ubenimex has been researched along with Neoplasms in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (52.63) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 4 (10.53) | 29.6817 |
| 2010's | 10 (26.32) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, H; Li, M; Li, Q; Wang, X; Xu, W; Yuan, Y; Zhang, L; Zhang, X; Zhu, H | 1 |
| Fang, H; Fen, J; Gong, J; Xu, W; Yang, K; Zhang, L | 1 |
| Guenot, D; Hénon, P; Marin, A; Schegg, F; Schmitt, C; Schmitt, M; Tarnus, C; Voegelin, M | 1 |
| Cao, J; Jin, K; Li, X; Ma, C; Xu, W; Zhang, L | 1 |
| Cao, J; Jin, K; Li, X; Liang, X; Ma, C; Xu, W | 1 |
| Cao, J; Chen, T; Dong, H; Kong, X; Ran, Y; Xu, W; Zang, J; Zhang, Y; Zhao, C | 1 |
| Chen, SZ; Li, GJ; Ni, J; Shang, Y; Wang, AM; Wang, C; Wang, WD | 1 |
| Fang, H; Wang, X; Xu, W; Yang, K; Zhang, C; Zhang, J; Zhang, L | 1 |
| Gullbo, J; Larsson, R; Nygren, P; Wickström, M | 1 |
| Fang, H; Feng, J; Jing, F; Li, M; Liu, N; Luan, Y; Ma, C; Sui, Z; Wang, X; Wang, Y; Xu, W | 1 |
| Cheng, YN; Cui, SX; Gao, JJ; Gao, ZH; Qu, XJ; Tang, W; Xu, WF; Xue, X | 1 |
| DuBois, RN | 1 |
| Ehrsson, H; Gullbo, J; Larsson, R; Lewensohn, R; Luthman, K; Nygren, P; Tullberg, M; Wickström, M | 1 |
| Koizumi, K; Minami, T; Saiki, I; Saitoh, Y; Sakurai, H; Sekine, K | 1 |
| Hadden, JW | 1 |
| Wybran, J | 1 |
| Mathé, G; Reizenstein, P | 1 |
| Mathe, G | 4 |
| Hashimoto, I; Kimura, K; Kodama, M; Kurioka, H; Matsumoto, H; Nozaki, A; Sonoyama, T; Terata, N; Tsunoda, F | 1 |
| Oka, S | 2 |
| Aoyagi, T; Umezawa, H | 1 |
| Blomgren, H; Jarstrand, C | 2 |
| Blomgren, H; Edsmyr, F; Strender, LE | 2 |
| Bruley-Rosset, M; Florentin, I; Kiger, N; Mathé, G; Schulz, JI | 1 |
| Blomgren, H; Wasserman, J | 1 |
| Ota, K; Uzuka, Y | 1 |
| Ota, K | 1 |
| Ishida, M; Mega, T; Mori, T; Ogawa, M | 1 |
| Brienza, S; Canon, C; Mathé, G; Misset, JL; Musset, M; Reizenstein, P; Umezawa, H | 1 |
| Blazsek, I; Canon, C; Gil-Delgado, M; Mathé, G; Misset, JL | 1 |
| Himori, T; Konno, K; Kumano, N; Mitachi, Y; Oizumi, K; Suzuki, S; Wakui, A | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
8 review(s) available for ubenimex and Neoplasms
| Article | Year |
|---|---|
Aminopeptidase N (CD13) as a target for cancer chemotherapy.
Topics: CD13 Antigens; Cell Proliferation; Clinical Trials as Topic; Glycine; Humans; Hydroxamic Acids; Leucine; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Prognosis; Protease Inhibitors | 2011 |
LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.
Topics: Angiogenesis Inhibitors; Animals; CD13 Antigens; Cell Membrane; Endothelium, Vascular; Esters; Fibroblast Growth Factor 2; Humans; Leucine; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Transforming Growth Factor alpha; Umbilical Veins; Vascular Endothelial Growth Factor A | 2011 |
Biological response modifiers and differentiation inducers. Current status in cancer research.
Topics: Adjuvants, Immunologic; Aziridines; Bacterial Vaccines; Cell Differentiation; Cyclosporins; Dimethyl Sulfoxide; Glucans; Hormones; Humans; Leucine; Levamisole; Lithium; Neoplasms; Peptides; Retinoids; Selenium | 1983 |
Experience gained in immunotherapy from the immunopharmacology of BCG leading to a second generation of systemic immunity adjuvants.
