Page last updated: 2024-08-25

uk 68798 and Arrhythmia

uk 68798 has been researched along with Arrhythmia in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (10.99)	18.2507
2000's	40 (43.96)	29.6817
2010's	30 (32.97)	24.3611
2020's	11 (12.09)	2.80

Authors

Authors	Studies
Baizman, ER; Becker, C; Bell, RH; Birsner, NC; Bohnet, EA; Busacca, CA; Carabateas, PM; Chadwick, CC; Gruett, MD; Johnson, RE	1
Jia, L; Sun, H	1
Jacob, S; Nichols, J; Prousi, G; Smith, S; Tanner, H	1
Beekman, HDM; Bossu, A; Bourgonje, V; Dunnink, A; Meine, M; Oros, A; Salden, OA; Stams, T; Ter Horst, I; van Weperen, VYH; Vos, MA	1
Dobrev, D; Grundland, A; Heijman, J; Meier, S; Volders, PGA	1
Baroudi, S; Basset, M; Benito, S; Dayan, F; Koloskoff, K; Llopis-Lorente, J; Mora, MT; Romero, L; Saiz, J; Trenor, B	1
Shen, C; Stabenau, HF; Tereshchenko, LG; Waks, JW	1
Brelidze, TI; Rybka, V; Shults, NV; Suzuki, YJ	1
Burattini, L; Laratta, R; Marcantoni, I; Mascia, G; Morettini, M; Nasim, A; Ricciardi, L; Sbrollini, A	1
Aghasafari, P; Bekker, S; Clancy, CE; Dawson, JRD; DeMarco, KR; Jeng, MT; Noskov, SY; Vorobyov, I; Yang, PC; Yarov-Yarovoy, V	1
Becker, N; Brinkwirth, N; Doi, M; Fertig, N; Friis, S; Furukawa, H; Hasegawa, Y; Obergrussberger, A; Ohtsuki, A; Oka, T; Stoelzle-Feix, S; Takasuna, K	1
Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y	1
Clausen, C; Cohen, IS; Cui, J; Gao, J; Grinter, SZ; Hou, P; Kang, PW; Liang, H; Lin, Y; Liu, Y; Lu, Z; Ma, Z; Shi, J; Wang, HZ; White, KM; Xu, X; Zhang, G; Zhao, L; Zhao, W; Zou, X	1
Clancy, CE; DeMarco, KR; Harvey, RD; Jeng, MT; Kurokawa, J; López-Redondo, F; Noskov, SY; Perissinotti, LL; Vorobyov, I; Wang, Y; Yang, PC	1
Hamlin, RL; Kijtawornrat, A; Limprasutr, V; Meedech, P; Saengklub, N	1
Bhargava, M; Cho, JH; Chung, MK; Kyriakakis, R; Lindsay, BD; Militello, M; Moore, JC; Niebauer, MJ; Poe, SM; Saliba, WI; Tchou, PJ; Varma, N; Vekstein, C; Wazni, OM; Wilkoff, BL; Wolski, K; Youn, SJ	1
Briceño, DF; Supple, GE	1
Osadchii, OE	3
Beekman, HDM; Belardinelli, L; Bossu, A; de Bakker, JMT; Dunnink, A; Houtman, MJC; Meijborg, VMF; Mollova, N; Rajamani, S; van der Heyden, MAG; Varkevisser, R; Vos, MA	1
Arbel, G; Chorna, SV; Gepstein, A; Gepstein, L; Goldfracht, I; Gruber, A; Huber, I; Setter, N; Shaheen, N; Shinnawi, R; Shiti, A	1
Benson, C; Brown, R; Couderc, JP; Darpo, B; Dota, C; Ferber, G; Ferry, J; Jarugula, V; Keirns, J; Ortemann-Renon, C; Pham, T; Riley, S; Sarapa, N; Ticktin, M; Zareba, W	1
Ababneh, DH; Oakes, DJ; Power, CA; Ritchie, HE; Webster, WS	1
Beekman, HD; de Git, KC; Houtman, MJ; Ijzerman, AP; Linder, T; Stary-Weinzinger, A; Tidwell, RR; van der Heyden, MA; Varkevisser, R; Vos, MA	1
Beekman, HD; Bourgonje, VJ; Oosterhoff, P; Schoenmakers, M; Stams, TR; van der Nagel, R; van Opstal, JM; Vos, MA	1
Csík, N; Farkas, A; Farkas, AS; Farkas, S; Forster, T; Orosz, S; Papp, JG; Sarusi, A; Varró, A	1
Champeroux, P; Fowler, JS; Judé, S; Laigot-Barbé, C; Le Guennec, JY; Maurin, A; Richard, S; Sola, ML; Thireau, J	1
Bányász, T; Hegyi, B; Horváth, B; Kistamás, K; Magyar, J; Nánási, PP; Szentandrássy, N; Váczi, K	1
Fukushima, T; Hata, Y; Hisajima, N; Kano, M; Kinoshita, K; Nishida, N; Tabata, T	1
Cools, F; Danhof, M; Gallacher, DJ; Gotta, V; Morissette, P; Sannajust, F; van Ammel, K; van der Graaf, PH; Visser, SA	1
't Hart, IM; Heitman, LH; IJzerman, AP; Kopf, AH; van Veldhoven, JP; Yu, Z	1
Albert, D; Albert, M; Chohan, J; Garabelli, P; Koomson, E; Parwani, P; Po, S; Reynolds, D; Smith, L; Stavrakis, S; Xie, Q; Xie, R	1
Beekman, JD; Dunnink, A; Heijdel, A; Oosterhoff, P; Stams, TR; van der Heyden, MA; van der Nagel, R; van Rijen, HV; Vos, MA	1
Shenasa, F; Shenasa, M	1
Gold, MR; Leman, RB; Simon, RD; Sturdivant, JL; Wharton, JM	1
Andersson, B; Carlsson, L; Linhardt, G; Löfberg, L	1
Abi-Gerges, N; Crijns, HJ; Heijman, J; Johnson, DM; Pollard, CE; Valentin, JP; Volders, PG	1
Beekman, J; Dunnink, A; Montagne, D; Oosterhoff, P; Sharif, S; van der Heyden, MA; van der Nagel, R; Vos, MA; Winckels, S	1
Csanády, M; Csík, N; Farkas, A; Farkas, AS; Forster, T; Leprán, I; Makra, P; Papp, JG; Rudas, L; Varró, A	1
Ducroq, J; Legrand, JC; Puddu, PE; Rouet, R; Sallé, L	1
Hamlin, RL; Kijtawornrat, A; Sawangkoon, S	1
Antoons, G; Beekman, JD; Bourgonje, VJ; de Windt, LJ; Houtman, MJ; Miedema, LF; Schoenmakers, M; Sipido, K; van der Nagel, R; van Veen, TA; Vos, MA	1
Benites, P; Bozek, J; Kagan, M; Lamoy, M; Onthank, D; Robinson, SP; Yu, M	1
Afshartous, D; Balser, JR; Baudenbacher, FJ; Campbell, CM; Chaigne, S; Days, E; Engers, DW; George, AL; Hopkins, CR; Kupershmidt, S; Lewis, LM; Li, M; Lindsley, CW; Lorinc, AN; Potet, F; Sidorov, VY; Stepanovic, SZ; Venkataraman, R; Weaver, CD; Zou, B	1
Crijns, HJ; Vos, MA	1
Burchardt, H; Hintze, U; Møller, M; Vach, W; Videbaek, J	1
DeBisschop, M; Lower, DL; Martin, LG; Yamreudeewong, W	1
Brendorp, B; Elming, H; Køber, L; Pedersen, OD; Torp-Petersen, C	1
Anyukhovsky, EP; Danilo, P; Gainullin, RZ; Obreztchikova, MN; Plotnikov, A; Robinson, RB; Rosen, MR; Sosunov, EA; Yeom, ZH	1
