tyrosine has been researched along with Proteinuria in 36 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 10 (27.78) | 18.7374 |
1990's | 2 (5.56) | 18.2507 |
2000's | 15 (41.67) | 29.6817 |
2010's | 8 (22.22) | 24.3611 |
2020's | 1 (2.78) | 2.80 |
Authors | Studies |
---|---|
Abramson, MH; Adegbite, BO; Azeloglu, EU; Berman, EM; Campbell, KN; Chan, L; Chauhan, K; Coca, SG; El Ghaity-Beckley, S; Gutgarts, V; Jaimes, EA; Kremyanskaya, M; Marcellino, B; Mascarenhas, JO; Meliambro, KA; Musteata, FM; Muwonge, AN; Salvatore, SP | 1 |
Aoudjit, L; Eremina, V; Hardy, WR; Jones, N; Martin, CE; Petersen, KA; Quaggin, SE; Takano, T; Tilak, M | 1 |
Csont, T; Erdélyi, K; Godó, M; Hamar, P; Kaucsár, T; Kiss, N; Kökény, G; Krenács, T; Lajtár, E; Pacher, P; Révész, C; Sárközy, M; Szalay, CI; Szénási, G | 1 |
Aizawa, K; Endo, K; Hirata, M; Kawasaki, R; Serizawa, K; Tashiro, Y; Yogo, K | 1 |
Avila-Casado, C; Franco, M; Johnson, RJ; Martínez-Martínez, CM; Medina-Campos, ON; Pedraza-Chaverrí, J; Rodríguez-Iturbe, B; Sánchez-González, DJ; Sánchez-Lozada, LG; Soto, V; Tapia, E | 1 |
Higo, S; Jiang, QY; Kasuga, M; Kitazawa, R; Kitazawa, S; Miyata, S | 1 |
Ferrario, CM; Habibi, J; Johnson, M; Rehmer, J; Rehmer, N; Sowers, JR; Tilmon, R; Whaley-Connell, A; Wiedmeyer, C | 1 |
Asamiya, Y; Horita, S; Nitta, K; Ohashi, T; Ohno, M; Tsuruta, Y; Uchida, K | 1 |
Defesche, JC; Hollak, CE; Holleboom, AG; Hovingh, GK; Kastelein, JJ; Kuivenhoven, JA; Levels, JH; Peter, J; Schimmel, AW; Stroes, ES; Valentijn, RM; van Olden, CC; Vos, P | 1 |
Harita, Y; Hattori, M; Hattori, S; Horita, S; Igarashi, T; Kajiho, Y; Kanda, S; Kurihara, H; Matsunaga, A; Miura, K; Sekine, T; Sugawara, N; Tsurumi, H | 1 |
Bencsik, P; Csonka, C; Csont, T; Ferdinandy, P; Kocsis, GF; Pálóczi, J; Pipicz, M; Sárközy, M; Varga, ZV | 1 |
Aypar, U; Orhan, H; Sahin, A; Sahin, G; Vermeulen, NP | 1 |
Hunt, MJ; Sood, HS; Tyagi, SC | 1 |
GENTZ, J; JAGENBURG, R; ZETTERSTROEM, R | 1 |
Barrera, D; Correa-Rotter, R; Cruz, C; Hernández-Pando, R; Juárez-Nicolás, C; Medina-Campos, ON; Murguía, F; Pedraza-Chaverrí, J; Torres, N; Tovar, AR | 1 |
Cho, EJ; Rhyu, DY; Yokozawa, T | 1 |
Lominadze, D; Moshal, KS; Ovechkin, AV; Tyagi, N; Tyagi, SC | 1 |
Fujimoto, S; Haruna, Y; Kashihara, N; Komai, N; Namikoshi, T; Ohzeki, M; Sasaki, T; Tomita, N; Yoshida, A | 1 |
Aguilar, D; Chirino, YI; Correa-Rotter, R; Cruz, C; Hernández-Pando, R; Maldonado, PD; Martínez-Martínez, CM; Medina-Campos, ON; Pedraza-Chaverri, J; Sánchez-González, DJ; Tapia, E | 1 |
Ferrebuz, A; Quiroz, Y; Rodriguez-Iturbe, B; Romero, F; Vaziri, ND | 1 |
Castillo-Henkel, C; Escalante, B; Jarillo Luna, RA; Medina-Santillan, R; Mendoza, MG; Rios, A; Robles, HV; Romo, E | 1 |
Bert, JK; Moore, KE; Wright, PF | 1 |
Fällström, SP; Lindblad, B; Steen, G | 1 |
Cohen, DS; Dotson, RA; Graybill, SR; Mathis, JE; Wosu, NJ | 1 |
Beck, M; Bökenkamp, A; Lentze, MJ; Liappis, N | 1 |
Albrecht, EW; Bakker, WW; de Jager-Krikken, A; Heeringa, P; Klok, PA; Moshage, H; van der Horst, ML; van Goor, H | 1 |
Fujita, T; Goto, A; Onozato, ML; Tojo, A; Wilcox, CS | 1 |
Iwao, H; Kawano, H; Kim, S; Zhan, Y | 1 |
Askenasi, R; Gregoire, F | 1 |
Hjalmarson, O; Holme, E; Lindstedt, S; Lock, EA; Strandvik, B | 1 |
Perheentupa, J | 1 |
Century, B; Natelson, S; Vorkink, WP | 1 |
Simon, C | 1 |
Giorgio, AJ; Linarelli, LG; Macdonald, RR; Rubin, HM | 1 |
Berggård, I; Evrin, PE; Peterson, PA | 1 |
Hamilton, PB; Lou, MF | 1 |
1 trial(s) available for tyrosine and Proteinuria
Article | Year |
---|---|
Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.
