u 74006f has been researched along with Brain Ischemia in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.38) | 18.7374 |
| 1990's | 34 (72.34) | 18.2507 |
| 2000's | 7 (14.89) | 29.6817 |
| 2010's | 3 (6.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Budohoski, KP; Bulters, DO; Helmy, A; Karri, SK; Kirkpatrick, PJ; Kirollos, RW; Ogilvy, CS; Trivedi, RA; Young, AM | 1 |
| Liu, M; Wang, L; Wu, B; Zhang, S | 1 |
| Arba, F; Balami, JS; Buchan, AM; Kleinschnitz, C; Minnerup, J; Sutherland, BA | 1 |
| Ashwood, T; Green, AR | 1 |
| Johnston, KC; Wagner, DP | 1 |
| Abad-Hernández, MM; Broseta-Rodrigo, J; García-March, G; Gonçalves-Estella, JM; Sánchez-Casado, M; Sánchez-Ledesma, MJ | 1 |
| Blizzard, KK; Kirsch, JR; Koehler, RC; Maruki, Y; Traystman, RJ | 2 |
| Andrus, PK; Hall, ED; Sun, FF; Taylor, BM | 1 |
| Grögaard, B; Karlsson, BR; Löberg, EM; Steen, PA | 1 |
| Clark, WM; Coull, BM; Hotan, T; Lauten, JD | 1 |
| Hall, ED; Park, CK | 1 |
| Hall, ED; McCall, JM; Means, ED | 1 |
| Mizuno, A; Nakashima, M; Uematsu, T; Umemura, K; Wada, K | 1 |
| Althaus, JS; Andrus, PK; Cazers, AR; Hall, ED; VonVoigtlander, PF; Williams, CM | 1 |
| Hall, ED | 3 |
| Chopp, M; Lee, SA; Schultz, LR; Vande Linde, AM; Welch, KM | 1 |
| Haas, N; Peeling, J; Sutherland, G | 1 |
| Giacoia, GP | 1 |
| Hall, ED; Hurn, PD; Kim, H; Koehler, RC; Traystman, RJ | 1 |
| Boisvert, DP; Hall, ED | 1 |
| Janata, K; Kürkciyan, I; Malzer, R; Müllner, M; Schreiber, W; Sterz, F | 1 |
| Andrus, PK; Ayer, DE; Banitt, LS; Belonga, KL; Bundy, GL; Hall, ED; Lutzke, BS; Oostveen, JA; Palmer, JR; Raub, TJ; Sawada, GA; Scherch, HM; Smith, SL; Tustin, JS | 1 |
| Andiné, P; Bågenholm, R; Hagberg, H | 1 |
| Fleishaker, JC; Peters, GR | 1 |
| Hall, ED; Jolly, RA; Oostveen, JA; Petry, TW; Satoh, PS; Williams, LR | 1 |
| Burmester, GR; Buttgereit, F; Hiepe, F | 1 |
| Adams, RJ; Faught, RE; Feasby, TE; Haley, EC; Hanson, SK; Johnston, KC; Li, JY; Lyden, PD | 1 |
| Haley, EC; Homer, D; Johnston, KC; Koroshetz, W; Saver, JL; Truskowski, LL; Wityk, R | 1 |
| Baethmann, A; Hungerhuber, E; Reulen, HJ; Schmid-Elsaesser, R; Zausinger, S | 1 |
| Akdemir, H; Koç, RK; Kontaş, O; Kurtsoy, A; Menkü, A; Oktem, IS | 1 |
| Alessandri, B; Basciani, R; Gratz, O; Landolt, H; Langemann, H; Lyrer, P; Pluess, D | 1 |
| Kam, PC; Kavanagh, RJ | 1 |
| Algra, A; Bär, PR; Bath, PM; Kappelle, LJ; Orgogozo, JM; Ringelstein, EB; van der Worp, HB; van Gijn, J | 1 |
| Blizzard, KK; Helfaer, MA; Hurn, PD; Kirsch, JR; Koehler, RC; Traystman, RJ | 1 |
| Hall, ED; Sato, PH | 1 |
| Buchan, AM; Slivka, A; Xue, D | 1 |
| Butler, K; Lesiuk, H; Peeling, J; Saunders, J; Sutherland, G | 1 |
| Michenfelder, JD; Milde, JH; Milde, LN; Perkins, WJ | 1 |
| Grønås, T; Haraldseth, O; Unsgård, G | 1 |
| Braughler, JM; Hall, ED; Jacobsen, EJ; Linseman, KL; Pazara, KE | 1 |
| Hall, ED; Yonkers, PA | 1 |
| DeCrescito, V; Wojak, JC; Young, W | 1 |
| Braughler, JM; Hall, ED; Pazara, KE | 1 |
10 review(s) available for u 74006f and Brain Ischemia
| Article | Year |
|---|---|
Tirilazad for aneurysmal subarachnoid haemorrhage.
