Page last updated: 2024-08-25

uk 68798 and Torsade de Pointes

uk 68798 has been researched along with Torsade de Pointes in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (7.79)	18.2507
2000's	39 (50.65)	29.6817
2010's	30 (38.96)	24.3611
2020's	2 (2.60)	2.80

Authors

Authors	Studies
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Baroudi, S; Basset, M; Benito, S; Dayan, F; Koloskoff, K; Llopis-Lorente, J; Mora, MT; Romero, L; Saiz, J; Trenor, B	1
Knowles, D; Malloy, R; Ting, C	1
Hondeghem, LM	1
Hamlin, RL; Kijtawornrat, A; Limprasutr, V; Meedech, P; Saengklub, N	1
Bhargava, M; Cho, JH; Chung, MK; Kyriakakis, R; Lindsay, BD; Militello, M; Moore, JC; Niebauer, MJ; Poe, SM; Saliba, WI; Tchou, PJ; Varma, N; Vekstein, C; Wazni, OM; Wilkoff, BL; Wolski, K; Youn, SJ	1
Beekman, HDM; Belardinelli, L; Bossu, A; de Bakker, JMT; Dunnink, A; Houtman, MJC; Meijborg, VMF; Mollova, N; Rajamani, S; van der Heyden, MAG; Varkevisser, R; Vos, MA	1
Al-Khatib, SM; Allen LaPointe, NM; Bahnson, TD; Campbell, KB; Daubert, JP; Jackson, KP; Picini, JP; Pokorney, SD; Sheng, S; Thomas, KL; Thomas, L; Yen, DC	1
Ackerman, MJ; Asirvatham, SJ; DeSimone, CV; Kapa, S; Kella, D; Lee, HC; Naksuk, N; Noseworthy, PA; Padmanabhan, D; Sugrue, AM	1
Kuhl, E; Sahli Costabal, F; Sher, A; Yao, J	1
Adelstein, E; Barrington, W; Bazaz, R; Brumberg, G; Gera, N; Jain, SK; Mendenhall, GS; Nemec, J; Pray, C; Saba, S; Schwartzman, D; Voigt, A; Wang, NC	1
Beekman, JD; Tieland, RG; van der Heyden, MA; Varkevisser, R; Vos, MA	2
Beekman, HD; Bourgonje, VJ; Oosterhoff, P; Schoenmakers, M; Stams, TR; van der Nagel, R; van Opstal, JM; Vos, MA	1
Csík, N; Farkas, A; Farkas, AS; Farkas, S; Forster, T; Orosz, S; Papp, JG; Sarusi, A; Varró, A	1
Chun, YW; Hong, C; Knollmann, BC; Mosley, JD; Roden, DM; Stroud, DM; Yang, T	1
Champeroux, P; Fowler, JS; Judé, S; Laigot-Barbé, C; Le Guennec, JY; Maurin, A; Richard, S; Sola, ML; Thireau, J	1
Ackerman, MJ; Asirvatham, SJ; Brady, P; DeSimone, CV; Friedman, P; Kremen, V; Noseworthy, PA; Qiang, B; Sapir, Y; Sheldon, SH; Striemer, BL; Sugrue, A	1
Beekman, JD; Dunnink, A; Heijdel, A; Oosterhoff, P; Stams, TR; van der Heyden, MA; van der Nagel, R; van Rijen, HV; Vos, MA	1
Hosseini, M; Johannesen, L; Mason, JW; Pueyo, E; Sager, PT; Strauss, DG; Vicente, J	1
Shah, Y; Steinberg, JS; Szepietowska, B	1
Dhein, S; Mohr, FW; Perlitz, F	1
David, M; Dujardin, KS; Dumotier, B; Guizy, M; Hondeghem, LM; Valenzuela, C	1
Backx, PH; Dorian, P; So, PP	1
Csanády, M; Csík, N; Farkas, A; Farkas, AS; Forster, T; Fülöp, F; Makra, P; Orosz, S; Papp, JG; Shattock, MJ; Varró, A	1
Antoons, G; Beekman, JD; Belardinelli, L; Engelen, MA; Houtman, MJ; Oros, A; Stengl, M; Vos, MA	1
Beekman, J; Dunnink, A; Montagne, D; Oosterhoff, P; Sharif, S; van der Heyden, MA; van der Nagel, R; Vos, MA; Winckels, S	1
Csanády, M; Csík, N; Farkas, A; Farkas, AS; Forster, T; Leprán, I; Makra, P; Papp, JG; Rudas, L; Varró, A	1
Antoons, G; Attevelt, NJ; Beekman, JD; Belardinelli, L; Gomez, AM; Houtman, MJ; Neco, P; Oosterhoff, P; Oros, A; Rajamani, S; Richard, S; van der Heyden, MA; Ver Donck, L; Vos, MA	1
Beekman, JD; de Boer, TP; Duker, G; Houtman, MJ; Jonsson, MK; Nalos, L; Peschar, M; Rook, MB; Sartipy, P; Thomsen, MB; van der Heyden, MA; van der Nagel, R; van Veen, TA; Varkevisser, R; Vos, MA	1
Beekman, JD; Cora Verduyn, S; Dunnink, A; Oosterhoff, P; van der Nagel, R; van Opstal, JM; Vos, MA; Winckels, SK	1
Beekman, JD; Chamberlin, P; der Nagel, Rv; Dittrich, HC; Oros, A; Stams, TR; Vos, MA	1
Hamlin, RL; Kijtawornrat, A; Sawangkoon, S	1
Abi-Gerges, N; Boyett, MR; Davies, MR; Di Veroli, GY; Zhang, H	1
Crijns, HJ; Vos, MA	1
Wolbrette, DL	1
Hashimoto, K; Miyata, K; Nakamura, Y; Sato, S; Satoh, Y; Shimizu-Sasamata, M; Sugiyama, A; Takahara, A	1
Leunissen, JD; Londoño, C; Ramakers, C; Schoenmakers, M; van Opstal, JM; Vos, MA	1
Allen LaPointe, NM; Califf, RM; Chen, A; DeLong, E; Hammill, B; Kramer, JM	1
Freeland, S; Worthy, C; Zolnierz, M	1
Brendorp, B; Elming, H; Køber, L; Pedersen, OD; Pehrson, S; Torp-Petersen, C	1
Cordes, JS; Lloyd, DB; Mank-Seymour, A; Milos, PM; Richmond, J; Sun, Z; Thompson, JF; Zhou, J	1
Alexander, P; Davie, C; Mitcheson, J; Pierre-Valentin, J; Pollard, C; Standen, N; Thong, B	1
Andreas, JO; Hauser, R; Jahnel, U; Linz, K; Schneider, J	1
Carlsson, L; Kowey, PR; Liu, T; Wu, Y; Yan, GX	1
Reiffel, JA	1
Kantharia, BK; Ledley, GS; Nagra, BS	1
