tyrosine and Leukemia, Myeloid, Acute

tyrosine has been researched along with Leukemia, Myeloid, Acute in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (15.69)	18.7374
1990's	7 (13.73)	18.2507
2000's	23 (45.10)	29.6817
2010's	10 (19.61)	24.3611
2020's	3 (5.88)	2.80

Authors

Authors	Studies
Blacklow, SC; Franciosa, G; Jensen, LJ; Locard-Paulet, M; Olsen, JV; Pfeiffer, A; Piga, I; Reckzeh, K; Theilgaard-Mönch, K; Vemulapalli, V	1
Brzozowski, JS; Dun, MD; Humphrey, SJ; Kahl, RGS; Miller, K; Murray, HC; Smith, ND; Verrills, NM	1
AlQahtany, FS; AlSalhi, MS; Devanesan, S; Farhat, KH; Masilamani, V	1
Duyster, J; Götze, KS; Hengst, L; Jäkel, H; Nachbaur, D; Peschel, I; Podmirseg, SR; Sill, H; Taschler, M	1
Baer, MR; Burcu, M; Linn, DE; Natarajan, K; Qiu, Y; Xie, Y	1
Bluteau, D; Espasandin, YR; Glembotsky, AC; Goette, NP; Heller, PG; Korin, L; Laguens, RP; Lev, PR; Marin Oyarzun, CP; Marta, RF; Molinas, FC; Raslova, H	1
Beck, J; Bohnenberger, H; Braun, H; Bug, G; Corso, J; Cremer, A; Döbele, C; Mohr, S; Münch, S; Oellerich, MF; Oellerich, T; Perske, C; Schütz, E; Serve, H; Urlaub, H; Wicht, J	1
Chougule, RA; Kazi, JU; Li, T; Moharram, SA; Rönnstrand, L; Su, X; Sun, J; Zhao, H	1
Avalos, BR; Copelan, A; Hunter, MG; Link, DC; Loveland, M; McLemore, M	1
Bei, L; Eklund, EA; Horvath, E; Huang, W; Konieczna, I; Lindsey, S; Saberwal, G; Wang, H	1
Khan, R; Liu, T; Masson, K; Rönnstrand, L; Sun, J	1
Nakaseko, C; Onoda, M; Saito, Y; Yokota, A	1
Downing, JR	1
Berchuck, JE; Carr, SA; Carroll, M; Clauser, K; Davis, TN; DeAngelo, DJ; Galinsky, I; Golub, TR; Hahn, CK; Hahn, WC; Kakoza, RM; Kung, AL; Root, DE; Ross, KN; Ross, L; Schinzel, AC; Silver, SJ; Stegmaier, K; Stone, RM	1
Blau, W; Bobrich, M; Brobeil, A; Graf, M; Kruchten, A; Oeschger, S; Rummel, M; Steger, K; Wimmer, M	1
De Lutiis, MA; Felaco, M; Grilli, A; Marrone, A; Patruno, A; Pesce, M; Reale, M; Speranza, L	1
Adamia, S; Barrett, R; Daley, JF; Fox, E; Frank, D; Griffin, JD; Nelson, E; Ray, A; Sattler, M; Weisberg, E; Zhang, C	1
Bergholz, U; Ding, LW; Gery, S; Gueller, S; Kazi, JU; Koeffler, HP; Koren-Michowitz, M; Lin, DC; Rönnstrand, L; Stocking, C; Tabayashi, T; Yin, T	1
Altucci, L; Benedetti, R; Carafa, V; Conte, M; de Lera, AR; García-Rodríguez, J; Gronemeyer, H; Nebbioso, A; Pereira, R; Pérez-Rodríguez, S; Rodríguez-Barrios, F; Stuhldreier, M; Stunnenberg, HG	1
Blake, TJ; Brown, AL; Gonda, TJ; Kogan, SC; Le Beau, MM; Phan, VT; Shultz, DB; Truong, BT	1
Asano, S; Irie, M; Kamihira, S; Kawashima, T; Kitamura, T; Kumagai, H; Murata, K; Nakajima, H; Nosaka, T; Shibuya, M; Suzu, S; Tamitsu, K	1
Akiyama, H; Emi, N; Hirose, Y; Iwai, M; Kiyoi, H; Kodera, Y; Kuriyama, K; Miyawaki, S; Motoji, T; Naoe, T; Ninomiya, M; Nishimura, M; Ohno, R; Ozeki, K; Shimazaki, C; Shinagawa, K; Takeshita, A; Ueda, R	1
Aarts, LH; Gits, J; Heijmans-Antonissen, C; Touw, IP; van de Geijn, GJ	1
Breitenbuecher, F; Choudhary, CR; Cohen, PS; Ehninger, G; Estey, E; Feldman, E; Fischer, T; Giles, F; Gratwohl, A; Gschaidmeier, H; Huber, C; Kasper, S; Kindler, T; Klimek, V; Mueller-Tidow, C; Nimer, SD; Schiller, G; Serve, H	1
Bernstein, ID; Cooper, JA; Kamikura, DM; Raden, BW; Walter, RB	1
Cummings, CL; Drachman, JG; Gandhi, MJ; Glembotsky, AC; Heller, PG; Kornblihtt, LI; Marta, RF; Molinas, FC; Pirola, CJ	1
Bagrintseva, K; Ellwart, JW; Hiddemann, W; Hopfner, KP; Reindl, C; Schnittger, S; Spiekermann, K; Vempati, S; Wenig, K	1
Giese, N; Gilliland, DG; Lee, BH; Okabe, R; Rocnik, JL; Schenkein, DP; Yu, JC	1
Basic, I; Chandra, J; Giles, F; Golemovic, M; Kantarjian, H; Manshouri, T; Orsolic, N; Quintás-Cardama, A; Scappini, B; Verstovsek, S	1
Anensen, N; Bruserud, O; Børresen-Dale, AL; Gjertsen, BT; Hovland, R; Irish, JM; Nolan, GP; Skavland, J	1
Bei, L; Eklund, EA; Horvath, E; Huang, W; Konieczna, I; Lindsey, S; Platanias, L; Saberwal, G; Wang, H	1
Coates, PJ; Lorimore, SA; Robinson, JI; Wright, EG	1
