Page last updated: 2024-08-25

uk 68798 and Long QT Syndrome

uk 68798 has been researched along with Long QT Syndrome in 69 studies

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (7.25)	18.2507
2000's	31 (44.93)	29.6817
2010's	25 (36.23)	24.3611
2020's	8 (11.59)	2.80

Authors

Authors	Studies
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Amin, AK; Billakanty, SR; Chopra, N; El-Zein, R; Fu, EY; Khan, ZA; LaBreck, ME; Luli, J; Roberts, C; Smith, A; Tyler, JD	1
Ackerman, MJ; Das, S; Hamrick, SK; Kim, M; Pradhananga, S; Sager, PT; Srinivasan, D; Tester, DJ	1
Aghasafari, P; Bekker, S; Clancy, CE; Dawson, JRD; DeMarco, KR; Jeng, MT; Noskov, SY; Vorobyov, I; Yang, PC; Yarov-Yarovoy, V	1
Knowles, D; Malloy, R; Ting, C	1
Charpentier, F; De Waard, M; De Waard, S; Forest, V; Gaborit, N; Lemarchand, P; Loussouarn, G; Mangoni, ME; Montnach, J; Nicolas, S; Ribeiro, B; Ronjat, M	1
Gabriele, M; Nguyen, MT; Zhu, E	1
Dibb, KM; Eisner, DA; Hutchings, DC; Madders, GWP; Pearman, CM; Trafford, AW; Woods, LS	1
Castagné, V; Goineau, S	1
Hondeghem, LM	1
Hamlin, RL; Kijtawornrat, A; Limprasutr, V; Meedech, P; Saengklub, N	1
Cheng, G; Han, W; Sun, C; Wu, J	1
Cui, Z; Kaplan, AV; Maloney, RW; Sangha, RS; Wang, SY; Welch, TD	1
Ackerman, MJ; Asirvatham, SJ; DeSimone, CV; Kapa, S; Kella, D; Lee, HC; Naksuk, N; Noseworthy, PA; Padmanabhan, D; Sugrue, AM	1
Blinova, K; Daluwatte, C; Patel, D; Schocken, D; Strauss, DG; Vicente, J; Wu, JC	1
Benson, C; Brown, R; Couderc, JP; Darpo, B; Dota, C; Ferber, G; Ferry, J; Jarugula, V; Keirns, J; Ortemann-Renon, C; Pham, T; Riley, S; Sarapa, N; Ticktin, M; Zareba, W	1
Adelstein, E; Barrington, W; Bazaz, R; Brumberg, G; Gera, N; Jain, SK; Mendenhall, GS; Nemec, J; Pray, C; Saba, S; Schwartzman, D; Voigt, A; Wang, NC	1
Clancy, CE; Romero, L; Saiz, J; Trenor, B; Yang, PC	1
Agusala, K; Caprio, T; Kulkarni, C; Oesterle, A; Passman, R; Subacius, H	1
Kim, JJ; Li, Q; Němec, J; Salama, G	1
Anyukhovsky, EP; Chauveau, S; Coronel, R; Danilo, PR; Janse, MJ; Meijborg, VM; Opthof, T; Rosen, MR	1
Crumb, WJ; Johannesen, L; Mason, JW; Pueyo, E; Stockbridge, N; Strauss, DG; Vicente, J	1
Fukushima, T; Hata, Y; Hisajima, N; Kano, M; Kinoshita, K; Nishida, N; Tabata, T	1
Cools, F; Danhof, M; Gallacher, DJ; Gotta, V; Morissette, P; Sannajust, F; van Ammel, K; van der Graaf, PH; Visser, SA	1
Blinova, K; Chan, D; Crumb, WJ; Erato, C; Florian, J; Guo, P; Hong, M; Johannesen, L; Lin, J; Mason, JW; Mutlib, A; Sanabria, C; Stockbridge, N; Stohlman, J; Strauss, DG; Ugander, M; Vicente, J; Waite-Labott, K; Wang, J	1
Anyukhovsky, EP; Chauveau, S; Cohen, IS; Coronel, R; Feinmark, SJ; Harleton, E; Janse, MJ; Jiang, YP; Lin, RZ; Opthof, T; Qiu, XS; Rahim, T; Rosen, MR; Rosen, TS	1
Beshaw, C; Casas, O; Couderc, JP; Niu, X; Pallas-Areny, R; Rosero, S; Serrano-Finetti, E; Zareba, W	1
Casarotto, E; Danhof, M; Della Pasqua, O; Dubois, VF	1
Hosseini, M; Johannesen, L; Mason, JW; Pueyo, E; Sager, PT; Strauss, DG; Vicente, J	1
Shah, Y; Steinberg, JS; Szepietowska, B	1
Barecki-Roach, M; Bass, AS; Friedrichs, GS; Haushalter, TM; Hayes, R; Pastino, G; Reynolds, DL	1
Hreiche, R; Morissette, P; Turgeon, J; Zakrzewski-Jakubiak, H	1
Andersson, B; Carlsson, L; Linhardt, G; Löfberg, L	1
Gong, PL; Liu, QN; Yang, XY; Zeng, FD; Zhang, L	1
Corrias, A; Ferrero, JM; Gomis-Tena, J; Gonzalez, R; Rodriguez, B; Saiz, J	1
Eldstrom, J; Es-Salah-Lamoureux, Z; Fedida, D; Fougere, RR; Rezazadeh, S	1
Antoons, G; Beekman, JD; Bourgonje, VJ; de Windt, LJ; Houtman, MJ; Miedema, LF; Schoenmakers, M; Sipido, K; van der Nagel, R; van Veen, TA; Vos, MA	1
Abi-Gerges, N; Boyett, MR; Davies, MR; Di Veroli, GY; Zhang, H	1
Brendorp, B; Elming, H; Køber, L; Torp-Pedersen, C	1
Duff, HJ; Guo, J; Lees-Miller, JP; Rancourt, DE; Roach, DE; Sheldon, RS; Somers, JR	1
Endoh, M; Ishii, K; Nagai, M; Takahashi, M	1
Hashimoto, K; Miyata, K; Nakamura, Y; Sato, S; Satoh, Y; Shimizu-Sasamata, M; Sugiyama, A; Takahara, A	1
Brendorp, B; Elming, H; Jun, L; Køber, L; Torp-Pedersen, C	2
Bauer, A; Becker, R; Donahue, JK; Katus, HA; Kelemen, K; Kraft, P; Schoels, W; Senges, JC; Voss, F	1
Jonker, DM; Jonsson, EN; Kenna, LA; Leishman, D; Milligan, PA; Wallis, R	1
Bradley, JA; Cass, JD; Chen, X; Dahm, CM; Engwall, MJ; Kadyszewski, E; Sun, Z; Zhou, J	1
