tyrosine has been researched along with Disease Models, Animal in 847 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (4.37) | 18.7374 |
| 1990's | 56 (6.61) | 18.2507 |
| 2000's | 341 (40.26) | 29.6817 |
| 2010's | 371 (43.80) | 24.3611 |
| 2020's | 42 (4.96) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Gong, LP; Liu, S; Liu, YT; Long, CM; Zeng, YC; Zheng, QX; Zhou, Y | 1 |
| Li, X; Liu, H; Liu, J; Xu, H; Yang, Z; Zeng, L | 1 |
| Azul, L; Figueirinha, A; Leandro, A; Queiroz, M; Seiça, R; Sena, CM | 1 |
| Chen, K; Gao, X; Hu, C; Jiang, Z; Liu, K | 1 |
| Ahring, KK; Brüel, A; Brøndum-Nielsen, K; Christensen, M; Dagnæs-Hansen, F; Jensen, E; Jensen, TG; Johannsen, M; Johansen, KS; Kjolby, M; Lund, AM; Madsen, JG; Møller, LB; Pedersen, M; Sørensen, LK | 1 |
| Cho, CH; Kim, HW; Lim, NY; Park, S; Park, SJ; Roh, KH | 1 |
| Bai, SJ; Chen, JJ; Tian, T; Wang, Y; Xie, J; Zhong, Q; Zhou, CJ | 1 |
| Ano, Y; Nakayama, H; Ohya, R; Takaichi, Y; Takashima, A; Uchida, K | 1 |
| Dunckley, T; Foley, C; Hodge, JJL; Hulme, C; Parsons, T; Shaw, Y; Zhu, B | 1 |
| Berta, G; Csernus, V; Farkas, J; Füredi, N; Gaszner, B; Gaszner, T; Hashimoto, H; Kormos, V; Kovács, LÁ; Kun, D; Reglődi, D; Ujvári, B | 1 |
| Götz, J; Kneynsberg, A; Taylor, D; van Roijen, M | 1 |
| Anzai, N; Endou, H; Fujita, T; Hayashi, K; Hiroi, T; Iwata, Y; Jutabha, P; Kaminuma, O; Kanai, Y; Kurasawa, K; Matsuoka, K; Nishimura, T; Okayasu, I; Ouchi, M; Owada, T; Saeki, M; Sugiura, K | 1 |
| Abe, T; Awazu, M; Hashiguchi, A; Hida, M | 1 |
| Davison, AS; Gallagher, JA; Hughes, AT; Milan, AM; Ranganath, LR; Sireau, N | 1 |
| Bergmayr, C; Duschl, A; Fazekas-Singer, J; Fuerst, E; Heiden, D; Jensen-Jarolim, E; Ondracek, AS; Oostingh, GJ; Rohrhofer, J; Untersmayr, E | 1 |
| Duarte, A; Isturiz, M; Montagna, DR; Rearte, B; Ruggiero, RA; Todero, MF | 1 |
| Inoue, H; Ishibashi, T; Itabe, H; Kamioka, M; Koyama, H; Ohkawara, H; Ohtsuka, S; Shiomi, M; Sugimoto, K; Uekita, H; Wada, I; Yamagishi, S; Yamamoto, H; Yasuchika, T | 1 |
| Endou, H; Fujita, T; Hayashi, K; Kaminuma, O; Nishimura, T; Ogata, S; Saeki, M; Yamasaki, N | 1 |
| Churchill, MJ; Liguore, WA; Massaquoi, MS; Melrose, HL; Meshul, CK; Moore, C | 1 |
| Ambrosio, E; Anadón, A; Capellán, R; Crego, AL; Higuera-Matas, A; Marcos, A; Martínez-Larrañaga, MR; Moreno, M; Mª de Paz, A; Orihuel, J; Ucha, M | 1 |
| Bechmann, N; Bornstein, SR; Drechsel, A; Ehrlich, H; Helm, J; Pantovic, S | 1 |
| Hou, MC; Hsieh, YC; Hsu, CF; Huang, CC; Huang, SF; Huang, YH; Lee, TY; Li, TH; Lin, HC; Lin, MW; Liu, CW; Tsai, CY; Tsai, HC; Tsai, YL; Yang, YY | 1 |
| Bennett, AM; Enyenihi, L; Perla, S; Yi, JS | 1 |
| Aasen, T; Abdul Moin, NI; Abdul Wafi, S; Aboukameel, A; Abu-Bakar, N; Acharya, A; Ackermans, L; Adaramoye, O; Adarsh, KV; Adeosun, WA; Ahmad, NH; Ahmadi, F; Akanni, O; Akbar, M; Akbulak, RO; Akev, N; Akkaya, Ö; Al-Rashed, S; AlAbbad, S; Alabi, O; Alappat, BJ; Alcalá, S; Alcoutlabi, M; Aleppo, G; Alexander Ross, JB; Alexander, JH; Alexander, R; Alias, A; Alimba, C; Alken, FA; Allan, R; Alpers, M; Alsbou, EM; Amarasiri, SS; An, T; Anastasiadis, F; Anastassiadou, M; Anderson, KC; Andronikos, P; Anheyer, D; Annapurna, K; Anorlu, RI; Anten, MM; Anthopoulos, TD; Araujo-Castillo, RV; Aravamudhan, S; Arawwawala, LDAM; Arulsamy, N; Arunamata, A; Asghar, A; Asiri, AM; Aslanidou, T; Astrakhantseva, IV; Astutik, E; Attanayake, AP; Atwater, BD; Audureau, E; Augusto, S; Bakare, A; Banach, M; Bandelier, P; Banerjee, S; Barral, M; Bascuñán, J; Bates, FS; Bauer, NJC; Bayrak, BB; Beck, RW; Beckervordersantforth, J; Beeri, R; Begum, R; Beldi-Ferchiou, A; Bellingham, G; Ben-Tal, N; Bendib, I; Bergenstal, RM; Berger, MF; Bernasconi, G; Berry, S; Beuvon, F; Bi, WJ; Bi, Z; Bianconi, V; Bibi, I; Blank, BR; Bliemeister, E; Bobkowski, W; Bode, AM; Booth, CM; Bose, U; Boyd, K; Brancato, A; Brenmoehl, J; Brogi, E; Bronzo, P; Brooks, T; Brown, D; Brown, DN; Bruce, D; Buan, MEM; Bueno-Hernández, F; Bugielski, B; Bulavaitė, A; Buscagan, TM; Buxton, R; Caffaro, MM; Cai, Q; Cai, X; Cai, Y; Calhoun, P; Callander, N; Cambier, S; Camparo, P; Canales-Vargas, EJ; Canham, K; Cantu, J; Cao, J; Cao, JW; Cao, P; Cao, T; Cao, X; Caravella, BA; Carcadea, E; Carè, J; Carmichael, P; Carrasco Cabrera, L; Carteaux, G; Carvalho, PDS; Casarez, E; Cazorla, M; Celestrin, CP; Chakraborty, NK; Chan, B; Chandarlapaty, S; Chandgude, AL; Chang, CC; Chang, JH; Chang, X; Chang, Y; Chankhanittha, T; Chantanis, S; Chapovetsky, A; Chavan, S; Chen, B; Chen, D; Chen, F; Chen, G; Chen, H; Chen, J; Chen, K; Chen, KJ; Chen, KP; Chen, L; Chen, MA; Chen, Q; Chen, S; Chen, W; Chen, WF; Chen, X; Chen, Y; Cheng, D; Cheng, J; Cheng, Q; Cheon, GJ; Chiu, SC; Cho, CH; Cho, J; Choi, H; Choi, JS; Choi, YH; Christie, P; Chu, CH; Chu, Y; Chung, DH; Chung, F; Cline, JP; Cohen, A; Cohen, AD; Cohen, NJ; Comen, E; Compter, I; Cong, J; Cong, Z; Cooper, A; Cornud, F; Costa, C; Costa, S; Covey, A; Cowan, AM; Cramer, H; Cruz-Rivera, C; Cui, J; Cui, M; Cui, Y; Cui, YH; Culquichicón, C; Cushman, T; D'Auria, SJ; da Silva, J; Dalgediene, I; Danenberg, HD; Das, S; Dasgupta, K; Daubit, IM; de Oliveira, PD; de Prost, N; De Ruysscher, D; Dearman, K; Decato, D; Delfau-Larue, MH; Deng, L; Dhakate, SR; Dharuman, V; Di Costanzo, N; Dickler, MN; Dinehart, EE; Ding, D; Dinh, TK; Divya, KP; Djifack Tadongfack, T; Do, T; Domínguez-Roldan, R; Domínguez-Zambrano, E; Dömling, A; Donato, MD; Dong, JH; Dong, W; Dong, X; Dong, XR; Dong, Y; Dong, Z; Downs, M; Drutskaya, MS; Du, B; Du, F; Du, H; Du, L; Du, X; Duan, Z; Duangthip, D; Dunstand-Guzmán, E; Duong, F; Eckert, DJ; Edelhäuser, BAH; Eekers, DBP; Efendi, F; Efraimidis, P; Ehrenberg, H; Ehsanbakhsh, Z; Eickholt, C; Eksterowicz, J; El Mobadder, M; El-Araby, IE; El-Magd, MA; El-Tarabany, MS; Elgorban, AM; Engelmann, D; English, KL; Esfandiari, H; Eslami, B; Espinosa-Cuevas, A; Eswara, S; Faber, E; Fan, XH; Fan, Y; Fang, J; Fang, Z; Fantin, VR; Fei, P; Feng, G; Feng, H; Feng, J; Feng, X; Feng, XJ; Fennell, TR; Fernández-Moreira, V; Ferraz, ABF; Ferreras, KN; Flores, K; Flores-Pérez, I; Flox, C; Fluharty, FL; Fokouong Tchoffo, E; Folefack, GO; Foroutan, T; Fort, D; Fourati, S; Fousas, S; Frapard, T; Freguia, S; Friedman, DJ; Friedman, LS; Fu, D; Fu, Q; Fu, Y; Fujinami, S; Furihata, K; Gal, RL; Gan, H; Gao, C; Gao, F; Gao, R; Gao, SS; Gao, W; Gao, XC; Gao, Y; Gao, Z; Garozi, L; Ge, J; Georgiopoulos, A; Gerakiou, K; Ghazimirsaeed, SM; Ghazimirsaeed, ST; Gimeno, MC; Gjestad, R; Glurich, I; Goetchius, E; Goland, S; Goldstein, S; Gonçalves, CM; Gonçalves, H; Gong, Q; Gonzalez, D; Goplen, FK; Gorshkova, EN; Gotsman, I; Govindasamy, V; Granger, CB; Greco, L; Grigoriadou-Skouta, E; Grigoropoulos, P; Grivicich, I; Gromov, NV; Gruber, S; Grytczuk, M; Grzech-Leśniak, K; Gu, L; Gu, S; Gu, Z; Guadagnini, D; Guan, H; Guilliams, M; Guo, J; Guo, L; Gupta, A; Gupta, SK; Gurzu, S; Gutleb, AC; Haban, A; Hablitz, JJ; Hadisuyatmana, S; Hahn, S; Haiges, R; Hallal-Calleros, C; Hamed, M; Hammad, N; Hammer, N; Han, C; Hao, Y; Harnett, J; Has, EMM; Hassanpour, K; Hatzopoulos, D; Hawaldar, R; He, X; He, Y; He, YY; He, Z; Heberman, D; Heckl, D; Hegde, H; Henson, MA; Hernández-Velázquez, VM; Herrera, E; Hijazi, Z; Hirayama, K; Hirth, JM; Hoeben, A; Hohnloser, SH; Hong, M; Hood, K; Hoplock, LB; Hopman, WM; Horlbogen, LM; Hossein Rashidi, B; Hou, G; Hou, H; Hou, J; Hou, Y; Hu, J; Hu, W; Hu, X; Hua, W; Huang, G; Huang, H; Huang, J; Huang, T; Huang, W; Huang, Y; Huang, YD; Huang, Z; Hudis, CA; Hue, S; Huo, J; Hussain, M; Hvas, AM; Ichii, T; Ide Zeuna, J; Ilyas, S; Inoue, T; Iranzo, A; Irfan, M; Iwasa, Y; Iwashita, Y; Izgorodina, EI; J R, A; Jaber, WA; Jaborek, JR; Jacobus, SJ; Jadeja, SD; Jafarabadi, M; Jalan, D; Jamil, MI; Jarrah, S; Jarvis, D; Jayatilaka, KAPW; Jemal-Turki, A; Jeon, YK; Jeong, N; Jeong, SH; Jeong, SY; Jermy, M; Jhaveri, K; Ji, H; Ji, K; Ji, RY; Jiang, F; Jiang, J; Jiang, X; Jiang, Y; Jiao, Q; Jilani, K; Jiménez-Guerrero, P; Jin, L; Jo, YH; Johnson, JG; Johnson, ML; Jones, WS; Jose, S; Jularic, M; Jung, I; Jung, YJ; Jungen, C; Junttila, MR; Kache, S; Kahanovitch, U; Kalantzi, KI; Kallio, T; Kamnoedboon, P; Kang, CH; Kang, H; Kang, J; Kang, KW; Kapoor, P; Karmakar, D; Kartalis, A; Kauranen, P; Kazocina, A; Keikha, F; Keltai, M; Kershaw, SV; Kettani, M; Khalvati, S; Khandhar, S; Khosla, N; Kiely, CJ; Kim, CC; Kim, H; Kim, MJ; Kim, Y; Kim, YH; Kim, YT; Kimoto, E; Kiyu, A; Klatt, N; Kobayashi, M; Koh, J; Köhler, R; Kondadasula, SV; Kong, H; Kong, W; Kong, X; Kotidis, A; Kotwal, A; Kouvari, M; Kozhinov, AN; Kruger, D; Kuang, S; Kuang, Y; Kubota, M; Kuklik, P; Kumar, P; Kumar, SK; Kuo, YF; Kurup, SP; Kusuhara, H; Kuswanto, H; Lacouture, ME; Lambin, P; Lang, CC; Langroudi, FH; Lanman, RB; Larsen, OH; Laskin, J; Le, VH; Leach, M; Lee, BG; Lee, DF; Lee, DS; Lee, HJ; Lee, SB; Lee, YA; Lei, Y; Lekashvili, O; Lelj, F; Lemin, AS; Lemoine, J; Leuschner, R; Li, B; Li, BT; Li, C; Li, D; Li, F; Li, G; Li, H; Li, HW; Li, J; Li, M; Li, P; Li, Q; Li, S; Li, W; Li, X; Li, XY; Li, Y; Li, Z; Lian, Y; Liang, C; Liao, J; Liao, W; Liao, Y; Lin, D; Lin, W; Lin, YL; Lindbäck, J; Lindsay, AP; Ling, J; Linser, PJ; Liu, C; Liu, H; Liu, JJ; Liu, L; Liu, Q; Liu, SF; Liu, X; Liu, Y; Liu, Z; Liu, ZM; Lo Sterzo, C; Lo, ECM; Lobchuk, MM; Lodge, TP; Logotheti, S; Lonial, S; Lopes, G; Lopes, RD; Lopez, J; Lopez, SA; López-Santos, AL; López-Sendón, JL; Loring, Z; Louis, C; Lovita, AND; Lu, DZ; Lu, H; Lu, J; Lu, K; Lu, TT; Lu, Y; Luengo, A; Lum, LG; Luna, JM; Luo, L; Luo, R; Luo, T; Luo, X; Luo, Z; Lv, B; Lymperopoulos, N; Lyras, A; Lyu, Y; M