uracil and Aging
uracil has been researched along with Aging in 19 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Disturbed deoxythymidine triphosphate biosynthesis due to the inhibition of thymidylate synthase (TS) can lead to uracil accumulation in DNA, eventually, lead to neurocytes apoptosis and cognitive decline." | 8.02 | Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism. ( Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D, 2021) |
| "Disturbed deoxythymidine triphosphate biosynthesis due to the inhibition of thymidylate synthase (TS) can lead to uracil accumulation in DNA, eventually, lead to neurocytes apoptosis and cognitive decline." | 4.02 | Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism. ( Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D, 2021) |
| "Oxoguanine DNA glycosylase (OGG1) and uracil DNA glycosylase (UDG) are two of the most important repair enzymes that are involved in the base excision repair processes to eliminate oxidative damage from mammalian DNA, which accumulates with aging." | 3.74 | 8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats. ( Goto, S; Kumagai, S; Nakamoto, H; Radak, Z, 2007) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (42.11) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zhou, D | 1 |
| Lv, X | 1 |
| Wang, Y | 1 |
| Liu, H | 1 |
| Luo, S | 1 |
| Li, W | 1 |
| Huang, G | 1 |
| Saba, CF | 1 |
| Schmiedt, CW | 1 |
| Freeman, KG | 1 |
| Edwards, GL | 1 |
| Fenech, M | 1 |
| Bourdel-Marchasson, I | 1 |
| Schweizer, A | 1 |
| Dejager, S | 1 |
| Swain, U | 1 |
| Rao, KS | 1 |
| Ishchenko, A | 1 |
| Sinitsyna, O | 1 |
| Krysanova, Z | 1 |
| Vasyunina, EA | 1 |
| Saparbaev, M | 1 |
| Sidorkina, O | 1 |
| Nevinsky, GA | 1 |
| Radak, Z | 1 |
| Kumagai, S | 1 |
| Nakamoto, H | 1 |
| Goto, S | 1 |
| Laudenbach, V | 1 |
| Fontaine, RH | 1 |
| Medja, F | 1 |
| Carmeliet, P | 1 |
| Hicklin, DJ | 1 |
| Gallego, J | 1 |
| Leroux, P | 1 |
| Marret, S | 1 |
| Gressens, P | 1 |
| Wang, YJ | 1 |
| Ho, YS | 1 |
| Lo, MJ | 1 |
| Lin, JK | 1 |
| Bregliano, JC | 1 |
| Laurençon, A | 1 |
| Degroote, F | 1 |
| Croteau, DL | 1 |
| Stierum, RH | 1 |
| Bohr, VA | 1 |
| Engelbrecht, C | 1 |
| Yngner, T | 1 |
| Assmann, B | 1 |
| Haas, HJ | 1 |
| Totibadze, NV | 1 |
| Suleĭmanova, NS | 1 |
| Van'ko, LV | 1 |
| Fisenko, AP | 1 |
| Sukhikh, GT | 1 |
| Krasnova, AF | 1 |
| Jakubovic, A | 1 |
| McGeer, PL | 1 |
| Valotaire, Y | 1 |
| Duval, J | 1 |
| Yajima, A | 1 |
| Ringborg, U | 1 |
Reviews
3 reviews available for uracil and Aging
| Article | Year |
|---|---|
Folate, DNA damage and the aging brain.
Topics: Aging; Animals; Brain; Cell Nucleus; Cytosine; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; M | 2010 |
Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.
Topics: Adamantane; Age Factors; Aged; Aging; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptide | 2011 |
Mitochondrial DNA repair pathways.
Topics: Aging; Alkylation; Animals; Cell Nucleus; DNA Repair; DNA, Mitochondrial; Models, Biological; Mutati | 1999 |
Other Studies
16 other studies available for uracil and Aging
| Article | Year |
|---|---|
Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism.
Topics: Aging; Animals; Apoptosis; Brain; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Male; Memo | 2021 |
Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.
Topics: Aging; Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dihydrouracil Dehydrogenase (NA | 2013 |
Age-dependent decline of DNA base excision repair activity in rat cortical neurons.
Topics: Age Factors; Aging; Animals; Cerebral Cortex; DNA Damage; DNA Ligases; DNA Polymerase beta; DNA Repa | 2012 |
Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil- DNA glycosylase activities in liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats.
Topics: Aging; Animals; Cell Nucleus; DNA Glycosylases; DNA-Formamidopyrimidine Glycosylase; Electrophoresis | 2003 |
8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats.
Topics: Age Factors; Aging; Animals; Cell Nucleus; DNA Repair; DNA, Mitochondrial; Guanosine; Male; Muscle F | 2007 |
Neonatal hypoxic preconditioning involves vascular endothelial growth factor.
Topics: Aging; Alanine; Animals; Animals, Newborn; Antibodies, Blocking; Brain; Excitatory Amino Acid Agonis | 2007 |
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA D | 1995 |
Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. I. Induction by inhibitors of nucleotide synthesis and by gamma rays.
Topics: Aging; Animals; Antimetabolites; Cesium Radioisotopes; DNA Repair; Dose-Response Relationship, Drug; | 1995 |
Metabolism of uridine and determination of liver ribonucleic acid synthesis in developing and adult mice.
Topics: Aging; Alanine; Animals; beta-Alanine; Liver; Male; Mice; Orotic Acid; RNA; Tritium; Uracil; Uridine | 1985 |
Determination of the age dependency of the creatinine-related pseudouridine excretion in children's urine by high-performance liquid chromatography.
Topics: Adolescent; Aging; Child; Child, Preschool; Chromatography, High Pressure Liquid; Creatinine; Female | 1988 |
[Effect of diucifon on the natural cytotoxic activity of splenic cells in old rats].
Topics: Adjuvants, Immunologic; Aging; Animals; Concanavalin A; Cytotoxicity, Immunologic; Drug Combinations | 1988 |
[Age characteristics of the dynamics of nucleic acid and protein metabolism during muscular activity and relaxation].
Topics: Aged; Aging; Animals; Blood Proteins; DNA; Humans; Liver; Middle Aged; Muscle Proteins; Muscles; Phy | 1972 |
Inhibition of rat brain protein and nucleic acid synthesis by cannabinoids in vitro.
Topics: Aging; Animals; Animals, Newborn; Cannabis; Carbon Dioxide; Carbon Isotopes; Cerebral Cortex; Depres | 1972 |
[Modification of nucleic acid metabolism in rat pituitary during sexual maturation and by castration].
Topics: Aging; Animals; Castration; DNA; Gonads; Male; Pituitary Gland; Proteins; Rats; RNA; Thymidine; Urac | 1970 |
The decrepitude of the rat brain with special reference to changes in nucleic acid.
Topics: Adenine; Aging; Animals; Brain Chemistry; Brain Stem; Cerebellum; Chromatography; Cytosine; Dienceph | 1966 |
Composition and content of RNA in neurons of rat hippocampus at different ages.
Topics: Adenine; Aging; Animals; Animals, Newborn; Chemical Phenomena; Chemistry; Cytosine; Electrophoresis; | 1966 |