ubiquinone and Dental-Plaque

Eight patients under routine care for periodontitis received oral treatment with a form of coenzyme Q (7 / CoQ10 and 1 / hexahydrocoenzyme Q4). An unchanged plaque score showed the patients cooperated and were under plaque control. The periodontal score decreased (p less than 0.01) on CoQ treatment. Unexpectedly, the periodontal pocket depth decreased (P less than 0.05) on CoQ treatment since all patients were considered candidates for surgical intervention. Healing was so excellent 5-7 days post-biopsy that the biopsy sites were difficult to locate. The healing was viewed as extraordinarily effective. The mean value of the specific activities of the succinate dehydrogenase-coenzyme Q10 reductase of gingival biopsies increased (P less than 0.05) during treatment which could correlate with the extraordinarily healing. Treatment of periodontitis with coenzyme Q should be considered as adjunctive treatment with current dental practice.

Topics: Adult; Clinical Trials as Topic; Dental Calculus; Dental Plaque; Diet; Erythrocytes; Gingiva; Humans; Middle Aged; Mitochondria; Oxidoreductases; Periodontal Index; Periodontitis; Succinate Dehydrogenase; Ubiquinone

Mouthwash solutions are mainly used for their antiseptic properties. They currently include synthetic agents (chlorhexidine, triclosan, etc.) or essential oils (especially Listerine). Many natural extracts may also be used. These associate both antiseptic effects and direct action on host response, due to their antioxidant, immunoregulatory, analgesic, buffering, or healing properties. The best known are avocado oil, manuka oil, propolis oil, grapefruit seed extract, pycnogenol, aloe vera, Q10 coenzyme, green tea, and megamin. The development of new technologies, such as microencapsulation (GingiNat concept), may allow an in situ slow release of active ingredients during several hours, and open new perspectives for mouthwash solutions.

Topics: Aloe; Anti-Infective Agents, Local; Antioxidants; Camellia sinensis; Chlorhexidine; Citrus paradisi; Dental Plaque; Drug Compounding; Flavonoids; Gingivitis; Humans; Leptospermum; Mouthwashes; Oils, Volatile; Persea; Plant Extracts; Plant Oils; Propolis; Technology, Pharmaceutical; Triclosan; Ubiquinone; Zeolites