tyrosine has been researched along with Invasiveness, Neoplasm in 145 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (13.79) | 18.2507 |
| 2000's | 73 (50.34) | 29.6817 |
| 2010's | 47 (32.41) | 24.3611 |
| 2020's | 5 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Yuki, R | 1 |
| Endo, M; Ikeda, K; Minami, Y; Nishita, M; Okada, Y; Saji, T | 1 |
| Fu, P; Jiang, N; Sang, M; Sun, X; Wang, X; Xie, L; Xu, H; Xu, Q; Zeng, L; Zhao, Q | 1 |
| Bello-Alvarez, C; Camacho-Arroyo, I; González-Arenas, A; Moral-Morales, AD | 1 |
| Ji, J; Ji, Y; Tang, Z; Tian, Y; Yang, C; Yang, Y; Yao, H; Zhang, Z; Zheng, X; Zhu, X | 1 |
| Cao, X; Cong, YS; Dai, X; Feng, XH; Guo, X; Ji, X; Li, L; Liang, T; Si, Y; Tang, M; Xia, Z; Xu, L; Yan, H; Ye, S; Zhang, H; Zhao, B; Zhao, H; Zhou, Q; Zhu, C | 1 |
| Lauffenburger, D; Shao, H; Wang, A; Wells, A | 1 |
| Fujinaga, T; Hayashi, Y; Hiyama, S; Honma, K; Iijima, H; Maekawa, A; Mizushima, T; Morii, E; Nagai, K; Sakatani, A; Shinzaki, S; Takehara, T; Tsujii, M; Tsujii, Y; Watabe, K; Yoshii, S | 1 |
| Dong, J; Jiang, L; Liang, Y; Liu, P; Wang, H; Wang, S | 1 |
| Han, J; Huang, Y; Jin, H; Liu, P; Liu, X; Meng, X; Tan, X; Wu, Y; Yu, B | 1 |
| Faridi, W; Gondal, FR; Husnain, M; Kohli, M; Malik, SU; Riaz, IB; Sipra, QUAR; Xie, H; Yadav, S | 1 |
| Bode, AM; Cao, Y; Deng, X; Dong, Z; Li, L; Tang, M; Tao, Y; Xiao, L; Xu, J; Yang, L; Zhong, J | 1 |
| Barbosa, MA; Cardoso, AP; Figueiredo, C; Gonçalves, R; Mantovani, A; Mareel, M; Oliveira, MI; Oliveira, MJ; Pinto, AT; Pinto, ML; Pinto, MT; Relvas, JB; Seruca, R | 1 |
| Agarwal, R; Bhat, TA; Nambiar, D; Pal, A; Singh, RP; Tailor, D | 1 |
| Cao, X; Fan, L; Huang, F; Jiang, Y; Li, H; Li, J; Pan, H; Sun, J; Wang, Q; Wang, X | 1 |
| Cheng, Y; Fujimura, A; Ichikawa, T; Matsui, H; Michiue, H; Nishiki, T; Tani, Y; Tomizawa, K; Uneda, A; Wei, FY | 1 |
| Hu, Z; Liu, Y; Qiu, J; Xiong, Z; Zheng, J; Zhu, Z | 1 |
| Guo, B; Li, X; Su, J; Wang, K; Zhang, T | 1 |
| Kos, J; Pečar Fonović, U | 1 |
| Acoba, J; Furuya, H; Paladino, D; Rosser, CJ; Turkson, J; Yue, P | 1 |
| Chen, PT; Chiu, YW; Hsu, YK; Huang, CM; Liou, LY; Luo, FJ; Yuan, TC | 1 |
| Jiang, WG; Kynaston, HG; Sanders, AJ; Weeks, HP | 1 |
| Cárdenas, A; Contreras, P; Cooper-White, J; Díaz, J; Díaz, MI; Díaz, N; Leyton, L; Lobos-Gonzalez, L; Ortiz, R; Otte, E; Quest, AF; Torres, V | 1 |
| Gnirck, AC; Larsson, O; Lin, Y; Sehat, B; Warsito, D | 1 |
| Fujii, H; Kusama, T; Okamoto, H | 1 |
| Li, FX; Shao, WF; Tang, R; Wen, QS; Xiong, JB; Yu, XR; Yu, YL | 1 |
| Cao, R; Dan, HC; Jiang, W; Ju, L; Qian, G; Wang, G; Wang, X; Wang, Y; Wu, M; Xiao, Y | 1 |
| Cao, L; Freeman, JW; Jin, C; Lazor, JW; Sperry, J; Venkatasubbarao, K; Zhao, S | 1 |
| Beaulieu, E; Béliveau, R; Fontaine, N; Gingras, D; Michaud, M; Nyalendo, C; Sartelet, H | 1 |
| Albitar, L; Aponte, M; Cramer, DW; Edwards, D; Jiang, W; Lakkis, M; Li, MJ; Mok, SC; Vitonis, A; Ye, B | 1 |
| Buck, AK; Eckel, F; Friess, H; Herrmann, K; Kleeff, J; Krause, BJ; Scheidhauer, K; Schmid, RM; Schmidt, S; Schuster, T; Schwaiger, M; Wester, HJ | 1 |
| Kodama, R; Nakahara, M; Nakamura, Y; Sanke, T; Tsujimoto, M; Yasuoka, H; Yoshidome, K | 1 |
| Hijiya, N; Kawahara, K; Miyawaki, M; Moriyama, M; Nakada, C; Tsukamoto, Y | 1 |
| Bagnato, A; Biroccio, A; Cianfrocca, R; Di Castro, V; Masi, S; Natali, PG; Nicotra, MR; Rosanò, L; Salvati, E; Spinella, F | 1 |
| Connolly, Y; Gorgoulis, VG; Liontos, M; Malliri, A; Rooney, C; Whetton, AD; Woodcock, SA; Zoumpourlis, V | 1 |
| Chang, CF; Koay, ES; Wong, LL; Zhang, D | 1 |
| Chan, KT; Cortesio, CL; Huttenlocher, A | 1 |
| Elliott, BE; Foley, JH; Jia, Z; Li, JJ; Miller, F; Singh, VK; Wright, TG | 1 |
| Buchfelder, M; Doelken, M; Ganslandt, O; Kuwert, T; Linke, R; Nimsky, C; Pölking, E; Prante, O; Stadlbauer, A | 1 |
| Akimoto, S; Hirohashi, S; Ino, Y; Ito, H; Ochiai, A; Shomori, K; Shudo, K | 1 |
| Arias, M; Bravo-Cordero, JJ; Chen, X; Condeelis, J; Desmarais, V; Koleske, AJ; Mader, CC; Oser, M; van Rheenen, J; Yamaguchi, H | 1 |
| Geng, M; Li, J; Peng, Y | 1 |
| Guo, L; Li, A; Si, J; Zhou, T | 1 |
| Antonyak, M; Baird, D; Cerione, RA; Feng, Q; Yoo, S | 1 |
| Fujii, S; Hiraoka, N; Kanai, Y; Kosuge, T; Miyazawa, Y; Nojima, Y; Sakai, R; Uekita, T | 1 |
| Benveniste, EN; Lai, YJ; Lin, FT; Lin, VT; Zheng, Y | 1 |
| Balzer, EM; Cho, EH; Ioffe, OB; Martin, SS; Matrone, MA; Tuttle, KC; Vitolo, MI; Whipple, RA; Yang, J; Yoon, JR | 1 |
| Arvanitis, C; Bechill, J; Corey, SJ; Frost, JA; Hartig, SM; Jensen, SA; Marzouk, S; Pichot, CS; Yu, J | 1 |
| Bravo-Cordero, JJ; Condeelis, J; Gil-Henn, H; Koleske, AJ; Mader, CC; Magalhaes, M; Oser, M | 1 |
| Ingham, RJ; Lai, R; Li, L; McMullen, T; Wang, P; Wu, F; Young, LC; Zhang, J | 1 |
| Bajaj, E; Besmer, D; Gendler, SJ; Hwang, SI; Lee, YY; Mukherjee, P; Nath, S; Roy, LD; Sahraei, M; Shanmugam, K; Subramani, DB; Tinder, TL | 1 |
| Anders, RA; Edil, BH; Foley, K; Huang, L; Illei, PB; Jaffee, EM; Laheru, D; Le, DT; Leubner, A; Maitra, A; Mizuma, M; Mo, G; Olino, K; Sharma, R; Van Eyk, JE; Zheng, L | 1 |
| Hussaini, IM; Lopes, MB; Merk, BC; Owens, JL; Silva, CM | 1 |
| Backer, JM; Boimel, PJ; Bresnick, AR; Condeelis, JS; Coniglio, SJ; Flinn, RJ; Hynes, NE; Pozzuto, M; Segall, JE; Smirnova, T; Wyckoff, J; Zhou, ZN | 1 |
| Aasheim, HC; Iversen, N; Sandset, PM; Skretting, G; Sletten, M; Stavik, B; Tinholt, M; Zernichow, L | 1 |
| Brábek, J; Brůhová, Z; Hanks, SK; Janoštiak, R; Novotný, M; Rösel, D; Tolde, O | 1 |
| Dusseault, J; Ismaïl, S; Labelle-Côté, M; Larose, L; Picard-Cloutier, A; Siegel, PM | 1 |
| Jeziorski, A; Kedzierska, M; Olas, B; Piekarski, J; Wachowicz, B | 1 |
| Arpin, M; Day, A; Elliott, BE; Mak, H; Naba, A; Schick, C; SenGupta, SK; Varma, S | 1 |
| Cho, NL; Du, J; Ito, H; Lin, CI; Moore, FD; Ruan, DT; Whang, EE | 1 |
| Bruzzo, J; Chiarella, P; Meiss, RP; Ruggiero, RA | 1 |
| Caron, C; Chabot, C; Elchebly, M; Gavard, J; Hebda, JK; Langlois, S; Lapointe, L; Royal, I; Spring, K; Trinh, NT | 1 |
| Allbritton, N; Lawrence, DS; Xu, W | 1 |
| Chiou, SH; Hung, MC; Hung, SC; Lee, YT; Lin, SP; Miller, SA; Wang, JY | 1 |
