Page last updated: 2024-08-26

u 74006f and Subarachnoid Hemorrhage

u 74006f has been researched along with Subarachnoid Hemorrhage in 57 studies

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-19905 (8.77)18.7374
1990's29 (50.88)18.2507
2000's17 (29.82)29.6817
2010's6 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baker, A; Levine, MA; Lo, BW; Macdonald, RL1
Guha, D; Ibrahim, GM; Kertzer, JD; Macdonald, RL1
Budohoski, KP; Bulters, DO; Helmy, A; Karri, SK; Kirkpatrick, PJ; Kirollos, RW; Ogilvy, CS; Trivedi, RA; Young, AM1
Cahill, L; Hall, ED1
Ilodigwe, D; Jang, YG; Macdonald, RL1
Lipsman, N; Macdonald, RL; Tolentino, J1
Howard, G; Ilodigwe, D; Knappertz, V; Kreiter, KT; Macdonald, RL; Mayer, SA; Sloan, MA1
Liu, M; Wang, L; Wu, B; Zhang, S1
Ilodigwe, D; Kassell, NF; Kerr, RS; Macdonald, RL; Molyneux, AJ; Murray, GD; Torner, J1
Huo, D; Karrison, T; Macdonald, RL; Rosengart, A1
Macdonald, RL; Rosen, DS1
Baldwin, ME; Frank, JI; Goldenberg, FD; Huo, D; Macdonald, RL; Novakovic, R; Rosen, D; Rosengart, AJ1
Claassen, J; Connolly, ES; Frontera, JA; MacDonald, RL; Mayer, SA; Schmidt, JM; Temes, R; Wartenberg, KE1
Ferguson, S; Macdonald, RL1
Frank, JI; Goldenberg, FD; Huo, JD; Macdonald, RL; Novakovic, RL; Rosengart, AJ; Tolentino, J1
Frank, JI; Goldenberg, FD; Huo, D; Macdonald, RL; Novakovic, RL; Rosen, DS; Rosengart, AJ1
Diringer, MN; Keyrouz, SG1
Alen, JF; Gómez, PA; Lagares, A; Lobato, RD1
Alves, WM; Haley, EC; Hansen, CA; Kassell, NF; Weir, BK1
Means, ED1
Fleishaker, JC; Hulst, LK; Peters, GR1
Hall, ED; McCall, JM; Means, ED1
Asano, T; Matsui, T1
Hall, ED; Scherch, HM; Smith, SL1
Alves, WM; Apperson-Hansen, C; Haley, EC; Kassell, NF1
Hall, ED2
Melon, E; Rimaniol, JM1
Hans, P1
Astrup, J; Sunde, N; Tange, M; Voldby, B1
Jakobsen, M1
Alves, WM; Apperson-Hansen, C; Haley, EC; Kassell, NF; Maile, MH1
Kassell, NF; Kwan, AL; Lee, KS; Solenski, NJ1
Alves, WM; Glick, HA; Kassell, N; Polsky, D; Schulman, K; Willke, RJ1
Alves, WM; Glick, H; Kassell, N; Llana, T; Polsky, D; Schulman, K; Willke, R1
Bricolo, A; Fearnside, M; Iannotti, F; Klauber, MR; Lagarrigue, J; Lobato, R; Maas, AI; Marshall, LF; Marshall, SB; Means, ED; Morris, GF; Musch, B; Persson, L; Pickard, JD; Piek, J; Servadei, F; Wellis, GN1
Mee, EW; Ogden, JA; Utley, T1
Picozzi, P; Tommasino, C1
Glick, HA; Polsky, D; Schulman, K; Willke, RJ1
Kanamaru, K; Kuroki, M; Miyazawa, T; Sun, H; Suzuki, H; Waga, S1
Fiedler-Kelly, J; Fleishaker, JC; Grasela, TH1
Dorsch, NW1
Alves, WM; Brandt, L; Dorsch, NW; Kassell, NF; Lanzino, G; Pasqualin, A; Schmiedek, P; Truskowski, LL1
Kassell, NF; Lanzino, G1
Baskaya, MK; Kassell, NF; Polin, RS; Sheehan, JM; Sheehan, JP1
Baskaya, MK; Coenen, VA; Hansen, CA; Kassell, NF; Nanda, A; Polin, RS; Shin, P1
Cottrell, JE; Hartung, J1
Dorsch, NW; Kassell, NF; Sinkula, MS1
Kam, PC; Kavanagh, RJ1
Danilewicz, B; Stachura, K1
Adinolfi, D; Gaetani, P; Lombardi, D; Marzatico, F; Rodriguez y Baena, R1
Grace, M; Kanamaru, K; Simpson, I; Weir, BK; Witbeck, T1
Anderson, DK; Zuccarello, M1
Anderson, DK; Marsch, JT; Schmitt, G; Woodward, J; Zuccarello, M1
Hongo, K; Kassell, NF; Ogawa, H; Tsukahara, T; Vollmer, DG1
Hall, ED; Travis, MA1

Reviews

14 review(s) available for u 74006f and Subarachnoid Hemorrhage

ArticleYear
Clinical outcome prediction in aneurysmal subarachnoid hemorrhage using Bayesian neural networks with fuzzy logic inferences.
    Computational and mathematical methods in medicine, 2013, Volume: 2013

    Topics: Aneurysm, Ruptured; Bayes Theorem; Computational Biology; Decision Support Techniques; Fuzzy Logic; Humans; Linear Models; Neural Networks, Computer; Neuroprotective Agents; Pregnatrienes; Prognosis; Subarachnoid Hemorrhage; Treatment Outcome

2013
Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage.
    Neurocritical care, 2009, Volume: 10, Issue:1

    Topics: Cerebral Infarction; Humans; Intracranial Aneurysm; Neuroprotective Agents; Pregnatrienes; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracranial

2009
Tirilazad for aneurysmal subarachnoid haemorrhage.
    The Cochrane database of systematic reviews, 2010, Feb-17, Issue:2

    Topics: Brain Ischemia; Humans; Neuroprotective Agents; Nimodipine; Pregnatrienes; Randomized Controlled Trials as Topic; Subarachnoid Hemorrhage; Treatment Outcome

2010
Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage.
    Critical care (London, England), 2007, Volume: 11, Issue:4

    Topics: Angioplasty, Balloon; Calcium Channel Blockers; Cerebral Angiography; Endothelin-1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuroprotective Agents; Nimodipine; Nitric Oxide Donors; Pregnatrienes; Subarachnoid Hemorrhage; Thrombolytic Therapy; Ultrasonography, Doppler, Transcranial; Vasodilator Agents; Vasospasm, Intracranial

2007
21-Aminosteroids ("lazaroids").
    Advances in experimental medicine and biology, 1994, Volume: 366

    Topics: Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Free Radical Scavengers; Humans; Lipid Peroxides; Male; Pregnatrienes; Randomized Controlled Trials as Topic; Subarachnoid Hemorrhage

1994
Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage.
    Advances in pharmacology (San Diego, Calif.), 1994, Volume: 28

    Topics: Animals; Antioxidants; Brain; Brain Injuries; Brain Ischemia; Humans; Lipid Peroxidation; Lipid Peroxides; Methylprednisolone; Pregnatrienes; Spinal Cord Injuries; Subarachnoid Hemorrhage

1994
Efficacy and mechanisms of action of the cytoprotective lipid peroxidation inhibitor tirilazad mesylate in subarachnoid haemorrhage.
    European journal of anaesthesiology, 1996, Volume: 13, Issue:3

    Topics: Animals; Humans; Lipid Peroxidation; Neuroprotective Agents; Pregnatrienes; Subarachnoid Hemorrhage

1996
[Pharmacological treatment of vasospasm in subarachnoid hemorrhage].
    Annales francaises d'anesthesie et de reanimation, 1996, Volume: 15, Issue:3

    Topics: Antioxidants; Humans; Ischemic Attack, Transient; Lipid Peroxides; Male; Nicardipine; Nimodipine; Papaverine; Plasminogen Activators; Pregnatrienes; Subarachnoid Hemorrhage; Tissue Plasminogen Activator; Vasodilator Agents

1996
[Indications for steroid and tirilazad treatment in patients with subarachnoid hemorrhage].
    Minerva anestesiologica, 1998, Volume: 64, Issue:5

    Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Humans; Pregnatrienes; Subarachnoid Hemorrhage

1998
The effect and management of delayed vasospasm after aneurysmal subarachnoid hemorrhage.
    Neurologia medico-chirurgica, 1998, Volume: 38 Suppl

    Topics: Aneurysm, Ruptured; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Humans; Ischemic Attack, Transient; Male; Neuroprotective Agents; Nimodipine; Pregnatrienes; Sex Factors; Subarachnoid Hemorrhage; Time Factors

1998
Metaanalysis of trials of tirilazad mesylate in aneurysmal SAH.
    Acta neurochirurgica. Supplement, 2001, Volume: 77

    Topics: Adult; Female; Humans; Intracranial Aneurysm; Male; Multicenter Studies as Topic; Neuroprotective Agents; Pregnatrienes; Randomized Controlled Trials as Topic; Subarachnoid Hemorrhage; Treatment Outcome

2001
Lazaroids: efficacy and mechanism of action of the 21-aminosteroids in neuroprotection.
    British journal of anaesthesia, 2001, Volume: 86, Issue:1

    Topics: Antioxidants; Brain Injuries; Brain Ischemia; Free Radical Scavengers; Humans; Lipid Peroxidation; Neuroprotective Agents; Pregnatrienes; Subarachnoid Hemorrhage

2001
[Cerebral vasospasm after subarachnoid hemorrhage. Current possibilities of prevention and treatment].
    Przeglad lekarski, 2002, Volume: 59, Issue:1

    Topics: Aneurysm, Ruptured; Humans; Neuroprotective Agents; Nimodipine; Pregnatrienes; Subarachnoid Hemorrhage; Tissue Plasminogen Activator; Vasodilator Agents; Vasospasm, Intracranial

2002
Beneficial effects of the 21-aminosteroid U74006F in acute CNS trauma and hypovolemic shock.
    Acta anaesthesiologica Belgica, 1987, Volume: 38, Issue:4

    Topics: Animals; Brain Injuries; Lipid Peroxides; Pregnatrienes; Shock; Spinal Cord Injuries; Subarachnoid Hemorrhage

1987

Trials

17 trial(s) available for u 74006f and Subarachnoid Hemorrhage

ArticleYear
National socioeconomic indicators are associated with outcomes after aneurysmal subarachnoid hemorrhage: a hierarchical mixed-effects analysis.
    Journal of neurosurgery, 2014, Volume: 121, Issue:5

    Topics: Algorithms; Aneurysm, Ruptured; Data Interpretation, Statistical; Female; Glasgow Outcome Scale; Gross Domestic Product; Humans; Male; Middle Aged; Neuroprotective Agents; Neurosurgery; Pregnatrienes; Socioeconomic Factors; Subarachnoid Hemorrhage; Treatment Outcome

2014
Factors associated with the development of vasospasm after planned surgical treatment of aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2003, Volume: 99, Issue:4

    Topics: Adult; Aged; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neuroprotective Agents; Neurosurgical Procedures; Nimodipine; Postoperative Complications; Pregnatrienes; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2003
Grading of subarachnoid hemorrhage: modification of the world World Federation of Neurosurgical Societies scale on the basis of data for a large series of patients.
    Neurosurgery, 2004, Volume: 54, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Combined Modality Therapy; Databases as Topic; Diagnostic Imaging; Double-Blind Method; Female; Glasgow Outcome Scale; Humans; Intracranial Aneurysm; Male; Middle Aged; Neuroprotective Agents; Neurosurgery; Outcome Assessment, Health Care; Postoperative Complications; Pregnatrienes; Prognosis; Prospective Studies; Risk Factors; Societies, Medical; Subarachnoid Hemorrhage

2004
Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage.
    Neurosurgery, 2007, Volume: 60, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cerebral Infarction; Comorbidity; Double-Blind Method; Humans; Incidence; Internationality; Male; Middle Aged; Neuroprotective Agents; Outcome Assessment, Health Care; Placebo Effect; Pregnatrienes; Risk Assessment; Risk Factors; Subarachnoid Hemorrhage; Treatment Outcome

2007
Outcome in patients with subarachnoid hemorrhage treated with antiepileptic drugs.
    Journal of neurosurgery, 2007, Volume: 107, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Double-Blind Method; Female; Follow-Up Studies; Glasgow Outcome Scale; Humans; Male; Middle Aged; Practice Patterns, Physicians'; Pregnatrienes; Seizures; Subarachnoid Hemorrhage; Treatment Outcome

2007
Intraventricular hemorrhage from ruptured aneurysm: clinical characteristics, complications, and outcomes in a large, prospective, multicenter study population.
    Journal of neurosurgery, 2007, Volume: 107, Issue:2

    Topics: Adult; Aged; Aneurysm, Ruptured; Cerebral Hemorrhage; Cohort Studies; Double-Blind Method; Female; Glasgow Outcome Scale; Humans; Intracranial Aneurysm; Male; Middle Aged; Neuroprotective Agents; Pregnatrienes; Prognosis; Subarachnoid Hemorrhage

2007
Phase II trial of tirilazad in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study.
    Journal of neurosurgery, 1995, Volume: 82, Issue:5

    Topics: Adult; Aged; Analysis of Variance; Chi-Square Distribution; Double-Blind Method; Female; Follow-Up Studies; Free Radical Scavengers; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Lipid Peroxides; Male; Middle Aged; Pregnatrienes; Subarachnoid Hemorrhage

1995
Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand.
    Journal of neurosurgery, 1996, Volume: 84, Issue:2

    Topics: Adult; Antioxidants; Double-Blind Method; Female; Free Radical Scavengers; Humans; Intracranial Aneurysm; Male; Middle Aged; Pharmaceutical Vehicles; Pregnatrienes; Prospective Studies; Subarachnoid Hemorrhage; Survival Analysis; Treatment Outcome

1996
A randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in North America.
    Journal of neurosurgery, 1997, Volume: 86, Issue:3

    Topics: Administration, Oral; Anticonvulsants; Calcium Channel Blockers; Cerebral Angiography; Clinical Protocols; Double-Blind Method; Employment; Female; Follow-Up Studies; Glasgow Coma Scale; Humans; Injections, Intravenous; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle Aged; Neuroprotective Agents; Nimodipine; North America; Patient Admission; Pharmaceutical Vehicles; Placebos; Pregnatrienes; Prospective Studies; Safety; Sex Factors; Subarachnoid Hemorrhage; Survival Rate; Treatment Outcome

1997
Economic analysis of tirilazad mesylate for aneurysmal subarachnoid hemorrhage. Economic evaluation of a phase III clinical trial in Europe and Australia.
    International journal of technology assessment in health care, 1998,Winter, Volume: 14, Issue:1

    Topics: Australia; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Europe; Female; Hospital Costs; Hospitals; Humans; Intracranial Aneurysm; Male; Middle Aged; Neuroprotective Agents; New Zealand; Outcome Assessment, Health Care; Pregnatrienes; Sensitivity and Specificity; Subarachnoid Hemorrhage

1998
A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury.
    Journal of neurosurgery, 1998, Volume: 89, Issue:4

    Topics: Adult; Brain Injuries; Cohort Studies; Craniocerebral Trauma; Female; Follow-Up Studies; Glasgow Coma Scale; Hematoma, Epidural, Cranial; Humans; Hypotension; Hypoxia; Male; Neuroprotective Agents; Placebos; Pregnatrienes; Prognosis; Prospective Studies; Risk Factors; Sex Factors; Subarachnoid Hemorrhage; Survival Rate; Treatment Outcome

1998
Too little, too late: does tirilazad mesylate reduce fatigue after subarachnoid hemorrhage?
    Neurosurgery, 1998, Volume: 43, Issue:4

    Topics: Adult; Double-Blind Method; Fatigue; Female; Glasgow Coma Scale; Humans; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; New Zealand; Pregnatrienes; Sick Role; Subarachnoid Hemorrhage; Treatment Outcome

1998
[Indications for steroid and tirilazad treatment in patients with subarachnoid hemorrhage].
    Minerva anestesiologica, 1998, Volume: 64, Issue:5

    Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Humans; Pregnatrienes; Subarachnoid Hemorrhage

1998
Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part I. A cooperative study in Europe, Australia, New Zealand, and South Africa.
    Journal of neurosurgery, 1999, Volume: 90, Issue:6

    Topics: Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Incidence; International Cooperation; Intracranial Aneurysm; Ischemic Attack, Transient; Middle Aged; Nervous System; Neuroprotective Agents; Pharmaceutical Vehicles; Pregnatrienes; Prospective Studies; Subarachnoid Hemorrhage; Time Factors; Treatment Outcome

1999
Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part II. A cooperative study in North America.
    Journal of neurosurgery, 1999, Volume: 90, Issue:6

    Topics: Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Incidence; Intracranial Aneurysm; Ischemic Attack, Transient; Middle Aged; Nervous System; Neuroprotective Agents; Pharmaceutical Vehicles; Pregnatrienes; Prospective Studies; Subarachnoid Hemorrhage; Time Factors; Treatment Outcome

1999
Efficacy of transluminal angioplasty for the management of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2000, Volume: 92, Issue:2

    Topics: Adult; Aged; Angioplasty, Balloon; Combined Modality Therapy; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Intracranial Aneurysm; Male; Middle Aged; Neuroprotective Agents; Papaverine; Pregnatrienes; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilator Agents; Vasospasm, Intracranial

2000
Tirilazad and subarachnoid hemorrhage.
    Journal of neurosurgery, 2000, Volume: 92, Issue:3

    Topics: Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Intracranial Aneurysm; Neuroprotective Agents; Pregnatrienes; Subarachnoid Hemorrhage; Survival Rate

2000

Other Studies

27 other study(ies) available for u 74006f and Subarachnoid Hemorrhage

ArticleYear
Pharmacologic Management of Subarachnoid Hemorrhage.
    World neurosurgery, 2015, Volume: 84, Issue:1

    Topics: Adrenal Cortex Hormones; Animals; Anticoagulants; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Clinical Trials as Topic; Dexamethasone; Dioxanes; Disease Models, Animal; Drugs, Chinese Herbal; Estrogens; Evidence-Based Medicine; Free Radical Scavengers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnesium Sulfate; Neuroprotective Agents; Nimodipine; Platelet Aggregation Inhibitors; Pregnatrienes; Progesterone; Pyridines; Pyrimidines; Receptor, Endothelin A; Subarachnoid Hemorrhage; Sulfonamides; Tetrazoles

2015
Is it time to resurrect "lazaroids"?
    Journal of neuroscience research, 2017, 01-02, Volume: 95, Issue:1-2

    Topics: Brain Hemorrhage, Traumatic; Brain Injuries, Traumatic; Female; Free Radical Scavengers; Humans; Male; Neuroprotective Agents; Pregnatrienes; Sex Characteristics; Stroke; Subarachnoid Hemorrhage

2017
Effect of country or continent of treatment on outcome after aneurysmal subarachnoid hemorrhage. Clinical article.
    Journal of neurosurgery, 2009, Volume: 111, Issue:1

    Topics: Adolescent; Adult; Africa; Australia; Child; Child, Preschool; Combined Modality Therapy; Europe; Humans; Infant; Logistic Models; Middle Aged; Multivariate Analysis; Neuroprotective Agents; North America; Oceania; Pregnatrienes; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Subarachnoid Hemorrhage

2009
Sample size estimates for clinical trials of vasospasm in subarachnoid hemorrhage.
    Stroke, 2009, Volume: 40, Issue:7

    Topics: Adult; Aged; Clinical Trials as Topic; Humans; Middle Aged; Neuroprotective Agents; Outcome Assessment, Health Care; Pregnatrienes; Sample Size; Sensitivity and Specificity; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2009
Sliding dichotomy compared with fixed dichotomization of ordinal outcome scales in subarachnoid hemorrhage trials.
    Journal of neurosurgery, 2013, Volume: 118, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Pregnatrienes; Randomized Controlled Trials as Topic; Statistics as Topic; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracranial

2013
Racial differences in demographics, acute complications, and outcomes in patients with subarachnoid hemorrhage: a large patient series.
    Journal of neurosurgery, 2005, Volume: 103, Issue:1

    Topics: Adult; Aged; Black or African American; Double-Blind Method; Female; Humans; Male; Middle Aged; Minority Groups; Neuroprotective Agents; Patient Admission; Pregnatrienes; Randomized Controlled Trials as Topic; Retrospective Studies; Subarachnoid Hemorrhage; Treatment Outcome; White People

2005
Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale.
    Neurosurgery, 2006, Volume: 59, Issue:1

    Topics: Humans; Neuroprotective Agents; Predictive Value of Tests; Pregnatrienes; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Vasospasm, Intracranial

