tyrosine has been researched along with Granulocytic Leukemia, Chronic in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.39) | 18.7374 |
| 1990's | 23 (31.94) | 18.2507 |
| 2000's | 28 (38.89) | 29.6817 |
| 2010's | 13 (18.06) | 24.3611 |
| 2020's | 7 (9.72) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, YJ; Rao, GW; Xu, XL; Zhang, W | 1 |
| Conte, C; Despas, F; Gauthier, M; Herin, F; Huguet, F; Mestre, ML; Pajiep, MC; Vayr, F | 1 |
| Doytchinova, I; Iwanov, I; Momekov, G; Montesi, M; Naydenova, E; Panseri, S; Rossi, A; Sargsyan, A | 1 |
| Cao, J; Chen, F; Chen, Y; Feng, XH; Gao, C; Gu, S; Li, X; Liang, T; Lin, X; Liu, X; Qin, J; Tong, H; Wang, L; Xu, P; Yu, Y; Yuan, S; Zhao, B | 1 |
| Abramson, MH; Adegbite, BO; Azeloglu, EU; Berman, EM; Campbell, KN; Chan, L; Chauhan, K; Coca, SG; El Ghaity-Beckley, S; Gutgarts, V; Jaimes, EA; Kremyanskaya, M; Marcellino, B; Mascarenhas, JO; Meliambro, KA; Musteata, FM; Muwonge, AN; Salvatore, SP | 1 |
| Gotoh, A; Okabe, S | 1 |
| Hori, T; Moriyama, K | 1 |
| Carraro, MC; Castelli, R; Gidaro, A; Rossi, RS; Salvi, E | 1 |
| Annamaneni, S; Battini, MR; Digumarti, RR; Gorre, M; Kagita, S; Satti, V | 1 |
| Bu, Q; Cui, L; Ding, K; Du, X; Li, J; Pan, J; Zou, W | 1 |
| Aspinall-O'Dea, M; Holyoake, TL; Pellicano, F; Pierce, A; Scott, MT; Walker, MJ; Whetton, AD; Williamson, AJ | 1 |
| Aslan, JE; Druker, BJ; Gruber, A; Healy, LD; Loren, CP; McCarty, OJ; Nowak, MS; Rigg, RA | 1 |
| Cao, W; Feng, W; Gao, M; Huang, Z; Li, Q; Luo, H; Xiao, Q | 1 |
| Alhashimi, F; Hamilton, A; Holyoake, TL; Jorgensen, HG; Myssina, S | 1 |
| Arlinghaus, R; Bhatia, R; Chakraborty, S; Modi, H; Perazzona, B; Priebe, W; Samanta, A; Sun, X | 1 |
| Birge, RB; Ge, Q; Hornbeck, P; Kalodimos, CG; Kaushal, N; Li, J; Machida, K; Mayer, B; Reichman, C; Saleh, T; Sriram, G; Tunceroglu, A | 1 |
| Dasgupta, Y; Donlin, M; Fleury, F; Gurdek, E; Nieborowska-Skorska, M; Ren, SY; Skorski, T; Slupianek, A | 1 |
| Cao, WX; Deng, JR; Feng, WL; Li, YJ; Luo, HW; Peng, Z; Shi, J; Wang, HX; Yuan, Y | 1 |
| Chen, JL; Chen, K; Druker, BJ; Guo, G; Kashiwada, M; Qiu, X; Rothman, PB | 1 |
| Anderson, KI; Bleijerveld, OB; Corradini, E; Heck, AJ; Kolch, W; Müller, PJ; Preisinger, C; Scholten, A; Schwarz, JP | 1 |
| Fujioka, Y; Nakada, S; Ohba, Y; Tsuda, M | 1 |
| Dello Sbarba, P; Desplat, V; Faucher, JL; Ivanovic, Z; Mahon, FX; Praloran, V | 1 |
| Brasher, BB; Gorre, ME; Nicoll, J; Roumiantsev, S; Sawyers, CL; Shah, NP; Van Etten, RA | 1 |
| Bhalla, KN; Cunnick, JM; Dorsey, JF; Huang, M; Jove, R; Kraker, AJ; Lanehart, R; Wu, J | 1 |
| Hochhaus, A; Lahaye, T; Müller, MC | 1 |
| Arlinghaus, RB | 1 |
| Breitenbuecher, F; Carius, B; Fischer, T; Gschaidmeier, H; Huber, C; Kasper, S; Kindler, T; Stevens, T | 1 |
| Banger, N; Berdel, WE; Chou, TC; Kiehl, M; Koch, OM; Müller-Tidow, C; Probst, M; Serve, H; Sindermann, JR; Zühlsdorf, M | 1 |
| Akiyama, S; Aoki, S; Che, XF; Furukawa, T; Haraguchi, M; Kobayashi, M; Mukai, M; Ren, XQ; Sugimoto, Y; Sumizawa, T; Takamatsu, H | 1 |
| Smith, KM; Van Etten, RA; Yacobi, R | 1 |
| Bohr, VA; Cheng, WH; Fields, KM; Kufe, D; Opresko, PL; Ren, J; von Kobbe, C | 1 |
| Bai, RY; Duyster, J; Grundler, R; Hoepfl, J; Miething, C; Mugler, C; Peschel, C | 1 |
| Ishida, T; Kamano, H; Kitanaka, A; Kubota, Y; Ohnishi, H; Okutani, Y; Taminato, T; Tanaka, T | 1 |
| Babendreier, E; Chauhan, D; Chu, SC; Gramlich, JL; Griffin, JD; Kim, JH; Podar, K; Pride, YB; Salgia, R; Sattler, M | 1 |
| Cortes, JE; Donato, NJ; Gao, H; Kantarjian, HM; Lee, BN; Reuben, JM; Talpaz, M | 1 |
| Kim, S; Kim, Y; Lee, D; Oh, C; Park, J; Yoon, SS | 1 |
| Basic, I; Chandra, J; Giles, F; Golemovic, M; Kantarjian, H; Manshouri, T; Orsolic, N; Quintás-Cardama, A; Scappini, B; Verstovsek, S | 1 |
| Clarkson, B; Hajivandi, M; Liang, X; Pope, RM; Resh, MD; Veach, D; Wisniewski, D | 1 |
| Benati, D; Bustos, VH; Coluccia, AM; Duñach, M; Gambacorti-Passerini, C; Mologni, L; Pinna, LA; Redaelli, S; Vacca, A | 1 |
| Cougoule, C; Daubon, T; Le Cabec, V; Maridonneau-Parini, I; Poincloux, R | 1 |
| Bhatia, R; Chu, S; Li, L; Singh, H | 1 |
| Apperley, JF; Davis, HP; de Lavallade, H; Goldman, JM; Kaeda, JS; Khorashad, JS; Marin, D; Milojkovic, D | 1 |
| Bumm, T; Deininger, MW; Druker, BJ; Hantschel, O; Kaupe, I; Press, RD; Sherbenou, DW; Superti-Furga, G; Turaga, L; Willis, S | 1 |
| Chen, LB; de Jong, R; Druker, B; Heisterkamp, N; Li, JL; Okuda, K; Pisick, E; Salgia, R; Sattler, M; Uemura, N | 1 |
| Clark, JW; Frackelton, AR; Kannan, B; Kumar, PS | 1 |
| Anafi, M; Ben-Neriah, Y; Gazit, A; Levitzki, A; Zehavi, A | 1 |
| Fujita, J; Maruyama, Y; Ogawa, K; Okuma, M; Sawada, H; Sawai, H; Tashima, M; Toi, T | 1 |
| Goodwyn, D; Itaya, T; Kawamura, K; Miyagishima, T; Miyazaki, T; Okabe, M; Sakurada, K; Shoji, M; Uehara, M; Vogler, WR | 1 |
| Arlinghaus, RB; Groffen, J; Guo, JQ; Heisterkamp, N; ten Hoeve, J | 1 |
| Golde, DW; Lacomis, L; Nichols, GL; Raines, MA; Tempst, P; Vera, JC | 1 |
| Harrison-Findik, D; Susa, M; Varticovski, L | 1 |
| Fujii, T; Hirai, H; Honda, H; Mano, H; Takatoku, M; Witte, ON; Yazaki, Y | 1 |
| Bergan, RC; Connell, Y; Kyle, E; Neckers, L | 1 |
| Bühring, HJ; Busch, FW; Handgretinger, R; Jallal, B; Ludwig, WD; Sures, I; Ullrich, A; Waller, HD; Weiss, FU | 1 |
| de Jong, R; Groffen, J; Heisterkamp, N; ten Hoeve, J | 1 |
| Brunkhorst, B; Chen, LB; Griffin, JD; Li, JL; Lo, SH; Pisick, E; Salgia, R | 1 |
| Druker, BJ; Griffin, JD; Hagopian, JR; Heaney, C; Oda, T; Okuda, K | 1 |