| Choi, YJ; Jung, O; Kang, M; Kim, HJ; Kwak, TK; Lee, JW; Lee, MS; Ryu, J | 1 |
| Allen, JK; Armaiz-Pena, GN; Bar-Eli, M; Cole, SW; Cruz, A; De Geest, K; Deavers, MT; English, RD; Gallick, GE; Gharpure, KM; Han, LY; Jackson, DB; Lin, YG; Lopez, GE; Lopez-Berestein, G; Lutgendorf, SK; Mangala, LS; Nagaraja, AS; Nick, AM; Rodriguez-Aguayo, C; Shahzad, MM; Shazhad, MM; Soldatos, TG; Soman, KV; Sood, AK; Stone, RL; Torres-Lugo, M; Villares, GJ; Vivas-Mejia, P; Wiktorowicz, JE; Wu, Z; Young, T; Zien, A; Zigler, M | 1 |
| Cattaneo, MG; Francolini, M; Massari, S; Perego, C; Pietrini, G; Pola, S; Raimondi, A; Vanoni, C; Vicentini, LM | 1 |
| Kanayama, N; Kobayashi, H; Nishida, T; Suzuki, M; Takigawa, M; Terao, T | 1 |
| Imamura, F; Inoue, M; Iwasaki, T; Kobayashi, S; Mukai, M; Murakami-Murofushi, K; Nakamura, H; Tatsuta, M; Togawa, A | 1 |
| Aingorn, H; Cohen, I; Cohen, M; Geiger, B; Goldshmidt, O; Katz, BZ; Nadav, L; Vlodavsky, I; Zcharia, E | 1 |
| Fu, X; Fu, YM; Ge, X; Li, YQ; Meadows, GG; Sanchez, PJ; Yu, ZX | 1 |
| Davies, G; Jiang, WG; Lane, J; Mansel, RE; Martin, TA; Matsumoto, K; Nakamura, T; Parr, C; Watkins, G | 1 |
| Davies, G; Jiang, WG; Lane, J; Martin, TA; Mason, MD; Matsumoto, K; Nakamura, T; Parr, C; Watkins, G | 1 |
| Boerner, JL; Danielsen, AJ; Darce, JR; Faupel-Badger, JM; Juneja, SC; Lovejoy, CA; Maihle, NJ; Wang, Z | 1 |
| Das, R; Kundu, GC; Mahabeleshwar, GH | 1 |
| Band, H; Fernandis, AZ; Ganju, RK; Klösel, R; Prasad, A | 1 |
| Kwon, HJ; Lee, HS; Shim, JS; Shin, J | 1 |
| Allen, J; Costello, G; Curwen, J; Fennell, M; Green, TP; Hennequin, LF; Lambert-Van Der Brempt, C; Plé, PA | 1 |
| Basolo, F; Castellone, MD; Celetti, A; Cirafici, AM; Curcio, F; Fusco, A; Giannini, R; Guarino, V; Kruhoffer, M; Medico, E; Melillo, RM; Orntoft, TF; Santoro, M | 1 |
| Pai, R; Tarnawski, AS; Tran, T | 1 |
| Huang, CJ; Huang, YT; Hwang, JJ; Kandaswami, C; Ke, FC; Lee, AY; Lee, LT; Lee, MT; Lee, PP | 1 |
| Comoglio, PM; Conrotto, P; Corso, S; Gamberini, S; Giordano, S | 1 |
| Chen, B; Larsen, SH; Li, CY; Sun, HB; Wang, SY; Xu, WX; Yang, RF; Yang, X; Yue, PB; Zhan, YQ; Zheng, H | 1 |
| Carpenter, WM; Huang, L; Kramer, RH; Lin, CS; Murai, M; Regezi, J; Shen, X; Silverman, S | 1 |
| De Bruyne, G; Lauwaet, T; Leroy, A; Mareel, M; Oliveira, MJ | 1 |
| Alaimo, G; Alessandro, R; Corrado, C; De Leo, A; De Leo, G; Flugy, AM; Russo, D; Stassi, G | 1 |
| Ullrich, A; van der Horst, EH; Weber, I | 1 |
| Bamberger, AM; Brümmer, J; Ebrahimnejad, A; Horst, AK; Nollau, P; Streichert, T; Wagener, C | 1 |
| Baldi, E; Bonaccorsi, L; Carloni, V; Forti, G; Marchiani, S; Muratori, M | 1 |
| Adithi, M; Krishnakumar, S; Nalini, V | 1 |
| Cornillon, J; Denoyer, D; Dubois, F; Le Jeune, N; Perek, N | 1 |
| Acs, G; Cohen, N; Dalgard, C; Lai, SY; Lu, H; Mohyeldin, A; Verma, A | 1 |
| Brábek, J; Constancio, SS; Hanks, SK; Pozzi, A; Shin, NY; Siesser, PF | 1 |
| Furukawa, K; Hamamura, K; Hattori, H; Hattori, T; Hayashi, T; Lloyd, KO; Mizutani, H; Nakano, J; Nakashima, H; Okuda, T; Ueda, M; Urano, T | 1 |
| Gan, B; Guan, JL; Wu, X; Yoo, Y | 1 |
| Berod, L; Corvinus, FM; Fitzgerald, JS; Friedrich, K; Markert, UR; Meissner, A; Pfitzner, E; Poehlmann, TG; Tsareva, SA; Wiederanders, B | 1 |
| Chang, LC; Chen, BH; Chen, HC; Cheng, CH; Huang, CH | 1 |
| Bruckner-Tuderman, L; Heino, J; Kainulainen, T; Nissinen, L; Parikka, M; Salo, T; Tasanen, K | 1 |
| Chen, KH; Huang, SH; Lin, CJ; Lin, CY; Wang, SM; Wu, JC | 1 |
| Chen, HC; Chen, SY | 1 |
| Cedazo-Minguez, A; Chuan, YC; Flores-Morales, A; Norstedt, G; Pang, ST; Pousette, A | 1 |
| Chen, CT; Lou, PJ; Wang, CP; Yang, TH | 1 |
| Aixinjueluo, W; Furukawa, K; Hamamura, K | 1 |
| Bigner, DD; Friedman, HS; Hjelmeland, AB; Jackson, D; Keir, ST; Ohmori, O; Rich, JN; Shi, Q; Song, L; Wickman, S | 1 |
| Brulé-Donneger, S; Chaigneau, T; Charnaux, N; Friand, V; Gattegno, L; Kraemer, M; Nahon, P; Poiré, A; Saffar, L; Sainte-Catherine, O; Salzmann, JL; Sutton, A; Vassy, J; Ziol, M | 1 |
| Brunton, VG; Frame, MC; Harrington, K; Hooper, S; Macpherson, IR; McGarry, L; Ozanne, BW; Sahai, E; Serrels, A | 1 |
| Cerny, RL; Gendler, SJ; Hollingsworth, MA; Kazlauskas, A; Shanmugam, K; Singh, PK; Swanson, BJ; Wen, Y | 1 |
| Cao, J; Luo, HS; Song, WC; Yu, HG; Yu, JP; Zhou, L | 1 |
| Goetz, JG; Joshi, B; Kojic, LD; Lajoie, P; Nabi, IR; Scudamore, T; Strugnell, SS | 1 |
| Brantley-Sieders, DM; Chen, J; Fang, WB; Ham, AJ; Hwang, Y | 1 |
| Kramer, RH; Matsumoto, K; Nakamura, T | 1 |
| Doki, Y; Inoue, M; Iwazawa, T; Kadowaki, T; Matsui, S; Oka, H; Shimaya, K; Shiozaki, H; Takeichi, M; Tamura, S | 1 |
| Boghaert, ER; Chan, SK; Galardy, RE; Grobelny, D; Vanaman, TC; Zimmer, C; Zimmer, SG | 1 |
| Hayakawa, M; Hori, T; Ito, F; Kitamura, N; Miyazawa, K; Oku, N; Shibamoto, S; Takeichi, M; Takeuchi, K | 1 |
| Cardeiro, DJ; Elstad, CA; Huijzer, JC; Meadows, GG; Uhlenkott, CE | 1 |
| Akedo, H; Imamura, F; Isoai, A; Kitagawa, I; Kobayashi, M; Mukai, M; Shinkai, K | 1 |
| Chaitchik, S; Feldman, I; Fishman, P; Merimsky, O; Rapaport, Y; Shafir, R; Sheonfeld, Y | 1 |
| Akimoto, S; Gotoh, M; Hirohashi, S; Kanai, Y; Machinami, R; Ochiai, A; Shibata, T; Yasui, N | 1 |
| Bremer, EG; Kaneko, Y; Moskal, JR; Rebbaa, A; Yamamoto, H | 1 |
| Akiyoshi, T; Mafune, K; Mori, M; Sugimachi, K; Tanaka, S; Tanaka, Y; Wands, JR | 1 |
| Han, R; Yan, C | 2 |
| Ambesi-Impiombato, FS; Besati, C; Cecchini, G; De Filippi, R; Marchisio, PC; Serini, G; Trusolino, L | 1 |
| Birembault, P; Nawrocki, B; Polette, M; Tournier, JM; Van Hengel, J; Van Roy, F | 1 |
| Daniels, KJ; Hay, ED; Kim, K | 1 |
| Date, K; Kuba, K; Matsumoto, K; Nakamura, T; Shimura, H; Tanaka, M | 1 |
| Arena, N; de Luca, A; Medico, E; Sena, LM | 1 |
| Avraham, H; Avraham, S; Fu, Y; Keydar, I; Schinkmann, K; Settleman, J; Shaw, L; Zrihan-Licht, S | 1 |
| Akedo, H; Ayaki, M; Imamura, F; Mukai, M | 1 |
| Fu, YM; Meadows, GG; Pelayo, BA | 2 |
| Bertagnolli, MM; Carothers, AM; Dannenberg, AJ; Weyant, MJ | 1 |
| Bruyneel, EA; Delannoy, P; Goeman, JL; Hilkens, J; Huet, G; Krzewinski-Recchi, MA; Mareel, MM; Oomen, LC; Philippé, J; Steelant, WF; Van der Eycken, J | 1 |