Beatch, GN; Ezrin, AM; Fedida, D; Hesketh, JC; Lin, S; Mak, CK; Orth, PM; Yang, Y	1
Acsai, K; Csanády, M; Dézsi, L; Farkas, A; Farkas, AS; Forster, T; Orosz, S; Papp, JG; Tóth, A; Varró, A	1
Hamlin, RL; Keene, BW; Kijtawornrat, A; Nishijima, Y; Roche, BM	1
Gould, M; Thompson, C; Tsiperfal, A	1
Beekman, JD; Oros, A; van der Nagel, T; Volders, PG; Vos, MA	1
Attevelt, NJ; Beekman, JD; Chiba, K; Sugiyama, A; Takahara, A; Thomsen, MB; Vos, MA	1
Roukoz, H; Saliba, W	1
Beekman, JD; Maas, JN; Oros, A; Schoenmakers, M; Thomsen, MB; van Opstal, JM; Vos, MA	1
Dai, DZ; Dai, Y; Huang, ZJ; Ji, M; Li, N; Na, T	1
Grant, AO; Tranquillo, J	1
Baczkó, I; Lengyel, C; Papp, JG; Tábori, K; Varró, A	1
Thomsen, MB	1
Akiyama, T; Aktas, MK; Shah, AH	1
Brendorp, B; Burchardt, H; Elming, H; Køber, L; Pedersen, HS; Seibaek, M; Torp-Pedersen, C	1
Csanády, M; Csík, N; Farkas, A; Farkas, AS; Forster, T; Leprán, I; Makra, P; Papp, JG; Rudas, L; Varró, A; Vincze, D	1
Chartier, D; Diness, TG; Grunnet, M; Hansen, RS; Nattel, S; Olesen, SP; Qi, XY; Tsuji, Y; Yeh, YH	1
Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G	1
Cobbe, SM; Lip, G; Rae, AP; Sedgwick, ML	1
Roden, DM; Yang, T	1
MacNeil, DJ	1
D'Alonzo, AJ; Darbenzio, RB; Zhu, JL	1
Agner, E; Bloch-Thomsen, PE; Camm, AJ; Carlsen, J; Egstrup, K; Køber, L; Marchant, B; Møller, M; Sandøe, E; Torp-Pedersen, C; Videbaek, J	1
Rubin, SA	1
Leunissen, JD; Van Opstal, JM; Vos, MA; Wellens, HJ	1
Anderson, ME; Bonney, S; Mazur, A; Roden, DM	1
Barrett, TD; Driscoll, EM; Fischbach, PS; Hennan, JK; Lucchesi, BR; O'Neill, BP	1
El-Sherif, N; Kozhevnikov, DO; Restivo, M; Robotis, D; Yamamoto, K	1

Reviews

6 review(s) available for uk 68798 and Torsade de Pointes

Article	Year
Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity. Computer methods and programs in biomedicine, 2023, Volume: 242 Topics: Arrhythmias, Cardiac; DNA-Binding Proteins; Female; Humans; Male; Potassium; Sulfonamides; Torsades de Pointes	2023
Myocardial repolarization and drugs. Impossibility to predict the dominance of anti-arrhythmic over pro-arrhythmic effects of drugs due to differential and ventricular electrical remodeling. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2001, Volume: 1, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Disease Models, Animal; Humans; Phenethylamines; Sulfonamides; Tachycardia, Ventricular; Torsades de Pointes	2001
Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues. The American journal of cardiology, 2003, Mar-20, Volume: 91, Issue:6A Topics: Amiodarone; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart Conduction System; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Risk Assessment; Risk Factors; Sex Factors; Sotalol; Sulfonamides; Tachycardia; Torsades de Pointes	2003
A benefit-risk assessment of class III antiarrhythmic agents. Expert opinion on drug safety, 2004, Volume: 3, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Combined Modality Therapy; Defibrillators, Implantable; Dronedarone; Heart Conduction System; Humans; Hydantoins; Imidazolidines; Ion Transport; Life Tables; Membrane Potentials; Meta-Analysis as Topic; Phenethylamines; Piperazines; Risk Assessment; Sotalol; Sulfonamides; Survival Analysis; Torsades de Pointes; Treatment Outcome	2004
Dofetilide: a new class III antiarrhythmic agent. Expert review of cardiovascular therapy, 2007, Volume: 5, Issue:1 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiologic Techniques, Cardiac; Heart Failure; Humans; Phenethylamines; Randomized Controlled Trials as Topic; Sulfonamides; Tachycardia, Supraventricular; Torsades de Pointes; Ventricular Function, Left	2007
The side effect profile of class III antiarrhythmic drugs: focus on d,l-sotalol. The American journal of cardiology, 1997, Oct-23, Volume: 80, Issue:8A Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Female; Heart Conduction System; Heart Failure; Humans; Hypertension; Infant, Newborn; Phenethylamines; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Exposure Delayed Effects; Risk Factors; Sotalol; Sulfonamides; Survival Rate; Torsades de Pointes	1997

Trials

5 trial(s) available for uk 68798 and Torsade de Pointes

Article	Year
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. PloS one, 2016, Volume: 11, Issue:12 Topics: Adult; Biomarkers; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Heart; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Sodium; Sodium Channel Blockers; Sulfonamides; Torsades de Pointes; Verapamil	2016