Arima, F; Iwasaki, H; Kubota, A; Niho, Y; Ohno, Y; Okamura, S; Otsuka, T; Shimoda, K	1
Hanazono, Y; Hirai, H; Iki, S; Inuo, EK; Kitagawa, S; Mimura, T; Minoda, S; Urabe, A; Yagisawa, M; Yuo, A	1
Clarkson, B; Strife, A; Wisniewski, D	1
Hagiwara, S; Miwa, A; Nagai, M; Soda, Y; Takaku, F; Takezako, N; Togawa, A; Yuo, A	1
Schelen, AM; Touw, IP; van Aesch, YM; Ward, AC	1
Aster, JC; Cain, D; Gilliland, DG; Kutok, J; Liu, Q; Schwaller, J; Williams, IR	1
Balaian, L; Ball, ED	1
Eggen, BJ; Kruijer, W; Schuringa, JJ; Vellenga, E; Wierenga, AT	1
Deguchi, K; Gilliland, DG	1
Alai, M; Barbacid, M; Bustelo, XR; Cutler, RL; Krystal, G; Mui, AL	1
Griffin, JD; Ikeda, H; Ishikawa, J; Kanakura, Y; Kanayama, Y; Kitayama, H; Kuriu, A; Tamaki, T; Tarui, S; Yonezawa, T	1
Frank, DA; Sartorelli, AC	3
Esumi, N; Hibi, S; Imashuku, S; Kodo, N; Morioka, Y; Todo, S	1
Blaineau, C; Fagard, R; Fischer, S; Gacon, G; Genetet, N; Le Prise, Y; Piau, JP; Reibel, L	1
Ito, T; Moore, GE	1
Hersh, EM; Ohno, R	1
Holland, JF; Onuma, T; Waligunda, J	1

Other Studies

51 other study(ies) available for tyrosine and Leukemia, Myeloid, Acute

Article	Year
Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML. Cancer research, 2022, 06-06, Volume: 82, Issue:11 Topics: Allosteric Regulation; Animals; Apoptosis; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyrimidines; Tyrosine	2022
Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia. Molecular & cellular proteomics : MCP, 2023, Volume: 22, Issue:3 Topics: Animals; Apoptosis; Cell Line, Tumor; Dasatinib; DNA; DNA-Activated Protein Kinase; Leukemia, Myeloid, Acute; Mice; Mutation; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases; Serine; Signal Transduction; Threonine; TOR Serine-Threonine Kinases; Tyrosine	2023
Fluorescence spectral detection of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML): A novel photodiagnosis strategy. Photodiagnosis and photodynamic therapy, 2020, Volume: 29 Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spectrometry, Fluorescence; Tryptophan; Tyrosine	2020
FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27 Haematologica, 2017, Volume: 102, Issue:8 Topics: Cell Cycle Checkpoints; Cyclin-Dependent Kinase Inhibitor p27; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Phosphorylation; Protein Kinase Inhibitors; Tandem Repeat Sequences; Tumor Cells, Cultured; Tyrosine	2017
Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication. PloS one, 2013, Volume: 8, Issue:9 Topics: Animals; Apoptosis; Calnexin; Cell Line; Cell Proliferation; Endoplasmic Reticulum; fms-Like Tyrosine Kinase 3; Glycosylation; Heat-Shock Proteins; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-pim-1; Serine; Signal Transduction; STAT5 Transcription Factor; Tyrosine	2013
Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets. Journal of thrombosis and haemostasis : JTH, 2014, Volume: 12, Issue:5 Topics: Adenosine Triphosphate; Adult; Blood Platelet Disorders; Blood Platelets; Core Binding Factor Alpha 2 Subunit; Family Health; Female; Gene Expression Profiling; Humans; Integrin beta3; Leukemia, Myeloid, Acute; Male; NF-E2 Transcription Factor, p45 Subunit; Pedigree; Phenotype; Phosphorylation; Platelet Aggregation; Platelet Function Tests; Platelet Membrane Glycoprotein IIb; Signal Transduction; Tyrosine; Young Adult	2014
FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation. Blood, 2015, Mar-19, Volume: 125, Issue:12 Topics: Adult; Agammaglobulinaemia Tyrosine Kinase; Apoptosis; Bone Marrow Cells; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; Mass Spectrometry; Middle Aged; NF-kappa B; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; STAT5 Transcription Factor; Toll-Like Receptor 9; Tumor Suppressor Proteins; Tyrosine; Young Adult	2015
Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling. Oncotarget, 2016, Sep-06, Volume: 7, Issue:36 Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Proliferation; Chlorocebus aethiops; COS Cells; Disease Models, Animal; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Recurrence, Local; Oligonucleotide Array Sequence Analysis; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src Homology Domains; Tyrosine; Ubiquitination	2016
Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML. PloS one, 2008, Jun-18, Volume: 3, Issue:6 Topics: Animals; Base Sequence; Chlorocebus aethiops; COS Cells; DNA Primers; Endocytosis; Leukemia, Myeloid, Acute; Ligands; Mutagenesis, Site-Directed; Receptors, Granulocyte Colony-Stimulating Factor; Tyrosine	2008
Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia. The Journal of biological chemistry, 2009, Jan-23, Volume: 284, Issue:4 Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytokines; Enzyme Activation; Gene Expression Regulation, Neoplastic; Homeobox A10 Proteins; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Mutation; Myeloid Cells; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Tyrosine	2009
A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. British journal of haematology, 2009, Volume: 146, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cell Survival; Cell Transformation, Neoplastic; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Signal Transduction; STAT5 Transcription Factor; Tumor Cells, Cultured; Tyrosine	2009
Ligation of CD44 with low-molecular-weight hyaluronan and a monoclonal antibody leads to inhibition of drug-induced apoptosis in a human myeloid cell line. Hematology (Amsterdam, Netherlands), 2009, Volume: 14, Issue:4 Topics: Antibodies, Monoclonal; Apoptosis; Cell Line, Tumor; Genistein; Hematopoietic Stem Cells; Humans; Hyaluronan Receptors; Hyaluronic Acid; Leukemia, Myeloid, Acute; Ligands; Molecular Weight; Myeloid Cells; Phosphorylation; Tyrosine	2009
Can treating the SYK cell cure leukemia? Cancer cell, 2009, Oct-06, Volume: 16, Issue:4 Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Gefitinib; Gene Expression Regulation, Leukemic; Genomics; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Morpholines; Oxazines; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteomics; Pyridines; Pyrimidines; Quinazolines; Syk Kinase; Time Factors; Tyrosine	2009
Proteomic and genetic approaches identify Syk as an AML target. Cancer cell, 2009, Oct-06, Volume: 16, Issue:4 Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Differentiation; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Gefitinib; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genomics; HL-60 Cells; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Morpholines; Oxazines; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteomics; Pyridines; Pyrimidines; Quinazolines; RNA Interference; Syk Kinase; Tandem Mass Spectrometry; Time Factors; Tumor Cells, Cultured; Tyrosine; U937 Cells; Xenograft Model Antitumor Assays	2009
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia. Leukemia research, 2011, Volume: 35, Issue:10 Topics: Adult; Antibodies; Bone Marrow; CSK Tyrosine-Protein Kinase; DNA Probes; Female; Gene Expression; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; Microscopy, Fluorescence; Mitochondrial Proteins; Myeloid Progenitor Cells; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; src-Family Kinases; Tyrosine	2011
Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells. Journal of cellular physiology, 2012, Volume: 227, Issue:6 Topics: Antioxidants; Cell Line, Tumor; Electromagnetic Fields; Gene Expression Regulation, Enzymologic; Humans; Leukemia, Myeloid, Acute; Lipopolysaccharides; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Molecular; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; Reactive Nitrogen Species; Reactive Oxygen Species; RNA, Messenger; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tyrosine	2012
Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells. PloS one, 2011, Volume: 6, Issue:9 Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Stability; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Staurosporine; Thiazoles; Tyrosine; Up-Regulation	2011
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood, 2012, Oct-18, Volume: 120, Issue:16 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Flow Cytometry; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Membrane Proteins; Mice; Mice, Knockout; Mutation; Phosphorylation; RNA, Small Interfering; Signal Transduction; src Homology Domains; Tandem Repeat Sequences; Tyrosine	2012
Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities. Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22 Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Differentiation; Cell Proliferation; Disulfides; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenomics; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Immunoprecipitation; Indoles; Leukemia, Myeloid, Acute; MCF-7 Cells; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Oximes; Protein Conformation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tyrosine; U937 Cells	2012
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation. Molecular and cellular biology, 2003, Volume: 23, Issue:13 Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cytokines; Flow Cytometry; Immunophenotyping; Interleukin-3; Karyotyping; Leukemia, Myeloid, Acute; Mice; Mutation; Neoplasm Proteins; Oncogene Proteins, Fusion; Phosphorylation; Receptors, Interleukin-3; Retroviridae; Signal Transduction; Spleen; src Homology Domains; Time Factors; Tyrosine	2003
Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). The Journal of biological chemistry, 2003, Aug-29, Volume: 278, Issue:35 Topics: Animals; Benzofurans; Blotting, Western; Cell Division; Cell Line; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Genes, Dominant; Genetic Vectors; Green Fluorescent Proteins; Humans; Inhibitory Concentration 50; Interleukin-3; Leukemia, Myeloid, Acute; Luminescent Proteins; MAP Kinase Signaling System; Mice; Milk Proteins; Models, Biological; Models, Chemical; Mutation; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrazoles; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Retroviridae; Signal Transduction; STAT5 Transcription Factor; Time Factors; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine	2003
Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Blood, 2004, Mar-01, Volume: 103, Issue:5 Topics: Adult; Aged; Blotting, Western; Cohort Studies; Dose-Response Relationship, Drug; Flow Cytometry; fms-Like Tyrosine Kinase 3; Gene Duplication; Genes, p53; Genes, ras; Humans; Karyotyping; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Leukocytes, Mononuclear; Middle Aged; Mutation; Phosphorylation; Polymerase Chain Reaction; Prognosis; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Time Factors; Treatment Outcome; Tyrosine	2004
G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact. Blood, 2004, Aug-01, Volume: 104, Issue:3 Topics: Amino Acid Sequence; Animals; Binding Sites; Disease Models, Animal; DNA-Binding Proteins; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Mutant Strains; Milk Proteins; Neutropenia; Receptors, Granulocyte Colony-Stimulating Factor; Repressor Proteins; Sequence Deletion; Signal Transduction; src Homology Domains; STAT3 Transcription Factor; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors; Tyrosine	2004
Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). Blood, 2005, Jan-01, Volume: 105, Issue:1 Topics: Animals; Cell Cycle; Cell Line; DNA-Binding Proteins; Enzyme Activation; fms-Like Tyrosine Kinase 3; Gene Expression Regulation; Humans; Leukemia, Myeloid, Acute; Mice; Milk Proteins; Models, Molecular; Mutation; Phosphotyrosine; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine	2005
Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity. Blood, 2005, Feb-01, Volume: 105, Issue:3 Topics: Aminoglycosides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Binding Sites; Blast Crisis; Cell Line, Tumor; Cell Survival; Flow Cytometry; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Protein Transport; Sialic Acid Binding Ig-like Lectin 3; Tyrosine	2005
Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation. Blood, 2005, Jun-15, Volume: 105, Issue:12 Topics: Adolescent; Adult; Alleles; Amino Acid Motifs; Blood Platelet Disorders; Blood Platelets; Blotting, Western; Core Binding Factor Alpha 2 Subunit; DNA; DNA Primers; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Exons; Family Health; Female; Flow Cytometry; Frameshift Mutation; Gene Expression Regulation; Genetic Predisposition to Disease; Germ-Line Mutation; Heterozygote; Humans; Immunoblotting; Leukemia, Myeloid, Acute; Male; Middle Aged; Models, Genetic; Mutation; Pedigree; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Thrombopoietin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thrombocytopenia; Thrombopoietin; Transcription Factors; Tyrosine	2005
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. Blood, 2006, May-01, Volume: 107, Issue:9 Topics: Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Cell Line; DNA, Neoplasm; Enzyme Activation; fms-Like Tyrosine Kinase 3; Humans; In Vitro Techniques; Interleukin-3; Leukemia, Myeloid, Acute; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Protein Structure, Tertiary; Recombinant Proteins; STAT5 Transcription Factor; Staurosporine; Tyrosine	2006
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. Blood, 2006, Aug-15, Volume: 108, Issue:4 Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Myeloproliferative Disorders; Protein Structure, Tertiary; Signal Transduction; STAT5 Transcription Factor; Tyrosine	2006
Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer science, 2006, Volume: 97, Issue:9 Topics: Adamantane; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Cells, Cultured; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Humans; Hydroquinones; Imatinib Mesylate; Inhibitory Concentration 50; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Phosphorylation; Piperazines; Pyrimidines; Tyrosine	2006
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. Blood, 2007, Mar-15, Volume: 109, Issue:6 Topics: Cells, Cultured; DNA Damage; Electrophoresis, Gel, Two-Dimensional; fms-Like Tyrosine Kinase 3; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Protein Isoforms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Suppressor Protein p53; Tyrosine	2007
Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. The Journal of clinical investigation, 2008, Volume: 118, Issue:3 Topics: Animals; Apoptosis; Cell Differentiation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interferon Regulatory Factors; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Myeloproliferative Disorders; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Transcription, Genetic; Tyrosine; U937 Cells	2008
Ongoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities. The Journal of pathology, 2008, Volume: 214, Issue:5 Topics: Animals; Apoptosis; Bystander Effect; DNA Damage; DNA, Neoplasm; Immunoenzyme Techniques; Leukemia, Myeloid, Acute; Leukemia, Radiation-Induced; Macrophages; Mice; Mice, Inbred CBA; Signal Transduction; Tumor Suppressor Protein p53; Tyrosine	2008
G-CSF induces tyrosine phosphorylation of the JAK2 protein in the human myeloid G-CSF responsive and proliferative cells, but not in mature neutrophils. Biochemical and biophysical research communications, 1994, Sep-15, Volume: 203, Issue:2 Topics: Cell Division; Granulocyte Colony-Stimulating Factor; Humans; Immunosorbent Techniques; Janus Kinase 2; Kinetics; Leukemia, Myeloid, Acute; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Tumor Cells, Cultured; Tyrosine	1994
