tyrosine has been researched along with Thyroid Neoplasms in 65 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 18 (27.69) | 18.7374 |
1990's | 7 (10.77) | 18.2507 |
2000's | 28 (43.08) | 29.6817 |
2010's | 6 (9.23) | 24.3611 |
2020's | 6 (9.23) | 2.80 |
Authors | Studies |
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Bianchini, A; Bizzarri, G; Coccaro, C; Deiana, MG; Guglielmi, R; Monti, S; Papini, E; Persichetti, A; Presciuttini, F; Triggiani, V | 1 |
MacPherson, DS; McPhee, SA; Ulijn, RV; Zeglis, BM | 1 |
Chin, L; Han, H; Ma, X; Zhu, Z | 1 |
Guo, F; Hasegawa, A; Hiroshima, K; Katoh, R; Nagasaka, T; Nakazawa, T; Wu, D; Yoshida, K | 1 |
Hellmann, A; Korczynska, J; Mika, A; Taciak, A; Turyn, J; Zwara, A | 1 |
Enomoto, K; Gunduz, M; Hotomi, M; Muragaki, Y; Onoda, N; Sato, F; Tamagawa, S; Uchino, S | 1 |
Dong, S; Dong, W; Liu, J; Shen, Y; Zhang, J; Zhang, L; Zhou, H | 1 |
Madhuri, R; Patra, S; Roy, E; Sharma, PK | 1 |
Cheng, SY; Park, JW; Willingham, MC; Zhao, L | 1 |
Huang, J; Mei, W; Wang, K; Zheng, X | 1 |
Bongarzone, I; Cassinelli, G; Cremona, M; Cuccuru, G; Gorla, L; Lanzi, C; Miccichè, F; Mondellini, P; Pierotti, MA | 1 |
Hirokawa, M; Kodama, R; Miyauchi, A; Nakamura, Y; Sanke, T; Takamura, Y; Yasuoka, H | 1 |
Bai, XH; De Falco, V; Kapus, A; Liu, M; Lodyga, M; Melillo, RM; Santoro, M | 1 |
Bendlova, B; Bilek, R; Dvorakova, K; Dvorakova, S; Skaba, R; Sykorova, V; Vaclavikova, E; Vlcek, P; Zelinka, T | 1 |
Santoro, M; Wells, SA | 1 |
Cho, NL; Du, J; Ito, H; Lin, CI; Moore, FD; Ruan, DT; Whang, EE | 1 |
Almeida, A; Bromberg, JF; Couto, JP; Daly, L; Soares, P; Sobrinho-Simões, M | 1 |
Balsalobre, MD; Carbonell, P; Glower, G; Parrilla, P; Pomares, F; Ríos, A; Rodríguez, GJ; Sola, J; Tébar, J; Torregrosa, NM | 1 |
Dinauer, C; Fenton, C; Francis, GL; Patel, A; Powers, PA; Terrell, R; Tuttle, RM | 1 |
Chung, HK; Hemmings, BA; Hwang, ES; Hwang, IY; Hwang, JH; Kim, DW; Kim, H; Kim, JM; Park, J; Park, KC; Shong, M; Song, JH; Suh, JM | 1 |
JONES, EE; LIU, A; PITTMAN, CS | 1 |
LEMARCHAND BERAUD, T; SCAZZIGA, BR; VANNOTTI, A | 1 |
HALES, IB; MYHILL, J; REEVE, TS; RICHARDS, M; STANLEY, PG | 1 |
Brockman, D; Fagin, JA; Kim, HW; Knauf, JA; Millhorn, DE; Mitsutake, N; Moretti, S; Myatt, L; Puxeddu, E; Seta, KA | 1 |
Basolo, F; Castellone, MD; Celetti, A; Cirafici, AM; Curcio, F; Fusco, A; Giannini, R; Guarino, V; Kruhoffer, M; Medico, E; Melillo, RM; Orntoft, TF; Santoro, M | 1 |
Ain, KB; Dziba, JM | 1 |
Gavrilov, VB; Konev, SV; Lobko, NF | 1 |
Chung, HK; Hwang, ES; Hwang, JH; Jung, HS; Kim, DW; Kim, JM; Park, KC; Park, SH; Park, YJ; Shong, M; Song, JH; Suh, JM; Yun, HJ | 1 |