Kannan, A; Ma, H; Ma, M; Ma, Q; Ma, S; Ma, WY; Ma, Y; Maalouf, E; Machado, FA; Maeda, K; Magrans, JO; Maharani, A; Maia, G; Mainwaring, RD; Maji, TK; Majumdar, K; Mannarino, MR; Mansuri, MS; Marinescu, SC; Markatos, G; Marquardt, S; Marraiki, N; Martens, C; Martínez, TJ; Marumo, K; Maruyama, H; Marwani, HM; Marzo, I; Masrati, G; Matamba, P; Mathialagan, S; Matys, J; Mayatra, JM; Mboua, PC; McArthur, T; McCrimmon, RJ; McIntosh, S; McSpadden, S; Medina-Campos, ON; Medvedovsky, AT; Mei, Z; Mekontso-Dessap, A; Menezes, AMB; Meng, J; Meng, P; Meng, Y; Menter, A; Mets, MB; Mets-Halgrimson, R; Metzger, T; Metzler-Nolte, N; Meyer, C; Mi, Y; Michailoviene, V; Mikrogeorgiou, A; Militz, H; Miller Iii, TF; Minarowska, A; Mir, S; Miron, I; Miyake, T; Moayer, F; Modi, S; Moeller, SJ; Mohamad, MN; Mohammed, EHM; Mokhonov, VV; Mondal, A; Moore, J; Moravcova, M; Mordi, IR; Mordi, NA; Mortensen, NP; Moscariello, C; Moser, J; Moynahan, ME; Mu, J; Mu, W; Mudduwa, LKB; Mukherjee, S; Mukhtar, A; Mulkey, DK; Murr, N; Mushtaq, Z; Muthuswamy, N; Mutlu, O; Muto, C; Myroforou, I; Na, KJ; Nabi, M; Nagornov, KO; Nagy, RJ; Naik, A; Nakajima, K; Nam, KT; Nam, YW; Namburath, M; Nammour, S; Namour, A; Namour, M; Nanan, S; Natsume, H; Nave, S; Naveed, A; Nazir, H; Ndubaku, C; Nedospasov, SA; Neradilek, MB; Newcomb, C; Nguépy Keubo, FR; Nguyen, M; Ning, J; Ning, Q; Noguchi, S; Nordahl, SHG; Nordfalk, KF; Norton, L; Noupoue, EM; Nouri, SS; Nowak, JK; Núñez, K; Oakes, K; Odegaard, JI; Ogorodnikova, OL; Ogunsuyi, O; Oh, HK; Oh, HR; Oh, KH; Ohgi, K; Okunade, KS; Oliveira, AG; Olorunfemi, G; Olsen, ML; Olson, BA; Omari, KW; Ondruschka, B; Orfali, R; Orkopoulos, A; Orlowski, RZ; Oser, SM; Oser, TK; Özcan, M; Padilla, V; Paeng, JC; Pajuelo-Lozano, N; Pal, SK; Palmieri, S; Palomeque, E; Pan, W; Panagiotakos, DB; Pandey, M; Pang, D; Pang, Q; Pangarah, CA; Panny, A; Paparella, A; Papirio, S; Papouskova, K; Parang, K; Park, HJ; Park, IK; Park, S; Parker, TL; Parkhomenko, A; Parmon, VN; Parsons, B; Parsons, J; Patel, PR; Patil, S; Patsourakos, NG; Patterson, KC; Pavlidis, P; Pedernera, M; Pedersen, R; Pedraza-Chaverri, J; Pellegrini, M; Peña-Chora, G; Pereira, EDM; Pereira, MADS; Peretz, A; Perez-Padilla, R; Perlman, GY; Perona, R; Petras, C; Phuntsho, S; Picada, JN; Pinder, TA; Piper, LFJ; Pirozzi, F; Pirro, M; Pleckaityte, M; Ploutz-Snyder, LL; Ploutz-Snyder, R; Pogorzelski, A; Poles, L; Postma, AA; Prager, A; Prakash, J; Punn, R; Pützer, BM; Qi, J; Qi, MC; Qi, Y; Qian, J; Qian, Y; Qiang, L; Qiu, J; Qu, Y; Rabiu, KA; Rahighi, S; Rahman, MM; Rahmani, B; Rajkumar, SV; Ramanathan, R; Raras, TYM; Rashi, Y; Rasool, G; Rathore, MG; Ratnawati, R; Ratola, N; Raucci, U; Ray, SK; Razavi, P; Razazi, K; Razek, S; Razi, SS; Reback, M; Reddy, K; Rees, DC; Reginatto, FH; Reich, H; Reis-Filho, JS; Ren, X; Ren, Y; Renner, G; Rey, G; Reymen, B; Riaz, M; Ricci, A; Richardson, PG; Richter, C; Riga, M; Ritchie, C; Rivoal, S; Roberts, W; Robson, ME; Rocha, GZ; Rodrigues, AD; Rogach, AL; Rojas, A; Rosenberg, A; Rosenberg, E; Rosenheck, RA; Roslan, K; Rothenberger, C; Rouschop, KMA; Rubagumya, F; Ryan, CM; Ryder, JW; Saad, MJA; Sacan, O; Sacchi, A; Sahebkar, A; Saini, A; Sainz, B; Sajo, EA; Sakizadeh, J; Saleh, AA; Salgado Júnior, IB; Salvi, R; Samoylova, YV; Samuni, A; Sanchez, DM; Sanchez-Perez, I; Santos, M; Sarapulova, A; Sardot, T; Saud, N; Sauerbier, P; Scaltriti, M; Schaeffer, B; Schalk, DL; Scherschel, K; Schijven, MP; Schreuder, HWR; Schuhmacher, M; Schultz-Lebahn, A; Schwarzl, J; Scott, JM; Sebayang, SK; Seeger, ZL; Segabinazi Peserico, C; Selenica, P; Serio, A; Seruga, B; Shah, A; Shah, C; Shah, PD; Shahrokh Tehraninezhad, E; Shan, A; Shao, Z; Sharma, AMR; Sharma, RK; Shen, J; Shen, R; Shi, X; Shi, Y; Shi, ZE; Shih, YC; Shimohata, H; Shimpi, N; Shin, SH; Shon, HK; Shuvy, M; Siddique, AB; Siegbahn, A; Sikandar, M; Silvani, Y; Singh, A; Singh, AK; Singh, D; Singh, JS; Singh, KP; Singh, M; Situ, B; Skipper, MT; Skouloudi, M; Sloane, BF; Smyrnioudis, N; Snyder, MA; Söhnchen, C; Solis Condor, R; Solit, DB; Someya, S; Song, H; Song, J; Song, W; Song, Y; Sorokina, KN; Soshi, S; Soyer, P; Spitschak, A; Sreekrishnan, TR; Srinivasan, M; Staruschenko, A; Steel, A; Stefan-van Staden, RI; Stein, AM; Strayer, H; Struthers, AD; Su, H; Su, Q; Su, X; Sudore, RL; Sugimura, H; Sugiyama, Y; Sujuti, H; Sumner, SJ; Sun, B; Sun, D; Sun, H; Sun, J; Sun, JY; Sun, X; Sun, Y; Sun, Z; Sung, YC; Surenaud, M; Sutimantanapi, D; Suwandaratne, NS; Swaroop, S; Sychrova, H; Syed, A; Szczepanik, M; Szederjesi, J; Szodorai, R; Tacy, TA; Tadelle, RM; Takayasu, M; Tammeveski, K; Tan, H; Tan, M; Tang, HX; Tang, S; Tang, X; Tanokura, M; Tao, F; Tao, H; Tarafdari, A; Tarín-Carrasco, P; Tasson Tatang, C; Teixeira, JP; Thakur, A; Theobald, A; Thevenot, P; Thomaidis, K; Tian, J; Tillib, SV; Toma, C; Tomita, M; Tonchev, I; Tong, F; Toy, W; Trypuć, M; Tselepis, AD; Tsetseris, L; Tsikouri, GE; Tsikouris, EI; Tsoplifack, CB; Tsoumani, ME; Tsujimoto, R; Tsybin, YO; Tu, J; Tu, TM; Turco, M; Turkyilmaz, IB; Uddin, MJ; Ung, J; Unsihuay, D; Utsunomiya, T; Vagenende, B; Vaishnav, J; Valdes, C; Validad, MH; Valle, J; van Ginkel, MPH; van Grevenstein, WMU; Vanderpuye, V; Vasan, N; Vasilenko, EA; Vasques, GJ; Vavoulis, P; Verani, A; Veziroglu, E; Viegas, A; Vitali, MG; Vitsas, G; Voccio, JP; Vogiatzidis, C; Volow, A; Volpin, F; Vourvahis, M; Wagner, LI; Walkowiak, J; Wallace, R; Wallentin, L; Wan, D; Wan, L; Wan, T; Wang, C; Wang, F; Wang, FN; Wang, H; Wang, J; Wang, L; Wang, Q; Wang, S; Wang, T; Wang, W; Wang, X; Wang, XW; Wang, Y; Wang, YS; Wang, Z; Ward, J; Ward, L; Waseem, R; Watson, DF; Weber, P; Wehrmeister, FC; Wei, CH; Wei, H; Wei, L; Wei, Q; Wei, Y; Weinstock, RS; Weiss, M; Welborn, M; Wen, L; Wen, LM; Wen, Q; Wen, Z; Wesseling, P; Westerbergh, J; White, K; Wick, MP; Willems, S; Wiyasa, IWA; Wójciak, R; Wolkenhauer, O; Won, HH; Wong, J; Woo, YC; Wood, LS; Wu, CT; Wu, CY; Wu, D; Wu, G; Wu, J; Wu, K; Wu, M; Wu, Q; Wu, T; Wu, W; Wu, X; Wu, XT; Wu, Y; Xi, D; Xi, J; Xiang, W; Xiang, Y; Xiao, M; Xiao, Z; Xie, H; Xie, Q; Xie, S; Xie, X; Xing, M; Xing, YL; Xu, C; Xu, X; Xu, Y; Xu, Z; Xue, F; Xue, XD; Yaglioglu, HG; Yamada, H; Yamashita, M; Yan, W; Yan, Z; Yanardag, R; Yang, D; Yang, H; Yang, K; Yang, QQ; Yang, R; Yang, S; Yang, T; Yang, X; Yang, Y; Yao, H; Yao, Y; Yari, D; Yassin, MT; Ye, C; Ye, J; Ye, Q; Yildiz, EA; Ying, S; Yoon, H; Yu, D; Yu, K; Yu, N; Yu, PL; Yuan, C; Yuan, D; Yuan, LJ; Yuan, Z; Yuen, N; Zagatto, AM; Zakaria, Y; Zalewski, AM; Zamora, S; Zavorotinskaya, T; Zeid, JL; Zeinoun, T; Zeng, C; Zerby, HN; Zhan, X; Zhang, A; Zhang, D; Zhang, E; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, M; Zhang, P; Zhang, Q; Zhang, QY; Zhang, RG; Zhang, S; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, CK; Zhao, H; Zhao, J; Zhao, K; Zhao, Q; Zhao, S; Zhao, T; Zhao, XQ; Zhao, Y; Zhao, Z; Zheng, J; Zheng, L; Zheng, Y; Zhou, B; Zhou, G; Zhou, L; Zhou, T; Zhou, X; Zhu, C; Zhu, J; Zhu, Y; Zhu, ZQ; Zhuang, T; Zimmermannova, O; Zin, NNINM; Zisimos, K; Zoghebi, KA; Zonder, JA; Zou, C; Zwirner, J | 1 |
| Fu, J; Wang, K; Wang, Y | 1 |
| Gao, Y; Huang, H; Li, X; Li, Y; Lin, Y; Qian, P; Tan, Y; Xu, L; Xu, X; Zhao, Y | 1 |
| Cai, D; Guo, F; Holm, L; Li, Y; Liu, HY; Zhang, K; Zhou, B | 1 |
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| Chen, L; Li, S; Liu, C; Liu, G; Sun, D; Wang, Y; Wang, Z; Zuo, B | 1 |
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| Gozal, E; Ovechkin, AV; Roberts, AM; Sedoris, KC; Theile, AR | 1 |
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| Ballinger, C; Dickinson, DA; Huang, WT; Kavanagh, TJ; Liu, RM; Matthews, QL; Postlethwait, EM; Vayalil, PK; Wang, S | 1 |
| Connelly, R; Enkhbaatar, P; Hamahata, A; Herndon, DN; Lange, M; Nakano, Y; Schmalstieg, FC; Traber, DL; Traber, LD | 1 |
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| Bryant, L; Chen, Z; Doyle, T; Ghaffari, M; Little, JW; Neumann, WL; Porreca, F; Salvemini, D | 1 |
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| Boontheung, P; Filler, SG; Loo, JA; Phan, QT; Solis, NV; Zhu, W | 1 |
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| Benedek, G; Horváth, G; Kovács, G; Mallareddy, JR; Petrovszki, Z; Tóth, G | 1 |
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| Dhammu, TS; Gilg, AG; Khan, M; Sakakima, H; Shunmugavel, A; Singh, AK; Singh, I | 1 |
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| Corcionivoschi, N; Friedmacher, F; Gosemann, JH; Puri, P; Takahashi, H | 1 |
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| Chen, CP; Kitani, K; Park, JC; Rhyu, DY; Tanaka, T; Yokozawa, T | 1 |
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| Higuchi, Y; Laskowitz, DT; McGirt, MJ; Oury, TD; Parra, A; Pearlstein, RD; Sheng, H; Warner, DS | 1 |
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| Alexander, CB; Baldus, S; Brennan, ML; Eiserich, JP; Freeman, BA; Jackson, RM | 1 |
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| Avraham, Y; Berry, EM; Hao, S; Mendelson, S | 1 |
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| Baker, J; Behzadian, MA; Caldwell, RB; Hunt, RC; Khalil, IE; Liou, GI; Marcus, DM; Matragoon, S; Pakalnis, VA; Roon, P; Samuel, S | 1 |
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| Clark, CI; Fairlie, DP; Guthrie, T; Hansford, KA; Martin, JL; McGeary, RP; Reid, RC; Schafer, K; Tyndall, JD; Whitehouse, MW | 1 |
