ubiquinone and Periodontitis

Coenzyme Q10 gel might be beneficial for periodontitis. However, the results have been controversial. We designed a systematic review and meta-analysis to explore the efficacy of coenzyme Q10 in periodontitis patients.. A systematic review of controlled trials (PROSPERO: CRD42020212424) was performed from 1980 to August 2020 by 2 separate investigators through the following databases: Embase, CENTRAL, PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and ProQuest. Hand search of reference lists of the included studies was also performed. Of 269 records, eleven trials were included in the meta-analysis using a random-effect model.. Coenzyme Q10 could significantly reduce Plaque Index (SMD, -0.64; CI, -1.03 to -0.26, P = .002; I. Our findings encourage administration of coenzyme Q10 gel in periodontitis based on its meaningful effect on Plaque Index, Bleeding Index, gingival index, clinical attachment level and Pocket Depth. Future studies with better qualities are required for a better conclusion.

Topics: Humans; Periodontitis; Ubiquinone

In recent years, there has been a tremendous expansion in medical and dental research concerned with free radicals, reactive oxygen species, and anti-oxidant defense mechanisms. This review is intended to provide a critical, up-to-date summary of the field, with particular emphasis on its implications for the application of "anti-oxidant therapy" in periodontal disease. We have reviewed the nomenclature, mechanisms of actions, features, and sources of most common free radicals and reactive oxygen species, as well as analyzed the typical biological targets for oxidative damage. Based on a review of direct and indirect anti-oxidant host defenses, particularly in relation to the key role of polymorphonuclear neutrophils in periodontitis, we review current evidence for oxidative damage in chronic inflammatory periodontal disease, and the possible therapeutic effects of anti-oxidants in treating and/or preventing such pathology, with special attention to vitamin E and Co-enzyme Q.

Topics: Antioxidants; Chronic Disease; Free Radicals; Humans; Neutrophils; Oxidative Stress; Periodontitis; Reactive Oxygen Species; Ubiquinone; Vitamin E

Topical application of Coenzyme Q10 (CoQ10) to the periodontal pocket was evaluated with and without subgingival mechanical debridement. Ten male patients with adult periodontitis participated and 30 periodontal pockets were selected. During the first 3 weeks, the patients did not receive any periodontal therapy except the topical application of CoQ10. After the first 3-week period, root planning and subgingival scaling were performed in all sites. CoQ10 was applied in 20 of the pockets once a week for a period of 6 weeks. Soybean oil was applied to the remaining 10 sites as a control. In the first 3-week period, significant reductions in gingival crevicular fluid flow, probing depth and attachment loss were found only at experimental sites. After mechanical subgingival debridement, significant decreases in the plaque index, gingival crevicular fluid flow, probing depth and attachment loss were found both at experimental and control sites. However, significant improvements in the modified gingival index, bleeding on probing and peptidase activity derived from periodontopathic bacteria were observed only at experimental sites. These results suggest that topical application of CoQ10 improves adult periodontitis not only as a sole treatment but also in combination with traditional nonsurgical periodontal therapy.

Topics: Administration, Topical; Adult; Bacteria; Coenzymes; Combined Modality Therapy; Dental Plaque Index; Dental Scaling; Humans; Male; Middle Aged; Periodontal Index; Periodontitis; Pilot Projects; Root Planing; Treatment Outcome; Ubiquinone

Eight patients under routine care for periodontitis received oral treatment with a form of coenzyme Q (7 / CoQ10 and 1 / hexahydrocoenzyme Q4). An unchanged plaque score showed the patients cooperated and were under plaque control. The periodontal score decreased (p less than 0.01) on CoQ treatment. Unexpectedly, the periodontal pocket depth decreased (P less than 0.05) on CoQ treatment since all patients were considered candidates for surgical intervention. Healing was so excellent 5-7 days post-biopsy that the biopsy sites were difficult to locate. The healing was viewed as extraordinarily effective. The mean value of the specific activities of the succinate dehydrogenase-coenzyme Q10 reductase of gingival biopsies increased (P less than 0.05) during treatment which could correlate with the extraordinarily healing. Treatment of periodontitis with coenzyme Q should be considered as adjunctive treatment with current dental practice.