Greco, A; Miranda, C; Pagliardini, S; Pierotti, MA; Raho, G; Roccato, E | 1 |
Chiariotti, L; Florio, T; Fusco, A; Iuliano, R; Pera, IL; Santoro, M; Schettini, G; Susini, C; Trapasso, F; Viglietto, G | 1 |
Chung, HK; Hwang, JH; Jo, KW; Jo, YS; Jung, HS; Kim, DW; Park, JS; Park, KC; Park, SH; Shong, M; Song, JH | 1 |
Chan, EC; Chang, CA; Chen, KT; Lin, JD; Liou, MJ; Weng, HF | 1 |
Du, L; Kim, LT; Nwariaku, FE; Panta, GR | 1 |
Kitahara, S; Matsubara, O; Murakawa, T; Tanabe, T; Tanimoto, T; Tsuda, H | 1 |
Kakudo, K; Miyauchi, A; Nakamura, M; Nakamura, Y; Takamura, Y; Yasuoka, H; Zuo, H | 1 |
Acunzo, M; Carlomagno, F; Carlomagno, SM; Catania, A; Chiariello, M; Iavarone, C; Melillo, RM; Santoro, M | 1 |
Becherini, L; Cantini, G; Ercolino, T; Gaglianò, MS; Lombardi, A; Luconi, M; Mannelli, M; Piscitelli, E; Serio, M | 1 |
Hosain, H; Spencer, RP | 1 |
Arighi, E; Bongarzone, I; Borrello, MG; Carcano, C; Della Porta, G; Ferraresi, G; Mondellini, P; Monzini, N; Pierotti, MA | 1 |
Beinfeld, MC | 1 |
Ceccherini, I; Elisei, R; Mancusi, F; Martino, E; Molinaro, E; Pacini, F; Pinchera, A; Romei, C; Romeo, G | 1 |
Asai, N; Ito, S; Iwashita, T; Murakami, H; Takahashi, M | 1 |
Bergström, JD; Diaz de Ståhl, T; Heldin, NE; Hermansson, A | 1 |
Arena, N; de Luca, A; Medico, E; Sena, LM | 1 |
Dinauer, CA; Fenton, C; Gary, FL; Nikiforov, YE; Patel, A; Ramirez, R; Tuttle, RM | 1 |
Barone, MV; Chiappetta, G; Fenzi, G; Fusco, A; Melillo, RM; Mineo, A; Salvatore, D; Salvatore, G; Santoro, M; Vecchio, G | 1 |
Fenzi, G; Fusco, A; Melillo, RM; Monaco, C; Salvatore, D; Santoro, M; Vecchio, G; Visconti, R | 1 |
Alberti, L; Arighi, E; Borrello, MG; Ghizzoni, S; Gishizky, ML; Mercalli, E; Pierotti, MA; Radice, MT; Sangregorio, R | 1 |
Frasca, F; Vella, V; Vigneri, P; Vigneri, R; Wang, JY | 1 |
Blanes, A; de Miguel, M; Diaz-Cano, SJ; Tashjian, R; Wolfe, HJ | 1 |
Shimaoka, K; Volpert, EM | 1 |
Prezyma, AP; Volpert, EM | 1 |
Bongarzone, I; Borrello, MG; Della Porta, G; Fusco, A; Gambetta, RA; Grieco, M; Lanzi, C; Migliazza, A; Santoro, M; Zunino, F | 1 |
Magner, JA; Miura, Y; Perkel, VS | 1 |
Felts, JH; King, JS | 1 |
Atkins, FL; Beaven, MA; Keiser, HR | 1 |
Lemarchand-Béraud, T; Valenta, L | 1 |
Ewen, SW; Pearse, AG; Polak, JM | 1 |
Berger, J; Bouhnik, J; Etling, N | 1 |
Lissitzky, S; Rolland, M; Roques, M; Torresani, J; Valenta, L | 1 |
Ling, RC; Wu, C | 1 |
Etling, N; Lumbroso, P; Vallée, G | 1 |
Werner, SC | 1 |
Kusakabe, T; Miyake, T | 1 |
Jones, JE; Shultz, JS | 1 |
1 review(s) available for tyrosine and Thyroid Neoplasms
Article | Year |
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Targeting the RET pathway in thyroid cancer.