| Chade, AR; Feldstein, A; Lerman, A; Lerman, LO; Napoli, C; Sawamura, T; Wilson, SH | 1 |
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| Alonso, D; Bentura, ML; Castro-Blanco, S; Fernández, AP; Fernández-Vizarra, P; Leza, JC; Lisazoaín, I; López, JC; Lorenzo, P; Manuel Encinas, J; Martínez, A; Martinez-Murillo, R; Pedrosa, JA; Peinado, MA; Rodrigo, J; Serrano, J | 1 |
| Ali, RR; Dick, AD; Hughes, EH; Luthert, PJ; Murphy, CC; Sarra, GM; Schlichtenbrede, FC | 1 |
| Bird, MI; Bovin, NV; Nifantiev, NE; Pochechueva, TV; Preobrazhenskaya, ME; Rieben, R; Sablina, MA; Tsvetkov, YE; Tuzikov, AB; Ushakova, NA | 1 |
| Hata, K; Miyagi, T; Obinata, M; Sasaki, A; Sawada, M; Suzuki, H; Suzuki, S; Tateno, H; Wada, T; Yamaguchi, K | 1 |
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| Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA | 1 |
| al-Dhalimy, M; Finegold, M; Grompe, M; Kennaway, NG; Lindstedt, S; Ou, CN; Papaconstantinou, J; Torres-Ramos, CA | 1 |
| Beckman, JS; Eloby-Childress, S; Kakkis, JL; Miller, MJ; Munshi, UK; Rossi, JL; Sadowska-Krowicka, H; Sandoval, M; Thompson, JH; Zhang, XJ | 1 |
| Caldwell, RB; Roque, RS | 1 |
| Holdener, BC; Magnuson, T | 1 |
| Carteaux, JP; Clozel, JP; Falivene, L; Hess, P; Roux, S | 1 |
| Beermann, F; Grund, C; Kelsey, G; Ruppert, S; Schütz, G; Tanguay, RM | 1 |
| Ebisui, C; Homma, T; Iijima, S; Kan, K; Kido, Y; Mori, T; Tsujinaka, T; Yano, M | 1 |
| Ishiwata, K; Kubota, K; Kubota, R; Murakami, M; Senda, M | 1 |
| Imamura, T; Isshiki, G; Nakajima, T; Oura, T; Sawada, Y; Shintaku, H | 1 |
| Al-Dhalimy, M; Brantly, M; Finegold, M; Grompe, M; Ou, CN; Overturf, K; Tanguay, R | 1 |
| Bachmann, C; Cervantes, H; Colombo, JP; Kokorovic, M; Perritaz, R | 1 |
| Holme, E; Lindstedt, S | 1 |
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| Avraham, Y; Berry, EM; Bonne, O | 1 |
| Diamond, A | 1 |
| Beal, MF; Galpern, WR; Isacson, O; Matthews, RT | 1 |
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| Augusto, O; Capurro, Mde L; de Bianchi, AG; Giorgio, S; Linares, E | 1 |
| al-Dhalimy, M; Finegold, M; Grompe, M; Kay, M; Lieber, A; Ou, CN; Overturf, K; Tanguay, R | 1 |
| St-Louis, M; Tanguay, RM | 1 |
| Haupt, M; Hunsmann, G; Iafrate, AJ; Kaup, FJ; Kirchhoff, F; Kuhn, EM; Lang, SM; Nisslein, T; Skowronski, J; Stahl-Hennig, C | 1 |
| Abramson, ML; Beil, ME; Chatelain, RE; Odorico, LM; Webb, RL | 1 |
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| Beal, MF; Ferrante, RJ; Jenkins, BG; Kaddurah-Daouk, R; Matthews, RT; Rosen, BR; Yang, L | 1 |
| Al-Dhalimy, M; Finegold, M; Grompe, M; Manning, K; Ou, CN; Overturf, K | 1 |
| Möhler, M; Stremmel, W; Wagner, V | 1 |
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| Ischiropoulos, H | 1 |
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| Bankiewicz, KS; Bringas, J; Eberling, JL; Jagust, WJ; Pivirotto, P; Taylor, S; VanBrocklin, HF | 1 |
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| Goldberg, P; Hussain, SN; Kristof, AS; Laubach, V | 1 |
| Bander, NH; Feldman, M; Hicklin, DJ; Prewett, M; Rothman, M; Waksal, H | 1 |
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| Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Chakravortty, D; Kato, Y; Koide, N; Morikawa, A; Sugiyama, T; Yokochi, T; Yoshida, T | 1 |
| Buurman, WA; Forget, PP; ter Steege, JC | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S | 1 |
| Hortobagyi, GN; Hung, MC; Lau, YK; Xia, W; Zhang, L | 1 |
| Andreassen, OA; Beal, MF; Bogdanov, MB; Ferrante, RJ; Kaddurah-Daouk, R; Klein, AM; Klivenyi, P; Matthews, RT; Mueller, G; Wermer, M | 1 |
| Blazar, BR; Haddad, IY; Ingbar, DH; Milla, CE; Panoskaltsis-Mortari, A; Yang, S | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E; Micali, A; Zingarelli, B | 1 |
| Connor, JR; Currie, MG; Fernandes, JC; Jovanovic, D; Lascau-Coman, V; Manning, P; Martel-Pelletier, J; Pelletier, JP | 1 |
| Balligand, JL; Combet, S; Devuyst, O; Goffin, E; Lameire, N; Moulin, P; Piech, A; Van Landschoot, M; Verbavatz, JM | 1 |
| Al-Dhalimy, M; Finegold, M; Grompe, M; Manning, K | 1 |
| Caputi, AP; Cuzzocrea, S; El-Sokkary, GH; Hassanein, AF; Reiter, RJ; Tan, DX | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; De Sarro, A; Mazzon, E | 1 |
| Cha, CI; Chung, YH; Gurney, ME; Kim, YS; Lee, KW; Shin, CM; Shin, DH | 1 |
| Andersen, JK; Andreassen, OA; Beal, MF; Bogdanov, M; Dedeoglu, A; Ferrante, RJ; Jiang, D; Klivenyi, P; Lancelot, E; Mueller, G | 1 |
| Britti, D; Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E; Mazzullo, G; McDonald, MC; Mota-Filipe, H; Thiemermann, C | 1 |
| Band, H; Ikuno, Y; Kazlauskas, A; Klinghoffer, RA; Leong, FL; Miyake, S; Rosenkranz, S | 1 |
| Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV; Zborek, A | 1 |
| Byron, KL; Eble, DM; Govindarajan, G; Lou, J; Samarel, AM; Strait, JB | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Macarthur, H; Mazzon, E; Micali, A; Misko, TP; Salvemini, D | 1 |
| Abdulmalek, K; Albertini, M; Caniatti, M; Clement, MG; Hussain, SN; Lafortuna, CL; Magder, S | 1 |
| Brown, PA; Chatterjee, PK; Cuzzocrea, S; Mota-Filipe, H; Stewart, KN; Thiemermann, C; Zacharowski, K | 1 |
| Cap, A; Cohen, R; Eberhardt, RT; Farber, HW; Forgione, MA; Goldschmidt-Clermont, PJ; Heydrick, S; Klings, ES; Leopold, JA; Loscalzo, J; Moldovan, NI; Rudd, MA; Stark, R; Trolliet, M; Yaghoubi, M | 1 |
| Churchill, T; Jewell, LD; Jijon, HB; Madsen, KL; Malfair, D; Parsons, HG; Wessler, A | 1 |
| Budka, H; Groschup, MH; Guentchev, M; Haberler, C; Voigtländer, T | 1 |
| Hong, HJ; Loh, SH; Yen, MH | 1 |
| Amarasinghe, S; Bergad, PL; Berry, SA; Humbert, JT; Morrison, M; Schwarzenberg, SJ; Towle, HC | 1 |
| Ali, SF; Imam, SZ; Islam, F; Itzhak, Y; Slikker, W | 1 |
| Chen, Q; Djaldatti, R; Giasson, BI; Ischiropoulos, H; Jackson-Lewis, V; Lee, VM; Przedborski, S; Souza, JM; Vila, M; Vukosavic, S | 1 |
| Arnold, N; Bullens, SL; Bunting, S; Chamberlain, J; Chico, TJ; Crossman, DC; Francis, SE; Gadek, TR; Gunn, J; Horton, M; Knolle, J; Lipari, MT; Peyman, A; Quan, C; Shepherd, L; Stilz, HU | 1 |
| Boeckers, TM; de la Cerda, A; Grimm, R; Gundelfinger, ED; Marengo, JJ; Orrego, F; Smalla, KH; Soto, D; Tischmeyer, W; Wolf, G; Wyneken, U | 1 |
| Feustel, PJ; Kimelberg, HK; Mongin, AA; Osuka, K; Tranmer, BI | 1 |
| Caputi, AP; Centorrino, T; Ciccolo, A; Cuzzocrea, S; De Sarro, A; Dugo, L; Mazzon, E; Serraino, I | 1 |
| Bauer, JA; Mihm, MJ; Schanbacher, BL; Uretsky, NJ; Wallace, BL; Wallace, LJ | 1 |
| Lai, PS; Lin, KT; Linask, KK; Liu, X; Nagele, RG; Sun, FF; Wang, C; Wong, PY; Yin, K; Yue, G | 1 |
| Archard, LC; Bevan, AL; Li, Y; Zhang, H | 1 |
| Duff, K; La Francois, J; Matsuoka, Y; Picciano, M | 1 |
| Alonso, D; Bentura, ML; Fernández, AP; Ghiglione, M; López, JC; Martínez-Murillo, R; Richart, A; Rodrigo, J; Santacana, M; Serrano, J; Uttenthal, LO | 1 |
| Anversa, P; Barlucchi, L; Beltrami, AP; Cesselli, D; Hintze, TH; Jakoniuk, I; Kajstura, J; Leri, A; Nadal-Ginard, B | 1 |
| Fürst, P | 1 |
| Bekker, JM; Black, SM; Fineman, JR; McMullan, DM; Wedgwood, S | 1 |
| Barton, CH; Ni, Z; Vaziri, ND | 1 |
| Hickman-Davis, JM; Lindsey, JR; Matalon, S | 1 |
| Folkerts, G; Koster, AS; Muijsers, RB; Nijkamp, FP; Postma, DS; van Ark, I; van Oosterhout, AJ | 1 |
| Dobrian, AD; Prewitt, RL; Schriver, SD | 1 |
| Javeshghani, D; Magder, S | 1 |
| Belaaouaj, A; Brennan, ML; Byun, J; Gaut, JP; Heinecke, JW; Henderson, JP; Hotchkiss, RS; Lusis, AJ; Richter, GM; Tran, HD; Yeh, GC | 1 |
| Estrada-García, I; Hernandez-Pando, R; Orozco, EH; Schön, T; Serafin, J | 1 |
| Bémeur, C; Butterworth, R; Hazell, AS; Montgomery, J; Ste-Marie, L | 1 |
| Deckel, AW; Freitas, R; Gary, KA; Gordinier, A; Kuwada, C; Nuttal, D; Tang, V | 1 |
| Jokelainen, K; Lalani, EN; Lau, GK; Nanji, AA; Polavarapu, R; Rahemtulla, A; Tipoe, GL | 1 |
| Cho, S; McDonald, JD | 1 |
| Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Mazzon, E; Salvemini, D; Serraino, I | 1 |
| Alonso, D; Bentura, ML; Castro-Blanco, S; Encinas, JM; Fernández, AP; Fernández-Vizarra, P; Richart, A; Rodrigo, J; Rodríguez, I; Ruíz-Cabello, J; Santacana, M; Serrano, J; Uttenthal, LO | 1 |
| Al-Dhalimy, M; Finegold, M; Grompe, M; Overturf, K | 1 |
| Hirano, K; Iijima, H; Iishii, Y; Masuyama, K; Mochizuki, M; Morishima, Y; Nomura, A; Sakamoto, T; Sekizawa, K; Uchida, Y; Zhang, M | 1 |
| Arruda, P; Castro, GM; de Nucci, G; Langone, F; Martins, ML; Muscará, MN; Papes, F; Rogério, F; Santos, LM; Teixeira, SA | 1 |
| Choi, DK; Ischiropoulos, H; Jackson-Lewis, V; Przedborski, S; Teismann, P; Tieu, K; Vadseth, C; Vila, M; Wu, DC | 1 |
| Kumar, A; Long, Y; Yang, K; Yuan, X; Zou, L | 1 |
| Christopher, TA; Gao, E; Gao, F; Lopez, BL; Ma, XL; McLaughlin, R; Mo, QZ; Yan, WL; Yao, CL | 1 |
| Hake, PW; Malhotra, V; O'Connor, M; Sheehan, M; Wong, HR; Zingarelli, B | 1 |
| Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Mazzon, E; Sautebin, L; Serraino, I | 1 |
| Giffard, RG; Han, HS; Karabiyikoglu, M; Qiao, Y; Yenari, MA | 1 |
| Courtois, Y; Goureau, O; Sennlaub, F | 1 |
| Hill, J; Hill, R; Vona-Davis, L; Wearden, P | 1 |
| Horio, F; Kato, Y; Naito, M; Nomura, H; Osawa, T; Toyokuni, S; Tsuda, T; Uchida, K; Ueno, Y | 1 |
| Fujimoto, M; Hamaguchi, Y; Hasegawa, M; Kaburagi, Y; Komura, K; Nagaoka, T; Saito, E; Sato, S; Takehara, K; Tedder, TF | 1 |
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17 review(s) available for tyrosine and Disease Models, Animal
| Article | Year |
|---|---|
Alkaptonuria - Many questions answered, further challenges beckon.