Risk factors and predictors of Torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving Dofetilide. The American journal of cardiology, 2007, Sep-01, Volume: 100, Issue:5 Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Output, Low; Cause of Death; Double-Blind Method; Electrocardiography; Female; Forecasting; Heart Arrest; Humans; Male; Middle Aged; Myocardial Infarction; Phenethylamines; Placebos; Potassium Channel Blockers; Risk Factors; Sex Factors; Sulfonamides; Time Factors; Torsades de Pointes; Ventricular Dysfunction, Left	2007
Chemical cardioversion of atrial fibrillation with intravenous dofetilide. International journal of cardiology, 1995, Volume: 49, Issue:2 Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cross-Over Studies; Double-Blind Method; Electric Countershock; Electrocardiography, Ambulatory; Humans; Infusions, Intravenous; Middle Aged; Phenethylamines; Placebos; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Torsades de Pointes	1995
Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. The New England journal of medicine, 1999, Sep-16, Volume: 341, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Electrocardiography; Female; Heart Failure; Hospitalization; Humans; Male; Middle Aged; Phenethylamines; Secondary Prevention; Sulfonamides; Survival Analysis; Torsades de Pointes; Ventricular Dysfunction, Left	1999
Pause-dependent polymorphic ventricular tachycardia during long-term treatment with dofetilide: a placebo-controlled, implantable cardioverter-defibrillator-based evaluation. Journal of the American College of Cardiology, 2001, Mar-15, Volume: 37, Issue:4 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Defibrillators, Implantable; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Phenethylamines; Sulfonamides; Tachycardia, Ventricular; Torsades de Pointes	2001

Other Studies

66 other study(ies) available for uk 68798 and Torsade de Pointes

Article	Year
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
Assessment of Sotalol and Dofetilide Dosing at a Large Academic Medical Center. Journal of cardiovascular pharmacology and therapeutics, 2020, Volume: 25, Issue:5 Topics: Academic Medical Centers; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Boston; Drug Dosage Calculations; Drug Monitoring; Female; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Practice Patterns, Physicians'; Retrospective Studies; Risk Assessment; Risk Factors; Sotalol; Sulfonamides; Torsades de Pointes	2020
Drug-Induced QT Prolongation and Torsades de Pointes: An All-Exclusive Relationship or Time for an Amicable Separation? Drug safety, 2018, Volume: 41, Issue:1 Topics: Anti-Arrhythmia Agents; Cardiotonic Agents; Cnidarian Venoms; Drug-Related Side Effects and Adverse Reactions; False Positive Reactions; Humans; Long QT Syndrome; Phenethylamines; Sulfonamides; Torsades de Pointes	2018
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes. The Journal of toxicological sciences, 2017, Volume: 42, Issue:5 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cromakalim; Disease Models, Animal; Electrocardiography; Isoflurane; Long QT Syndrome; Phenethylamines; Pinacidil; Quinidine; Rabbits; Risk; Sulfonamides; Systole; Torsades de Pointes; Ventricular Pressure	2017
Safety of Oral Dofetilide Reloading for Treatment of Atrial Arrhythmias. Circulation. Arrhythmia and electrophysiology, 2017, Volume: 10, Issue:10 Topics: Administration, Oral; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Administration Schedule; Drug Dosage Calculations; Electrocardiography, Ambulatory; Female; Heart Atria; Heart Rate; Humans; Male; Medical Records; Middle Aged; Patient Admission; Phenethylamines; Predictive Value of Tests; Retrospective Studies; Risk Factors; Sulfonamides; Time Factors; Torsades de Pointes; Treatment Outcome	2017
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia. British journal of pharmacology, 2018, Volume: 175, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Myocytes, Cardiac; Phenethylamines; Pyridines; Sulfonamides; Torsades de Pointes; Triazoles	2018
Dofetilide dose reductions and discontinuations in women compared with men. Heart rhythm, 2018, Volume: 15, Issue:4 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Female; Humans; Incidence; Male; Middle Aged; North Carolina; Phenethylamines; Retrospective Studies; Risk Factors; Sex Factors; Sulfonamides; Torsades de Pointes	2018
