u 74006f has been researched along with Brain Injuries in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 20 (71.43) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farace, E; Habbema, JD; Hukkelhoven, CW; Maas, AI; Marshall, LF; Steyerberg, EW | 1 |
| Bricolo, A; Lagarrigue, J; Lobato, R; Persson, L; Servadei, F | 1 |
| Farin, A; Marshall, LF | 1 |
| Gahm, C; Holmin, S; Mathiesen, T; Rudehill, S | 1 |
| Hilton, G | 1 |
| Hall, ED; McCall, JM; Means, ED | 1 |
| Hall, ED | 4 |
| Althaus, JS; Andrus, PK; Cazers, AR; Hall, ED; VonVoigtlander, PF; Williams, CM | 1 |
| Isayama, K; Nakamura, T; Nishimura, MC; Pitts, LH; Sanada, T | 1 |
| Clark, WM; Coull, BM; Hazel, JS | 1 |
| Bernstein, M; Cabantog, AM; Glen, J; Mikulis, D; Stiver, S | 1 |
| Andrus, PK; Ayer, DE; Banitt, LS; Belonga, KL; Bundy, GL; Hall, ED; Lutzke, BS; Oostveen, JA; Palmer, JR; Raub, TJ; Sawada, GA; Scherch, HM; Smith, SL; Tustin, JS | 1 |
| Bullock, R; Mathew, P; McCulloch, J; Teasdale, G | 1 |
| Jakobsen, M | 1 |
| Burmester, GR; Buttgereit, F; Hiepe, F | 1 |
| Deal, DD; Dewitt, DS; Prough, DS; Uchida, T; Vines, SM | 1 |
| Bullock, R; Choi, S; Newell, DW; Temkin, NR | 1 |
| Bricolo, A; Fearnside, M; Iannotti, F; Klauber, MR; Lagarrigue, J; Lobato, R; Maas, AI; Marshall, LF; Marshall, SB; Means, ED; Morris, GF; Musch, B; Persson, L; Pickard, JD; Piek, J; Servadei, F; Wellis, GN | 1 |
| Roberts, I | 1 |
| Burmester, GR; Buttgereit, F; Fici, G; Schmid, D; Tripmacher, R; von Voigtlander, P | 1 |
| Kam, PC; Kavanagh, RJ | 1 |
| Anderson, DK; Andrus, PK; Cox, JW; Hall, ED; Yonkers, PA | 1 |
| Banbury, M; McIntosh, TK; Smith, D; Thomas, M | 2 |
| Braughler, JM; Dimlich, RV; Hall, ED; Kindel, RM; McCall, JM; Tornheim, PA | 1 |
11 review(s) available for u 74006f and Brain Injuries
| Article | Year |
|---|---|
Secondary brain injury and the role of neuroprotective agents.
Topics: Brain Injuries; Humans; Lipid Peroxides; Pregnatrienes; Superoxide Dismutase | 1994 |
Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Brain Ischemia; Humans; Lipid Peroxidation; Lipid Peroxides; Methylprednisolone; Pregnatrienes; Spinal Cord Injuries; Subarachnoid Hemorrhage | 1994 |
Neuroprotective actions of glucocorticoid and nonglucocorticoid steroids in acute neuronal injury.
Topics: Animals; Brain Injuries; Glucocorticoids; Humans; Lipid Peroxides; Methylprednisolone; Motor Neurons; Nerve Degeneration; Neurons; Pregnatrienes; Spinal Cord Injuries; Steroids | 1993 |
Lazaroids. CNS pharmacology and current research.
Topics: Antioxidants; Brain Injuries; Cerebrovascular Disorders; Free Radical Scavengers; Humans; Lipid Peroxides; Pregnatrienes; Spinal Cord Injuries | 1995 |
Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Free Radical Scavengers; Gerbillinae; Lipid Peroxidation; Male; Mice; Microcirculation; Neuroprotective Agents; Pregnatrienes; Rats; Structure-Activity Relationship | 1996 |
Inhibition of lipid peroxidation in central nervous system trauma and ischemia.
