Page last updated: 2024-08-25

ubenimex and Lung Neoplasms

ubenimex has been researched along with Lung Neoplasms in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (15.00)	18.7374
1990's	6 (30.00)	18.2507
2000's	3 (15.00)	29.6817
2010's	4 (20.00)	24.3611
2020's	4 (20.00)	2.80

Authors

Authors	Studies
Cao, J; Huang, Y; Li, Y; Liang, X; Ma, C; Wu, P; Xu, W; Zhang, Y	1
Cao, J; Ding, Q; Gao, Q; Gao, S; Kong, X; Liang, X; Ma, C; Wang, B; Xu, W; Yan, Y; Zang, J; Zhang, Y; Zhao, C	1
Chen, Q; Chen, X; Ge, P; Wu, B; Zhang, P	1
Fan, K; Huang, A; Li, C; Li, J; Wan, L; Xing, S; Zhai, W	1
Ding, GG; Ling, XA; Wan, J; Wang, J; Wang, X	1
Hu, X; Huang, S; Mao, T; Su, T; Xiong, H; Yang, L	1
Cui, DX; Gao, ZQ; Guo, XX; Liu, SM; Ma, WQ; Wang, B; Wang, XJ; Zhang, XR; Zhao, TK	1
Li, Y; Liu, XJ; Wu, SY; Zhen, YS; Zheng, YB	1
Ito, S; Miyahara, R; Nagai, S; Takahashi, R; Takenaka, K; Tanaka, F; Wada, H	1
Genka, K; Ichinose, Y; Iioka, S; Kato, H; Koike, T; Mori, T; Ohta, M; Sakuma, A; Watanabe, Y	1
Abe, F; Ichimura, E; Nakajima, T; Nishikawa, K; Yamada, M	1
Ashida, C; Gose, K; Hamada, F; Ichiyanagi, A; Imajo, Y; Imanaka, K; Inomata, Y; Kimura, S; Ogawa, Y; Takada, Y	1
Umezawa, H	1
Fukuoka, M; Furuse, K; Genka, K; Ishikawa, S; Kato, H; Kinuwaki, E; Nakai, H; Nakano, M; Ohta, M; Tsubura, E	1
Dobashi, K; Ezawa, K; Minato, K	1
Mouritzen, C	1
Fukuoka, M; Kudo, S; Kusunoki, Y; Masuda, N; Matsui, K; Negoro, S; Ryu, S; Sakai, N; Takada, M; Takifuji, N	1
Kotake, Y; Nakano, N; Ohshima, S; Tominaga, S; Yasumitsu, T	1
Abe, F; Black, PL; Pelus, LM; Talmadge, JE	1
Abe, F; Alvord, G; Koyama, M; Matsuda, A; Talmadge, JE	1

Reviews

1 review(s) available for ubenimex and Lung Neoplasms

Article	Year
Efficacy of Standardised Treatments Combined with Ubenimex in Patients with Malignant Tumors. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2021, Volume: 31, Issue:2 Topics: Carcinoma, Non-Small-Cell Lung; Humans; Leucine; Lung Neoplasms; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Survival Rate	2021

Trials

5 trial(s) available for ubenimex and Lung Neoplasms

Article	Year
Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma. Journal of the National Cancer Institute, 2003, Apr-16, Volume: 95, Issue:8 Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Confidence Intervals; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Protease Inhibitors; Survival Analysis; Time Factors; Treatment Failure; Treatment Outcome	2003
[Double blind controlled study of ubenimex (Bestatin) against squamous cell lung cancer--a multicenter cooperative study]. Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:9 Topics: Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Double-Blind Method; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Radiotherapy Dosage; Survival Rate	1993
Bestatin as adjuvant treatment in operated stage I and stage II non-small cell lung cancer. European Lung Cancer Study Group. Acta oncologica (Stockholm, Sweden), 1990, Volume: 29, Issue:6 Topics: Aged; Antibiotics, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Humans; Leucine; Lung Neoplasms; Lymph Nodes; Neoplasm Staging; Survival Analysis	1990
Combination therapy with bestatin in inoperable lung cancer. A randomized trial. Acta oncologica (Stockholm, Sweden), 1990, Volume: 29, Issue:6 Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Survival Analysis	1990
Bestatin in resected lung cancer. A randomized clinical trial. Acta oncologica (Stockholm, Sweden), 1990, Volume: 29, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Survival Analysis	1990

