ubiquinone and Carcinoma

ubiquinone has been researched along with Carcinoma* in 4 studies

Other Studies

4 other study(ies) available for ubiquinone and Carcinoma

ArticleYear
Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model.
    Nutrition journal, 2010, Nov-30, Volume: 9

    Matrix Metalloproteinases 2 is a key molecule in cellular invasion and metastasis. Mitochondrial ROS has been established as a mediator of MMP activity. Coenzyme Q(10) contributes to intracellular ROS regulation. Coenzyme Q(10) beneficial effects on cancer are still in controversy but there are indications of Coenzyme Q(10) complementing effect on tamoxifen receiving breast cancer patients.. In this study we aimed to investigate the correlation of the effects of co-incubation of coenzyme Q10 and N-acetyl-L-cysteine (NAC) on intracellular H2O2 content and Matrix Metalloproteinase 2 (MMP-2) activity in MCF-7 cell line.. Our experiment was designed to assess the effect in a time and dose related manner. Gelatin zymography and Flowcytometric measurement of H2O2 by 2'7',-dichlorofluorescin-diacetate probe were employed. The results showed that both coenzyme Q10 and N-acetyl-L-cysteine reduce MMP-2 activity along with the pro-oxidant capacity of the MCF-7 cell in a dose proportionate manner.. Collectively, the present study highlights the significance of Coenzyme Q(10) effect on the cell invasion/metastasis effecter molecules.

    Topics: Acetylcysteine; Biomarkers; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamate-Cysteine Ligase; Humans; Hydrogen Peroxide; Matrix Metalloproteinase 2; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Time Factors; Ubiquinone

2010
Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat.
    BioFactors (Oxford, England), 2005, Volume: 25, Issue:1-4

    High consumption of dietary fat promotes colon carcinogenesis. While this effect is well known the underlying mechanism is not understood. Fatty acid hydroperoxides (LOOH) arise from unsaturated fatty acids in the presence of oxygen and elevated temperature during food processing. An approach was made starting from the assumption that LOOH are present in dietary fats as a result of boiling. LOOH undergoes homolytic cleavage in the presence of iron. We studied their effects on gene expression in colorectal tumour cells using linoleic acid hydroperoxide (LOOH) as model compound. Addition to the medium of LT97 adenoma and SW480 carcinoma cells enhanced the production of hydrogen peroxide. Both cell lines were observed to increase VEGF and COX-II expression based on mRNA. Expression of VEGF was inhibited by caroverine and ubiquinon.

    Topics: Adenoma; Carcinoma; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dietary Fats; Gene Expression Regulation, Neoplastic; Humans; Linoleic Acids; Lipid Peroxides; Organic Chemicals; Pyrazoles; Quinoxalines; Sulfonamides; Tumor Cells, Cultured; Ubiquinone; Vascular Endothelial Growth Factor A

2005
Apparent low levels of ubiquinone in rat and human neoplastic tissues.
    Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie, 1968, Volume: 38, Issue:5

    Topics: Abdominal Muscles; Aged; Animals; Ascites; Carcinoma; Carcinoma, Hepatocellular; Chromatography, Paper; Female; Humans; Intestinal Neoplasms; Intestine, Large; Liver; Liver Neoplasms; Male; Middle Aged; Mitochondria; Mitochondria, Liver; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Oxidoreductases; Stomach Neoplasms; Ubiquinone

1968
THE EFFECT OF COENZYME Q0 ON POTASSIUM TRANSPORT IN THE EHRLICH ASCITES-TUMOR CELL.
    Biochimica et biophysica acta, 1964, Mar-30, Volume: 79

    Topics: Adenosine Triphosphate; Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Dogs; Electron Transport; Glucose; Ion Transport; Ions; Metabolism; Mice; Neoplasms, Experimental; Pharmacology; Polarography; Potassium; Potassium Isotopes; Research; Sodium; Ubiquinone

1964