Page last updated: 2024-08-25

uk 68798 and Disease Models, Animal

uk 68798 has been researched along with Disease Models, Animal in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (27.66)	18.2507
2000's	20 (42.55)	29.6817
2010's	13 (27.66)	24.3611
2020's	1 (2.13)	2.80

Authors

Authors	Studies
Baizman, ER; Becker, C; Bell, RH; Birsner, NC; Bohnet, EA; Busacca, CA; Carabateas, PM; Chadwick, CC; Gruett, MD; Johnson, RE	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Hamlin, RL; Kijtawornrat, A; Limprasutr, V; Meedech, P; Saengklub, N	1
Buhl, R; Carstensen, H; Flethøj, M; Haugaard, MM; Hesselkilde, EZ; Jespersen, T; Kanters, JK; Kjær, L; Pehrson, S	1
Buhl, R; Carlson, J; Carstensen, H; Flethøj, M; Haugaard, MM; Hesselkilde, EZ; Jespersen, T; Pehrson, S; Platonov, PG	1
Beekman, JD; Tieland, RG; van der Heyden, MA; Varkevisser, R; Vos, MA	2
Beekman, HD; Bourgonje, VJ; Oosterhoff, P; Schoenmakers, M; Stams, TR; van der Nagel, R; van Opstal, JM; Vos, MA	1
Kim, JJ; Li, Q; Němec, J; Salama, G	1
Anyukhovsky, EP; Chauveau, S; Cohen, IS; Coronel, R; Feinmark, SJ; Harleton, E; Janse, MJ; Jiang, YP; Lin, RZ; Opthof, T; Qiu, XS; Rahim, T; Rosen, MR; Rosen, TS	1
Dhein, S; Mohr, FW; Perlitz, F	1
David, M; Dujardin, KS; Dumotier, B; Guizy, M; Hondeghem, LM; Valenzuela, C	1
Gong, PL; Liu, QN; Yang, XY; Zeng, FD; Zhang, L	1
Dai, DZ; Dai, Y; Hamed, KH; Hu, C; Yu, F	1
Beekman, JD; de Boer, TP; Duker, G; Houtman, MJ; Jonsson, MK; Nalos, L; Peschar, M; Rook, MB; Sartipy, P; Thomsen, MB; van der Heyden, MA; van der Nagel, R; van Veen, TA; Varkevisser, R; Vos, MA	1
Carlsson, LG; Crijns, HJ; de Jong, MM; Johnson, DM; Volders, PG	1
Antoons, G; Beekman, JD; Bourgonje, VJ; de Windt, LJ; Houtman, MJ; Miedema, LF; Schoenmakers, M; Sipido, K; van der Nagel, R; van Veen, TA; Vos, MA	1
Crijns, HJ; Vos, MA	1
Duff, HJ; Guo, J; Lees-Miller, JP; Rancourt, DE; Roach, DE; Sheldon, RS; Somers, JR	1
Bauer, A; Becker, R; Donahue, JK; Katus, HA; Kelemen, K; Kraft, P; Schoels, W; Senges, JC; Voss, F	1
Chandra, P; Danilo, P; Kim, HY; Lee, K; Rosen, MR; Rosen, TS; Yeom, ZH	1
Carlsson, L; Kowey, PR; Liu, T; Wu, Y; Yan, GX	1
Bradley, JA; Cass, JD; Chen, X; Dahm, CM; Engwall, MJ; Kadyszewski, E; Sun, Z; Zhou, J	1
Cvetanovic, I; Ke, X; Lin, C; Ranade, V; Somberg, J	1
Beekman, JD; Oros, A; van der Nagel, T; Volders, PG; Vos, MA	1
Brendel, J; Gögelein, H; Linz, DK; Rütten, H; Steinmeyer, K; Wirth, KJ	1
Chartier, D; Diness, TG; Grunnet, M; Hansen, RS; Nattel, S; Olesen, SP; Qi, XY; Tsuji, Y; Yeh, YH	1
De Clerck, F; Lu, HR; Remeysen, P	1
Chi, L; Friedrichs, GS; Green, AL; Lucchesi, BR	1
Andersen, HR; Christiansen, N; Knudsen, LL; Simonsen, I; Thomsen, PE; Wiggers, H	1
Bril, A; Feuerstein, GZ; Gout, B; Nichols, AJ	1
Cha, Y; Feld, GK; Sawhney, N; Shahrokni, S; Wales, A; Wolf, P	1
Chen, J; Eto, K; Hashimoto, K; Ni, C; Xue, Y	1
Cantù, F; Napolitano, C; Paganini, V; Priori, SG; Schwartz, PJ	1
Cobbe, SM; Kane, KA; McIntosh, MA; Rankin, AC	1
Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Yonezawa, T	1
Gillis, AM; Kulisz, E; Lester, WM; Mathison, HJ	1
Carnes, CA; Mehdirad, AA; Nelson, SD	1
Beatch, GN; Davis, DR; Dickenson, DR; Tang, AS	1
Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE	1
Bénardeau, A; Li, D; Nattel, S	1
DiMarco, JP; Mounsey, JP	1
Doshi, SK; Singh, BN	1
Leunissen, JD; Van Opstal, JM; Vos, MA; Wellens, HJ	1
De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Somers, K	1
El-Sherif, N; Kozhevnikov, DO; Restivo, M; Robotis, D; Yamamoto, K	1
Doggrell, SA; Nand, V	1