Pratt, CM	1
Beekman, JD; Bischoff, U; Frederiksen, K; Kall, MA; Matz, J; Spätjens, RL; Stengl, M; Thomsen, MB; Volders, PG; Vos, MA	1
Allen LaPointe, NM; Califf, RM; Chen, A; DeLong, E; Hammill, B; Kramer, JM	1
Chazov, EI; Glushkov, RG; Golitsyn, SP; Iuzhakov, SD; L'vov, AI; Rozenshtraukh, LV; Ruda, MIa	1
Li, WZ	1
Blessing, WW; De Pasquale, CG; Nalivaiko, E	1
Gerlach, U; Nakashima, H; Nattel, S; Schmidt, D	1
Dong, DL; Du, ZM; Li, Z; Song, WH; Wang, HZ; Yang, BF	1
Brendorp, B; Elming, H; Køber, L; Pedersen, OD; Pehrson, S; Torp-Petersen, C	1
Ducouret, P; Ducroq, J; Gérard, JL; Puddu, PE; Rouet, R; Sallé, L; Tabourel, C	1
Bradley, JA; Cass, JD; Chen, X; Dahm, CM; Engwall, MJ; Kadyszewski, E; Sun, Z; Zhou, J	1
Ducouret, P; Ducroq, J; Gérard, JL; Ghadanfar, M; Puddu, PE; Repessé, Y; Rouet, R; Sallé, L	1
Coleman, CI; Guertin, D; Henyan, NN; Kluger, J; McBride, BF; Min, B; Silver, BB; White, CM	1
Attevelt, NJ; Beekman, JD; Chiba, K; Sugiyama, A; Takahara, A; Thomsen, MB; Vos, MA	1
Roukoz, H; Saliba, W	1
Beekman, JD; Maas, JN; Oros, A; Schoenmakers, M; Thomsen, MB; van Opstal, JM; Vos, MA	1
Guo, D; Kowey, PR; Liu, T; Wu, Y; Yan, GX; Zhao, X	1
Grant, AO; Tranquillo, J	1
Brendel, J; Gögelein, H; Linz, DK; Rütten, H; Steinmeyer, K; Wirth, KJ	1
Chen, J; Eto, K; Hashimoto, K; Ni, C; Xue, Y	1
Møller, M	1
Bharucha, D; Kowey, PR; Marinchak, RA; Rials, SJ	1
Brown, AM; Dennis, A; Rampe, D; Roy, ML	1
Sager, PT	2
Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE	1
Kalus, JS; Mauro, VF	1
Kondo, M; Mashima, S; Tsutsumi, T	1
Hilleman, DE; Lenz, TL	1
Doshi, SK; Singh, BN	1
Brendorp, B; Elming, H; Jensen, GB; Jun, L; Køber, L; Malik, M; Torp-Pedersen, C	1
Al-Dashti , R; Sami , M	1
Camm, AJ	1
Anderson, ME; Bonney, S; Mazur, A; Roden, DM	1
De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Somers, K	1
Pham, TV; Rosen, MR	1
Reiffel, JA	1
Khan, IA	1
Allen, MJ; Blackburn, KJ; Butrous, GS; Dalrymple, HW; Rasmussen, HS	1
Honerjäger, P; Schmidt, G	1

Reviews

21 review(s) available for uk 68798 and Arrhythmia

Article	Year
Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity. Computer methods and programs in biomedicine, 2023, Volume: 242 Topics: Arrhythmias, Cardiac; DNA-Binding Proteins; Female; Humans; Male; Potassium; Sulfonamides; Torsades de Pointes	2023
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis. British journal of pharmacology, 2015, Volume: 172, Issue:17 Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sotalol; Sulfonamides; Telemetry; Translational Research, Biomedical	2015
Dofetilide: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias. Cardiac electrophysiology clinics, 2016, Volume: 8, Issue:2 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Phenethylamines; Sulfonamides	2016
Myocardial repolarization and drugs. Impossibility to predict the dominance of anti-arrhythmic over pro-arrhythmic effects of drugs due to differential and ventricular electrical remodeling. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2001, Volume: 1, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Disease Models, Animal; Humans; Phenethylamines; Sulfonamides; Tachycardia, Ventricular; Torsades de Pointes	2001
Potentially significant drug interactions of class III antiarrhythmic drugs. Drug safety, 2003, Volume: 26, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Drug Interactions; Humans; Phenethylamines; Sotalol; Sulfonamides	2003
Dofetilide: a new drug to control cardiac arrhythmia. Expert opinion on pharmacotherapy, 2003, Volume: 4, Issue:6 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Clinical Trials as Topic; Humans; Phenethylamines; Practice Guidelines as Topic; Product Surveillance, Postmarketing; Sulfonamides; Tachycardia, Supraventricular	2003
Pure class III agents for prevention of sudden cardiac death. Journal of cardiovascular electrophysiology, 2003, Volume: 14, Issue:9 Suppl Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Comorbidity; Death, Sudden, Cardiac; Europe; Humans; Hydantoins; Imidazoles; Imidazolidines; Middle Aged; Myocardial Infarction; Phenethylamines; Piperazines; Randomized Controlled Trials as Topic; Sotalol; Sulfonamides; Survival Analysis; Treatment Outcome	2003
A benefit-risk assessment of class III antiarrhythmic agents. Expert opinion on drug safety, 2004, Volume: 3, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Combined Modality Therapy; Defibrillators, Implantable; Dronedarone; Heart Conduction System; Humans; Hydantoins; Imidazolidines; Ion Transport; Life Tables; Membrane Potentials; Meta-Analysis as Topic; Phenethylamines; Piperazines; Risk Assessment; Sotalol; Sulfonamides; Survival Analysis; Torsades de Pointes; Treatment Outcome	2004
Dofetilide: a new class III antiarrhythmic agent. Expert review of cardiovascular therapy, 2007, Volume: 5, Issue:1 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiologic Techniques, Cardiac; Heart Failure; Humans; Phenethylamines; Randomized Controlled Trials as Topic; Sulfonamides; Tachycardia, Supraventricular; Torsades de Pointes; Ventricular Function, Left	2007
