u-75412e and Disease-Models--Animal

u-75412e has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for u-75412e and Disease-Models--Animal

Article	Year
A free radical scavenger (Lazaroid U75412E) attenuates tumor necrosis factor-alpha generation in a rabbit model of smoke-induced lung injury. Respiration; international review of thoracic diseases, 1997, Volume: 64, Issue:5 The lazaroid (21-aminosteroid) analogue U75412E was evaluated in rabbits exposed to diesel fuel-polycarbonate plastic smoke. Inhalation of total of 4.6 mg U75412E aerosolized at a rate of 1.53 mg/min for 3 min before or after smoke significantly prevented or limited the extent of alveolar hypoventilation, interstitial edema, and tumor necrosis factor-alpha (TNF-alpha) by pulmonary alveolar macrophages (PAM) ex vivo observed at 2 h. The smoke-induced changes in wet lung/body weight ratios and the production of superoxide (O2-) by PAM ex vivo were also attenuated by the drug treatment after smoke exposure (p < 0.05). This study suggests that lazaroids may ameliorate the oxygen-radical-initiated cytokine processes and inflammation cascade as a result of the smoke insult. Topics: Analysis of Variance; Animals; Antioxidants; Biological Assay; Disease Models, Animal; Female; Lung; Macrophages, Alveolar; Necrosis; Pulmonary Gas Exchange; Rabbits; Smoke Inhalation Injury; Steroids; Tumor Necrosis Factor-alpha	1997

Article

Year

A free radical scavenger (Lazaroid U75412E) attenuates tumor necrosis factor-alpha generation in a rabbit model of smoke-induced lung injury.

Respiration; international review of thoracic diseases, 1997, Volume: 64, Issue:5

The lazaroid (21-aminosteroid) analogue U75412E was evaluated in rabbits exposed to diesel fuel-polycarbonate plastic smoke. Inhalation of total of 4.6 mg U75412E aerosolized at a rate of 1.53 mg/min for 3 min before or after smoke significantly prevented or limited the extent of alveolar hypoventilation, interstitial edema, and tumor necrosis factor-alpha (TNF-alpha) by pulmonary alveolar macrophages (PAM) ex vivo observed at 2 h. The smoke-induced changes in wet lung/body weight ratios and the production of superoxide (O2-) by PAM ex vivo were also attenuated by the drug treatment after smoke exposure (p < 0.05). This study suggests that lazaroids may ameliorate the oxygen-radical-initiated cytokine processes and inflammation cascade as a result of the smoke insult.

Topics: Analysis of Variance; Animals; Antioxidants; Biological Assay; Disease Models, Animal; Female; Lung; Macrophages, Alveolar; Necrosis; Pulmonary Gas Exchange; Rabbits; Smoke Inhalation Injury; Steroids; Tumor Necrosis Factor-alpha

1997