tyrosine has been researched along with Nerve Degeneration in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (11.27) | 18.7374 |
| 1990's | 6 (8.45) | 18.2507 |
| 2000's | 46 (64.79) | 29.6817 |
| 2010's | 9 (12.68) | 24.3611 |
| 2020's | 2 (2.82) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, J; Lin, WY; Liu, HP; Wu, BT | 1 |
| Dignon, GL; Fawzi, NL; Hart, AC; Lins, J; Mittal, J; Naik, MT; Perdikari, TM; Ryan, VH; Saueressig, CF | 1 |
| Cavallaro, S; D'Agata, V; D'Amico, AG; Federico, C; La Cognata, V; Maugeri, G; Morello, G; Rasà, DM; Saccone, S | 1 |
| Santa-Cruz, LD; Tapia, R | 1 |
| Archer, M; Bartlett, CA; Fitzgerald, M; Lam, M; Maghzal, GJ; O'Hare Doig, RL; Stocker, R | 1 |
| Collier, TJ; Kanaan, NM; Kordower, JH | 1 |
| Ashki, N; Bao, F; Hayes, KC | 1 |
| Doré, S; Wang, J | 1 |
| Carbery, T; Geddes, JW; Nasr, P | 1 |
| Chisu, V; Farina, V; Gadau, S; Lepore, G; Manca, P; Zedda, M | 1 |
| Dayton, RD; Klein, RL; Sunderland, JJ; Tainter, KH; Terry, TL; Vascoe, C | 1 |
| Alvarez, JM; Bombeiro, AL; Chadi, G; D'Império Lima, MR | 1 |
| Doverhag, C; Hagberg, H; Hedtjärn, M; Karlsson, A; Mallard, C; Poirier, F; Sävman, K | 1 |
| Abdelsaid, MA; Al-Gayyar, MM; Ali, TK; El-Remessy, AB; Matragoon, S; Pillai, BA | 1 |
| Babu, PP; Chaitanya, GV; Eeka, P | 1 |
| Feeney, MB; Schöneich, C | 1 |
| Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT | 1 |
| Dong, Y; Endo, T; Iguchi, F; Ito, J; Kim, TS; Lee, JE; Lee, SH; Naito, Y; Nakagawa, T; Yuki, K | 1 |
| Schmidt, WJ; Srinivasan, J | 1 |
| Camats, J; Campbell, IL; Giralt, M; Hadberg, H; Hidalgo, J; Molinero, A; Penkowa, M; Quintana, A; Rojas, S | 1 |
| Chiu, LY; Rameau, GA; Ziff, EB | 1 |
| Detloff, MR; Hall, ED; Johnson, K; Kupina, NC | 1 |
| Andreadis, A; Bhaskar, K; Do, LH; Fang, SM; Ksiezak-Reding, H; Lee, G; Litersky, JM; Sharma, VM; Thangavel, R; Van Hoesen, G | 1 |
| Bentura, ML; Castro-Blanco, S; Encinas, JM; Fernández, AP; Fernández-Vizarra, P; Martínez-Murillo, R; Muñoz, P; Rodrigo, J; Serrano, J | 1 |
| Iravani, MM; Jenner, P; Liu, L; Rose, S | 1 |
| Gupta, N; Kaufman, PL; Luthra, A; Weinreb, RN; Yücel, YH | 1 |
| Cribb, AE; Donaldson, MT; Dybdal, N; McFarlane, D; Miller, L | 1 |
| Craft, JM; Marks, A; Van Eldik, LJ; Watterson, DM | 1 |
| Andersen, JK; Atienza, JG; Di Monte, DA; Johnston, LC; McCormack, AL; Vu, S | 1 |
| Giasson, BI; Hodara, R; Ischiropoulos, H; Lee, VM; Lynch, DR; Mishizen-Eberz, AJ; Norris, EH; Trojanowski, JQ | 1 |
| Cui, L; Hutton, ML; Lee, G; Propst, JA; Vega, IE; Yen, SH | 1 |
| Halliwell, B; Hyun, DH; Jenner, P; Lee, M | 1 |
| Brundin, L; Danilov, A; Gahm, C; Holmin, S; Mathiesen, T; Wiklund, PN | 1 |
