Page last updated: 2024-08-25

ubenimex and Neoplasms

ubenimex has been researched along with Neoplasms in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199020 (52.63)18.7374
1990's3 (7.89)18.2507
2000's4 (10.53)29.6817
2010's10 (26.32)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Fang, H; Li, M; Li, Q; Wang, X; Xu, W; Yuan, Y; Zhang, L; Zhang, X; Zhu, H1
Fang, H; Fen, J; Gong, J; Xu, W; Yang, K; Zhang, L1
Guenot, D; Hénon, P; Marin, A; Schegg, F; Schmitt, C; Schmitt, M; Tarnus, C; Voegelin, M1
Cao, J; Jin, K; Li, X; Ma, C; Xu, W; Zhang, L1
Cao, J; Jin, K; Li, X; Liang, X; Ma, C; Xu, W1
Cao, J; Chen, T; Dong, H; Kong, X; Ran, Y; Xu, W; Zang, J; Zhang, Y; Zhao, C1
Chen, SZ; Li, GJ; Ni, J; Shang, Y; Wang, AM; Wang, C; Wang, WD1
Fang, H; Wang, X; Xu, W; Yang, K; Zhang, C; Zhang, J; Zhang, L1
Gullbo, J; Larsson, R; Nygren, P; Wickström, M1
Fang, H; Feng, J; Jing, F; Li, M; Liu, N; Luan, Y; Ma, C; Sui, Z; Wang, X; Wang, Y; Xu, W1
Cheng, YN; Cui, SX; Gao, JJ; Gao, ZH; Qu, XJ; Tang, W; Xu, WF; Xue, X1
DuBois, RN1
Ehrsson, H; Gullbo, J; Larsson, R; Lewensohn, R; Luthman, K; Nygren, P; Tullberg, M; Wickström, M1
Koizumi, K; Minami, T; Saiki, I; Saitoh, Y; Sakurai, H; Sekine, K1
Hadden, JW1
Wybran, J1
Mathé, G; Reizenstein, P1
Mathe, G4
Hashimoto, I; Kimura, K; Kodama, M; Kurioka, H; Matsumoto, H; Nozaki, A; Sonoyama, T; Terata, N; Tsunoda, F1
Oka, S2
Aoyagi, T; Umezawa, H1
Blomgren, H; Jarstrand, C2
Blomgren, H; Edsmyr, F; Strender, LE2
Bruley-Rosset, M; Florentin, I; Kiger, N; Mathé, G; Schulz, JI1
Blomgren, H; Wasserman, J1
Ota, K; Uzuka, Y1
Ota, K1
Ishida, M; Mega, T; Mori, T; Ogawa, M1
Brienza, S; Canon, C; Mathé, G; Misset, JL; Musset, M; Reizenstein, P; Umezawa, H1
Blazsek, I; Canon, C; Gil-Delgado, M; Mathé, G; Misset, JL1
Himori, T; Konno, K; Kumano, N; Mitachi, Y; Oizumi, K; Suzuki, S; Wakui, A1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1

Reviews

8 review(s) available for ubenimex and Neoplasms

ArticleYear
Aminopeptidase N (CD13) as a target for cancer chemotherapy.
    Cancer science, 2011, Volume: 102, Issue:3

    Topics: CD13 Antigens; Cell Proliferation; Clinical Trials as Topic; Glycine; Humans; Hydroxamic Acids; Leucine; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Prognosis; Protease Inhibitors

2011
LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.
    Microvascular research, 2011, Volume: 82, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; CD13 Antigens; Cell Membrane; Endothelium, Vascular; Esters; Fibroblast Growth Factor 2; Humans; Leucine; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Transforming Growth Factor alpha; Umbilical Veins; Vascular Endothelial Growth Factor A

2011
Biological response modifiers and differentiation inducers. Current status in cancer research.
    Drugs, 1983, Volume: 26, Issue:3

