tyrosine has been researched along with Insulin Sensitivity in 207 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (2.42) | 18.7374 |
| 1990's | 24 (11.59) | 18.2507 |
| 2000's | 104 (50.24) | 29.6817 |
| 2010's | 55 (26.57) | 24.3611 |
| 2020's | 19 (9.18) | 2.80 |
| Authors | Studies |
|---|---|
| Li, R; Qiao, J; Wang, S; Ye, Z; Zhang, C; Zhang, Y; Zhao, Y | 1 |
| Chepurny, OG; Collier, JJ; Cooney, RN; Holz, GG; Leech, CA; Meng, Q; Molnar, ME; Pruekprasert, N | 1 |
| Feng, L; Zhang, Y | 1 |
| Chen, X; Chen, Y; Jiang, R; Kou, X; Li, Y; Liu, Y; Sheng, L; Song, Y; Yu, D | 1 |
| Chen, S; Eguchi, M; Fukunaga, A; Kabe, I; Kochi, T; Miki, T; Mizoue, T; Nanri, A | 1 |
| Angot, B; Cormont, M; Cornejo, PJ; Gonzalez, T; Jager, J; Ohanna, M; Tanti, JF; Vergoni, B | 1 |
| Domínguez-Riscart, J; Durán-Ruiz, MC; González-Domínguez, Á; Lechuga-Sancho, AM; Mateos, RM; Saez-Benito, A; Visiedo, F | 1 |
| Han, JS; Park, JE | 1 |
| Araki, E; Cai, W; Fukuda, K; Fukuda, T; Igata, M; Kahn, CR; Kondo, T; Okagawa, S; Okubo, Y; Otsuka, Y; Sakaguchi, M; Sakaguchi, N; Sato, Y; Tseng, YH; Yamagata, K; Yoshizawa, T | 1 |
| Goto, T; Inoue, K; Inoue, Y; Kawada, T; Ng, SP; Nomura, W; Takahashi, H | 1 |
| Bakhtyukov, AA; Derkach, KV; Kuznetsova, VS; Shpakov, AO; Sorokoumov, VN; Zakharova, IO | 1 |
| Han, JS; Lim, HJ; Park, JE | 1 |
| Dong, X; Feng, B; Liu, H; Liu, Z; Xu, Y; Zhang, J | 1 |
| Barbieri, E; Cline, GW; Galuppo, B; Kien, CL; Li, Z; Samuels, SL; Santoro, N; Tricò, D; Umano, GR; Van Name, M; Wagner, DA | 1 |
| Kasuga, M | 1 |
| Bekhbat, M; Felger, JC; Goldsmith, DR; Haroon, E; Miller, AH; Treadway, MT; Woolwine, BJ | 1 |
| Hang, J; Hou, E; Qiao, J; Zhao, Y | 1 |
| Cai, D; Guo, F; Holm, L; Li, Y; Liu, HY; Zhang, K; Zhou, B | 1 |
| MacPherson, REK; Shamshoum, H; Tsiani, E; Vlavcheski, F | 1 |
| Dambrova, M; Grandane, A; Katkevics, M; Liepinsh, E; Makrecka-Kuka, M; Sevostjanovs, E; Videja, M; Vilks, K | 1 |
| Afridi, SK; Aftab, MF; Begum, S; Ghaffar, S; Hafizur, RM; Murtaza, M; Sara, S; Waraich, RS | 1 |
| Akbarpour, M; Gozal, D; Khalyfa, A; Maccari, R; Ottanà, R; Qiao, Z | 1 |
| Abate, ML; Bugianesi, E; Buzzigoli, E; Carli, F; Cassader, M; Ciociaro, D; Della Latta, V; Gaggini, M; Gambino, R; Gastaldelli, A; Marietti, M; Rosso, C | 1 |
| Al-Majdoub, M; Ali, A; Carstensen, B; Ridderstråle, M; Safai, N; Spégel, P; Suvitaival, T; Vestergaard, H | 1 |
| Takaguri, A | 1 |
| Kuusisto, J; Laakso, M; Smith, U; Stancáková, A; Vangipurapu, J | 1 |
| Cao, W; Guo, H; Hao, L; He, K; Li, X; Liu, L; Liu, R; Ma, Y; Sun, X; Wang, X; Yang, X; Yao, P | 1 |
| Ashida, H; Hiramitsu, M; Horio, F; Inoue, T; Iwai, H; Katagiri, T; Kobayashi, M; Matsuda, Y; Murai, A; Yamashita, Y | 1 |
| Dong, Y; Mitch, WE; Thomas, SS; Zhang, L | 1 |
| Brownell, LA; Corneliusen, B; Jia, Q; Pantier, M; Yimam, M; Zhao, J | 1 |
| Astolphi, RD; Bomfim, SR; Chiba, FY; Cintra, LT; Colombo, NH; Curbete, MM; Ervolino, E; Prieto, AK; Shirakashi, DJ; Sumida, DH | 1 |
| Lam, L; Nakano, D; Nishiyama, A; Ortiz, RM; Peti-Peterdi, J; Popovich, I; Rodriguez, R; Sonanez-Organis, JG; Thorwald, MA; Vázquez-Medina, JP; Viscarra, JA | 1 |
| D'Aquino, K; Feener, EP; King, GL; Li, Q; Maeda, Y; Mima, A; Mizutani, K; Park, K; Rask-Madsen, C; White, MF; Winnay, J | 1 |
| Bachelard, H; Badeau, M; Bourgoin, F; Larivière, R; Nadeau, A; Pitre, M | 1 |
| Bhanot, S; Böhm, C; Dagnell, M; Kappert, K; Kintscher, U; Krüger, J; Meyborg, H; Ostman, A; Stawowy, P; Trappiel, M | 1 |
| Chu, YL; Cui, Q; Gong, YD; Jiang, HY; Qu, HM; Su, ZH; Yu, HN | 1 |
| Han, SN; Kim, HK; Kim, JN | 1 |
| Ju, TJ; Kim, JY; Kim, YD; Kim, YW; Kwon, WY; Lee, IK; Park, SY | 1 |
| Kim, SH; Lee, JH; Park, JY; Park, S | 1 |
| Conceição, EP; Lisboa, PC; Moura, EG; Oliveira, E; Peixoto-Silva, N; Pinheiro, CR | 1 |
| Aylor, K; Barrett, EJ; Wang, AX; Wang, H | 1 |
| Bhattacharyya, S; Feferman, L; Tobacman, JK | 1 |
| Breaux, C; Kruger, C; Nguyen, TT; Stadler, K; Wicks, SE | 1 |
| Gong, YZ; Liao, DF; Liu, HY; Wang, J; Xie, XJ; Yang, HX; Zou, T | 1 |
| de la Monte, SM; Deochand, C; Tong, M; Yu, R | 1 |
| Hall, K; Lewitt, M; Melkersson, K | 1 |
| Hasegawa, H; Honda, T; Iwasa, M; Kobayashi, Y; Sumida, Y; Taguchi, O; Takei, Y; Togashi, K | 1 |
| Harder, U; Hellmuth, C; Kirchberg, FF; Koletzko, B; Lass, N; Peissner, W; Reinehr, T | 1 |
| Bao, Y; Chen, T; Hu, C; Huang, F; Jia, W; Ma, X; Ni, Y; Rajani, C; Zhao, A; Zheng, X | 1 |
| Ärnlöv, J; Berne, C; Brandmaier, S; Broeckling, CD; Fall, T; Ganna, A; Giedraitis, V; Gieger, C; Ingelsson, E; Lind, L; Magnusson, PK; Meitinger, T; Nowak, C; Pedersen, NL; Peters, A; Prenni, JE; Ripatti, S; Salihovic, S; Strauch, K; Sundström, J; Tukiainen, T; Wang-Sattler, R | 1 |
| Cimino, F; Ferrari, D; Fratantonio, D; Molonia, MS; Saija, A; Speciale, A; Virgili, F | 1 |
| Bachelard, H; Badeau, M; Bourgoin, F; Larivière, R; Mélançon, S; Nadeau, A; Pitre, M | 1 |
| Adochio, R; Draznin, B; Kim, T; Wayne Leitner, J | 1 |
| Bai, X; Dong, LQ; Liu, F; Liu, FY; Liu, M; Liu, X; Ramos, F; Richardson, A; Van Remmen, H; Zhang, J | 1 |
| Dong, LQ; Fang, Q; Jia, W; Liu, F; Liu, M; Liu, X; Zhang, J; Zhou, L | 1 |
| Cho, KW; Morris, DL; Rui, L; Zhou, Y | 1 |
| Huang, DW; Shen, SC; Wu, JS | 1 |
| Li, R; Li, YX; Qiu, DS; Wei, DP; Xiong, DM; Xu, LZ; Zhang, J | 1 |
| Sim, MK; Sim, SZ; Tsi, D; Wong, YC; Xu, XG | 1 |
| Beck-Nielsen, H; Bowen, B; Højlund, K; Langlais, P; Lefort, N; Levin, K; Mandarino, LJ; Yi, Z | 1 |
| Huang, T; Liu, HQ; Qin, B; Zhu, QR | 1 |
| Charbonneau, A; Marette, A | 1 |
| Cha, HN; Kim, JY; Kim, YD; Kim, YW; Min, KN; Park, SY; Song, IH | 1 |
| Anuradha, CV; Kannappan, S; Palanisamy, N | 1 |
| Bao, Y; Li, H; Yu, Y; Zhang, X | 1 |
| Bergheim, I; Bischoff, SC; Kanuri, G; Spruss, A; Uebel, K | 1 |
| Choi, KD; Chun, KH; Ciaraldi, TP; Henry, RR; Jung, Y; Kim, YB; Lee, DH | 1 |
| Charbonneau, A; Dallaire, P; Kapur, S; Marette, A; Perreault, M; Pilon, G; White, PJ | 1 |
| Barbour, LA; Friedman, JE; Hernandez, TL; McCurdy, CE | 1 |
| Brasnyó, P; Cseh, J; Halmai, R; Laczy, B; Markó, L; Mérei, A; Mészáros, LG; Mikolás, E; Mohás, M; Molnár, GA; Sümegi, B; Szijártó, IA; Wittmann, I | 1 |
| Bjekic-Macut, J; Bozic, I; Damjanovic, S; Djukic, T; Lissounov, A; Macut, D; Matic, M; Petakov, M; Pljesa-Ercegovac, M; Savic-Radojevic, A; Simic, T; Suvakov, S | 1 |
| Habiro, M; Kaneki, M; Kim, M; Mao, J; Martyn, JA; Shimizu, N; Shinozaki, S; Sugita, H; Sugita, M; Yasuda, Y; Yasuhara, S | 1 |
| Chang, HW; Hwang, SL; Lee, JY; Li, X | 1 |
| Bonini, MG; Cleland, E; Kadiiska, MB; Ruggiero, C; Stadler, K; Wicks, S | 1 |
| Adams, SH | 1 |
| Boller, S; Boschetti, N; Item, F; Joblin, BA; Niessen, M; Spinas, GA; Trüb, T; Xu, L | 1 |
| Blough, ER; Kakarla, SK; Katta, A; Kolli, MB; Kundla, S; Manne, ND; Nalabotu, SK; Wu, M | 1 |
| Cano, C; Decara, JM; Fresno, N; Macias-González, M; Pavón, FJ; Pérez-Fernández, R; Rivera, P; Rodríguez de Fonseca, F; Romero-Cuevas, M; Serrano, A; Suárez, J; Vida, M | 1 |
| Anuradha, CV; Arunkumar, E | 1 |
| Ala-Korpela, M; Kähönen, M; Kangas, AJ; Lehtimäki, T; Raitakari, OT; Rönnemaa, T; Soininen, P; Viikari, JS; Würtz, P | 1 |
| Anuradha, CV; Bhuvaneswari, S | 1 |
| Bidel, S; Carstensen, M; Erlund, I; Herder, C; Kempf, K; Koenig, W; Kuha, S; Martin, S; Roden, M; Sundvall, J; Tuomilehto, J | 1 |
| Gogg, S; Smith, U | 1 |
| Dey, CS; Kumar, N | 3 |