| Butterfield, DA; Cai, J; Klein, JB; Markesbery, WR; Merchant, M; Pierce, WM; Poon, HF; Sultana, R | 1 |
| Butterfield, DA; Calabrese, V; Coccia, R; De Marco, C; Joshi, G; Perluigi, M; Sultana, R | 1 |
| Deng, Y; Hall, ED; Mbye, LH; Singh, IN; Sullivan, PG | 1 |
| Jiang, H; Schacht, J; Sha, SH; Talaska, AE | 1 |
| Brundin, L; Gahm, C; Holmin, S; Mathiesen, T; Wiklund, PN | 1 |
| Höke, A; Jack, C; Lambrinos, GL; Melli, G; Ringkamp, M | 1 |
| Hall, ED; Rabchevsky, AG; Xiong, Y | 1 |
| Abdul, HM; Butterfield, DA | 1 |
| Deng, Y; Gao, X; Hall, ED; Thompson, BM | 1 |
| Bayir, H; Billiar, TR; Clark, RS; Huang, Z; Janesko-Feldman, K; Kagan, VE; Kochanek, PM; Rafikov, R; Vagni, V; Zhang, X | 1 |
| Akaike, A; Ariga, H; Iguchi-Ariga, SM; Inden, M; Inubushi, T; Kitamura, Y; Morikawa, S; Morita, M; Taira, T; Takata, K; Taniguchi, T; Tooyama, I; Yanagisawa, D | 1 |
| Ali, T; Aly, Z; Frossard, PM; Khealani, B; Saleheen, D | 1 |
| Aono, S; Hayakawa, M; Ida, M; Kakizawa, H; Kojima, S; Kuroda, Y; Maeda, H; Matsui, F; Nakanishi, K; Oohira, A; Saito, A; Sato, Y; Tokita, Y | 1 |
| Ali, TK; El-Remessy, AB; Liou, GI; Matragoon, S; Pillai, BA | 1 |
| Karp, HL; Reich, C; Soria, J; Tillotson, ML; Wood, JG | 1 |
| Beckman, JS; Chen, J; Conger, KA; Ye, YZ | 1 |
| Halliwell, B; Jenner, P; Kaur, H; Lyras, L | 1 |
| Leong, SK; Ng, YK; Xu, M | 1 |
| Caputi, A; Cattabeni, F; Cimino, M; Di Luca, M; Gardoni, F; Pastorino, L | 1 |
| Dantzer, R; Kelley, KW; Liu, Q; Tang, Q; VanHoy, RW; Venters, HD | 1 |
| Griffith, R; Soria, J; Wood, JG | 1 |
| Knight, KR; Liu, T; Tracey, DJ | 1 |
| Carrasco, J; Hadberg, H; Hidalgo, J; Molinero, A; Penkowa, M | 1 |
| Joe, E; Jou, I; Kang, J; Yang, M | 1 |
| Arimura, K; Eto, K; Fukuyama, N; Miyamoto, K; Moriguchi, S; Murao, K; Nakanishi, H; Osame, M; Wakamiya, J | 1 |
| Duff, K; La Francois, J; Matsuoka, Y; Picciano, M | 1 |
| Abe, K; Hayashi, T; Manabe, Y; Murakami, T; Shoji, M; Wang, JM; Warita, H | 1 |
| Espejo, C; Hidalgo, J; Martínez-Cáceres, EM; Montalban, X; Penkowa, M; Poulsen, CB | 1 |
| Bémeur, C; Butterworth, R; Hazell, AS; Montgomery, J; Ste-Marie, L | 1 |
| Bedecs, K; Lindegren, H; Ostlund, P; Pettersson, C | 1 |
| Nyback, H; Sedvall, G | 1 |
| Birkmayer, W; Danielczyk, W; Neumayer, E; Riederer, P | 1 |
| Creese, I; Iversen, SD | 1 |
| Agid, Y; Bouvet, D; Glowinski, J; Javoy, F | 1 |
| Descarries, L; Saucier, G | 1 |
| Austic, RE; Grau, CR | 1 |
| Bennett, T; Cobb, JL; Malmfors, T | 1 |
| Korochkin, LI; Korochkina, LS | 1 |
2 review(s) available for tyrosine and Nerve Degeneration
| Article | Year |
|---|---|
Tyrosine modifications in aging.