| Dankort, DL; Khoury, H; Muller, WJ; Naujokas, MA; Park, M; Sadekova, S | 1 |
| Chrétien, M; Khatib, AM; Luis, J; Metrakos, P; Prat, A; Seidah, NG; Siegfried, G | 1 |
| Shaw, LM | 1 |
| Brodt, P; Fallavollita, L; Khatib, AM; Samani, AA; Zhang, D | 1 |
| Davies, G; Jiang, WG; Mason, MD; Matsumoto, K; Nakamura, T; Parr, C | 1 |
| Chen, Z; Fadiel, A; Feng, Y; Naftolin, F; Ohtani, K; Rutherford, T | 1 |
| Akedo, H; Iwasaki, T; Kakishita, E; Mukai, M; Nakata, A; Sabe, H; Schaefer, E; Shinkai, K; Tatsuta, M; Terada, N; Tsujimura, T; Yano, H | 1 |
| Dubois, R; Hayashi, N; Hori, M; Ito, T; Kakiuchi, Y; Kawai, N; Kawano, S; Kimura, A; Komori, M; Sasaki, Y; Tsuji, S; Tsujii, M; Yasumaru, M | 1 |
| Avraham, H; Avraham, S; Fu, Y; McShan, GD; Park, SY; Zagozdzon, R; Zrihan-Licht, S | 1 |
| Ebihara, Y; Gong, Y; Hirano, T; Ikeda, N; Kato, H; Kato, Y; Ohira, T; Shou, Y; Yoshida, K | 1 |
| Chen, WT; Mueller, SC; Yeh, Y | 1 |
| Fridman, R; Hamilton, TC; Kanemoto, T; Martin, GR | 1 |
4 review(s) available for tyrosine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
[Aberrant Activation Mechanism of TGF-β Signaling in Epithelial-mesenchymal Transition].
Topics: Animals; Cell Movement; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; ErbB Receptors; Humans; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-abl; Signal Transduction; Smad Proteins; Transcription Factors; Transforming Growth Factor beta; Tyrosine | 2021 |
Adjuvant Therapy in High-Risk Renal Cell Cancer: A Systematic Review and Meta-analysis.
Topics: Aged; Aged, 80 and over; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nephrectomy; Prognosis; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Treatment Outcome; Tyrosine; Vascular Endothelial Growth Factor A | 2019 |
Concomitant tumor resistance.
Topics: Animals; Cell Proliferation; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Tumor Burden; Tyrosine | 2012 |
Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy.
Topics: Anoikis; Antibodies, Monoclonal; Carcinoma, Small Cell; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Glycosphingolipids; Humans; Lung Neoplasms; Melanoma; Neoplasm Invasiveness; Paxillin; Phosphorylation; Tyrosine | 2006 |
141 other study(ies) available for tyrosine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
c-Src-mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells.
Topics: Cell Line, Tumor; Genes, src; Humans; Kinesins; Microtubules; Neoplasm Invasiveness; Phosphorylation; Podosomes; Protein Tyrosine Phosphatases, Non-Receptor; Tyrosine | 2022 |
Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3
Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Female; HeLa Cells; Humans; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Phosphorylation; Resveratrol; STAT3 Transcription Factor; Tumor Burden; Tyrosine; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2020 |
Intracellular Progesterone Receptor and cSrc Protein Working Together to Regulate the Activity of Proteins Involved in Migration and Invasion of Human Glioblastoma Cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; CSK Tyrosine-Protein Kinase; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Glioblastoma; Humans; Neoplasm Invasiveness; Paxillin; Phosphorylation; Progesterone; Protein-Tyrosine Kinases; Receptors, Progesterone; RNA, Small Interfering; Signal Transduction; Tyrosine | 2021 |
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; Colorectal Neoplasms; DNA-Binding Proteins; Doxycycline; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells; Nuclear Proteins; Phenotype; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Small Interfering; Tyrosine; Xenograft Model Antitumor Assays | 2017 |
Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Adhesion; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Cells, Cultured; Female; HEK293 Cells; Hippo Signaling Pathway; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Staging; Phosphoproteins; Phosphorylation; Prognosis; Protein Serine-Threonine Kinases; Signal Transduction; src-Family Kinases; Transcription Factors; Tyrosine; Xenograft Model Antitumor Assays; YAP-Signaling Proteins | 2017 |
Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain.
Topics: Actinin; Amino Acid Substitution; Calpain; Cell Line; Cell Line, Tumor; Cell Movement; Enzyme Activation; Focal Adhesion Kinase 1; Gene Knockdown Techniques; Green Fluorescent Proteins; Humans; Melanoma; Mutation; Neoplasm Invasiveness; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Stability; Proteolysis; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA Interference; Signal Transduction; Tyrosine | 2018 |
Adenoma of colorectal laterally spreading tumor nongranular type with biological phenotypic features similar to cancer.
Topics: Adenoma; Carcinogenesis; Cohort Studies; Colorectal Neoplasms; Fibrosis; Humans; Intestinal Mucosa; Ki-67 Antigen; Microvessels; Mucins; Neoplasm Invasiveness; Nitric Oxide Synthase Type II; Phenotype; Retrospective Studies; Tumor Suppressor Protein p53; Tyrosine | 2018 |
CX3CL1/fractalkine enhances prostate cancer spinal metastasis by activating the Src/FAK pathway.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Carcinoma; Chemokine CX3CL1; CX3C Chemokine Receptor 1; ErbB Receptors; Female; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Signal Transduction; Spinal Neoplasms; src-Family Kinases; Tyrosine; Xenograft Model Antitumor Assays | 2018 |
Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway.
Topics: Carcinogenesis; Cell Movement; Humans; Integrin beta4; MAP Kinase Signaling System; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Tyrosine | 2020 |
Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma.
Topics: Binding Sites; Carcinoma; Cell Line, Tumor; Chemotaxis; Flow Cytometry; Gene Deletion; Genes, Reporter; Herpesvirus 4, Human; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Receptors, CXCR4; RNA, Small Interfering; Sulfotransferases; Tyrosine; Viral Matrix Proteins | 2013 |
Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity.