Potentially modifiable factors of dofetilide-associated risk of torsades de pointes among hospitalized patients with atrial fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2019, Volume: 54, Issue:2 Topics: Academic Medical Centers; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Case-Control Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Rate; Hospitalization; Humans; Logistic Models; Long QT Syndrome; Male; Middle Aged; Multivariate Analysis; Observer Variation; Phenethylamines; Prognosis; Retrospective Studies; Risk Assessment; Sulfonamides; Survival Rate; Torsades de Pointes; Treatment Outcome	2019
Predicting critical drug concentrations and torsadogenic risk using a multiscale exposure-response simulator. Progress in biophysics and molecular biology, 2019, Volume: 144 Topics: Action Potentials; Dose-Response Relationship, Drug; Electrocardiography; Endocardium; Heart; Heart Rate; Humans; Models, Cardiovascular; Pericardium; Phenethylamines; Potassium; Purkinje Cells; Risk Assessment; Single-Cell Analysis; Sulfonamides; Torsades de Pointes	2019
Frequency of toxicity with chemical conversion of atrial fibrillation with dofetilide. The American journal of cardiology, 2013, Aug-15, Volume: 112, Issue:4 Topics: Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Chi-Square Distribution; Electric Countershock; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Recurrence; Retrospective Studies; Sulfonamides; Torsades de Pointes	2013
Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model. European journal of pharmacology, 2013, Nov-15, Volume: 720, Issue:1-3 Topics: Animals; Anisoles; Anti-Arrhythmia Agents; Atrioventricular Block; Disease Models, Animal; Dogs; Female; Male; Phenethylamines; Pyrrolidines; Sulfonamides; Torsades de Pointes	2013
The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs. British journal of pharmacology, 2014, Volume: 171, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Remodeling; Atrioventricular Block; Databases, Factual; Delayed Rectifier Potassium Channels; Disease Models, Animal; Disease Susceptibility; Dogs; Early Diagnosis; Electrocardiography; Female; Heart; Heart Rate; Male; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sulfonamides; Torsades de Pointes	2014
Assessment of efficacy of proarrhythmia biomarkers in isolated rabbit hearts with attenuated repolarization reserve. Journal of cardiovascular pharmacology, 2014, Volume: 64, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Biomarkers; Chromans; Dose-Response Relationship, Drug; Electrocardiography; Female; Phenethylamines; Rabbits; Sulfonamides; Torsades de Pointes	2014
Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Circulation, 2014, Jul-15, Volume: 130, Issue:3 Topics: 4-Aminopyridine; Action Potentials; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Female; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Models, Animal; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Phenethylamines; Phosphatidylinositol 3-Kinases; Potassium Channel Blockers; Proto-Oncogene Proteins c-akt; Risk Factors; Signal Transduction; Sulfonamides; Torsades de Pointes; Transfection	2014
AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model. Journal of cardiovascular electrophysiology, 2015, Volume: 26, Issue:1 Topics: Action Potentials; Anesthetics; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Flunarizine; Heart Conduction System; Heart Rate; Methoxamine; Phenethylamines; Rabbits; Sulfonamides; Time Factors; Torsades de Pointes	2015
Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations. British journal of pharmacology, 2015, Volume: 172, Issue:11 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Dogs; Electrophysiological Phenomena; Ganglionic Blockers; Heart Ventricles; Hexamethonium; Macaca fascicularis; Myocytes, Cardiac; Phenethylamines; Sulfonamides; Torsades de Pointes	2015
Electrocardiographic Predictors of Torsadogenic Risk During Dofetilide or Sotalol Initiation: Utility of a Novel T Wave Analysis Program. Cardiovascular drugs and therapy, 2015, Volume: 29, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Case-Control Studies; Electrocardiography; Female; Humans; Male; Middle Aged; Phenethylamines; Predictive Value of Tests; Software; Sotalol; Sulfonamides; Torsades de Pointes	2015
Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs. Circulation journal : official journal of the Japanese Circulation Society, 2016, May-25, Volume: 80, Issue:6 Topics: Action Potentials; Anesthesia; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Dogs; Phenethylamines; Risk; Streptomycin; Sulfonamides; Torsades de Pointes	2016
Pharmacologic Conversion during Dofetilide Treatment for Persistent Atrial Fibrillation. Pacing and clinical electrophysiology : PACE, 2017, Volume: 40, Issue:6 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Causality; Chronic Disease; Cohort Studies; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; New York; Phenethylamines; Retrospective Studies; Risk Factors; Sulfonamides; Torsades de Pointes; Treatment Outcome	2017
An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia. Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Haloperidol; Heart; Heart Rate; In Vitro Techniques; Phenethylamines; Rabbits; Sulfonamides; Torsades de Pointes	2008
Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Diet; Disease Models, Animal; Docosahexaenoic Acids; Female; Heart Conduction System; Kinetics; Perfusion; Phenethylamines; Rabbits; Sodium Channel Blockers; Sodium Channels; Sulfonamides; Torsades de Pointes	2008
Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles. British journal of pharmacology, 2008, Volume: 155, Issue:8 Topics: Animals; Chromans; Heart Ventricles; Male; Phenethylamines; Potassium Channel Blockers; Rabbits; Sulfonamides; Torsades de Pointes; Veratridine	2008
The role of the Na+/Ca2+ exchanger, I(Na) and I(CaL) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts. British journal of pharmacology, 2009, Volume: 156, Issue:6 Topics: Animals; Calcium Channels, L-Type; Chronic Disease; Coronary Circulation; Female; Heart Block; Heart Rate; In Vitro Techniques; Phenethylamines; Potassium Channel Blockers; Rabbits; Sodium Channels; Sodium-Calcium Exchanger; Sulfonamides; Torsades de Pointes	2009
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. Journal of the American College of Cardiology, 2010, Feb-23, Volume: 55, Issue:8 Topics: Acetanilides; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Dogs; Lidocaine; Models, Animal; Phenethylamines; Piperazines; Potassium Channel Blockers; Ranolazine; Sodium Channels; Sulfonamides; Torsades de Pointes	2010
Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model. Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:6 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Dogs; Female; Halothane; Heart Block; Isoflurane; Male; Phenethylamines; Sulfonamides; Thiopental; Torsades de Pointes	2010
Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in α(1) -adrenoceptor-stimulated, anaesthetized rabbits. British journal of pharmacology, 2010, Volume: 161, Issue:7 Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Baroreflex; Biomarkers; Electrocardiography; Female; Heart; Phenethylamines; Phenylephrine; Rabbits; Receptors, Adrenergic, alpha-1; Sulfonamides; Torsades de Pointes	2010
Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action. British journal of pharmacology, 2010, Volume: 161, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Calcium Signaling; Cell Line; Dogs; Flunarizine; Humans; Lidocaine; Mice; Myocytes, Cardiac; Phenethylamines; Sulfonamides; Torsades de Pointes; Verapamil	2010
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. British journal of pharmacology, 2012, Volume: 165, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Embryonic Stem Cells; Female; Fluoroquinolones; Heart; Heart Block; Humans; Methoxamine; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Quinolines; Rabbits; Sulfonamides; Torsades de Pointes; Ventricular Remodeling	2012
Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2012, Volume: 14, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Bradycardia; Dogs; Female; Male; Phenethylamines; Sulfonamides; Torsades de Pointes; Ventricular Remodeling	2012
Effects of K201 on repolarization and arrhythmogenesis in anesthetized chronic atrioventricular block dogs susceptible to dofetilide-induced torsade de pointes. European journal of pharmacology, 2011, Dec-15, Volume: 672, Issue:1-3 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Chronic Disease; Disease Susceptibility; Dogs; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Phenethylamines; Sulfonamides; Thiazepines; Time Factors; Torsades de Pointes	2011
