ubiquinone has been researched along with Uremia* in 3 studies
1 trial(s) available for ubiquinone and Uremia
| Article | Year |
|---|---|
Serum coenzyme Q10 in uremic patients on chronic hemodialysis.
In a group of 48 chronic hemodialysis patients, serum levels of coenzyme Q10 (CoQ) have been measured and appeared abnormally low in 62% of cases. Figures were positively correlated to those of serum vitamin E (vit E), although the latter were within a normal range. The chronic hemodialysis (CHD) patients with normal serum values of CoQ exhibited higher blood triglycerides. Pathologically low levels of serum vit E were found only in uremic subjects on conservative regimen with dietary restrictions and low compliance to protein-caloric intake. The reduced CoQ levels may contribute to the defective serum antioxidant activity and the increased peroxidative damage in uremic patients on CHD. Topics: Aged; Cholesterol; Coenzymes; Female; Hemodynamics; Humans; Male; Middle Aged; Reference Values; Triglycerides; Ubiquinone; Uremia; Vitamin E | 1994 |
2 other study(ies) available for ubiquinone and Uremia
| Article | Year |
|---|---|
Plasma levels of coenzyme Q(10), vitamin E and lipids in uremic patients on conservative therapy and hemodialysis treatment: some possible biochemical and clinical implications.
Coenzyme Q(10) (CoQ(10)), vitamin E, total cholesterol, HDL-cholesterol (HDLC) and triglycerides were measured in the plasma of 62 patients with kidney failure, 46 under hemodialysis treatment and 16 under conservative therapy, and 95 controls. The sum of LDL-cholesterol (LDL-C) and VLDL-cholesterol (VLDL-C) was also calculated for each patient. The ratio CoQ(10)/LDL-C+VLDL-C in both conservative therapy and hemodialysis populations was significantly lower (P<0.001) compared with normal controls and remained unchanged after the dialysis treatment. On the contrary the ratio vitamin E/LDL-C+VLDL-C was normal but decreased significantly (P<0.02) after each dialysis. Since coenzyme Q is the main inhibitor of the prooxidant action of vitamin E, it was hypothesized that its decrease in both the populations examined could make the lipoproteins of these patients more vulnerable to a peroxidative attack. Topics: Aged; Case-Control Studies; Cholesterol, LDL; Cholesterol, VLDL; Coenzymes; Creatinine; Humans; Lipid Peroxidation; Lipids; Middle Aged; Renal Dialysis; Ubiquinone; Uremia; Vitamin E | 2000 |
Coenzyme Q10 levels, plasma lipids and peroxidation extent in renal failure and in hemodialytic patients.
Coenzyme Q10 (CoQ10), vitamin E, triglycerides and conjugated dienes were measured in a group of 48 patients on chronic hemodialysis, in 15 uremic patients and in a control group of 10 normal subjects. CoQ10 levels were significantly lower (P < 0.001) in both hemodialytic and uremic patients compared with the normal group whereas triglycerides were significantly higher (P < 0.001) with respect to both normal subjects and uremic patients. Conjugated dienes were significantly higher (P < 0.001) in both hemodialytic and uremic patients with respect to normal subjects. The predialytic values of vitamin E were higher in hemodialytic patients with respect to both normal subjects and uremic patients whereas the postdialytic values were in the normal range. A restoration mechanism of vitamin E after hemodialytic treatment was hypothesized. Topics: Adult; Aged; Coenzymes; Humans; Kidney Failure, Chronic; Lipid Peroxidation; Lipids; Middle Aged; Renal Dialysis; Triglycerides; Ubiquinone; Uremia; Vitamin E | 1994 |