Topics: Brain Ischemia; Humans; Neuroprotective Agents; Nimodipine; Pregnatrienes; Randomized Controlled Trials as Topic; Subarachnoid Hemorrhage; Treatment Outcome | 2010 |
Neuroprotection for ischaemic stroke: translation from the bench to the bedside.
Topics: Acute Disease; Animals; Benzenesulfonates; Brain Ischemia; Chelating Agents; Clinical Trials as Topic; Combined Modality Therapy; Diffusion of Innovation; Disease Models, Animal; Drug Evaluation, Preclinical; Egtazic Acid; Hematopoietic Cell Growth Factors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypothermia, Induced; Magnesium; Minocycline; NADPH Oxidases; Neuroprotective Agents; Pregnatrienes; Serum Albumin; Stroke; Thrombolytic Therapy; Translational Research, Biomedical | 2012 |
Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.
Topics: Animals; Antioxidants; Antipyrine; Azoles; Benzenesulfonates; Brain Ischemia; Edaravone; Free Radical Scavengers; Humans; Isoindoles; Mice; Mice, Mutant Strains; Neuroprotective Agents; Nitrogen Oxides; Organoselenium Compounds; Pregnatrienes; Rats; Reactive Oxygen Species; Stroke; Treatment Failure; Treatment Outcome | 2005 |
Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Brain Ischemia; Humans; Lipid Peroxidation; Lipid Peroxides; Methylprednisolone; Pregnatrienes; Spinal Cord Injuries; Subarachnoid Hemorrhage | 1994 |
Cerebral ischaemia, free radicals and antioxidant protection.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Ischemic Attack, Transient; Lipid Peroxides; Pregnatrienes; Rats | 1993 |
Possibilities of brain protection with tirilazad after cardiac arrest.
Topics: Antioxidants; Brain Ischemia; Cardiopulmonary Resuscitation; Free Radical Scavengers; Heart Arrest; Humans; Neuroprotective Agents; Pregnatrienes | 1996 |
Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Free Radical Scavengers; Gerbillinae; Lipid Peroxidation; Male; Mice; Microcirculation; Neuroprotective Agents; Pregnatrienes; Rats; Structure-Activity Relationship | 1996 |
Inhibition of lipid peroxidation in central nervous system trauma and ischemia.
Topics: Animals; Antioxidants; Brain Injuries; Brain Ischemia; Humans; Lipid Peroxidation; Pregnatrienes | 1995 |
[The therapeutic potential of lazaroids (21-aminosteroids). A recent survey].
Topics: Animals; Antioxidants; Brain Injuries; Brain Ischemia; Cell Membrane; Free Radical Scavengers; Free Radicals; Glucocorticoids; Humans; Ischemia; Lipid Peroxidation; Neuroprotective Agents; Pregnatrienes; Reperfusion Injury; Rheumatic Diseases; Spinal Cord; Spinal Cord Injuries; Steroids | 1997 |
Lazaroids: efficacy and mechanism of action of the 21-aminosteroids in neuroprotection.