Kamiya, K; Mitcheson, JS; Niwa, R; Sanguinetti, MC	1
Chen, XL; Ji, J; Kang, J; Rampe, DE; Reynolds, WP; Wang, H	1
Gould, M; Thompson, C; Tsiperfal, A	1
Attevelt, NJ; Beekman, JD; Chiba, K; Sugiyama, A; Takahara, A; Thomsen, MB; Vos, MA	1
Dai, DZ; Dai, Y; Huang, ZJ; Ji, M; Li, N; Na, T	1
Bauman, JL; Kehoe, RF; Leal, S; Mykytsey, A; Razminia, M; Saleem, M; Wang, T; Zheutlin, T	1
Baczkó, I; Lengyel, C; Papp, JG; Tábori, K; Varró, A	1
Thomsen, MB	1
Akiyama, T; Aktas, MK; Shah, AH	1
Chartier, D; Diness, TG; Grunnet, M; Hansen, RS; Nattel, S; Olesen, SP; Qi, XY; Tsuji, Y; Yeh, YH	1
Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T	1
Brown, AM; Cantù, F; Napolitano, C; Priori, SG; Schwartz, PJ	1
Chaudhary, A; Snyders, DJ	1
Cantù, F; Priori, SG; Schwartz, PJ	1
Cantù, F; Napolitano, C; Paganini, V; Priori, SG; Schwartz, PJ	1
Bianchi, L; Castaldo, P; Emmi, A; Janigro, D; Nerbonne, J; Robertson, GA; Schwartzkroin, PA; Taglialatela, M; Wenzel, HJ	1
Brendorp, B; Elming, H; Jensen, GB; Jun, L; Køber, L; Malik, M; Torp-Pedersen, C	1
Danilo, P; Gainullin, RZ; Pham, TV; Rosen, MR; Sosunov, EA	1
Bammert, A; Charpentier, F; Demolombe, S; Escande, D; Lande, G; Moorman, A	1
Ahn, S; Etienne, J; Friedrich, T; Ghadanfar, M; Massart, PE; Pouleur, H; Rousseau, MF; van Eyll, C	1
De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Somers, K	1
Pham, TV; Rosen, MR	1

Reviews

3 review(s) available for uk 68798 and Long QT Syndrome

Article	Year
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis. British journal of pharmacology, 2015, Volume: 172, Issue:17 Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sotalol; Sulfonamides; Telemetry; Translational Research, Biomedical	2015
Molecular biology of the long QT syndrome: impact on management. Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:8 Pt 2 Topics: Action Potentials; Adrenergic Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiotonic Agents; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Disease Models, Animal; Electrocardiography; Genetic Therapy; Guinea Pigs; Heart Rate; Humans; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Molecular Biology; Myocardium; Peptides; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Adrenergic; Risk Factors; Sodium Channel Blockers; Sodium Channels; Sulfonamides; Syncope; Tachycardia, Ventricular	1997
Sex, hormones, and repolarization. Cardiovascular research, 2002, Feb-15, Volume: 53, Issue:3 Topics: Aging; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Female; Gonadal Steroid Hormones; Humans; Ion Channels; Long QT Syndrome; Male; Myocardium; Phenethylamines; Potassium Channel Blockers; Rabbits; Receptors, Androgen; Receptors, Estrogen; Sex; Sulfonamides	2002

Trials

12 trial(s) available for uk 68798 and Long QT Syndrome

Article	Year
Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs. Clinical and translational science, 2019, Volume: 12, Issue:6 Topics: Action Potentials; Adult; Cardiotoxicity; Cell Differentiation; Cells, Cultured; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Induced Pluripotent Stem Cells; Long QT Syndrome; Male; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Primary Cell Culture; Sulfonamides; Toxicity Tests	2019
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study. Journal of clinical pharmacology, 2020, Volume: 60, Issue:1 Topics: Arrhythmias, Cardiac; Biomarkers; Cetirizine; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Conduction System; Heart Rate; Humans; Indoles; Ion Channels; Long QT Syndrome; Male; Moxifloxacin; Ondansetron; Phenethylamines; Quinine; Quinolizines; Risk Assessment; Sulfonamides	2020
Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil. Journal of the American Heart Association, 2015, Apr-13, Volume: 4, Issue:4 Topics: Adult; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Humans; Long QT Syndrome; Male; Phenethylamines; Quinidine; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil	2015
Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial. Clinical pharmacology and therapeutics, 2016, Volume: 99, Issue:2 Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Drug Therapy, Combination; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Moxifloxacin; Phenethylamines; Prospective Studies; Sodium Channel Blockers; Sulfonamides; Young Adult	2016