Topics: Alleles; Clinical Trials as Topic; Dimerization; Humans; Medical Oncology; Models, Biological; Mutation; Phenotype; Phosphorylation; Point Mutation; Protein Binding; Proto-Oncogene Proteins c-ret; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2009 |
64 other study(ies) available for tyrosine and Thyroid Neoplasms
Article | Year |
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Combined Treatment with Laser Ablation and Tyrosine-Kinase Inhibitor as A Novel Multimodality Approach to Locally Advanced Thyroid Cancer: A Case Report.
Topics: Aged; Female; Humans; Iodine Radioisotopes; Laser Therapy; Protein Kinase Inhibitors; Thyroid Neoplasms; Tyrosine | 2022 |
The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences.
Topics: Halogenation; Humans; Iodine Radioisotopes; Kinetics; Matrix Metalloproteinase 9; Peptides; Thyroid Neoplasms; Tyrosine | 2022 |
A Novel Germline Deletion of p.C630 in RET Causes MTC and Promotes Cell Proliferation and Sensitivity to Pralsetinib.
Topics: Carcinoma, Neuroendocrine; Cell Proliferation; Germ Cells; Germ-Line Mutation; Humans; Ligands; Male; Middle Aged; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyridines; Pyrimidines; Thyroid Neoplasms; Tyrosine | 2022 |
Expression of T-cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domains (TIGIT) in anaplastic thyroid carcinoma.
Topics: Adenocarcinoma, Follicular; Carcinoma, Neuroendocrine; Humans; Immunoglobulins; Receptors, Immunologic; T-Lymphocytes; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Tyrosine | 2022 |
Alterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto's thyroiditis.
Topics: Alanine; Amino Acids; Antibodies; Arginine; Glutamic Acid; Glycine; Hashimoto Disease; Humans; Lysine; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tyrosine | 2023 |
A novel therapeutic approach for anaplastic thyroid cancer through inhibition of LAT1.
Topics: Animals; Antineoplastic Agents; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Mice; Molecular Targeted Therapy; Signal Transduction; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Tyrosine; Xenograft Model Antitumor Assays | 2019 |
Identification of Potential Biomarkers for Thyroid Cancer Using Bioinformatics Strategy: A Study Based on GEO Datasets.
Topics: Androstenes; Biomarkers, Tumor; Clofazimine; Computational Biology; Databases, Genetic; Exosomes; Extracellular Matrix Proteins; Eye Proteins; Fibronectins; Gene Expression Regulation, Neoplastic; Gene Ontology; Gene Regulatory Networks; Genetic Markers; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heparin; Hexamethonium; Humans; Lactams; Nerve Tissue Proteins; Prognosis; Protein Interaction Maps; Receptors, Vasopressin; Signal Transduction; Thyroid Hormones; Thyroid Neoplasms; Transcriptome; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Tyrosine | 2020 |
Imprinted ZnO nanostructure-based electrochemical sensing of calcitonin: a clinical marker for medullary thyroid carcinoma.