Topics: Blotting, Western; Caco-2 Cells; Cell Line, Tumor; Cell Movement; Cells, Cultured; Coculture Techniques; Colorectal Neoplasms; ErbB Receptors; Humans; Macrophages; Matrix Metalloproteinases; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Stomach Neoplasms; Time-Lapse Imaging; Tyrosine | 2014 |
Acacetin inhibits in vitro and in vivo angiogenesis and downregulates Stat signaling and VEGF expression.
Topics: Animals; Antineoplastic Agents; Capillaries; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Collagen; Drug Combinations; Endothelial Cells; Flavones; Human Umbilical Vein Endothelial Cells; Humans; Laminin; Male; Mice; Microscopy, Fluorescence; Neoplasm Invasiveness; Neovascularization, Pathologic; Nitric Oxide Synthase Type III; Phosphorylation; Proteoglycans; Rats; Rats, Wistar; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phosphatidylethanolamine Binding Protein; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; src-Family Kinases; Tissue Array Analysis; Tyrosine | 2014 |
Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.
Topics: Cell Line, Tumor; Cell Movement; Cyclin G2; Cytoskeleton; Glioblastoma; Humans; Hypoxia; Microfilament Proteins; Neoplasm Invasiveness; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Tyrosine | 2013 |
Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells.
Topics: beta Catenin; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histones; Humans; Lysine; Methylation; Neoplasm Invasiveness; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 2; RNA Interference; Signal Transduction; Stomach Neoplasms; Time Factors; Transcription, Genetic; Transfection; Tyrosine | 2014 |
Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; G1 Phase; Humans; Membrane Potential, Mitochondrial; Neoplasm Invasiveness; Phosphorylation; Quinolizines; Signal Transduction; Stomach Neoplasms; Tyrosine | 2015 |
Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis.
Topics: Cathepsin Z; Cell Line, Tumor; Clathrin; Endocytosis; Gene Expression; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Polymerization; Profilins; Proteolysis; Tyrosine | 2015 |
A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Movement; Cell Nucleus; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; E1A-Associated p300 Protein; Embryo, Mammalian; Fibroblasts; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Immunoprecipitation; Mice; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine; Wound Healing | 2016 |
Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cortactin; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mouth Neoplasms; Neoplasm Invasiveness; Phosphorylation; Precancerous Conditions; rac1 GTP-Binding Protein; Tyrosine | 2016 |
The Association Between WAVE1 and -3 and the ARP2/3 Complex in PC 3 Cells.
Topics: Actin Cytoskeleton; Actin-Related Protein 2-3 Complex; Actins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Knockdown Techniques; Humans; Indoles; Male; Neoplasm Invasiveness; Phenotype; Phosphorylation; Polymerization; Prostatic Neoplasms; Protein Binding; RNA Interference; Signal Transduction; Thiophenes; Tyrosine; Wiskott-Aldrich Syndrome Protein Family | 2016 |
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis.
Topics: Animals; Carcinogenesis; Caveolin 1; Cell Adhesion; Cell Movement; Female; Fibroblasts; Fibronectins; Humans; Integrin beta1; Laminin; Lung Neoplasms; Male; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Skin Neoplasms; Tyrosine | 2016 |
Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleus; Chromatin; Chromatin Assembly and Disassembly; DNA Helicases; DNA, Complementary; HeLa Cells; Histones; Humans; Ligands; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Proteins; Phosphorylation; Protein Binding; Receptor, IGF Type 1; Receptors, Somatomedin; Snail Family Transcription Factors; Transcription Factors; Tyrosine | 2016 |
Tyrosine Phosphorylation of Focal Adhesion Anchoring Proteins Enhances Human Pancreatic Cancer Cell Invasion.
Topics: Animals; Blotting, Western; Cattle; Cell Line; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Endothelial Cells; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Pulmonary Artery; Rifabutin; Tyrosine | 2016 |
[Phosphorylation of ezrin Tyr477 is critical in invasion of breast cancer cells stimulated by precursor of nerve growth factor].
Topics: Breast Neoplasms; Cell Line, Tumor; Cytoskeletal Proteins; Humans; MCF-7 Cells; Neoplasm Invasiveness; Nerve Growth Factor; Phosphorylation; Signal Transduction; Transfection; Tyrosine | 2016 |
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway.
Topics: Anilides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Enzyme Activation; Epithelial-Mesenchymal Transition; ErbB Receptors; G1 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3 beta; Humans; Neoplasm Invasiveness; Oxazoles; PPAR gamma; Proto-Oncogene Proteins c-akt; Simvastatin; Tyrosine; Urinary Bladder; Urinary Bladder Neoplasms | 2016 |
Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.
Topics: Blotting, Western; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphorylation; Smad4 Protein; STAT3 Transcription Factor; Transforming Growth Factor beta; Tyrosine | 2008 |
Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice.
Topics: Aneuploidy; Animals; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Fibrosarcoma; Humans; Matrix Metalloproteinase 1; Mice; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Rats; Tyrosine | 2008 |
Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer.
Topics: Cell Line, Tumor; Disease Progression; ErbB Receptors; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Models, Biological; Neoplasm Invasiveness; Ovarian Neoplasms; Paxillin; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; src-Family Kinases; Tyrosine | 2008 |
In vivo characterization of proliferation for discriminating cancer from pancreatic pseudotumors.
Topics: Adult; Aged; Diagnosis, Differential; Female; Granuloma, Plasma Cell; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Neoplasm Invasiveness; Pancreatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2008 |
Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis.
Topics: Adult; Aged; Aged, 80 and over; Alkenes; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Invasiveness; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prognosis; Receptors, CXCR4; Tyrosine | 2008 |
Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas.
Topics: Aged; Aged, 80 and over; Carcinoma; ErbB Receptors; Esophageal Neoplasms; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Phosphorylation; Tyrosine | 2008 |
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.
Topics: Arrestins; beta Catenin; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Blotting, Western; Cell Line, Tumor; ErbB Receptors; Female; Humans; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Phosphorylation; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Transplantation, Heterologous; Tyrosine | 2009 |
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.
Topics: Adherens Junctions; Animals; Calpain; Cell Line; Cell Movement; Cloning, Molecular; Dogs; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Humans; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Mutation; Neoplasm Invasiveness; Neoplasms; Oncogene Protein pp60(v-src); Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; SOS1 Protein; src Homology Domains; src-Family Kinases; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Time Factors; Transfection; Tyrosine | 2009 |
Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast cancer progression.
Topics: Biomarkers, Tumor; Breast Neoplasms; Disease Progression; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neuregulin-1; Phosphorylation; Prognosis; Protein Phosphatase 2; Protein-Tyrosine Kinases; Receptor, ErbB-2; Signal Transduction; Tissue Array Analysis; Tumor Cells, Cultured; Tyrosine | 2009 |
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Neoplasm Invasiveness; Paxillin; Recombinant Fusion Proteins; RNA, Small Interfering; src-Family Kinases; Tyrosine | 2009 |
Increased production and secretion of HGF alpha-chain and an antagonistic HGF fragment in a human breast cancer progression model.
Topics: Blotting, Western; Breast Neoplasms; Cell Transformation, Neoplastic; Culture Media, Conditioned; Disease Progression; Genes, ras; Hepatocyte Growth Factor; Humans; Mesoderm; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-met; Tyrosine | 2009 |
Detection of tumour invasion into the pyramidal tract in glioma patients with sensorimotor deficits by correlation of (18)F-fluoroethyl-L: -tyrosine PET and magnetic resonance diffusion tensor imaging.
Topics: Adult; Aged; Brain; Brain Neoplasms; Contrast Media; Diffusion Magnetic Resonance Imaging; Female; Glioma; Humans; Male; Middle Aged; Movement Disorders; Neoplasm Invasiveness; Positron-Emission Tomography; Predictive Value of Tests; Pyramidal Tracts; Radiography; Sensation Disorders; Sensitivity and Specificity; Tyrosine | 2009 |
Tyrosine-phosphorylation of the 12th armadillo-repeat of beta-catenin is associated with cadherin dysfunction in human cancer.
Topics: Antibodies, Monoclonal; beta Catenin; Blotting, Western; Cadherins; Cell Adhesion; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Immunoprecipitation; Neoplasm Invasiveness; Phosphorylation; Polymerase Chain Reaction; Receptor, ErbB-2; Stomach Neoplasms; Transforming Growth Factor alpha; Tyrosine | 2009 |
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.
Topics: Actin Depolymerizing Factors; Actin-Related Protein 2-3 Complex; Actins; Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Cortactin; Epidermal Growth Factor; Extracellular Matrix; Humans; Mammary Neoplasms, Animal; Matrix Metalloproteinase 14; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Oncogene Proteins; Phosphorylation; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; RNA, Small Interfering; Tyrosine; Wiskott-Aldrich Syndrome Protein, Neuronal | 2009 |
The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of beta-1,6-GlcNAc branching on HUVEC conformation.