Topics: Alkaptonuria; Animals; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Homogentisic Acid; Humans; Mice; Nitrobenzoates; Tyrosine | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Experimental evidence of tyrosine neurotoxicity: focus on mitochondrial dysfunction.
Topics: Animals; Brain; Disease Models, Animal; Energy Metabolism; Humans; Mitochondria; Neurotoxicity Syndromes; Rats; Tyrosine | 2021 |
Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Tyrosine | 2017 |
Oxidative and nitrosative events in asthma.
Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Eosinophil Peroxidase; Eosinophils; Free Radicals; Granulocytes; Humans; Inflammation; Leukocytes; Lung; Models, Biological; Neutrophils; Nitric Oxide; Nitrogen; Oxidative Stress; Oxygen; Peroxidases; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxide Dismutase; Time Factors; Tyrosine | 2003 |
Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.
Topics: Animals; Disease; Disease Models, Animal; Humans; Immune System; Mice; Oncogenes; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Tumor Suppressor Proteins; Tyrosine | 2008 |
Adverse effects of excessive consumption of amino acids.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Cattle; Diet; Disease Models, Animal; Ethionine; Fenclonine; Glycine; Growth Disorders; Histidine; Humans; Methionine; Nerve Tissue Proteins; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pneumonia, Atypical Interstitial, of Cattle; Serine; Stereoisomerism; Sulfhydryl Compounds; Tissue Distribution; Tryptophan; Tyrosine; Vitamin A | 1984 |
A mouse model for human hereditary tyrosinemia I.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Chromosome Mapping; Disease Models, Animal; Genetic Complementation Test; Humans; Mice; Mice, Mutant Strains; Tyrosine | 1994 |
Diagnosis and management of tyrosinemia type I.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Amino Acid Metabolism, Inborn Errors; Animals; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Genetic Therapy; Humans; Liver Transplantation; Nitrobenzoates; Phenotype; Tyrosine | 1995 |
Vitiligo, psoralen, and melanogenesis: some observations and understanding.
Topics: Animals; Dihydroxyphenylalanine; Disease Models, Animal; Furocoumarins; Humans; Indoles; Lead; Melanins; Skin; Superoxide Dismutase; Tryptophan; Tyrosine; Tyrosine Transaminase; Ultraviolet Rays; Vitiligo | 1996 |
Evidence for the importance of dopamine for prefrontal cortex functions early in life.
Topics: Animals; Child, Preschool; Cognition; Disease Models, Animal; Dopamine; Humans; Infant; Inhibition, Psychological; Macaca; Neural Pathways; Phenylalanine; Phenylketonurias; Prefrontal Cortex; Spatial Behavior; Task Performance and Analysis; Tyrosine; Visual Pathways | 1996 |
Mutations in the fumarylacetoacetate hydrolase gene causing hereditary tyrosinemia type I: overview.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Humans; Hydrolases; Mice; Mutation; Tyrosine | 1997 |
[Hereditary liver diseases. Recent molecular genetic aspects].
Topics: alpha 1-Antitrypsin; Animals; Bilirubin; Cholestasis, Intrahepatic; Cystic Fibrosis; Disease Models, Animal; Genetic Therapy; Hepatolenticular Degeneration; Humans; Jaundice, Chronic Idiopathic; Liver Diseases; Metabolism, Inborn Errors; Molecular Biology; Tyrosine | 1998 |
Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species.
Topics: Animals; Disease Models, Animal; Humans; Nitrates; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 1998 |
Conditionally indispensable amino acids (glutamine, cyst(e)ine, tyrosine, arginine, ornithine, taurine) in enteral feeding and the dipeptide concept.
Topics: Amino Acids, Essential; Animals; Arginine; Cysteine; Disease Models, Animal; Enteral Nutrition; Glutamine; Humans; Intestinal Mucosa; Ornithine; Taurine; Treatment Outcome; Tyrosine | 2000 |
Keratopathy in tyrosinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Cornea; Corneal Diseases; Disease Models, Animal; Enzyme Induction; Humans; Infant, Newborn; Rats; Tyrosine; Tyrosine Transaminase | 1976 |
Tyrosine-induced skin disease.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Corneal Ulcer; Diagnosis, Differential; Disease Models, Animal; Female; Humans; Infant; Keratoderma, Palmoplantar; Male; Rats; Syndrome; Tyrosine | 1978 |
4 trial(s) available for tyrosine and Disease Models, Animal
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Nitration-mediated deficiency of cystathionine β-synthase activity accelerates the progression of hyperhomocysteinemia.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Disease Progression; Female; Free Radical Scavengers; Homocysteine; Humans; Hyperhomocysteinemia; Male; Metalloporphyrins; Middle Aged; Mutation; Nitro Compounds; Nitrosative Stress; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tyrosine | 2017 |
N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI.
Topics: Acetylcysteine; Aldehydes; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Double-Blind Method; Energy Metabolism; Glutathione; Male; Maze Learning; Mitochondria; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2014 |
Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans.
Topics: Aged; Angioplasty, Balloon, Coronary; Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Ischemic Postconditioning; Leukocyte Count; Male; Malondialdehyde; Middle Aged; Molsidomine; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tyrosine; Ventricular Function, Left | 2011 |
827 other study(ies) available for tyrosine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autophagy; Disease Models, Animal; Hippocampus; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Presenilin-1; Psychomotor Performance; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Spatial Memory; Tyrosine | 2021 |
RNA-Seq Analysis Reveals an Essential Role of the Tyrosine Metabolic Pathway and Inflammation in Myopia-Induced Retinal Degeneration in Guinea Pigs.
Topics: Animals; Disease Models, Animal; Glycosaminoglycans; Guinea Pigs; Humans; Inflammation; Metabolic Networks and Pathways; Myopia; Retina; Retinal Degeneration; RNA-Seq; Tyrosine | 2021 |
Luteolin Improves Perivascular Adipose Tissue Profile and Vascular Dysfunction in Goto-Kakizaki Rats.
Topics: Adipose Tissue; Animals; Carrier Proteins; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Administration Schedule; Endothelium, Vascular; Luteolin; Male; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2021 |
Captopril alleviates oxidative damage in diabetic retinopathy.
Topics: Animals; Captopril; Cholesterol; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Endothelial Cells; Glucose; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; Retinal Vessels; Streptozocin; Tyrosine; Vascular Endothelial Growth Factor A | 2022 |
The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model.
Topics: Amino Acids; Animals; Bone and Bones; Bone Density; Brain; Caseins; Dietary Supplements; Disease Models, Animal; Female; Maze Learning; Mice; Mice, Inbred C57BL; Peptide Fragments; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Serotonin; Tyrosine | 2022 |
Role of the JAK/STAT pathway in a streptozotocin-induced diabetic retinopathy mouse model.
Topics: Animals; Diabetes Mellitus; Diabetic Retinopathy; Disease Models, Animal; Glucose; Janus Kinase Inhibitors; Janus Kinases; Mice; Mice, Inbred C57BL; Phosphorylation; RNA, Messenger; Signal Transduction; STAT Transcription Factors; STAT5 Transcription Factor; Streptozocin; Tyrosine; Vascular Endothelial Growth Factor A | 2022 |
Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice.
Topics: Amino Acids; Animals; Depression; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Neurotransmitter Agents; Tyrosine | 2022 |
Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice.
Topics: Alzheimer Disease; Animals; Dipeptides; Disease Models, Animal; Mice; Mice, Transgenic; tau Proteins; Tauopathies; Tryptophan; Tyrosine | 2023 |
DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Down Syndrome; Drosophila; Dyrk Kinases; Humans; Neurotoxicity Syndromes; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; tau Proteins; Tyrosine | 2022 |
Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy.
Topics: Animals; Calcium Carbonate; Corticotropin-Releasing Hormone; Depression; Disease Models, Animal; Fluoxetine; Histones; Male; Mice; Mixed Function Oxygenases; Pituitary Adenylate Cyclase-Activating Polypeptide; Stress, Psychological; Tyrosine; Urocortins | 2022 |
Tyrosine phosphatase STEP
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Disease Models, Animal; Frontotemporal Dementia; Humans; Mice; Mice, Transgenic; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; tau Proteins; Tyrosine | 2023 |
LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation.
Topics: Amino Acid Transport System y+L; Animals; Benzoxazoles; CD4-Positive T-Lymphocytes; Cells, Cultured; Dermatitis, Atopic; Disease Models, Animal; Humans; Large Neutral Amino Acid-Transporter 1; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Knockout; Signal Transduction; Th2 Cells; Treatment Outcome; Tyrosine | 2020 |
Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring.
Topics: Animals; Disease Models, Animal; Female; Fibrosis; Kidney; Kidney Tubular Necrosis, Acute; Male; Malnutrition; Maternal-Fetal Exchange; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Tyrosine; Ureteral Obstruction | 2019 |
Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin in an Experimental Food Allergy Model.
Topics: Allergens; Animals; Cell Line, Tumor; Chymases; Disease Models, Animal; Female; Immunoglobulin A; Interferon-gamma; Interleukin-10; Lactoglobulins; Mice, Inbred BALB C; Milk Hypersensitivity; Nitro Compounds; Protein Stability; Proteolysis; Rats; Spleen; Tyrosine | 2019 |
Meta-tyrosine modulates the immune response induced by bacterial endotoxins.
Topics: Animals; B7-H1 Antigen; Cancer Vaccines; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Immunologic Factors; Lipopolysaccharides; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Myeloid-Derived Suppressor Cells; Neoplasm Metastasis; Sepsis; Tyrosine | 2020 |
Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis.
Topics: Aging; Animals; Antigens, Neoplasm; Atherosclerosis; Disease Models, Animal; Female; Gene Knockdown Techniques; Glycation End Products, Advanced; Humans; Hyperlipidemias; Immunohistochemistry; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Plaque, Atherosclerotic; Rabbits; Receptor for Advanced Glycation End Products; Tyrosine | 2019 |
L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness.
Topics: Activating Transcription Factor 4; Animals; Benzoxazoles; Cytokines; Disease Models, Animal; gamma-Glutamylcyclotransferase; Large Neutral Amino Acid-Transporter 1; Lymphocyte Activation; Mice; Rhinitis, Allergic; Signal Transduction; T-Lymphocytes; Tyrosine | 2020 |
Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Flavones; Gait; Mice; Mice, Inbred C57BL; Parkinson Disease; Parkinsonian Disorders; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2020 |
The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats.
Topics: Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Ethanol; Female; Humans; Infusions, Intravenous; Male; Rats; Reinforcement, Psychology; Self Administration; Sex Factors; Substance-Related Disorders; Tyrosine | 2020 |
Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro.
Topics: Animals; Antineoplastic Agents; BALB 3T3 Cells; Cell Line, Tumor; Disease Models, Animal; Isoxazoles; Mice; Porifera; Spiro Compounds; Tyrosine | 2020 |
SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; Hand Strength; Mice; Mice, Inbred C57BL; Muscles; Muscular Atrophy; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Resveratrol; Sirtuin 1; Tyrosine; Up-Regulation | 2020 |
Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.
Topics: Animals; Cardiomyopathy, Hypertrophic; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; LEOPARD Syndrome; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Myocytes, Cardiac; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Tyrosine | 2020 |
HDAC6 Mediates Macrophage iNOS Expression and Excessive Nitric Oxide Production in the Blood During Endotoxemia.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endotoxemia; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Interferon Regulatory Factor-1; Macrophages, Peritoneal; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Signal Transduction; STAT1 Transcription Factor; Tyrosine | 2020 |
Tyrosine supplement ameliorates murine aGVHD by modulation of gut microbiome and metabolome.
Topics: Acute Disease; Animals; Biodiversity; Chromatography, High Pressure Liquid; Computational Biology; Dietary Supplements; Disease Management; Disease Models, Animal; Disease Susceptibility; Gastrointestinal Microbiome; Graft vs Host Disease; Intestinal Mucosa; Mass Spectrometry; Metabolome; Metabolomics; Metagenomics; Mice; Phenotype; RNA, Ribosomal, 16S; Tyrosine | 2020 |
Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis.
Topics: Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenase; Animals; Cells, Cultured; Disease Models, Animal; Fatty Acids; Gene Expression Regulation, Enzymologic; Hepatocytes; Histones; Insulin Resistance; Linoleic Acids, Conjugated; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; Oxidation-Reduction; PPAR alpha; Signal Transduction; Transcriptional Activation; Tyrosine | 2021 |
Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction.
Topics: Animals; Autophagy; Cardiomyopathies; Cardiotonic Agents; Cecum; Cell Death; Disease Models, Animal; Flavones; Glutathione; Heart; Ligation; Male; Myocardium; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Carbonylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Punctures; Rats, Sprague-Dawley; Sepsis; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Tyrosine | 2020 |
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cytoplasmic Granules; Disease Models, Animal; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Heterogeneous-Nuclear Ribonucleoprotein Group F-H; Humans; Microtubule-Associated Proteins; Models, Molecular; Mutation; Nerve Degeneration; Neurodegenerative Diseases; Phosphorylation; Protein Conformation; Protein Domains; Tyrosine | 2021 |
Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation.