Other Studies

14 other study(ies) available for ubenimex and Lung Neoplasms

Article	Year
Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation. European journal of medicinal chemistry, 2016, Jan-27, Volume: 108 Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship	2016
Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12 Topics: Animals; Antineoplastic Agents; Binding Sites; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Docking Simulation; Neovascularization, Physiologic; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship	2018
Ubenimex Combined with Pemetrexed Upregulates SOCS1 to Inhibit Lung Adenocarcinoma Progression via the JAK2-STAT3 Signaling Pathway. Disease markers, 2022, Volume: 2022 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Humans; Janus Kinase 2; Leucine; Lung Neoplasms; Mice; Mice, Nude; Pemetrexed; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein	2022
MicroRNA-125a attenuates the chemoresistance against ubenimex in non-small cell lung carcinoma via targeting the aminopeptidase N signaling pathway. Journal of cellular biochemistry, 2020, Volume: 121, Issue:2 Topics: Antibiotics, Antineoplastic; Apoptosis; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; CD13 Antigens; Cell Cycle; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; MicroRNAs; Prognosis; Tumor Cells, Cultured	2020
Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P-glycoprotein expression level in non-small lung cancer. Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:21 Topics: A549 Cells; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; Mice, Inbred C57BL; Mice, Nude; RNA, Messenger	2020
Preliminary detection of the anti‑tumour activity of indoline‑2,3‑dione derivative DH‑12a targeting aminopeptidase N. Molecular medicine reports, 2014, Volume: 10, Issue:5 Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Hydroxamic Acids; Indoles; Inhibitory Concentration 50; Leucine; Lung Neoplasms; Mice; Tumor Burden; Xenograft Model Antitumor Assays	2014
A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice. PloS one, 2014, Volume: 9, Issue:12 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Dexamethasone; Dipyridamole; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tumor Microenvironment; Vasodilator Agents; Xenograft Model Antitumor Assays	2014
Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer. General thoracic and cardiovascular surgery, 2009, Volume: 57, Issue:11 Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; CD13 Antigens; Chemotherapy, Adjuvant; Female; Fibroblasts; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Leucine; Lung Neoplasms; Lymph Node Excision; Male; Microvessels; Middle Aged; Neovascularization, Pathologic; Pneumonectomy; Retrospective Studies; Time Factors; Treatment Outcome	2009
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy. Pathology international, 2006, Volume: 56, Issue:6 Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; CD13 Antigens; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Leucine; Lung Neoplasms; Male; Middle Aged; Tissue Array Analysis	2006
[Clinical evaluation of bestatin (NK-421) supplementing radiotherapy in the treatment of lung cancer]. Nihon Gan Chiryo Gakkai shi, 1983, Aug-20, Volume: 18, Issue:5 Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Radiotherapy Dosage	1983
Recent studies on antibiotics and small molecular immunomodulators with potential usefulness in treating lung cancer: Part II - Small molecular weight immunomodulators produced by microorganisms. International journal of clinical pharmacology, therapy, and toxicology, 1982, Volume: 20, Issue:1 Topics: Adjuvants, Immunologic; Aminopeptidases; Animals; Antibiotics, Antineoplastic; Drug Evaluation, Preclinical; Humans; Immunity, Cellular; Leucine; Lung Neoplasms; Mice; Molecular Weight; Neoplasms, Experimental	1982
Induction of apoptosis by ubenimex (Bestatin) in human non-small-cell lung cancer cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1996, Volume: 50, Issue:6-7 Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Squamous Cell; Cell Division; DNA Fragmentation; Humans; Leucine; Lung Neoplasms; Tumor Cells, Cultured	1996
Hematopoietic and hematologic properties of bestatin in normal and cyclophosphamide myelosuppressed mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1990, Volume: 44, Issue:2 Topics: Aminopeptidases; Animals; Bone Marrow; Cell Count; Cyclophosphamide; Drug Therapy, Combination; Hematopoietic Stem Cells; Immune Tolerance; Leucine; Lung Neoplasms; Melanoma, Experimental; Mice	1990
Pharmacokinetics of bestatin and oral activity for treatment of experimental metastases. Cancer immunology, immunotherapy : CII, 1989, Volume: 28, Issue:1 Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Drug Administration Schedule; Injections, Intravenous; Leucine; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL	1989