u-75412e and Retinal-Degeneration

u-75412e has been researched along with Retinal-Degeneration* in 1 studies

Other Studies

1 other study(ies) available for u-75412e and Retinal-Degeneration

ArticleYear
Retinal toxicity of intravitreal lazaroid (21-aminosteroid U75412E).
    International ophthalmology, 1992, Volume: 16, Issue:3

    The 21-aminosteroids or lazaroids are a novel series of compounds being developed for the acute treatment of traumatic or ischemic injury of the nervous system. These compounds were specifically designed to localize within cell membranes and inhibit lipid peroxidation reactions. In this study, 21-aminosteroid U75412E was injected into the vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues. Doses ranged from 20 micrograms to 200 micrograms. Retinal toxicity was determined through light and transmission electron microscopy and electroretinography. No retinal toxicity was noted in doses of 30 micrograms and below.

    Topics: Animals; Antioxidants; Electroretinography; Injections; Rabbits; Retina; Retinal Degeneration; Steroids; Vitreous Body

1992