Topics: Animals; Cyclohexanones; Disease Models, Animal; Glutathione; Humans; Hydrolases; Liver; Liver Regeneration; Medication Adherence; Mice; Mice, Knockout; NF-E2-Related Factor 2; Nitrobenzoates; Oxidative Stress; Oxidoreductases; Signal Transduction; Tyrosine; Tyrosinemias; Withholding Treatment | 2020 |
Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy.
Topics: Adult; Aged; Animals; Cardiac Myosins; Cardiomyopathy, Hypertrophic; Carrier Proteins; Case-Control Studies; Disease Models, Animal; Female; Haploinsufficiency; Humans; Male; Middle Aged; Myosin Heavy Chains; Proteomics; Sarcomeres; Troponin I; Troponin T; Tubulin; Tyrosine; Ventricular Outflow Obstruction; Ventricular Septum | 2021 |
Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds.
Topics: 3T3 Cells; Animals; Burns; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Fish Oils; Hippophae; Keratinocytes; Mice; Re-Epithelialization; Sheep; Telomerase; Tyrosine; Wound Healing | 2021 |
Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice.
Topics: Administration, Oral; Alzheimer Disease; Animals; Behavior, Animal; Calcium Channel Agonists; Calcium Channels, T-Type; Cognition; Disease Models, Animal; Drug Administration Schedule; Hippocampus; Imidazoles; Male; Mice; Microglia; Molecular Structure; Olfactory Bulb; Oxidative Stress; Spatial Memory; Spiro Compounds; Tyrosine | 2021 |
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models, Animal; Enzyme Activation; Glucose Transporter Type 4; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Phosphorylation; Plant Extracts; Rats; Rosmarinus; Serine; TOR Serine-Threonine Kinases; Tyrosine | 2021 |
Microbial metabolism of L-tyrosine protects against allergic airway inflammation.
Topics: Administration, Oral; Allergens; Animals; Antibodies; Antibody Diversity; Bacteria; Cells, Cultured; Chemokine CCL20; Coculture Techniques; Cresols; Disease Models, Animal; ErbB Receptors; Female; Gastrointestinal Microbiome; Host-Pathogen Interactions; Injections, Intravenous; Intestines; Lung; Male; Mice, Inbred C57BL; Mice, Transgenic; Pneumonia; Respiratory Hypersensitivity; Signal Transduction; Sulfuric Acid Esters; Toll-Like Receptor 4; Tyrosine | 2021 |
Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.
Topics: Animals; Cardiac Myosins; Cardiomyopathy, Hypertrophic; Carrier Proteins; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Humans; Hypertrophy, Left Ventricular; Induced Pluripotent Stem Cells; Male; Mice, Inbred C57BL; Mutation, Missense; Myocardial Contraction; Myocytes, Cardiac; Myosin Heavy Chains; Peroxidase; Phosphorylation; Reactive Oxygen Species; Tyrosine; Ventricular Function, Left | 2022 |
Topics: Animals; Anti-Inflammatory Agents; Basidiomycota; Bile Acids and Salts; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Forkhead Transcription Factors; Fungal Polysaccharides; Gastrointestinal Microbiome; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Mice, Inbred C57BL; Molecular Weight; Protective Agents; RNA, Ribosomal, 16S; Signal Transduction; T-Lymphocytes, Regulatory; Treatment Outcome; Tryptophan; Tyrosine | 2021 |
Employing metabolomic approaches to determine the influence of age on experimental autoimmune encephalomyelitis (EAE).
Topics: Age Factors; Aging; Animals; Autoimmunity; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Unsaturated; Female; Interleukin-6; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; NADPH Oxidases; Risk Factors; Sphingolipids; Spinal Cord; Tryptophan; Tyrosine | 2021 |
Site-specific identification and validation of hepatic histone nitration in vivo: Implications for alcohol-induced liver injury.
Topics: Amino Acid Sequence; Animals; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Ethanol; Histones; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Dynamics Simulation; Nitrates; Oxidative Stress; Tandem Mass Spectrometry; Tyrosine | 2021 |
Mass spectrometry-based urinary metabolomics for exploring the treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer's disease in rats.
Topics: Alzheimer Disease; Animals; Biomarkers; Brain; Disease Models, Animal; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Inflammation; Mass Spectrometry; Medicine, Chinese Traditional; Metabolomics; Nervous System; Panax; Phenylalanine; Plant Extracts; Rats; Reproducibility of Results; Schisandra; Tandem Mass Spectrometry; Tyrosine; Urinalysis | 2021 |
Acidic Microenvironment Aggravates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating M1-Polarization Through Regulating PPAR-γ Signal.
Topics: Animals; Benzophenones; Cells, Cultured; Cellular Microenvironment; Disease Models, Animal; Hydrogen-Ion Concentration; Immunity, Innate; Kupffer Cells; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; PPAR gamma; Reperfusion Injury; Severity of Illness Index; Signal Transduction; Sodium Bicarbonate; Tyrosine | 2021 |
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[
Topics: alpha-Synuclein; Animals; Dependovirus; Disease Models, Animal; Disease Progression; Dopaminergic Neurons; Fluorine Radioisotopes; Male; Motor Activity; Parkinson Disease; Phosphorylation; Positron-Emission Tomography; Protein Aggregates; Rats, Sprague-Dawley; Synucleinopathies; Tyrosine | 2021 |
Omega-3 fatty acid supplementation decreases DNA damage in brain of rats subjected to a chemically induced chronic model of Tyrosinemia type II.
Topics: Animals; Antioxidants; Brain; Disease Models, Animal; DNA Damage; Fatty Acids, Omega-3; Male; Oxidative Stress; Rats; Rats, Wistar; Tyrosine; Tyrosinemias | 2017 |
Selective effects of oral antiangiogenic tyrosine kinase inhibitors on an animal model of hereditary hemorrhagic telangiectasia.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Administration, Oral; Administration, Topical; Anemia; Angiogenesis Inhibitors; Animals; Arteriovenous Malformations; Disease Models, Animal; Erlotinib Hydrochloride; Gastrointestinal Hemorrhage; Hemoglobins; Image Processing, Computer-Assisted; Indazoles; Mice; Mice, Knockout; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrimidines; Skin; Sorafenib; Sulfonamides; Sulfones; Telangiectasia, Hereditary Hemorrhagic; Tyrosine; Vascular Endothelial Growth Factor A; Wound Healing | 2017 |
Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex.
Topics: Acetophenones; Afferent Pathways; Aldehydes; Animals; Antioxidants; Ascorbic Acid; Biotin; Brain Injuries; Dendrites; Dextrans; Disease Models, Animal; Electron Transport Complex IV; Epidural Space; Functional Laterality; Male; Neurons; Oxidative Stress; Rats; Somatosensory Cortex; Thalamus; Time Factors; Tyrosine | 2017 |
Tyrosine Phosphorylation of NR2B Contributes to Chronic Migraines via Increased Expression of CGRP in Rats.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Disease Models, Animal; Genistein; Humans; Hyperalgesia; Male; Migraine Disorders; Neurons; Pain Measurement; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2017 |
Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Heterografts; Hydroxylation; Kinetics; Liver Neoplasms; Mass Spectrometry; Mice; Mice, Nude; Phenylalanine; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; Tyrosine | 2017 |
Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration.
Topics: Adipose Tissue; Animals; Biocompatible Materials; Cell Survival; Disease Models, Animal; Gelatin; Humans; Hydrogels; Isoleucine; Maleic Anhydrides; Morpholines; Nerve Regeneration; Peptides; Polycarboxylate Cement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Shear Strength; Stem Cells; Tyrosine | 2017 |
Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta, Thoracic; Arterial Pressure; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Hypertension; Male; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidase 4; Nitric Oxide; Oxidative Stress; Renal Artery; Sodium Nitrite; Tyrosine; Vasodilation | 2018 |
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cisplatin; Cytokines; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Inflammation Mediators; Kidney; Male; Malondialdehyde; Membrane Proteins; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphorylation; Signal Transduction; Tyrosine | 2017 |
Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome.
Topics: Animals; bcl-2-Associated X Protein; Complex Regional Pain Syndromes; Disease Models, Animal; Ethanolamines; Immunohistochemistry; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Mice; Nerve Growth Factor; Proto-Oncogene Proteins c-bcl-2; Tibia; Tibial Fractures; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
Poly-ADP ribose polymerase-14 limits severity of allergic skin disease.
Topics: Adoptive Transfer; Animals; Cells, Cultured; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease; Homeodomain Proteins; Keratinocytes; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; Poly(ADP-ribose) Polymerases; Severity of Illness Index; Signal Transduction; Skin; STAT6 Transcription Factor; Th2 Cells; Tyrosine | 2017 |
Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain.
Topics: Animals; Brain Ischemia; Cell Death; Cerebral Arteries; Cerebrovascular Circulation; Cyclooxygenase 2; Disease Models, Animal; Prostaglandin-E Synthases; Rats, Wistar; Reperfusion; Reperfusion Injury; Treatment Outcome; Tyrosine; Ultrasonography | 2017 |
Experimental studies on possible regulatory role of nitric oxide on the differential effects of chronic predictable and unpredictable stress on adaptive immune responses.
Topics: Adaptive Immunity; Animals; Brain; Chronic Disease; Disease Models, Animal; Hypersensitivity, Delayed; Immunity, Humoral; Immunoglobulin G; Immunosuppression Therapy; Male; Nitric Oxide; Rats; Restraint, Physical; Stress, Psychological; Tyrosine | 2017 |
Abnormal social behavior in mice with tyrosinemia type I is associated with an increase of myelin in the cerebral cortex.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Mice; Myelin Sheath; Social Behavior; Tyrosine; Tyrosinemias | 2017 |
Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Fusion Proteins, bcr-abl; Guanine Nucleotide Exchange Factors; Humans; Leukemia; Mice; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rac1 GTP-Binding Protein; SOS1 Protein; Tyrosine | 2018 |
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Topics: Amidohydrolases; Animals; Arginine; Atrial Natriuretic Factor; Disease Models, Animal; Fibrosis; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular; Male; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide; Phenotype; Signal Transduction; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2017 |
The Anti-Inflammatory and Antioxidant Potential of Pistachios (Pistacia vera L.) In Vitro and In Vivo.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophages; Male; Mice; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nuts; Oxidative Stress; Phytotherapy; Pistacia; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis.
Topics: Alginates; Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Endoplasmic Reticulum Stress; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Nitrosative Stress; Oligosaccharides; Oxidative Stress; Superoxides; Tyrosine | 2017 |
A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Female; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; Oxazoles; PPAR alpha; Protein Interaction Maps; RNA, Messenger; Sex Characteristics; Sex Factors; Signal Transduction; Systems Biology; Time Factors; Tyrosine | 2017 |
Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Cholesterol, Dietary; Diet; Dietary Fats; Disease Models, Animal; Endotoxins; Fatty Liver; Female; Fructose; Gastrointestinal Microbiome; Intestine, Small; Lipid Peroxidation; Lipogenesis; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Occludin; Toll-Like Receptor 4; Triglycerides; Tyrosine; Zonula Occludens-1 Protein | 2017 |
Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator.
Topics: Animals; Brain; Brain Ischemia; Cerebral Hemorrhage; Disease Models, Animal; Male; Matrix Metalloproteinase 3; Peroxynitrous Acid; Rats, Wistar; Reperfusion Injury; Tissue Plasminogen Activator; Tyrosine | 2018 |
Thioredoxin-1 attenuates sepsis-induced cardiomyopathy after cecal ligation and puncture in mice.
Topics: Aldehydes; Animals; Apoptosis; Capillary Permeability; Cardiomyopathies; Carrier Proteins; Caspase 3; Disease Models, Animal; Echocardiography; Female; Heart; Heme Oxygenase-1; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Oxidative Stress; Repressor Proteins; Sepsis; Survivin; Thioredoxins; Tyrosine | 2017 |
Induction of Neuroinflammatory Response and Histopathological Alterations Caused by Quinolinic Acid Administration in the Striatum of Glutaryl-CoA Dehydrogenase Deficient Mice.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic; CD3 Complex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutaryl-CoA Dehydrogenase; Inflammation; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Quinolinic Acid; S100 Calcium Binding Protein beta Subunit; Statistics, Nonparametric; Time Factors; Tyrosine | 2018 |
Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke.
Topics: Animals; Antioxidants; Caspase 3; Cell Survival; Cells, Cultured; Disease Models, Animal; Humans; Ischemia; Mice; Mice, Inbred C57BL; Microglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Reactive Oxygen Species; Stroke; Tyrosine | 2018 |
Important role of endothelium-dependent hyperpolarization in the pulmonary microcirculation in male mice: implications for hypoxia-induced pulmonary hypertension.
Topics: Animals; Biological Factors; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; Male; Membrane Potentials; Mice, Inbred C57BL; Microcirculation; Nitric Oxide; Pulmonary Artery; Pulmonary Circulation; Signal Transduction; Tyrosine; Vascular Remodeling; Vasodilation; Vasodilator Agents | 2018 |
Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Frontotemporal Dementia; Gene Expression; HEK293 Cells; Heterogeneous-Nuclear Ribonucleoprotein Group F-H; Humans; Mutagenesis, Site-Directed; Mutation; Photoreceptor Cells, Invertebrate; Protein Domains; Protein Folding; Recombinant Fusion Proteins; Retinal Degeneration; Tyrosine | 2018 |
Curcumin exerts a protective effect against premature ovarian failure in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Mullerian Hormone; Apoptosis; Curcumin; Cyclin-Dependent Kinase Inhibitor p16; Deoxyguanosine; Disease Models, Animal; Female; Galactose; Gonads; Hypothalamo-Hypophyseal System; Mice, Inbred C57BL; Ovary; Oxidative Stress; Primary Ovarian Insufficiency; Protective Agents; RNA, Messenger; Tyrosine | 2018 |
Tandem tyrosine phosphosites in the Enteropathogenic Escherichia coli chaperone CesT are required for differential type III effector translocation and virulence.