Topics: Adjuvants, Immunologic; Animals; Aziridines; BCG Vaccine; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Immunologic; Humans; Immunotherapy; Leucine; Leukemia L1210; Leukemia, Lymphoid; Levamisole; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Neoplasms; Propionibacterium acnes; T-Lymphocytes, Regulatory; Thymosin | 1980 |
Clinical trials of bestatin for leukemia and solid tumors.
Topics: Humans; Immunologic Factors; Leucine; Leukemia; Neoplasms | 1992 |
Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function.
Topics: Aminopeptidases; Animals; Antibiotics, Antineoplastic; HIV Infections; Humans; Leucine; Mice; Neoplasms; Neoplasms, Experimental | 1991 |
Review of ubenimex (Bestatin): clinical research.
Topics: Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Humans; Leucine; Leukemia, Myeloid, Acute; Middle Aged; Neoplasms; Prospective Studies | 1991 |
Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system?
Topics: Adjuvants, Immunologic; Animals; Humans; Immunotherapy; Leucine; Neoplasms; Phagocytosis; Tuftsin | 1987 |
5 trial(s) available for ubenimex and Neoplasms
| Article | Year |
|---|---|
A review of clinical studies of bestatin.
Topics: Adjuvants, Immunologic; Adult; Aged; Antibiotics, Antineoplastic; Breast Neoplasms; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Immunotherapy; Leucine; Male; Neoplasms; Penile Neoplasms | 1980 |
A review of clinical studies on bestatin, 1976--1978.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucine; Male; Middle Aged; Neoplasms | 1981 |
Clinical trials of bestatin for leukemia and solid tumors.
Topics: Humans; Immunologic Factors; Leucine; Leukemia; Neoplasms | 1992 |
Review of ubenimex (Bestatin): clinical research.
Topics: Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Humans; Leucine; Leukemia, Myeloid, Acute; Middle Aged; Neoplasms; Prospective Studies | 1991 |
From experimental to clinical attempts in immunorestoration with bestatin and zinc.
Topics: Adjuvants, Immunologic; Age Factors; AIDS-Related Complex; Animals; Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leucine; Lymphocyte Activation; Lymphoma, Non-Hodgkin; Mice; Neoplasms; T-Lymphocytes; Zinc | 1986 |
27 other study(ies) available for ubenimex and Neoplasms
| Article | Year |
|---|---|
Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.
Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Proliferation; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Phenylalanine; Piperidones; Protease Inhibitors; Structure-Activity Relationship; Swine | 2010 |
Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors.
Topics: Antineoplastic Agents; CD13 Antigens; Cell Proliferation; Humans; Leucine; Models, Molecular; Neoplasms; Protease Inhibitors; Serine; Structure-Activity Relationship; Tumor Cells, Cultured | 2012 |
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.
Topics: Angiogenesis Inhibitors; Animals; Anisoles; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Movement; Cycloheptanes; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Molecular Targeted Therapy; Neoplasms | 2013 |
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).
Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Drug Design; Humans; Inhibitory Concentration 50; Leucine; Molecular Docking Simulation; Neoplasms; Protease Inhibitors; Swine | 2013 |
Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).
Topics: CD13 Antigens; Humans; Molecular Docking Simulation; Neoplasms; Protease Inhibitors; Zinc | 2013 |
Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II.
Topics: Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Drug Design; Humans; Leucine; Neoplasms; Protease Inhibitors; Structure-Activity Relationship; Triazoles | 2019 |
FASN Inhibitors Enhance Bestatin-Related Tumor Cell Apoptosis Through Upregulating PEPT1.
Topics: Apoptosis; Cell Line, Tumor; Cerulenin; Fatty Acid Synthase, Type I; Fatty Acid Synthases; Humans; Neoplasms; Orlistat; RNA, Messenger | 2023 |
The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor.
Topics: Animals; Antineoplastic Agents; Binding Sites; CD13 Antigens; Cell Line, Tumor; Computer-Aided Design; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Leucine; Mice; Neoplasms; Oligopeptides; Structure-Activity Relationship; Swine | 2010 |
LYP3, a new bestatin derivative for aminopeptidase N inhibition.