Topics: Acetone; Aldehydes; Anesthetics, Inhalation; Biomarkers; Female; Glycosuria; Halothane; Humans; Isoflurane; Kidney; Kidney Diseases; Lipids; Male; Methyl Ethers; Oxidation-Reduction; Proteinuria; Sevoflurane; Tyrosine | 2013 |
35 other study(ies) available for tyrosine and Proteinuria
Article | Year |
---|---|
Patient-Specific Pharmacokinetics and Dasatinib Nephrotoxicity.
Topics: Albuminuria; Dasatinib; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Proteinuria; Tyrosine | 2023 |
ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies.
Topics: Animals; Biotinylation; Cell Membrane; Cytosol; Endocytosis; HEK293 Cells; Humans; Kidney Diseases; Male; Membrane Proteins; Nephrosis; Phosphorylation; Podocytes; Proteinuria; Rats; Rats, Sprague-Dawley; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Up-Regulation | 2018 |
Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain.
Topics: Aldehydes; Animals; Body Weight; Chemokine CCL2; Connective Tissue Growth Factor; Disease Progression; Disease Resistance; Dose-Response Relationship, Drug; Doxorubicin; Fibrosis; Kidney; Male; Membrane Proteins; Oxidative Stress; Proteinuria; Rats; Reactive Nitrogen Species; Species Specificity; Transforming Growth Factor beta1; Tyrosine | 2015 |
Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats.
Topics: Animals; Blood Pressure; Body Weight; Creatinine; Disease Models, Animal; Endothelium, Vascular; Erythropoietin; Femoral Artery; Heart Rate; Hemoglobins; Kidney Function Tests; Male; NADPH Oxidase 4; NADPH Oxidases; Nephrectomy; Nitric Oxide Synthase Type III; Nitroglycerin; Polyethylene Glycols; Proteinuria; Rats; Renal Insufficiency, Chronic; Tyrosine; Ultrasonography; Vasodilation | 2015 |
Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria.
Topics: Aldehydes; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Pressure; Glomerular Filtration Rate; Glutathione Reductase; Hypertension, Renal; Kidney; Kidney Glomerulus; Male; Nitric Oxide Synthase Type II; Organ Size; Oxidative Stress; Peroxidases; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Renal Plasma Flow; Superoxide Dismutase; Thiocarbamates; Transcription Factor RelA; Tyrosine | 2008 |
Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Blood Glucose; Body Weight; Deoxyguanosine; Diabetic Nephropathies; Disease Progression; Glycated Hemoglobin; Immunohistochemistry; Male; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Taurine; Tyrosine | 2008 |
Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Disease Models, Animal; Ethanolamines; Hypertension, Renal; NADPH Oxidases; Nebivolol; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Podocytes; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Reactive Oxygen Species; Renin; Renin-Angiotensin System; Tyrosine | 2009 |
Phosphorylation status of nephrin in human membranous nephropathy.
Topics: Aged; Fluorescent Antibody Technique; Glomerulonephritis, Membranous; Humans; Kidney Glomerulus; Membrane Proteins; Microscopy, Immunoelectron; Middle Aged; Phosphorylation; Proteinuria; Tyrosine | 2010 |
Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase.
Topics: Adolescent; Anemia, Hemolytic; Angiotensin-Converting Enzyme Inhibitors; Animals; Child; Child, Preschool; Chlorocebus aethiops; Cholesterol, HDL; Corneal Opacity; COS Cells; Cysteine; Disulfides; Diuretics; Female; Genetic Predisposition to Disease; Homozygote; Humans; Lecithin Cholesterol Acyltransferase Deficiency; Male; Mutation; Phosphatidylcholine-Sterol O-Acyltransferase; Proteinuria; Transfection; Treatment Outcome; Tyrosine | 2011 |
SIRPα interacts with nephrin at the podocyte slit diaphragm.
