u-0126 and Lymphoma--T-Cell

u-0126 has been researched along with Lymphoma--T-Cell* in 1 studies

Other Studies

1 other study(ies) available for u-0126 and Lymphoma--T-Cell

Article	Year
Modulatory effect of hydrogen peroxide on tumoral lymphocytes proliferation. Immunopharmacology and immunotoxicology, 2009, Volume: 31, Issue:1 BW 5147 (murine lymphoma cell line). We analyzed the effect of H2O2 in cell proliferation testing nitric oxide and apoptosis. Enzymes involved in the regulation of H2O2 levels as superoxide dismutase (SOD) and peroxidase (PER) were analyzed. H2O2 exerted a biphasic effect. The inhibitory effect of H2O2 was related to the activation of the ERK and P38 pathway, NO production and apoptosis. The high proliferation was associated with a low level of H2O2 related to a low SOD and a high PER activities. Drugs capable of producing an increase in H2O2 levels could be used in cancer. Topics: Animals; Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Hydrogen Peroxide; Imidazoles; Lymph Nodes; Lymphocytes; Lymphoma, T-Cell; Male; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase Kinases; Necrosis; NF-kappa B; Nitric Oxide; Nitriles; Nitrites; omega-N-Methylarginine; p38 Mitogen-Activated Protein Kinases; Peroxidase; Protein Kinase Inhibitors; Pyridines; Superoxide Dismutase; Superoxides	2009

Article

Year

Modulatory effect of hydrogen peroxide on tumoral lymphocytes proliferation.

Immunopharmacology and immunotoxicology, 2009, Volume: 31, Issue:1

BW 5147 (murine lymphoma cell line). We analyzed the effect of H2O2 in cell proliferation testing nitric oxide and apoptosis. Enzymes involved in the regulation of H2O2 levels as superoxide dismutase (SOD) and peroxidase (PER) were analyzed. H2O2 exerted a biphasic effect. The inhibitory effect of H2O2 was related to the activation of the ERK and P38 pathway, NO production and apoptosis. The high proliferation was associated with a low level of H2O2 related to a low SOD and a high PER activities. Drugs capable of producing an increase in H2O2 levels could be used in cancer.

Topics: Animals; Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Hydrogen Peroxide; Imidazoles; Lymph Nodes; Lymphocytes; Lymphoma, T-Cell; Male; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase Kinases; Necrosis; NF-kappa B; Nitric Oxide; Nitriles; Nitrites; omega-N-Methylarginine; p38 Mitogen-Activated Protein Kinases; Peroxidase; Protein Kinase Inhibitors; Pyridines; Superoxide Dismutase; Superoxides

2009