Topics: Animals; Antioxidants; Brain Injuries; Brain Ischemia; Humans; Lipid Peroxidation; Pregnatrienes | 1995 |
[The therapeutic potential of lazaroids (21-aminosteroids). A recent survey].
Topics: Animals; Antioxidants; Brain Injuries; Brain Ischemia; Cell Membrane; Free Radical Scavengers; Free Radicals; Glucocorticoids; Humans; Ischemia; Lipid Peroxidation; Neuroprotective Agents; Pregnatrienes; Reperfusion Injury; Rheumatic Diseases; Spinal Cord; Spinal Cord Injuries; Steroids | 1997 |
Aminosteroids for acute traumatic brain injury.
Topics: Brain Injuries; Drug Evaluation; Humans; Neuroprotective Agents; Pregnatrienes; Randomized Controlled Trials as Topic | 2000 |
Lazaroids: efficacy and mechanism of action of the 21-aminosteroids in neuroprotection.
Topics: Antioxidants; Brain Injuries; Brain Ischemia; Free Radical Scavengers; Humans; Lipid Peroxidation; Neuroprotective Agents; Pregnatrienes; Subarachnoid Hemorrhage | 2001 |
Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury.
Topics: Animals; Antioxidants; Brain Injuries; Free Radical Scavengers; Humans; Lipid Peroxidation; Lipid Peroxides; Methylprednisolone; Pregnatrienes; Spinal Cord Injuries; Steroids; Vitamin E | 1992 |
Beneficial effects of the 21-aminosteroid U74006F in acute CNS trauma and hypovolemic shock.
Topics: Animals; Brain Injuries; Lipid Peroxides; Pregnatrienes; Shock; Spinal Cord Injuries; Subarachnoid Hemorrhage | 1987 |
1 trial(s) available for u 74006f and Brain Injuries
| Article | Year |
|---|---|
A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury.
Topics: Adult; Brain Injuries; Cohort Studies; Craniocerebral Trauma; Female; Follow-Up Studies; Glasgow Coma Scale; Hematoma, Epidural, Cranial; Humans; Hypotension; Hypoxia; Male; Neuroprotective Agents; Placebos; Pregnatrienes; Prognosis; Prospective Studies; Risk Factors; Sex Factors; Subarachnoid Hemorrhage; Survival Rate; Treatment Outcome | 1998 |
16 other study(ies) available for u 74006f and Brain Injuries
| Article | Year |
|---|---|
Regional differences in patient characteristics, case management, and outcomes in traumatic brain injury: experience from the tirilazad trials.
Topics: Adolescent; Adult; Aged; Brain Injuries; Canada; Case Management; Europe; Female; Glasgow Coma Scale; Humans; Male; Middle Aged; Neuroprotective Agents; Pregnatrienes; Randomized Controlled Trials as Topic; Referral and Consultation; Treatment Outcome; United States | 2002 |
Brain trauma.
Topics: Brain Injuries; Europe; Glasgow Coma Scale; Humans; Neuroprotective Agents; Pregnatrienes; Randomized Controlled Trials as Topic; Treatment Outcome; United States | 2003 |
Lessons from epidemiologic studies in clinical trials of traumatic brain injury.
Topics: Brain Injuries; Clinical Trials as Topic; Databases, Factual; Epidemiologic Methods; Humans; Medical Records Systems, Computerized; Neuroprotective Agents; Patient Selection; Pipecolic Acids; Pregnatrienes; Prognosis; Quality Assurance, Health Care; Risk Assessment; Risk Factors; Treatment Outcome; United States | 2004 |
Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain; Brain Injuries; Calcium Channel Blockers; Cell Survival; Colchicine; Dexamethasone; Disease Models, Animal; Encephalitis; Fluoresceins; Free Radical Scavengers; In Situ Nick-End Labeling; Male; Nerve Degeneration; Neuroprotective Agents; Nimodipine; Nitric Oxide; Nitric Oxide Synthase Type II; Organic Chemicals; Oxidative Stress; Pregnatrienes; Rats; Rats, Sprague-Dawley | 2005 |
The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury. Reversal by tirilazad mesylate (U-74006F).
