unc2025 and Thrombosis

Essentials Signaling by Gas6 through Tyro3/Axl/Mer receptors is essential for stable platelet aggregation. UNC2025 is a small molecule inhibitor of the Mer tyrosine kinase. UNC2025 decreases platelet activation in vitro and thrombus formation in vivo. UNC2025's anti-platelet effect is synergistic with inhibition of the ADP receptor, P2Y. Background Growth arrest-specific protein 6 signals through the TAM (TYRO-3-AXL-MERTK) receptor family, mediating platelet activation and thrombus formation via activation of the aggregate-stabilizing α

Topics: Adenine; Animals; Axl Receptor Tyrosine Kinase; Blood Platelets; c-Mer Tyrosine Kinase; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Humans; Intercellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Phosphorylation; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pulmonary Embolism; Purinergic P2Y Receptor Antagonists; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thrombosis

Topics: Adenine; Blood Platelets; c-Mer Tyrosine Kinase; Humans; Piperazines; Platelet Activation; Thrombosis