Topics: Animals; Antigens, Differentiation; Disease Models, Animal; Humans; Kidney Glomerulus; Membrane Proteins; Mutation; Nephrotic Syndrome; Phosphorylation; Podocytes; Protein Binding; Proteinuria; Rats; Receptors, Immunologic; Tyrosine | 2012 |
Preconditioning protects the heart in a prolonged uremic condition.
Topics: Angiotensin II; Animals; Biomarkers; Creatinine; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Urea; Uremia; Uric Acid; Ventricular Function, Left | 2012 |
Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia.
Topics: Animals; Aorta; Blood Pressure; Clofibric Acid; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Fibric Acids; Genotype; Homocysteine; Hyperhomocysteinemia; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Peroxisome Proliferators; Phenotype; Proteinuria; Tyrosine | 2003 |
TYROSINEMIA.
Topics: Acid-Base Equilibrium; Amino Acid Metabolism, Inborn Errors; Biochemical Phenomena; Biochemistry; Blood; Child; Chronic Kidney Disease-Mineral and Bone Disorder; Drug Therapy; Fanconi Syndrome; Genetics, Medical; Humans; Infant; Infant, Newborn; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Liver Cirrhosis; Liver Function Tests; Pathology; Pigmentation Disorders; Prognosis; Proteinuria; Radiography; Rickets; Thrombocytopenia; Tyrosine; Tyrosinemias; Vitamin D; Water-Electrolyte Balance | 1965 |
Soy protein diet ameliorates renal nitrotyrosine formation and chronic nephropathy induced by puromycin aminonucleoside.
Topics: Animals; Antimetabolites; Antioxidants; Blood Urea Nitrogen; Body Weight; Catalase; Cholesterol; Creatinine; Diet; Eating; Glutathione Peroxidase; Glycine max; Immunohistochemistry; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Lipids; Male; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Wistar; Soybean Proteins; Superoxide Dismutase; Tyrosine | 2004 |
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Isoindoles; Japan; Kidney; Lipopolysaccharides; Lysine; Male; Nitric Oxide; Organoselenium Compounds; Peroxidase; Phytotherapy; Plant Extracts; Plant Roots; Proteinuria; Rats; Rats, Wistar; Reperfusion Injury; Rheum; Superoxide Dismutase; Tyrosine; Uric Acid; Zinc | 2004 |
Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model.
Topics: Acetylcholine; Animals; Blotting, Western; Collagen; Endothelin-1; Endothelium, Vascular; Fibrosis; Homocysteine; Hypertension, Renovascular; Hypoglycemic Agents; Kidney; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Nitroprusside; PPAR gamma; Proteinuria; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Tyrosine; Vasodilator Agents; Ventricular Remodeling | 2005 |
Isohumulones derived from hops ameliorate renal injury via an anti-oxidative effect in Dahl salt-sensitive rats.
Topics: Animals; Antioxidants; Blood Pressure; Blotting, Western; Cyclopentanes; Humulus; Hypertension; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Proteinuria; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Sodium Chloride; Tyrosine | 2007 |
Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Blood Urea Nitrogen; Creatinine; Cysteine; Cytoprotection; Garlic; Hypertension; Kidney; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Nephrectomy; Nitric Oxide Synthase Type II; Plant Extracts; Poly Adenosine Diphosphate Ribose; Proteinuria; Rats; Rats, Wistar; Superoxide Dismutase; Systole; Tyrosine | 2007 |
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
Topics: Actins; Animals; Blood Pressure; Cell Movement; Collagen Type IV; Creatinine; Disease Models, Animal; Hypertension; Hypertrophy; Inflammation; Kidney; Kidney Failure, Chronic; Leukocytes; Male; Malondialdehyde; Melatonin; Nephrectomy; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Transforming Growth Factor beta; Tyrosine | 2008 |
Kidney damage after renal ablation is worsened in endothelial nitric oxide synthase -/- mice and improved by combined administration of L-arginine and antioxidants.
Topics: Animals; Antioxidants; Arginine; Blood Pressure; Disease Models, Animal; Drug Combinations; Kidney; Kidney Failure, Chronic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteinuria; Superoxides; Time Factors; Tyrosine | 2008 |
Toxicologic studies with alpha-methyltyrosine, an inhibitor of tyrosine hydroxylase.
Topics: Animals; Behavior, Animal; Blood Glucose; Blood Urea Nitrogen; Body Temperature; Body Weight; Brain Chemistry; Catecholamines; Enzymes; Female; Glycosuria; Hematuria; Hypothermia, Induced; Kidney; Kidney Diseases; Methyltyrosines; Organ Size; Polyuria; Proteinuria; Rats; Tyrosine; Water | 1967 |
On the renal tubular damage in hereditary tyrosinemia and on the formation of succinylacetoacetate and succinylacetone.
