u-0126 has been researched along with Enterovirus-Infections* in 1 studies
1 other study(ies) available for u-0126 and Enterovirus-Infections
| Article | Year |
|---|---|
Regulation of enterovirus 2A protease-associated viral IRES activities by the cell's ERK signaling cascade: Implicating ERK as an efficiently antiviral target.
In a previous study the ERK1/2 pathway was found to be crucially involved in positive regulation of the enterovirus A 71(EV-A71) IRES (vIRES), thereby contributing to the efficient replication of an important human enterovirus causing death in young children (<5yrs) worldwide. This study focuses on unraveling more about the detailed mechanism of ERK's involvement in this regulation of vIRES. Through the use of siRNAs and specifically pharmacological inhibitor U0126, the ERK cascade was shown to positively regulate EV-A71-mediated cleavage of eIF4GI that established the cellular conditions which favour vIRES-dependent translation. Site-directed mutagenesis of the viral 2A protease (2A Topics: Antiviral Agents; Butadienes; Cell Line, Tumor; Enterovirus A, Human; Enterovirus Infections; Enzyme Activation; HEK293 Cells; Humans; Internal Ribosome Entry Sites; Mutagenesis, Site-Directed; Nitriles; Polyproteins; Rhabdomyosarcoma; RNA, Small Interfering; Signal Transduction; Viral Proteins; Virus Replication | 2017 |