| Hayashi, Y; Hino, K; Honma, Y; Hozumi, M; Matsuo, Y; Omura, S; Sato, S; Shibata, K; Tomoyasu, S; Tsuruoka, N | 1 |
| Kuwao, F; Takahashi, I | 1 |
| Arlinghaus, RB; Laneuville, P; Liu, J; Wilson-Rawls, J; Xie, S | 1 |
| Danhauser-Riedl, S; Druker, BJ; Emmerich, B; Hallek, M; Warmuth, M | 1 |
| Burl, S; Chahine, H; Damen, J; Eaves, A; Eaves, C; Krystal, G; Liu, L; Maguer-Satta, V | 1 |
| Million, RP; Van Etten, RA | 1 |
| Arlinghaus, RB; Champlin, R; Estrov, Z; Guo, JQ; Hawk, N; Lin, H; Lin, SH; Liu, J; Luo, W; Sun, T; Talpaz, M; Wang, Y; Wu, Y | 1 |
| Arlinghaus, RB; Belmont, J; Lin, F; Lin, H; Liu, J; Monaco, G; Stephens, C; Sun, T | 1 |
| Fujita, S; Narumi, H; Sakai, I; Soga, S; Takeuchi, K; Yamauchi, H | 1 |
| Choi, JK; He, Y; Karnell, FG; Miller, JP; Pear, WS; Ren, R; Wertheim, JA; Xu, L | 1 |
| Andersson, LC; Autero, M; Mustelin, T; Oetken, C; Ruutu, T; von Willebrand, M | 1 |
| Dizdaroglu, M; Nackerdien, Z; Olinski, R | 1 |
| Hirata, J; Nawata, H; Nishimura, J; Okamura, J; Sadamura, S; Shibata, K; Takahira, H; Umemura, T | 1 |
| Druker, B; Griffin, JD; Matulonis, U; Okuda, K; Roberts, T; Salgia, R | 1 |
| Nawata, H; Nishimura, J; Shibata, K; Takahira, H | 1 |
3 review(s) available for tyrosine and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Research Status, Synthesis and Clinical Application of Recently Marketed and Clinical BCR-ABL Inhibitors.
Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Protein Kinase Inhibitors; Tyrosine | 2022 |
Fluorescent protein-based biosensors and their clinical applications.
Topics: Animals; Antineoplastic Agents; Biosensing Techniques; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Green Fluorescent Proteins; Humans; Ions; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Models, Molecular; Spectrometry, Fluorescence; Tyrosine | 2013 |
Bcr: a negative regulator of the Bcr-Abl oncoprotein in leukemia.
Topics: Amino Acid Sequence; Animals; Fusion Proteins, bcr-abl; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Oncogene Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Tyrosine | 2002 |
69 other study(ies) available for tyrosine and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Impact of the treatment of chronic myeloid leukaemia by tyrosine-kinase inhibitors on sick leaves refund: a nationwide cohort study.
Topics: Adolescent; Adult; Case-Control Studies; Cohort Studies; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Protein Kinase Inhibitors; Sick Leave; Tyrosine; Young Adult | 2022 |
Peptide-based targeted cancer therapeutics: Design, synthesis and biological evaluation.
Topics: Antineoplastic Agents; Glioblastoma; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Peptides; Protein Kinase Inhibitors; Tyrosine | 2022 |
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia.