    Topics: Adjuvants, Immunologic; Aziridines; Bacterial Vaccines; Cell Differentiation; Cyclosporins; Dimethyl Sulfoxide; Glucans; Hormones; Humans; Leucine; Levamisole; Lithium; Neoplasms; Peptides; Retinoids; Selenium

1983
Experience gained in immunotherapy from the immunopharmacology of BCG leading to a second generation of systemic immunity adjuvants.
    Comparative immunology, microbiology and infectious diseases, 1980, Volume: 3, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Aziridines; BCG Vaccine; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Immunologic; Humans; Immunotherapy; Leucine; Leukemia L1210; Leukemia, Lymphoid; Levamisole; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Neoplasms; Propionibacterium acnes; T-Lymphocytes, Regulatory; Thymosin

1980
Clinical trials of bestatin for leukemia and solid tumors.
    Biotherapy (Dordrecht, Netherlands), 1992, Volume: 4, Issue:3

    Topics: Humans; Immunologic Factors; Leucine; Leukemia; Neoplasms

1992
Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1991, Volume: 45, Issue:2-3

    Topics: Aminopeptidases; Animals; Antibiotics, Antineoplastic; HIV Infections; Humans; Leucine; Mice; Neoplasms; Neoplasms, Experimental

1991
Review of ubenimex (Bestatin): clinical research.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1991, Volume: 45, Issue:2-3

    Topics: Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Humans; Leucine; Leukemia, Myeloid, Acute; Middle Aged; Neoplasms; Prospective Studies

1991
Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system?
    Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc, 1987, Volume: 1

    Topics: Adjuvants, Immunologic; Animals; Humans; Immunotherapy; Leucine; Neoplasms; Phagocytosis; Tuftsin

1987

Trials

5 trial(s) available for ubenimex and Neoplasms

ArticleYear
A review of clinical studies of bestatin.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 75

    Topics: Adjuvants, Immunologic; Adult; Aged; Antibiotics, Antineoplastic; Breast Neoplasms; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Immunotherapy; Leucine; Male; Neoplasms; Penile Neoplasms

1980
A review of clinical studies on bestatin, 1976--1978.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1981, Volume: 76

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucine; Male; Middle Aged; Neoplasms

1981
Clinical trials of bestatin for leukemia and solid tumors.
    Biotherapy (Dordrecht, Netherlands), 1992, Volume: 4, Issue:3

    Topics: Humans; Immunologic Factors; Leucine; Leukemia; Neoplasms

1992
Review of ubenimex (Bestatin): clinical research.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1991, Volume: 45, Issue:2-3

    Topics: Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Humans; Leucine; Leukemia, Myeloid, Acute; Middle Aged; Neoplasms; Prospective Studies

1991
From experimental to clinical attempts in immunorestoration with bestatin and zinc.
    Comparative immunology, microbiology and infectious diseases, 1986, Volume: 9, Issue:2-3

    Topics: Adjuvants, Immunologic; Age Factors; AIDS-Related Complex; Animals; Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leucine; Lymphocyte Activation; Lymphoma, Non-Hodgkin; Mice; Neoplasms; T-Lymphocytes; Zinc

1986

Other Studies

27 other study(ies) available for ubenimex and Neoplasms

ArticleYear
Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.
    Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

    Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Proliferation; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Phenylalanine; Piperidones; Protease Inhibitors; Structure-Activity Relationship; Swine

2010
Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2012, Volume: 27, Issue:2

    Topics: Antineoplastic Agents; CD13 Antigens; Cell Proliferation; Humans; Leucine; Models, Molecular; Neoplasms; Protease Inhibitors; Serine; Structure-Activity Relationship; Tumor Cells, Cultured

2012
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Anisoles; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Movement; Cycloheptanes; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Molecular Targeted Therapy; Neoplasms