Reviews

5 review(s) available for uk 68798 and Disease Models, Animal

Article	Year
Myocardial repolarization and drugs. Impossibility to predict the dominance of anti-arrhythmic over pro-arrhythmic effects of drugs due to differential and ventricular electrical remodeling. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2001, Volume: 1, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Disease Models, Animal; Humans; Phenethylamines; Sulfonamides; Tachycardia, Ventricular; Torsades de Pointes	2001
Molecular biology of the long QT syndrome: impact on management. Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:8 Pt 2 Topics: Action Potentials; Adrenergic Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiotonic Agents; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Disease Models, Animal; Electrocardiography; Genetic Therapy; Guinea Pigs; Heart Rate; Humans; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Molecular Biology; Myocardium; Peptides; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Adrenergic; Risk Factors; Sodium Channel Blockers; Sodium Channels; Sulfonamides; Syncope; Tachycardia, Ventricular	1997
Dofetilide enhances shock-induced extension of refractoriness and lowers defibrillation threshold. The Canadian journal of cardiology, 1999, Volume: 15, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Electric Countershock; Humans; Phenethylamines; Shock, Cardiogenic; Sulfonamides	1999
Cardiovascular drugs. Dofetilide. Circulation, 2000, Nov-21, Volume: 102, Issue:21 Topics: Action Potentials; Administration, Oral; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Controlled Clinical Trials as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Humans; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Reaction Time; Sulfonamides; Treatment Outcome; Ventricular Fibrillation	2000
Pure class III antiarrhythmic drugs: focus on dofetilide. Journal of cardiovascular pharmacology and therapeutics, 2000, Volume: 5, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Electrophysiology; Heart Failure; Humans; Phenethylamines; Sulfonamides	2000

Trials

1 trial(s) available for uk 68798 and Disease Models, Animal

Article	Year
Dofetilide reduces the incidence of ventricular fibrillation during acute myocardial ischaemia. A randomised study in pigs. Cardiovascular research, 1994, Volume: 28, Issue:11 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease Models, Animal; Electrocardiography; Myocardial Ischemia; Phenethylamines; Potassium Channels; Sulfonamides; Swine; Ventricular Fibrillation	1994