Topics: Aging; Atherosclerosis; Cataract; Humans; Nerve Degeneration; Oxidative Stress; Protein Processing, Post-Translational; Proteins; Structure-Activity Relationship; Tyrosine | 2012 |
Effects of neuroleptics on striatal dopamine synthesized from 14C-tyrosine.
Topics: Animals; Brain; Catecholamines; Chlorpromazine; Corpus Striatum; Dopamine; Electric Stimulation; In Vitro Techniques; Mice; Nerve Degeneration; Rats; Stimulation, Chemical; Tranquilizing Agents; Tyrosine | 1976 |
69 other study(ies) available for tyrosine and Nerve Degeneration
| Article | Year |
|---|---|
Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in
Topics: Animals; Dopaminergic Neurons; Drosophila; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mutation; Nerve Degeneration; Parkinson Disease; Tyrosine | 2023 |
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cytoplasmic Granules; Disease Models, Animal; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Heterogeneous-Nuclear Ribonucleoprotein Group F-H; Humans; Microtubule-Associated Proteins; Models, Molecular; Mutation; Nerve Degeneration; Neurodegenerative Diseases; Phosphorylation; Protein Conformation; Protein Domains; Tyrosine | 2021 |
Molecular mechanisms involved in the protective effect of pituitary adenylate cyclase-activating polypeptide in an in vitro model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cell Survival; Culture Media, Serum-Free; Cyclic AMP-Dependent Protein Kinases; ErbB Receptors; Matrix Metalloproteinase 2; Mice; Mitogen-Activated Protein Kinases; Motor Neurons; Mutation; Nerve Degeneration; Phosphorylation; Pituitary Adenylate Cyclase-Activating Polypeptide; Signal Transduction; Superoxide Dismutase-1; Tyrosine | 2019 |
Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Cell Death; Disease Models, Animal; Disease Progression; Lumbar Vertebrae; Male; Motor Activity; Motor Neurons; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Paralysis; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2014 |
Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration.
Topics: Analysis of Variance; Animals; Chromatography, Liquid; Disease Models, Animal; Ectodysplasins; Ethidium; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Guanine; Microscopy, Electron, Transmission; Mitochondria; Myelin Basic Protein; Nerve Degeneration; Optic Nerve Injuries; Oxidative Stress; Rats; Reactive Oxygen Species; Tandem Mass Spectrometry; Time Factors; Tyrosine | 2014 |
Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration.
Topics: Aging; Animals; Cytosol; Dopamine Plasma Membrane Transport Proteins; Fluorescent Antibody Technique; Immunohistochemistry; Macaca mulatta; Nerve Degeneration; Neurons; Substantia Nigra; Tyrosine; Ventral Tegmental Area; Vesicular Monoamine Transport Proteins | 2008 |
The peroxynitrite donor 3-morpholinosydnonimine induces reversible changes in electrophysiological properties of neurons of the guinea-pig spinal cord.
Topics: Action Potentials; Animals; Axons; Cell Membrane; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Guinea Pigs; Molsidomine; Nerve Degeneration; Neural Conduction; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Peroxynitrous Acid; Sodium Channels; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2008 |
Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage.