Topics: Animals; Disease Models, Animal; Enteropathogenic Escherichia coli; Escherichia coli Infections; Escherichia coli O157; Escherichia coli Proteins; Female; HeLa Cells; Humans; Intestinal Diseases; Mice; Mice, Inbred C57BL; Molecular Chaperones; Organophosphates; Polymers; Tyrosine; Virulence; Virulence Factors | 2018 |
USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.
Topics: Adenine; Adenovirus Infections, Human; Adenoviruses, Human; Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; Immunocompromised Host; Liver; Mesocricetus; Organophosphonates; Prodrugs; Survival Analysis; Treatment Outcome; Tyrosine | 2018 |
Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress.
Topics: Amidohydrolases; Animals; Corticosterone; Cytokines; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Hippocampus; Inflammation Mediators; Male; Nitrates; Nitric Oxide; Nitrites; Nitrosative Stress; Piperidines; Pyridines; Rats, Wistar; Restraint, Physical; Signal Transduction; Stress, Psychological; Time Factors; Tyrosine | 2018 |
Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis.
Topics: Animals; Aorta; Atherosclerosis; Blood Urea Nitrogen; Creatinine; Diet, Fat-Restricted; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Disease Progression; Kidney Failure, Chronic; Kidney Function Tests; Lipids; Lipoproteins; Macrophages; Male; Mice; Mice, Knockout; Muscle Proteins; Nephrectomy; Oxidants; Oxidative Stress; Parathyroid Hormone; Peroxidase; Receptors, LDL; Tyrosine; Vasodilation | 2018 |
Microcrystalline Tyrosine and Aluminum as Adjuvants in Allergen-Specific Immunotherapy Protect from IgE-Mediated Reactivity in Mouse Models and Act Independently of Inflammasome and TLR Signaling.
Topics: Adjuvants, Immunologic; Aluminum Hydroxide; Animals; Desensitization, Immunologic; Disease Models, Animal; Hypersensitivity; Immunoglobulin E; Inflammasomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Signal Transduction; Toll-Like Receptors; Tyrosine | 2018 |
Lipopolysaccharide Induces Subacute Cerebral Microhemorrhages with Involvement of Nitric Oxide Synthase in Rats.
Topics: Animals; Brain; Capillary Permeability; Cerebral Hemorrhage; Disease Models, Animal; Inflammation; Isoenzymes; Lipopolysaccharides; Male; Microglia; Neuroimmunomodulation; Neurons; Nitric Oxide Synthase; Rats, Sprague-Dawley; Tyrosine | 2018 |
Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Humans; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotective Agents; Nitric Oxide Synthase Type II; Parkinson Disease, Secondary; Tyrosine | 2018 |
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Astrocytes; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; DNA Damage; Dopamine Plasma Membrane Transport Proteins; Inflammation; Mice, Inbred C57BL; Microglia; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitrosative Stress; Oxazoles; Oxidative Stress; Parkinson Disease; Poly Adenosine Diphosphate Ribose; Transcription Factor RelA; Tyrosine; Tyrosine 3-Monooxygenase | 2018 |
Endoplasmic reticulum stress induces spatial memory deficits by activating GSK-3.
Topics: Activating Transcription Factor 6; Alzheimer Disease; Animals; Brain; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Stress; Glycogen Synthase Kinase 3; Male; Membrane Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Serine; Spatial Memory; Tunicamycin; Tyrosine; Unfolded Protein Response | 2018 |
A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania.
Topics: Acute Disease; Amino Acids, Branched-Chain; Animals; Behavior, Animal; Bipolar Disorder; Caseins; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan; Tyrosine | 2018 |
Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Arterial Pressure; Biomarkers; Catalase; Disease Models, Animal; Epinephrine; Ethanol; Hypertension; Lipid Peroxidation; Male; NADPH Oxidases; Nebivolol; Nitric Oxide; Norepinephrine; Oxidative Stress; Rats, Wistar; Renin-Angiotensin System; Superoxide Dismutase; Sympathetic Nervous System; Tyrosine | 2018 |
LatY136F knock-in mouse model for human IgG4-related disease.
Topics: Adaptor Proteins, Signal Transducing; Adrenal Cortex Hormones; Animals; Disease Models, Animal; Gene Knock-In Techniques; Humans; Immunoglobulin G4-Related Disease; Kidney; Leukocytes, Mononuclear; Lung; Membrane Proteins; Mice; Mutation; Pancreas; Phenotype; Phenylalanine; Phosphoproteins; Salivary Glands; Tyrosine | 2018 |
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biomarkers; Cell Nucleus; Disease Models, Animal; Fibroblast Growth Factors; Healthy Volunteers; Hepatocytes; Humans; Intestinal Mucosa; Isoxazoles; Liver; Liver Cirrhosis, Biliary; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phosphorylation; Postprandial Period; Primary Cell Culture; Receptors, Cytoplasmic and Nuclear; Signal Transduction; src-Family Kinases; Tyrosine | 2018 |
Inhibition of GSK-3β on Behavioral Changes and Oxidative Stress in an Animal Model of Mania.
Topics: Aldehydes; Animals; Antioxidants; Behavior, Animal; Bipolar Disorder; Catalase; Dinoprost; Disease Models, Animal; Glutathione Peroxidase; Glycogen Synthase Kinase 3 beta; Lipid Peroxidation; Male; Motor Activity; Oxidative Stress; Protein Carbonylation; Rats, Wistar; Submitochondrial Particles; Superoxide Dismutase; Superoxides; Thiazoles; Tyrosine; Urea | 2019 |
L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy.
Topics: Actins; Animals; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Female; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Mutation; Myopathies, Nemaline; Tyrosine; Zebrafish | 2018 |
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Topics: Administration, Intravenous; Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Heterografts; Histocytochemistry; Luminescent Measurements; Neoplasm Transplantation; Rats; Surgery, Computer-Assisted; Treatment Outcome; Tyrosine | 2018 |
Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; CA1 Region, Hippocampal; Cytokines; Disease Models, Animal; Encephalitis; Humans; Lithium; Mice, Transgenic; Mutation; Plaque, Amyloid; Rats; Tyrosine | 2018 |
Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion.
Topics: Animals; Anthraquinones; Apoptosis; Brain; Brain Ischemia; Caspase 3; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitrosation; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Tyrosine | 2018 |
Selective peroxisome proliferator-activated receptor-α modulator K-877 regulates the expression of ATP-binding cassette transporter A1 in pancreatic beta cells.
Topics: Animals; ATP Binding Cassette Transporter 1; Benzoxazoles; Butyrates; Cell Line, Tumor; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Glucose; Glucose Intolerance; Humans; Hypolipidemic Agents; Insulin; Insulin-Secreting Cells; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Rats; RNA, Messenger; Tyrosine | 2018 |
IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.
Topics: Animals; Brain Injuries; Brain Ischemia; Cytokines; Disease Models, Animal; Inflammation; Interleukin-10; Interleukin-33; Interleukin-4; Lung; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Stroke; Th1 Cells; Th2 Cells; Treatment Outcome; Tyrosine | 2018 |
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins B-raf; Signal Transduction; Thyroid Carcinoma, Anaplastic; Thyroid Gland; Tyrosine | 2018 |
Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds.
Topics: 3T3 Cells; Adipocytes; Animals; Blood Glucose; Cell Line; Computer Simulation; Disease Models, Animal; Fatty Acid Transport Proteins; Glucose Tolerance Test; Glucose Transporter Type 4; Hyperglycemia; Hypoglycemic Agents; Mice; Molecular Docking Simulation; PPAR gamma; RNA, Messenger; Tyrosine | 2018 |
The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Isoenzymes; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine; Up-Regulation | 2018 |
Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats.
Topics: Animals; Autophagy; Beclin-1; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Lipids; Male; Myocytes, Cardiac; Nitrosative Stress; Obesity; Rats, Zucker; Sitagliptin Phosphate; Stroke Volume; Tyrosine; Ventricular Function, Left | 2018 |
Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3.
Topics: Administration, Oral; Albinism, Oculocutaneous; Animals; Blotting, Western; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Genotyping Techniques; Melanins; Melanosomes; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron, Transmission; Nitrobenzoates; Oxidoreductases; Real-Time Polymerase Chain Reaction; Treatment Outcome; Tyrosine | 2018 |
NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Male; Migraine Disorders; Neuronal Plasticity; Neurons; Pain; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Trigeminal Caudal Nucleus; Tyrosine | 2018 |
Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Female; Hippocampus; Humans; Induced Pluripotent Stem Cells; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neural Inhibition; Peptide Fragments; Synapses; Tyrosine | 2018 |
Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis.
Topics: Animals; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucosa; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Donors; Phosphorylation; RAW 264.7 Cells; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Toll-Like Receptor 4; Tyrosine | 2018 |
IL-6/YAP1/β-catenin signaling is involved in intervertebral disc degeneration.
Topics: Aggrecans; Animals; Apoptosis Regulatory Proteins; beta Catenin; Cells, Cultured; Collagen Type II; Disease Models, Animal; Interleukin-6; Intervertebral Disc Degeneration; Matrix Metalloproteinase 13; Nucleus Pulposus; Phosphorylation; Rats, Sprague-Dawley; Signal Transduction; SOX9 Transcription Factor; Tissue Culture Techniques; Tyrosine; Verteporfin; YAP-Signaling Proteins | 2019 |
Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.
Topics: Animals; Apolipoprotein A-II; Bezafibrate; Biometry; Blotting, Western; Butyrates; Clofibrate; Collagen Type I; Disease Models, Animal; Electroretinography; Fluorescent Antibody Technique, Indirect; Guinea Pigs; Intraocular Pressure; Malate Dehydrogenase; Myopia; Oxazoles; Phenylurea Compounds; PPAR alpha; Refraction, Ocular; Sensory Deprivation; Tyrosine | 2018 |
Hydromorphine postconditioning protects isolated rat heart against ischemia-reperfusion injury via activating P13K/Akt/eNOS signaling.
Topics: Animals; Creatine Kinase, MB Form; Disease Models, Animal; Isolated Heart Preparation; Male; Morphine Derivatives; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Troponin T; Tyrosine | 2018 |
A father's fight to help his sons - and fix clinical trials.
Topics: Adolescent; Alkaptonuria; Animals; Autopsy; Child; Clinical Trials as Topic; Compassionate Use Trials; Cyclohexanones; Disease Models, Animal; Disease Progression; Drug Approval; Endpoint Determination; Female; Homogentisic Acid; Humans; Infant; Male; Mice; National Health Programs; National Institutes of Health (U.S.); Nitrobenzoates; Observational Studies as Topic; Off-Label Use; Orphan Drug Production; Rare Diseases; Rats; Sample Size; Tyrosine; Tyrosinemias; United States; United States Food and Drug Administration | 2019 |
Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly.
Topics: Age Factors; Animals; Disease Models, Animal; Endothelial Cells; Liver; Male; Nitric Oxide; Phenotype; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Tyrosine | 2020 |
Gene Editing Successfully Corrects 2 Amino Acid Disorders: In 2 preclinical studies using CRISPR-mediated gene editing, phenylketonuria and hereditary tyrosinemia type 1 were corrected.
Topics: Amino Acids; Animals; CRISPR-Cas Systems; Disease Models, Animal; Gene Editing; Humans; Hydrolases; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Tyrosine; Tyrosinemias | 2019 |
Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System.
Topics: Amnesia; Animals; Dipeptides; Disease Models, Animal; Dopamine; Frontal Lobe; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Scopolamine; Tryptophan; Tyrosine | 2019 |
Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis.
Topics: Actins; Animals; Arthritis, Rheumatoid; Disease Models, Animal; Female; Humans; Malondialdehyde; Mice; Mice, Inbred C57BL; Molecular Dynamics Simulation; Muscle Contraction; Muscle Weakness; Muscle, Skeletal; Myosins; Oxidative Stress; Polymerization; Protein Processing, Post-Translational; Tyrosine | 2019 |
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels.
Topics: Adult; Animals; Chemokine CCL2; Disease Models, Animal; Epoprostenol; Fibrosis; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Kidney; Kidney Function Tests; Male; Mice, Inbred C57BL; Microvessels; Neovascularization, Physiologic; Regeneration; Transforming Growth Factor beta; Tyrosine; Uncoupling Protein 2; Ureteral Obstruction; Vascular Endothelial Growth Factor A | 2019 |
MicroRNA-140 inhibits skeletal muscle glycolysis and atrophy in endotoxin-induced sepsis in mice via the WNT signaling pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; beta Catenin; Cells, Cultured; Cytokines; Disease Models, Animal; Down-Regulation; Glycogen Synthase Kinase 3 beta; Glycolysis; Inflammation Mediators; Lactic Acid; Lipopolysaccharides; Male; Methylhistidines; Mice, Inbred BALB C; MicroRNAs; Muscle, Skeletal; Muscular Atrophy; Sepsis; Tyrosine; Wnt Proteins; Wnt Signaling Pathway | 2019 |
Technical feasibility of [
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Feasibility Studies; Female; Glioblastoma; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Dosage; Radiotherapy, Image-Guided; Rats, Inbred F344; Treatment Outcome; Tumor Burden; Tyrosine | 2019 |
The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats.
Topics: Action Potentials; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Male; Penicillins; Rats, Wistar; Running; Seizures; Tyrosine | 2019 |
Development of anti-chloro
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Apolipoprotein A-I; Atherosclerosis; Biomarkers; Coronary Artery Disease; Disease Models, Animal; Halogenation; Humans; Immunologic Tests; Lipoproteins, HDL; Mice, Knockout, ApoE; Oxidation-Reduction; Plaque, Atherosclerotic; Predictive Value of Tests; Reproducibility of Results; Tyrosine | 2019 |
MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.
Topics: Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Disease Models, Animal; Down-Regulation; Mice; Mice, Inbred C57BL; MicroRNAs; Oligonucleotide Array Sequence Analysis; Orexin Receptors; Oxidative Stress; Real-Time Polymerase Chain Reaction; Receptors, Neuropeptide; Retina; RNA, Messenger; Transfection; Tyrosine | 2013 |
A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Diet, Ketogenic; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Movement Disorders; Muscle, Skeletal; Presenilin-1; Reaction Time; Tyrosine | 2013 |
Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374).
Topics: Animals; Coenzyme A-Transferases; Diabetes Mellitus, Experimental; Disease Models, Animal; Energy Metabolism; Heart Diseases; Male; Metallothionein; Mice; Mice, Inbred Strains; Mice, Transgenic; Myocardium; Nitrogen; Protein Structure, Tertiary; Superoxides; Tryptophan; Tyrosine | 2013 |
Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone.
Topics: Aldehydes; Analysis of Variance; Animals; Blood-Brain Barrier; Cell Count; Disease Models, Animal; Hydrogen Peroxide; Locomotion; Male; Metalloporphyrins; Methylprednisolone; Microdialysis; Nervous System Diseases; Neuroprotective Agents; Oxidative Stress; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries; Time Factors; Tyrosine | 2013 |
EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee.
Topics: Aged; Animals; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Ginkgo biloba; Humans; Interleukin-1beta; Lipopolysaccharides; Male; Middle Aged; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis, Knee; Plant Extracts; Rats; Rats, Wistar; Toll-Like Receptor 4; Tyrosine | 2013 |
Nitration of Hsp90 induces cell death.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Disease Models, Animal; fas Receptor; HSP90 Heat-Shock Proteins; Humans; Motor Neurons; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Spinal Cord Injuries; Tyrosine | 2013 |
A tyrosine-to-histidine switch at position 18 of the Ross River virus E2 glycoprotein is a determinant of virus fitness in disparate hosts.
Topics: Alphavirus Infections; Amino Acid Substitution; Animals; Capsid Proteins; Cell Line; Culicidae; Disease Models, Animal; Histidine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Ross River virus; Tyrosine; Viral Envelope Proteins; Viral Load; Viremia; Virulence; Virulence Factors; Virus Replication | 2013 |
Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.
Topics: Animals; Cell Line; Cytokines; Disease Models, Animal; Gene Expression Profiling; Glucose Intolerance; I-kappa B Kinase; Inflammation Mediators; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Nephrectomy; NF-kappa B; Oligonucleotide Array Sequence Analysis; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Receptors, Immunologic; Renal Insufficiency, Chronic; RNA Interference; Signal Transduction; Time Factors; Transfection; Tyrosine | 2013 |
Dependence of vascular damage on higher frequency components in the rat-tail model.
Topics: Animals; Arteries; Disease Models, Animal; Hand-Arm Vibration Syndrome; Male; Rats; Rats, Sprague-Dawley; Tyrosine; Vacuoles; Vibration | 2013 |
The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fluoresceins; Glutamic Acid; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Neurotoxicity Syndromes; Neurotoxins; Nitric Oxide; Octreotide; Somatostatin; Tyrosine; Tyrosine 3-Monooxygenase | 2013 |
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.
Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Tyrosine | 2013 |
Chronic oxidative-nitrosative stress impairs coronary vasodilation in metabolic syndrome model rats.
Topics: Animals; Azoles; Coronary Vessels; Cyclic N-Oxides; Disease Models, Animal; Down-Regulation; Free Radical Scavengers; Guanylate Cyclase; Heart; Isoindoles; Male; Metabolic Syndrome; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrogen; Organoselenium Compounds; Oxidative Stress; Phosphorylation; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Spin Labels; Superoxides; Tyrosine; Vasodilation | 2013 |
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Axons; Dietary Supplements; Disease Models, Animal; Disease Progression; Eicosapentaenoic Acid; Female; Humans; Lipid Metabolism; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Motor Neurons; Mutant Proteins; Neuroglia; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Survival Analysis; Tyrosine; Vacuoles | 2013 |
Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor.
Topics: Animals; Antioxidants; Chronic Disease; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lipoproteins, LDL; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidases; Oxidative Stress; Pulmonary Artery; Reactive Oxygen Species; Scavenger Receptors, Class E; Signal Transduction; Tyrosine; Up-Regulation; Ventricular Function, Right; Ventricular Pressure | 2013 |
Therapeutic time window for edaravone treatment of traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain Injuries; Disease Models, Animal; Edaravone; Free Radical Scavengers; Japan; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2013 |
A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes.
Topics: Animals; Biomarkers; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Glutathione; Glutathione Peroxidase; Keratin-18; Liver; Male; Malondialdehyde; Mitochondria, Liver; Mitochondrial Proteins; Nitroso Compounds; Oxidative Phosphorylation; Oxidative Stress; Phospholipids; Rats; Rats, Wistar; Silybin; Silymarin; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances; Thioredoxins; Time Factors; Tyrosine; Vitamin E | 2013 |
Effects of balanced hydroxyethyl starch solutions on gut mucosal microcirculation and exhaled nitric oxide in septic rats: A randomised, animal study.
Topics: Animals; Arterioles; Capillaries; Disease Models, Animal; Erythrocytes; Hydroxyethyl Starch Derivatives; Inflammation; Intestines; Male; Microcirculation; Nitric Oxide; Oxidative Stress; Plasma Substitutes; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Solanum tuberosum; Tyrosine; Zea mays | 2013 |
Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.
Topics: Aged; Alcohol Oxidoreductases; Animals; Biopterins; Chromatography, High Pressure Liquid; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; GTP Cyclohydrolase; Humans; Hypertension, Pulmonary; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Pulmonary Fibrosis; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Tyrosine | 2013 |
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease.
Topics: Acute-Phase Proteins; Animals; Biomarkers; Chemokines; Cytokines; Deoxycytidine; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Female; Helicobacter hepaticus; Helicobacter Infections; Humans; Immunity, Innate; Inflammatory Bowel Diseases; Male; Mice; Mice, Knockout; Tyrosine | 2013 |
Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Inhalation; Aldehydes; Animals; Antioxidants; Cardiotonic Agents; Deoxyguanosine; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Gases; Hydrogen; Immunohistochemistry; Inhalation; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neutrophil Infiltration; Nitric Oxide; Oxidative Stress; Receptors, Cell Surface; Time Factors; Tyrosine; Ventricular Function, Left | 2013 |
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Topics: Aldehydes; Angiotensin II Type 1 Receptor Blockers; Animals; Catalase; Citrate (si)-Synthase; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Imidazoles; Insulin Resistance; Male; Membrane Glycoproteins; Mitochondria, Heart; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; NF-E2-Related Factor 2; Obesity; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Inbred OLETF; Receptor, Angiotensin, Type 1; RNA, Messenger; Signal Transduction; Succinate Dehydrogenase; Superoxide Dismutase; Tetrazoles; Time Factors; Tyrosine | 2013 |
Protective effect of tryptophan against dextran sulfate sodium- induced experimental colitis.
Topics: Animal Feed; Animals; Antidepressive Agents, Second-Generation; Body Weight; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Female; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress; Random Allocation; Tryptophan; Tyrosine | 2013 |
Inhibition of nitric oxide mediated protein nitration: therapeutic implications in experimental radiculopathy.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hindlimb; Hyperalgesia; Intervertebral Disc; Ligation; Nitric Oxide; Nitric Oxide Synthase; Proteins; Radiculopathy; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Transplantation, Autologous; Tyrosine | 2013 |
Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Blueberry Plants; Cell Proliferation; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, Animal; Drug Administration Schedule; Fruit; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Liver; Male; Necrosis; Oxidative Stress; Phytotherapy; Plant Extracts; Plants, Medicinal; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2013 |
NESS002ie: a new fluorinated thiol endopeptidase inhibitor with antinociceptive activity in an animal model of persistent pain.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Male; Mice; Naloxone; Pain, Intractable; Protease Inhibitors; Sulfhydryl Compounds; Tyrosine | 2013 |
Endogenous signal transducer and activator of transcription 3 is required for the protection of hepatocytes against warm ischemia/reperfusion injury.
Topics: Alanine Transaminase; Animals; Cell Proliferation; Cell Survival; Disease Models, Animal; Genotype; Hep G2 Cells; Hepatocytes; Humans; Ischemia; Liver; Liver Transplantation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Phosphorylation; Reperfusion Injury; STAT3 Transcription Factor; Tyrosine; Tyrphostins; Warm Ischemia | 2013 |
Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline.
Topics: Aging; Animals; Blotting, Western; Brain; Cognition Disorders; Diet; Disease Models, Animal; Isoelectric Focusing; Male; Mass Spectrometry; Nitrosation; Proteomics; Rats; Rats, Inbred F344; Tyrosine; Vitamin D Deficiency | 2013 |
Antioxidant properties of glutamine and its role in VEGF-Akt pathways in portal hypertension gastropathy.
Topics: Animals; Antioxidants; Disease Models, Animal; Esophageal and Gastric Varices; Glutamine; Glutathione; Hypertension, Portal; Male; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Stomach; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas.
Topics: Albumins; Animals; Brain Neoplasms; Contrast Media; Cyclic N-Oxides; Disease Models, Animal; Free Radicals; Gadolinium DTPA; Glioma; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Nitrogen Oxides; Oxidation-Reduction; Radiography; Spin Labels; Spin Trapping; Tumor Cells, Cultured; Tyrosine | 2013 |
In vivo PET/CT in a human glioblastoma chicken chorioallantoic membrane model: a new tool for oncology and radiotracer development.
Topics: Animals; Cell Line, Tumor; Chickens; Chorioallantoic Membrane; Disease Models, Animal; Drug Discovery; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glioblastoma; Glucose; Humans; Multimodal Imaging; Positron-Emission Tomography; Radioactive Tracers; Sodium Fluoride; Tomography, X-Ray Computed; Tumor Burden; Tyrosine | 2013 |
NADPH oxidase and nitric oxide synthase-dependent superoxide production is increased in proliferative lupus nephritis.
Topics: Adult; Animals; Biopsy; Blood Proteins; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Kidney Cortex; Lupus Nephritis; Male; Mice; Mice, Inbred MRL lpr; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Prospective Studies; Superoxides; Tyrosine; Up-Regulation; Young Adult | 2013 |
Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord contributes to chronic visceral pain in rats.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Excitatory Amino Acid Antagonists; Genistein; Irritable Bowel Syndrome; Male; Pain Measurement; Phenols; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Time Factors; Tyrosine; Visceral Pain | 2014 |
Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis.
Topics: Animals; Chemokines; Clostridioides difficile; Clostridium Infections; Colitis; Cytokines; Disease Models, Animal; Flow Cytometry; Genetic Predisposition to Disease; Intestinal Mucosa; Intestines; Leptin; Logistic Models; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Odds Ratio; Polymorphism, Genetic; Receptors, Leptin; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2014 |
Diverse effects of parenteral arginine on systemic and local oxidant-antioxidant homeostasis and nitrosative stress in rats with subacute peritonitis.
Topics: Animals; Antioxidants; Arginine; Disease Models, Animal; Energy Intake; Homeostasis; Infusions, Parenteral; Kidney; Lipid Peroxidation; Male; Nitric Oxide; Oxidants; Oxidative Stress; Peritonitis; Rats; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Severity of Illness Index; Tyrosine | 2014 |
Man made disease: clinical manifestations of low phenylalanine levels in an inadequately treated phenylketonuria patient and mouse study.
Topics: Alopecia; Animals; Body Weight; Corneal Perforation; Diarrhea, Infantile; Disease Models, Animal; Failure to Thrive; Female; Humans; Infant; Infant Formula; Male; Mice; Phenylalanine; Phenylketonurias; Random Allocation; Tyrosine; Vitamin A Deficiency | 2013 |
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
Topics: Animals; Caspase 3; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Lythraceae; Male; Mitochondrial Diseases; Nitric Oxide Synthase Type II; Oxidative Stress; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Tyrosine | 2014 |
Src64B phosphorylates Dumbfounded and regulates slit diaphragm dynamics: Drosophila as a model to study nephropathies.
Topics: Animals; Animals, Genetically Modified; Cell Aggregation; Cell Line; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Enzyme Activation; Glomerular Filtration Barrier; Humans; Kidney Diseases; Membrane Proteins; Microscopy, Electron, Transmission; Muscle Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Tyrosine | 2014 |
STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Animals; Apoptosis; beta Karyopherins; Cysteamine; Disease Models, Animal; Duodenal Ulcer; Duodenum; Early Growth Response Protein 1; Epirizole; Female; Gene Expression Regulation; Mice; Mice, Knockout; Oligodeoxyribonucleotides; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Time Factors; Tyrosine | 2014 |
Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA.
Topics: Acute Lung Injury; Amino Acid Sequence; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Endothelial Cells; Enzyme Activation; Humans; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred C57BL; Microvessels; Molecular Sequence Data; Nitric Oxide Synthase Type III; Nitrosation; Peptides; Protective Agents; rhoA GTP-Binding Protein; Tyrosine | 2014 |
Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease.
Topics: Adolescent; Adult; alpha-Galactosidase; Animals; Biomarkers; Case-Control Studies; Cell Line; Disease Models, Animal; Endothelial Cells; Fabry Disease; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type III; RNA, Small Interfering; Tyrosine; Vascular Diseases; Young Adult | 2014 |
Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction.
Topics: Animals; Antioxidants; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Movement; Disease Models, Animal; Lac Operon; Male; Mice; Mice, Transgenic; Myocardial Infarction; Myocytes, Cardiac; Reactive Nitrogen Species; Reactive Oxygen Species; Stem Cell Transplantation; Stem Cells; Time Factors; Tyrosine; Ventricular Remodeling | 2014 |
Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.
