ubiquinone and Lymphoma

Adriamycin (ADR), one of the anthracycline derivatives, has the most strong cardiotoxicity. We studied the cardiotoxicity caused by ADR in New Zealand white rabbits and its protection by the medication of CoQ10. The findings of ECG and the myocardial tissue examined by the electron microscope showed the effectiveness of the injection of CoQ10 to prevent the cardiotoxicity caused by ADR. The concomitant injection of CoQ10 dissolved in saline was tried in patients with various kinds of neoplasm who were given more than 200 mg of ADR or DM. Only one patient showed the ST-T change. On the contrary, 3 of patients given more than 200 mg ADR or DM alone showed abnormal change of ECG.

Topics: Acute Disease; Adult; Aged; Animals; Arrhythmias, Cardiac; Cardiomyopathies; Coenzymes; Doxorubicin; Electrocardiography; Female; Heart; Humans; Leukemia; Lymphoma; Male; Middle Aged; Rabbits; Ubiquinone

Cardiotoxicity induced by adriamycin and protective effect by coenzyme Q10 were studied in 80 closely-followed patients receiving chemotherapy with adriamycin. Serial electrocardiograms were recorded immediately before and after the administration of adriamycin each times. The electrocardiographic parameters (heart rate, P-Q duration, QRS-duration, QRS voltage and QTc-duration) were analyzed. In patients treated with adriamycin alone, QTc-duration was prolonged significantly. On the other hand, in patients treated with adriamycin plus coenzyme Q10, QTc-duration was not significantly prolonged. This Suggests that coenzyme Q10 may reduce negative inotropic action induced by adriamycin. Further, the QRS voltage was also significantly decreased in patients treated with adriamycin alone, but was not decreased in patients treated with adriamycin plus coenzyme Q10. These findings suggest that some electrocardiographic changes due to adriamycin may be prevented by coenzyme Q10.

Topics: Coenzymes; Doxorubicin; Electrocardiography; Female; Gastrointestinal Neoplasms; Heart; Heart Rate; Humans; Leukemia; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Time Factors; Ubiquinone

Topics: Anemia, Hypochromic; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Buffers; Catalase; Chlorides; Cobalt; Fever; Hepatitis A; Histocytochemistry; Humans; Hydroquinones; Leukocytes; Lymphadenitis; Lymphoma; Male; Microscopy, Phase-Contrast; Nephrotic Syndrome; Prostatitis; Staining and Labeling; Toxoplasmosis; Ubiquinone