2006
Re: Grading of subarachnoid hemorrhage: modification of the World Federation of Neurosurgical Societies scale on the basis of data for a large series of patients.
    Neurosurgery, 2005, Volume: 56, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Combined Modality Therapy; Databases as Topic; Diagnostic Imaging; Double-Blind Method; Female; Glasgow Outcome Scale; Humans; Intracranial Aneurysm; Male; Middle Aged; Neuroprotective Agents; Neurosurgery; Outcome Assessment, Health Care; Postoperative Complications; Pregnatrienes; Prognosis; Prospective Studies; Risk Factors; Societies, Medical; Subarachnoid Hemorrhage

2005
Multiple-dose tolerability and pharmacokinetics of tirilazad mesylate at doses of up to 10 mg/kg/day administered over 5-10 days in healthy volunteers.
    International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:5

    Topics: Adult; Chromatography, High Pressure Liquid; Craniocerebral Trauma; Drug Tolerance; Half-Life; Humans; Infusions, Intravenous; Lipid Peroxides; Male; Middle Aged; Pregnatrienes; Subarachnoid Hemorrhage

1994
Effects of new 21-aminosteroid tirilazad mesylate (U74006F) on chronic cerebral vasospasm in a "two-hemorrhage" model of beagle dogs.
    Neurosurgery, 1994, Volume: 34, Issue:6

    Topics: Animals; Cerebral Angiography; Chronic Disease; Dogs; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Free Radicals; Infusions, Intravenous; Ischemic Attack, Transient; Lipid Peroxidation; Lipid Peroxides; Male; Pregnatrienes; Subarachnoid Hemorrhage

1994
New developments in the treatment of SAH-induced cerebral vasospasm.
    Axone (Dartmouth, N.S.), 1993, Volume: 15, Issue:1

    Topics: Humans; Ischemic Attack, Transient; Lipid Peroxides; Nimodipine; Pregnatrienes; Subarachnoid Hemorrhage

1993
Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury.
    Journal of neurosurgery, 1996, Volume: 84, Issue:2

    Topics: Animals; Antioxidants; Blood-Brain Barrier; Cells, Cultured; Lipid Peroxides; Male; Mice; Mice, Inbred Strains; Neurons; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Sprague-Dawley; Spinal Cord; Subarachnoid Hemorrhage

1996
[Pharmacological therapeutic prospects of cerebral vasospasm].
    Annales francaises d'anesthesie et de reanimation, 1996, Volume: 15, Issue:3

    Topics: Antioxidants; Fibrinolysis; Humans; Injections, Intraventricular; Ischemic Attack, Transient; Lipid Peroxides; Oxyhemoglobins; Plasminogen Activators; Pregnatrienes; Subarachnoid Hemorrhage; Superoxide Dismutase

1996
Tirilazad and subarachnoid hemorrhage.
    Journal of neurosurgery, 1996, Volume: 84, Issue:6

    Topics: Antioxidants; Humans; Pregnatrienes; Subarachnoid Hemorrhage

1996
Pharmacology of the aminosteroids in brain diseases.
    Methods and findings in experimental and clinical pharmacology, 1996, Volume: 18 Suppl B

    Topics: Brain Injuries; Free Radical Scavengers; Humans; Lipid Peroxidation; Pregnatrienes; Spinal Cord Injuries; Subarachnoid Hemorrhage

1996
Inhibition of nitric oxide generation and lipid peroxidation attenuates hemolysate-induced injury to cerebrovascular endothelium.
    Acta neurochirurgica, 1997, Volume: 139, Issue:3

    Topics: Animals; Antioxidants; Brain; Cattle; Cell Membrane Permeability; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Free Radicals; Guanidines; Lipid Peroxidation; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pregnatrienes; Rabbits; Reactive Oxygen Species; Subarachnoid Hemorrhage

1997
Comparison of the use of medical resources and outcomes in the treatment of aneurysmal subarachnoid hemorrhage between Canada and the United States.
    Stroke, 1998, Volume: 29, Issue:2

    Topics: Canada; Confidence Intervals; Female; Health Resources; Humans; Intracranial Aneurysm; Male; Middle Aged; Multicenter Studies as Topic; Neuroprotective Agents; Pregnatrienes; Randomized Controlled Trials as Topic; Severity of Illness Index; Subarachnoid Hemorrhage; Survival Rate; Treatment Outcome; United States