Topics: Antioxidants; Brain Injuries; Brain Ischemia; Free Radical Scavengers; Humans; Lipid Peroxidation; Neuroprotective Agents; Pregnatrienes; Subarachnoid Hemorrhage | 2001 |
6 trial(s) available for u 74006f and Brain Ischemia
| Article | Year |
|---|---|
Relationship between 3-month National Institutes of Health Stroke Scale score and dependence in ischemic stroke patients.
Topics: Activities of Daily Living; Age Factors; Aged; Brain Ischemia; Double-Blind Method; Ethnicity; Female; Glasgow Outcome Scale; Humans; Logistic Models; Male; Neuroprotective Agents; Pregnatrienes; ROC Curve; Sex Factors; Stroke; Survivors; Treatment Outcome | 2006 |
Safety study of tirilazad mesylate in patients with acute ischemic stroke (STIPAS).
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Lipid Peroxides; Male; Middle Aged; Pregnatrienes; Time Factors; Treatment Outcome | 1994 |
Pharmacokinetics of tirilazad and U-89678 in ischemic stroke patients receiving a loading regimen and maintenance regimen of 10 mg/kg/day of tirilazad.
Topics: Aged; Area Under Curve; Brain Ischemia; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neuroprotective Agents; Pregnatrienes | 1996 |
Medical and neurological complications of ischemic stroke: experience from the RANTTAS trial. RANTTAS Investigators.
Topics: Aged; Brain Ischemia; Cerebral Infarction; Databases as Topic; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Male; Neuroprotective Agents; Placebos; Pneumonia; Pregnatrienes; Regression Analysis; Severity of Illness Index | 1998 |
Infarct volume as a surrogate or auxiliary outcome measure in ischemic stroke clinical trials. The RANTTAS Investigators.
Topics: Acute Disease; Aged; Brain Ischemia; Cerebral Infarction; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Neuroprotective Agents; Pregnatrienes; Prognosis; Prospective Studies; Severity of Illness Index; Survival Rate; Tomography, X-Ray Computed | 1999 |
The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Cerebral Infarction; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Pregnatrienes; Single-Blind Method | 2002 |
31 other study(ies) available for u 74006f and Brain Ischemia
| Article | Year |
|---|---|
Pharmacologic Management of Subarachnoid Hemorrhage.
Topics: Adrenal Cortex Hormones; Animals; Anticoagulants; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Clinical Trials as Topic; Dexamethasone; Dioxanes; Disease Models, Animal; Drugs, Chinese Herbal; Estrogens; Evidence-Based Medicine; Free Radical Scavengers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnesium Sulfate; Neuroprotective Agents; Nimodipine; Platelet Aggregation Inhibitors; Pregnatrienes; Progesterone; Pyridines; Pyrimidines; Receptor, Endothelin A; Subarachnoid Hemorrhage; Sulfonamides; Tetrazoles | 2015 |
[Effect of combination therapy with hypothermia, magnesium and tirilazad in an experimental model of diffuse cerebral ischemia].
Topics: Animals; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Hypothermia, Induced; Magnesium; Male; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Wistar | 2007 |
Tirilazad pretreatment improves early cerebral metabolic and blood flow recovery from hyperglycemic ischemia.
Topics: Acidosis; Adenosine Triphosphate; Animals; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Dogs; Evoked Potentials; Hydrogen-Ion Concentration; Hyperglycemia; Magnetic Resonance Spectroscopy; Male; Microspheres; Phosphates; Pregnatrienes | 1995 |
Effects of the lipid peroxidation inhibitor tirilazad mesylate (U-74006F) on gerbil brain eicosanoid levels following ischemia and reperfusion.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Constriction; Eicosanoids; Gerbillinae; Leukotrienes; Lipid Peroxides; Male; Pregnatrienes; Prostaglandins; Reperfusion; Thromboxane B2 | 1994 |
The antioxidant tirilazad does not affect cerebral blood flow or histopathologic changes following severe ischemia in rats.