Topics: Acetylglucosamine; Actin Cytoskeleton; Carbohydrate Conformation; Cell Shape; Cell Survival; Colonic Neoplasms; Culture Media, Conditioned; Cytoskeleton; Endothelial Cells; Enzyme Activation; Flow Cytometry; Glycosylation; HT29 Cells; Humans; Intercellular Junctions; Neoplasm Invasiveness; Permeability; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Polysaccharides; Protein Processing, Post-Translational; rhoA GTP-Binding Protein; Stress Fibers; Time Factors; Tyrosine | 2010 |
Collagen type I regulates beta-catenin tyrosine phosphorylation and nuclear translocation to promote migration and proliferation of gastric carcinoma cells.
Topics: Actins; Active Transport, Cell Nucleus; Antigens, CD; beta Catenin; Cadherins; Carcinoma; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Cell Shape; Collagen Type I; Cytoskeleton; Focal Adhesion Kinase 1; Humans; Neoplasm Invasiveness; Phosphorylation; PTEN Phosphohydrolase; Signal Transduction; Stomach Neoplasms; Time Factors; Tyrosine | 2010 |
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Membrane; Cell Movement; Glutathione Transferase; Guanine Nucleotide Exchange Factors; Mice; Microscopy, Fluorescence; Mutation; Neoplasm Invasiveness; NIH 3T3 Cells; Phosphorylation; Protein Structure, Tertiary; Rho Guanine Nucleotide Exchange Factors; Tyrosine | 2010 |
CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation.
Topics: Antigens, CD; Antigens, Neoplasm; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Cortactin; Extracellular Matrix; Humans; Immunoenzyme Techniques; Immunoprecipitation; Lymphatic Metastasis; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; Pancreatic Neoplasms; Phosphorylation; Prognosis; Protein Kinase C-delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Survival Rate; Tumor Cells, Cultured; Tyrosine | 2010 |
The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.
Topics: Actins; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Apoptosis; ATPases Associated with Diverse Cellular Activities; Cell Line, Tumor; Cell Movement; fas Receptor; Fas-Associated Death Domain Protein; Glioma; HEK293 Cells; Humans; LIM Domain Proteins; Lysophospholipids; Models, Biological; Neoplasm Invasiveness; Phosphorylation; Proteasome Endopeptidase Complex; Signal Transduction; Transcription Factor RelA; Transcription Factors; Tyrosine | 2010 |
Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement.
Topics: Biopsy; Breast Neoplasms; Cell Adhesion; Cytoskeleton; Epithelium; Female; Humans; Immunohistochemistry; Mesoderm; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Proteins; Tubulin; Twist-Related Protein 1; Tyrosine | 2010 |
Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Surface Extensions; Cells, Cultured; Fatty Acid-Binding Proteins; Female; Fluorescence Resonance Energy Transfer; Fluorescent Antibody Technique; Gelatin; Humans; Immunoenzyme Techniques; Immunoprecipitation; Mice; Mice, Nude; Microtubule-Associated Proteins; Minor Histocompatibility Antigens; Neoplasm Invasiveness; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; src-Family Kinases; Tyrosine; Wiskott-Aldrich Syndrome Protein, Neuronal | 2010 |
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.
Topics: Actins; Adaptor Proteins, Signal Transducing; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cortactin; Cytoskeleton; Female; Humans; Neoplasm Invasiveness; Oncogene Proteins; Phosphorylation; Protein Binding; Pseudopodia; src Homology Domains; Tyrosine | 2010 |
Serine phosphorylation of NPM-ALK, which is dependent on the auto-activation of the kinase activation loop, contributes to its oncogenic potential.
Topics: Cell Line, Tumor; Enzyme Activation; Humans; Neoplasm Invasiveness; Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Tyrosine | 2011 |
MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition.
Topics: Amino Acid Sequence; Animals; Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Humans; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mucin-1; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Snail Family Transcription Factors; Transcription Factors; Tyrosine | 2011 |
Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.
Topics: Animals; Annexin A2; Antibodies, Monoclonal; Antigens, Neoplasm; Biomarkers, Tumor; Blotting, Western; Cancer Vaccines; Cell Line, Tumor; Cell Membrane; Cell Movement; Disease-Free Survival; Epithelial-Mesenchymal Transition; Female; Humans; Liver; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Pancreatic Neoplasms; Phosphorylation; RNA Interference; Tumor Cells, Cultured; Tyrosine | 2011 |
STAT6 expression in glioblastoma promotes invasive growth.
Topics: Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Databases, Factual; Epidermal Growth Factor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Glioma; Humans; Neoplasm Invasiveness; Phosphorylation; RNA, Small Interfering; STAT6 Transcription Factor; Survival Analysis; Tyrosine | 2011 |
Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.
Topics: Animals; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; Hydrazones; Immunoprecipitation; Mammary Neoplasms, Animal; Mice; Mice, SCID; Microscopy, Fluorescence, Multiphoton; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Rats; Receptor, ErbB-3; Signal Transduction; Sulfonamides; Transplantation, Heterologous; Tyrosine | 2012 |
Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility.
Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Down-Regulation; Doxycycline; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha2; Lipoproteins; Matrix Metalloproteinases; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Plasminogen Activators; Protein Isoforms; RNA Interference; Signal Transduction; Tyrosine | 2011 |
Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.
Topics: Animals; Cell Adhesion Molecules; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Green Fluorescent Proteins; Humans; Mice; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Signal Transduction; src Homology Domains; Tyrosine | 2011 |
Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Oncogene Proteins; Phosphorylation; RNA, Messenger; Signal Transduction; Tumor Burden; Tyrosine; Xenograft Model Antitumor Assays | 2011 |
Relationship between thiol, tyrosine nitration and carbonyl formation as biomarkers of oxidative stress and changes of hemostatic function of plasma from breast cancer patients before surgery.
Topics: Adult; Aged; Antioxidants; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Female; Hemostasis; Humans; Middle Aged; Neoplasm Invasiveness; Nitrosation; Oxidative Stress; Protein Carbonylation; Sulfhydryl Compounds; Tyrosine | 2012 |
Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma; Cell Movement; Cytoskeletal Proteins; Female; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2012 |
Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers.
Topics: Adenocarcinoma, Papillary; Cell Proliferation; Dasatinib; High-Throughput Screening Assays; Humans; Metabolome; Molecular Targeted Therapy; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2012 |
Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation.
Topics: Antigens, CD; Blotting, Western; Cadherins; Capillaries; Cell Adhesion; Cell Membrane Permeability; Cell Movement; Cell Proliferation; Cells, Cultured; Cortactin; Endothelium, Vascular; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Immunoprecipitation; Mutation; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Signal Transduction; src-Family Kinases; Tyrosine; Vascular Endothelial Growth Factor A | 2012 |
SRC kinase regulation in progressively invasive cancer.
Topics: Cell Line, Tumor; Humans; Kinetics; Male; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Signal Transduction; src-Family Kinases; Tyrosine | 2012 |
Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
Topics: AC133 Antigen; Animals; Antigens, CD; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Movement; Cell Survival; Gene Expression Regulation, Neoplastic; Glycoproteins; HSP27 Heat-Shock Proteins; Humans; Hypoxia; Intracellular Signaling Peptides and Proteins; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplastic Stem Cells; p38 Mitogen-Activated Protein Kinases; Peptides; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Signal Transduction; Tyrosine | 2012 |
The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Proliferation; ErbB Receptors; Fluorescent Antibody Technique; Humans; Immunoprecipitation; Liver Neoplasms; Membrane Proteins; Neoplasm Invasiveness; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2013 |
Src activation by β-adrenoreceptors is a key switch for tumour metastasis.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Female; Humans; Mice; Models, Molecular; Neoplasm Invasiveness; Neoplasm Metastasis; Norepinephrine; Ovarian Neoplasms; Phosphorylation; Phosphoserine; Receptors, Adrenergic, beta; Signal Transduction; src-Family Kinases; Stress, Physiological; Survival Analysis; Tyrosine | 2013 |
Invasive behaviour of glioblastoma cell lines is associated with altered organisation of the cadherin-catenin adhesion system.
Topics: Adaptor Proteins, Signal Transducing; Adherens Junctions; Animals; Astrocytes; beta Catenin; Brain Neoplasms; Cadherins; Cell Adhesion; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Glioblastoma; Humans; Membrane Proteins; Microscopy, Confocal; Microscopy, Electron, Scanning; Neoplasm Invasiveness; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Vesicular Transport Proteins | 2002 |
CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells.
Topics: Adjuvants, Immunologic; Bone Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chondrosarcoma; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hyaluronan Receptors; Hyaluronic Acid; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Phosphorylation; Plasminogen Activator Inhibitor 1; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Up-Regulation; Urokinase-Type Plasminogen Activator | 2002 |
Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion.