Topics: Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Smad4 Protein; Transforming Growth Factor beta; Tyrosine | 2023 |
Patient-Specific Pharmacokinetics and Dasatinib Nephrotoxicity.
Topics: Albuminuria; Dasatinib; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Proteinuria; Tyrosine | 2023 |
Effect of asciminib and vitamin K2 on Abelson tyrosine-kinase-inhibitor-resistant chronic myelogenous leukemia cells.
Topics: Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Protein Kinase Inhibitors; Tyrosine; Vitamin K 2; Vitamin K Epoxide Reductases | 2023 |
BCR-ABL induces tyrosine phosphorylation of YAP leading to expression of Survivin and Cyclin D1 in chronic myeloid leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Protein Kinase Inhibitors; src-Family Kinases; Survivin; Transcription Factors; Tyrosine; YAP-Signaling Proteins | 2019 |
Concomitant use of Tyrosine-Kinase Inhibitor and Mepolizumab in Asthma Secondary to Chronic Myeloid Leukemia with Hypereosinophilia.
Topics: Anti-Asthmatic Agents; Antibodies, Monoclonal, Humanized; Asthma; Eosinophils; Female; Humans; Hypereosinophilic Syndrome; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Protein Kinase Inhibitors; Treatment Outcome; Tyrosine | 2021 |
Incidence of internal tandem duplications and D835 mutations of FLT3 gene in chronic myeloid leukemia patients from Southern India.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Base Sequence; Child; DNA Mutational Analysis; Female; fms-Like Tyrosine Kinase 3; Gene Duplication; Gene Frequency; Humans; India; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Tandem Repeat Sequences; Tyrosine; Young Adult | 2014 |
SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydroxamic Acids; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Tyrosine; Vorinostat | 2014 |
Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.
Topics: Adaptor Proteins, Signal Transducing; Antibodies; Blotting, Western; Flow Cytometry; Fusion Proteins, bcr-abl; High-Throughput Screening Assays; Isoelectric Focusing; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocyte Common Antigens; Nuclear Proteins; Phosphorylation; Proteins; Stem Cells; Tyrosine | 2015 |
The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear.
Topics: Amino Acid Motifs; Apoptosis; Blood Platelets; Collagen; Endothelial Cells; Fibrinogen; Fusion Proteins, bcr-abl; Humans; Imidazoles; Immunoreceptor Tyrosine-Based Activation Motif; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; P-Selectin; Phosphatidylserines; Phosphorylation; Platelet Activation; Platelet Aggregation; Pyridazines; Shear Strength; Signal Transduction; Tyrosine | 2015 |
Blockade of Y177 and Nuclear Translocation of Bcr-Abl Inhibits Proliferation and Promotes Apoptosis in Chronic Myeloid Leukemia Cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Signaling System; Nuclear Localization Signals; Protein Transport; Sirolimus; STAT5 Transcription Factor; Tyrosine | 2017 |
Optimization of methods for the detection of BCR-ABL activity in Philadelphia-positive cells.
Topics: Enzyme-Linked Immunosorbent Assay; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methods; Phosphorylation; Research Design; Tyrosine | 2009 |
Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Female; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Janus Kinase 2; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyrimidines; Signal Transduction; STAT5 Transcription Factor; Sulfonamides; Tyrosine | 2011 |
Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation.
Topics: Cell Line, Tumor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Phosphorylation; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-crk; src Homology Domains; Transcriptional Activation; Tyrosine | 2011 |
Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia.
Topics: Animals; Blotting, Western; Cell Line, Tumor; DNA Repair; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Polymerase Chain Reaction; Rad51 Recombinase; Transfection; Tyrosine | 2011 |
Targeting BCR tyrosine177 site with novel SH2-DED causes selective leukemia cell death in vitro and in vivo.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line, Tumor; Female; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Mice, Nude; Repressor Proteins; src Homology Domains; Tyrosine | 2012 |
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Elongin; Female; Fusion Proteins, bcr-abl; Gene Expression; Humans; Janus Kinase 1; Janus Kinase 2; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Nude; Mutation; Phosphorylation; Protein Binding; Signal Transduction; STAT Transcription Factors; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription Factors; Tyrosine | 2012 |
Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Benzamides; Blast Crisis; Cell Membrane; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Phosphotyrosine; Piperazines; Pyrimidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tyrosine | 2013 |
Hypoxia modifies proliferation and differentiation of CD34(+) CML cells.