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. PloS one, 2016, Volume: 11, Issue:12 Topics: Adult; Biomarkers; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Heart; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Sodium; Sodium Channel Blockers; Sulfonamides; Torsades de Pointes; Verapamil	2016
Survival after withdrawal of dofetilide in patients with congestive heart failure and a short baseline QTc interval; a follow-up on the Diamond-CHF QT substudy. European heart journal, 2003, Volume: 24, Issue:3 Topics: Adult; Aged; Anti-Arrhythmia Agents; Double-Blind Method; Female; Follow-Up Studies; Heart Failure; Humans; Infant, Newborn; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Proportional Hazards Models; Risk Factors; Sulfonamides; Survival Analysis; Treatment Outcome; Ventricular Dysfunction, Left	2003
The prognostic value of QTc interval and QT dispersion following myocardial infarction in patients treated with or without dofetilide. Clinical cardiology, 2003, Volume: 26, Issue:5 Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Denmark; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Humans; Long QT Syndrome; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Phenethylamines; Prognosis; Proportional Hazards Models; Risk Factors; Sulfonamides; Survival Analysis; Systole; Treatment Outcome; Ventricular Dysfunction, Left	2003
Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function. Journal of cardiovascular pharmacology and therapeutics, 2007, Volume: 12, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Drug Monitoring; Female; Flecainide; Follow-Up Studies; Humans; Inpatients; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Propafenone; Recurrence; Sotalol; Sulfonamides; Tachycardia, Ventricular; Treatment Outcome; Ventricular Function, Left; Withholding Treatment	2007
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography. Journal of the American College of Cardiology, 1996, Volume: 27, Issue:1 Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides	1996
Qtc interval as a guide to select those patients with congestive heart failure and reduced left ventricular systolic function who will benefit from antiarrhythmic treatment with dofetilide. Circulation, 2001, Mar-13, Volume: 103, Issue:10 Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Double-Blind Method; Female; Heart Failure; Humans; Long QT Syndrome; Male; Middle Aged; Multivariate Analysis; Patient Selection; Phenethylamines; Prospective Studies; Sulfonamides; Survival Analysis; Treatment Outcome; Ventricular Function, Left	2001
Cardiac and hemodynamic effects of intravenous dofetilide in patients with heart failure. The American journal of cardiology, 2001, Jun-01, Volume: 87, Issue:11 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Double-Blind Method; Electrocardiography; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Long QT Syndrome; Male; Middle Aged; Myocardial Contraction; Phenethylamines; Sulfonamides; Ventricular Function, Left	2001
Effect of dofetilide on QT dispersion and the prognostic implications of changes in QT dispersion for patients with congestive heart failure. European journal of heart failure, 2002, Volume: 4, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Double-Blind Method; Electrocardiography; Endpoint Determination; Female; Follow-Up Studies; Heart Failure; Humans; Long QT Syndrome; Male; Middle Aged; Multivariate Analysis; Observer Variation; Phenethylamines; Potassium Channel Blockers; Prognosis; Reproducibility of Results; Sulfonamides; Survival Analysis; Treatment Outcome; Ventricular Dysfunction, Left	2002

Other Studies

54 other study(ies) available for uk 68798 and Long QT Syndrome

Article	Year
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Longitudinal QT Journal of cardiovascular electrophysiology, 2022, Volume: 33, Issue:6 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Humans; Long QT Syndrome; Male; Patient Discharge; Phenethylamines; Retrospective Studies; Sulfonamides	2022
SGK1 inhibition attenuates the action potential duration in reengineered heart cell models of drug-induced QT prolongation. Heart rhythm, 2023, Volume: 20, Issue:4 Topics: Action Potentials; Humans; Long QT Syndrome; Mexiletine; Myocytes, Cardiac; Sulfonamides	2023
A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm. Circulation research, 2020, 04-10, Volume: 126, Issue:8 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotoxicity; Cardiotoxins; Computer Simulation; Drug Discovery; ERG1 Potassium Channel; Female; Humans; Long QT Syndrome; Machine Learning; Male; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Protein Structure, Secondary; Sulfonamides; Topoisomerase II Inhibitors	2020
Assessment of Sotalol and Dofetilide Dosing at a Large Academic Medical Center. Journal of cardiovascular pharmacology and therapeutics, 2020, Volume: 25, Issue:5 Topics: Academic Medical Centers; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Boston; Drug Dosage Calculations; Drug Monitoring; Female; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Practice Patterns, Physicians'; Retrospective Studies; Risk Assessment; Risk Factors; Sotalol; Sulfonamides; Torsades de Pointes	2020
Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells. International journal of molecular sciences, 2020, Sep-28, Volume: 21, Issue:19 Topics: Action Potentials; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Cell Differentiation; ERG1 Potassium Channel; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Transport; Long QT Syndrome; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Scorpion Venoms; Sulfonamides	2020
The Use of Intravenous Lidocaine in the Setting of Chronic Dofetilide Overdose: A Case Report. Journal of pharmacy practice, 2022, Volume: 35, Issue:6 Topics: Alcoholism; Drug Overdose; Electrocardiography; Humans; Lidocaine; Long QT Syndrome; Substance Withdrawal Syndrome	2022
PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca Circulation research, 2021, 09-03, Volume: 129, Issue:6 Topics: Animals; Calcium; Calcium Signaling; Carbazoles; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Long QT Syndrome; Phenethylamines; Phosphodiesterase 5 Inhibitors; Potassium Channel Blockers; Protein Kinase Inhibitors; Protein Kinases; Sarcoplasmic Reticulum; Sheep; Sildenafil Citrate; Sodium; Sulfonamides	2021
Proarrhythmic risk assessment using conventional and new in vitro assays. Regulatory toxicology and pharmacology : RTP, 2017, Volume: 88 Topics: Action Potentials; Anti-Arrhythmia Agents; Arsenic; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Fluoroquinolones; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells; Long QT Syndrome; Moxifloxacin; Myocytes, Cardiac; Pentamidine; Phenethylamines; Risk Assessment; Sulfonamides	2017
Drug-Induced QT Prolongation and Torsades de Pointes: An All-Exclusive Relationship or Time for an Amicable Separation? Drug safety, 2018, Volume: 41, Issue:1 Topics: Anti-Arrhythmia Agents; Cardiotonic Agents; Cnidarian Venoms; Drug-Related Side Effects and Adverse Reactions; False Positive Reactions; Humans; Long QT Syndrome; Phenethylamines; Sulfonamides; Torsades de Pointes	2018
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes. The Journal of toxicological sciences, 2017, Volume: 42, Issue:5 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cromakalim; Disease Models, Animal; Electrocardiography; Isoflurane; Long QT Syndrome; Phenethylamines; Pinacidil; Quinidine; Rabbits; Risk; Sulfonamides; Systole; Torsades de Pointes; Ventricular Pressure	2017
F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels. Microscopy research and technique, 2018, Volume: 81, Issue:6 Topics: Cell Line; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Long QT Syndrome; Microscopy, Confocal; Mutation; Patch-Clamp Techniques; Phenethylamines; Plasmids; Potassium Channel Blockers; Sulfonamides	2018
Dofetilide-Associated QT Prolongation: Total Body Weight Versus Adjusted or Ideal Body Weight for Dosing. Journal of cardiovascular pharmacology, 2018, Volume: 72, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Drug Dosage Calculations; Female; Humans; Ideal Body Weight; Long QT Syndrome; Male; Middle Aged; Models, Biological; Phenethylamines; Retrospective Studies; Risk Factors; Sulfonamides	2018