Topics: CD13 Antigens; Cell Line, Tumor; Humans; Leucine; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Molecular Targeted Therapy; Neoplasms; Solubility | 2011 |
Leukotriene A4 signaling, inflammation, and cancer.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Arachidonate 5-Lipoxygenase; Cell Transformation, Neoplastic; Cyclooxygenase Inhibitors; Disease Models, Animal; Epoxide Hydrolases; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Leucine; Leukotriene A4; Neoplasms; Signal Transduction; Up-Regulation | 2003 |
Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dipeptides; Fluorometry; Humans; Hydrolysis; Indicators and Reagents; Leucine; Melphalan; Neoplasms; Oligopeptides; Peptide Hydrolases; Prodrugs; Protease Inhibitors | 2003 |
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
Topics: Aminopeptidases; Animals; Antibiotics, Antineoplastic; Capillaries; Cell Line; Cell Movement; Cell Survival; Endothelial Cells; Extracellular Matrix; Humans; Leucine; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Neoplasms; Protease Inhibitors; Wound Healing | 2006 |
Chemically defined immunotherapeutic agents.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Benzimidazoles; Cimetidine; Ditiocarb; Humans; Hypoxanthines; Inosine Pranobex; Leucine; Levamisole; Mice; Neoplasms; Pyran Copolymer; Tuftsin | 1983 |
The immunopharmacology of synthetic immunomodulators.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Ditiocarb; Glucans; Humans; Hypoxanthines; Immunity; Inosine Pranobex; Interferon Inducers; Leucine; Levamisole; Lynestrenol; Neoplasms | 1983 |
[Study on the antitumor effect of an inhibitor against cell surface enzyme (Bestatin)].
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Humans; Leucine; Male; Mice; Mice, Inbred BALB C; Mitogens; Neoplasms; T-Lymphocytes | 1982 |
The relationships between enzyme inhibitors and function of mammalian cells.
Topics: Animals; Arthritis; Binding, Competitive; Cell Membrane; Chickens; Humans; Leucine; Mice; Muscular Dystrophy, Animal; Neoplasms; Peptide Hydrolases; Protease Inhibitors | 1981 |
Increased granulocyte phagocytosis after oral administration of bestatin, a new immunomodulator.
Topics: Adjuvants, Immunologic; Adult; Aged; Female; Granulocytes; Humans; In Vitro Techniques; Leucine; Male; Middle Aged; Neoplasms; Phagocytosis | 1982 |
Influence of Bestatin, a new immunomodulator, on various functions of human monocytes.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Cell Movement; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Female; Humans; In Vitro Techniques; Leucine; Male; Middle Aged; Monocytes; Neoplasms; Nitroblue Tetrazolium; Phagocytosis | 1982 |
Bestatin treatment and the peripheral lymphocyte population in cancer patients.
Topics: Adjuvants, Immunologic; Antibiotics, Antineoplastic; Cells, Cultured; Humans; Killer Cells, Natural; Leucine; Lymphocytes; Neoplasms; Streptomyces | 1980 |
Correction of immunodeficiency in aged mice by levamisole and bestatin administration.
Topics: Adjuvants, Immunologic; Aging; Animals; Antibody-Dependent Cell Cytotoxicity; Immunologic Deficiency Syndromes; Leucine; Levamisole; Lymphocytes; Macrophages; Mice; Neoplasms | 1980 |
Bestatin treatment of human lymphocytes increases the frequency of sheep red blood cell-binding cells.
Topics: Adjuvants, Immunologic; Adult; Animals; Erythrocytes; Humans; Leucine; Lymphocytes; Neoplasms; Rosette Formation; Sheep | 1981 |
Changes of the blood lymphocyte population in cancer patients treated with bestatin, a new immunomodulator. A phase I study.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Cytotoxicity, Immunologic; Drug Evaluation; Female; Humans; Leucine; Leukocyte Count; Lymphocytes; Male; Middle Aged; Neoplasms; Phytohemagglutinins; Rosette Formation | 1980 |
Immunity, infection, malignancy and aging: possible immunity restoration and tumor prevention.
Topics: Adult; Aged; Aging; Animals; Antibiotics, Antineoplastic; Humans; Immunity; Infections; Leucine; Mice; Middle Aged; Neoplasms | 1989 |
Determination and characterization of succinyl tri-alanine p-nitroanilide hydrolyzing metalloendopeptidase in serum.
Topics: Adult; Aminopeptidases; Anti-Bacterial Agents; Cholestasis; Chromatography, High Pressure Liquid; Diabetes Mellitus; Endopeptidases; Female; Glycopeptides; Humans; Immunodiffusion; Kidney; Leucine; Male; Metalloendopeptidases; Neoplasms; Oligopeptides; Peptides; Protease Inhibitors | 1987 |
Immunomodulating properties of bestatin in cancer patients. A phase II trial.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Drug Evaluation; Humans; Leucine; Neoplasms; T-Lymphocytes | 1986 |
Imbalance of T cell subsets in cancer patients and its modification with bestatin, a small molecular immunomodifier.
Topics: Adjuvants, Immunologic; Aged; Antibodies, Monoclonal; Female; Fluorescent Antibody Technique; Homeostasis; Humans; Leucine; Male; Middle Aged; Neoplasms; T-Lymphocytes | 1985 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |