ulixacaltamide and Epilepsy

ulixacaltamide has been researched along with Epilepsy* in 1 studies

Other Studies

1 other study(ies) available for ulixacaltamide and Epilepsy

Article	Year
Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers. Journal of medicinal chemistry, 2016, Sep-22, Volume: 59, Issue:18 A series of dihydropyrazole derivatives was developed as potent, selective, and brain-penetrating T-type calcium channel blockers. An optimized derivative, compound 6c, was advanced to in vivo studies, where it demonstrated efficacy in the WAG/Rij rat model of generalized nonconvulsive, absence-like epilepsy. Compound 6c was not efficacious in the basolateral amygdala kindling rat model of temporal lobe epilepsy, and it led to prolongation of the PR interval in ECG recordings in rodents. Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dogs; Electroencephalography; Epilepsy; Humans; Kindling, Neurologic; Male; Pyrazoles; Rats, Wistar	2016

Article

Year

Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.

Journal of medicinal chemistry, 2016, Sep-22, Volume: 59, Issue:18

A series of dihydropyrazole derivatives was developed as potent, selective, and brain-penetrating T-type calcium channel blockers. An optimized derivative, compound 6c, was advanced to in vivo studies, where it demonstrated efficacy in the WAG/Rij rat model of generalized nonconvulsive, absence-like epilepsy. Compound 6c was not efficacious in the basolateral amygdala kindling rat model of temporal lobe epilepsy, and it led to prolongation of the PR interval in ECG recordings in rodents.

Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dogs; Electroencephalography; Epilepsy; Humans; Kindling, Neurologic; Male; Pyrazoles; Rats, Wistar

2016