Potentially modifiable factors of dofetilide-associated risk of torsades de pointes among hospitalized patients with atrial fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2019, Volume: 54, Issue:2 Topics: Academic Medical Centers; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Case-Control Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Rate; Hospitalization; Humans; Logistic Models; Long QT Syndrome; Male; Middle Aged; Multivariate Analysis; Observer Variation; Phenethylamines; Prognosis; Retrospective Studies; Risk Assessment; Sulfonamides; Survival Rate; Torsades de Pointes; Treatment Outcome	2019
Frequency of toxicity with chemical conversion of atrial fibrillation with dofetilide. The American journal of cardiology, 2013, Aug-15, Volume: 112, Issue:4 Topics: Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Chi-Square Distribution; Electric Countershock; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Recurrence; Retrospective Studies; Sulfonamides; Torsades de Pointes	2013
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of molecular and cellular cardiology, 2014, Volume: 72 Topics: Action Potentials; Anti-Arrhythmia Agents; Astemizole; Cisapride; Computer Simulation; Gene Expression; Genetic Predisposition to Disease; Heart Ventricles; Humans; Ion Channel Gating; Kinetics; Long QT Syndrome; Models, Statistical; Mutation; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Conformation; Severity of Illness Index; Sotalol; Sulfonamides; Terfenadine	2014
Risk prediction for adverse events during initiation of sotalol and dofetilide for the treatment of atrial fibrillation. Pacing and clinical electrophysiology : PACE, 2015, Volume: 38, Issue:4 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Illinois; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Prevalence; Retrospective Studies; Risk Factors; Sotalol; Sulfonamides; Treatment Outcome; Ventricular Fibrillation	2015
Synchronous systolic subcellular Ca2+-elevations underlie ventricular arrhythmia in drug-induced long QT type 2. Circulation. Arrhythmia and electrophysiology, 2015, Volume: 8, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Signaling; Disease Models, Animal; Female; Heart Rate; In Vitro Techniques; Long QT Syndrome; Myocytes, Cardiac; Perfusion; Phenethylamines; Rabbits; Sarcoplasmic Reticulum; Sulfonamides; Thiazepines; Time Factors; Voltage-Sensitive Dye Imaging	2015
Interventricular dispersion in repolarization causes bifid T waves in dogs with dofetilide-induced long QT syndrome. Heart rhythm, 2015, Volume: 12, Issue:6 Topics: Animals; Dogs; Electrocardiography; Long QT Syndrome; Male; Phenethylamines; Potassium Channel Blockers; Sulfonamides	2015
The Susceptibilities of Human Ether-à-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:5 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Ether-A-Go-Go Potassium Channels; Genotype; Heart; Heart Conduction System; HEK293 Cells; Humans; Hypokalemia; Ion Channel Gating; Kinetics; Long QT Syndrome; Mutation; Patch-Clamp Techniques; Phenethylamines; Phenotype; Potassium; Potassium Channel Blockers; Sulfonamides	2015
Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration. Circulation. Arrhythmia and electrophysiology, 2016, Volume: 9, Issue:4 Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Heart Ventricles; Infusions, Intravenous; Long QT Syndrome; Male; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Sodium; Sulfonamides	2016
The QT Scale: A Weight Scale Measuring the QTc Interval. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2017, Volume: 22, Issue:1 Topics: Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Sulfonamides	2017
Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies. British journal of pharmacology, 2016, Volume: 173, Issue:19 Topics: Animals; Binding Sites; Cells, Cultured; Cisapride; Consciousness; Dogs; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Fluoroquinolones; Humans; Long QT Syndrome; Male; Models, Animal; Models, Biological; Moxifloxacin; Phenethylamines; Structure-Activity Relationship; Sulfonamides	2016
