MH; Wiemann, MC, 1990)
" However, information about the rate of adverse events (AEs) across different DAA regimens is limited."2.87Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: a clinical randomized study. ( Andersen, ES; Bukh, J; Christensen, PB; Fahnøe, U; Gerstoft, J; Kjær, MS; Laursen, AL; Mössner, B; Pedersen, MS; Røge, BT; Schønning, K; Sølund, C; Weis, N, 2018)
" Major adverse events were neutropenia, leukopenia, anemia, and nausea."2.82Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors. ( Bando, H; Doi, T; Fuse, N; Goto, K; Ito, Y; Kojima, T; Mukai, H; Naito, Y; Ohtsu, A; Yamazaki, T; Yoshino, T, 2016)
"Gastric cancer is the most chemosensitive adenocarcinoma among digestive neoplasms."2.68The UFT/leucovorin/etoposide regimen for the treatment of advanced gastric cancer. Oncopaz Cooperative Group. ( Belón, J; de Castro, J; Espinosa, E; Feliu, J; García Alfonso, P; García Girón, C; Garrido, P; González Barón, M; Lomas, M; Ordóñez, A; Zamora, P, 1997)
"In the interferon era, the treatment of hepatitis C virus (HCV) infection in patients on haemodialysis (HD) was limited due to the significant number of treatment-related adverse events (AEs)."1.51Elimination of hepatitis C virus infection from a hemodialysis unit and impact of treatment on the control of anemia. ( Arias, M; Belmar, L; González, LN; Laguno, M; Llovet, LP; Londoño, MC; Maduell, F; Mallolas, J; Martínez-Rebollar, M; Ojeda, R; Rodas, L; Rossi, F; Ugalde, J, 2019)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199012 (42.86)18.7374
1990's6 (21.43)18.2507
2000's4 (14.29)29.6817
2010's5 (17.86)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Wiegand, J1
Buggisch, P1
Mauss, S1
Boeker, KHW1
Klinker, H1
Müller, T1
Günther, R1
Serfert, Y1
Manns, MP1
Zeuzem, S1
Berg, T1
Hinrichsen, H1
C-Registry, GH1
Liu, Y1
Li, X1
Li, A1
Li, K1
Qin, X1
Sølund, C1
Andersen, ES1
Mössner, B1
Laursen, AL1
Røge, BT1
Kjær, MS1
Gerstoft, J1
Christensen, PB1
Pedersen, MS1
Schønning, K1
Fahnøe, U1
Bukh, J1
Weis, N1
Maduell, F1
Belmar, L1
Ugalde, J1
Laguno, M1
Martínez-Rebollar, M1
Ojeda, R1
Arias, M1
Rodas, L1
Rossi, F1
Llovet, LP1
González, LN1
Mallolas, J1
Londoño, MC1
Kimura, M1
Usami, E1
Teramachi, H1
Yoshimura, T1
Yoshino, T1
Kojima, T1
Bando, H1
Yamazaki, T1
Naito, Y1
Mukai, H1
Fuse, N1
Goto, K1
Ito, Y1
Doi, T1
Ohtsu, A1
FROMMEYER, WB2
SPIES, TD2
TENTORI, L1
VIVALDI, G1
PARREIRA, F2
CARONIA, F2
PAGLIARO, L2
PICCARDO, MG2
VIETTI, TJ1
BERRY, DH1
FERNBACH, DJ1
LUSHER, J1
SUTOW, WW1
Reisner, M1
Carmeli, S1
Werman, M1
Sukenik, A1
VILTER, RW1
HORRIGAN, D1
MUELLER, JF1
JARROLD, T1
VILTER, CF1
HAWKINS, V1
SEAMAN, A1
Woo, IS1
Moon, DH1
Shim, BY1
Lee, MA1
Byun, JH1
Kim, KW1
Kang, JH1
Choi, MG1
Chung, IS1
Hong, YS1
Park, SY1
Lee, KS1
Sadahiro, S1
Suzuki, T1
Maeda, Y1
Makuuchi, H1
Murayama, C1
Lacher, JR1
Campion, DE1
Park, JD1
Martin, M1
Casado, A1
López-Martin, JA1
Rodriguez-Lescure, A1
Nieto, Y1
Ayala, F1
Diaz-Rubio, E2
González-Larriba, JL1
Garcia Carbonero, I1
Sastre Valera, J1
Perez Segura, P1
Ichinose, Y1
Yano, T1
Kudoh, S1
Yoshimori, K1
Morikawa, T1
Kuba, M1
Niitani, H1
González Barón, M1
Espinosa, E1
Feliu, J1
Ordóñez, A1
Zamora, P1
de Castro, J1
García Girón, C1
García Alfonso, P1
Garrido, P1
Belón, J1
Lomas, M1
Colevas, AD1
Amrein, PC1
Gomolin, H1
Barton, JJ1
Read, RR1
Adak, S1
Benner, S1
Costello, R1
Posner, MR1
Calabresi, P2
Falcone, A2
St Clair, MH1
Wiemann, MC1
Chu, SH2
Darnowski, JW2
Ruprecht, RM1
Brunetti, I1
Shigehisa, M2
Attardi, G1
Parnas, H1
Hwang, MI1
Attardi, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Occult Hepatitis C Virus Infection In Hemodialysis Patients Who Achieved A Sustained Virological Response To Directly Acting Antiviral Drugs: Is It A Concern ?[NCT04719338]30 participants (Actual)Interventional2021-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

