tyrphostin ag957 has been researched along with Granulocytic Leukemia, Chronic in 8 studies
tyrphostin AG957: tyrosine kinase blocker; structure given in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adaphostin (NSC 680410), an analog of the tyrphostin AG957, was previously shown to induce Bcr/abl down-regulation followed by loss of clonogenic survival in chronic myelogenous leukemia (CML) cell lines and clinical samples." | 3.72 | Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. ( Adjei, AA; Bone, N; Bruzek, LM; Chandra, J; Hackbarth, J; Karp, JE; Kaufmann, SH; Kay, NE; Le, S; Loegering, D; Narayanan, VL; Sausville, EA; Tefferi, A, 2003) |
| "The K562 cell line derived from a chronic myelogenous leukemia (CML) patient exhibits ATP-dependent exclusion of the multidrug resistance (MDR)-type drugs." | 1.33 | The tyrosine kinase inhibitors imatinib and AG957 reverse multidrug resistance in a chronic myelogenous leukemia cell line. ( Dann, EJ; Eytan, GD; Regev, R; Yeheskely-Hayon, D, 2005) |
| "The hallmark of chronic myelogenous leukemia (CML) is the Philadelphia (Ph) chromosome that fuses genetic sequences of the BCR gene on chromosome 22 with c-ABL sequences translocated from chromosome 9." | 1.30 | Effects of the tyrosine kinase inhibitor AG957 and an Anti-Fas receptor antibody on CD34(+) chronic myelogenous leukemia progenitor cells. ( Carlo-Stella, C; Cilloni, D; Colla, S; Garau, D; Gazit, A; Levitzki, A; Regazzi, E; Rizzoli, V; Sammarelli, G; Savoldo, B; Tabilio, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chandra, J | 1 |
| Hackbarth, J | 1 |
| Le, S | 1 |
| Loegering, D | 1 |
| Bone, N | 1 |
| Bruzek, LM | 1 |
| Narayanan, VL | 2 |
| Adjei, AA | 1 |
| Kay, NE | 1 |
| Tefferi, A | 2 |
| Karp, JE | 1 |
| Sausville, EA | 2 |
| Kaufmann, SH | 2 |
| Ackermann, U | 1 |
| Tochon-Danguy, HJ | 1 |
| Nerrie, M | 1 |
| Nice, EC | 1 |
| Sachinidis, JI | 1 |
| Scott, AM | 1 |
| Yeheskely-Hayon, D | 1 |
| Regev, R | 1 |
| Eytan, GD | 1 |
| Dann, EJ | 1 |
| Bhatia, R | 2 |
| Munthe, HA | 2 |
| Verfaillie, CM | 1 |
| Carlo-Stella, C | 1 |
| Regazzi, E | 1 |
| Sammarelli, G | 1 |
| Colla, S | 1 |
| Garau, D | 1 |
| Gazit, A | 1 |
| Savoldo, B | 1 |
| Cilloni, D | 1 |
| Tabilio, A | 1 |
| Levitzki, A | 1 |
| Rizzoli, V | 1 |
| Svingen, PA | 1 |
| Kottke, TJ | 1 |
| Kaur, G | 1 |
| Deutsch, E | 1 |
| Dugray, A | 1 |
| AbdulKarim, B | 1 |
| Marangoni, E | 1 |
| Maggiorella, L | 1 |
| Vaganay, S | 1 |
| M'Kacher, R | 1 |
| Rasy, SD | 1 |
| Eschwege, F | 1 |
| Vainchenker, W | 1 |
| Turhan, AG | 1 |
| Bourhis, J | 1 |
| Forman, SJ | 1 |
8 other studies available for tyrphostin ag957 and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells.
Topics: Acetylcysteine; Adamantane; Antioxidants; Apoptosis; Buthionine Sulfoximine; DNA Damage; DNA, Neopla | 2003 |
Synthesis, 11C labeling and biological properties of derivatives of the tyrphostin AG957.
Topics: Carbon Radioisotopes; Cell Line, Tumor; Cell Proliferation; Humans; Isotope Labeling; Leukemia, Myel | 2005 |
The tyrosine kinase inhibitors imatinib and AG957 reverse multidrug resistance in a chronic myelogenous leukemia cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Biologic | 2005 |
Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors.
Topics: Cell Adhesion; Cell Division; Cells, Cultured; Fibronectins; Fusion Proteins, bcr-abl; Hematopoietic | 1998 |
Effects of the tyrosine kinase inhibitor AG957 and an Anti-Fas receptor antibody on CD34(+) chronic myelogenous leukemia progenitor cells.
Topics: Adult; Antibodies, Monoclonal; Apoptosis; Enzyme Inhibitors; fas Receptor; Female; Flow Cytometry; H | 1999 |
Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro.
Topics: Adamantane; Apoptosis; Caspase 9; Caspases; Cell Division; Enzyme Inhibitors; Fusion Proteins, bcr-a | 2000 |
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
Topics: Acetylcysteine; Animals; Apoptosis; Blast Crisis; Child; Cysteine Endopeptidases; DNA Repair; DNA-Ac | 2001 |
Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors.
Topics: Androstadienes; Case-Control Studies; Cell Adhesion; Cell Cycle Proteins; Cell Movement; Cells, Cult | 2001 |