Pharmacologic Conversion during Dofetilide Treatment for Persistent Atrial Fibrillation. Pacing and clinical electrophysiology : PACE, 2017, Volume: 40, Issue:6 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Causality; Chronic Disease; Cohort Studies; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; New York; Phenethylamines; Retrospective Studies; Risk Factors; Sulfonamides; Torsades de Pointes; Treatment Outcome	2017
The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys. British journal of pharmacology, 2008, Volume: 154, Issue:7 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Humans; Long QT Syndrome; Macaca fascicularis; Male; Models, Animal; Phenethylamines; Species Specificity; Sulfonamides; Telemetry	2008
Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs. Journal of cardiovascular pharmacology and therapeutics, 2009, Volume: 14, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Delayed Rectifier Potassium Channels; Domperidone; Female; Guinea Pigs; Heart Conduction System; Indapamide; Long QT Syndrome; Male; Phenethylamines; Potassium Channel Blockers; Sex Factors; Sexual Development; Sulfonamides; Time Factors; Verapamil	2009
Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo. Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Long QT Syndrome; Male; Methoxamine; Phenethylamines; Potassium Channel Blockers; Rabbits; Sulfonamides; Time Factors	2009
Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current. Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:11 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzylisoquinolines; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Female; Hypertrophy, Left Ventricular; In Vitro Techniques; Long QT Syndrome; Magnesium; Male; Myocytes, Cardiac; Neuromuscular Depolarizing Agents; Papillary Muscles; Patch-Clamp Techniques; Phenethylamines; Potassium; Potassium Channel Blockers; Rabbits; Sulfonamides; Tetrahydroisoquinolines	2009
Sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2010, Volume: 2010 Topics: Action Potentials; Aging; Anti-Arrhythmia Agents; Computer Simulation; Female; Heart Conduction System; Heart Ventricles; Humans; Long QT Syndrome; Male; Models, Cardiovascular; Myocytes, Cardiac; Phenethylamines; Sex Factors; Sulfonamides	2010
Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal. Heart rhythm, 2011, Volume: 8, Issue:8 Topics: DNA, Complementary; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluorometry; HEK293 Cells; Humans; Long QT Syndrome; Mutation; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Protein Transport; Sulfonamides; Transfection	2011
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart rhythm, 2012, Volume: 9, Issue:11 Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Benzylamines; Calcineurin; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomyopathy, Hypertrophic; Cyclosporine; Disease Models, Animal; Dogs; Isoproterenol; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Phenotype; Phosphorylation; Random Allocation; Sulfonamides; Ventricular Remodeling	2012
High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment. American journal of physiology. Heart and circulatory physiology, 2013, Jan-01, Volume: 304, Issue:1 Topics: Action Potentials; Animals; CHO Cells; Cisapride; Computer Simulation; Cricetinae; Cricetulus; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; High-Throughput Screening Assays; Humans; Kinetics; Long QT Syndrome; Markov Chains; Models, Cardiovascular; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Propanolamines; Protein Binding; Risk Assessment; Sulfonamides; Torsades de Pointes; Toxicity Tests; Transfection	2013
Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia. Molecular and cellular biology, 2003, Volume: 23, Issue:6 Topics: Age Factors; Animals; Arrhythmia, Sinus; Bradycardia; Cation Transport Proteins; Disease Models, Animal; DNA-Binding Proteins; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Targeting; Heart Ventricles; Ion Transport; Long QT Syndrome; Mice; Mice, Knockout; Myocardium; Patch-Clamp Techniques; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Isoforms; RNA, Messenger; Sulfonamides; Trans-Activators	2003
Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency. Cardiovascular research, 2003, Volume: 57, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Isoleucine; Long QT Syndrome; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sulfonamides; Xenopus	2003
Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems. European journal of pharmacology, 2003, Apr-11, Volume: 466, Issue:1-2 Topics: Action Potentials; Animals; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dogs; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Famotidine; Guinea Pigs; Heart Block; Hemodynamics; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; In Vitro Techniques; Long QT Syndrome; Papillary Muscles; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG	2003
Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome. Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:4 Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Chromans; Disease Models, Animal; Dogs; Electrocardiography; Female; Heart Block; Long QT Syndrome; Male; Phenethylamines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides; Time Factors; Ventricular Function	2004
A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data. Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:6 Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cation Transport Proteins; Cell Culture Techniques; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart Conduction System; Humans; Long QT Syndrome; Middle Aged; Models, Cardiovascular; Phenethylamines; Potassium Channels, Voltage-Gated; Sulfonamides	2005
QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome. British journal of pharmacology, 2005, Volume: 146, Issue:6 Topics: Action Potentials; Animals; Anti-Infective Agents; Area Under Curve; Arrhythmias, Cardiac; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channels, Inwardly Rectifying; Quinolines; Rabbits; Sulfonamides; Telemetry; Treatment Outcome	2005
Molecular determinants of HERG channel block. Molecular pharmacology, 2006, Volume: 69, Issue:5 Topics: DNA Primers; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Long QT Syndrome; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Recombinant Proteins; Sulfonamides	2006
Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs. Anesthesiology, 2006, Volume: 104, Issue:5 Topics: Action Potentials; Adrenergic beta-Antagonists; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Cell Separation; CHO Cells; Cricetinae; Drug Interactions; Guinea Pigs; Humans; In Vitro Techniques; Ion Channels; Long QT Syndrome; Methyl Ethers; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Sevoflurane; Sotalol; Sulfonamides	2006
What is drug-induced long QT and what is a potential clinical consequence? Progress in cardiovascular nursing, 2006,Spring, Volume: 21, Issue:2 Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Monitoring; Electrocardiography; Humans; Long QT Syndrome; Male; Metabolic Clearance Rate; Nursing Assessment; Phenethylamines; Sulfonamides; Telemetry; Torsades de Pointes	2006
No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. British journal of pharmacology, 2006, Volume: 149, Issue:8 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Arrhythmias, Cardiac; Aza Compounds; Azithromycin; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Electrophysiology; Fluoroquinolones; Heart Block; Heart Rate; Long QT Syndrome; Moxifloxacin; Phenethylamines; Quinolines; Sulfonamides; Torsades de Pointes	2006
Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits. Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:4 Topics: Algorithms; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Electrocardiography; Female; Guinea Pigs; Heart Rate; Long QT Syndrome; Male; Membrane Potentials; Methoxamine; Molecular Structure; Myocardial Contraction; Myocytes, Cardiac; Naphthalenes; Phenethylamines; Potassium Channels, Inwardly Rectifying; Rabbits; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Sulfonamides; Torsades de Pointes	2007
Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes. British journal of pharmacology, 2007, Volume: 151, Issue:7 Topics: Animals; Blood Pressure; Chromans; Delayed Rectifier Potassium Channels; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Electrocardiography; Female; Heart Conduction System; Heart Rate; Infusions, Intravenous; Long QT Syndrome; Male; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rabbits; Sodium; Species Specificity; Sulfonamides; Torsades de Pointes	2007