Pharmacologic and pharmacokinetic profile of class III antiarrhythmic drugs. The American journal of cardiology, 1997, Oct-23, Volume: 80, Issue:8A Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Humans; Phenethylamines; Sotalol; Sulfonamides	1997
New advances in class III antiarrhythmic drug therapy. Current opinion in cardiology, 1999, Volume: 14, Issue:1 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Denmark; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Postoperative Complications; Potassium Channel Blockers; Randomized Controlled Trials as Topic; Sulfonamides	1999
New advances in class III antiarrhythmic drug therapy. Current opinion in cardiology, 2000, Volume: 15, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides	2000
Dofetilide: a class III-specific antiarrhythmic agent. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:1 Topics: Adult; Aged; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Phenethylamines; Sulfonamides	2000
Dofetilide, a new class III antiarrhythmic agent. Pharmacotherapy, 2000, Volume: 20, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Phenethylamines; Sulfonamides	2000
Pure class III antiarrhythmic drugs: focus on dofetilide. Journal of cardiovascular pharmacology and therapeutics, 2000, Volume: 5, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Electrophysiology; Heart Failure; Humans; Phenethylamines; Sulfonamides	2000
Dofetilide: a new class III antiarrhythmic agent. The Canadian journal of cardiology, 2001, Volume: 17, Issue:1 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Phenethylamines; Potassium Channel Blockers; Sulfonamides	2001
Clinical differences between the newer antiarrhythmic agents. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2000, Volume: 1 Suppl C Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dronedarone; Heart Conduction System; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sulfonamides	2000
Sex, hormones, and repolarization. Cardiovascular research, 2002, Feb-15, Volume: 53, Issue:3 Topics: Aging; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Female; Gonadal Steroid Hormones; Humans; Ion Channels; Long QT Syndrome; Male; Myocardium; Phenethylamines; Potassium Channel Blockers; Rabbits; Receptors, Androgen; Receptors, Estrogen; Sex; Sulfonamides	2002
Transient atrial mechanical dysfunction (stunning) after cardioversion of atrial fibrillation and flutter. American heart journal, 2002, Volume: 144, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Appendage; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Dogs; Electric Countershock; Heart Atria; Humans; Myocardial Contraction; Myocardial Stunning; Phenethylamines; Regional Blood Flow; Sotalol; Sulfonamides; Ultrasonography; Verapamil	2002
Dofetilide, a novel class III antiarrhythmic agent. Journal of cardiovascular pharmacology, 1992, Volume: 20 Suppl 2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Heart; Humans; Phenethylamines; Sulfonamides	1992
[New anti-arrhythmia agents]. Zeitschrift fur Kardiologie, 1992, Volume: 81 Suppl 4 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Humans; Phenethylamines; Procainamide; Propanolamines; Sotalol; Sulfonamides; Survival Rate; Tachycardia	1992

Trials

5 trial(s) available for uk 68798 and Arrhythmia

Article	Year
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study. Journal of clinical pharmacology, 2020, Volume: 60, Issue:1 Topics: Arrhythmias, Cardiac; Biomarkers; Cetirizine; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Conduction System; Heart Rate; Humans; Indoles; Ion Channels; Long QT Syndrome; Male; Moxifloxacin; Ondansetron; Phenethylamines; Quinine; Quinolizines; Risk Assessment; Sulfonamides	2020
The effect of dofetilide on ventricular defibrillation thresholds. Pacing and clinical electrophysiology : PACE, 2009, Volume: 32, Issue:1 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Combined Modality Therapy; Electric Countershock; Female; Humans; Male; Middle Aged; Phenethylamines; Sulfonamides; Treatment Outcome; Ventricular Dysfunction	2009
An evaluation of the impact of oral magnesium lactate on the corrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2006, Volume: 11, Issue:2 Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Humans; Lactic Acid; Magnesium Compounds; Male; Phenethylamines; Recurrence; Sotalol; Statistics, Nonparametric; Sulfonamides; Treatment Outcome	2006
DIAMOND antiarrhythmic trials. Danish Investigations of Arrhythmia and Mortality on Dofetilide. Lancet (London, England), 1996, Dec-07, Volume: 348, Issue:9041 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Denmark; Heart Failure; Humans; Myocardial Infarction; Patient Selection; Phenethylamines; Risk; Sulfonamides	1996