Topics: Amino Acid Sequence; Biomarkers, Tumor; Calcitonin; Carcinoma, Neuroendocrine; Chemistry Techniques, Analytical; Electric Impedance; Electrochemistry; Humans; Molecular Imprinting; Molecular Sequence Data; Molecular Weight; Nanostructures; Polymerization; Polymers; Thyroid Neoplasms; Time Factors; Tyrosine; Zinc Oxide | 2015 |
Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Female; Genes, Tumor Suppressor; Humans; Mice; Mice, Nude; Phosphorylation; Point Mutation; Rats; Thyroid Gland; Thyroid Hormone Receptors beta; Thyroid Neoplasms; Tyrosine | 2017 |
Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Activation; Fibroblasts; Humans; Mutant Proteins; Mutation; Phosphorylation; Protein Isoforms; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Receptor, IGF Type 1; Signal Transduction; src-Family Kinases; Thyroid Neoplasms; Tumor Stem Cell Assay; Tyrosine | 2016 |
Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements.
Topics: Animals; Antineoplastic Agents; Carcinoma, Medullary; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Germ-Line Mutation; Humans; Mice; Mice, Nude; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Oncogene Proteins; Phosphorylation; Proteomics; Proto-Oncogene Proteins c-ret; Quinazolines; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2009 |
CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis.
Topics: Carcinoma, Papillary; Cell Line, Tumor; Chemokine CXCL12; Enzyme Inhibitors; Humans; Immunohistochemistry; Lymphatic Metastasis; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroso Compounds; Receptors, CXCR4; RNA, Messenger; Thyroid Neoplasms; Tyrosine | 2008 |
XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blotting, Northern; Bromodeoxyuridine; Carcinoma, Papillary; Cell Proliferation; Flow Cytometry; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine | 2009 |
RET mutation Tyr791Phe: the genetic cause of different diseases derived from neural crest.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Carcinoma, Medullary; Child; Disease; Family; Female; Genetic Association Studies; Germ-Line Mutation; Hirschsprung Disease; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Neural Crest; Phenylalanine; Polymorphism, Single Nucleotide; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms; Tyrosine; Young Adult | 2009 |
Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers.
Topics: Adenocarcinoma, Papillary; Cell Proliferation; Dasatinib; High-Throughput Screening Assays; Humans; Metabolome; Molecular Targeted Therapy; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2012 |
AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Female; Humans; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyrimidines; Signal Transduction; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Tyrosine; Xenograft Model Antitumor Assays | 2012 |
Prophylactic thyroidectomy in MEN 2A syndrome: experience in a single center.
Topics: Adolescent; Adult; Calcitonin; Child; Child, Preschool; Cysteine; Drosophila Proteins; Female; Humans; Infant; Male; Multiple Endocrine Neoplasia Type 2a; Mutation; Neoplasm Recurrence, Local; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Function Tests; Thyroid Neoplasms; Thyroidectomy; Tyrosine | 2002 |
Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents.
Topics: Adenocarcinoma, Follicular; Adolescent; Adult; Carcinoma, Papillary; Child; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Thyroid Neoplasms; Tyrosine | 2002 |
RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Animals; Carcinoma, Papillary; CHO Cells; Cricetinae; Enzyme Inhibitors; Fibroblasts; Humans; Mice; Molecular Sequence Data; Nuclear Receptor Coactivators; Oncogene Proteins; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Thyroid Neoplasms; Transcription Factors; Transcriptional Activation; Tumor Suppressor Protein p53; Tyrosine | 2003 |
HORMONE SYNTHESIS BY A TRANSPLANTABLE THYROID TUMOR IN MICE.
Topics: Adenoma; Chromatography; Diiodotyrosine; Iodine Isotopes; Metabolism; Mice; Neoplasms, Experimental; Propylthiouracil; Research; Thyroid Neoplasms; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine; Tyrosine | 1963 |
[PLASMATIC IODINATED PRODUCTS IN THYROID DISEASES].
Topics: Autoradiography; Blood Chemical Analysis; Chromatography; Diiodotyrosine; Goiter; Humans; Hyperthyroidism; Hypothyroidism; Metabolic Diseases; Thyroid Function Tests; Thyroid Neoplasms; Thyroiditis; Thyroxine; Triiodothyronine; Tyrosine | 1964 |
FUNCTIONING FOLLICULAR METASTATIC CARCINOMA OF THE THYROID.
Topics: Carcinoma; Humans; Iodine Isotopes; Neoplasm Metastasis; Neoplasms; Pathology; Pharmacology; Thoracic Neoplasms; Thyroid Function Tests; Thyroid Neoplasms; Thyroidectomy; Thyroxine; Tyrosine | 1964 |
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway.
Topics: Animals; Blotting, Northern; Carcinoma, Papillary; Cell Line; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Cyclooxygenase 2; Dinoprostone; Disease Progression; Dose-Response Relationship, Drug; Eicosanoids; Gene Library; Humans; Hydroxyeicosatetraenoic Acids; Intramolecular Oxidoreductases; Isoenzymes; Membrane Proteins; Mutation; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Thyroid Neoplasms; Time Factors; Transcription, Genetic; Transcriptional Activation; Tyrosine; Up-Regulation | 2003 |
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Topics: Carcinoma, Papillary; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Collagen; Collagen Type I; DNA; Drug Combinations; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Laminin; Neoplasm Invasiveness; Osteopontin; Phenotype; Phosphorylation; Protein Structure, Tertiary; Proteoglycans; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sialoglycoproteins; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2004 |
Imatinib mesylate (gleevec; STI571) monotherapy is ineffective in suppressing human anaplastic thyroid carcinoma cell growth in vitro.
Topics: Antineoplastic Agents; Benzamides; Carcinoma; Cell Cycle; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression; Genes, abl; Humans; Imatinib Mesylate; Oncogene Proteins; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-kit; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Thyroid Neoplasms; Tyrosine | 2004 |
[Determination of tyrosine- and tryptophan-containing peptides in plasma by absorption in UV spectral region].
Topics: Humans; Hydrogen-Ion Concentration; Oligopeptides; Postoperative Period; Spectrophotometry, Ultraviolet; Thyroid Neoplasms; Thyroxine; Tryptophan; Tyrosine | 2004 |
Regulation of signal transducer and activator of transcription 1 (STAT1) and STAT1-dependent genes by RET/PTC (rearranged in transformation/papillary thyroid carcinoma) oncogenic tyrosine kinases.
Topics: Carcinoma, Papillary; DNA-Binding Proteins; Genes, MHC Class II; HLA-DR Antigens; Humans; Interferon Regulatory Factor-1; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Nuclear Proteins; Oncogene Proteins; Oncogene Proteins, Fusion; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Inhibitors of Activated STAT; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; STAT1 Transcription Factor; Thyroid Neoplasms; Trans-Activators; Transcriptional Activation; Tyrosine | 2004 |
Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein.
Topics: Animals; Catalysis; Down-Regulation; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Mice; Mutagenesis; NIH 3T3 Cells; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Receptor, trkA; Thyroid Neoplasms; Tyrosine | 2005 |
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.
Topics: Animals; Blotting, Western; Cell Adhesion; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Humans; Immunoblotting; Immunoprecipitation; Mutation; Neoplasms; Paxillin; Peptides; Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 3; src-Family Kinases; Thyroid Gland; Thyroid Neoplasms; Transfection; Tyrosine | 2005 |
Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases.
Topics: Animals; Carcinoma, Papillary; Cells, Cultured; Cytoplasm; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Thyroid Gland; Thyroid Neoplasms; Tyrosine | 2005 |
An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.
Topics: Adenocarcinoma, Follicular; Adenocarcinoma, Papillary; Autocrine Communication; Blotting, Western; Cell Proliferation; DNA, Complementary; Enzyme Activation; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Phosphorylation; Platelet-Derived Growth Factor; Receptor, Platelet-Derived Growth Factor alpha; RNA, Messenger; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2006 |
Direct phosphorylation of proliferative and survival pathway proteins by RET.
Topics: Carcinoma, Medullary; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2005 |
Expression of KIT, EGFR, HER-2 and tyrosine phosphorylation in undifferentiated thyroid carcinoma: implication for a new therapeutic approach.
Topics: Antigens, Neoplasm; Carcinoma, Papillary; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; DNA-Binding Proteins; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Receptor, ErbB-2; RNA, Messenger; Thyroid Neoplasms; Tyrosine | 2005 |
Nitric oxide in papillary thyroid carcinoma: induction of vascular endothelial growth factor D and correlation with lymph node metastasis.
Topics: Adolescent; Adult; Aged; Carcinoma, Papillary; Cell Line, Tumor; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; RNA, Messenger; Thyroid Neoplasms; Tyrosine; Vascular Endothelial Growth Factor D | 2006 |
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Genetic Vectors; Humans; MAP Kinase Signaling System; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-ret; Signal Transduction; src-Family Kinases; Thyroid Neoplasms; Transfection; Tyrosine | 2006 |
The Y606C RET mutation causes a receptor gain of function.
Topics: Amino Acid Substitution; Animals; Base Sequence; Carcinoma, Medullary; Cysteine; Female; Germ-Line Mutation; Humans; Mice; Middle Aged; Multiple Endocrine Neoplasia Type 2a; NIH 3T3 Cells; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms; Tyrosine | 2008 |
Thionamides and analogues: a reapraisal of antithyroid and thyroid carcinogenic effects.
Topics: Antithyroid Agents; Carcinogens; Chemical Phenomena; Chemistry; Pyridines; Structure-Activity Relationship; Thiobarbiturates; Thiones; Thiourea; Thyroid Hormones; Thyroid Neoplasms; Tyrosine | 1980 |
Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Transformation, Neoplastic; Cloning, Molecular; DNA; Drosophila Proteins; Gene Expression Regulation; Gene Rearrangement; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Thyroid Neoplasms; Tyrosine | 1993 |
Inhibition of pro-cholecystokinin (CCK) sulfation by treatment with sodium chlorate alters its processing and decreases cellular content and secretion of CCK 8.
Topics: Animals; Carcinoma; Chlorates; Cholecystokinin; Culture Media; Protein Precursors; Rats; Receptors, Cholecystokinin; Sincalide; Sulfates; Sulfur Radioisotopes; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine | 1994 |
Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence.
Topics: Adult; Aged; Amino Acid Sequence; Base Sequence; Calcitonin; Carcinoma, Medullary; Cysteine; DNA; DNA Primers; DNA, Neoplasm; Drosophila Proteins; Exons; Female; Humans; Male; Middle Aged; Molecular Sequence Data; Neoplasm Staging; Point Mutation; Polymerase Chain Reaction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Recurrence; Restriction Mapping; Thyroid Neoplasms; Tyrosine | 1996 |
Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.
Topics: Carcinoma, Medullary; Drosophila Proteins; Hirschsprung Disease; Humans; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms; Tyrosine | 1998 |
Non-autocrine, constitutive activation of Met in human anaplastic thyroid carcinoma cells in culture.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Blotting, Northern; Carcinoma; Enzyme Activation; Humans; Liver Neoplasms; Phosphorylation; Precipitin Tests; Proteins; Proto-Oncogene Proteins c-met; Reverse Transcriptase Polymerase Chain Reaction; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Thyroid Gland; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine | 1999 |
Met overexpression confers HGF-dependent invasive phenotype to human thyroid carcinoma cells in vitro.
Topics: Carcinoma; Cell Division; Cell Movement; Drug Resistance, Neoplasm; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Phenotype; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine; Wound Healing | 1999 |
Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults.