Double pharmacological challenge on repolarization opens new avenues for drug safety research. British journal of pharmacology, 2007, Volume: 151, Issue:7 Topics: Animals; Chromans; Delayed Rectifier Potassium Channels; Dogs; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Humans; Long QT Syndrome; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rabbits; Risk Factors; Sulfonamides; Torsades de Pointes	2007
Dofetilide-induced long QT and torsades de pointes. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2007, Volume: 12, Issue:3 Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Risk Factors; Sulfonamides; Torsades de Pointes	2007
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovascular research, 2008, Jul-01, Volume: 79, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Bradycardia; Cresols; Delayed Rectifier Potassium Channels; Disease Models, Animal; Electrocardiography; Female; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Phenylurea Compounds; Rabbits; Sulfonamides; Torsades de Pointes	2008
Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome. Circulation research, 1996, Volume: 78, Issue:6 Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Intercellular Signaling Peptides and Proteins; Isoproterenol; Long QT Syndrome; Mexiletine; Mutation; Peptides; Phenethylamines; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Adrenergic, beta; Sodium Channel Blockers; Sodium Channels; Sulfonamides	1996
High affinity open channel block by dofetilide of HERG expressed in a human cell line. Molecular pharmacology, 1996, Volume: 49, Issue:6 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Trans-Activators; Transcriptional Regulator ERG; Transfection	1996
The long QT syndrome: new diagnostic and therapeutic approach in the era of molecular biology. Schweizerische medizinische Wochenschrift, 1996, Oct-12, Volume: 126, Issue:41 Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Ventricles; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Peptides; Phenethylamines; Point Mutation; Potassium Channels; Potassium Channels, Voltage-Gated; Sea Anemones; Sodium Channels; Sulfonamides; Trans-Activators; Transcriptional Regulator ERG	1996
Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, May-15, Volume: 20, Issue:10 Topics: Animals; Anti-Arrhythmia Agents; Astrocytes; Cation Transport Proteins; Cell Communication; Cesium; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; Ether-A-Go-Go Potassium Channels; Gene Expression; Heart; Hippocampus; In Vitro Techniques; Long QT Syndrome; Male; Membrane Potentials; Microscopy, Electron; Neurons; Oligonucleotide Probes; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Sulfonamides	2000
Impact of sex and gonadal steroids on prolongation of ventricular repolarization and arrhythmias induced by I(K)-blocking drugs. Circulation, 2001, May-01, Volume: 103, Issue:17 Topics: Action Potentials; Animals; Castration; Cation Transport Proteins; Chromans; Dihydrotestosterone; Endocardium; Estradiol; Ether-A-Go-Go Potassium Channels; Female; Isoflavones; Long QT Syndrome; Male; Papillary Muscles; Pericardium; Phenethylamines; Phytoestrogens; Plant Preparations; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Rabbits; Sex Factors; Sulfonamides	2001
Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part II: Pharmacological profile. Cardiovascular research, 2001, Volume: 50, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Cyclopropanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Long QT Syndrome; Mice; Mice, Transgenic; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sodium Channel Blockers; Sulfonamides	2001
Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model. Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:5 Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Electrocardiography; Female; Heart Rate; Incidence; Long QT Syndrome; Male; Methoxamine; Models, Cardiovascular; Phenethylamines; Rabbits; Receptors, Adrenergic, alpha-1; Risk Factors; Sex Factors; Sulfonamides; Treatment Outcome; Women's Health	2001