Topics: Antigens, CD34; Cell Differentiation; Cell Division; Cell Hypoxia; Cell Membrane; Cell Survival; Down-Regulation; Gene Expression; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplastic Stem Cells; Phosphorylation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tumor Cells, Cultured; Tyrosine | 2002 |
Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop.
Topics: Antineoplastic Agents; Benzamides; Drug Resistance; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phenylalanine; Phosphorylation; Piperazines; Point Mutation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyrimidines; Tyrosine | 2002 |
Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors.
Topics: Annexin A5; Apoptosis; Cell Line, Transformed; Enzyme Inhibitors; Flow Cytometry; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Interleukin-3; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Tyrosine | 2002 |
[Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells].
Topics: Amino Acid Substitution; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Clone Cells; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Histidine; Humans; Hydroxyurea; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mercaptopurine; Middle Aged; Oncogene Proteins, Fusion; Piperazines; Point Mutation; Pyrimidines; Selection, Genetic; Tyrosine | 2002 |
In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Caspases; Cell Division; Cytarabine; DNA; DNA-Binding Proteins; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; In Situ Nick-End Labeling; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Milk Proteins; Phosphorylation; Piperazines; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein-Tyrosine Kinases; Pyrimidines; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine; U937 Cells | 2003 |
Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon alpha-2; Interferon-alpha; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lovastatin; Mevalonic Acid; Phosphorylation; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Serine; Threonine; Time Factors; Tyrosine | 2003 |
Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Membrane; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; KB Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukotrienes; Multidrug Resistance-Associated Proteins; Phosphorylation; Photoaffinity Labels; Piperazines; Pyrimidines; Tyrosine | 2003 |
Autoinhibition of Bcr-Abl through its SH3 domain.
Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cell Transformation, Neoplastic; Enzyme Inhibitors; Eukaryotic Cells; Feedback, Physiological; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Models, Molecular; Mutation; Phosphorylation; Proline; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Tyrosine | 2003 |
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.
Topics: Animals; Benzamides; Binding Sites; Bleomycin; DNA Damage; DNA Helicases; Enzyme Inhibitors; Exodeoxyribonucleases; HeLa Cells; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Phosphorylation; Piperazines; Protein Transport; Proto-Oncogene Proteins c-abl; Pyrimidines; Recombinant Proteins; RecQ Helicases; Signal Transduction; src Homology Domains; Tumor Cells, Cultured; Tyrosine; Werner Syndrome Helicase | 2003 |
Phosphorylation of tyrosine 393 in the kinase domain of Bcr-Abl influences the sensitivity towards imatinib in vivo.
Topics: Antineoplastic Agents; Benzamides; Cell Division; Cell Line; DNA-Binding Proteins; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Milk Proteins; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Piperazines; Pyrimidines; STAT5 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 2003 |
Constitutively activated phosphatidylinositol 3-kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation.
Topics: Androstadienes; Blood Platelets; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Aggregation; Thrombopoietin; Tyrosine; Wortmannin | 2004 |
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Topics: Benzamides; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Deoxyglucose; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Jurkat Cells; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Monosaccharide Transport Proteins; Phloretin; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinases; Pyrimidines; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases; Tyrosine; Up-Regulation | 2005 |
Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia.
Topics: Antineoplastic Agents; Benzamides; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Culture Techniques; Cell Proliferation; Cytokines; Enterotoxins; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocyte Activation; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 2005 |
Differential tyrosine phosphorylation of leukemic cells during apoptosis as a result of treatment with imatinib mesylate.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Electrophoresis, Gel, Two-Dimensional; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proteome; Pyrimidines; Transcription, Genetic; Tyrosine | 2005 |
Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells.