Pause-dependent polymorphic ventricular tachycardia during long-term treatment with dofetilide: a placebo-controlled, implantable cardioverter-defibrillator-based evaluation. Journal of the American College of Cardiology, 2001, Mar-15, Volume: 37, Issue:4 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Defibrillators, Implantable; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Phenethylamines; Sulfonamides; Tachycardia, Ventricular; Torsades de Pointes	2001

Other Studies

65 other study(ies) available for uk 68798 and Arrhythmia

Article	Year
4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: novel antiarrhythmic agents. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepines; Cats; Disease Models, Animal; Dogs; Guinea Pigs; Heart Ventricles; Male; Myocardial Contraction; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Sodium Channels; Structure-Activity Relationship	1993
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
"Third Time's a Charm": Three Times Per Day Dosing of Dofetilide May Be Beneficial in Refractory Atrial Arrhythmias. The American journal of cardiology, 2022, 08-01, Volume: 176 Topics: Arrhythmias, Cardiac; Humans; Phenethylamines; Sulfonamides	2022
Chronically altered ventricular activation causes pro-arrhythmic cardiac electrical remodelling in the chronic AV block dog model. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023, 02-16, Volume: 25, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Atrial Remodeling; Atrioventricular Block; Cardiac Resynchronization Therapy; DNA-Binding Proteins; Dogs; Heart	2023
In silico analysis of the dynamic regulation of cardiac electrophysiology by K The Journal of physiology, 2023, Volume: 601, Issue:13 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiologic Techniques, Cardiac; Ether-A-Go-Go Potassium Channels; Humans; Hypokalemia; Ion Channels; Myocytes, Cardiac	2023
Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil. Heart rhythm, 2020, Volume: 17, Issue:3 Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Heart Ventricles; Humans; Male; Phenethylamines; Potassium Channel Blockers; Quinidine; Ranolazine; Risk Assessment; Sodium Channel Blockers; Sulfonamides; Treatment Outcome	2020
Increased Smooth Muscle Kv11.1 Channel Expression in Pulmonary Hypertension and Protective Role of Kv11.1 Channel Blocker Dofetilide. The American journal of pathology, 2020, Volume: 190, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Animals; Arrhythmias, Cardiac; Case-Control Studies; ERG1 Potassium Channel; Female; Follow-Up Studies; Humans; Male; Muscle, Smooth, Vascular; Phenethylamines; Potassium Channel Blockers; Prognosis; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Sulfonamides; Vascular Remodeling	2020
Dofetilide-Induced Microvolt T-Wave Alternans. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2019, Volume: 2019 Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Phenethylamines; Sulfonamides	2019
A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm. Circulation research, 2020, 04-10, Volume: 126, Issue:8 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotoxicity; Cardiotoxins; Computer Simulation; Drug Discovery; ERG1 Potassium Channel; Female; Humans; Long QT Syndrome; Machine Learning; Male; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Protein Structure, Secondary; Sulfonamides; Topoisomerase II Inhibitors	2020
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment. Journal of pharmacological and toxicological methods, 2020, Volume: 105 Topics: Animals; Arrhythmias, Cardiac; Astemizole; Benchmarking; Calibration; Cardiovascular Agents; Cell Line; CHO Cells; Cricetulus; Drug Discovery; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Heart; HEK293 Cells; Humans; Patch-Clamp Techniques; Phenethylamines; Polypropylenes; Polytetrafluoroethylene; Reference Standards; Reproducibility of Results; Sulfonamides; Terfenadine	2020
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array. SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil	2021
Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects. Proceedings of the National Academy of Sciences of the United States of America, 2021, 05-18, Volume: 118, Issue:20 Topics: Action Potentials; Amino Acid Substitution; Animals; Arrhythmias, Cardiac; Calcium; Dogs; Furans; Gene Expression; Guinea Pigs; Heart Atria; Heart Ventricles; Humans; KCNQ1 Potassium Channel; Moxifloxacin; Myocytes, Cardiac; Oocytes; Patch-Clamp Techniques; Phenethylamines; Potassium; Primary Cell Culture; Pyridines; Pyrimidines; Small Molecule Libraries; Sodium; Sulfonamides; Transgenes; Xenopus laevis	2021
A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. The Journal of physiology, 2017, 07-15, Volume: 595, Issue:14 Topics: Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Arousal; Arrhythmias, Cardiac; Estradiol; Ether-A-Go-Go Potassium Channels; Female; Guinea Pigs; Isoproterenol; Male; Models, Biological; Molecular Docking Simulation; Myocytes, Cardiac; Phenethylamines; Sex Characteristics; Sulfonamides	2017