| Amaral, ME; Bertelli, DF; Boschero, AC; Carneiro, EM; Carvalho, CR; Marangoni, S; Saad, MJ; Toyama, MH; Ueno, M; Velloso, LA | 1 |
| Klover, PJ; Mooney, RA; Nowak, IA; Senn, JJ | 1 |
| Liu, HX | 1 |
| Furuhashi, M; Higashiura, K; Hyakukoku, M; Murakami, H; Shimamoto, K; Togashi, N; Ura, N; Wang, L; Yamaguchi, K | 1 |
| Carvalheira, JB; de Carvalho-Filho, MA; Pereira-Da-Silva, M; Saad, MJ; Torsoni, MA; Velloso, LA | 1 |
| Anai, M; Asano, T; Fujishiro, M; Fukushima, Y; Honda, M; Inukai, K; Katagiri, H; Kikuchi, M; Ogihara, T; Oka, Y; Onishi, Y; Ono, H; Sakoda, H; Shojima, N | 1 |
| Barres, R; Gonzalez, T; Grémeaux, T; Gual, P; Le Marchand-Brustel, Y; Tanti, JF | 1 |
| Calderón, V; Reynoso, R; Salgado, LM | 1 |
| Abdalla Saad, MJ; Alvarez-Rojas, F; Carvalheira, JB; Carvalho, CR; Dolnikoff, MS; Hirata, AE | 1 |
| Alonso, A; Fernández, R; González, C; Patterson, AM | 1 |
| Hirata, AE; Rojas, FA; Saad, MJ | 1 |
| Nagaev, I; Rotter, V; Smith, U | 1 |
| Carvalheira, JB; Hirata, AE; Saad, MJ; Thirone, AC; Velloso, LA | 1 |
| Huang, DM; Huang, GY; Lu, F | 1 |
| de Alvaro, C; Hernandez, R; Lorenzo, M; Teruel, T | 1 |
| Fujie, H; Kimura, S; Koike, K; Miyoshi, H; Moriya, K; Shintani, Y; Tsukamoto, K; Tsutsumi, T | 1 |
| Accili, D; Carnemolla, R; Han, S; Liang, CP; Okamoto, H; Tabas, I; Tall, AR | 1 |
| Cline, GW; Davies, PJ; Leibowitz, MD; Shen, Q; Shulman, GI | 1 |
| Bajotto, G; Nagasaki, M; Oshida, Y; Qin, B; Ren, M; Sato, Y | 1 |
| Haj, FG; Kahn, BB; Kim, HJ; Kim, JK; Kim, YB; Neel, BG; Shulman, GI; Zabolotny, JM | 1 |
| Chu, YL; Li, HF; Qiu, HY; Sun, YY | 1 |
| Befroy, D; Bilz, S; Elder, BD; Liu, ZX; Qu, X; Romanelli, AJ; Samuel, VT; Shulman, GI | 1 |
| Kahn, CR; Kondo, T; Ueki, K | 1 |
| Chaudry, IH; Holland, LT; Keeton, AB; Ma, Y; Messina, JL; Toth, B | 1 |
| Chang, YY; Cheng, JT; Liu, IM; Lo, CY; Pai, HH; Su, CF | 1 |
| Brown, KK; Carrick, KM; Chen, L; Clifton, LG; McNulty, JA; Pahel, GL; Stimpson, SA; Strum, JC; Winegar, DA; Yang, B | 1 |
| Araújo, EP; Boschero, AC; De Souza, CT; Gasparetti, AL; Saad, MJ; Ueno, M; Velloso, LA | 1 |
| Auricchio, A; Beguinot, F; Cotugno, G; Formisano, P; Linher, K; Pollock, R | 1 |
| Barreca, A; Johansen, T; Laurino, C; Malmlöf, K | 1 |
| Gual, P; Le Marchand-Brustel, Y; Tanti, JF | 1 |
| Adrogue, JV; Brown, KK; Burgmaier, M; Golfman, LS; Guthrie, PH; Sharma, S; Taegtmeyer, H; Van Arsdall, M; Wilson, CR; Young, ME | 1 |
| Chu, YL; Li, HF; Li, M; Qiu, HY; Sun, YY | 1 |
| Gu, XF; Kuang, JQ; Wang, ZC; Yang, DZ | 1 |
| Ali, N; Ebina, Y; Fujita, Y; Ishizawa, K; Izawa, Y; Kanematsu, Y; Obata, T; Tamaki, T; Tomita, S; Tsuchiya, K; Yoshizumi, M | 1 |
| Adeli, K; Jia, Z; Liu, L; Mielke, JG; Taghibiglou, C; Wang, YT; Zhang, Y | 1 |
| Endo, Y; Fujita, T; Horita, S; Kadowaki, T; Kunimi, M; Li, Y; Sakamoto, K; Seki, G; Terauchi, Y; Tobe, K; Yamada, H; Zheng, Y | 1 |
| Carrick, KM; Clifton, LG; Lin, P; McNulty, JA; Pahel, GL; Stimpson, SA; Strum, JC; Winegar, DA; Yang, B | 1 |
| Bo, S; Cassader, M; Gambino, R; Gentile, L; Guidi, S; Pagani, A; Pagano, GF | 1 |
| Mehdi, MZ; Srivastava, AK | 1 |
| Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P | 1 |
| Bukhari, A; Haruta, T; He, J; Hiratani, K; Ishizuka, K; Iwata, M; Kanatani, Y; Kobayashi, M; Sasaoka, T; Usui, I | 1 |
| Brady, MJ; Makinen, MW; Mustafi, D; Ou, H; Yan, L | 1 |
| Belfort, R; Berria, R; De Filippis, EA; Finlayson, J; Kashyap, S; Mandarino, LJ; Pratipanawatr, T; Richardson, DK; Wang, L | 1 |
| Bae, DS; Bae, YS; Jang, MK; Jin, DK; Longo, N; Park, HS; Park, JW; Shin, SM | 1 |
| Brown, KK; Carrick, K; Chen, L; Clifton, LG; Geske, R; Han, B; McNulty, JA; Pahel, G; Qian, Y; Stimpson, SA; Strum, J; Triantafillou, JA; Yang, B | 1 |
| Gupte, A; Mora, S | 1 |
| Itoh, Y; Mori, Y; Obata, T; Tajima, N | 1 |
| Cao, YL; Li, S; Liu, HY; Ruan, CM; Wang, LL; Xu, C; Zhou, XB | 1 |
| Kawakami, Y; Kokusho, Y; Komaru, T; Koshida, R; Miyazawa, T; Nakayama, M; Shimokawa, H; Shirato, K; Takahashi, K; Takeda, M; Takeda, S; Yamaguchi, N | 1 |
| Ariga, M; Cho, Y; Furuhata, Y; Hakuno, F; Kimura, K; Nishihara, M; Rho, JY; Takahashi, S; Uchijima, Y; Yamanouchi, K | 1 |
| Bujo, H; Murakami, K; Saito, Y; Shibasaki, M; Takahashi, K; Unoki, H | 1 |
| Cormont, M; Grémeaux, T; Jager, J; Le Marchand-Brustel, Y; Tanti, JF | 1 |
| Benito, M; Clampit, JE; Escribano, O; Gonzalez-Rodriguez, A; Rondinone, CM; Valverde, AM | 1 |
| Bujo, H; Hashimoto, N; Ishikawa, K; Saito, Y; Takahashi, K; Yagui, K | 1 |
| Ceriello, A; Ciotola, M; Esposito, K; Giannetti, G; Giugliano, D; Misso, L; Schisano, B | 1 |
| Koike, K; Matsuura, Y; Miyamoto, H; Miyamura, T; Moriishi, K; Moriya, K; Murata, S; Suzuki, T; Tanaka, K | 1 |
| Li, JS; Li, N; Li, WQ; Wang, XD; Yan, XW | 1 |
| Bukhari, A; Fujisaka, S; Haruta, T; Ishizuka, K; Kanatani, Y; Kishimoto, T; Kobayashi, M; Naka, T; Urakaze, M; Usui, I | 1 |
| Cao, W; Collins, QF; Liu, HY; Liu, Z; Lupo, EG; Moukdar, F; Xiong, Y | 1 |
| Ben, DF; Chen, XL; Ge, SD; Tang, HT; Wei, D; Xia, ZF | 1 |
| Peng, W; Qu, HM; Ye, YH; Zhan, Y | 1 |
| Biroli, G; Bo, S; Cassader, M; De Michieli, F; Durazzo, M; Gambino, R; Musso, G; Pagano, G; Premoli, A | 1 |
| Gao, H; Li, X; Lv, W; Ning, G; Shen, Y; Yang, J; Yang, Y; Zhang, Z | 1 |
| Arul Suyambunathan, V; Bobby, Z; Selvaraj, N; Sridhar, MG; Vinayagamoorthi, R | 1 |
| Giacca, A; Guan, X; Oprescu, AI; Park, E; Wong, V | 1 |
| Blouet, C; Huneau, JF; Mariotti, F; Mathe, V; Tome, D | 1 |
| Gorden, P; Grunberger, G; Zick, Y | 1 |
| Freychet, P; Le Marchand-Brustel, Y; Monier, S | 1 |
| Berti, L; Häring, H; Kellerer, M; Kiehn, R; Kroder, G; Mosthaf, L; Tippmer, S | 1 |
| Budavari, A; Hotamisligil, GS; Murray, D; Spiegelman, BM | 1 |
| Gorden, P; Levy-Toledano, R; Roach, P; Taouis, M; Taylor, SI | 1 |
| Araki, E; Brüning, JC; Haag, B; Johnson, RS; Kahn, CR; Lipes, MA; Patti, ME | 1 |
| Egawa, K; Hasegawa, M; Ide, R; Iwanishi, M; Kashiwagi, A; Kikkawa, R; Maegawa, H; Shigeta, Y; Ugi, S | 1 |
| Danielsen, AG; Hosomi, Y; Liu, F; Roth, RA; Shii, K | 1 |
| Feinstein, R; Hemi, R; Kanety, H; Karasik, A; Papa, MZ | 1 |
| Goldfine, ID; Maddux, BA; Moller, DE; Reaven, GM; Sbraccia, P | 1 |
| Backer, JM; Folli, F; Kahn, CR; Saad, MJ | 1 |
| Saad, MJ | 1 |
| Aizawa, S; Akanuma, Y; Kaburagi, Y; Kadowaki, T; Sonenberg, N; Takahashi, Y; Tamemoto, H; Tobe, K; Ueki, K; Yamamoto-Honda, R; Yamauchi, T; Yazaki, Y; Yoshizawa, F | 1 |
| Lee, J; Pilch, PF; Stephens, JM | 1 |
| Elhanany, E; Hemi, R; Kanety, H; Karasik, A; LeRoith, D; Paz, K; Zick, Y | 1 |
| Anai, M; Asano, T; Fukushima, Y; Funaki, M; Inukai, K; Katagiri, H; Kikuchi, M; Ogihara, T; Oka, Y; Terasaki, J; Yazaki, Y | 1 |
| Derouet, M; Dupont, J; Simon, J; Taouis, M | 1 |
| Bryer-Ash, M; Cheung, AT; Coy, DH; Fuselier, J; Kolls, JK; Ree, D | 1 |
| Anai, M; Asano, T; Fukushima, Y; Funaki, M; Inukai, K; Kanda, A; Kikuchi, M; Nawano, M; Ogihara, T; Oka, Y; Onishi, Y; Sakoda, H; Yazaki, Y | 1 |
| Barucci, N; Bell, K; Cline, GW; Goodyear, LJ; Griffin, ME; Kraegen, EW; Lee, D; Marcucci, MJ; Shulman, GI; White, MF | 1 |
| Kahn, CR; Landaker, EJ; Patti, ME; Virkamäki, A; Yki-Järvinen, H | 1 |
| Clemont, A; Feener, EP; Hein, KD; Igarashi, M; Jiang, ZY; King, GL; Lin, YW; White, MF; Yamauchi, T | 1 |
| Choi, WS; Heart, E; Sung, CK | 1 |
| Boitard, C; Caillat-Zucman, S; Dubois-Laforgue, D; Timsit, J | 1 |