Topics: Animals; Brain Injuries; Brain Ischemia; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Lipid Peroxides; Male; Mice; Pregnatrienes; Salicylates; Salicylic Acid | 1993 |
Effect of U74006F on neurologic function and brain edema after fluid percussion injury in rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Body Water; Brain Edema; Brain Injuries; Carbon Dioxide; Lipid Peroxides; Male; Motor Activity; Nervous System; Oxygen Consumption; Postural Balance; Pregnatrienes; Rats; Rats, Sprague-Dawley | 1993 |
The role of oxygen radicals in traumatic injury: clinical implications.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Brain Ischemia; Cell Death; Disease Models, Animal; Free Radicals; Humans; Lipid Peroxidation; Lipid Peroxides; Mice; Pregnatrienes; Reactive Oxygen Species; Spinal Cord Injuries | 1993 |
Tirilazad does not protect rat brain from brachytherapy-induced injury.
Topics: Animals; Antioxidants; Brachytherapy; Brain; Brain Injuries; Disease Models, Animal; Magnetic Resonance Imaging; Male; Pregnatrienes; Rats; Rats, Inbred F344; Time Factors | 1996 |
Changes in local microvascular permeability and in the effect of intervention with 21-aminosteroid (Tirilazad) in a new experimental model of focal cortical injury in the rat.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Injuries; Capillary Permeability; Cerebral Cortex; Cerebrovascular Circulation; Microcirculation; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Pharmacology of the aminosteroids in brain diseases.
Topics: Brain Injuries; Free Radical Scavengers; Humans; Lipid Peroxidation; Pregnatrienes; Spinal Cord Injuries; Subarachnoid Hemorrhage | 1996 |
Effects of nalmefene, CG3703, tirilazad, or dopamine on cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and hemorrhage.
Topics: Animals; Antioxidants; Blood Gas Analysis; Blood Pressure; Brain Injuries; Cats; Cerebral Hemorrhage; Cerebrovascular Circulation; Dopamine; Electroencephalography; Female; Hemoglobins; Male; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Oxygen Consumption; Pregnatrienes; Thyrotropin-Releasing Hormone | 1997 |
Corticosteroids in acute traumatic brain injury.
Topics: Adrenal Cortex Hormones; Brain Injuries; Humans; Neuroprotective Agents; Pregnatrienes; Randomized Controlled Trials as Topic; Treatment Outcome | 1998 |
Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells.
Topics: Adenosine Triphosphate; Anti-Inflammatory Agents; Brain Injuries; Calcium-Transporting ATPases; Cell Membrane; Cell Respiration; Concanavalin A; Dose-Response Relationship, Drug; Energy Metabolism; Enzyme Inhibitors; Humans; Leukocytes, Mononuclear; Lipid Peroxidation; Methylprednisolone; Neuroprotective Agents; Pregnatrienes; Protein Biosynthesis; Proteins; Pyrimidines; Pyrroles; Sodium-Potassium-Exchanging ATPase; Time Factors | 2001 |
The novel 21-aminosteroid U74006F attenuates cerebral edema and improves survival after brain injury in the rat.
Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Cations; Cerebral Cortex; Hippocampus; Lipid Peroxides; Male; Organ Size; Pregnatrienes; Rats; Thalamus | 1992 |
The novel 21-aminosteroid U-74006F attenuates cerebral oedema and improves survival after brain injury in the rat.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Lipid Peroxides; Male; Pregnatrienes; Rats; Rats, Inbred Strains; Survival Analysis | 1990 |
Effects of a 21-aminosteroid (U-74006F) on cerebral metabolites and edema after severe experimental head trauma.
Topics: Animals; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cats; Energy Metabolism; Female; Lipid Peroxidation; Organ Size; Pregnatrienes; Wounds, Nonpenetrating | 1990 |