2013
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Drug Design; Humans; Inhibitory Concentration 50; Leucine; Molecular Docking Simulation; Neoplasms; Protease Inhibitors; Swine

2013
Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).
    Bioorganic & medicinal chemistry letters, 2013, Sep-01, Volume: 23, Issue:17

    Topics: CD13 Antigens; Humans; Molecular Docking Simulation; Neoplasms; Protease Inhibitors; Zinc

2013
Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II.
    Bioorganic & medicinal chemistry, 2019, 03-15, Volume: 27, Issue:6

    Topics: Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Drug Design; Humans; Leucine; Neoplasms; Protease Inhibitors; Structure-Activity Relationship; Triazoles

2019
FASN Inhibitors Enhance Bestatin-Related Tumor Cell Apoptosis Through Upregulating PEPT1.
    Current molecular pharmacology, 2023, Volume: 16, Issue:7

    Topics: Apoptosis; Cell Line, Tumor; Cerulenin; Fatty Acid Synthase, Type I; Fatty Acid Synthases; Humans; Neoplasms; Orlistat; RNA, Messenger

2023
The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:10

    Topics: Animals; Antineoplastic Agents; Binding Sites; CD13 Antigens; Cell Line, Tumor; Computer-Aided Design; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Leucine; Mice; Neoplasms; Oligopeptides; Structure-Activity Relationship; Swine

2010
LYP3, a new bestatin derivative for aminopeptidase N inhibition.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2011, Volume: 7, Issue:1

    Topics: CD13 Antigens; Cell Line, Tumor; Humans; Leucine; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Molecular Targeted Therapy; Neoplasms; Solubility

2011
Leukotriene A4 signaling, inflammation, and cancer.
    Journal of the National Cancer Institute, 2003, Jul-16, Volume: 95, Issue:14

    Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Arachidonate 5-Lipoxygenase; Cell Transformation, Neoplastic; Cyclooxygenase Inhibitors; Disease Models, Animal; Epoxide Hydrolases; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Leucine; Leukotriene A4; Neoplasms; Signal Transduction; Up-Regulation

2003
Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.
    Journal of drug targeting, 2003, Volume: 11, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dipeptides; Fluorometry; Humans; Hydrolysis; Indicators and Reagents; Leucine; Melphalan; Neoplasms; Oligopeptides; Peptide Hydrolases; Prodrugs; Protease Inhibitors

2003
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:4

    Topics: Aminopeptidases; Animals; Antibiotics, Antineoplastic; Capillaries; Cell Line; Cell Movement; Cell Survival; Endothelial Cells; Extracellular Matrix; Humans; Leucine; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Neoplasms; Protease Inhibitors; Wound Healing

2006
Chemically defined immunotherapeutic agents.
    Progress in clinical and biological research, 1983, Volume: 132E

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Benzimidazoles; Cimetidine; Ditiocarb; Humans; Hypoxanthines; Inosine Pranobex; Leucine; Levamisole; Mice; Neoplasms; Pyran Copolymer; Tuftsin

1983
The immunopharmacology of synthetic immunomodulators.
    Progress in clinical and biological research, 1983, Volume: 132E

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Ditiocarb; Glucans; Humans; Hypoxanthines; Immunity; Inosine Pranobex; Interferon Inducers; Leucine; Levamisole; Lynestrenol; Neoplasms

1983
[Study on the antitumor effect of an inhibitor against cell surface enzyme (Bestatin)].
    Nihon Gan Chiryo Gakkai shi, 1982, Aug-20, Volume: 17, Issue:5

    Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Humans; Leucine; Male; Mice; Mice, Inbred BALB C; Mitogens; Neoplasms; T-Lymphocytes

1982
The relationships between enzyme inhibitors and function of mammalian cells.
    Acta biologica et medica Germanica, 1981, Volume: 40, Issue:10-11