Topics: Adolescent; Adult; Carcinoma, Papillary; Child; Endothelial Growth Factors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphokines; Male; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Registries; Thyroid Neoplasms; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors | 2000 |
Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.
Topics: Amino Acid Sequence; Animals; Antibodies, Blocking; COS Cells; DNA; Drosophila Proteins; Fibroblasts; Humans; Immunohistochemistry; Microinjections; Molecular Sequence Data; Oncogene Proteins; Oncogenes; Phosphorylation; Point Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms; Transfection; Tumor Cells, Cultured; Tyrosine | 2000 |
Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; COS Cells; Drosophila Proteins; Enzyme Activation; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; ras Proteins; Rats; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Thyroid Neoplasms; Tyrosine | 2001 |
Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Amino Acid Substitution; Animals; Carcinoma, Papillary; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; COS Cells; Drosophila Proteins; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oncogenes; Protein Isoforms; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Thyroid Neoplasms; Transfection; Tyrosine | 2001 |
Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor.
Topics: Antineoplastic Agents; Benzamides; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Hepatocyte Growth Factor; Humans; Imatinib Mesylate; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morphogenesis; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyrimidines; Thyroid Gland; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine | 2001 |
Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia.
Topics: Amino Acid Substitution; Antigens, Nuclear; Autoantigens; Calcitonin; Carcinoma, Medullary; Cysteine; DNA Primers; Drosophila Proteins; Female; Focal Epithelial Hyperplasia; Genes, Retinoblastoma; Germ-Line Mutation; Humans; Ki-67 Antigen; Loss of Heterozygosity; Multiple Endocrine Neoplasia Type 2a; Nerve Tissue Proteins; Neurofibromin 1; Nuclear Proteins; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Diseases; Thyroid Neoplasms; Thyroidectomy; Tyrosine | 2001 |
Iodoamino acids in abnormal and grossly normal thyroids: Comparison between 125I and 127I distribution.
Topics: Adenoma; Adult; Aged; Amino Acids; Carcinoma, Papillary; Cysts; Female; Goiter, Nodular; Humans; Iodine Isotopes; Iodine Radioisotopes; Isotope Labeling; Male; Middle Aged; Thyroid Diseases; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Triiodothyronine; Tyrosine | 1977 |
Transplantable thyroid tumour in rats: iodoamino acid distribution in successive tumour generations.
Topics: Amino Acids; Animals; Diiodotyrosine; Female; Iodine Radioisotopes; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Time Factors; Triiodothyronine; Tyrosine | 1977 |
Identification of the product of two oncogenic rearranged forms of the RET proto-oncogene in papillary thyroid carcinomas.
Topics: 3T3 Cells; Animals; Blotting, Western; Carcinoma, Papillary; Drosophila Proteins; Gene Rearrangement; Humans; Mice; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tyrosine | 1992 |
Rates of processing of the high mannose oligosaccharide units at the three glycosylation sites of mouse thyrotropin and the two sites of free alpha-subunits.
Topics: Amino Acid Sequence; Animals; Carbon Radioisotopes; Glycoprotein Hormones, alpha Subunit; Glycosylation; Kinetics; Macromolecular Substances; Mannose; Mice; Oligosaccharides; Pituitary Hormones, Anterior; Protein Processing, Post-Translational; Thyroid Neoplasms; Thyrotropin; Tritium; Tyrosine | 1988 |
Enhanced excretion of free amino acids by hyperthyroid patients.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Amino Acids; Aminoisobutyric Acids; Calcium; Cholesterol; Exophthalmos; Fasting; Female; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Middle Aged; Phosphorus; Renal Aminoacidurias; Thyroid Function Tests; Thyroid Neoplasms; Tyrosine | 1971 |
Dopa decarboxylase in medullary carcinoma of the thyroid.