Topics: Analysis of Variance; Animals; Brain Edema; Calcium-Binding Proteins; Cerebral Hemorrhage; Cytochromes c; Disease Models, Animal; Encephalitis; Fluoresceins; Functional Laterality; Glial Fibrillary Acidic Protein; Granulocyte Colony-Stimulating Factor; Heme Oxygenase (Decyclizing); Interleukin-3; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Nerve Degeneration; Organic Chemicals; Recombinant Fusion Proteins; Recombinant Proteins; Spectrophotometry; Time Factors; Tyrosine | 2008 |
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity.
Topics: Adenosine Diphosphate; Animals; Corpus Striatum; Dizocilpine Maleate; Drug Interactions; Male; Memantine; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Nitro Compounds; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2009 |
D-glucose induces microtubular changes in C1300 neuroblastoma cell line through the incorporation of 3-nitro-L-tyrosine into tubulin.
Topics: Actins; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytoskeleton; Down-Regulation; Energy Metabolism; Glucose; Hyperglycemia; Mice; Microtubules; Nerve Degeneration; Neuroblastoma; Neurons; Oxidative Stress; Tubulin; Tyrosine | 2008 |
PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fluorine Radioisotopes; Genetic Vectors; Male; Nerve Degeneration; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics; tau Proteins; Time Factors; Transfection; Tyrosine | 2009 |
Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruzi.
Topics: Animals; Cells, Cultured; Chagas Disease; Disease Models, Animal; Female; Host-Parasite Interactions; Immunity, Innate; Inflammation Mediators; Interferon-gamma; Interleukin-12 Subunit p40; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelitis; Nerve Degeneration; Nerve Growth Factors; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Paraplegia; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Spinal Cord; Trypanosoma cruzi; Tyrosine | 2010 |
Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Encephalitis; Female; Galectin 3; Gliosis; Hypoxia-Ischemia, Brain; Inflammation Mediators; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Degeneration; Tyrosine | 2010 |
Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected].
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Catechin; Cell Line; In Situ Nick-End Labeling; Male; Nerve Degeneration; Nerve Growth Factor; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Retina; Retinal Ganglion Cells; RNA, Small Interfering; Tyrosine | 2011 |
Proteolytic breakdown of cytoskeleton induces neurodegeneration during pathology of murine cerebral malaria.
Topics: Animals; Blotting, Western; Calpain; Caspase 1; Cytoskeletal Proteins; Cytoskeleton; Epoxy Compounds; Fluorescent Antibody Technique; Immunohistochemistry; Immunoprecipitation; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Nerve Degeneration; Peptide Hydrolases; Plasmodium berghei; Proteolysis; Receptor Cross-Talk; Tyrosine | 2011 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
A novel model for rapid induction of apoptosis in spiral ganglions of mice.
Topics: Animals; Apoptosis; Cell Death; Cisplatin; Disease Models, Animal; In Situ Nick-End Labeling; Intermediate Filament Proteins; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Peripherins; Peroxynitrous Acid; Spiral Ganglion; Tyrosine | 2003 |
Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Behavior, Animal; Benzylamines; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Interactions; Haloperidol; Hippocampus; Homovanillic Acid; Hypothalamus; Locus Coeruleus; Male; Medial Forebrain Bundle; Nerve Degeneration; Neurotoxins; Norepinephrine; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin; Substantia Nigra; Thalamus; Tyrosine | 2003 |
Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide.
Topics: 6-Aminonicotinamide; Angiogenesis Inducing Agents; Animals; Apoptosis; Astrocytes; Brain Stem; Cell Count; Central Nervous System; Cytokines; Disease Models, Animal; Gene Targeting; Glial Fibrillary Acidic Protein; Growth Substances; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Lymphocytes; Macrophages; Malondialdehyde; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Nerve Degeneration; Oxidative Stress; Staining and Labeling; Stem Cells; Teratogens; Tyrosine | 2003 |
NMDA receptor regulation of nNOS phosphorylation and induction of neuron death.