Topics: Acetoacetates; Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Child; Heptanoates; Homogentisic Acid; Humans; Infant; Keto Acids; Kidney Diseases; Kidney Tubules; Male; Phenylalanine; Proteinuria; Tyrosine | 1981 |
Protective effects of CGS 30440, a combined angiotensin-converting enzyme inhibitor and neutral endopeptidase inhibitor, in a model of chronic renal failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Creatinine; Cyclic GMP; Electrolytes; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Neprilysin; Protease Inhibitors; Proteinuria; Rats; Rats, Sprague-Dawley; Tyrosine | 1998 |
Effect of storage on phenylalanine and tyrosine measurements in whole-blood samples.
Topics: Adolescent; Blood Specimen Collection; Child; Child, Preschool; Humans; Infant; Phenylalanine; Proteinuria; Time Factors; Tyrosine | 2001 |
Nitric oxide inhibition enhances platelet aggregation in experimental anti-Thy-1 nephritis.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Immunohistochemistry; Isoantibodies; Kidney Glomerulus; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Aggregation; Proteinuria; Rats; Tyrosine | 2001 |
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.
Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetic Nephropathies; Female; Hydrogen Peroxide; Isoquinolines; Kidney; Lipid Peroxidation; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Proteinuria; Quinapril; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Superoxides; Tetrahydroisoquinolines; Tetrazoles; Tyrosine | 2002 |
Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker.
Topics: Albuminuria; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Genetic Predisposition to Disease; Hypertension; Kidney Glomerulus; Male; Phosphorylation; Proteinuria; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Platelet-Derived Growth Factor beta; Stroke; Tyrosine | 2002 |
Glomerular protein synthesis in proteinuric rats.
Topics: Amino Acids; Animals; Basement Membrane; Hydroxylation; Hydroxyproline; In Vitro Techniques; Kidney Glomerulus; Leucine; Male; Proline; Proteins; Proteinuria; Rats; Tyrosine | 1977 |
Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Acetoacetates; alpha-Fetoproteins; Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Child; Child, Preschool; Cyclohexanones; Erythrocytes; Heptanoates; Humans; Hydroxybenzoates; Infant; Kidney Tubules; Liver; Nitrobenzoates; Phenylalanine; Phosphates; Porphobilinogen Synthase; Proteinuria; Tyrosine | 1992 |
Serum protein turnover in the congenital nephrotic syndrome. Experimental studies with 3H-tyrosine and 131-I-proteins.
Topics: Albumins; Ascites; Blood Chemical Analysis; Blood Protein Electrophoresis; Blood Proteins; Edema; Feces; Female; gamma-Globulins; Hemoglobinometry; Humans; Immunoelectrophoresis; Infant; Iodine Isotopes; Male; Nephrotic Syndrome; Proteinuria; Serum Albumin; Serum Globulins; Tritium; Tyrosine | 1966 |
Thin-layer chromatographic screening of amino acids in plasma and urine of newborns.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Arginine; Blood Proteins; Chromatography, Thin Layer; Female; Glycine; Homocysteine; Humans; Indicators and Reagents; Infant, Newborn; Infant, Premature; Lysine; Methionine; Phenylalanine; Pregnancy; Proteinuria; Tyrosine; Ultrafiltration | 1974 |
[Letter: Red-staining of diapers by urine].
Topics: Alkaptonuria; Bedding and Linens; Humans; Infant; Porphyrins; Proteinuria; Tyrosine; Uric Acid; Urine | 1974 |
Selective malabsorption of vitamin B 12: report of a case with metabolic studies.
Topics: Alanine; Amino Acids; Anemia, Macrocytic; Child; Chromatography, Gas; Glycine; Hemoglobins; Histidine; Humans; Isoleucine; Leucine; Malabsorption Syndromes; Male; Malonates; Methionine; Proteinuria; Renal Tubular Transport, Inborn Errors; Reticulocytes; Serine; Taurine; Threonine; Tyrosine; Valine; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein.
Topics: Acidosis, Renal Tubular; Albuminuria; Amino Acid Metabolism, Inborn Errors; Cadmium Poisoning; Creatinine; Cystinosis; Diagnosis, Differential; Female; Glomerulonephritis; Hepatolenticular Degeneration; Humans; Immune Sera; Immunodiffusion; Kidney Glomerulus; Kidney Tubules; Laurence-Moon Syndrome; Male; Molecular Weight; Nephritis, Hereditary; Nephrotic Syndrome; Proteinuria; Serum Globulins; Tyrosine | 1969 |
Column chromatographic separations of amino acids, peptides, and protein in normal human urine.
Topics: Amino Alcohols; Carbohydrates; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Dipeptides; Glycosides; Humans; Hydrolysis; Hydroxylysine; Methods; Peptides; Phosphoric Acids; Proteinuria; Renal Aminoacidurias; Sulfuric Acids; Tyrosine; Urease | 1972 |