    Topics: Animals; Arthritis; Binding, Competitive; Cell Membrane; Chickens; Humans; Leucine; Mice; Muscular Dystrophy, Animal; Neoplasms; Peptide Hydrolases; Protease Inhibitors

1981
Increased granulocyte phagocytosis after oral administration of bestatin, a new immunomodulator.
    Journal of clinical & laboratory immunology, 1982, Volume: 7, Issue:2

    Topics: Adjuvants, Immunologic; Adult; Aged; Female; Granulocytes; Humans; In Vitro Techniques; Leucine; Male; Middle Aged; Neoplasms; Phagocytosis

1982
Influence of Bestatin, a new immunomodulator, on various functions of human monocytes.
    Journal of clinical & laboratory immunology, 1982, Volume: 9, Issue:3

    Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Cell Movement; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Female; Humans; In Vitro Techniques; Leucine; Male; Middle Aged; Monocytes; Neoplasms; Nitroblue Tetrazolium; Phagocytosis

1982
Bestatin treatment and the peripheral lymphocyte population in cancer patients.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 75

    Topics: Adjuvants, Immunologic; Antibiotics, Antineoplastic; Cells, Cultured; Humans; Killer Cells, Natural; Leucine; Lymphocytes; Neoplasms; Streptomyces

1980
Correction of immunodeficiency in aged mice by levamisole and bestatin administration.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 75

    Topics: Adjuvants, Immunologic; Aging; Animals; Antibody-Dependent Cell Cytotoxicity; Immunologic Deficiency Syndromes; Leucine; Levamisole; Lymphocytes; Macrophages; Mice; Neoplasms

1980
Bestatin treatment of human lymphocytes increases the frequency of sheep red blood cell-binding cells.
    Cancer letters, 1981, Volume: 11, Issue:4

    Topics: Adjuvants, Immunologic; Adult; Animals; Erythrocytes; Humans; Leucine; Lymphocytes; Neoplasms; Rosette Formation; Sheep

1981
Changes of the blood lymphocyte population in cancer patients treated with bestatin, a new immunomodulator. A phase I study.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1980, Volume: 32, Issue:4

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Cytotoxicity, Immunologic; Drug Evaluation; Female; Humans; Leucine; Leukocyte Count; Lymphocytes; Male; Middle Aged; Neoplasms; Phytohemagglutinins; Rosette Formation

1980
Immunity, infection, malignancy and aging: possible immunity restoration and tumor prevention.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1989, Volume: 43, Issue:8

    Topics: Adult; Aged; Aging; Animals; Antibiotics, Antineoplastic; Humans; Immunity; Infections; Leucine; Mice; Middle Aged; Neoplasms

1989
Determination and characterization of succinyl tri-alanine p-nitroanilide hydrolyzing metalloendopeptidase in serum.
    Enzyme, 1987, Volume: 37, Issue:4

    Topics: Adult; Aminopeptidases; Anti-Bacterial Agents; Cholestasis; Chromatography, High Pressure Liquid; Diabetes Mellitus; Endopeptidases; Female; Glycopeptides; Humans; Immunodiffusion; Kidney; Leucine; Male; Metalloendopeptidases; Neoplasms; Oligopeptides; Peptides; Protease Inhibitors

1987
Immunomodulating properties of bestatin in cancer patients. A phase II trial.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1986, Volume: 40, Issue:10

    Topics: Adjuvants, Immunologic; Antineoplastic Agents; Drug Evaluation; Humans; Leucine; Neoplasms; T-Lymphocytes

1986
Imbalance of T cell subsets in cancer patients and its modification with bestatin, a small molecular immunomodifier.
    The Tohoku journal of experimental medicine, 1985, Volume: 147, Issue:2

    Topics: Adjuvants, Immunologic; Aged; Antibodies, Monoclonal; Female; Fluorescent Antibody Technique; Homeostasis; Humans; Leucine; Male; Middle Aged; Neoplasms; T-Lymphocytes

1985
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007