Topics: Adamantane; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Cells, Cultured; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Humans; Hydroquinones; Imatinib Mesylate; Inhibitory Concentration 50; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Phosphorylation; Piperazines; Pyrimidines; Tyrosine | 2006 |
Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Isotope Labeling; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Oncogene Protein v-cbl; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Pyrimidines; Tyrosine | 2006 |
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.
Topics: Apoptosis; Benzamides; beta Catenin; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Fusion Proteins, bcr-abl; Glycogen Synthase Kinase 3; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Models, Biological; Phosphorylation; Piperazines; Protein Binding; Protein-Tyrosine Kinases; Pyrimidines; RNA, Small Interfering; Signal Transduction; Transcription, Genetic; Tyrosine | 2007 |
Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells.
Topics: 3T3 Cells; Animals; Cell Surface Extensions; Fibroblasts; HL-60 Cells; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macrophages; Mice; Phosphorylation; Proto-Oncogene Proteins c-hck; Recombinant Proteins; STAT5 Transcription Factor; Transformation, Genetic; Tyrosine; U937 Cells | 2007 |
BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia.
Topics: Antigens, CD34; Benzamides; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Green Fluorescent Proteins; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcr; Pyrimidines; ras Proteins; Retroviridae; Tyrosine | 2007 |
Interferon-alpha or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation.
Topics: Aged; Fusion Proteins, bcr-abl; Harringtonines; Homoharringtonine; Humans; Interferon-alpha; Isoleucine; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mutation; Salvage Therapy; Tyrosine | 2007 |
Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia.
Topics: Adult; Aged; Benzamides; Cell Proliferation; Cells, Cultured; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoblotting; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Phosphorylation; Piperazines; Precursor Cells, B-Lymphoid; Protein Conformation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Sequence Deletion; Tyrosine | 2008 |
CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cytoskeletal Proteins; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nuclear Proteins; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine phosphorylated proteins in chronic myelogenous leukemia.
Topics: Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; GTPase-Activating Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tumor Cells, Cultured; Tyrosine; Ultracentrifugation | 1993 |
Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.
Topics: 3T3 Cells; Animals; Benzoquinones; Catechols; Cell Differentiation; Cell Division; Cell Line; ErbB Receptors; Fusion Proteins, bcr-abl; Humans; Kinetics; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Structure; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Platelet-Derived Growth Factor; Rifabutin; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1993 |
Inhibition of erythroid differentiation by stem cell factor in K562 cells expressing the c-kit gene.
Topics: Blotting, Northern; Cell Differentiation; Cell Transformation, Neoplastic; Cytarabine; DNA, Neoplasm; Erythroid Precursor Cells; Erythropoiesis; Flow Cytometry; Gene Expression Regulation, Neoplastic; Hematopoietic Cell Growth Factors; Hemin; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; RNA, Messenger; Stem Cell Factor; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Effect of herbimycin A, an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Fusion Proteins, bcr-abl; Genistein; Humans; Isoflavones; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Tyrosine | 1994 |
Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Alkaloids; Amino Acid Sequence; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Molecular Weight; Neutrophils; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Staurosporine; Tyrosine | 1994 |
Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Line; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Structure-Activity Relationship; Tyrosine | 1995 |
Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice.
Topics: Animals; Base Sequence; Clone Cells; DNA Primers; Female; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Genes, abl; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, T-Cell; Male; Metallothionein; Mice; Mice, Transgenic; Molecular Sequence Data; Pedigree; Phosphotyrosine; Promoter Regions, Genetic; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; RNA, Messenger; Tissue Distribution; Tyrosine | 1995 |
Inhibition of protein-tyrosine kinase activity in intact cells by the aptameric action of oligodeoxynucleotides.
Topics: Base Sequence; Cell Division; Cell Line; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphotyrosine; Protein-Tyrosine Kinases; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 1995 |
The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD34; B-Lymphocyte Subsets; Biomarkers, Tumor; Blast Crisis; Bone Marrow; Cell Line; Cell Separation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Line; Electrophoresis, Polyacrylamide Gel; Fusion Proteins, bcr-abl; Glutathione Transferase; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Weight; Nuclear Proteins; Oncogene Protein v-cbl; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Tumor Cells, Cultured; Tyrosine | 1995 |
Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fusion Proteins, bcr-abl; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Microfilament Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rabbits; Talin; Tensins; Tyrosine; Vinculin | 1995 |
Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Neoplasm Proteins; Neutrophils; Nuclear Proteins; Phosphorylation; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Tyrosine | 1994 |
Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Cell Differentiation; Cell Division; Fusion Proteins, bcr-abl; Humans; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Philadelphia Chromosome; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Detection of P210bcr-abl in mature granulocytes from Ph1-positive chronic myelogenous leukemia patients by an immunoblotting method.
