tyrosine has been researched along with Myeloproliferative Disorders in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baccarini, M; Baumgartner, C; Catalanotti, F; Jesenberger, V; Reyes, G; Zmajkovicova, K | 1 |
| Aifantis, I; Gough, DJ; Levy, DE; Lobry, C; Marié, IJ | 1 |
| Boggon, TJ; Chen, J; Dong, S; Elf, S; Gu, TL; Guo, A; Hanauer, A; Hitosugi, T; Kang, S; Karsenty, G; Khoury, HJ; Lee, BH; Lonial, S; Lythgoe, K; Roesel, JL; Ruan, H; Taunton, J; Williams, IR | 1 |
| Constantinescu, SN; Elliott, J; Green, AR; Johnston, JA; McMullin, MF; Nahlik, K; Scott, LM; Suessmuth, Y | 1 |
| Chaligné, R; Constantinescu, SN; Giraudier, S; Goss, V; Lee, KA; Pecquet, C; Poirel, HA; Polakiewicz, RD; Rush, J; Scheiff, JM; Staerk, J; Vainchenker, W; Van Hees, J; Zhang, X | 1 |
| Boissinot, M; Cleyrat, C; Girodon, F; Harousseau, JL; Hermouet, S; Issa, JP; Jelinek, J; Ponge, T | 1 |
| Ando, T; Kawakami, T; Kawakami, Y; Wang, HY; Xiao, W | 1 |
| Funakoshi-Tago, M; Kamishimoto, J; Kasahara, T; Tago, K | 1 |
| Anderhub, S; Bachmann, J; Bochtler, T; Ho, AD; Kirsch, M; Klingmüller, U; Krämer, A; Maier, B | 1 |
| Kapur, R; Ma, P; Mali, RS; Martin, H; Ramdas, B; Sims, E | 1 |
| Bunting, KD; Chan, RJ; Chatterjee, A; Craig, AW; Feng, GS; Ghosh, J; He, Y; Kapur, R; Li, S; Ma, P; Mali, RS; Martin, H; Munugalavadla, V; Nabinger, S; Ramdas, B; Sandusky, G; Sharma, N; Sims, E; Zeng, LF; Zhang, ZY | 1 |
| Hutchison, RE; Mohi, G; Yan, D | 1 |
| Cheng, D; McLaughlin, J; Robb, L; Shannon, K; Witte, ON; Wong, S | 1 |
| Cheng, D; McLaughlin, J; Shokat, KM; Witte, ON; Wong, S; Zhang, C | 1 |
| Gilliland, DG; Tefferi, A | 1 |
| Giese, N; Gilliland, DG; Lee, BH; Okabe, R; Rocnik, JL; Schenkein, DP; Yu, JC | 1 |
| Gilliland, DG; Ihle, JN | 1 |
| Bei, L; Eklund, EA; Horvath, E; Huang, W; Konieczna, I; Lindsey, S; Platanias, L; Saberwal, G; Wang, H | 1 |
| Hankins, WD; Moliterno, AR; Spivak, JL | 1 |
| Abdul-Rauf, M; Cooper, C; Cross, NC; Demiroglu, A; Heath, C; Shipley, J; Smedley, D | 1 |
| Gross, AW; Ren, R; Subrahmanyam, R; Wong, R; Zhang, X | 1 |
1 review(s) available for tyrosine and Myeloproliferative Disorders
| Article | Year |
|---|---|
Jak2: normal function and role in hematopoietic disorders.
Topics: Gene Expression Regulation, Neoplastic; Hematologic Neoplasms; Humans; Janus Kinase 2; Models, Molecular; Mutation; Myeloproliferative Disorders; Phosphorylation; Protein Structure, Tertiary; Receptors, Cytokine; Signal Transduction; Translocation, Genetic; Tyrosine | 2007 |
20 other study(ies) available for tyrosine and Myeloproliferative Disorders
| Article | Year |
|---|---|
MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autoimmune Diseases; Cell Adhesion Molecules; Cell Death; Cell Membrane; Chlorocebus aethiops; COS Cells; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Genotype; Guanylate Kinases; Lymphocyte Activation; Lymphocytes; Male; MAP Kinase Kinase 1; Membrane Proteins; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Myeloproliferative Disorders; Phenotype; Phosphatidylinositol Phosphates; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA Interference; Self Tolerance; Signal Transduction; Time Factors; Transfection; Tyrosine | 2013 |
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
Topics: Alleles; Animals; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; Myeloid Cells; Myeloproliferative Disorders; Phosphorylation; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Serine; STAT3 Transcription Factor; Stem Cells; Tyrosine | 2014 |
Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
Topics: Animals; Binding Sites; Bone Marrow Transplantation; Hematopoiesis; Mice; Myeloproliferative Disorders; Phosphorylation; Protein Binding; Receptor, Fibroblast Growth Factor, Type 3; Ribosomal Protein S6 Kinases, 90-kDa; Tyrosine | 2009 |
SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases.