8 trials available for uracil and Anemia

ArticleYear
Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: a clinical randomized study.
    European journal of gastroenterology & hepatology, 2018, Volume: 30, Issue:10

    Topics: 2-Naphthylamine; Adult; Anemia; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropane

2018
Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors.
    Cancer science, 2016, Volume: 107, Issue:5

    Topics: Aged; Anemia; Antineoplastic Agents; Area Under Curve; Asian People; Biological Availability; Cross-

2016
A phase II study of epirubicin, cisplatin and uracil-tegafur for advanced gastric carcinoma.
    Japanese journal of clinical oncology, 2005, Volume: 35, Issue:1

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Prot

2005
[Feasibility of weekday-on/weekend-off oral UFT/Leucovorin schedule as postoperative adjuvant chemotherapy for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anemia; Anorexia; Antineoplastic Combined Chem

2006
Neoadjuvant therapy with cisplatin/fluorouracil vs cisplatin/UFT in locally advanced squamous cell head and neck cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous C

1997
UFT plus cisplatin in advanced non-small-cell lung cancer: interim analysis of 67 patients.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cispla

1997
The UFT/leucovorin/etoposide regimen for the treatment of advanced gastric cancer. Oncopaz Cooperative Group.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Combinations; Etop

1997
A phase II study of combined oral uracil and ftorafur with leucovorin for patients with squamous cell carcinoma of the head and neck.
    Cancer, 2001, Jul-15, Volume: 92, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anemia; Antimetabolites, Antineoplastic; Antin

2001

Other Studies

20 other studies available for uracil and Anemia

ArticleYear
Hepatitis C therapy with direct antiviral agents in patients with advanced chronic kidney disease: real-world experience of the German Hepatitis C-Registry (Deutsches Hepatitis C-Register).
    European journal of gastroenterology & hepatology, 2019, Volume: 31, Issue:11

    Topics: 2-Naphthylamine; Acute Disease; Adult; Aged; Anemia; Anilides; Antiviral Agents; Benzimidazoles; Car

2019
UHPLC Q-Exactive MS-based spleen metabolomics and lipidomics to explore the effect mechanisms of Danggui Buxue Decoction in anemia mice.
    Journal of pharmaceutical and biomedical analysis, 2020, Jun-05, Volume: 185

    Topics: Anemia; Animals; Biomarkers; Chromatography, High Pressure Liquid; Cytosine; Disease Models, Animal;

2020
Elimination of hepatitis C virus infection from a hemodialysis unit and impact of treatment on the control of anemia.
    Gastroenterologia y hepatologia, 2019, Volume: 42, Issue:3

    Topics: 2-Naphthylamine; Anemia; Anilides; Antiviral Agents; Carbamates; Cyclopropanes; Darbepoetin alfa; Fe

2019
Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer.
    Anticancer research, 2019, Volume: 39, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Co