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes. The Journal of toxicological sciences, 2017, Volume: 42, Issue:5 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cromakalim; Disease Models, Animal; Electrocardiography; Isoflurane; Long QT Syndrome; Phenethylamines; Pinacidil; Quinidine; Rabbits; Risk; Sulfonamides; Systole; Torsades de Pointes; Ventricular Pressure	2017
Safety of Oral Dofetilide Reloading for Treatment of Atrial Arrhythmias. Circulation. Arrhythmia and electrophysiology, 2017, Volume: 10, Issue:10 Topics: Administration, Oral; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Administration Schedule; Drug Dosage Calculations; Electrocardiography, Ambulatory; Female; Heart Atria; Heart Rate; Humans; Male; Medical Records; Middle Aged; Patient Admission; Phenethylamines; Predictive Value of Tests; Retrospective Studies; Risk Factors; Sulfonamides; Time Factors; Torsades de Pointes; Treatment Outcome	2017
Dofetilide Reloaded: To Admit or Not to Admit, That is the Question. Circulation. Arrhythmia and electrophysiology, 2017, Volume: 10, Issue:10 Topics: Arrhythmias, Cardiac; Humans; Phenethylamines; Sulfonamides	2017
Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals. PloS one, 2018, Volume: 13, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiological Phenomena; Female; Flecainide; Guinea Pigs; In Vitro Techniques; Perfusion; Phenethylamines; Procainamide; Quinidine; Sulfonamides	2018
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia. British journal of pharmacology, 2018, Volume: 175, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Myocytes, Cardiac; Phenethylamines; Pyridines; Sulfonamides; Torsades de Pointes; Triazoles	2018
Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies. Stem cell reports, 2018, 06-05, Volume: 10, Issue:6 Topics: Action Potentials; Arrhythmias, Cardiac; Biomarkers; Gene Expression; Humans; Induced Pluripotent Stem Cells; Models, Biological; Molecular Imaging; Myocytes, Cardiac; Phenethylamines; Sulfonamides	2018
Effects of antiarrhythmics on the electrical restitution in perfused guinea-pig heart are critically determined by the applied cardiac pacing protocol. Experimental physiology, 2019, Volume: 104, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Electrocardiography; Female; Guinea Pigs; Heart; Heart Conduction System; Heart Ventricles; Phenethylamines; Quinidine; Refractory Period, Electrophysiological; Sulfonamides; Ventricular Fibrillation	2019
The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo. Birth defects research. Part B, Developmental and reproductive toxicology, 2013, Volume: 98, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Heart; Hypoxia; Limb Deformities, Congenital; Nitroimidazoles; Phenethylamines; Rats; Rats, Sprague-Dawley; Sulfonamides; Teratogens	2013
Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue. British journal of pharmacology, 2013, Volume: 169, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Antiprotozoal Agents; Arrhythmias, Cardiac; Cell Membrane; Dogs; Endocytosis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Kinetics; Membrane Transport Modulators; Mice; Molecular Dynamics Simulation; Pentamidine; Phenethylamines; Potassium Channel Blockers; Recombinant Proteins; Shab Potassium Channels; Structure-Activity Relationship; Sulfonamides	2013
The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs. British journal of pharmacology, 2014, Volume: 171, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Remodeling; Atrioventricular Block; Databases, Factual; Delayed Rectifier Potassium Channels; Disease Models, Animal; Disease Susceptibility; Dogs; Early Diagnosis; Electrocardiography; Female; Heart; Heart Rate; Male; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sulfonamides; Torsades de Pointes	2014
Impaired epicardial activation-repolarization coupling contributes to the proarrhythmic effects of hypokalaemia and dofetilide in guinea pig ventricles. Acta physiologica (Oxford, England), 2014, Volume: 211, Issue:1 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Female; Guinea Pigs; Heart Conduction System; Heart Ventricles; Hypokalemia; Myocardial Contraction; Phenethylamines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides	2014
Assessment of efficacy of proarrhythmia biomarkers in isolated rabbit hearts with attenuated repolarization reserve. Journal of cardiovascular pharmacology, 2014, Volume: 64, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Biomarkers; Chromans; Dose-Response Relationship, Drug; Electrocardiography; Female; Phenethylamines; Rabbits; Sulfonamides; Torsades de Pointes	2014
Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations. British journal of pharmacology, 2015, Volume: 172, Issue:11 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Dogs; Electrophysiological Phenomena; Ganglionic Blockers; Heart Ventricles; Hexamethonium; Macaca fascicularis; Myocytes, Cardiac; Phenethylamines; Sulfonamides; Torsades de Pointes	2015