Tyrosine phosphorylation of vav protooncogene product in primary human myelogenous leukemic cells stimulated by granulocyte colony-stimulating factor. Biochemical and biophysical research communications, 1995, Jun-15, Volume: 211, Issue:2 Topics: Amino Acid Sequence; Antibodies; Blotting, Western; Cell Cycle Proteins; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine	1995
c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells. Leukemia, 1996, Volume: 10, Issue:9 Topics: Adaptor Proteins, Signal Transducing; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid, Acute; Phosphorylation; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-kit; Recombinant Proteins; src Homology Domains; Stem Cell Factor; Stimulation, Chemical; Tumor Cells, Cultured; Tyrosine; Ubiquitin-Protein Ligases	1996
[Successful treatment of acute non-lymphoblastic leukemia from myelodysplastic syndrome by combination of human macrophage colony-stimulating factor (M-CSF) and low dose cytosine arabinoside: M-CSF-induced proliferation and tyrosine phosphorylation in leu [Rinsho ketsueki] The Japanese journal of clinical hematology, 1996, Volume: 37, Issue:11 Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Blast Crisis; Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Macrophage Colony-Stimulating Factor; Myelodysplastic Syndromes; Phosphorylation; Tyrosine	1996
Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia. Blood, 1999, Jan-15, Volume: 93, Issue:2 Topics: Animals; Cytochalasin D; DNA Mutational Analysis; DNA-Binding Proteins; Granulocyte Colony-Stimulating Factor; Humans; Leucine; Leukemia, Myeloid, Acute; Mice; Milk Proteins; Mutagenesis, Site-Directed; Mutation; Neutropenia; Receptors, Granulocyte Colony-Stimulating Factor; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Structure-Activity Relationship; Trans-Activators; Tumor Cells, Cultured; Tyrosine	1999
Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. The EMBO journal, 2000, Apr-17, Volume: 19, Issue:8 Topics: 3T3 Cells; Animals; Bone Marrow; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 15; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Fibrosarcoma; Hematopoietic Stem Cells; Humans; Isoenzymes; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Mice; Milk Proteins; Muscle, Skeletal; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Proto-Oncogene Proteins c-ets; Receptor, trkC; Repressor Proteins; Signal Transduction; STAT5 Transcription Factor; Tissue Distribution; Trans-Activators; Transcription Factors; Translocation, Genetic; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine	2000
Direct effect of bispecific anti-CD33 x anti-CD64 antibody on proliferation and signaling in myeloid cells. Leukemia research, 2001, Volume: 25, Issue:12 Topics: Antibodies, Bispecific; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Division; Humans; Interferon-gamma; Leukemia, Myeloid, Acute; Monocytes; Phagocytosis; Phosphorylation; Receptors, IgG; Sialic Acid Binding Ig-like Lectin 3; Tumor Cells, Cultured; Tyrosine; Vanadates	2001
Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Leukemia, 2002, Volume: 16, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Carrier Proteins; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; Electrophoretic Mobility Shift Assay; Epithelial Cells; Etoposide; Humans; Interleukin-6; Intracellular Signaling Peptides and Proteins; Janus Kinase 1; Leukemia, Myeloid, Acute; Phosphorylation; Protein Transport; Protein-Tyrosine Kinases; Repressor Proteins; Signal Transduction; Smad3 Protein; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured; Tyrosine	2002
Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML. Leukemia, 2002, Volume: 16, Issue:4 Topics: Bone Marrow; Cell Differentiation; Hematopoiesis; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mutation; Oncogene Proteins, Fusion; Protein-Tyrosine Kinases; Signal Transduction; Transcription Factors; Tyrosine	2002