2019
Relative clinical and hematologic effects of concentrated liver extract, synthetic folic acid and synthetic 5-methyl uracil in the treatment of macrocytic anemias in relapse.
    The American journal of the medical sciences, 1947, Volume: 213, Issue:2

    Topics: Anemia; Anemia, Macrocytic; Folic Acid; Liver; Liver Extracts; Recurrence; Uracil; Vitamin B Complex

1947
Further observations on the anti-anemic properties of 5-methyl uracil.
    The Journal of laboratory and clinical medicine, 1946, Volume: 31

    Topics: Anemia; Uracil; Vitamin B Complex; Vitamins

1946
[Effect of uracil and methionine administered separately and simultaneously in experimental macrocytic anemia in rat].
    Rendiconti - Istituto superiore di sanita, 1953, Volume: 16, Issue:4-6

    Topics: Anemia; Anemia, Macrocytic; Animals; Methionine; Rats; Tracheophyta; Uracil

1953
[In vitro effect of vitamin B 12, folic acid and uracil on bone marrow in two cases of megaloblastic anemia; preliminary note].
    Jornal do medico, 1953, Sep-05, Volume: 22, Issue:554

    Topics: Anemia; Anemia, Megaloblastic; Bone Marrow; Folic Acid; Humans; In Vitro Techniques; Uracil; Vitamin

1953
[In vitro effect of vitamin B12, folic acid and uracil on bone marrow in two cases of megaloblastic anemia].
    Gazeta medica portuguesa, 1953, Volume: 6, Issue:3

    Topics: Anemia; Anemia, Megaloblastic; Bone Marrow; Folic Acid; Humans; In Vitro Techniques; Uracil; Vitamin

1953
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis].
    La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40

    Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin

1956
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis].
    La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40

    Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin

1956
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis].
    La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40

    Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin

1956
[Correlation of biochemical data, clinical aspects and therapeutic reaction in megaloblastosis].
    La Riforma medica, 1956, Oct-06, Volume: 70, Issue:40

    Topics: Anemia; beta-Thalassemia; Corrinoids; Erythroblasts; Folic Acid; Hematinics; Humans; Uracil; Vitamin

1956
URACIL MUSTARY THERAPY IN METASTATIC WILMS'S TUMOR.
    American journal of diseases of children (1960), 1964, Volume: 108

    Topics: Anemia; Child; Drug Therapy; Leukopenia; Nausea; Neoplasm Metastasis; Nitrogen Mustard Compounds; Th

1964
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:2

    Topics: Alkaloids; Anemia; Anemia, Hypochromic; Animals; Bacterial Toxins; Cholesterol; Cyanobacteria; Cyano

2004
Studies on the relationships of vitamin B12, folic acid, thymine, uracil and methyl group donors in persons with pernicious anemia and related megaloblastic anemias.
    Blood, 1950, Volume: 5, Issue:8

    Topics: Anemia; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Hematinics; Thymine; Tissue Donors; U

1950
Near Infrared Absorption Spectra of Uracil, 5-Chlorouracil, and Thymine.
    Science (New York, N.Y.), 1949, Sep-23, Volume: 110, Issue:2856

    Topics: Anemia; Humans; Thiourea; Thymine; Uracil

1949
Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diarrhea

1997
Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.
    Blood, 1990, Dec-01, Volume: 76, Issue:11

    Topics: Anemia; Animals; Cell Line; Cytopathogenic Effect, Viral; Female; HIV; Leukopenia; Mice; Mice, Inbre

1990
Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice.
    Blood, 1990, Dec-01, Volume: 76, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Anemia; Animals; Dose-Response Relationship, Drug; Female; Kinet

1990
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil.
    Acta medicinae Okayama, 1968, Volume: 22, Issue:6

    Topics: Aminopterin; Anemia; Animals; Bromine; Cell Nucleus; DNA; Erythrocytes; Phenylhydrazines; Rats; RNA;

1968
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization.
    Acta medicinae Okayama, 1969, Volume: 23, Issue:1

    Topics: Aminopterin; Anemia; Animals; Bone Marrow Cells; Cell Nucleolus; Culture Techniques; Cytoplasm; Eryt

1969
Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes.
    Journal of molecular biology, 1966, Volume: 20, Issue:1

    Topics: Adenine; Anemia; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Ion Exchange; Cytosine; Dac

1966