Topics: Animals; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplasm Invasiveness; Phosphatidic Acids; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; rhoA GTP-Binding Protein; Tyrosine | 2003 |
Heparanase mediates cell adhesion independent of its enzymatic activity.
Topics: Animals; Cell Adhesion; Cell Membrane; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Endothelium; Extracellular Matrix; Glucuronidase; Lymphoma; Mice; Neoplasm Invasiveness; Oligopeptides; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2003 |
Specific amino acid dependency regulates invasiveness and viability of androgen-independent prostate cancer cells.
Topics: Amino Acids; Androgens; Animals; Apoptosis; Cell Adhesion; Cell Cycle; Cell Division; Cell Line, Tumor; DNA Fragmentation; Flow Cytometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Phenylalanine; Phosphorylation; Prostatic Neoplasms; Protein-Tyrosine Kinases; Tyrosine | 2003 |
Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.
Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Mitogens; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-met; Survival Rate; Tumor Cells, Cultured; Tyrosine | 2003 |
The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo.
Topics: Animals; beta-Lactamases; Blotting, Western; Cell Adhesion; Cell Division; Cell Movement; Female; Fibroblasts; Hepatocyte Growth Factor; Humans; Male; Mice; Mice, Nude; Mitogens; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphoproteins; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-met; Survival Rate; Tumor Cells, Cultured; Tyrosine | 2003 |
Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.
Topics: Actins; Adaptor Proteins, Signal Transducing; Agar; Animals; Calmodulin-Binding Proteins; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cytoskeleton; ErbB Receptors; Fibroblasts; Glutathione Transferase; GRB2 Adaptor Protein; Ligands; Microscopy, Fluorescence; Models, Biological; Mutation; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Retroviridae; Signal Transduction; src Homology Domains; Tyrosine | 2003 |
Tyrosine kinase, p56lck-induced cell motility, and urokinase-type plasminogen activator secretion involve activation of epidermal growth factor receptor/extracellular signal regulated kinase pathways.
Topics: Blotting, Western; Cell Line, Tumor; Cell Movement; DNA, Complementary; Genes, Dominant; Humans; Hypoxia; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; Neoplasm Invasiveness; Phosphorylation; Plasmids; Precipitin Tests; Protein-Tyrosine Kinases; Signal Transduction; Time Factors; Transfection; Tyrosine; Urokinase-Type Plasminogen Activator | 2004 |
Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Female; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, CXCR4; Tyrosine | 2004 |
Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro.
Topics: Angiogenesis Inhibitors; Animals; Capillaries; Cattle; CD13 Antigens; Cell Division; Cell Line, Tumor; Cells, Cultured; Disulfides; Dose-Response Relationship, Drug; Endothelial Cells; Fibroblast Growth Factor 2; In Vitro Techniques; Inhibitory Concentration 50; Models, Chemical; Neoplasm Invasiveness; Neovascularization, Pathologic; Porifera; Tyrosine | 2004 |
Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src.
Topics: 3T3 Cells; Aniline Compounds; Animals; Antineoplastic Agents; CSK Tyrosine-Protein Kinase; Dioxoles; Mice; Models, Molecular; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Nude; src-Family Kinases; Structure-Activity Relationship; Tyrosine; Xenograft Model Antitumor Assays | 2004 |
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Topics: Carcinoma, Papillary; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Collagen; Collagen Type I; DNA; Drug Combinations; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Laminin; Neoplasm Invasiveness; Osteopontin; Phenotype; Phosphorylation; Protein Structure, Tertiary; Proteoglycans; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sialoglycoproteins; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2004 |
Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness.
Topics: beta Catenin; Biological Assay; Cadherins; Cell Line; Colonic Neoplasms; Cyclin D1; Cytoskeletal Proteins; Deoxycholic Acid; Gene Expression Regulation; Humans; Neoplasm Invasiveness; Phosphorylation; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Small Interfering; Signal Transduction; Trans-Activators; Tyrosine; Urokinase-Type Plasminogen Activator | 2004 |
Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells.
Topics: Carcinoma; Cell Movement; Diet; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Luteolin; Matrix Metalloproteinases; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Quercetin; Subcellular Fractions; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2004 |
Interplay between scatter factor receptors and B plexins controls invasive growth.
Topics: Alkaline Phosphatase; Animals; Antigens, CD; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Collagen; COS Cells; Drug Combinations; Humans; Laminin; Membrane Glycoproteins; Mice; Neoplasm Invasiveness; NIH 3T3 Cells; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-met; Semaphorins; Tyrosine | 2004 |
SU5416 is a potent inhibitor of hepatocyte growth factor receptor (c-Met) and blocks HGF-induced invasiveness of human HepG2 hepatoma cells.
Topics: 3T3 Cells; Animals; Carcinoma, Hepatocellular; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expression; Hepatocyte Growth Factor; Hepatocytes; Humans; Indoles; Liver Neoplasms; Mice; Neoplasm Invasiveness; Oncogene Proteins, Fusion; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyrroles; Tyrosine | 2004 |
Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion.
Topics: beta Catenin; Blotting, Northern; Cadherins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Intercellular Junctions; Mouth Neoplasms; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Signal Transduction; Trans-Activators; Tyrosine | 2004 |
Listeria monocytogenes produces a pro-invasive factor that signals via ErbB2/ErbB3 heterodimers.
Topics: Blotting, Western; Cell Line, Tumor; Collagen Type I; Colonic Neoplasms; Humans; Immunoprecipitation; Listeria monocytogenes; Listeriosis; Neoplasm Invasiveness; Phosphorylation; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Tyrosine | 2005 |
Identification and phenotypic characterization of a subpopulation of T84 human colon cancer cells, after selection on activated endothelial cells.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Communication; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Metalloproteases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phenotype; Phosphorylation; src-Family Kinases; Tyrosine; Umbilical Veins | 2005 |
Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: novel heregulin/HER3-stimulated signaling pathway in glioma.
Topics: Focal Adhesion Kinase 2; Genes, Dominant; Glioma; Humans; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neuregulin-1; Neuregulins; Phosphorylation; Protein-Tyrosine Kinases; Receptor, ErbB-3; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2005 |
CEACAM1 enhances invasion and migration of melanocytic and melanoma cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Integrin alphaVbeta3; Integrin beta3; Melanocytes; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Oligopeptides; Protein Structure, Tertiary; Time Factors; Transfection; Tyrosine; Up-Regulation | 2004 |
Signaling mechanisms that mediate invasion in prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Immunoprecipitation; Laminin; Male; Neoplasm Invasiveness; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Proteoglycans; Quinazolines; Receptors, Androgen; Signal Transduction; Transfection; Tyrosine | 2004 |
The role of nitric oxide synthases and nitrotyrosine in retinoblastoma.
Topics: Child, Preschool; Cohort Studies; Female; Humans; Immunoenzyme Techniques; Infant; Male; Neoplasm Invasiveness; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Retinal Neoplasms; Retinoblastoma; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2005 |
Correlation between 99mTc-(V)-DMSA uptake and constitutive level of phosphorylated focal adhesion kinase in an in vitro model of cancer cell lines.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Focal Adhesion Protein-Tyrosine Kinases; Humans; In Vitro Techniques; Ions; Kinetics; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphates; Phosphorylation; Prognosis; Radiopharmaceuticals; Technetium Tc 99m Dimercaptosuccinic Acid; Time Factors; Tyrosine | 2005 |
Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma.
Topics: Biopsy; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Erythropoietin; Gene Expression Regulation; Head and Neck Neoplasms; Humans; Hypoxia; Immunohistochemistry; Immunoprecipitation; Janus Kinase 2; Laminin; Models, Statistical; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Proto-Oncogene Proteins; Receptors, Erythropoietin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrosine | 2005 |
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.
Topics: Animals; Binding Sites; Cell Line, Transformed; Cell Movement; Cells, Cultured; Collagen; Cytoskeletal Proteins; Drug Combinations; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Injections, Subcutaneous; Laminin; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Oncogene Protein v-crk; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Retroviridae Proteins, Oncogenic; src Homology Domains; Tyrosine | 2005 |
Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.
Topics: Cell Division; Cell Line, Tumor; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Gangliosides; Humans; Melanoma; Neoplasm Invasiveness; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; RNA, Small Interfering; Sialyltransferases; Transfection; Tyrosine | 2005 |
FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation.
Topics: Animals; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Dynamins; Endocytosis; Extracellular Matrix; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Humans; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 2005 |
Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells.
Topics: Caspases; Caspases, Initiator; Cell Line, Tumor; Cell Proliferation; Choriocarcinoma; Female; Gene Expression Profiling; Humans; Interleukin-6; Leukemia Inhibitory Factor; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Peptide Hydrolases; Phosphorylation; Pregnancy; Signal Transduction; STAT3 Transcription Factor; Tissue Inhibitor of Metalloproteinase-1; Tyrosine | 2005 |
Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.