Other Studies

41 other study(ies) available for uk 68798 and Disease Models, Animal

Article	Year
4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: novel antiarrhythmic agents. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepines; Cats; Disease Models, Animal; Dogs; Guinea Pigs; Heart Ventricles; Male; Myocardial Contraction; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Sodium Channels; Structure-Activity Relationship	1993
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes. The Journal of toxicological sciences, 2017, Volume: 42, Issue:5 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cromakalim; Disease Models, Animal; Electrocardiography; Isoflurane; Long QT Syndrome; Phenethylamines; Pinacidil; Quinidine; Rabbits; Risk; Sulfonamides; Systole; Torsades de Pointes; Ventricular Pressure	2017
Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. Journal of cardiovascular pharmacology, 2018, Volume: 71, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Drug Combinations; Female; Heart Rate; Horses; Infusions, Intravenous; Male; Phenethylamines; Ranolazine; Sulfonamides	2018
Effects of dofetilide and ranolazine on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation. Journal of cardiovascular electrophysiology, 2019, Volume: 30, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; Horses; Male; Phenethylamines; Potassium Channel Blockers; Ranolazine; Sodium Channel Blockers; Sulfonamides; Time Factors	2019
Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model. European journal of pharmacology, 2013, Nov-15, Volume: 720, Issue:1-3 Topics: Animals; Anisoles; Anti-Arrhythmia Agents; Atrioventricular Block; Disease Models, Animal; Dogs; Female; Male; Phenethylamines; Pyrrolidines; Sulfonamides; Torsades de Pointes	2013
The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs. British journal of pharmacology, 2014, Volume: 171, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Remodeling; Atrioventricular Block; Databases, Factual; Delayed Rectifier Potassium Channels; Disease Models, Animal; Disease Susceptibility; Dogs; Early Diagnosis; Electrocardiography; Female; Heart; Heart Rate; Male; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sulfonamides; Torsades de Pointes	2014
AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model. Journal of cardiovascular electrophysiology, 2015, Volume: 26, Issue:1 Topics: Action Potentials; Anesthetics; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Flunarizine; Heart Conduction System; Heart Rate; Methoxamine; Phenethylamines; Rabbits; Sulfonamides; Time Factors; Torsades de Pointes	2015
Synchronous systolic subcellular Ca2+-elevations underlie ventricular arrhythmia in drug-induced long QT type 2. Circulation. Arrhythmia and electrophysiology, 2015, Volume: 8, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Signaling; Disease Models, Animal; Female; Heart Rate; In Vitro Techniques; Long QT Syndrome; Myocytes, Cardiac; Perfusion; Phenethylamines; Rabbits; Sarcoplasmic Reticulum; Sulfonamides; Thiazepines; Time Factors; Voltage-Sensitive Dye Imaging	2015
Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration. Circulation. Arrhythmia and electrophysiology, 2016, Volume: 9, Issue:4 Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Heart Ventricles; Infusions, Intravenous; Long QT Syndrome; Male; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Sodium; Sulfonamides	2016
An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia. Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Haloperidol; Heart; Heart Rate; In Vitro Techniques; Phenethylamines; Rabbits; Sulfonamides; Torsades de Pointes	2008
Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Diet; Disease Models, Animal; Docosahexaenoic Acids; Female; Heart Conduction System; Kinetics; Perfusion; Phenethylamines; Rabbits; Sodium Channel Blockers; Sodium Channels; Sulfonamides; Torsades de Pointes	2008
Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current. The American journal of Chinese medicine, 2010, Volume: 38, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzylisoquinolines; Calcium Channels, L-Type; Calcium Signaling; Cardiomegaly; Disease Models, Animal; Heart; Menispermum; Muscle Cells; Patch-Clamp Techniques; Phenethylamines; Phytotherapy; Plant Extracts; Potassium; Rabbits; Rhizome; Sulfonamides; Time Factors	2010
CPU228, a derivative of dofetilide, relieves cardiac dysfunction by normalizing FKBP12.6, NADPH oxidase and protein kinase C epsilon in the myocardium. The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Heart Failure; Isoproterenol; Male; NADPH Oxidases; Naphthalenes; Oxidative Stress; Phenethylamines; Phosphorylation; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Sulfonamides; Tacrolimus Binding Proteins; Up-Regulation	2010
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. British journal of pharmacology, 2012, Volume: 165, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Embryonic Stem Cells; Female; Fluoroquinolones; Heart; Heart Block; Humans; Methoxamine; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Quinolines; Rabbits; Sulfonamides; Torsades de Pointes; Ventricular Remodeling	2012