| Azevedo, JL; Cortright, RN; Dohm, GL; Itani, SI; Pories, WJ; Sinha, M; Zhou, Q | 1 |
| Baynes, KC; Beeton, CA; Hansen, T; O'Rahilly, S; Panayotou, G; Shepherd, PR; Simpson, H; Soos, M; Stein, R; Whitehead, JP | 1 |
| Carvalho, E; Rondinone, C; Smith, U | 1 |
| Broschat, K; Chen, X; Gulve, EA; Hope, HR; McMahon, EG; Ross, SA; Sun, S | 1 |
| Bryer-Ash, M; Cheung, AT; Kolls, JK; Ree, D; Wang, J | 1 |
| Brown, KK; Glass, CK; Li, AC; Palinski, W; Silvestre, MJ; Willson, TM | 1 |
| Carvalho, CR; Paez-Espinosa, V; Rojas, FA; Saad, MJ | 1 |
| Hirose, M; Kaneki, M; Martyn, JA; Sugita, H; Yasuhara, S | 1 |
| Fantus, IG; Goldstein, BJ; Lai, R; Le-Tien, H; Shin, P; Tang, S | 1 |
| Aguirre, V; Corbould, A; Dunaif, A; Kim, JK; Lee, A; Rui, L; Shulman, GI; White, MF | 1 |
| Anai, M; Ando, K; Asano, T; Chiba, Y; Fujishiro, M; Fujita, T; Fukushima, Y; Inukai, K; Kikuchi, M; Ogihara, T; Onishi, Y; Ono, H; Sakoda, H; Sekine, N; Shojima, N | 1 |
| Akca, H; Dixon, JE; Donner, DB; Gustin, JA; Maehama, T; Mayo, LD; Ozes, ON | 1 |
| Marette, A; Tremblay, F | 1 |
| Goldfine, ID; Kozlowski, M; Li, M; Maddux, BA; Manchem, VP; Youngren, JF; Zhang, BB | 1 |
| Hevener, AL; Janez, A; Olefsky, J; Reichart, D | 1 |
| Goto, T; Häkkinen, AM; Halavaara, J; Korsheninnikova, E; Seppälä-Lindroos, A; Vehkavaara, S; Virkamäki, A; Yki-Järvinen, H | 1 |
| Adams, JM; Berria, R; Cusi, K; DeFronzo, RA; Jenkinson, CP; Maezono, K; Mandarino, LJ; Pratipanawatr, T; Pratipanawatr, W | 1 |
| Auwerx, J; Bac, P; Blanchard, SG; Champy, MF; Desreumaux, P; Dubuquoy, L; Gelman, L; Leesnitzer, LM; Moras, D; Picard, F; Plunket, KD; Potier, N; Renaud, JP; Rocchi, S; Vamecq, J; Zeyer, D | 1 |
| Bizeau, ME; Kang, J; Pagliassotti, MJ; Sung, CK; Thresher, JS | 1 |
| Hemi, R; Kanety, H; Karasik, A; Paz, K; Wertheim, N; Zick, Y | 1 |
| Hart, GW; Lane, MD; Vosseller, K; Wells, L | 1 |
| Allibardi, S; Bendinelli, P; Luzi, L; Maroni, P; Piccoletti, R; Samaja, M; Terruzzi, I; Vesco, F | 1 |
| Chikara, S; Fukuda, N; Hu, WY; Kanmatsuse, K; Kishioka, H; Nakayama, M; Teng, J | 1 |
| Abe, M; Anai, M; Ando, K; Asano, T; Fujishiro, M; Fujita, T; Fukushima, Y; Kikuchi, M; Ogihara, T; Onishi, Y; Ono, H; Sakoda, H; Shojima, N | 1 |
| Cohen, O; Nadiv, O; Zick, Y | 1 |
| Kahn, CR; Saad, MJ | 1 |
| Grunberger, G; Levy, J; Nagy, K | 1 |
| Ciaraldi, TP; Freidenberg, GR; Molina, JM; Olefsky, JM; Thies, RS | 1 |
| Capeau, J; Capony, JP; Caron, M; Grigorescu, F; Magré, J; Mirouze, J; Picard, J; Reynet, C; White, MF | 1 |
| Ermel, B; Häring, H; Herberg, L; Hölzl, J; Kirsch, D; Machicao, F; Mushack, J; Obermaier, B; Rattenhuber, E; Su, Z | 1 |
| Cahill, GF; Felig, P; Marliss, E | 1 |
8 review(s) available for tyrosine and Insulin Sensitivity
| Article | Year |
|---|---|
Structure and function of the insulin receptor-a personal perspective.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding Sites; Humans; Insulin; Insulin Resistance; Mutation; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 2019 |
[Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction].
Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Atorvastatin; Diabetes Mellitus; Dual-Specificity Phosphatases; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase Phosphatases; Phosphorylation; rho-Associated Kinases; rhoA GTP-Binding Protein; Serine; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2018 |
Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.
Topics: Adult; Aged; Aged, 80 and over; Bile Acids and Salts; Caffeine; Diabetes Mellitus, Type 2; Fatty Acids, Monounsaturated; Glucose; Glucose Tolerance Test; Glycerophospholipids; Humans; Insulin; Insulin Resistance; Insulin Secretion; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Tyrosine | 2016 |
Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amino Acids, Aromatic; Amino Acids, Sulfur; Animals; Cysteine; Cystine; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Methionine; Models, Biological; Obesity; Oxidation-Reduction; Oxidative Stress; Phenylalanine; Transaminases; Tyrosine | 2011 |
From signal transduction to signal interpretation: an alternative model for the molecular function of insulin receptor substrates.
Topics: Animals; Binding Sites; Diabetes Mellitus, Type 2; Gene Expression Regulation; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Models, Biological; Protein Binding; Protein Structure, Tertiary; Receptor, Insulin; Signal Transduction; Tyrosine | 2012 |
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
Topics: AMP-Activated Protein Kinases; Animals; Fatty Acids, Nonesterified; Gene Expression Regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Multienzyme Complexes; Peroxisome Proliferator-Activated Receptors; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoid X Receptors; Serine; Signal Transduction; Stress, Physiological; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Molecular mechanisms of insulin resistance.
Topics: Amino Acid Sequence; Animals; Dexamethasone; Diabetes Mellitus, Experimental; Fasting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Mice; Molecular Sequence Data; Muscles; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Inbred SHR; Receptor, Insulin; Tyrosine | 1994 |
Alterations in insulin receptor and substrate phosphorylation in hypertensive rats.
Topics: Animals; Hypertension; Insulin Resistance; Phosphorylation; Rats; Rats, Inbred SHR; Receptor, Insulin; Substrate Specificity; Tyrosine | 1992 |
5 trial(s) available for tyrosine and Insulin Sensitivity
| Article | Year |
|---|---|
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.
Topics: Aged; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Leucine; Lysophospholipids; Male; Mass Spectrometry; Metabolome; Metabolomics; Metformin; Middle Aged; Mitochondria; Tyrosine; Valine | 2018 |
Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.
Topics: Adult; Blood Platelets; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Insulin Resistance; Male; Middle Aged; Oxidative Stress; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Resveratrol; Signal Transduction; Stilbenes; Tyrosine | 2011 |
Insulin resistance in non-obese women with polycystic ovary syndrome: relation to byproducts of oxidative stress.
Topics: Adult; Antioxidants; Body Mass Index; Female; Humans; Insulin Resistance; Malondialdehyde; Oxidative Stress; Oxidoreductases; Polycystic Ovary Syndrome; Tyrosine; Uric Acid | 2011 |
Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Female; Glyburide; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipoprotein Lipase; Male; Middle Aged; Oxidative Stress; Pioglitazone; Postprandial Period; Thiazolidinediones; Time Factors; Triglycerides; Tyrosine | 2006 |
Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects.
Topics: Adipose Tissue; Adult; Animals; Biological Transport; Cell Fractionation; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Humans; Hydrogen Peroxide; Immunoblotting; Insulin; Insulin Resistance; Membrane Proteins; Obesity; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Temperature; Tyrosine; Vanadates; Wheat Germ Agglutinins | 1990 |
194 other study(ies) available for tyrosine and Insulin Sensitivity
| Article | Year |
|---|---|
Amino acid signatures in relation to polycystic ovary syndrome and increased risk of different metabolic disturbances.
