Page last updated: 2024-10-20

uracil and Aging

uracil has been researched along with Aging in 19 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Disturbed deoxythymidine triphosphate biosynthesis due to the inhibition of thymidylate synthase (TS) can lead to uracil accumulation in DNA, eventually, lead to neurocytes apoptosis and cognitive decline."8.02Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism. ( Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D, 2021)
"Disturbed deoxythymidine triphosphate biosynthesis due to the inhibition of thymidylate synthase (TS) can lead to uracil accumulation in DNA, eventually, lead to neurocytes apoptosis and cognitive decline."4.02Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism. ( Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D, 2021)
"Oxoguanine DNA glycosylase (OGG1) and uracil DNA glycosylase (UDG) are two of the most important repair enzymes that are involved in the base excision repair processes to eliminate oxidative damage from mammalian DNA, which accumulates with aging."3.748-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats. ( Goto, S; Kumagai, S; Nakamoto, H; Radak, Z, 2007)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19908 (42.11)18.7374
1990's3 (15.79)18.2507
2000's3 (15.79)29.6817
2010's4 (21.05)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Zhou, D1
Lv, X1
Wang, Y1
Liu, H1
Luo, S1
Li, W1
Huang, G1
Saba, CF1
Schmiedt, CW1
Freeman, KG1
Edwards, GL1
Fenech, M1
Bourdel-Marchasson, I1
Schweizer, A1
Dejager, S1
Swain, U1
Rao, KS1
Ishchenko, A1
Sinitsyna, O1
Krysanova, Z1
Vasyunina, EA1
Saparbaev, M1
Sidorkina, O1
Nevinsky, GA1
Radak, Z1
Kumagai, S1
Nakamoto, H1
Goto, S1
Laudenbach, V1
Fontaine, RH1
Medja, F1
Carmeliet, P1
Hicklin, DJ1
Gallego, J1
Leroux, P1
Marret, S1
Gressens, P1
Wang, YJ1
Ho, YS1
Lo, MJ1
Lin, JK1
Bregliano, JC1
Laurençon, A1
Degroote, F1
Croteau, DL1
Stierum, RH1
Bohr, VA1
Engelbrecht, C1
Yngner, T1
Assmann, B1
Haas, HJ1
Totibadze, NV1
Suleĭmanova, NS1
Van'ko, LV1
Fisenko, AP1
Sukhikh, GT1
Krasnova, AF1
Jakubovic, A1
McGeer, PL1
Valotaire, Y1
Duval, J1
Yajima, A1
Ringborg, U1

Reviews

3 reviews available for uracil and Aging

ArticleYear
Folate, DNA damage and the aging brain.
    Mechanisms of ageing and development, 2010, Volume: 131, Issue:4

    Topics: Aging; Animals; Brain; Cell Nucleus; Cytosine; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; M

2010
Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.
    Hospital practice (1995), 2011, Volume: 39, Issue:1

    Topics: Adamantane; Age Factors; Aged; Aging; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptide

2011
Mitochondrial DNA repair pathways.
    Mutation research, 1999, Jul-30, Volume: 434, Issue:3

    Topics: Aging; Alkylation; Animals; Cell Nucleus; DNA Repair; DNA, Mitochondrial; Models, Biological; Mutati

1999

Other Studies

16 other studies available for uracil and Aging

ArticleYear
Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism.
    The Journal of nutritional biochemistry, 2021, Volume: 97

    Topics: Aging; Animals; Apoptosis; Brain; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Male; Memo

2021
Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.
    Veterinary and comparative oncology, 2013, Volume: 11, Issue:4

    Topics: Aging; Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dihydrouracil Dehydrogenase (NA

2013
Age-dependent decline of DNA base excision repair activity in rat cortical neurons.
    Mechanisms of ageing and development, 2012, Volume: 133, Issue:4

    Topics: Age Factors; Aging; Animals; Cerebral Cortex; DNA Damage; DNA Ligases; DNA Polymerase beta; DNA Repa

2012
Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil- DNA glycosylase activities in liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats.
    Medical science monitor : international medical journal of experimental and clinical research, 2003, Volume: 9, Issue:1

    Topics: Aging; Animals; Cell Nucleus; DNA Glycosylases; DNA-Formamidopyrimidine Glycosylase; Electrophoresis

2003
8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4

    Topics: Age Factors; Aging; Animals; Cell Nucleus; DNA Repair; DNA, Mitochondrial; Guanosine; Male; Muscle F

2007
Neonatal hypoxic preconditioning involves vascular endothelial growth factor.
    Neurobiology of disease, 2007, Volume: 26, Issue:1

    Topics: Aging; Alanine; Animals; Animals, Newborn; Antibodies, Blocking; Brain; Excitatory Amino Acid Agonis

2007
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
    Chemico-biological interactions, 1995, Volume: 94, Issue:2

    Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA D

1995
Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. I. Induction by inhibitors of nucleotide synthesis and by gamma rays.
    Genetics, 1995, Volume: 141, Issue:2

    Topics: Aging; Animals; Antimetabolites; Cesium Radioisotopes; DNA Repair; Dose-Response Relationship, Drug;

1995
Metabolism of uridine and determination of liver ribonucleic acid synthesis in developing and adult mice.
    The International journal of biochemistry, 1985, Volume: 17, Issue:4

    Topics: Aging; Alanine; Animals; beta-Alanine; Liver; Male; Mice; Orotic Acid; RNA; Tritium; Uracil; Uridine

1985
Determination of the age dependency of the creatinine-related pseudouridine excretion in children's urine by high-performance liquid chromatography.
    Journal of chromatography, 1988, Dec-29, Volume: 434, Issue:1

    Topics: Adolescent; Aging; Child; Child, Preschool; Chromatography, High Pressure Liquid; Creatinine; Female

1988
[Effect of diucifon on the natural cytotoxic activity of splenic cells in old rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:8

    Topics: Adjuvants, Immunologic; Aging; Animals; Concanavalin A; Cytotoxicity, Immunologic; Drug Combinations

1988
[Age characteristics of the dynamics of nucleic acid and protein metabolism during muscular activity and relaxation].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1972, Volume: 58, Issue:4

    Topics: Aged; Aging; Animals; Blood Proteins; DNA; Humans; Liver; Middle Aged; Muscle Proteins; Muscles; Phy

1972
Inhibition of rat brain protein and nucleic acid synthesis by cannabinoids in vitro.
    Canadian journal of biochemistry, 1972, Volume: 50, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Cannabis; Carbon Dioxide; Carbon Isotopes; Cerebral Cortex; Depres

1972
[Modification of nucleic acid metabolism in rat pituitary during sexual maturation and by castration].
    Biochimica et biophysica acta, 1970, Nov-12, Volume: 224, Issue:1

    Topics: Aging; Animals; Castration; DNA; Gonads; Male; Pituitary Gland; Proteins; Rats; RNA; Thymidine; Urac

1970
The decrepitude of the rat brain with special reference to changes in nucleic acid.
    The Tohoku journal of experimental medicine, 1966, Jul-25, Volume: 89, Issue:3

    Topics: Adenine; Aging; Animals; Brain Chemistry; Brain Stem; Cerebellum; Chromatography; Cytosine; Dienceph

1966
Composition and content of RNA in neurons of rat hippocampus at different ages.
    Brain research, 1966, Volume: 2, Issue:3

    Topics: Adenine; Aging; Animals; Animals, Newborn; Chemical Phenomena; Chemistry; Cytosine; Electrophoresis;

1966