u-104 has been researched along with Glaucoma* in 1 studies
1 other study(ies) available for u-104 and Glaucoma
| Article | Year |
|---|---|
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
We report a one-pot procedure for the synthesis of asymmetrical ureido-containing benzenesulfonamides based on in situ generation of the corresponding isocyanatobenezenesulfonamide species, which were trapped with the appropriate amines. A library of new compounds was generated and evaluated in vitro for their inhibition properties against a representative panel of the human (h) metalloenzymes carbonic anhydrases (EC 4.2.1.1), and the best performing compounds on the isozyme II (i.e., Topics: Animals; Benzenesulfonamides; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Drug Design; Glaucoma; Intraocular Pressure; Male; Models, Molecular; Protein Binding; Rabbits; Structure-Activity Relationship; Sulfonamides | 2022 |