ubiquinone has been researched along with Anaphylaxis* in 1 studies
1 other study(ies) available for ubiquinone and Anaphylaxis
| Article | Year |
|---|---|
[Inhibition of the slow-reacting substance of anaphylaxis generation by ubiquinone derivatives].
The slow-reacting substance of anaphylaxis (SRS-A) is generated in lung fragments of the actively sensitized guinea pig by an antigen-antibody reaction. The SRS-A generation in lung fragments was inhibited by its quinonyl acid (QS), and quinonyl-alcohol (QSA) derivatives of ubiquinone from a concentration as low as 10(-7) M. It was of interest that the C10 and C13 side chain length in the 6-position of ubiquinone provided the highest activity. These compounds showed no antagonistic activity towards the contractile response of guinea pig ileum to SRS-A, indicating that the compounds inhibit the biosynthesis of SRS-A. Topics: Anaphylaxis; Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Lung; Male; Muscle, Smooth; SRS-A; Structure-Activity Relationship; Ubiquinone | 1986 |