Topics: Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Carotid Stenosis; Cell Survival; Cerebral Infarction; Energy Metabolism; Free Radicals; Lipid Peroxides; Male; Oxygen Consumption; Pregnatrienes; Rats; Rats, Wistar | 1994 |
Therapeutic efficacy of tirilazad in experimental multiple cerebral emboli: a randomized, controlled trial.
Topics: Animals; Brain Ischemia; Cell Adhesion; Disease Models, Animal; Drug Evaluation, Preclinical; Free Radical Scavengers; Intracranial Embolism and Thrombosis; Lipid Peroxides; Male; Microspheres; Neutrophils; Pregnatrienes; Rabbits; Random Allocation | 1994 |
Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Dose-Response Relationship, Drug; Lipid Peroxides; Male; Nervous System; Pregnatrienes; Rats; Rats, Sprague-Dawley | 1994 |
Effect of 21-aminosteroid lipid peroxidation inhibitor, U74006F, in the rat middle cerebral artery occlusion model.
Topics: Animals; Arachidonic Acid; Brain Ischemia; Free Radical Scavengers; Lipid Peroxidation; Lipid Peroxides; Magnetic Resonance Imaging; Male; Pregnatrienes; Rats; Rats, Wistar; Reactive Oxygen Species; Thrombosis | 1994 |
The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury. Reversal by tirilazad mesylate (U-74006F).
Topics: Animals; Brain Injuries; Brain Ischemia; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Lipid Peroxides; Male; Mice; Pregnatrienes; Salicylates; Salicylic Acid | 1993 |
Post-ischemic brain tissue alkalosis suppressed by U74006F.
Topics: Alkalosis; Animals; Blood Gas Analysis; Blood Glucose; Brain; Brain Ischemia; Glucose; Hydrogen-Ion Concentration; Lipid Peroxidation; Lipid Peroxides; Magnetic Resonance Spectroscopy; Male; Pregnatrienes; Rats; Rats, Wistar | 1993 |
The role of oxygen radicals in traumatic injury: clinical implications.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Brain Ischemia; Cell Death; Disease Models, Animal; Free Radicals; Humans; Lipid Peroxidation; Lipid Peroxides; Mice; Pregnatrienes; Reactive Oxygen Species; Spinal Cord Injuries | 1993 |
Ischemic neocortical protection with U74006F--a dose-response curve.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Dose-Response Relationship, Drug; Lipid Peroxides; Male; Neurons; Pregnatrienes; Prosencephalon; Rats; Rats, Sprague-Dawley | 1993 |
Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia.
Topics: Acidosis; Adenosine Triphosphate; Animals; Bicarbonates; Brain; Brain Edema; Brain Ischemia; Cytoplasm; Dogs; Drug Evaluation, Preclinical; Evoked Potentials, Somatosensory; Hydrogen-Ion Concentration; Male; Phosphocreatine; Pregnatrienes; Reactive Oxygen Species; Reperfusion Injury | 1993 |
Asphyxial brain damage in the newborn: new insights into pathophysiology and possible pharmacologic interventions.
Topics: Asphyxia Neonatorum; Brain Ischemia; Calcium Channel Blockers; Dizocilpine Maleate; Free Radical Scavengers; Humans; Hypoxia, Brain; Infant, Newborn; Lipid Peroxides; Pregnatrienes; Reperfusion Injury | 1993 |
Amelioration of impaired cerebral metabolism after severe acidotic ischemia by tirilazad posttreatment in dogs.
Topics: Acidosis; Adenosine Triphosphate; Animals; Antioxidants; Brain; Brain Ischemia; Cerebrovascular Circulation; Dogs; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Hydrogen-Ion Concentration; Hyperemia; Hyperglycemia; Iron; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Oxygen Consumption; Phosphocreatine; Phosphorus; Pregnatrienes; Reperfusion | 1996 |
Tirilazad prevention of reperfusion edema after focal ischemia in cynomolgus monkeys.
Topics: Animals; Antioxidants; Brain Edema; Brain Ischemia; Female; Macaca fascicularis; Magnetic Resonance Imaging; Pregnatrienes; Reperfusion Injury | 1996 |
Effects of the 21-amino steroid tirilazad mesylate (U-74006F) on brain damage and edema after perinatal hypoxia-ischemia in the rat.