Topics: Animals; Apoptosis; Calcineurin; Calcineurin Inhibitors; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Situ Nick-End Labeling; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphoprotein Phosphatases; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2003 |
Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Disease Models, Animal; Image Processing, Computer-Assisted; Immunohistochemistry; Lipid Peroxidation; Male; Mice; Nerve Degeneration; Peroxynitrous Acid; Proteins; Time Factors; Tyrosine | 2004 |
Phosphorylation of tau by fyn: implications for Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Antibodies, Monoclonal; Antibody Affinity; Antibody Specificity; Brain; Cell Line; Chlorocebus aethiops; Humans; Immunohistochemistry; Mice; Microtubules; Nerve Degeneration; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; tau Proteins; Tyrosine | 2004 |
Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cell Death; Humans; Immunohistochemistry; Middle Aged; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyramidal Cells; Temporal Lobe; Tyrosine | 2004 |
Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration.
Topics: Animals; Functional Laterality; Guanidines; Immunohistochemistry; Inflammation; Interneurons; Male; Motor Activity; N-Methylaspartate; NADPH Dehydrogenase; Neostriatum; Nerve Degeneration; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 2004 |
Oxidative injury by peroxynitrite in neural and vascular tissue of the lateral geniculate nucleus in experimental glaucoma.
Topics: Animals; Endothelium, Vascular; Geniculate Bodies; Glaucoma; Immunohistochemistry; Macaca fascicularis; Macaca mulatta; Nerve Degeneration; Neurons; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2005 |
Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction.
Topics: alpha-Synuclein; Animals; Blotting, Western; Chronic Disease; Dopamine; Horse Diseases; Horses; Immunohistochemistry; Nerve Degeneration; Nerve Tissue Proteins; Nitrogen; Oxidative Stress; Pituitary ACTH Hypersecretion; Pituitary Gland; Synucleins; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.
Topics: Amyloid beta-Peptides; Animals; Biomarkers; Brain; Disease Models, Animal; Encephalitis; Genetic Predisposition to Disease; Gliosis; Humans; Injections, Intraventricular; Mice; Mice, Knockout; Mice, Transgenic; Nerve Degeneration; Nerve Growth Factors; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine | 2005 |
Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.
Topics: Aldehydes; Analysis of Variance; Animals; Cell Count; Dopamine; Drug Administration Schedule; Ferritins; Herbicides; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Oxidative Stress; Paraquat; Promoter Regions, Genetic; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Topics: alpha-Synuclein; Calpain; Chymotrypsin; Humans; Hydrolysis; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Parkinson Disease; Peptide Fragments; Peroxynitrous Acid; Recombinant Proteins; Solubility; Synucleins; Tyrosine | 2005 |
Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.
Topics: Aging; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Female; Humans; Inclusion Bodies; Male; Mice; Mice, Transgenic; Mutation, Missense; Nerve Degeneration; Neurons; Phosphorylation; Protein Isoforms; tau Proteins; Tauopathies; Tyrosine; Up-Regulation | 2005 |
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases | 2005 |
Reduced neuronal injury after treatment with NG-nitro-L-arginine methyl ester (L-NAME) or 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) following experimental brain contusion.
Topics: Animals; Apoptosis; Benzenesulfonates; Brain; Brain Injuries; Cell Survival; Drug Combinations; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Immunohistochemistry; In Situ Nick-End Labeling; Male; Nerve Degeneration; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organic Chemicals; Rats; Rats, Sprague-Dawley; Tyrosine | 2005 |
Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; ATP Synthetase Complexes; Carbonic Anhydrase II; Female; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); Hippocampus; Humans; Male; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Oxidation-Reduction; Oxidative Stress; Phosphopyruvate Hydratase; Phosphorylation; Proteomics; Tyrosine; Voltage-Dependent Anion Channel 1 | 2006 |
In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Brain; Bridged-Ring Compounds; Disease Models, Animal; Free Radicals; Gerbillinae; Lipid Peroxidation; Male; Nerve Degeneration; Neurons; Norbornanes; Oxidative Stress; Peptide Fragments; Reactive Oxygen Species; Synaptosomes; Thiocarbamates; Thiones; Type C Phospholipases; Tyrosine | 2006 |
Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy.