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. The Journal of biological chemistry, 1992, Sep-05, Volume: 267, Issue:25 Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Cytokines; Hematopoiesis; Hematopoietic Cell Growth Factors; Humans; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid, Acute; Oncogene Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins c-vav; Recombinant Proteins; Stem Cell Factor; Transfection; Tyrosine	1992
Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood, 1991, Dec-01, Volume: 78, Issue:11 Topics: Blotting, Northern; Blotting, Western; Cell Division; Gene Expression; Hematopoietic Cell Growth Factors; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine	1991
Regulation of protein phosphotyrosine content by changes in tyrosine kinase and protein phosphotyrosine phosphatase activities during induced granulocytic and monocytic differentiation of HL-60 leukemia cells. Biochemical and biophysical research communications, 1986, Oct-15, Volume: 140, Issue:1 Topics: Cell Differentiation; Cell Line; Granulocytes; Humans; Leukemia, Myeloid, Acute; Monocytes; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine	1986
Biochemical characterization of tyrosine kinase and phosphotyrosine phosphatase activities of HL-60 leukemia cells. Cancer research, 1988, Aug-01, Volume: 48, Issue:15 Topics: Adenosine Triphosphate; Cations, Divalent; Cell Line; Ethylmaleimide; Guanosine Triphosphate; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; Peptides; Phosphoprotein Phosphatases; Phosphotyrosine; Polymers; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine	1988
Alterations in tyrosine phosphorylation during the granulocytic maturation of HL-60 leukemia cells. Cancer research, 1988, Jan-01, Volume: 48, Issue:1 Topics: Aclarubicin; Anthracyclines; Antibiotics, Antineoplastic; Cell Differentiation; Dimethyl Sulfoxide; Humans; Leukemia, Myeloid, Acute; Naphthacenes; Phosphoprotein Phosphatases; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Thioguanine; Tumor Cells, Cultured; Tyrosine	1988
Abnormal serum phenylalanine-tyrosine ratio and hyperferritinemia in malignant histiocytosis. Pediatric hematology and oncology, 1988, Volume: 5, Issue:4 Topics: Adolescent; Child; Child, Preschool; Female; Ferritins; Histiocytic Sarcoma; Humans; Infant; L-Lactate Dehydrogenase; Leukemia, Myeloid, Acute; Male; Measles; Phenylalanine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines; Tyrosine	1988
Acute myeloblastic leukemia with active tyrosine protein kinase. Leukemia research, 1985, Volume: 9, Issue:11 Topics: Gastrins; Humans; Leukemia, Myeloid, Acute; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine	1985
The growth-stimulating activity of peptides on human hematopoietic cell cultures. Experimental cell research, 1969, Volume: 56, Issue:1 Topics: Alanine; Amino Acids; Cell Division; Cell Line; Culture Media; Culture Techniques; Dipeptides; Growth Substances; Hematopoiesis; Humans; Kinetics; Leukemia, Myeloid, Acute; Lymphocyte Activation; Lymphocytes; Peptides; Phenylalanine; Tryptophan; Tyrosine; Valine	1969
Immunosuppressive effects of L-asparaginase. Cancer research, 1970, Volume: 30, Issue:6 Topics: Adrenal Gland Neoplasms; Adult; Aged; Alanine; Antibody Formation; Antigens; Asparaginase; Asparagine; Breast Neoplasms; Carcinoma; Child, Preschool; Female; Glutamates; Hemocyanins; Humans; Hypersensitivity, Delayed; Immunoglobulins; Immunosuppressive Agents; Lectins; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Lysine; Male; Middle Aged; Neoplasms; Osteosarcoma; Tyrosine	1970
Amino acid requirements in vitro of human leukemic cells. Cancer research, 1971, Volume: 31, Issue:11 Topics: Amino Acids; Asparaginase; Asparagine; Cells, Cultured; Culture Media; Cysteine; Female; Glutamine; Histidine; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Tritium; Tyrosine; Uridine	1971