Topics: Alanine; Amino Acids; Body Mass Index; Female; Glycine; Humans; Insulin Resistance; Lysine; Metabolic Syndrome; Obesity; Polycystic Ovary Syndrome; Tyrosine | 2022 |
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Resistance; Male; Mice; Mice, Knockout; Nicotinic Agonists; Pyridines; Sitagliptin Phosphate; Tyrosine | 2022 |
Thyroid-Stimulating Hormone Inhibits Insulin Receptor Substrate-1 Expression and Tyrosyl Phosphorylation in 3T3-L1 Adipocytes by Increasing NF-
Topics: 3T3-L1 Cells; Adipocytes; Animals; Dose-Response Relationship, Drug; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; NF-kappa B; Phosphorylation; Protein Binding; Thyrotropin; Tumor Necrosis Factor-alpha; Tyrosine | 2022 |
Berberine Improves TNF-α-Induced Hepatic Insulin Resistance by Targeting MEKK1/MEK Pathway.
Topics: Berberine; Humans; Insulin; Insulin Resistance; Isoquinolines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Molecular Docking Simulation; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Tumor Necrosis Factor-alpha; Tyrosine | 2022 |
Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan.
Topics: Alanine; Animals; Humans; Insulin; Insulin Resistance; Isoleucine; Japan; Methionine; Obesity; Overweight; Prospective Studies; Thinness; Tyrosine; Valine | 2022 |
The Stress-Responsive microRNA-34a Alters Insulin Signaling and Actions in Adipocytes through Induction of the Tyrosine Phosphatase PTP1B.
Topics: Adipocytes; Animals; Insulin; Insulin Resistance; Mice; Mice, Obese; MicroRNAs; Obesity; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Tyrosine | 2022 |
Catalase post-translational modifications as key targets in the control of erythrocyte redox homeostasis in children with obesity and insulin resistance.
Topics: Antioxidants; Biotin; Catalase; Chromatography, Liquid; Erythrocytes; Homeostasis; Humans; Insulin Resistance; Nitric Oxide; Obesity; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Reactive Oxygen Species; Tandem Mass Spectrometry; Tyrosine | 2022 |
HM-Chromanone, a Major Homoisoflavonoid in
Topics: Glucose; Glucose Transporter Type 4; Glycogen; Glycogen Synthase Kinase 3; Humans; I-kappa B Kinase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoflavones; JNK Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Muscle, Skeletal; Palmitates; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphorylation; Portulaca; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Serine; Tyrosine | 2022 |
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
Topics: Adipocytes; Animals; Diabetes Mellitus, Type 2; Homeostasis; Insulin; Insulin Resistance; Male; Mice; Phosphorylation; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Threonine; Tyrosine | 2022 |
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
Topics: Adipocytes; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mechanistic Target of Rapamycin Complex 1; Phosphoproteins; Pyruvaldehyde; Serine; Signal Transduction; Tyrosine | 2022 |
[Characterization and biological activity of new 4-oxo-1,4-dihydrocinnoline-based inhibitors of the tyrosine phosphatase PTP1B and TCPTP].
Topics: Animals; Enzyme Inhibitors; Glucose; Insulin; Insulin Resistance; Leptin; Obesity; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Rats; Rats, Wistar; T-Lymphocytes; Tyrosine | 2022 |
HM-chromanone from Portulaca oleracea L. inhibits protein tyrosine phosphatase 1B and mitigates glucose production in insulin-resistant HepG2 cells.
Topics: Glucose; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Molecular Docking Simulation; Molecular Structure; Phosphatidylinositol 3-Kinases; Portulaca; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine | 2023 |
Virtual Screening and Biological Evaluation of Novel Low Molecular Weight Protein Tyrosine Phosphatase Inhibitor for the Treatment of Insulin Resistance.
Topics: Enzyme Inhibitors; Humans; Insulin Resistance; Molecular Weight; Obesity; Phosphatidylinositol 3-Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Tyrosine | 2023 |
Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity.
Topics: Adolescent; Child; Cross-Sectional Studies; Female; Fermentation; Ghrelin; Humans; Insulin; Insulin Resistance; Insulin, Regular, Human; Lactulose; Male; Pediatric Obesity; Tyrosine | 2023 |
Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia.
Topics: Anhedonia; C-Reactive Protein; Depression; Depressive Disorder, Major; Humans; Insulin Resistance; Phosphatidylinositol 3-Kinases; Tyrosine | 2020 |
Metabolomics and correlation network analysis of follicular fluid reveals associations between l-tryptophan, l-tyrosine and polycystic ovary syndrome.
Topics: Adult; Female; Follicular Fluid; Gas Chromatography-Mass Spectrometry; Humans; Insulin Resistance; Metabolic Networks and Pathways; Metabolome; Metabolomics; Obesity; Polycystic Ovary Syndrome; Tryptophan; Tyrosine | 2021 |
Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis.
Topics: Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenase; Animals; Cells, Cultured; Disease Models, Animal; Fatty Acids; Gene Expression Regulation, Enzymologic; Hepatocytes; Histones; Insulin Resistance; Linoleic Acids, Conjugated; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; Oxidation-Reduction; PPAR alpha; Signal Transduction; Transcriptional Activation; Tyrosine | 2021 |
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models, Animal; Enzyme Activation; Glucose Transporter Type 4; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Phosphorylation; Plant Extracts; Rats; Rosmarinus; Serine; TOR Serine-Threonine Kinases; Tyrosine | 2021 |
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
Topics: Animals; Carnitine; CHO Cells; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Resistance; Models, Biological; Phosphorylation; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Tyrosine | 2021 |
Clove and Its Active Compound Attenuate Free Fatty Acid-Mediated Insulin Resistance in Skeletal Muscle Cells and in Mice.
Topics: Animals; Benzodioxoles; Chromatography, Liquid; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Flowers; Glucose; Glucose Tolerance Test; Glycogen Synthase Kinase 3; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Secreting Cells; Mice; Mice, Inbred BALB C; Muscle Fibers, Skeletal; Myoblasts, Skeletal; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Syzygium; Tyrosine | 2017 |
Protein-Tyrosine Phosphatase-1B Mediates Sleep Fragmentation-Induced Insulin Resistance and Visceral Adipose Tissue Inflammation in Mice.
Topics: Adipose Tissue, White; Animals; Eating; Hypothalamus; Inflammation; Insulin; Insulin Resistance; Intra-Abdominal Fat; Leptin; Macrophages; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor, Insulin; Signal Transduction; Sleep Deprivation; STAT3 Transcription Factor; Tyrosine; Weight Gain | 2017 |
Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance.
Topics: Adult; Age Factors; Amino Acids; Biomarkers; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Humans; Insulin Resistance; Isoleucine; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity; Prognosis; Reference Values; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Tyrosine | 2018 |
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine | 2019 |
Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues.
Topics: Adipose Tissue; Animals; Body Weight; Cytokines; Diet, High-Fat; Dietary Supplements; Energy Intake; Gluconeogenesis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Leucine; Liver; Male; Muscle, Skeletal; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Coffee; Diabetes Mellitus, Experimental; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Mice; Muscle, Skeletal; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Signal Transduction; Tyrosine | 2012 |
Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.
Topics: Animals; Cell Line; Cytokines; Disease Models, Animal; Gene Expression Profiling; Glucose Intolerance; I-kappa B Kinase; Inflammation Mediators; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Nephrectomy; NF-kappa B; Oligonucleotide Array Sequence Analysis; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Receptors, Immunologic; Renal Insufficiency, Chronic; RNA Interference; Signal Transduction; Time Factors; Transfection; Tyrosine | 2013 |
UP780, a chromone-enriched aloe composition improves insulin sensitivity.
Topics: 3T3-L1 Cells; Adiponectin; Aloe; Animals; Benzophenones; Blood Glucose; Chemistry, Pharmaceutical; Chromones; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucosides; Humans; Insulin; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Phytotherapy; Plant Preparations; Polysaccharides; Tyrosine | 2013 |
Periapical lesions decrease insulin signal and cause insulin resistance.
Topics: Adipose Tissue, White; Animals; Dental Pulp Exposure; Dental Pulp Necrosis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Leukocytes, Mononuclear; Male; Neutrophils; Periapical Diseases; Phosphorylation; Rats; Rats, Wistar; Receptor, Insulin; Serine; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Topics: Aldehydes; Angiotensin II Type 1 Receptor Blockers; Animals; Catalase; Citrate (si)-Synthase; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Imidazoles; Insulin Resistance; Male; Membrane Glycoproteins; Mitochondria, Heart; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; NF-E2-Related Factor 2; Obesity; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Inbred OLETF; Receptor, Angiotensin, Type 1; RNA, Messenger; Signal Transduction; Succinate Dehydrogenase; Superoxide Dismutase; Tetrazoles; Time Factors; Tyrosine | 2013 |
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Topics: Angiotensin II; Animals; Cattle; Cell Line; Endothelial Cells; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Zucker; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2013 |
Effects of tempol on endothelial and vascular dysfunctions and insulin resistance induced by a high-fat high-sucrose diet in the rat.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Mass Index; Cyclic N-Oxides; Diet, High-Fat; Dietary Sucrose; Endothelin-1; Endothelins; Endothelium, Vascular; Glucose; Glucose Transporter Type 4; Heart Rate; Hemodynamics; Inflammation; Insulin; Insulin Resistance; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Spin Labels; Tyrosine | 2013 |
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.
Topics: Adipose Tissue; Animals; Cell Line; Diet, High-Fat; Insulin; Insulin Resistance; Liver; Male; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Oligonucleotides, Antisense; Organ Specificity; Phenotype; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Receptor, Insulin; Signal Transduction; Tyrosine | 2013 |
Relationship between tyrosine phosphorylation and protein expression of insulin receptor and insulin resistance in gestational diabetes mellitus.
Topics: Adult; Blood Glucose; Blotting, Western; Diabetes, Gestational; Fasting; Female; Humans; Insulin; Insulin Resistance; Muscle, Skeletal; Phosphorylation; Pregnancy; Radioimmunoassay; Receptor, Insulin; Tyrosine | 2014 |
Phytic acid and myo-inositol support adipocyte differentiation and improve insulin sensitivity in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Blood Glucose; Cell Differentiation; Glucose Transporter Type 4; Hypoglycemic Agents; Inositol; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Metabolism; Mice; Phytic Acid; PPAR gamma; RNA, Messenger; Tyrosine | 2014 |
Hemin improves insulin sensitivity in skeletal muscle in high fat-fed mice.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Body Weight; Cytokines; Depression, Chemical; Diet, High-Fat; Gene Expression; Glucose; Glucose Clamp Technique; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heme Oxygenase (Decyclizing); Hemin; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Liver; Male; Mice, Inbred C57BL; Muscle, Skeletal; Superoxide Dismutase; Triglycerides; Tyrosine | 2014 |
Plasma levels of lysine, tyrosine, and valine during pregnancy are independent risk factors of insulin resistance and gestational diabetes.