Topics: Actins; Agar; Androstadienes; Animals; Anoikis; Binding Sites; Cell Adhesion; Cell Cycle; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Collagen; Crk-Associated Substrate Protein; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gelatin; Genes, Dominant; Immunoblotting; Immunoprecipitation; Laminin; Matrix Metalloproteinase 2; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Paxillin; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Talin; Time Factors; Transfection; Tyrosine; Vinculin; Wortmannin | 2005 |
Collagen XVII promotes integrin-mediated squamous cell carcinoma transmigration--a novel role for alphaIIb integrin and tirofiban.
Topics: Adult; Antineoplastic Agents; Autoantigens; Carcinoma, Squamous Cell; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Chemotaxis; Collagen Type XVII; Epithelium; Humans; Integrin alpha5beta1; Kalinin; Keratinocytes; Neoplasm Invasiveness; Non-Fibrillar Collagens; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Protein Structure, Tertiary; Tirofiban; Tyrosine; Wound Healing | 2006 |
Macrophage activation increases the invasive properties of hepatoma cells by destabilization of the adherens junction.
Topics: Adherens Junctions; Animals; beta Catenin; Cadherins; Carcinoma, Hepatocellular; Cell Movement; Culture Media, Conditioned; Down-Regulation; ErbB Receptors; Humans; Interleukins; Liver Neoplasms; Macrophage Activation; Macrophages, Peritoneal; Mice; Neoplasm Invasiveness; Phosphorylation; Pyrimidines; src-Family Kinases; Tyrosine | 2006 |
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Movement; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Hepatocyte Growth Factor; Humans; Mice; Neoplasm Invasiveness; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-met; Tyrosine | 2006 |
Androgen induction of prostate cancer cell invasion is mediated by ezrin.
Topics: Amino Acid Substitution; Androgens; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Collagen; Cytoskeletal Proteins; Drug Combinations; Humans; Laminin; Male; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Proteoglycans; Threonine; Tyrosine | 2006 |
Photodynamic therapy suppresses the migration and invasion of head and neck cancer cells in vitro.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Movement; Cell Survival; Collagen; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Head and Neck Neoplasms; Humans; Laminin; Light; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Photochemotherapy; Photosensitizing Agents; Proteoglycans; Signal Transduction; src-Family Kinases; Tyrosine | 2007 |
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.
Topics: Annexin A5; Antineoplastic Agents; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Glioma; Humans; Neoplasm Invasiveness; Phosphorylation; Tyrosine | 2007 |
Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion.
Topics: Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Chemokine CXCL12; Chemokines, CXC; Flow Cytometry; Fluorescent Antibody Technique; Glycosaminoglycans; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphorylation; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Stromal Cells; Syndecan-1; Syndecan-2; Syndecan-4; Tyrosine | 2007 |
p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism.
Topics: Base Sequence; Carcinoma, Squamous Cell; Catenins; Cell Adhesion Molecules; Cell Line, Tumor; Delta Catenin; DNA Primers; Epidermal Growth Factor; Humans; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Recombinant Proteins; RNA, Small Interfering; Tyrosine | 2007 |
Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells.
Topics: Adenocarcinoma; Amino Acid Motifs; Amino Acid Sequence; Animals; Antigens, Neoplasm; beta Catenin; Binding Sites; Cell Line, Tumor; Cell Nucleus; Female; Humans; Mass Spectrometry; Mice; Mice, Nude; Molecular Sequence Data; Mucin-1; Mucins; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Receptor, Platelet-Derived Growth Factor beta; Tyrosine | 2007 |
[Molecular mechanism of gastrin increasing colon cancer cells' invasion].
Topics: Benzodiazepinones; Blotting, Western; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Humans; Neoplasm Invasiveness; Phenylurea Compounds; Phosphorylation; Receptor, Cholecystokinin B; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tyrosine | 2007 |
Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1.
Topics: Amino Acid Sequence; Animals; Caveolin 1; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Cell Movement; Cytoskeleton; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Galectin 3; Humans; Macromolecular Substances; Mice; N-Acetylglucosaminyltransferases; Neoplasm Invasiveness; Nerve Tissue Proteins; Phosphorylation; Protein Binding; Protein Transport; Tyrosine | 2008 |
Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.
Topics: Amino Acid Substitution; Animals; Cell Movement; Endothelial Cells; Ephrin-A1; Guanine Nucleotide Exchange Factors; Mice; Mice, Transgenic; Mutation, Missense; Neoplasm Invasiveness; Neovascularization, Pathologic; Neuropeptides; Peptide Mapping; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-vav; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Receptor, EphA2; Signal Transduction; Tyrosine | 2008 |
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.
Topics: Benzoquinones; Carcinoma, Squamous Cell; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hepatocyte Growth Factor; Humans; In Vitro Techniques; Integrins; Lactams, Macrocyclic; Mouth Neoplasms; Neoplasm Invasiveness; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.
Topics: alpha Catenin; Benzoquinones; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Aggregation; Cell Line; Culture Techniques; Cytoskeletal Proteins; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Fibroblasts; Fluorescent Antibody Technique; Gels; Humans; Lactams, Macrocyclic; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine; Vanadates | 1995 |
Inhibition of collagenolytic activity relates to quantitative reduction of invasion in vitro in a c-Ha-ras transfected glial cell line.
Topics: Amides; Animals; Basement Membrane; Cell Line, Transformed; Cell Movement; Chick Embryo; Collagen; Cricetinae; Culture Media, Conditioned; Culture Media, Serum-Free; Dipeptides; Drug Combinations; Gelatinases; Heart; Laminin; Mesocricetus; Myocardium; Neoplasm Invasiveness; Neoplasm Proteins; Neuroglia; Protease Inhibitors; Proteoglycans; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Transfection; Tyrosine | 1994 |
Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells.
Topics: alpha Catenin; beta Catenin; Cadherins; Cell Adhesion; Cytoskeletal Proteins; Desmoplakins; Epidermal Growth Factor; gamma Catenin; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Phosphorylation; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1994 |
Attachment, invasion, chemotaxis, and proteinase expression of B16-BL6 melanoma cells exhibiting a low metastatic phenotype after exposure to dietary restriction of tyrosine and phenylalanine.
Topics: Animals; Cell Adhesion; Chemotaxis; Diet; Melanoma, Experimental; Metalloendopeptidases; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Phenylalanine; Plasminogen Activators; Receptors, Fibronectin; Tyrosine | 1996 |
Inhibition of in vitro tumor cell invasion by ginsenoside Rg3.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carbohydrate Sequence; Carcinoma, Small Cell; Ginsenosides; Humans; Liver Neoplasms, Experimental; Lung Neoplasms; Lysophospholipids; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Phosphorylation; Rats; Rats, Inbred Strains; Saponins; Tyrosine | 1996 |
Malignant melanoma of the head and neck. Clinical and immunological considerations.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antibodies, Neoplasm; Biomarkers, Tumor; Disease Progression; Disease-Free Survival; Female; Head and Neck Neoplasms; Humans; Israel; Male; Melanoma; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Scalp; Sex Factors; Skin Neoplasms; Sunlight; Tyrosine | 1996 |
Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells.
Topics: Animals; beta Catenin; Cytoskeletal Proteins; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Receptor, ErbB-2; Recombinant Proteins; Sequence Deletion; Signal Transduction; Stomach Neoplasms; Trans-Activators; Transfection; Transforming Growth Factor alpha; Transplantation, Heterologous; Tyrosine | 1996 |
alpha2,6-Sialyltransferase gene transfection into a human glioma cell line (U373 MG) results in decreased invasivity.
Topics: Animals; Antigens, CD; beta-D-Galactoside alpha 2-6-Sialyltransferase; Cell Adhesion; Cell Adhesion Molecules; Cloning, Molecular; Collagen; Cytoskeleton; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioma; Humans; Integrin alpha3beta1; Integrins; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Receptors, Laminin; Sialic Acids; Sialyltransferases; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine | 1997 |
A novel variant of human Grb7 is associated with invasive esophageal carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Alternative Splicing; Amino Acid Sequence; Base Sequence; Carcinoma, Squamous Cell; Cell Movement; ErbB Receptors; Esophageal Neoplasms; GRB2 Adaptor Protein; GRB7 Adaptor Protein; Humans; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Proteins; RNA, Antisense; Sequence Homology, Amino Acid; Signal Transduction; src Homology Domains; Tumor Cells, Cultured; Tyrosine | 1998 |
Genistein suppresses adhesion-induced protein tyrosine phosphorylation and invasion of B16-BL6 melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Genistein; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 1998 |
Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion.