Topics: Blast Crisis; Cell Differentiation; Fusion Proteins, bcr-abl; Granulocytes; Humans; Immunoblotting; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Chronic-Phase; Phosphorylation; Tyrosine | 1993 |
P210 Bcr-Abl interacts with the interleukin 3 receptor beta(c) subunit and constitutively induces its tyrosine phosphorylation.
Topics: Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macromolecular Substances; Neoplasm Proteins; Phosphorylation; Precipitin Tests; Receptors, Interleukin-3; Signal Transduction; Tyrosine | 1996 |
Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells.
Topics: Cytosol; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Interleukin-3; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphoproteins; Phosphorylation; Precipitin Tests; src-Family Kinases; Transfection; Tumor Cells, Cultured; Tyrosine | 1996 |
BCR-ABL accelerates C2-ceramide-induced apoptosis.
Topics: Apoptosis; Cell Division; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Sphingosine; Tumor Necrosis Factor-alpha; Tyrosine | 1998 |
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Bone Marrow Transplantation; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mutation; Neoplasm Transplantation; Phenylalanine; Proteins; Structure-Activity Relationship; Transfection; Tyrosine | 2000 |
Expression of a truncated first exon BCR sequence in chronic myelogenous leukemia cells blocks cell growth and induces cell death.
Topics: Adenoviridae; Animals; Apoptosis; Cell Division; Cell Survival; COS Cells; Exons; Fusion Proteins, bcr-abl; Gene Expression; Genetic Vectors; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oncogene Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Transfection; Tyrosine | 2001 |
BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model.
Topics: Animals; Fusion Proteins, bcr-abl; Gene Expression Regulation; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred NOD; Mice, SCID; Oncogene Proteins; Oncogenes; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; RNA, Messenger; Serine; Tyrosine | 2001 |
Development of interferon-alpha resistant subline from human chronic myelogenous leukemia cell line KT-1.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Transformed; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Humans; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Tyrosine | 2001 |
The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.
Topics: Animals; Base Sequence; Binding Sites; Bone Marrow Cells; Bone Marrow Transplantation; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Models, Animal; Mutation; Neoplasms, Experimental; Oncogene Proteins; Peptide Fragments; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Survival Analysis; Transduction, Genetic; Tumor Cells, Cultured; Tyrosine | 2002 |
Phenylarsine oxide augments tyrosine phosphorylation in hematopoietic cells.
Topics: Aged; Animals; Arsenicals; Blood Platelets; Busulfan; Cell Line; Dithiothreitol; Gene Rearrangement; Granulocytes; Humans; Hydroxyurea; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 1992 |
DNA-protein cross-linking between thymine and tyrosine in chromatin of gamma-irradiated or H2O2-treated cultured human cells.
Topics: Cell Line; Chromatin; Cross-Linking Reagents; DNA, Neoplasm; Dose-Response Relationship, Radiation; Free Radicals; Gamma Rays; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Thymine; Tyrosine | 1992 |
Differences in tyrosine phosphorylated proteins between cells expressing P210bcr/abl and P190bcr/abl.
Topics: Fusion Proteins, bcr-abl; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1992 |
Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines.
Topics: Fusion Proteins, bcr-abl; GTPase-Activating Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Precipitin Tests; Proteins; Tumor Cells, Cultured; Tyrosine | 1992 |
Phosphotyrosine phosphatase activity prevents the detection of P210bcr/abl protein in mature cells in chronic myelogenous leukemia even by an immunoblotting technique.
Topics: Blast Crisis; Blotting, Western; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Weight; Neoplasm Proteins; Neutrophils; Peptide Hydrolases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine | 1989 |