ubiquinone has been researched along with Deficiency-Diseases* in 18 studies
2 review(s) available for ubiquinone and Deficiency-Diseases
Article | Year |
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Selenium and coenzyme Q10 interrelationship in cardiovascular diseases--A clinician's point of view.
A short review is given of the potential role of selenium deficiency and selenium intervention trials in atherosclerotic heart disease. Selenium is an essential constituent of several proteins, including the glutathione peroxidases and selenoprotein P. The selenium intake in Europe is generally in the lower margin of recommendations from authorities. Segments of populations in Europe may thus have a deficient intake that may be presented by a deficient anti-oxidative capacity in various illnesses, in particular atherosclerotic disease, and this may influence the prognosis of the disease. Ischemic heart disease and heart failure are two conditions where increased oxidative stress has been convincingly demonstrated. Some of the intervention studies of anti-oxidative substances that have focused on selenium are discussed in this review. The interrelationship between selenium and coenzyme Q10, another anti-oxidant, is presented, pointing to a theoretical advantage in using both substances in an intervention if there are deficiencies within the population. Clinical results from an intervention study using both selenium and coenzyme Q10 in an elderly population are discussed, where reduction in cardiovascular mortality, a better cardiac function according to echocardiography, and finally a lower concentration of the biomarker NT-proBNP as a sign of lower myocardial wall tension could be seen in those on active treatment, compared to placebo. Topics: Animals; Antioxidants; Ataxia; Cardiovascular Diseases; Coronary Artery Disease; Deficiency Diseases; Diet; Dietary Supplements; Europe; Humans; Mitochondrial Diseases; Muscle Weakness; Nutritional Status; Oxidative Stress; Selenium; Ubiquinone | 2015 |
Survey and new clinical studies on conenzyme Q in human muscular dystrophy.
Topics: Adolescent; Adult; Animals; Avitaminosis; Child; Child, Preschool; Creatine Kinase; Cricetinae; Deficiency Diseases; Electron Transport; Humans; Leukocytes; Male; Mice; Middle Aged; Mitochondria, Muscle; Muscles; Muscular Dystrophies; Muscular Dystrophy, Animal; Oxidoreductases; Rabbits; Succinate Dehydrogenase; Ubiquinone | 1972 |
1 trial(s) available for ubiquinone and Deficiency-Diseases
Article | Year |
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Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study.
Studies have suggested that micronutrient deficiency has some role in the progression of chronic heart failure (CHF).. Oral supplementation with coenzyme Q(10) (CoQ(10)) and creatine may reduce mitochondrial dysfunction that contributes to impaired physical performance in CHF.. We conducted a randomized, double-blind, placebo-controlled trial to determine the effect of a mixture of water-soluble CoQ(10) (CoQ(10) terclatrate; Q-ter) and creatine on exercise tolerance and health-related quality of life. Exercise tolerance was measured as total work capacity (kg·m) and peak oxygen consumption (VO(2), mL/min/kg), both from a cardiopulmonary exercise test. Health-related quality of life was measured by the Sickness Impact Profile (SIP) in CHF secondary to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 35%). After baseline assessment, 67 patients with stable CHF were randomized to receive Q-ter 320 mg + creatine 340 mg (n = 35) or placebo (n = 32) once daily for 8 weeks.. At multivariate analysis, 8-week peak VO(2) was significantly higher in the active treatment group than in the placebo group (+1.8 ± 0.9 mL/min/kg, 95% CI: 0.1-3.6, P < 0.05). No untoward effects occurred in either group.. This study suggests that oral Q-ter and creatine, added to conventional drug therapy, exert some beneficial effect on physical performance in stable systolic CHF. Results may support the design of larger studies aimed at assessing the long-term effects of this treatment on functional status and harder outcomes. Topics: Administration, Oral; Aged; Chi-Square Distribution; Chronic Disease; Creatine; Deficiency Diseases; Dietary Supplements; Double-Blind Method; Drug Combinations; Exercise Test; Exercise Tolerance; Female; Heart Failure; Humans; Male; Medication Adherence; Oxygen Consumption; Placebo Effect; Quality of Life; Stroke Volume; Time Factors; Treatment Outcome; Ubiquinone; Ventricular Function, Left | 2011 |
15 other study(ies) available for ubiquinone and Deficiency-Diseases
Article | Year |
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Coenzyme q10 and creatine in heart failure: micronutrients, macrobenefit?
Topics: Administration, Oral; Chronic Disease; Creatine; Deficiency Diseases; Dietary Supplements; Drug Combinations; Exercise Tolerance; Heart Failure; Humans; Oxygen Consumption; Quality of Life; Stroke Volume; Treatment Outcome; Ubiquinone; Ventricular Function, Left | 2011 |
Deficiency of coenzyme Q in gingiva of patients with periodontal disease.
Topics: Adult; Biopsy; Deficiency Diseases; Enzyme Activation; Female; Gingiva; Humans; Male; Middle Aged; Mitochondria; Oral Hygiene; Oxidoreductases; Periodontal Diseases; Succinate Dehydrogenase; Ubiquinone | 1973 |
[Effect of basic diet and alimentary tocopherol-ubiquinone deficiency in the rat. II. Serum analyses following nutrition with standard diet, semisynthetic diet and following injection with d,l-alpha-tocoperol].