Reduced ventricular proarrhythmic potential of the novel combined ion-channel blocker AZD1305 versus dofetilide in dogs with remodeled hearts. Circulation. Arrhythmia and electrophysiology, 2012, Volume: 5, Issue:1 Topics: Animals; Atrioventricular Block; Azabicyclo Compounds; Carbamates; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Female; Follow-Up Studies; Heart Rate; Male; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Treatment Outcome; Ventricular Remodeling	2012
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart rhythm, 2012, Volume: 9, Issue:11 Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Benzylamines; Calcineurin; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomyopathy, Hypertrophic; Cyclosporine; Disease Models, Animal; Dogs; Isoproterenol; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Phenotype; Phosphorylation; Random Allocation; Sulfonamides; Ventricular Remodeling	2012
Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia. Molecular and cellular biology, 2003, Volume: 23, Issue:6 Topics: Age Factors; Animals; Arrhythmia, Sinus; Bradycardia; Cation Transport Proteins; Disease Models, Animal; DNA-Binding Proteins; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Targeting; Heart Ventricles; Ion Transport; Long QT Syndrome; Mice; Mice, Knockout; Myocardium; Patch-Clamp Techniques; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Isoforms; RNA, Messenger; Sulfonamides; Trans-Activators	2003
Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome. Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:4 Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Chromans; Disease Models, Animal; Dogs; Electrocardiography; Female; Heart Block; Long QT Syndrome; Male; Phenethylamines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides; Time Factors; Ventricular Function	2004
Evaluation of KCB-328, a new IKr blocking antiarrhythmic agent in pacing induced canine atrial fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2004, Volume: 6, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Heart Atria; Heart Ventricles; Phenethylamines; Potassium Channel Blockers; Propafenone; Random Allocation; Sodium Channel Blockers; Sulfonamides	2004
Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes. Journal of cardiovascular electrophysiology, 2005, Volume: 16, Issue:8 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Hydantoins; Imidazolidines; Male; Phenethylamines; Piperazines; Rabbits; Sulfonamides; Torsades de Pointes	2005
QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome. British journal of pharmacology, 2005, Volume: 146, Issue:6 Topics: Action Potentials; Animals; Anti-Infective Agents; Area Under Curve; Arrhythmias, Cardiac; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channels, Inwardly Rectifying; Quinolines; Rabbits; Sulfonamides; Telemetry; Treatment Outcome	2005
The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents. Cardiology, 2007, Volume: 108, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Disease Models, Animal; Electrophysiology; Extracellular Matrix; Female; Hydantoins; Hyperkalemia; Imidazolidines; Oocytes; Phenethylamines; Piperazines; Potassium Channels; Potassium Channels, Voltage-Gated; Probability; Sensitivity and Specificity; Sotalol; Sulfonamides; Xenopus laevis	2007
Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block. Heart rhythm, 2006, Volume: 3, Issue:11 Topics: Action Potentials; Anesthesia, General; Animals; Biphenyl Compounds; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Heart Block; Heart Rate; Heart Ventricles; Infusions, Intravenous; Male; Phenethylamines; Sulfonamides; Torsades de Pointes; Treatment Outcome	2006
In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231. Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:4 Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Function; Blood Flow Velocity; Carbachol; Cardiotonic Agents; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Female; Goats; Guinea Pigs; Heart Atria; Heart Ventricles; Humans; Inhibitory Concentration 50; Ion Channels; Male; Myocytes, Cardiac; Papillary Muscles; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides; Swine; Time Factors	2007
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovascular research, 2008, Jul-01, Volume: 79, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Bradycardia; Cresols; Delayed Rectifier Potassium Channels; Disease Models, Animal; Electrocardiography; Female; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Phenylurea Compounds; Rabbits; Sulfonamides; Torsades de Pointes	2008
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil	1995
Antifibrillatory effects of clofilium in the rabbit isolated heart. British journal of pharmacology, 1994, Volume: 113, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Disease Models, Animal; Glyburide; Heart; Hydroxy Acids; In Vitro Techniques; Myocardium; Oxygen Consumption; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Quaternary Ammonium Compounds; Rabbits; Refractory Period, Electrophysiological; Sulfonamides; Ventricular Fibrillation; Ventricular Pressure	1994
Antifibrillatory effects of BRL-32872 in anesthetized Yucatan minipigs with regional myocardial ischemia. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:4 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Benzamides; Disease Models, Animal; Flecainide; Injections, Intravenous; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenethylamines; Sulfonamides; Swine; Swine, Miniature; Ventricular Fibrillation	1995