Topics: Adult; Aging; Asian People; Blood Glucose; Blood Pressure; Diabetes, Gestational; Diet; Energy Intake; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Lysine; Pregnancy; Risk Factors; Tyrosine; Valine | 2015 |
Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring.
Topics: Animals; Animals, Newborn; Antioxidants; Bilirubin; Catalase; Dose-Response Relationship, Drug; Fatty Liver; Female; Glutathione Peroxidase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lactation; Liver; Male; Maternal Exposure; Nicotine; Oxidative Stress; Protein Carbonylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serum Albumin; Signal Transduction; Superoxide Dismutase; Triglycerides; Tyrosine | 2015 |
Caveolin-1 phosphorylation regulates vascular endothelial insulin uptake and is impaired by insulin resistance in rats.
Topics: Animals; Caveolin 1; CSK Tyrosine-Protein Kinase; Diet, High-Fat; Endothelial Cells; Insulin; Insulin Resistance; Interleukin-6; Male; Microscopy, Fluorescence; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha; Tyrosine | 2015 |
Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1.
Topics: Animals; Carrageenan; GATA2 Transcription Factor; Gene Expression; GRB10 Adaptor Protein; Hep G2 Cells; Humans; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Models, Statistical; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Serine; Signal Transduction; Tyrosine | 2015 |
Diet-induced obesity and kidney disease - In search of a susceptible mouse model.
Topics: Animals; Diet; Disease Models, Animal; Insulin Resistance; Lipid Metabolism; Male; Mice; Mitochondria; Nitric Oxide Synthase Type II; Obesity; Oxidative Stress; Renal Insufficiency, Chronic; Tyrosine | 2016 |
Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes.
Topics: Animals; Cell Line; CHO Cells; Cloning, Molecular; Cricetulus; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Hepatocytes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Insulin; Insulin Resistance; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Engineering; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Receptors, Fc; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 2015 |
Differential Contributions of Alcohol and the Nicotine-Derived Nitrosamine Ketone (NNK) to Insulin and Insulin-Like Growth Factor Resistance in the Adolescent Rat Brain.
Topics: Acetylcholinesterase; Animals; Atrophy; Dinoprost; Drug Synergism; Ethanol; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Insulin Resistance; Male; Maze Learning; Nicotine; Nitrosamines; Oxidative Stress; Phosphorylation; Protein Carbonylation; Rats; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Somatomedins; Spatial Learning; tau Proteins; Temporal Lobe; Tyrosine | 2015 |
Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics.
Topics: Adult; Amino Acids; Antipsychotic Agents; Chromatography, Ion Exchange; Clopenthixol; Clozapine; Cohort Studies; Female; Glutamic Acid; Haloperidol; Humans; Insulin Resistance; Male; Middle Aged; Perphenazine; Prospective Studies; Psychotic Disorders; Schizophrenia; Thioridazine; Tyrosine | 2015 |
Associations among circulating branched-chain amino acids and tyrosine with muscle volume and glucose metabolism in individuals without diabetes.
Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Female; Humans; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Japan; Male; Middle Aged; Multivariate Analysis; Muscle Development; Regression Analysis; Sex Characteristics; Statistics, Nonparametric; Tyrosine | 2016 |
Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children.
Topics: Adolescent; Amino Acids, Branched-Chain; Child; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Life Style; Male; Metabolomics; Obesity; Tyrosine | 2016 |
Tryptophan Predicts the Risk for Future Type 2 Diabetes.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; China; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Isoleucine; Leucine; Longitudinal Studies; Male; Middle Aged; Phenylalanine; Predictive Value of Tests; Prognosis; Risk Factors; Tryptophan; Tyrosine; Valine | 2016 |
Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors.
Topics: Anthocyanins; Antioxidants; Cells, Cultured; Endothelium, Vascular; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Palmitic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Tyrosine | 2017 |
Endothelial and vascular dysfunctions and insulin resistance in rats fed a high-fat, high-sucrose diet.
Topics: Animals; Blood Pressure; Blotting, Western; Body Weight; Deoxyglucose; Diet; Dietary Fats; Endothelin-1; Endothelium, Vascular; Fatty Acids, Nonesterified; Fluorescent Antibody Technique; Glucose Clamp Technique; Heart Rate; Insulin; Insulin Resistance; Male; Obesity; Organ Size; Rats; Rats, Sprague-Dawley; Sucrose; Triglycerides; Tyrosine; Vascular Diseases; Vascular Resistance | 2008 |
Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Deoxyglucose; Gene Knockdown Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mitochondrial Diseases; Mitogen-Activated Protein Kinase 8; Phosphatidylinositol 3-Kinases; Phosphorylation; Serine; Tyrosine | 2009 |
Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Blotting, Western; Caloric Restriction; Down-Regulation; Glucose Tolerance Test; GRB2 Adaptor Protein; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Knockout; Muscle, Skeletal; Oncogene Protein v-akt; Phosphorylation; Signal Transduction; Tyrosine | 2009 |
Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Autophagy; Disease Models, Animal; Down-Regulation; Endoplasmic Reticulum; Humans; Insulin Resistance; Leupeptins; Mice; Mice, Inbred Strains; Obesity; Phosphorylation; Receptor, Insulin; Taurochenodeoxycholic Acid; Tyrosine | 2009 |
SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.
Topics: Adipose Tissue; Animals; Brain; Chlorocebus aethiops; COS Cells; Dietary Fats; Female; Glucose; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Nuclear Proteins; Phosphoproteins; Phosphorylation; Signal Transduction; Transcription Factors; Tyrosine | 2009 |
Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes.
Topics: Animals; Caffeic Acids; Cell Line; Cinnamates; Glucose; Hepatocytes; Insulin Resistance; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptor, Insulin; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
[Autophosphorylation of erythrocyte insulin receptors in patients with polycystic ovary syndrome].
Topics: Adult; Antigens, CD; Case-Control Studies; Erythrocytes; Female; Humans; Insulin Resistance; Phosphorylation; Polycystic Ovary Syndrome; Receptor, Insulin; Tyrosine; Young Adult | 2009 |
Hypoglycemic action of chicken meat extract in type-2 diabetic KKAy mice and GK rats.
Topics: Animals; Blood Glucose; Chickens; Diabetes Mellitus, Type 2; Dietary Proteins; Glucose Tolerance Test; Hyperglycemia; Insulin; Insulin Resistance; Male; Meat; Mice; Phosphorylation; Rats; Tyrosine | 2009 |
Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle.
Topics: Adult; Binding Sites; Catalysis; Cohort Studies; Female; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Mitochondrial Proton-Translocating ATPases; Muscle, Skeletal; Muscles; Phosphorylation; Tyrosine | 2010 |
[Expression of insulin receptor substrate-2 and its tyrosine phosphorylation in the hepatic tissue of chronic hepatitis B patients].
Topics: Case-Control Studies; Female; Hepatitis B, Chronic; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Phosphorylation; Tyrosine | 2010 |
Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins.
Topics: Animals; Crosses, Genetic; DNA Primers; Enzyme Induction; Fat Emulsions, Intravenous; Female; Glucose; Glucose Clamp Technique; Hyperinsulinism; Infusions, Intravenous; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Proto-Oncogene Proteins c-akt; RNA; Signal Transduction; Tyrosine | 2010 |
Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Weight; Cytokines; Gene Deletion; Glucose Clamp Technique; Hyperinsulinism; Inflammation; Insulin Resistance; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nitric Oxide Synthase Type II; Oxygen Consumption; Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats.
Topics: 2,4-Dinitrophenol; Aldehydes; Animals; Antioxidants; Apoptosis; Blood Glucose; Diet; Flavanones; Fructose; Hepatocytes; Insulin; Insulin Resistance; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2010 |
Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-κB pathway in rat aorta.
Topics: Animals; Anticoagulants; Aorta; Blotting, Western; Emulsions; Endothelium, Vascular; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Heparin; I-kappa B Proteins; Immunohistochemistry; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type III; Phospholipids; Phosphorylation; Protein Kinase C-alpha; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Soybean Oil; Tyrosine | 2011 |
Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice.
Topics: Aldehydes; Animals; Cells, Cultured; Coculture Techniques; Endotoxins; Fatty Liver; Fructokinases; Fructose; Glutathione; I-kappa B Proteins; Insulin Resistance; Kupffer Cells; Lipid Peroxidation; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Toll-Like Receptor 4; Transcription, Genetic; Triglycerides; Tumor Necrosis Factor-alpha; Tyrosine; Weight Gain | 2011 |
In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes.
Topics: Actin Depolymerizing Factors; Adult; Biotransformation; Blotting, Western; Body Mass Index; Cytoskeletal Proteins; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Middle Aged; Muscle, Skeletal; Obesity; Phosphorylation; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Tyrosine | 2011 |
Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle.
Topics: Animals; Endotoxemia; Endotoxins; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Muscle, Skeletal; Nitric Oxide Synthase Type II; Nitrogen; Obesity; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Rats; Sepsis; Signal Transduction; Tyrosine | 2010 |
Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum.
Topics: Adult; Biomarkers; Blood Glucose; Blotting, Western; Diabetes, Gestational; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Infant, Newborn; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle, Skeletal; Phosphorylation; Postpartum Period; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; RNA; Serine; Signal Transduction; Tyrosine | 2011 |
Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice.
Topics: Animals; Blood Glucose; Burns; Glucose; Glucose Tolerance Test; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction; Tyrosine | 2012 |
Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes.
Topics: Animals; Cell Line; Endoplasmic Reticulum Stress; Gene Knockdown Techniques; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Phosphorylation; Rats; Ribosomal Protein S6 Kinases; Sirolimus; TOR Serine-Threonine Kinases; Tyrosine | 2012 |
Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation.
Topics: Aldehydes; Animals; Body Composition; Free Radicals; Glucose Intolerance; Heart Failure; Hypertension; Insulin Resistance; Lipid Peroxidation; Liver; Male; Muscle, Skeletal; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thiazolidinediones; Tyrosine | 2012 |
Diminished muscle growth in the obese Zucker rat following overload is associated with hyperphosphorylation of AMPK and dsRNA-dependent protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; eIF-2 Kinase; Extracellular Signal-Regulated MAP Kinases; Insulin Resistance; Male; Muscle, Skeletal; Obesity; Phosphorylation; Rats; Rats, Zucker; Serine; Signal Transduction; Threonine; Tyrosine; Ubiquitination | 2012 |
Elaidyl-sulfamide, an oleoylethanolamide-modelled PPARα agonist, reduces body weight gain and plasma cholesterol in rats.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Amides; Animals; Blood Glucose; Cholesterol; Feeding Behavior; Gene Expression Profiling; Gene Expression Regulation; Glucose Tolerance Test; Humans; Hydrogen Bonding; Insulin; Insulin Resistance; Ligands; Liver; Male; Models, Molecular; Oleic Acids; Oxazoles; PPAR alpha; Protein Binding; Rats; Solutions; Sulfonamides; Taste; Thermogenesis; Tyrosine; Weight Gain | 2012 |
Genistein promotes insulin action through adenosine monophosphate-activated protein kinase activation and p70 ribosomal protein S6 kinase 1 inhibition in the skeletal muscle of mice fed a high energy diet.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Down-Regulation; Energy Intake; Fructose; Genistein; Glycine max; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred Strains; Muscle, Skeletal; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Ribosomal Protein S6 Kinases, 70-kDa; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tyrosine | 2012 |
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults.