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Deficiency Diseases; Female; Rats; Ubiquinone; Vitamin E; Vitamin E Deficiency | 1973 |
Vitamin activity of coenzyme Q as revealed by normalization of elevated proteolytic and autolytic enzymes in skeletal muscle of antioxidant deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Autolysis; Creatine Kinase; Deficiency Diseases; Female; Lipid Metabolism; Male; Membranes; Muscles; Oxidation-Reduction; Peptide Hydrolases; Peroxides; Rats; Ubiquinone; Vitamin E Deficiency | 1973 |
Deficiency of coenzyme Q 10 in a succinate-CoQ 10 -Enzyme in the dystrophic rabbit on an antioxidant deficient diet.
Topics: Animals; Biological Transport; Deficiency Diseases; Electron Transport; Mitochondria, Muscle; Muscles; Muscular Dystrophy, Animal; Myocardium; Oxidative Phosphorylation; Oxidoreductases; Rabbits; Succinate Dehydrogenase; Ubiquinone; Vitamin E Deficiency | 1972 |
Deficiency of coenzyme Q 10 in human heart disease. I.
Topics: Deficiency Diseases; Electron Transport; Heart Diseases; Heart Septal Defects; Heart Valve Diseases; Humans; Mitochondria, Muscle; Myocardium; Respiration; Succinate Dehydrogenase; Tetralogy of Fallot; Ubiquinone | 1972 |
Deficiency of coenzyme Q 10 in human heart disease. II.
Topics: Adolescent; Adult; Aged; Aspartate Aminotransferases; Atrial Function; Blood Pressure; Cardiovascular Diseases; Child; Child, Preschool; Deficiency Diseases; Electrocardiography; Electron Transport; Female; Heart Diseases; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Oxidative Phosphorylation; Ubiquinone | 1972 |
The vitamin activity of coenzyme Q 7 in reproduction in the rat.
Topics: Animals; Antioxidants; Deficiency Diseases; Electron Transport; Female; Fetal Death; Lipid Metabolism; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Peroxides; Pregnancy; Rats; Succinate Dehydrogenase; Ubiquinone; Uterus; Vitamin E; Vitamin E Deficiency | 1971 |
[Ultrastructure of the rat thyroid epithelial cells during alimentary tocopherol and ubiquinone deficiencies and after substitution].
Topics: Animals; Colloids; Deficiency Diseases; Diet; Endoplasmic Reticulum; Epithelium; Female; Histocytochemistry; Lysosomes; Male; Microscopy, Electron; Mitochondria; Protein Biosynthesis; Rats; Thyroid Gland; Ubiquinone; Vitamin E; Vitamin E Deficiency | 1971 |
[Mechanism of flavonoid effect on respiration and oxidative phosphorylation of mitochondria in rat liver].
Topics: Amino Acids; Animals; Deficiency Diseases; Depression, Chemical; Diet; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rutin; Stimulation, Chemical; Ubiquinone | 1969 |
Deficiency of coenzyme Q10 in the rabbit.
Topics: Animals; Antioxidants; Deficiency Diseases; Disease Models, Animal; Freeze Drying; Kidney; Liver; Muscular Dystrophies; Myocardium; Oxidoreductases; Rabbits; Succinate Dehydrogenase; Ubiquinone; Vitamin E Deficiency | 1969 |
[On rat thyroid gland function after feeding a diet deficient in tocopherol and ubiquinone. 1. Dose-activity relationship of thyrotrophin (TSH)].
Topics: Animals; Deficiency Diseases; Diet; Hypophysectomy; Rats; Thyroid Gland; Thyrotropin; Ubiquinone; Vitamin E Deficiency | 1967 |
[On thyroid gland function in rats after feeding a tocopherol- and ubiquinone-deficient diet. 2. Uptake of 131-iodine and morphokinesis of the rat thyroid gland].
Topics: Animals; Deficiency Diseases; Diet; Female; Hypophysectomy; Iodine; Iodine Isotopes; Male; Rats; Thyroid Gland; Ubiquinone; Vitamin E Deficiency | 1967 |
COENZYME Q. 53. NOVEL FINDING OF ACTIVITY FOR HEXAHYDROCOENZYME Q4 IN THE DYSTROPHIC RABBIT.
Topics: Animals; Clinical Enzyme Tests; Coenzymes; Creatine; Creatinine; Deficiency Diseases; Quinones; Rabbits; Research; Ubiquinone; Urine; Vitamin E Deficiency | 1964 |
EFFECT OF ESSENTIAL FATTY ACID DEFICIENCY AND DIETARY CHOLESTEROL ON LIVER UBIQUINONE LEVELS IN THE RAT.
Topics: Carbon Isotopes; Cholesterol; Cholesterol, Dietary; Deficiency Diseases; Dietary Fats; Fatty Acids; Fatty Acids, Essential; Liver; Metabolism; Mevalonic Acid; Pharmacology; Rats; Research; Ubiquinone | 1964 |