Topics: Animals; Antioxidants; Body Weight; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Disease Models, Animal; Drug Evaluation, Preclinical; Free Radical Scavengers; Hypoxia, Brain; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Inbred WF; Rats, Sprague-Dawley; Statistics as Topic | 1996 |
Cyclophosphamide is neuroprotective in a gerbil model of transient severe focal cerebral ischemia: correlation with effects of tirilazad mesylate (U-74006F).
Topics: Animals; Brain Ischemia; Cyclophosphamide; Disease Models, Animal; Gerbillinae; Male; Neuroprotective Agents; Pregnatrienes | 1996 |
Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia.
Topics: Animals; Basal Ganglia; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Drug Therapy, Combination; Electroencephalography; Hypothermia, Induced; Laser-Doppler Flowmetry; Magnesium Chloride; Male; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Sprague-Dawley; Weight Gain | 1999 |
Therapeutic effect of tirilazad mesylate (U-74006F), mannitol, and their combination on experimental ischemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Diuretics, Osmotic; Drug Therapy, Combination; Mannitol; Neuroprotective Agents; Photomicrography; Pregnatrienes; Rabbits; Random Allocation; Statistics, Nonparametric | 2000 |
Chronic effects of an aminosteroid on microdialytically measured parameters after experimental middle cerebral artery occlusion in the rat.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Drug Evaluation, Preclinical; Free Radicals; Glucose; Infarction, Middle Cerebral Artery; Lactic Acid; Male; Microdialysis; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Inbred SHR; Uric Acid | 2000 |
Tirilazad mesylate does not improve early cerebral metabolic recovery following compression ischemia in dogs.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dogs; Evoked Potentials, Somatosensory; Injections, Intraventricular; Magnetic Resonance Spectroscopy; Oxygen Consumption; Phosphates; Phosphocreatine; Pregnatrienes; Regional Blood Flow; Reperfusion Injury | 1992 |
Tirilazad mesylate protects vitamins C and E in brain ischemia-reperfusion injury.
Topics: Animals; Ascorbic Acid; Brain; Brain Chemistry; Brain Ischemia; Gerbillinae; Lipid Peroxides; Male; Pregnatrienes; Reperfusion Injury; Time Factors; Vitamin E | 1992 |
Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Ischemic Attack, Transient; Lipid Peroxides; Male; Pregnatrienes; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reperfusion | 1992 |
Effect of U74006F on forebrain ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Hippocampus; Lipid Peroxides; Magnetic Resonance Imaging; Male; Pregnatrienes; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Pretreatment with U74006F improves neurologic outcome following complete cerebral ischemia in dogs.
Topics: Animals; Blood Glucose; Brain Ischemia; Dogs; Electroencephalography; Female; Lipid Peroxides; Male; Nervous System; Osmolar Concentration; Pregnatrienes; Vitamin E | 1991 |
Quicker metabolic recovery after forebrain ischemia in rats treated with the antioxidant U74006F.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Free Radicals; Injections, Intravenous; Lipid Peroxides; Magnetic Resonance Spectroscopy; Male; Phosphates; Phosphocreatine; Pregnatrienes; Prosencephalon; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Nonsteroidal lazaroid U78517F in models of focal and global ischemia.
Topics: Animals; Brain Ischemia; Cell Survival; Chromans; Gerbillinae; Hippocampus; Lipid Peroxides; Male; Models, Biological; Neurons; Piperazines; Pregnatrienes | 1990 |
Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Pregnatrienes; Reference Values | 1988 |
21-Aminosteroid reduces ion shifts and edema in the rat middle cerebral artery occlusion model of regional ischemia.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Ischemia; Ions; Lipid Peroxides; Potassium; Pregnatrienes; Rats; Rats, Inbred Strains; Sodium | 1988 |
21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.
Topics: Animals; Brain Ischemia; Gerbillinae; Lipid Peroxides; Male; Pregnatrienes | 1988 |