Topics: Adult; Clinical Trials as Topic; Dental Calculus; Dental Plaque; Diet; Erythrocytes; Gingiva; Humans; Middle Aged; Mitochondria; Oxidoreductases; Periodontal Index; Periodontitis; Succinate Dehydrogenase; Ubiquinone

Topics: Adult; Aged; Avitaminosis; Clinical Trials as Topic; Gingival Diseases; Gingival Hyperplasia; Gingivitis; Humans; Male; Middle Aged; Oral Hemorrhage; Pain; Periodontal Diseases; Periodontitis; Placebos; Pruritus; Tooth Mobility; Ubiquinone

Periodontal diseases are worldwide chronic inflammatory conditions that are associated with heavy production of reactive oxygen species followed by damage of the tooth-supporting tissues. Although the mechanical approach of scaling and root planing (SRP) for removing of plaque is considered as the key element for controlling periodontitis, the anatomical complexity of the teeth hinders accessibility to deeper points. The aim of this study was to design a micellar nanocarrier of coenzyme Q10 (Q

Topics: Adult; Antioxidants; Combined Modality Therapy; Dental Scaling; Drug Compounding; Female; Humans; Lipid Peroxidation; Male; Micelles; Middle Aged; Nanoparticles; Periodontitis; Root Planing; Treatment Outcome; Ubiquinone

To investigate the effect of coenzyme Q10 on the levels of tumor necrosis factor-α(TNF-α) and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats.. A total of 48 healthy Wistar rats were divided into 3 groups of 16 randomly, normal group, coenzyme Q10 treatment group (Q10 group) and periodontitis group.Normal group was fed with normal diet and water. Periodontitis models were established in other two groups.Q10 group received coenzyme Q10 for 12 weeks and periodontitis group was fed with the same dose of normal saline.Four rats in each group were sacrified before administration and 4, 8 and 12 weeks after administration. Gingival tissue samples from mandiblar first permanent molar were taken. The levels of TNF-α and IL-10 were detected by immunohistochemistry.. The expression of TNF-α in periodontitis group [54.9% (52.9%, 57.3%)] was significantly higher than that in Q10 group [15.1% (12.7%, 17.5%)] at 12 weeks (P < 0.0167) . The expression of IL-10 in periodontitis group [8.9% (7.9%, 10.0%)]was significantly lower than that in the Q10 group [38.9% (38.0%, 40.4%)] (P < 0.0167) . The expression of TNF-α in periodontitis group was significantly higher than that in Q10 group at 12th weeks (P < 0.0167) . The expression of IL-10 in periodontitis group was significantly lower than that in the Q10 group (P < 0.0167).. Coenzyme Q10 inhibits the expression of TNF-α and promotes the expression of IL-10 in periodontal tissues of experimental periodontitis rats. Coenzyme Q10 may play a role in treating periodontitis.

Topics: Animals; Antioxidants; Gingiva; Interleukin-10; Periodontitis; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ubiquinone

In periodontitis it has been found that some perturbation exists in lipid biomarkers, such as increased serum total cholesterol and low-density lipoprotein cholesterol. Nevertheless, the relationship between fatty acids and periodontitis has been demonstrated only in a few studies and remains controversial. The aim of this investigation was to explore the effects of periodontitis on a cluster of traditional and novel cardiovascular risk factors such as plasma-lipids profile, types of plasma fatty acids, adhesion molecules and systemic inflammatory markers.. At a university dental school, 56 patients all over 35 years old were enrolled and invited to participate in the study. Total plasma fatty acids, saturated, n-6 polyunsaturated and monounsaturated fatty acids, peroxidability index, soluble VCAM, TNF-alpha, cholesterol, triacylglycerols, and VLDL-c were significantly higher in the periodontitis group compared to the non-periodontitis group.. This close association found between plasma triacylglycerols, LDL-c, saturated fatty acids, polyunsaturated fatty acids, total amount of fatty acids and coenzyme Q(10) with some periodontal data such as periodontal probing depth, recession of the gingival margin and clinical attachment level (Pearson correlation between 0.3 and 0.6), leads to the conclusion that there is an inter-relationship between periodontitis, plasma fatty acids profile and the increase in metabolic risk factors for cardiovascular diseases.

Topics: Adult; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cholesterol; Cholesterol, VLDL; Fatty Acids; Female; Humans; Inflammation Mediators; Male; Middle Aged; Periodontitis; Risk Factors; Schools, Dental; Triglycerides; Tumor Necrosis Factor-alpha; Ubiquinone; Up-Regulation; Vascular Cell Adhesion Molecule-1

Topics: Animals; Dogs; Gingiva; Gingivitis; Mitochondria; Periodontitis; Ubiquinone

A 25-year old Caucasian with uniquely severe and chronic periodontal disease, requiring extraction of all teeth, was treated with hexahydrocoenzyme Q4 which functions like naturally occurring coenzyme Q10 in gingival tissue. During the fourth and fifth examinations after the seventh and eighth weeks of treatment, three dentists separately and independently scored clinical improvements of five symptoms by significances of essentially P less than 0.01 to P less than 0.001. The initial benefit of the treatment was observed at the second examination after three weeks of treatment. The administration of coenzyme Q could be an important therapeutic adjunct to periodontal therapy for certain patients.

Topics: Adult; Humans; Male; Periodontitis; Time Factors; Ubiquinone

Topics: Humans; Periodontitis; Ubiquinone