Assessment of QT-prolonging drugs in the isolated normal and failing rabbit hearts. The Journal of toxicological sciences, 2012, Volume: 37, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Cisapride; Electrocardiography; Feasibility Studies; Glucose; Heart; Heart Failure; In Vitro Techniques; Male; Models, Animal; Phenethylamines; Quinidine; Rabbits; Sulfonamides; Torsades de Pointes; Tromethamine	2012
High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment. American journal of physiology. Heart and circulatory physiology, 2013, Jan-01, Volume: 304, Issue:1 Topics: Action Potentials; Animals; CHO Cells; Cisapride; Computer Simulation; Cricetinae; Cricetulus; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; High-Throughput Screening Assays; Humans; Kinetics; Long QT Syndrome; Markov Chains; Models, Cardiovascular; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Propanolamines; Protein Binding; Risk Assessment; Sulfonamides; Torsades de Pointes; Toxicity Tests; Transfection	2013
Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems. European journal of pharmacology, 2003, Apr-11, Volume: 466, Issue:1-2 Topics: Action Potentials; Animals; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dogs; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Famotidine; Guinea Pigs; Heart Block; Hemodynamics; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; In Vitro Techniques; Long QT Syndrome; Papillary Muscles; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG	2003
Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog. Cardiovascular research, 2003, Aug-01, Volume: 59, Issue:2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Bradycardia; Chymases; Dose-Response Relationship, Drug; Female; Heart Block; Humans; Hypertrophy, Left Ventricular; Irbesartan; Male; Peptidyl-Dipeptidase A; Phenethylamines; Potassium Channel Blockers; Serine Endopeptidases; Sulfonamides; Tetrazoles; Torsades de Pointes	2003
Evaluation of the dofetilide risk-management program. American heart journal, 2003, Volume: 146, Issue:5 Topics: Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Electrocardiography; Female; Guideline Adherence; Humans; Incidence; Male; Middle Aged; North Carolina; Phenethylamines; Practice Guidelines as Topic; Product Labeling; Program Evaluation; Risk Management; Sotalol; Sulfonamides; Torsades de Pointes	2003
Initiation and monitoring of class III antiarrhythmic agents. Journal of cardiovascular electrophysiology, 2003, Volume: 14, Issue:12 Suppl Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Administration Schedule; Drug Approval; Drug Labeling; Drug Monitoring; Drug Therapy, Computer-Assisted; Humans; Patient Care Management; Patient Care Team; Phenethylamines; Practice Guidelines as Topic; Sotalol; Sulfonamides; Torsades de Pointes	2003
Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced Torsades de Pointes. Journal of molecular and cellular cardiology, 2004, Volume: 37, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Arginine; Cell Line; Computer Simulation; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Homozygote; Humans; Leucine; Mutation, Missense; Patch-Clamp Techniques; Phenethylamines; Polymorphism, Single Nucleotide; Potassium Channels, Voltage-Gated; Rabbits; Risk Factors; Sulfonamides; Torsades de Pointes	2004
Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel. Journal of cardiovascular electrophysiology, 2004, Volume: 15, Issue:11 Topics: Animals; Cation Transport Proteins; Cisapride; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Ether-A-Go-Go Potassium Channels; Guinea Pigs; In Vitro Techniques; Loratadine; Male; Myocytes, Cardiac; Phenethylamines; Potassium Channels, Voltage-Gated; Sulfonamides; Time Factors; Torsades de Pointes	2004
Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs. European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1 Topics: Animals; Calcium Channel Blockers; Dogs; Electrocardiography; Ether-A-Go-Go Potassium Channels; Humans; Male; Phenethylamines; Potassium Channels; Sotalol; Sulfonamides; Torsades de Pointes; Verapamil	2005
Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes. Journal of cardiovascular electrophysiology, 2005, Volume: 16, Issue:8 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Hydantoins; Imidazolidines; Male; Phenethylamines; Piperazines; Rabbits; Sulfonamides; Torsades de Pointes	2005
