ubiquinone and Virus-Diseases

In this review, the author shows that simultaneous multiple disorders caused by reactivation of Epstein-Barr virus can lead to salivary gland disorders as part of Sjogren's syndrome (SS). Therefore, clinicians must differentiate SS from other diseases when diagnosing and treating salivary gland disorders. In particular, the author explains how microbial infection in SS overcomes immunological tolerance, leading to pathological changes, and how cytokine overexpression and endocrine disrupters contribute to glandular tissue injury. Also, the author suggests that involvement of reactive oxygen species is a common pathogenesis of salivary gland disorders and SS, so regulation of oxidative stress is an effective treatment for both. The results of clinical studies on restoring salivary gland function and regenerating salivary glands with tissue stem cells may provide clues on elucidating the cause of SS.

Topics: Antioxidants; Arthritis, Rheumatoid; Autoantigens; Autoimmune Diseases; Cytokines; Diagnosis, Differential; Dioxins; Epstein-Barr Virus Infections; Estrogens; Female; Genetic Predisposition to Disease; Herpesvirus 4, Human; Humans; Interleukin-10; Lymphocytes; Male; Mikulicz' Disease; Oxidative Stress; Reactive Oxygen Species; Salivary Glands; Sjogren's Syndrome; Stem Cell Transplantation; Ubiquinone; Virus Activation; Virus Diseases

Tissue resident memory CD8

Topics: Animals; CD8-Positive T-Lymphocytes; Cell Respiration; Cholesterol; Humans; Immunologic Memory; Intestine, Small; Lymphocytes, Tumor-Infiltrating; Metabolomics; Mevalonic Acid; Mice; Mitochondria; Neoplasms; Ubiquinone; Virus Diseases; Viruses