Topics: Antigens, CD; Cell Adhesion; Cell Movement; Clone Cells; Cytokines; Cytoskeleton; Extracellular Matrix; Flow Cytometry; Fluorescent Antibody Technique; Hepatocyte Growth Factor; Humans; Integrin beta1; Integrin beta3; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Platelet Membrane Glycoproteins; Proto-Oncogene Proteins c-met; Signal Transduction; Thyroid Gland; Tumor Cells, Cultured; Tyrosine | 1998 |
Suppression of adhesion-induced protein tyrosine phosphorylation decreases invasive and metastatic potentials of B16-BL6 melanoma cells by protein tyrosine kinase inhibitor genistein.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1997 |
Cytoplasmic redistribution of E-cadherin-catenin adhesion complex is associated with down-regulated tyrosine phosphorylation of E-cadherin in human bronchopulmonary carcinomas.
Topics: Adenocarcinoma; alpha Catenin; beta Catenin; Cadherins; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cytoskeletal Proteins; Down-Regulation; Humans; Lung Neoplasms; Macromolecular Substances; Neoplasm Invasiveness; Phosphorylation; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1998 |
Tissue-specific expression of beta-catenin in normal mesenchyme and uveal melanomas and its effect on invasiveness.
Topics: 3T3 Cells; Adenomatous Polyposis Coli; Adult; Animals; beta Catenin; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Cell Membrane; Cytoplasm; Cytoskeletal Proteins; Dogs; Epithelium; Glycogen Synthase Kinase 3; Humans; Melanoma; Mesoderm; Mice; Neoplasm Invasiveness; Phenotype; Phosphorylation; Protein Tyrosine Phosphatases; Staining and Labeling; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Uveal Neoplasms; Vanadates | 1998 |
Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor.
Topics: Aged; Animals; Female; Gallbladder Neoplasms; Hepatocyte Growth Factor; Humans; Kringles; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Transplantation; Phosphorylation; Proto-Oncogene Proteins c-met; Tumor Cells, Cultured; Tyrosine; Urokinase-Type Plasminogen Activator | 1998 |
Met overexpression confers HGF-dependent invasive phenotype to human thyroid carcinoma cells in vitro.
Topics: Carcinoma; Cell Division; Cell Movement; Drug Resistance, Neoplasm; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Phenotype; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine; Wound Healing | 1999 |
RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion.
Topics: Breast Neoplasms; Female; Focal Adhesion Kinase 2; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Humans; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neuregulin-1; Nuclear Proteins; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; ras-GRF1; Receptor, ErbB-2; Repressor Proteins; Tyrosine | 2000 |
Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase.
Topics: Actins; Amides; Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cytoskeletal Proteins; Drug Interactions; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; rho-Associated Kinases; Tumor Cells, Cultured; Tyrosine | 2000 |
Inhibition of B16BL6 melanoma invasion by tyrosine and phenylalanine deprivation is associated with decreased secretion of plasminogen activators and increased plasminogen activator inhibitors.
Topics: Animals; Cell Adhesion; Culture Media, Conditioned; Melanoma; Mice; Neoplasm Invasiveness; Phenylalanine; Plasminogen Activators; Plasminogen Inactivators; Tissue Plasminogen Activator; Tumor Cells, Cultured; Tyrosine; Urokinase-Type Plasminogen Activator | 1999 |
(+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Catechin; Cell Division; Cytoskeleton; Enterocytes; Enzyme Activation; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Intestinal Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Stereoisomerism; Tumor Cells, Cultured; Tyrosine | 2001 |
Decreased tissue plasminogen activator and increased plasminogen activator inhibitors and increased activator protein-1 and specific promoter 1 are associated with inhibition of invasion in human A375 melanoma deprived of tyrosine and phenylalanine.
Topics: Cell Adhesion; Culture Media, Conditioned; Fibroblasts; Humans; Infant; Melanoma; Neoplasm Invasiveness; Phenylalanine; Plasminogen Activators; Plasminogen Inactivators; Skin; Sp1 Transcription Factor; Tissue Plasminogen Activator; Transcription Factor AP-1; Tumor Cells, Cultured; Tyrosine; Urokinase-Type Plasminogen Activator | 2001 |
Alkyl-lysophospholipid 1-O-octadecyl-2-O-methyl- glycerophosphocholine induces invasion through episialin-mediated neutralization of E-cadherin in human mammary MCF-7 cells in vitro.
Topics: Antibodies, Monoclonal; beta Catenin; Biotinylation; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Aggregation; Cell Membrane; Cell Survival; Collagen; Cytoskeletal Proteins; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoblotting; Microscopy, Confocal; Microscopy, Fluorescence; Mucin-1; Neoplasm Invasiveness; Phenotype; Phosphatidylcholines; Phospholipid Ethers; Phosphorylation; Precipitin Tests; Protein Binding; Radioimmunoassay; Signal Transduction; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2001 |
Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor.
Topics: Actins; Adherens Junctions; Animals; Cadherins; Cell Differentiation; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Dogs; Epithelial Cells; Mesoderm; Morphogenesis; Mutation; Neoplasm Invasiveness; Phosphorylation; Receptor, ErbB-2; Signal Transduction; Tyrosine | 2001 |
Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.
Topics: alpha 1-Antitrypsin; Animals; Apoptosis; Colonic Neoplasms; HT29 Cells; Humans; Immunohistochemistry; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Male; Mice; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Protein Precursors; Receptor, IGF Type 1; Tyrosine | 2001 |
Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion.
Topics: Amino Acid Motifs; Antigens, Surface; Cell Adhesion; Collagen; Cytoplasm; DNA, Complementary; Enzyme Activation; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Integrin alpha6beta4; Integrins; Intracellular Signaling Peptides and Proteins; Laminin; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polymerase Chain Reaction; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine | 2001 |
Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.
Topics: Cell Movement; Cloning, Molecular; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Insulin-Like Growth Factor I; Kinetics; Matrix Metalloproteinase 2; Mutagenesis, Site-Directed; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Phenotype; Protein Structure, Tertiary; Receptor, IGF Type 1; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 2001 |
The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant.
Topics: Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Extracellular Matrix; Fluorescent Antibody Technique; Hepatocyte Growth Factor; Humans; Male; Mitogens; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Prostatic Neoplasms; Tumor Cells, Cultured; Tyrosine | 2001 |
Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1alpha and epidermal growth factor.
Topics: Blotting, Western; Carcinoma; Cell Division; Cytoskeletal Proteins; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Interleukin-1; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Phenotype; Phosphoproteins; Phosphorylation; Translocation, Genetic; Tumor Cells, Cultured; Tyrosine | 2001 |
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
Topics: Amiloride; Animals; Blotting, Western; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibronectins; Immunoblotting; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pseudopodia; Rats; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine | 2002 |
Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells.
Topics: Agar; Animals; Antineoplastic Agents; Antioxidants; beta Catenin; Cadherins; Cell Line, Transformed; Cell Movement; Cytoskeletal Proteins; Hydrogen Peroxide; Intestinal Mucosa; Neoplasm Invasiveness; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Oxidative Stress; Phosphotyrosine; Pyrrolidines; Rats; Thiocarbamates; Trans-Activators; Transfection; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration.
Topics: Blotting, Western; Breast Neoplasms; Cell Movement; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Down-Regulation; Female; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Megakaryocytes; Neoplasm Invasiveness; Neuregulin-1; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, ErbB-2; Recombinant Proteins; Signal Transduction; src-Family Kinases; Transfection; Tumor Cells, Cultured; Tyrosine | 2002 |
Phosphorylated tyrosine-containing proteins in primary lung cancer correlates with proliferation and prognosis.
Topics: Aged; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Division; Disease-Free Survival; Female; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Staging; Phosphorylation; Prognosis; Proliferating Cell Nuclear Antigen; Tyrosine | 2002 |
Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells.
Topics: Actins; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Viral; Chickens; Culture Media; Extracellular Matrix; Fibroblasts; Fibronectins; Immunohistochemistry; Integrins; Membrane Proteins; Microscopy, Fluorescence; Microscopy, Immunoelectron; Morphogenesis; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Signal Transduction; Tyrosine | 1992 |
Effects of synthetic peptides and protease inhibitors on the interaction of a human ovarian cancer cell line (NIH:OVCAR-3) with a reconstituted basement membrane (Matrigel).
Topics: Amides; Amino Acid Sequence; Aminocaproates; Antineoplastic Agents; Benzamidines; Biocompatible Materials; Cell Adhesion; Cell Line; Chemotaxis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Female; Glycoproteins; Humans; In Vitro Techniques; Laminin; Leupeptins; Metalloendopeptidases; Molecular Sequence Data; Neoplasm Invasiveness; Oligopeptides; Ovarian Neoplasms; Pepstatins; Polyamines; Protease Inhibitors; Proteoglycans; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Tyrosine | 1991 |