Topics: Adrenal Gland Neoplasms; Amine Oxidase (Copper-Containing); Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Carcinoma; Cresols; Dihydroxyphenylalanine; Dopa Decarboxylase; Histamine; Histidine; Humans; Hydrazines; Hydroxylamines; Methyldopa; Methylhistidines; Norepinephrine; Pheochromocytoma; Serotonin; Thyroid Gland; Thyroid Neoplasms; Tryptophan; Tyrosine; Tyrosine 3-Monooxygenase | 1973 |
Thyroglobulin and thyroid acid protease activity in thyroid disease.
Topics: Adenoma; Fluorometry; Graves Disease; Humans; Hydrogen-Ion Concentration; Iodine; Peptide Hydrolases; Proteins; Spectrophotometry; Thyroglobulin; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland; Thyroid Neoplasms; Thyroiditis, Autoimmune; Thyroxine; Tyrosine | 1970 |
The genesis of apudamyloid in endocrine polypeptide tumours: histochemical distinction from immunamyloid.
Topics: Adenocarcinoma, Scirrhous; Adenoma, Islet Cell; Adrenal Gland Neoplasms; Amyloidosis; Arthritis, Rheumatoid; Carcinoma; Endocrine System Diseases; Histocytochemistry; Humans; Microscopy, Electron; Neoplasm Proteins; Neoplasms; Pancreatic Neoplasms; Pheochromocytoma; Thyroid Neoplasms; Tryptophan Oxygenase; Tyrosine | 1972 |
[Action "in vitro" of 2 histological fixatives on the iodine content of human thyroid tissue].
Topics: Adenoma; Autoradiography; Chromatography; Goiter; Histological Techniques; Humans; In Vitro Techniques; Iodine Radioisotopes; Methods; Monoiodotyrosine; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms; Tyrosine | 1968 |
Human thyroglobulin. Physicochemical properties in relation to iodine content.
Topics: Adenoma; Animals; Carcinoma; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography, Ion Exchange; Electrophoresis, Disc; Goiter; Humans; Hydrogen-Ion Concentration; Immunodiffusion; Iodine; Iodine Isotopes; Sheep; Thyroglobulin; Thyroid Neoplasms; Tyrosine; Ultracentrifugation | 1968 |
Determination of iodoamino acids and inorganic iodide by thin-layer chromatography.
Topics: Alcohols; Animals; Butanones; Chromatography, Thin Layer; Diiodotyrosine; Iodides; Iodine; Iodine Isotopes; Methods; Monoiodotyrosine; Quaternary Ammonium Compounds; Rats; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Triiodothyronine; Tyrosine | 1970 |
[Study of compounds labelled with I-131 present in fluids extracted by puncture from certain hot thyroid nodules].
Topics: Blood Proteins; Humans; In Vitro Techniques; Iodine Radioisotopes; Neoplasm Proteins; Thyroid Neoplasms; Tyrosine | 1965 |
Radioiodine tests of thyroid function and thyroid-scanning--a critical review.
Topics: Autoradiography; Diiodotyrosine; Humans; Iodine Radioisotopes; Thyroid Function Tests; Thyroid Neoplasms; Thyrotropin; Triiodothyronine; Tyrosine | 1965 |
Iodotyrosine deiodinase isozymes in the normal and in thyroid diseases.
Topics: Electrophoresis; Humans; Hyperthyroidism; In Vitro Techniques; Iodine Isotopes; Isoenzymes; Kidney; Liver; Microsomes; Mitochondria; Thyroid Gland; Thyroid Neoplasms; Tyrosine | 1966 |
Identification of thyroidal iodoamino acids by gel filtration and automated 127-I determination.
Topics: Autoanalysis; Chromatography, Gel; Diiodotyrosine; Goiter; Humans; In Vitro Techniques; Iodides; Iodine Radioisotopes; Thyroid Gland; Thyroid Neoplasms; Thyroiditis, Autoimmune; Thyroxine; Triiodothyronine; Tyrosine | 1966 |