Cytosolic calcium changes affect the incidence of early afterdepolarizations in canine ventricular myocytes. Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:7 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channel Agonists; Calcium Chelating Agents; Cells, Cultured; Cytosol; Dogs; Egtazic Acid; Female; Heart Ventricles; Male; Myocytes, Cardiac; Phenethylamines; Sulfonamides; Time Factors; Veratridine	2015
The Susceptibilities of Human Ether-à-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:5 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Ether-A-Go-Go Potassium Channels; Genotype; Heart; Heart Conduction System; HEK293 Cells; Humans; Hypokalemia; Ion Channel Gating; Kinetics; Long QT Syndrome; Mutation; Patch-Clamp Techniques; Phenethylamines; Phenotype; Potassium; Potassium Channel Blockers; Sulfonamides	2015
Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel. European journal of medicinal chemistry, 2015, Dec-01, Volume: 106 Topics: Acetamides; Allosteric Regulation; Arrhythmias, Cardiac; Cells, Cultured; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Kinetics; Molecular Structure; Naphthyridines; Phenethylamines; Potassium Channel Blockers; Pyridines; Structure-Activity Relationship; Sulfonamides	2015
Comparison of QT Interval Readings in Normal Sinus Rhythm Between a Smartphone Heart Monitor and a 12-Lead ECG for Healthy Volunteers and Inpatients Receiving Sotalol or Dofetilide. Journal of cardiovascular electrophysiology, 2016, Volume: 27, Issue:7 Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Case-Control Studies; Electrocardiography; Female; Healthy Volunteers; Heart Rate; Humans; Inpatients; Male; Middle Aged; Mobile Applications; Phenethylamines; Predictive Value of Tests; Reproducibility of Results; Smartphone; Sotalol; Sulfonamides	2016
Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs. Circulation journal : official journal of the Japanese Circulation Society, 2016, May-25, Volume: 80, Issue:6 Topics: Action Potentials; Anesthesia; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Dogs; Phenethylamines; Risk; Streptomycin; Sulfonamides; Torsades de Pointes	2016
Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo. Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Long QT Syndrome; Male; Methoxamine; Phenethylamines; Potassium Channel Blockers; Rabbits; Sulfonamides; Time Factors	2009
I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation. Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:1 Topics: Action Potentials; Aniline Compounds; Animals; Arrhythmias, Cardiac; Calcium; Cells, Cultured; Dogs; Egtazic Acid; Female; Heart Ventricles; Ion Channels; Isoproterenol; Myocytes, Cardiac; Phenethylamines; Phenyl Ethers; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Adrenergic, beta; Sodium; Sodium-Calcium Exchanger; Sulfonamides	2010
Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model. Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:6 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Dogs; Female; Halothane; Heart Block; Isoflurane; Male; Phenethylamines; Sulfonamides; Thiopental; Torsades de Pointes	2010
Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in α(1) -adrenoceptor-stimulated, anaesthetized rabbits. British journal of pharmacology, 2010, Volume: 161, Issue:7 Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Baroreflex; Biomarkers; Electrocardiography; Female; Heart; Phenethylamines; Phenylephrine; Rabbits; Receptors, Adrenergic, alpha-1; Sulfonamides; Torsades de Pointes	2010
I(Kr) vs. I(Ks) blockade and arrhythmogenicity in normoxic rabbit Purkinje fibers: does it really make a difference? Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Delayed Rectifier Potassium Channels; Epinephrine; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Purkinje Fibers; Rabbits; Sotalol; Sulfonamides	2011
Assessment of QT-prolonging drugs in the isolated normal and failing rabbit hearts. The Journal of toxicological sciences, 2012, Volume: 37, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Cisapride; Electrocardiography; Feasibility Studies; Glucose; Heart; Heart Failure; In Vitro Techniques; Male; Models, Animal; Phenethylamines; Quinidine; Rabbits; Sulfonamides; Torsades de Pointes; Tromethamine	2012
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart rhythm, 2012, Volume: 9, Issue:11 Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Benzylamines; Calcineurin; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomyopathy, Hypertrophic; Cyclosporine; Disease Models, Animal; Dogs; Isoproterenol; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Phenotype; Phosphorylation; Random Allocation; Sulfonamides; Ventricular Remodeling	2012