Topics: Animals; Blotting, Northern; Brain Hemorrhage, Traumatic; Calpain; Cytoskeleton; Male; Membrane Lipids; Membrane Proteins; Mice; Microscopy, Electron; Mitochondria; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2006 |
Oxidative imbalance in the aging inner ear.
Topics: Aging; Aldehydes; Animals; Apoptosis Inducing Factor; Biomarkers; Cochlea; Free Radicals; Hair Cells, Auditory; Male; Mice; Mice, Inbred CBA; Nerve Degeneration; Neurons, Afferent; Organ of Corti; Oxidative Stress; Spiral Ganglion; Superoxide Dismutase; Tyrosine | 2007 |
Neuroprotection by selective inhibition of inducible nitric oxide synthase after experimental brain contusion.
Topics: Animals; Apoptosis; Brain Injuries; Cell Survival; Disease Models, Animal; Female; Lysine; Nerve Degeneration; Neurons; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cells, Cultured; Dose-Response Relationship, Drug; Drug Carriers; Erythropoietin; Female; Ganglia, Spinal; Glycerol; Humans; Injections, Intraperitoneal; Mice; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Paclitaxel; Recombinant Proteins; Tubulin; Tyrosine | 2006 |
Role of peroxynitrite in secondary oxidative damage after spinal cord injury.
Topics: Aldehydes; Animals; Biomarkers; Calcium Signaling; Calpain; Disease Progression; Female; Free Radical Scavengers; Free Radicals; Lipid Peroxidation; Nerve Degeneration; Nitric Oxide; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spectrin; Spinal Cord Injuries; Time Factors; Tyrosine; Up-Regulation | 2007 |
Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
Topics: Acetylcarnitine; Aldehydes; Alzheimer Disease; Animals; Apoptosis; Cell Survival; Cerebral Cortex; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Lipid Peroxidation; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Thioctic Acid; Tyrosine | 2007 |
Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Calcium; Calpain; Cerebral Cortex; Cytoskeleton; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Spectrin; Time Factors; Tissue Distribution; Tyrosine | 2007 |
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.
Topics: Adolescent; Adult; Aged; Animals; Brain; Brain Injuries; Chemotaxis, Leukocyte; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nerve Degeneration; Nitrates; Nitric Oxide Synthase Type I; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2007 |
DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats.
Topics: Animals; Behavior, Animal; Cerebral Infarction; Humans; Intracellular Signaling Peptides and Proteins; Magnetic Resonance Imaging; Nerve Degeneration; Oncogene Proteins; Protein Deglycase DJ-1; Rats; Reactive Oxygen Species; Reperfusion Injury; Tyrosine | 2008 |
Novel mutation in the PANK2 gene leads to pantothenate kinase-associated neurodegeneration in a Pakistani family.
Topics: Adolescent; Amino Acid Substitution; Basal Ganglia; Child; Cysteine; DNA Mutational Analysis; Genes, Recessive; Homozygote; Humans; Iron; Male; Mutation; Nerve Degeneration; Pakistan; Phosphotransferases (Alcohol Group Acceptor); Tyrosine | 2007 |
A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Caspase 3; Cell Death; Cell Survival; Chondroitin Sulfates; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neocortex; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Polyelectrolytes; Polymers; Pregnancy; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes.