1998
Estimating country-specific cost-effectiveness from multinational clinical trials.
    Health economics, 1998, Volume: 7, Issue:6

    Topics: Clinical Trials as Topic; Cost-Benefit Analysis; Cross-Cultural Comparison; Data Interpretation, Statistical; Female; Hospital Costs; Humans; Linear Models; Male; Models, Econometric; Mortality; Multicenter Studies as Topic; Neuroprotective Agents; Outcome and Process Assessment, Health Care; Pregnatrienes; Regression Analysis; Subarachnoid Hemorrhage; Technology Assessment, Biomedical; Value of Life

1998
Effects of tirilazad mesylate on vasospasm and phospholipid hydroperoxides in a primate model of subarachnoid hemorrhage.
    Stroke, 1999, Volume: 30, Issue:2

    Topics: Animals; Cerebral Angiography; Cerebral Arteries; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Injections, Intravenous; Ischemic Attack, Transient; Lipid Peroxidation; Luminescent Measurements; Macaca fascicularis; Male; Neuroprotective Agents; Phosphatidylcholines; Phosphatidylethanolamines; Pregnatrienes; Subarachnoid Hemorrhage; Vasoconstriction

1999
Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage.
    Pharmaceutical research, 1999, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antioxidants; Body Weight; Drug Interactions; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Models, Biological; Multivariate Analysis; Phenytoin; Pregnatrienes; Sex Factors; Subarachnoid Hemorrhage

1999
Factors associated with hydrocephalus after aneurysmal subarachnoid hemorrhage.
    Neurosurgery, 1999, Volume: 45, Issue:5

    Topics: Adult; Aged; Brain; Cerebral Ventriculography; Cerebrospinal Fluid Shunts; Female; Follow-Up Studies; Glasgow Coma Scale; Humans; Hydrocephalus; Intracranial Aneurysm; Male; Middle Aged; Neuroprotective Agents; Postoperative Complications; Pregnatrienes; Retrospective Studies; Risk Factors; Sex Factors; Subarachnoid Hemorrhage

1999
Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats.
    Stroke, 1991, Volume: 22, Issue:2

    Topics: Animals; Dinoprostone; Eicosanoids; Epoprostenol; Lipid Peroxides; Lipoxygenase; Male; Methylprednisolone; Pregnatrienes; Prostaglandin D2; Rats; Rats, Inbred Strains; Subarachnoid Hemorrhage

1991
Effect of 21-aminosteroid U-74006F on lipid peroxidation in subarachnoid clot.
    Journal of neurosurgery, 1991, Volume: 74, Issue:3

    Topics: Animals; Cerebral Arteries; Lipid Peroxidation; Lipid Peroxides; Macaca fascicularis; Malondialdehyde; Placebos; Pregnatrienes; Subarachnoid Hemorrhage

1991
Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats.
    Stroke, 1989, Volume: 20, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood-Brain Barrier; Brain; Capillary Permeability; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Ferrous Compounds; Male; Pregnatrienes; Rats; Rats, Inbred Strains; Serum Albumin; Subarachnoid Hemorrhage

1989
Effect of the 21-aminosteroid U-74006F on cerebral vasospasm following subarachnoid hemorrhage.
    Journal of neurosurgery, 1989, Volume: 71, Issue:1

    Topics: Animals; Cerebral Angiography; Cerebrovascular Circulation; Ischemic Attack, Transient; Lipid Peroxides; Male; Pregnatrienes; Rabbits; Subarachnoid Hemorrhage; Subtraction Technique

1989
Effect of the nonglucocorticoid 21-aminosteroid U74006F experimental cerebral vasospasm.
    Surgical neurology, 1989, Volume: 31, Issue:3

    Topics: Animals; Basilar Artery; Ischemic Attack, Transient; Lipid Peroxides; Male; Pregnatrienes; Rabbits; Subarachnoid Hemorrhage; Vasoconstriction

1989
Effects of the nonglucocorticoid 21-aminosteroid U74006F on acute cerebral hypoperfusion following experimental subarachnoid hemorrhage.
    Experimental neurology, 1988, Volume: 102, Issue:2

    Topics: Animals; Blood Pressure; Cats; Caudate Nucleus; Cerebrovascular Circulation; Female; Pregnatrienes; Regional Blood Flow; Subarachnoid Hemorrhage; Vascular Resistance

1988
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