ubiquinone has been researched along with Malaria* in 13 studies
1 review(s) available for ubiquinone and Malaria
Article | Year |
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Antimetabolites of coenzyme Q. Their potential application as antimalarials.
Topics: Animals; Antimalarials; Antimetabolites; Chickens; Electron Transport; Malaria; Naphthoquinones; Plasmodium; Plasmodium malariae; Ubiquinone | 1974 |
1 trial(s) available for ubiquinone and Malaria
11 other study(ies) available for ubiquinone and Malaria
Article | Year |
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Exploring Ubiquinone Biosynthesis Inhibition as a Strategy for Improving Atovaquone Efficacy in Malaria.
Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH Topics: Atovaquone; Humans; Malaria; Mitochondria; Oxidation-Reduction; Ubiquinone | 2021 |
Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.
Atovaquone is a new anti-malarial agent that specifically targets the cytochrome bc1 complex and inhibits parasite respiration. A growing number of failures of this drug in the treatment of malaria have been genetically linked to point mutations in the mitochondrial cytochrome b gene. To better understand the molecular basis of atovaquone resistance in malaria, we introduced five of these mutations, including the most prevalent variant found in Plasmodium falciparum (Y268S), into the cytochrome b gene of the budding yeast Saccharomyces cerevisiae and thus obtained cytochrome bc1 complexes resistant to inhibition by atovaquone. By modeling the variations in cytochrome b structure and atovaquone binding with the mutated bc1 complexes, we obtained the first quantitative explanation for the molecular basis of atovaquone resistance in malaria parasites. Topics: Amino Acid Sequence; Animals; Antimalarials; Atovaquone; Cytochromes b; Dose-Response Relationship, Drug; Electron Transport Complex III; Inhibitory Concentration 50; Kinetics; Malaria; Models, Molecular; Molecular Sequence Data; Mutation; Naphthoquinones; Oxygen Consumption; Plasmodium falciparum; Point Mutation; Protein Binding; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Time Factors; Ubiquinone | 2005 |
[New medicines for malaria].
Topics: Humans; Malaria; Ubiquinone | 1974 |
Antimalarial quinones for prophylaxis based on a rationale of inhibition of electron transfer in Plasmodium.
Knowledge of the biochemistry of Plasmodium is emerging as a new field. Previous studies showed that the parasite apparently requires electron transfer for energy, and techniques to study such energy mechanisms are available. The discovery of the existence of coenzyme Q(8) in Plasmodium implies an indispensable functionality for this redox entity in the electron transfer of the parasite, as coenzyme Q(n) similarily functions in other forms of life. Effective antimalarial activity in prophylaxis has been demonstrated in sporozoite-induced infections by Plasmodium gallinaceum in chicks by several representatives of 7-alkylmercapto-6-hydroxy-5,8-quinolinequinones. The absence of toxicity in this assay even at greatly elevated dosage underscores the achievement of selectivity and safety to the host for the potential utilization of antimetabolites of coenzyme Q(n) as medicinals. Seven new 7-alkylmercapto-6-hydroxy-5,8-quinoline-quinones were synthesized. The structural variations of the 7-alkylmercapto group in relationship to the antimalarial activities reveal substantial differences in biological activities, which can reflect molecular specificities of enzyme sites and which are not evident from the deceptively minor structural differences in the alkylmercapto groups. These analogs of coenzyme Q(8) having effective antimalarial activity are known to inhibit mammalian coenzyme Q(n) enzymes, and could be useful in elucidation of the basic electron transfer mechanisms of Plasmodium. Topics: Animals; Antimalarials; Chickens; Dose-Response Relationship, Drug; Electron Transport; Malaria; Mice; Plasmodium; Plasmodium berghei; Quinolines; Quinones; Sulfhydryl Compounds; Ubiquinone | 1974 |
Antimetabolites of coenzyme Q. 20. Synthesis of new alkyl-5,8-quinoxalinequinones as potential inhibitors of coenzyme Q and as antimalarial drugs.
Topics: Animals; Antimalarials; Antimetabolites; Chickens; In Vitro Techniques; Malaria; Mice; Mitochondria; NADH, NADPH Oxidoreductases; Plasmodium berghei; Quinones; Quinoxalines; Succinate Dehydrogenase; Ubiquinone | 1973 |
Antimetabolites of coenzyme Q. 16. New alkylmercaptoquinones having antimalarial curative activity.
Topics: Animals; Antimalarials; Antimetabolites; Cattle; Chickens; Malaria; Mice; Mitochondria; NAD; Plasmodium berghei; Quinones; Succinate Dehydrogenase; Sulfides; Ubiquinone | 1973 |
Nonlinear response of the reticuloendothelial system upon stimulation.
Topics: Animals; Avian Sarcoma Viruses; Bacterial Infections; Chickens; Chloroquine; Dose-Response Relationship, Drug; Escherichia coli; Fatty Acids; Female; Friend murine leukemia virus; Lipids; Lipopolysaccharides; Liver Extracts; Malaria; Male; Mice; Mononuclear Phagocyte System; Neoplasms, Experimental; Polysaccharides, Bacterial; Pseudomonas aeruginosa; Salmonella typhimurium; Sharks; Shock, Septic; Stimulation, Chemical; Ubiquinone | 1972 |
Synthesis of new alkylamino- and alkylaminomethyl-5,8-quinolinequinones as inhibitors of coenzyme Q and as antimalarials.
Topics: Alkylation; Animals; Antimalarials; Culicidae; Malaria; Mice; NAD; Oxidoreductases; Quinolines; Quinones; Succinate Dehydrogenase; Ubiquinone | 1972 |
Synthesis of new 2-alkylamino-1,4-naphthoquinones as inhibitors of coenzyme Q and as antimalarials.
Topics: Animals; Antimalarials; Malaria; Mice; Microbial Sensitivity Tests; Mitochondria; Naphthoquinones; Plasmodium; Ubiquinone | 1972 |
Biosynthesis of ubiquinones by malarial parasites. I. Isolation of [14C]ubiquinones from cultures of rhesus monkey blood infected with Plasmodium knowlesi.
Topics: Animals; Benzoates; Blood; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Culture Techniques; Erythrocytes; Haplorhini; Malaria; Plasmodium; Ubiquinone | 1969 |
Occurrence of ubiquinones-8 and -9 in Plasmodium lophurae.
Topics: Animals; Chromatography, Paper; Chromatography, Thin Layer; Ducks; Malaria; Plasmodium; Spectrum Analysis; Ubiquinone; Vitamin K | 1967 |