Topics: Adult; Amino Acids; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Phenylalanine; Tyrosine; Valine; Young Adult | 2013 |
Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice.
Topics: Animals; Antioxidants; Dietary Supplements; Hyperglycemia; Hypoglycemic Agents; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Liver Glycogen; Male; Mice; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Random Allocation; Serine; Signal Transduction; Tyrosine; Xanthophylls | 2012 |
Sfrp5 correlates with insulin resistance and oxidative stress.
Topics: Adaptor Proteins, Signal Transducing; Adiponectin; Animals; Body Mass Index; Clinical Trials as Topic; Coffee; Dinoprost; Eye Proteins; Humans; Insulin; Insulin Resistance; Membrane Proteins; Mice; Middle Aged; Models, Animal; Obesity; Oxidative Stress; Proto-Oncogene Proteins; Statistics as Topic; Tyrosine; Wnt Proteins; Wnt Signaling Pathway; Wnt-5a Protein | 2013 |
Epidermal growth factor and transforming growth factor alpha mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Insulin; Insulin Resistance; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Subcellular Fractions; Transforming Growth Factor alpha; Tyrosine | 2002 |
Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells.
Topics: Animals; Cells, Cultured; Deoxyglucose; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pyridines; Receptor, Insulin; Signal Transduction; Tyrosine | 2002 |
Gliclazide increases insulin receptor tyrosine phosphorylation but not p38 phosphorylation in insulin-resistant skeletal muscle cells.
Topics: Animals; Cell Line; Deoxyglucose; Enzyme Inhibitors; Gliclazide; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Receptor, Insulin; Signal Transduction; Tyrosine | 2002 |
Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade.
Topics: Animals; Blood Glucose; Disease Models, Animal; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle Denervation; Muscle, Skeletal; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2003 |
Interleukin-6 induces cellular insulin resistance in hepatocytes.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Hepatocytes; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction; Time Factors; Tyrosine | 2002 |
Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells.
Topics: Animals; Biological Transport; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Deoxyglucose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Muscle, Skeletal; Myoblasts; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pioglitazone; Receptor, Insulin; Rosiglitazone; Thiazoles; Thiazolidinediones; Tyrosine | 2003 |
[The molecular mechanism of high glucose-induced insulin resistance in 3T3-L1 adipocytes].
Topics: 3T3 Cells; Adipocytes; Animals; Cells, Cultured; Glucose; Humans; Insulin Resistance; Mice; Phosphorylation; Protein Sorting Signals; Tyrosine | 2001 |
Tissue-specific impairment of insulin signaling in vasculature and skeletal muscle of fructose-fed rats.
Topics: Animals; Aorta, Thoracic; Dietary Sucrose; Fructose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Phosphoproteins; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Threonine; Tyrosine | 2003 |
Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold.
Topics: Animals; Blood Glucose; Cold Temperature; Eating; Fatty Acids, Nonesterified; Hormones; Hypoglycemic Agents; Hypothalamus; Immunoblotting; Injections, Intraventricular; Insulin; Insulin Resistance; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Rats; Rats, Wistar; Satiety Response; Serine; Signal Transduction; Tyrosine | 2003 |
Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation.
Topics: Adipose Tissue; Alcohol Drinking; Animals; Deoxyglucose; Enzyme Activation; Ethanol; Glucose Clamp Technique; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Tyrosine | 2003 |
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Membrane; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptor, Insulin; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tyrosine | 2003 |
High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.
Topics: Animals; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinase Signaling System; Muscle, Skeletal; Palmitic Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptor, Insulin; Serine; Sphingosine; Tyrosine | 2003 |
Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats.
Topics: Adipose Tissue; Aging; Animals; Animals, Newborn; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Sodium Glutamate; Tyrosine | 2003 |
Regulation of insulin receptor substrate-1 in the liver, skeletal muscle and adipose tissue of rats throughout pregnancy.
Topics: Adipose Tissue; Animals; Blood Glucose; Blotting, Northern; Estradiol; Female; Gene Expression; Gestational Age; Homeostasis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Pregnancy; Progesterone; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2003 |
Regulation of insulin receptor substrate-2 tyrosine phosphorylation in animal models of insulin resistance.
Topics: Animals; Dexamethasone; Disease Models, Animal; Down-Regulation; Epinephrine; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Tyrosine | 2003 |
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Adult; Animals; Biological Transport; Blotting, Northern; Cytokines; Dose-Response Relationship, Drug; Glucose; Glucose Transporter Type 4; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; Interleukin-8; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Monosaccharide Transport Proteins; Muscle Proteins; Phosphoproteins; Phosphorylation; Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Time Factors; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2003 |
Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance.
Topics: Adipocytes; Adipose Tissue; Animals; Disease Models, Animal; Fasting; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rats; Rats, Wistar; Signal Transduction; Sodium Glutamate; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
[Effects of bushen tongmai recipe on insulin signaling in insulin resistant rats].
Topics: Animals; Blood Glucose; Drugs, Chinese Herbal; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Phosphoproteins; Phosphorylation; Random Allocation; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Tyrosine | 2003 |
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.
Topics: Animals; Biological Transport; Blotting, Western; Cell Membrane; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glucose; I-kappa B Kinase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Transport; Rats; Salicylic Acid; Serine; Signal Transduction; Subcellular Fractions; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance.
Topics: Animals; Antibodies; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Glucose Clamp Technique; Hepacivirus; Hepatitis C; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Islets of Langerhans; Liver; Male; Mice; Mice, Transgenic; Phosphoproteins; Phosphorylation; Tumor Necrosis Factor-alpha; Tyrosine; Viral Core Proteins | 2004 |
Increased CD36 protein as a response to defective insulin signaling in macrophages.
Topics: Animals; Blotting, Northern; Blotting, Western; CD36 Antigens; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Foam Cells; Glutathione; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipoproteins, LDL; Macrophages; Mice; Mice, Inbred C57BL; Mice, Obese; Morpholines; Oxygen; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Signal Transduction; Thiazolidinediones; Time Factors; Transcription Factors; Transcription, Genetic; Tyrosine | 2004 |
Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Biological Transport; Blotting, Western; Body Weight; Cattle; Deoxyglucose; Diabetes Mellitus, Experimental; Glucose; Insulin; Insulin Resistance; Ligands; Ligases; Mice; Muscle, Skeletal; Muscles; Organic Chemicals; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors; Triglycerides; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
Cinnamon extract prevents the insulin resistance induced by a high-fructose diet.
Topics: Animals; Blood Glucose; Body Weight; Cinnamomum zeylanicum; Diet; Dose-Response Relationship, Drug; Eating; Fatty Acids, Nonesterified; Fructose; Glucose; Glucose Clamp Technique; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Phosphoproteins; Phosphorylation; Plant Extracts; Rats; Rats, Wistar; Receptor, Insulin; Tyrosine | 2004 |
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Topics: Animals; Fatty Acids; Genotype; Glucose; HLA Antigens; Humans; Insulin; Insulin Resistance; Isoenzymes; Male; Mice; Mice, Transgenic; Muscles; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Isoforms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; Signal Transduction; Transgenes; Tyrosine | 2004 |
[Tyrosine phosphorylation and protein expression of insulin receptor substrate-1 in the patients with polycystic ovary syndrome].
Topics: Adult; Blood Glucose; Blotting, Western; Fasting; Female; Follicle Stimulating Hormone; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Luteinizing Hormone; Phosphoproteins; Phosphorylation; Polycystic Ovary Syndrome; Tyrosine | 2004 |
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.
Topics: Animals; Blotting, Western; Cell Membrane; Cytosol; Deoxyglucose; Enzyme Activation; Fatty Acids; Fatty Liver; Glycogen; Glycogen Synthase; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Male; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Kinase C; Protein Kinase C-epsilon; Protein Transport; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Tyrosine | 2004 |
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Topics: Animals; Base Sequence; Carrier Proteins; Cells, Cultured; DNA, Complementary; Endotoxemia; Female; Gene Expression; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Phosphoproteins; Phosphorylation; Repressor Proteins; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription Factors; Tyrosine; Up-Regulation | 2004 |
Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha.
Topics: Abdomen; Acute Disease; Animals; Hemorrhage; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Serine; Tumor Necrosis Factor-alpha; Tyrosine; Wounds and Injuries | 2004 |
Infusion of beta-endorphin improves insulin resistance in fructose-fed rats.
Topics: Animals; beta-Endorphin; Diet; Fructose; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Serine; Signal Transduction; Tyrosine | 2004 |
Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats.
Topics: Adiponectin; Animals; Biomarkers; Carrier Proteins; Diabetes Mellitus; Fatty Acid-Binding Proteins; Insulin; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Lipids; Male; Obesity; Oxazoles; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Rats, Zucker; Thiazolidinediones; Tyrosine | 2004 |
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.
Topics: Adipose Tissue; Animals; Body Weight; Epididymis; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Glucose Transporter Type 4; Immunoblotting; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Serine; Signal Transduction; Subcellular Fractions; Time Factors; Tissue Distribution; Tyrosine | 2005 |
Pharmacological regulation of the insulin receptor signaling pathway mimics insulin action in cells transduced with viral vectors.
Topics: Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Dependovirus; Diabetes Mellitus, Type 1; Dimerization; Dose-Response Relationship, Drug; Fibroblasts; Gene Transfer Techniques; Genetic Vectors; Glycogen Synthase; Homozygote; Humans; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mutation; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Receptor, Insulin; Signal Transduction; Tacrolimus; Time Factors; Tyrosine | 2004 |
Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling.
Topics: Adipose Tissue; Aging; Animals; Area Under Curve; Enzyme-Linked Immunosorbent Assay; Female; Glucose; Growth Hormone; Humans; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Janus Kinase 2; Lipid Metabolism; Liver; Muscles; Obesity; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Time Factors; Tyrosine | 2005 |
Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats.
Topics: Adaptation, Physiological; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation; Glucose; In Vitro Techniques; Insulin Resistance; Male; Myocardial Contraction; Myocardium; Oxazoles; PPAR gamma; Rats; Rats, Inbred Strains; Rats, Zucker; Signal Transduction; Transcriptional Activation; Triglycerides; Tyrosine | 2005 |
[Tyrosine phosphorylation and protein expression of insulin receptor substrate-2 in the adipose tissue from patients with polycystic ovary syndrome].