LMI1195 PET imaging in evaluation of regional cardiac sympathetic denervation and its potential role in antiarrhythmic drug treatment. European journal of nuclear medicine and molecular imaging, 2012, Volume: 39, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nerve Block; Cell Line, Tumor; Fluorobenzenes; Guanidines; Heart; Heart Rate; Heart Ventricles; Humans; Phenethylamines; Phenol; Positron-Emission Tomography; Rabbits; Radiopharmaceuticals; Sulfonamides	2012
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. The Journal of biological chemistry, 2012, Nov-16, Volume: 287, Issue:47 Topics: Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Discovery; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Muscle Proteins; Myocardium; Naphthyridines; Phenethylamines; Potassium Channel Blockers; Pyridines; Rabbits; Structure-Activity Relationship; Sulfonamides	2012
QT interval dynamics predict mortality in high-risk patients after myocardial infarction. Scandinavian cardiovascular journal : SCJ, 2002, Volume: 36, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Rate; Humans; Male; Multivariate Analysis; Myocardial Infarction; Observer Variation; Phenethylamines; Predictive Value of Tests; Prospective Studies; Risk Factors; Sulfonamides; Survival Analysis; Treatment Outcome; Ventricular Dysfunction, Left	2002
Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia. Cardiovascular research, 2003, Aug-01, Volume: 59, Issue:2 Topics: Action Potentials; Aging; Animals; Animals, Newborn; Arrhythmias, Cardiac; Dogs; Female; Male; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Sulfonamides	2003
Electrophysiological safety of sertindole in dogs with normal and remodeled hearts. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2 Topics: Action Potentials; Animals; Antipsychotic Agents; Arrhythmias, Cardiac; Dogs; Electrophysiology; Heart; Imidazoles; Indoles; Myocytes, Cardiac; Phenethylamines; Sulfonamides	2003
Evaluation of the dofetilide risk-management program. American heart journal, 2003, Volume: 146, Issue:5 Topics: Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Electrocardiography; Female; Guideline Adherence; Humans; Incidence; Male; Middle Aged; North Carolina; Phenethylamines; Practice Guidelines as Topic; Product Labeling; Program Evaluation; Risk Management; Sotalol; Sulfonamides; Torsades de Pointes	2003
[Development of original Russian antiarrhythmic drugs of the 3rd class]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:12 Topics: Adolescent; Adult; Aged; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzamides; Clinical Trials as Topic; Dogs; Electrocardiography; Female; Humans; Male; Middle Aged; Phenethylamines; Potassium Channel Blockers; Purkinje Fibers; Rabbits; Russia; Sulfonamides; Time Factors	2003
[Progress in the clinical use of anti-arrhythmic drugs (I)]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Child; Clinical Trials as Topic; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sulfonamides	2003
Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide. Basic research in cardiology, 2004, Volume: 99, Issue:2 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arousal; Arrhythmias, Cardiac; Electrocardiography; Formaldehyde; Heart; Heart Ventricles; Isoproterenol; Motion; Pain; Phenethylamines; Physical Stimulation; Premedication; Propranolol; Rabbits; Stimulation, Chemical; Sulfonamides	2004
In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions. Cardiovascular research, 2004, Mar-01, Volume: 61, Issue:4 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Chromans; Dogs; Electrocardiography; Electrophysiology; Female; Male; Myocardium; Nadolol; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Sulfonamides	2004
Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels. Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Delayed Rectifier Potassium Channels; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Hydantoins; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Myocardial Ischemia; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quinidine; Sulfonamides; Transfection; Xenopus	2004
Electrophysiological effects of azimilide in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Ventricles; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenethylamines; Piperazines; Potassium Channel Blockers; Sulfonamides; Time Factors	2005
QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome. British journal of pharmacology, 2005, Volume: 146, Issue:6 Topics: Action Potentials; Animals; Anti-Infective Agents; Area Under Curve; Arrhythmias, Cardiac; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channels, Inwardly Rectifying; Quinolines; Rabbits; Sulfonamides; Telemetry; Treatment Outcome	2005
Class III effects of dofetilide and arrhythmias are modulated by [K+]o in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. European journal of pharmacology, 2006, Feb-27, Volume: 532, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Ventricles; Hyperkalemia; In Vitro Techniques; Kinetics; Models, Animal; Myocardial Reperfusion Injury; Myocardium; Phenethylamines; Potassium; Potassium Channel Blockers; Sulfonamides	2006