Atypical proarrhythmia with dofetilide: monomorphic VT and exercise-induced torsade de pointes. Pacing and clinical electrophysiology : PACE, 2005, Volume: 28, Issue:8 Topics: Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Exercise Test; Humans; Male; Middle Aged; Phenethylamines; Sulfonamides; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Premature Complexes	2005
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale. Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Humans; Male; Myocardial Ischemia; Phenethylamines; Sulfonamides; Torsades de Pointes	2005
RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents. Cardiovascular research, 2006, Jun-01, Volume: 70, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Dose-Response Relationship, Drug; Female; Membrane Transport Modulators; Models, Animal; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Purkinje Fibers; Quaternary Ammonium Compounds; Rabbits; Sodium Channel Blockers; Sulfonamides; Torsades de Pointes	2006
Importance of extracardiac alpha1-adrenoceptor stimulation in assisting dofetilide to induce torsade de pointes in rabbit hearts. European journal of pharmacology, 2006, May-10, Volume: 537, Issue:1-3 Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart Rate; Heart Ventricles; In Vitro Techniques; Methoxamine; Phenethylamines; Rabbits; Receptors, Adrenergic, alpha-1; Regional Blood Flow; Sulfonamides; Torsades de Pointes	2006
Use of a failing rabbit heart as a model to predict torsadogenicity. Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 93, Issue:1 Topics: Amiodarone; Animals; Cardiac Output, Low; Cisapride; Dose-Response Relationship, Drug; Electrocardiography; Models, Animal; Phenethylamines; Quaternary Ammonium Compounds; Quinidine; Rabbits; Sulfonamides; Torsades de Pointes; Verapamil	2006
What is drug-induced long QT and what is a potential clinical consequence? Progress in cardiovascular nursing, 2006,Spring, Volume: 21, Issue:2 Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Monitoring; Electrocardiography; Humans; Long QT Syndrome; Male; Metabolic Clearance Rate; Nursing Assessment; Phenethylamines; Sulfonamides; Telemetry; Torsades de Pointes	2006
Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block. Heart rhythm, 2006, Volume: 3, Issue:11 Topics: Action Potentials; Anesthesia, General; Animals; Biphenyl Compounds; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Heart Block; Heart Rate; Heart Ventricles; Infusions, Intravenous; Male; Phenethylamines; Sulfonamides; Torsades de Pointes; Treatment Outcome	2006
No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. British journal of pharmacology, 2006, Volume: 149, Issue:8 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Arrhythmias, Cardiac; Aza Compounds; Azithromycin; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Electrophysiology; Fluoroquinolones; Heart Block; Heart Rate; Long QT Syndrome; Moxifloxacin; Phenethylamines; Quinolines; Sulfonamides; Torsades de Pointes	2006
Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovascular research, 2007, Feb-01, Volume: 73, Issue:3 Topics: Action Potentials; Acute Disease; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Electrocardiography; Female; Heart Block; Heart Conduction System; Heart Rate; Male; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Torsades de Pointes; Ventricular Remodeling	2007
Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits. Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:4 Topics: Algorithms; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Electrocardiography; Female; Guinea Pigs; Heart Rate; Long QT Syndrome; Male; Membrane Potentials; Methoxamine; Molecular Structure; Myocardial Contraction; Myocytes, Cardiac; Naphthalenes; Phenethylamines; Potassium Channels, Inwardly Rectifying; Rabbits; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Sulfonamides; Torsades de Pointes	2007
Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation. Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Guinea Pigs; Hydantoins; Imidazolidines; Myocytes, Cardiac; Nicardipine; Patch-Clamp Techniques; Phenethylamines; Piperazines; Rabbits; Sulfonamides; Torsades de Pointes	2007
Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes. British journal of pharmacology, 2007, Volume: 151, Issue:7 Topics: Animals; Blood Pressure; Chromans; Delayed Rectifier Potassium Channels; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Electrocardiography; Female; Heart Conduction System; Heart Rate; Infusions, Intravenous; Long QT Syndrome; Male; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rabbits; Sodium; Species Specificity; Sulfonamides; Torsades de Pointes	2007
Double pharmacological challenge on repolarization opens new avenues for drug safety research. British journal of pharmacology, 2007, Volume: 151, Issue:7 Topics: Animals; Chromans; Delayed Rectifier Potassium Channels; Dogs; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Humans; Long QT Syndrome; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rabbits; Risk Factors; Sulfonamides; Torsades de Pointes	2007
Dofetilide-induced long QT and torsades de pointes. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2007, Volume: 12, Issue:3 Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Risk Factors; Sulfonamides; Torsades de Pointes	2007
Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits. British journal of pharmacology, 2008, Volume: 153, Issue:1 Topics: Anesthesia; Anesthetics; Animals; Anti-Inflammatory Agents; Baroreflex; Blood Pressure; Chloralose; Female; Heart Rate; Pentobarbital; Phenethylamines; Propofol; Rabbits; Receptors, Adrenergic, alpha-1; Sulfonamides; Sympathetic Nervous System; Torsades de Pointes; Vagus Nerve	2008
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovascular research, 2008, Jul-01, Volume: 79, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Bradycardia; Cresols; Delayed Rectifier Potassium Channels; Disease Models, Animal; Electrocardiography; Female; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Phenylurea Compounds; Rabbits; Sulfonamides; Torsades de Pointes	2008
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes	1993
Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation, 1996, Feb-01, Volume: 93, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Electrophysiology; Extracellular Space; Heart; Humans; Mice; Myocardium; Phenethylamines; Potassium; Quinidine; Sulfonamides; Torsades de Pointes	1996
Effects of class III antiarrhythmic agents in an in vitro rabbit model of spontaneous torsades de pointe. European journal of pharmacology, 1999, Mar-12, Volume: 369, Issue:1 Topics: Acetylcholine; Action Potentials; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Heart; Heart Rate; In Vitro Techniques; Male; Methoxamine; Nadolol; Perfusion; Phenethylamines; Rabbits; Sulfonamides; Torsades de Pointes; Vasoconstrictor Agents; Vasodilator Agents	1999
Dofetilide for atrial fibrillation. The New England journal of medicine, 2000, Jan-27, Volume: 342, Issue:4 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Heart Failure; Hospitalization; Humans; Phenethylamines; Sulfonamides; Torsades de Pointes	2000
Dofetilide for atrial fibrillation. The Medical letter on drugs and therapeutics, 2000, May-15, Volume: 42, Issue:1078 Topics: Anti-Arrhythmia Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Anti-Ulcer Agents; Antifungal Agents; Atrial Fibrillation; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ketoconazole; Phenethylamines; Potassium Channel Blockers; Sulfamethoxazole; Sulfonamides; Torsades de Pointes; Trimethoprim	2000
Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias. European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Heart Block; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sulfonamides; Torsades de Pointes; Ventricular Function	2001
Tedisamil and dofetilide-induced torsades de pointes, rate and potassium dependence. British journal of pharmacology, 2001, Volume: 132, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dose-Response Relationship, Drug; Electrocardiography; Heart; In Vitro Techniques; Male; Phenethylamines; Potassium; Rabbits; Sulfonamides; Torsades de Pointes	2001
Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns. Circulation, 2002, Mar-05, Volume: 105, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Body Surface Potential Mapping; Cardiomegaly; Disease Models, Animal; Disease Susceptibility; Dogs; Dose-Response Relationship, Drug; Electrodes, Implanted; Electrophysiologic Techniques, Cardiac; Heart Block; Heart Conduction System; Membrane Potentials; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Torsades de Pointes	2002