ubiquinone and Anemia--Aplastic

To observe the clinical efficacy of TCM for reinforcing Shen and activating blood circulation to dredge Channels in auxiliary treating chronic aplastic anemia (CAA), and to explore its mechanism.. Seventy-nine patients with CAA were randomly divided into the treated group treated with TCM plus western medicine and the control group treated with western medicine alone. The clinical efficacy was observed and levels of plasma sFas and sFasL before and after treatment were determined by ELISA.. The basic cure rate and total effective rate in the treated group were 37.50% and 87.50%; while in the control group were 20. 51% and 61.54% respectively. Comparison between the two groups showed significant difference (P < 0.01). The sFas level was markedly lower in both groups before treatment, but after treatment, it got elevated in the treated group significantly (P < 0.05), as compared with that in the control group, the difference was significant (P < 0.01).. TCM is effective in treating CAA with less toxic and side-effect, the mechanism might be the inhibition on over apoptosis of hematopoietic cells in CAA patients through regulating immune function of organism.

Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Apoptosis; Child; Chronic Disease; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hematopoietic Stem Cells; Humans; Male; Middle Aged; Phytotherapy; Single-Blind Method; Ubiquinone

To explore the mechanism of integrated traditional Chinese and Western medicine (TCM-WM) therapy on chronic aplastic anemia (CAA).. The RBC life span of 30 normal human subjects and 30 patients with CAA were measured by 51Cr labelled technique before and after TCM-WM therapy. The morphology and distribution of RBC membrane protein granules were observed by freeze fracture etching and transmission electron microscope.. The half life of erythrocytes (RBC T1/2) was shortened in CAA cases and there was a significant difference compared to healthy control (P < 0.01). After therapy, the RBC life span prolonged and approached the normal level. Before treatment, there existed abnormal in morphology, decrease in amount and uneven in distribution of protein granules in protoplasmic face (PF) and extracellular face (EF) of RBC membrane. After treatment, the protein granules of RBC membrane was improved and approached to control.. The morphology, amount, quality and distribution of RBC membrane protein granule were closely related to its life span. The therapeutic effect of TCM-WM was better than that of WM alone and it had a function both in stabilizing membrane protein and extending the RBC life span.

Topics: Adolescent; Adult; Anemia, Aplastic; Antioxidants; Chronic Disease; Coenzymes; Drugs, Chinese Herbal; Erythrocyte Aging; Erythrocyte Membrane; Female; Humans; Male; Membrane Proteins; Middle Aged; Ubiquinone