No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. British journal of pharmacology, 2006, Volume: 149, Issue:8 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Arrhythmias, Cardiac; Aza Compounds; Azithromycin; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Electrophysiology; Fluoroquinolones; Heart Block; Heart Rate; Long QT Syndrome; Moxifloxacin; Phenethylamines; Quinolines; Sulfonamides; Torsades de Pointes	2006
Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovascular research, 2007, Feb-01, Volume: 73, Issue:3 Topics: Action Potentials; Acute Disease; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Electrocardiography; Female; Heart Block; Heart Conduction System; Heart Rate; Male; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Torsades de Pointes; Ventricular Remodeling	2007
L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Guinea Pigs; Hydantoins; Imidazolidines; In Vitro Techniques; Myocytes, Cardiac; Nicardipine; Patch-Clamp Techniques; Phenethylamines; Piperazines; Rabbits; Sulfonamides	2007
Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation. Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Guinea Pigs; Hydantoins; Imidazolidines; Myocytes, Cardiac; Nicardipine; Patch-Clamp Techniques; Phenethylamines; Piperazines; Rabbits; Sulfonamides; Torsades de Pointes	2007
In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231. Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:4 Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Function; Blood Flow Velocity; Carbachol; Cardiotonic Agents; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Female; Goats; Guinea Pigs; Heart Atria; Heart Ventricles; Humans; Inhibitory Concentration 50; Ion Channels; Male; Myocytes, Cardiac; Papillary Muscles; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides; Swine; Time Factors	2007
Effects of dofetilide, a class III antiarrhythmic drug, on various ventricular arrhythmias in dogs. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Digitalis; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Epinephrine; Female; Male; Myocardial Infarction; Myocardial Reperfusion; Phenethylamines; Plants, Medicinal; Plants, Toxic; Sulfonamides; Tachycardia, Ventricular; Ventricular Fibrillation	1996
A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS letters, 1997, Nov-03, Volume: 417, Issue:1 Topics: Arrhythmias, Cardiac; Cation Transport Proteins; Cell Line; Cisapride; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart; Humans; Kv1.5 Potassium Channel; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tumor Cells, Cultured	1997
Dofetilide. UK 68, UK 68798, Tikosyn, Xelide. Drugs in R&D, 1999, Volume: 1, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drugs, Investigational; Guinea Pigs; Humans; In Vitro Techniques; Phenethylamines; Potassium Channel Blockers; Sulfonamides	1999
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 223, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Female; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Male; Methoxamine; Phenethylamines; Piperazines; Procainamide; Quaternary Ammonium Compounds; Rabbits; Sotalol; Sulfonamides	2000
Potassium channel openers antagonize the effects of class III antiarrhythmic agents in canine Purkinje fiber action potentials. Implications for prevention of proarrhythmia induced by class III agents. Japanese heart journal, 1999, Volume: 40, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Purkinje Fibers; Pyridines; Sulfonamides	1999
Qt dispersion has no prognostic information for patients with advanced congestive heart failure and reduced left ventricular systolic function. Circulation, 2001, Feb-13, Volume: 103, Issue:6 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Denmark; Double-Blind Method; Electrocardiography; Follow-Up Studies; Heart Failure; Humans; Middle Aged; Observer Variation; Phenethylamines; Prognosis; Sulfonamides; Survival Analysis; Ventricular Dysfunction, Left	2001
Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model. Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:5 Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Electrocardiography; Female; Heart Rate; Incidence; Long QT Syndrome; Male; Methoxamine; Models, Cardiovascular; Phenethylamines; Rabbits; Receptors, Adrenergic, alpha-1; Risk Factors; Sex Factors; Sulfonamides; Treatment Outcome; Women's Health	2001
Is it rational, reasonable or excessive, and consistently applied? One view of the increasing FDA emphasis on safety first for the release and use of antiarrhythmic drugs for supraventricular arrhythmias. Journal of cardiovascular pharmacology and therapeutics, 2001, Volume: 6, Issue:4 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Approval; Drugs, Generic; Heart Ventricles; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides; United States; United States Food and Drug Administration	2001