Topics: Adipose Tissue; Adult; Blood Glucose; Blotting, Western; Female; Follicle Stimulating Hormone; Humans; Immunohistochemistry; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Luteinizing Hormone; Phosphoproteins; Phosphorylation; Polycystic Ovary Syndrome; Signal Transduction; Tyrosine | 2005 |
[Expression of insulin receptor substrate 1 and phosphorylation of tyrosine in adipose tissue of polycystic ovary syndrome].
Topics: Adipose Tissue; Adult; Blotting, Western; Female; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Obesity; Phosphoproteins; Phosphorylation; Polycystic Ovary Syndrome; Signal Transduction; Tyrosine | 2005 |
ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Blood Vessels; Cell Membrane; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Hypertension; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monosaccharide Transport Proteins; Muscle Proteins; Myocytes, Smooth Muscle; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine; Tyrosine | 2005 |
A biochemical and functional characterization of diet-induced brain insulin resistance.
Topics: Animals; Brain Chemistry; Cricetinae; Dietary Carbohydrates; Fructose; Hippocampus; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Mesocricetus; Neuronal Plasticity; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Tyrosine | 2005 |
Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.
Topics: Absorption; Androstadienes; Animals; Bicarbonates; Chromones; Crosses, Genetic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heterozygote; Hypoglycemic Agents; Immunoblotting; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Models, Statistical; Morpholines; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Receptor, Insulin; Tyrosine; Wortmannin | 2005 |
PPARgamma agonists diminish serum VEGF elevation in diet-induced insulin resistant SD rats and ZDF rats.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Diabetes Mellitus, Experimental; Diet; Dose-Response Relationship, Drug; Insulin; Insulin Resistance; Male; Mice; Oxazoles; PPAR gamma; Rats; Rats, Sprague-Dawley; Rats, Zucker; Tyrosine; Vascular Endothelial Growth Factor A | 2005 |
Relationships between human serum resistin, inflammatory markers and insulin resistance.
Topics: Biomarkers; Blood Glucose; Body Composition; Body Mass Index; C-Reactive Protein; Case-Control Studies; Homeostasis; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Regression Analysis; Resistin; Triglycerides; Tyrosine; Uric Acid | 2005 |
Organo-vanadium compounds are potent activators of the protein kinase B signaling pathway and protein tyrosine phosphorylation: mechanism of insulinomimesis.
Topics: Animals; Blood Glucose; Cells, Cultured; CHO Cells; Cricetinae; Diabetes Mellitus; Glycogen Synthase Kinase 3; Hypoglycemic Agents; Insulin; Insulin Resistance; Organometallic Compounds; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine; Vanadium Compounds | 2005 |
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.
Topics: Adipocytes; Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Middle Aged; Okadaic Acid; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Time Factors; Tyrosine | 2005 |
Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-1; Interleukin-6; Mice; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Tyrosine | 2006 |
The vanadyl (VO2+) chelate bis(acetylacetonato)oxovanadium(IV) potentiates tyrosine phosphorylation of the insulin receptor.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Chelating Agents; Enzyme Activation; Glycogen; Glycogen Synthase; Hypoglycemic Agents; Insulin Resistance; Mice; Molecular Structure; Organometallic Compounds; Phosphorylation; Pyrones; Receptor, Insulin; Solutions; Tyrosine; Vanadates | 2005 |
Increased collagen content in insulin-resistant skeletal muscle.
Topics: Adult; Biopsy; Collagen Type I; Collagen Type III; Diabetes Mellitus, Type 2; Extracellular Matrix; Female; Glucose; Humans; Hydroxyproline; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Microscopy, Fluorescence; Middle Aged; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Tyrosine | 2006 |
Impaired generation of reactive oxygen species in leprechaunism through downregulation of Nox4.
Topics: Abnormalities, Multiple; Cells, Cultured; Down-Regulation; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Insulin Resistance; NADPH Oxidase 4; NADPH Oxidases; Phenotype; Phosphorylation; Platelet-Derived Growth Factor; Reactive Oxygen Species; Tyrosine | 2005 |
Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
Topics: Adiponectin; Animals; Dietary Fats; Dietary Sucrose; Dose-Response Relationship, Drug; Insulin Resistance; Male; Muscle, Skeletal; Oxazoles; PPAR gamma; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Down-Regulation; Insulin; Insulin Resistance; Mice; Mice, Inbred BALB C; Mice, Obese; Muscle, Skeletal; Myocardium; Obesity; Phosphorylation; Proto-Oncogene Proteins c-cbl; rho GTP-Binding Proteins; Signal Transduction; Tyrosine | 2006 |
A novel dual peroxisome proliferator-activated receptors alpha and gamma agonist with beneficial effects on insulin resistance and lipid metabolism.
Topics: Adipocytes; Adipogenesis; Animals; Cell Differentiation; Diabetes Complications; Humans; Insulin Resistance; Lipid Metabolism; Male; Mice; Models, Animal; Oxazoles; PPAR alpha; PPAR gamma; Tyrosine; Up-Regulation | 2006 |
gamma-tocopherol, but not alpha-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats.
Topics: Acridines; alpha-Tocopherol; Animals; Antioxidants; Blood Pressure; gamma-Tocopherol; Insulin; Insulin Resistance; Male; Muscle, Smooth, Vascular; Oxidative Stress; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Tunica Intima; Tyrosine; Vascular Diseases; Vitamin E | 2006 |
The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats.
Topics: Adipose Tissue; Animals; Animals, Genetically Modified; Female; Glucose; Glycogen; Glycogen Synthase; Hepatocytes; Human Growth Hormone; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Lipid Metabolism; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Rats; Receptor, Insulin; RNA, Messenger; Tyrosine | 2006 |
Catalytically inactive lipoprotein lipase overexpression increases insulin sensitivity in mice.
Topics: Animals; Animals, Genetically Modified; Cells, Cultured; CHO Cells; Cricetinae; Dietary Fats; Glucose; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipoprotein Lipase; Mice; Mice, Inbred ICR; Mice, Nude; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Triglycerides; Tyrosine | 2006 |
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; GTPase-Activating Proteins; Inflammation; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-1beta; Interleukin-6; MAP Kinase Signaling System; Mice; Mice, Obese; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Tyrosine | 2007 |
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
Topics: Aging; Animals; Animals, Newborn; Cell Line, Transformed; Down-Regulation; Gene Expression; Gene Expression Profiling; Gene Transfer Techniques; Gluconeogenesis; Hepatocytes; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrosine; Up-Regulation | 2007 |
Subcutaneous fat modulates insulin sensitivity in mice by regulating TNF-alpha expression in visceral fat.
Topics: Animals; Epididymis; Gene Expression; Glucose Tolerance Test; Insulin Receptor Substrate Proteins; Insulin Resistance; Intra-Abdominal Fat; Lipectomy; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Subcutaneous Fat; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Oxidative stress in the metabolic syndrome.
Topics: Adult; Blood Glucose; Blood Pressure; Brachial Artery; Case-Control Studies; Female; Humans; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Oxidative Stress; Regional Blood Flow; Tyrosine; Vasodilation | 2006 |
Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein.
Topics: Animals; Autoantigens; Hepacivirus; Hepatitis C; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Protein v-akt; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, Insulin; Tyrosine; Viral Core Proteins | 2007 |
[Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats].
Topics: Adaptor Proteins, Signal Transducing; Animals; Blood Glucose; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Serine; Tyrosine | 2006 |
Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Diabetes Mellitus; Dietary Fats; Epididymis; Gene Expression Regulation; Hypoglycemic Agents; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Pioglitazone; PPAR gamma; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiazolidinediones; Tyrosine | 2007 |
Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Gluconeogenesis; Hepatocytes; Hypoglycemic Agents; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Oleic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tyrosine | 2007 |
[Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn].
Topics: Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Burns; Dimethyl Sulfoxide; Disease Models, Animal; Female; Glucose Clamp Technique; Immunohistochemistry; Injections, Intravenous; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Muscles; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Serine; Tyrosine | 2007 |
[Relationship between tyrosine phosphorylation and protein expression of insulin receptor substrate-1 and insulin resistance in gestational diabetes mellitus].
Topics: Adult; Blood Glucose; Blotting, Western; Body Mass Index; Diabetes, Gestational; Fasting; Female; Gestational Age; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Pregnancy; Tyrosine | 2007 |
Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake.
Topics: Adipokines; Analysis of Variance; Biomarkers; Carrier Proteins; Case-Control Studies; Fatty Liver; Feeding Behavior; Female; Humans; Insulin Resistance; Liver; Male; Metabolic Syndrome; Middle Aged; Oxidative Stress; Polymorphism, Genetic; Risk Factors; Severity of Illness Index; Tyrosine; Vitamin A | 2007 |
Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB.
Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Animals; Biological Transport; Blotting, Western; Dietary Fats; Ginsenosides; Glucose; Glucose Transporter Type 4; Hyperglycemia; Immunoprecipitation; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Mice; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Rats, Wistar; Tyrosine | 2008 |
Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Body Weight; Cholesterol; Diet; Dietary Fats; Dietary Supplements; Glucose Tolerance Test; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Momordica charantia; Muscle Proteins; Muscle, Skeletal; Phosphorylation; Rats; Rats, Wistar; Triglycerides; Tyrosine | 2008 |
Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.
Topics: Animals; Drug Combinations; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Female; Glucose; Glucose Clamp Technique; Glycerol; I-kappa B Kinase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serine; Signal Transduction; Sodium Salicylate; Time Factors; Tyrosine | 2007 |
Nitric oxide bioavailability and not production is first altered during the onset of insulin resistance in sucrose-fed rats.
Topics: Animals; Aorta; Biomarkers; Cyclic GMP; Cysteine; Diet; Diet Therapy; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Insulin Resistance; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Sucrose; Sweetening Agents; Tyrosine | 2007 |
Defect in phosphorylation of insulin receptors in cells from an insulin-resistant patient with normal insulin binding.
Topics: Caseins; Female; Glutamates; Glutamic Acid; Humans; Insulin; Insulin Resistance; Monocytes; Phosphorylation; Protein Kinases; Receptor, Insulin; Syndrome; Tyrosine | 1984 |
[Effect of insulin on amino acid transport and protein synthesis in the skeletal muscle of the normal mouse and the insulin-resistant mouse].
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Insulin; Insulin Resistance; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscles; Obesity; Tyrosine | 1983 |
Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Fibroblasts; Glucose; Humans; Hypoglycemic Agents; Immunoblotting; Immunosorbent Techniques; Insulin Resistance; Isoquinolines; Kinetics; Phosphorylation; Phosphotyrosine; Piperazines; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 1994 |
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Immunoglobulin G; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Muscles; Neutralization Tests; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor, Insulin; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Rescue and activation of a binding-deficient insulin receptor. Evidence for intermolecular transphosphorylation.
Topics: 3T3 Cells; Animals; Enzyme Activation; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptor, Insulin; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Topics: Animals; Blood Glucose; Female; Growth; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tyrosine | 1994 |
Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Blotting, Western; Cell Line; Cytosol; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Kinetics; Macromolecular Substances; Phosphotyrosine; Pioglitazone; Protein Tyrosine Phosphatases; Raffinose; Rats; Receptor, Insulin; Recombinant Proteins; Swine; Thiazoles; Thiazolidinediones; Transfection; Tyrosine | 1995 |
Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Division; CHO Cells; Cricetinae; Drosophila; Enzyme Activation; GTPase-Activating Proteins; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Isoenzymes; Kinetics; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1.
Topics: Alkaloids; Animals; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance.
Topics: Adolescent; Adult; Blood Glucose; Cells, Cultured; Fasting; Female; Fibroblasts; Food; Humans; Immunosorbent Techniques; Insulin; Insulin Resistance; Male; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1993 |
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Macromolecular Substances; Mice; Mice, Obese; Muscles; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Tyrosine | 1993 |
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Biological Transport, Active; Calcium-Calmodulin-Dependent Protein Kinases; Glucose; GRB2 Adaptor Protein; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Mice; Mice, Knockout; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Proteins; Receptor, Insulin; Ribosomal Protein S6 Kinases; Transcription Factors; Tyrosine | 1996 |
Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.
Topics: 3T3 Cells; Adipose Tissue; Animals; Glucose; Glucose Transporter Type 4; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphoproteins; Phosphorylation; Protein Kinases; Receptor, Insulin; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
Topics: Animals; Binding Sites; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rats; Receptor, Insulin; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats.
Topics: Albumins; Amino Acid Sequence; Animals; Base Sequence; Blood Glucose; Down-Regulation; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Molecular Sequence Data; Muscle, Skeletal; Myosins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Zucker; RNA, Messenger; Signal Transduction; Tyrosine | 1998 |
Nutritional state regulates insulin receptor and IRS-1 phosphorylation and expression in chicken.
Topics: Animals; Blood Glucose; Chickens; Eating; Fasting; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Mice; Muscles; Phosphoproteins; Phosphorylation; Receptor, Insulin; RNA, Messenger; Tyrosine | 1998 |
An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-alpha.
Topics: Animals; Blood Physiological Phenomena; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Liver; Mice; Obesity; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Rats, Zucker; Receptor, Insulin; Reference Values; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 1998 |
Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.
Topics: Adipose Tissue; Animals; Dietary Fats; Enzyme Activation; Epididymis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscles; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Tyrosine | 1999 |
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Topics: Animals; Deoxyglucose; Enzyme Activation; Fatty Acids, Nonesterified; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-theta; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine; Zinc Fingers | 1999 |
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.
Topics: Animals; Enzyme Activation; Glucosamine; Glycosylation; Hexosamines; Insulin; Insulin Resistance; Lipid Metabolism; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Protein Isoforms; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Tyrosine | 1999 |
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Microcirculation; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Zucker; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Tyrosine | 1999 |
Glucosamine-induced insulin resistance in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Membrane; Deoxyglucose; Dose-Response Relationship, Drug; Glucosamine; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Ribosomal Protein S6 Kinases; Tyrosine | 2000 |
Clinical characteristics of type 2 diabetes in patients with mutations of HFE.
Topics: Amino Acid Substitution; Aspartic Acid; Cysteine; Diabetes Mellitus, Type 2; Female; Ferritins; Hemochromatosis Protein; Heterozygote; Histidine; Histocompatibility Antigens Class I; HLA Antigens; Humans; Insulin Resistance; Iron; Major Histocompatibility Complex; Male; Membrane Proteins; Middle Aged; Point Mutation; Transferrin; Tyrosine | 2000 |
Protein kinase C modulates insulin action in human skeletal muscle.
Topics: Abdominal Muscles; Adult; Biological Transport; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Glucose; Humans; Indoles; Insulin; Insulin Resistance; Maleimides; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Receptor, Insulin; Reference Values; Tyrosine | 2000 |
Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.
Topics: Adult; Base Sequence; Cell Line; Fasting; Female; Genetic Variation; Humans; Insulin; Insulin Resistance; Male; Pedigree; Phosphatidylinositol 3-Kinases; Phosphorylation; Polymorphism, Genetic; Signal Transduction; Tyrosine | 2000 |
Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4.
Topics: Adipocytes; Aging; Animals; Electrophoresis, Polyacrylamide Gel; Glucose; Glucose Transporter Type 4; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Monosaccharide Transport Proteins; Muscle Proteins; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; Signal Transduction; Tyrosine; Vanadates | 2000 |
Development and comparison of two 3T3-L1 adipocyte models of insulin resistance: increased glucose flux vs glucosamine treatment.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Biological Transport; Glucosamine; Glucose; Glucose Transporter Type 4; Insulin; Insulin Resistance; Kinetics; Mice; Models, Biological; Molecular Sequence Data; Monosaccharide Transport Proteins; Muscle Proteins; N-Acetylglucosaminyltransferases; Platelet-Derived Growth Factor; Signal Transduction; Transaminases; Tyrosine | 2000 |
Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.
Topics: Animals; CSK Tyrosine-Protein Kinase; Down-Regulation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Insulin; Insulin Resistance; Liver; Obesity; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptor, Insulin; Receptors, Cell Surface; Recombinant Proteins; src-Family Kinases; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.
Topics: Animals; Arteriosclerosis; Base Sequence; CD36 Antigens; DNA Primers; Female; Gene Expression; Humans; Insulin Resistance; Ligands; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, LDL; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Rosiglitazone; Scavenger Receptors, Class B; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Regulation of cardiac Jak-2 in animal models of insulin resistance.
Topics: Animals; Dexamethasone; DNA-Binding Proteins; Enzyme Activation; Epinephrine; Fasting; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Male; Myocardium; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Wistar; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Immobilization depresses insulin signaling in skeletal muscle.
Topics: Animals; Atrophy; Glucose; Hypoglycemic Agents; Immobilization; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Organ Size; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Tyrosine | 2000 |
Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes.
Topics: Adipocytes; Animals; Deoxyglucose; Hyperglycemia; Immunoblotting; Insulin Resistance; Male; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Tyrosine | 2001 |
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
Topics: Animals; Anisomycin; CHO Cells; Cricetinae; Insulin; Insulin Antagonists; Insulin Resistance; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Insulin; Serine; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Deoxyglucose; Diet, Sodium-Restricted; Enzyme Activation; Glucose Clamp Technique; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Thiazoles; Thiazolidinediones; Tyrosine | 2001 |
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Topics: Amino Acid Sequence; Cell Line; Chromatography, Liquid; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins; Tyrosine | 2001 |
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells.
Topics: Amino Acids; Biological Transport; Cell Line; Enzyme Activation; Feedback; Glucose; Hydrolysis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Tyrosine | 2001 |
Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.
Topics: Animals; Blotting, Western; Gene Deletion; Humans; Insulin; Insulin Resistance; Phosphorylation; Rats; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine | 2001 |
Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.
Topics: Animals; CD36 Antigens; Chromans; Emulsions; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Glucose; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lecithins; Ligands; Liver; Male; Membrane Glycoproteins; Muscle, Skeletal; Organic Anion Transporters; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Safflower Oil; Soybean Oil; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tyrosine | 2001 |
Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle.
Topics: Adult; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Lipolysis; Male; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptor, Insulin; Signal Transduction; Tyrosine | 2001 |
Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Medical Records; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Receptor, Insulin; Signal Transduction; Tyrosine | 2001 |
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity.
Topics: Adipocytes; Amino Acids; Animals; Binding Sites; Blood Glucose; Body Weight; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Fluorenes; Gene Expression Regulation; Genes, Reporter; Hypoglycemic Agents; Insulin Resistance; Leucine; Ligands; Male; Mice; Mice, Inbred Strains; Molecular Structure; Protein Binding; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Tyrosine | 2001 |
Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance.
Topics: Animals; Glucose Clamp Technique; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Isoenzymes; Liver; Male; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Sucrose; Tyrosine | 2002 |
Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins.
Topics: Anisomycin; Cycloheximide; Genes, erbB; Genes, erbB-2; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoproteins; Serine; Threonine; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Acetylglucosamine; Adipocytes; Animals; beta Catenin; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Cell Line; Cell Nucleus; Cytoplasm; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Glucosamine; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Glycosylation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; Trans-Activators; Tyrosine | 2002 |
Amino acid- and lipid-induced insulin resistance in rat heart: molecular mechanisms.
Topics: Amino Acids; Animals; Biological Transport; Glucose; Glycogen Synthase Kinase 3; Heart; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Metabolism; Mitogen-Activated Protein Kinases; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Threonine; Tyrosine | 2002 |
Troglitazone inhibits growth and improves insulin signaling by suppression of angiotensin II action in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Arteriosclerosis; Cell Division; Cells, Cultured; Chromans; Depression, Chemical; DNA; Growth Substances; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 2002 |
High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats.
Topics: Adipose Tissue; Animals; Deoxyglucose; Enzyme Activation; Humans; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Potassium, Dietary; Rats; Rats, Inbred Dahl; Signal Transduction; Sodium Chloride, Dietary; Species Specificity; Tyrosine | 2002 |
Defects of insulin's signal transduction in old rat livers.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Female; Glucose; Immunoblotting; Injections, Intravenous; Insulin; Insulin Resistance; Liver; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Signal Transduction; Time Factors; Tyrosine | 1992 |
High-fat feeding induces tissue-specific alteration in proportion of activated insulin receptors in rats.
Topics: Animals; Cell Membrane; Dietary Fats; Insulin; Insulin Resistance; Kidney; Liver; Male; Muscles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1990 |
Tyrosine-kinase defect of the insulin receptor in cultured fibroblasts from patients with lipoatropic diabetes.
Topics: Adolescent; Adult; Autoradiography; Binding Sites; Binding, Competitive; Cells, Cultured; Child; Child, Preschool; Chromatography, Affinity; Diabetes Mellitus, Lipoatrophic; Female; Humans; Infant; Insulin Resistance; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Serine; Tyrosine | 1989 |
Insulin receptor kinase defects as a possible cause of cellular insulin resistance.
Topics: Adipose Tissue; Animals; Catecholamines; Cell Line; Cell Membrane; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Melanoma, Experimental; Mice; Muscles; Phorbol Esters; Phosphorylation; Phosphotransferases; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor, Insulin; Tyrosine | 1987 |
Plasma amino acid levels and insulin secretion in obesity.
Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Middle Aged; Obesity; Pancreas; Phenylalanine; Tyrosine; Valine | 1969 |