Topics: Animals; Cadaver; Cell Death; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Lipid Peroxidation; Middle Aged; Nerve Degeneration; Nerve Growth Factor; Optic Nerve; Peroxynitrous Acid; Rats; Reference Values; Retinal Ganglion Cells; RNA, Messenger; Streptozocin; Tyrosine | 2008 |
Microglial tyrosine phosphorylation systems in normal and degenerating brain.
Topics: Animals; Blotting, Western; Brain Chemistry; Humans; Immunohistochemistry; Microglia; Nerve Degeneration; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Tyrosine; Up-Regulation | 1994 |
The interactions of nitric oxide with oxygen radicals and scavengers in cerebral ischemic injury.
Topics: Animals; Brain Ischemia; Free Radical Scavengers; Nerve Degeneration; Nitric Oxide; Oxygen; Tyrosine | 1996 |
Artefacts in HPLC detection of 3-nitrotyrosine in human brain tissue.
Topics: Artifacts; Brain; Cadaver; Chromatography, High Pressure Liquid; Humans; Nerve Degeneration; Nervous System Diseases; Reference Values; Tyrosine | 1998 |
Induction of microglial reaction and expression of nitric oxide synthase I in the nucleus dorsalis and red nucleus following lower thoracic spinal cord hemisection.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Functional Laterality; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Male; Membrane Glycoproteins; Microglia; Nerve Degeneration; Neurons; Nitric Oxide Synthase; Rats; Rats, Wistar; Red Nucleus; Spinal Cord; Spinal Cord Injuries; Tegmentum Mesencephali; Tyrosine | 1998 |
CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enzyme Activation; Female; Gene Expression; Hippocampus; In Situ Hybridization; Long-Term Potentiation; Methylazoxymethanol Acetate; Nerve Degeneration; Neurons; Organ Culture Techniques; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serine; Synapses; Threonine; Tyrosine | 1999 |
A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide.
Topics: Animals; Cell Survival; Cells, Cultured; DNA Fragmentation; Enzyme Activation; Flow Cytometry; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Nerve Degeneration; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Regulation of microglial tyrosine phosphorylation in response to neuronal injury.
Topics: Animals; Anterior Horn Cells; Benzoquinones; Denervation; Enzyme Inhibitors; Ganglia, Spinal; Lactams, Macrocyclic; Microglia; Nerve Degeneration; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Ricin; Rifabutin; Sciatic Nerve; Tyrosine | 2000 |
Hyperalgesia due to nerve injury-role of peroxynitrite.
Topics: Animals; Hyperalgesia; Hyperthermia, Induced; Immunohistochemistry; Male; Nerve Compression Syndromes; Nerve Crush; Nerve Degeneration; Neuralgia; Nitrates; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Rats, Wistar; Tyrosine; Uric Acid | 2000 |
Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice.
Topics: Animals; Apoptosis; Astrocytes; Caspase 1; Caspase 3; Caspases; DNA, Single-Stranded; Epilepsy; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Granulocyte-Macrophage Colony-Stimulating Factor; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Malondialdehyde; Metallothionein; Metallothionein 3; Mice; Mice, Inbred Strains; Mice, Knockout; Microglia; Nerve Degeneration; Nerve Tissue Proteins; NF-kappa B; Nitrogen; Oxidative Stress; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Seizures; Superoxide Dismutase; Tyrosine; Zinc | 2000 |
Identification of protein kinase C isoforms involved in interferon-gamma-induced expression of inducible nitric oxide synthase in murine BV2 microglia.
Topics: Animals; Cell Line; Encephalitis; Interferon-gamma; Mice; Microglia; Nerve Degeneration; Nitric Oxide Synthase; Phosphorylation; Protein Isoforms; Protein Kinase C; Tyrosine | 2001 |
Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Glycoproteins; Mercury Poisoning, Nervous System; Methylmercury Compounds; Nerve Degeneration; Neurons; Nitrates; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Central Nervous System Diseases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radicals; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Interneurons; Motor Neurons; Nerve Degeneration; Neurons; Neurotoxins; Nitrates; Nitric Oxide Donors; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spinal Cord; Tyrosine | 2001 |
Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.