Topics: Animals; Biomarkers, Tumor; Cell Line; Cell Proliferation; Exons; Humans; Janus Kinase 2; Mice; Mutation; Myeloproliferative Disorders; Phosphorylation; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes; Tyrosine | 2009 |
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Line; Cell Proliferation; Humans; Immunoblotting; Janus Kinase 2; Mice; Mutation; Myeloproliferative Disorders; Phosphoproteins; Phosphorylation; Precursor Cells, B-Lymphoid; Primary Myelofibrosis; Receptors, Thrombopoietin; Transfection; Tyrosine | 2010 |
JAK2 mutation and disease phenotype: a double L611V/V617F in cis mutation of JAK2 is associated with isolated erythrocytosis and increased activation of AKT and ERK1/2 rather than STAT5.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Animals; B-Lymphocytes; Base Sequence; Blotting, Western; Case-Control Studies; Cell Line; Colony-Forming Units Assay; Female; Genotype; Humans; Janus Kinase 2; Mice; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; Mutation; Myeloproliferative Disorders; Phenotype; Phosphorylation; Polycythemia; Polymerase Chain Reaction; Proto-Oncogene Proteins c-akt; STAT5 Transcription Factor; Thrombosis; Tyrosine; Young Adult | 2010 |
Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.
Topics: Animals; Female; Hematopoietic Stem Cells; Humans; Immunoblotting; Immunoprecipitation; Inflammation; Janus Kinase 2; Leukemia, Myelomonocytic, Chronic; Lung Diseases; Male; Mice; Mice, Inbred C57BL; Myeloproliferative Disorders; Phenotype; Phospholipase C beta; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Signal Transduction; src-Family Kinases; STAT5 Transcription Factor; Tyrosine | 2010 |
Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation.
Topics: Amino Acid Substitution; Animals; bcl-X Protein; Cell Transformation, Neoplastic; Chromones; CREB-Binding Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Janus Kinase 2; Mice; Mice, Nude; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Myeloproliferative Disorders; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Point Mutation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Erythropoietin; Tyrosine | 2011 |
Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Centrosome; Chronic Disease; Humans; Myeloproliferative Disorders; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Recombinant Fusion Proteins; Tyrosine | 2012 |
Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease.
Topics: Animals; Blotting, Western; Bone Marrow Transplantation; Cell Proliferation; Cell Transformation, Neoplastic; Extracellular Signal-Regulated MAP Kinases; Mice; Mice, Inbred C57BL; Mutation; Myeloproliferative Disorders; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Signal Transduction; STAT5 Transcription Factor; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tyrosine | 2012 |
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Topics: Animals; Apoptosis; Blotting, Western; Bone Marrow Transplantation; Cell Proliferation; Cell Transformation, Neoplastic; Class Ia Phosphatidylinositol 3-Kinase; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Immunoprecipitation; Integrases; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutation; Myeloproliferative Disorders; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-kit; Signal Transduction; Survival Rate; Tyrosine | 2012 |
Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice.
Topics: Animals; Apoptosis; Blotting, Western; Bone Marrow Cells; Bone Marrow Transplantation; Cell Line; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Enzyme Activation; Flow Cytometry; HEK293 Cells; Humans; Janus Kinase 2; Mice; Mice, Inbred BALB C; Mutation, Missense; Myeloproliferative Disorders; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Signal Transduction; STAT5 Transcription Factor; Tyrosine | 2012 |
IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease.
Topics: Animals; Genes, abl; Mice; Mice, Inbred C57BL; Myeloproliferative Disorders; Phosphorylation; Receptors, Interleukin-3; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrosine; Up-Regulation | 2003 |
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
Topics: Apoptosis; B-Lymphocytes; Benzamides; Cell Cycle; Cell Line; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Enzymologic; Humans; Imatinib Mesylate; Mutation; Myeloproliferative Disorders; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Tyrosine | 2004 |
JAK2 in myeloproliferative disorders is not just another kinase.
Topics: Alleles; Animals; Bone Marrow Cells; Cell Lineage; Cell Proliferation; Cytoplasm; DNA; DNA Mutational Analysis; Erythrocytes; Erythropoietin; Homozygote; Humans; Janus Kinase 2; Mice; Mutation; Myelodysplastic Syndromes; Myeloproliferative Disorders; Phenotype; Phosphorylation; Phosphotransferases; Point Mutation; Polycythemia; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Sequence Analysis, DNA; T-Lymphocytes; Tyrosine; Up-Regulation | 2005 |
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Myeloproliferative Disorders; Protein Structure, Tertiary; Signal Transduction; STAT5 Transcription Factor; Tyrosine | 2006 |
Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia.
Topics: Animals; Apoptosis; Cell Differentiation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interferon Regulatory Factors; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Myeloproliferative Disorders; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Transcription, Genetic; Tyrosine; U937 Cells | 2008 |
Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Female; Humans; Male; Megakaryocytes; Middle Aged; Myeloproliferative Disorders; Neoplasm Proteins; Phosphorylation; Polycythemia Vera; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Thrombopoietin; Signal Transduction; Thrombin; Thrombopoietin; Tyrosine | 1998 |
ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5.
Topics: Animals; Blotting, Western; Cell Line; COS Cells; Cytoplasm; DNA-Binding Proteins; Fluorescent Antibody Technique; Growth Substances; Humans; Interleukin-3; Mice; Milk Proteins; Myeloproliferative Disorders; Phosphorylation; Precipitin Tests; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Recombinant Fusion Proteins; Recombination, Genetic; Signal Transduction; STAT1 Transcription Factor; STAT5 Transcription Factor; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Tyrosine | 1999 |
The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Binding Sites; Bone Marrow Transplantation; Cell Line; DNA Primers; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Mice; Myeloproliferative Disorders; Protein Structure, Tertiary; Proteins; Transduction, Genetic; Tyrosine | 2001 |