ubenimex has been researched along with Cancer of Lung in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, J; Huang, Y; Li, Y; Liang, X; Ma, C; Wu, P; Xu, W; Zhang, Y | 1 |
| Cao, J; Ding, Q; Gao, Q; Gao, S; Kong, X; Liang, X; Ma, C; Wang, B; Xu, W; Yan, Y; Zang, J; Zhang, Y; Zhao, C | 1 |
| Chen, Q; Chen, X; Ge, P; Wu, B; Zhang, P | 1 |
| Fan, K; Huang, A; Li, C; Li, J; Wan, L; Xing, S; Zhai, W | 1 |
| Ding, GG; Ling, XA; Wan, J; Wang, J; Wang, X | 1 |
| Hu, X; Huang, S; Mao, T; Su, T; Xiong, H; Yang, L | 1 |
| Cui, DX; Gao, ZQ; Guo, XX; Liu, SM; Ma, WQ; Wang, B; Wang, XJ; Zhang, XR; Zhao, TK | 1 |
| Li, Y; Liu, XJ; Wu, SY; Zhen, YS; Zheng, YB | 1 |
| Ito, S; Miyahara, R; Nagai, S; Takahashi, R; Takenaka, K; Tanaka, F; Wada, H | 1 |
| Genka, K; Ichinose, Y; Iioka, S; Kato, H; Koike, T; Mori, T; Ohta, M; Sakuma, A; Watanabe, Y | 1 |
| Abe, F; Ichimura, E; Nakajima, T; Nishikawa, K; Yamada, M | 1 |
| Ashida, C; Gose, K; Hamada, F; Ichiyanagi, A; Imajo, Y; Imanaka, K; Inomata, Y; Kimura, S; Ogawa, Y; Takada, Y | 1 |
| Umezawa, H | 1 |
| Fukuoka, M; Furuse, K; Genka, K; Ishikawa, S; Kato, H; Kinuwaki, E; Nakai, H; Nakano, M; Ohta, M; Tsubura, E | 1 |
| Dobashi, K; Ezawa, K; Minato, K | 1 |
| Mouritzen, C | 1 |
| Fukuoka, M; Kudo, S; Kusunoki, Y; Masuda, N; Matsui, K; Negoro, S; Ryu, S; Sakai, N; Takada, M; Takifuji, N | 1 |
| Kotake, Y; Nakano, N; Ohshima, S; Tominaga, S; Yasumitsu, T | 1 |
| Abe, F; Black, PL; Pelus, LM; Talmadge, JE | 1 |
| Abe, F; Alvord, G; Koyama, M; Matsuda, A; Talmadge, JE | 1 |
1 review(s) available for ubenimex and Cancer of Lung
| Article | Year |
|---|---|
Efficacy of Standardised Treatments Combined with Ubenimex in Patients with Malignant Tumors.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Leucine; Lung Neoplasms; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Survival Rate | 2021 |
5 trial(s) available for ubenimex and Cancer of Lung
| Article | Year |
|---|---|
Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Confidence Intervals; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Protease Inhibitors; Survival Analysis; Time Factors; Treatment Failure; Treatment Outcome | 2003 |
[Double blind controlled study of ubenimex (Bestatin) against squamous cell lung cancer--a multicenter cooperative study].
Topics: Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Double-Blind Method; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Radiotherapy Dosage; Survival Rate | 1993 |
Bestatin as adjuvant treatment in operated stage I and stage II non-small cell lung cancer. European Lung Cancer Study Group.
Topics: Aged; Antibiotics, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Humans; Leucine; Lung Neoplasms; Lymph Nodes; Neoplasm Staging; Survival Analysis | 1990 |
Combination therapy with bestatin in inoperable lung cancer. A randomized trial.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Survival Analysis | 1990 |
Bestatin in resected lung cancer. A randomized clinical trial.
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Survival Analysis | 1990 |
14 other study(ies) available for ubenimex and Cancer of Lung
| Article | Year |
|---|---|
Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.
Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship | 2016 |
Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry.
Topics: Animals; Antineoplastic Agents; Binding Sites; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Docking Simulation; Neovascularization, Physiologic; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship | 2018 |
Ubenimex Combined with Pemetrexed Upregulates SOCS1 to Inhibit Lung Adenocarcinoma Progression via the JAK2-STAT3 Signaling Pathway.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Humans; Janus Kinase 2; Leucine; Lung Neoplasms; Mice; Mice, Nude; Pemetrexed; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein | 2022 |
MicroRNA-125a attenuates the chemoresistance against ubenimex in non-small cell lung carcinoma via targeting the aminopeptidase N signaling pathway.
Topics: Antibiotics, Antineoplastic; Apoptosis; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; CD13 Antigens; Cell Cycle; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; MicroRNAs; Prognosis; Tumor Cells, Cultured | 2020 |
Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P-glycoprotein expression level in non-small lung cancer.
Topics: A549 Cells; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; Mice, Inbred C57BL; Mice, Nude; RNA, Messenger | 2020 |
Preliminary detection of the anti‑tumour activity of indoline‑2,3‑dione derivative DH‑12a targeting aminopeptidase N.
Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Hydroxamic Acids; Indoles; Inhibitory Concentration 50; Leucine; Lung Neoplasms; Mice; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Dexamethasone; Dipyridamole; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tumor Microenvironment; Vasodilator Agents; Xenograft Model Antitumor Assays | 2014 |
Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; CD13 Antigens; Chemotherapy, Adjuvant; Female; Fibroblasts; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Leucine; Lung Neoplasms; Lymph Node Excision; Male; Microvessels; Middle Aged; Neovascularization, Pathologic; Pneumonectomy; Retrospective Studies; Time Factors; Treatment Outcome | 2009 |
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; CD13 Antigens; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Leucine; Lung Neoplasms; Male; Middle Aged; Tissue Array Analysis | 2006 |
[Clinical evaluation of bestatin (NK-421) supplementing radiotherapy in the treatment of lung cancer].
Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Radiotherapy Dosage | 1983 |
Recent studies on antibiotics and small molecular immunomodulators with potential usefulness in treating lung cancer: Part II - Small molecular weight immunomodulators produced by microorganisms.
Topics: Adjuvants, Immunologic; Aminopeptidases; Animals; Antibiotics, Antineoplastic; Drug Evaluation, Preclinical; Humans; Immunity, Cellular; Leucine; Lung Neoplasms; Mice; Molecular Weight; Neoplasms, Experimental | 1982 |
Induction of apoptosis by ubenimex (Bestatin) in human non-small-cell lung cancer cell lines.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Squamous Cell; Cell Division; DNA Fragmentation; Humans; Leucine; Lung Neoplasms; Tumor Cells, Cultured | 1996 |
Hematopoietic and hematologic properties of bestatin in normal and cyclophosphamide myelosuppressed mice.
Topics: Aminopeptidases; Animals; Bone Marrow; Cell Count; Cyclophosphamide; Drug Therapy, Combination; Hematopoietic Stem Cells; Immune Tolerance; Leucine; Lung Neoplasms; Melanoma, Experimental; Mice | 1990 |
Pharmacokinetics of bestatin and oral activity for treatment of experimental metastases.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Drug Administration Schedule; Injections, Intravenous; Leucine; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL | 1989 |