Topics: Animals; Apoptosis; Encephalomyelitis, Autoimmune, Experimental; Gliosis; In Situ Nick-End Labeling; Interleukin-1; Interleukin-6; Macrophages; Malondialdehyde; Metallothionein; Mice; Mice, Inbred Strains; Mice, Knockout; Microglia; Nerve Degeneration; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia.
Topics: Animals; Blood Vessels; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Hyperglycemia; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Nerve Degeneration; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2001 |
Altered insulin receptor processing and function in scrapie-infected neuroblastoma cell lines.
Topics: Animals; Blotting, Western; Cell Division; Gene Expression; Hypoglycemic Agents; Insulin; Iodine Radioisotopes; Mitogen-Activated Protein Kinase 1; Nerve Degeneration; Neuroblastoma; Phosphorylation; Prions; Receptor, Insulin; Scrapie; Tumor Cells, Cultured; Tyrosine | 2001 |
Dopaminergic supersensitivity in parkinsonism.
Topics: Aged; Benzyl Compounds; Brain; Brain Chemistry; Dopamine; Drug Therapy, Combination; Female; Humans; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Nerve Degeneration; Norepinephrine; Parkinson Disease; Psychoses, Substance-Induced; Serotonin; Tryptophan; Tyrosine | 1975 |
Behavioral correlates of dopaminergic supersensitivity.
Topics: Animals; Animals, Newborn; Apomorphine; Behavior; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxydopamines; Hypothalamus; Levodopa; Motor Activity; Nerve Degeneration; Rats; Receptors, Drug; Stereotyped Behavior; Substantia Nigra; Tranylcypromine; Tyrosine | 1975 |
In vivo estimation of tyrosine hydroxylation in the dopaminergic terminals of the rat neostriatum.
Topics: Animals; Corpus Striatum; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Hydroxylation; Male; Methods; Methyltyrosines; Nerve Degeneration; Rats; Receptors, Drug; Time Factors; Tranquilizing Agents; Tritium; Tyrosine; Urea; Water | 1974 |
Disappearance of the locus coeruleus in the rat after intraventricular 6-hydroxdopamine.
Topics: Animals; Brain Stem; Cerebral Ventricles; Dihydroxyphenylalanine; Dopamine; Male; Microscopy, Fluorescence; Nerve Degeneration; Neurons; Norepinephrine; Rats; Sympathetic Nervous System; Tritium; Tyrosine | 1972 |
Degeneration of the eyes and central nervous system of chick embros subjected to phenylalanine or tyrosine deficiency.
Topics: Animals; Autoradiography; Carbon Isotopes; Cell Nucleus; Central Nervous System; Chick Embryo; Culture Media; Eye; Leucine; Microscopy, Electron; Nerve Degeneration; Nutritional Requirements; Phenylalanine; Pigments, Biological; Retinal Degeneration; Tritium; Tyrosine | 1971 |
Fluorescence histochemical observations on Auerbach's plexus and the problem of the inhibitory innervation of the gut.
Topics: Animals; Chickens; Digestive System; Epinephrine; Fluorescence; Histocytochemistry; Myenteric Plexus; Nerve Degeneration; Nerve Endings; Nerve Regeneration; Neurons; Phenethylamines; Reserpine; Tyrosine; Vinblastine | 1971 |
The influence of actinomycin on the development of brain cortex in rats in postnatal ontogenesis.
Topics: Animals; Animals, Newborn; Brain Mapping; Carbon Isotopes; Cell Differentiation; Cerebral Cortex; Dactinomycin; DNA; Nerve Degeneration; Nerve Regeneration; Nerve Tissue Proteins; Neurons; Photomicrography; Rats; Rats, Inbred Strains; RNA; Tritium; Tyrosine | 1971 |