Electrophysiologic effects of the new class III antiarrhythmic drug dofetilide compared to the class IA antiarrhythmic drug quinidine in experimental canine atrial flutter: role of dispersion of refractoriness in antiarrhythmic efficacy. Journal of cardiovascular electrophysiology, 1996, Volume: 7, Issue:9 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Flutter; Disease Models, Animal; Dogs; Electrocardiography; Heart Conduction System; Phenethylamines; Quinidine; Sulfonamides; Treatment Outcome	1996
Effects of dofetilide, a class III antiarrhythmic drug, on various ventricular arrhythmias in dogs. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Digitalis; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Epinephrine; Female; Male; Myocardial Infarction; Myocardial Reperfusion; Phenethylamines; Plants, Medicinal; Plants, Toxic; Sulfonamides; Tachycardia, Ventricular; Ventricular Fibrillation	1996
Action potential prolongation and potassium currents in left-ventricular myocytes isolated from hypertrophied rabbit hearts. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:1 Topics: Action Potentials; Animals; Barium Compounds; Cadmium Chloride; Cells, Cultured; Chlorides; Disease Models, Animal; Endocardium; Hypertension; Hypertrophy, Left Ventricular; Male; Patch-Clamp Techniques; Pericardium; Perinephritis; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Rabbits; Sulfonamides; Ventricular Function	1998
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs. Japanese journal of pharmacology, 1998, Volume: 76, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Heart Conduction System; Male; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides; Vagus Nerve	1998
Dispersion of ventricular repolarization in left ventricular hypertrophy: influence of afterload and dofetilide. Journal of cardiovascular electrophysiology, 1998, Volume: 9, Issue:9 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Electrocardiography; Hypertrophy, Left Ventricular; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Potassium Channel Blockers; Rabbits; Sulfonamides; Ventricular Pressure	1998
The influence of specific and nonspecific potassium current blockade on the defibrillation energy requirement of biphasic shock. Pacing and clinical electrophysiology : PACE, 1999, Volume: 22, Issue:1 Pt 2 Topics: Action Potentials; Aminobenzoates; Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds, Heterocyclic; Defibrillators, Implantable; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric Countershock; Electrocardiography; Female; Heart Rate; Infusions, Intravenous; Male; Phenethylamines; Pilot Projects; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Treatment Outcome; Ventricular Fibrillation	1999
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 223, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Female; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Male; Methoxamine; Phenethylamines; Piperazines; Procainamide; Quaternary Ammonium Compounds; Rabbits; Sotalol; Sulfonamides	2000
Contrasting efficacy of dofetilide in differing experimental models of atrial fibrillation. Circulation, 2000, Jul-04, Volume: 102, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Pressure; Disease Models, Animal; Dogs; Electrocardiography; Heart Failure; Heart Ventricles; Pacemaker, Artificial; Pericardium; Phenethylamines; Sulfonamides; Ventricular Remodeling	2000
Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias. European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Heart Block; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sulfonamides; Torsades de Pointes; Ventricular Function	2001
Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model. Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:5 Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Electrocardiography; Female; Heart Rate; Incidence; Long QT Syndrome; Male; Methoxamine; Models, Cardiovascular; Phenethylamines; Rabbits; Receptors, Adrenergic, alpha-1; Risk Factors; Sex Factors; Sulfonamides; Treatment Outcome; Women's Health	2001
Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns. Circulation, 2002, Mar-05, Volume: 105, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Body Surface Potential Mapping; Cardiomegaly; Disease Models, Animal; Disease Susceptibility; Dogs; Dose-Response Relationship, Drug; Electrodes, Implanted; Electrophysiologic Techniques, Cardiac; Heart Block; Heart Conduction System; Membrane Potentials; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Torsades de Pointes	2002
Effects of dofetilide on cardiovascular tissues from normo- and hypertensive rats. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:5 Topics: Animals; Aorta; Blood Pressure; Blood Vessels; Cardiac Output, Low; Cardiomegaly; Disease Models, Animal; Electric Stimulation; Heart Rate; Heart Ventricles; Hypertension; In Vitro Techniques; Mesenteric Arteries; Myocardial Contraction; Phenethylamines; Portal Vein; Potassium Channel Blockers; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sulfonamides	2002