Topics: Adenosine Triphosphatases; Animals; Animals, Genetically Modified; Cells, Cultured; Cysteine; Disease Models, Animal; Drosophila; Drosophila Proteins; Female; Gene Expression Regulation; Green Fluorescent Proteins; Haploinsufficiency; Humans; Locomotion; Male; Microtubules; Mutation; Neurons; Nocodazole; Rats; Spastic Paraplegia, Hereditary; Spastin; Transfection; Tubulin Modulators; Tyrosine | 2014 |
Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Cell Death; Disease Models, Animal; Disease Progression; Lumbar Vertebrae; Male; Motor Activity; Motor Neurons; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Paralysis; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2014 |
Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Lactones; Male; Mice; NF-kappa B; Pleurisy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Sesquiterpenes; STAT3 Transcription Factor; Tyrosine | 2014 |
S-nitrosoglutathione inhibits inducible nitric oxide synthase upregulation by redox posttranslational modification in experimental diabetic retinopathy.
Topics: Analysis of Variance; Animals; Biomarkers; Cell Line; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Electroretinography; Glial Fibrillary Acidic Protein; Glutathione; Humans; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Ophthalmic Solutions; Rats; Reactive Oxygen Species; Retina; S-Nitrosoglutathione; Tyrosine; Up-Regulation | 2014 |
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.
Topics: Animals; Autocrine Communication; Brain Neoplasms; Capillary Permeability; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease Progression; Endothelial Cells; Female; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neoplasm Grading; Neovascularization, Pathologic; Phosphorylation; Profilins; RNA Interference; Time Factors; Transfection; Tumor Burden; Tumor Microenvironment; Tyrosine; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein | 2014 |
Blood-brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Claudin-5; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hemoglobins; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Up-Regulation; Zonula Occludens-1 Protein | 2014 |
Infiltrating neutrophils aggravate metabolic liver failure in fah-deficient mice.
Topics: Animals; Bilirubin; Body Weight; Cyclohexanones; Disease Models, Animal; Hepatocytes; Hydrolases; Inflammation; Interleukin-22; Interleukins; Liver; Liver Failure; Male; Mice; Mice, Knockout; Neutrophils; Nitrobenzoates; Receptors, CCR2; Tyrosine | 2015 |
Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum.
Topics: Animals; Antimalarials; Cytosol; Disease Models, Animal; Erythrocytes; Female; Flow Cytometry; Humans; Immunohistochemistry; Indoles; Malaria; Mice, Inbred C57BL; Plasmodium berghei; Plasmodium falciparum; Pyrroles; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Survival; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glutamate Plasma Membrane Transport Proteins; Humans; Male; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Tyrosine | 2014 |
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models, Animal; Erlotinib Hydrochloride; Female; Fibroblasts; Humans; Interleukin-6; Lung Neoplasms; Mice; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Serine; STAT3 Transcription Factor; Tyrosine | 2014 |
Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration.
Topics: Analysis of Variance; Animals; Chromatography, Liquid; Disease Models, Animal; Ectodysplasins; Ethidium; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Guanine; Microscopy, Electron, Transmission; Mitochondria; Myelin Basic Protein; Nerve Degeneration; Optic Nerve Injuries; Oxidative Stress; Rats; Reactive Oxygen Species; Tandem Mass Spectrometry; Time Factors; Tyrosine | 2014 |
Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Interleukin-8; Mycobacterium; Mycobacterium Infections; Myeloid Differentiation Factor 88; Neutrophils; Peroxidase; Reactive Nitrogen Species; Receptors, Interleukin-1; Receptors, Interleukin-8B; Signal Transduction; Toll-Like Receptors; Tyrosine; Zebrafish | 2014 |
Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice.
Topics: alpha-Tocopherol; Animals; Caspase 3; Cell Line; Cell Survival; Dietary Supplements; Disease Models, Animal; DNA-Binding Proteins; Lysosomes; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurodegenerative Diseases; Niemann-Pick Disease, Type C; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Proteins c-abl; Signal Transduction; Tumor Protein p73; Tumor Suppressor Proteins; Tyrosine; Vitamin E | 2014 |
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model.
Topics: 8-Hydroxy-2'-Deoxyguanosine; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Resorption; Cytokines; Deoxyguanosine; Disease Models, Animal; Gingiva; Inflammation; Male; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; Periodontitis; Random Allocation; Rats; Rats, Wistar; Resveratrol; Sirtuin 1; Stilbenes; Tyrosine | 2014 |
N-acetylcysteine administration confers lung protection in different phases of lung ischaemia-reperfusion injury.
Topics: Acetylcysteine; Administration, Intravenous; Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 3; Cytoprotection; Disease Models, Animal; Hemodynamics; I-kappa B Kinase; Inflammation Mediators; Interleukin-1beta; Lipid Peroxidation; Lung; Lung Injury; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Fluorescent Antibody Technique; Gene Knock-In Techniques; Hypoxia-Ischemia, Brain; Immunoprecipitation; Mice; Mice, Inbred C57BL; Oxidative Stress; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2014 |
Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.
Topics: Active Transport, Cell Nucleus; Animals; Antihypertensive Agents; Apoptosis; Becaplermin; Benzamides; Cell Adhesion; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paxillin; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; Signal Transduction; Time Factors; Transfection; Tyrosine; Vascular Remodeling | 2014 |
The characterization of neuroenergetic effects of chronic L-tyrosine administration in young rats: evidence for striatal susceptibility.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Citrate (si)-Synthase; Citric Acid Cycle; Corpus Striatum; Disease Models, Animal; Electron Transport Chain Complex Proteins; Energy Metabolism; Hippocampus; Malate Dehydrogenase; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; Tyrosine; Tyrosinemias | 2015 |
MicroRNA-23a-3p attenuates oxidative stress injury in a mouse model of focal cerebral ischemia-reperfusion.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Cell Line; Disease Models, Animal; Hydrogen Peroxide; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Mice, Inbred C57BL; MicroRNAs; Nitric Oxide; Oxidative Stress; Reperfusion Injury; Superoxide Dismutase; Transfection; Tyrosine; Up-Regulation | 2014 |
Characterization of diabetic neuropathy in the Zucker diabetic Sprague-Dawley rat: a new animal model for type 2 diabetes.
Topics: Age Factors; Animals; Arterioles; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Neuropathies; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Langerhans Cells; Male; Neural Conduction; Nociception; Rats, Sprague-Dawley; Rats, Zucker; Sciatic Nerve; Time Factors; Triglycerides; Tyrosine; Vasodilation | 2014 |
Inhibition of ocular aldose reductase by a new benzofuroxane derivative ameliorates rat endotoxic uveitis.
Topics: Aldehyde Reductase; Animals; Antioxidants; Apoptosis; Benzofurans; Disease Models, Animal; Enzyme Inhibitors; Eye; Inflammation Mediators; Lipopolysaccharides; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tyrosine; Ubiquitin; Uveitis | 2014 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morpholines; Naphthalenes; Oxazoles; Pentylenetetrazole; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Thiazolidinediones; Tyrosine | 2015 |
[Catecholamine content in the adrenal gland of rat offspring in the model of prenatal hyperhomocysteinemia].
Topics: Administration, Oral; Adrenal Glands; Animals; Animals, Newborn; Catecholamines; Disease Models, Animal; Female; Hyperhomocysteinemia; Methionine; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Tyrosine | 2014 |
The natural olive constituent oleuropein induces nutritional cardioprotection in normal and cholesterol-fed rabbits: comparison with preconditioning.
Topics: Animals; Cholesterol; Disease Models, Animal; Hypercholesterolemia; Iridoid Glucosides; Iridoids; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Olea; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protective Agents; Rabbits; Signal Transduction; Tyrosine | 2015 |
Trans-sodium crocetinate provides neuroprotection against cerebral ischemia and reperfusion in obese mice.
Topics: Aldehydes; Analysis of Variance; Animals; Brain; Brain Ischemia; Carotenoids; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Matrix Metalloproteinases; Mice; Nervous System Diseases; Neuroprotective Agents; Obesity; Oxidative Stress; Reperfusion; Tyrosine; Vitamin A | 2015 |
The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Benzenesulfonates; Beverages; Citrus; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; Mice; Neutrophil Infiltration; NF-kappa B; P-Selectin; Peroxidase; Plant Extracts; Poly Adenosine Diphosphate Ribose; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2015 |
Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma.
Topics: Animals; Apoptosis; Cell Respiration; Chemokines; Cytokines; Disease Models, Animal; Lung; Male; Mice, Inbred C57BL; Mitochondria, Muscle; Pulmonary Gas Exchange; Receptors, Purinergic; Respiratory Mechanics; Thoracic Injuries; Tyrosine; Wounds, Nonpenetrating | 2015 |
NR2B antagonist CP-101,606 inhibits NR2B phosphorylation at tyrosine-1472 and its interactions with Fyn in levodopa-induced dyskinesia rat model.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2015 |
Hippocampal Neuroprotection by Minocycline and Epigallo-Catechin-3-Gallate Against Cardiopulmonary Bypass-Associated Injury.
Topics: Adenosine Triphosphate; Animals; Apoptosis Inducing Factor; Brain Edema; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cardiopulmonary Bypass; Caspase 3; Catechin; Chromatography, High Pressure Liquid; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Minocycline; Neuroprotective Agents; Poly Adenosine Diphosphate Ribose; Swine; Tyrosine | 2015 |
Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Line; Cells, Cultured; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroimmunomodulation; Neuroprotective Agents; NF-kappa B; Phosphorylation; Rats, Sprague-Dawley; Tyrosine | 2015 |
Mechanisms of hyperhomocysteinemia induced skeletal muscle myopathy after ischemia in the CBS-/+ mouse model.
Topics: Animals; Antioxidants; Blotting, Western; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Mice, Inbred C57BL; Models, Biological; Muscle, Skeletal; Muscular Diseases; Nitric Oxide Donors; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Protein Binding; Transcription Factors; Tyrosine | 2015 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Acids; Fenofibrate; Flavonoids; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Myocytes, Cardiac; Oxazoles; Phenylephrine; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2015 |
Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice.
Topics: Angiotensin II; Animals; Catalase; Cytochrome P-450 CYP1B1; Disease Models, Animal; Drinking; Estradiol; Female; Fibrosis; Genotype; Hypertension; Kidney; Kidney Diseases; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Natriuresis; Oxidative Stress; Phenotype; Renin-Angiotensin System; Sex Factors; Superoxide Dismutase; Superoxides; Tyrosine; Urination | 2015 |
Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Down-Regulation; Female; Glycyrrhiza; Hyperglycemia; Inflammation; Isoflavones; Lipopolysaccharides; Liver; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phenols; Plant Roots; RNA, Messenger; Stress, Physiological; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2015 |
Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiomyopathies; Cyclooctanes; Disease Models, Animal; Doxorubicin; Gene Expression Regulation; Lignans; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Tyrosine; Ventricular Function, Left | 2015 |
Effect of the oestrogen receptor antagonist fulvestrant on the cirrhotic rat lung.
Topics: Animals; Cell Adhesion Molecules; Disease Models, Animal; Estradiol; Estrogen Receptor Antagonists; Fulvestrant; Heme Oxygenase (Decyclizing); Hepatopulmonary Syndrome; Liver Cirrhosis, Biliary; Lung; Macrophages; Male; Microfilament Proteins; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphoproteins; Phosphorylation; Rats, Wistar; Tyrosine; Vascular Endothelial Growth Factor A | 2015 |
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Topics: Amino Acid Motifs; Animals; Antigens, CD; B-Lymphocytes; Cell Death; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Activation; Female; Fusion Proteins, bcr-abl; Gene Deletion; Humans; Inositol Polyphosphate 5-Phosphatases; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Platelet Endothelial Cell Adhesion Molecule-1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Receptors, Immunologic; Signal Transduction; Syk Kinase; Tyrosine; Xenograft Model Antitumor Assays | 2015 |
The effects of tissue-non-specific alkaline phosphatase gene therapy on craniosynostosis and craniofacial morphology in the FGFR2C342Y/+ mouse model of Crouzon craniosynostosis.
Topics: Alkaline Phosphatase; Animals; Calcification, Physiologic; Calcium; Cephalometry; Cranial Sutures; Craniosynostoses; Cysteine; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors; Lentivirus; Male; Mice; Mice, Inbred BALB C; Occipital Bone; Parietal Bone; Phosphorus; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Skull; Tyrosine; X-Ray Microtomography | 2015 |
Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?
Topics: Administration, Intravenous; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Hemodynamics; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitrites; Protein Processing, Post-Translational; Sodium Nitrite; Superoxides; Tyrosine | 2015 |
Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Female; Flavonoids; Fruit; Humans; Ki-67 Antigen; Mammary Neoplasms, Experimental; MCF-7 Cells; Methylnitrosourea; Polyphenols; Rats; Stilbenes; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Endothelial Cells; Ethanolamines; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Lipopolysaccharides; Male; Malondialdehyde; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Palmitic Acids; Rats, Inbred Lew; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine; Uvea; Uveitis | 2015 |
The effects of n-acetylcysteine and/or deferoxamine on manic-like behavior and brain oxidative damage in mice submitted to the paradoxal sleep deprivation model of mania.
Topics: Acetylcysteine; Aldehydes; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Deferoxamine; Disease Models, Animal; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Sleep Deprivation; Tyrosine | 2015 |
The effects of tempol on cyclophosphamide-induced oxidative stress in rat micturition reflexes.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Calcitonin Gene-Related Peptide; Cyclic N-Oxides; Cyclophosphamide; Cystitis; Disease Models, Animal; Female; Oxidative Stress; Rats; Reactive Nitrogen Species; Reflex; Spin Labels; Substance P; Tyrosine; Urination | 2015 |
Protective effects of tirofiban on ischemia/reperfusion-induced renal injury in vivo and in vitro.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Blood Urea Nitrogen; Cell Line; Chemotaxis, Leukocyte; Creatinine; Cytoprotection; Disease Models, Animal; Kidney; Kidney Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Tirofiban; Tyrosine | 2015 |
Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Apoptosis; Cell Nucleus; Chymases; Cytokines; Disease Models, Animal; Disease Progression; Drug Interactions; Ethanolamines; Gene Expression Regulation; Kidney; Male; Mice; Nitrates; Nitrites; Oxidative Stress; Palmitic Acids; Reperfusion Injury; Risk Factors; Silymarin; Transcription Factor RelA; Tyrosine | 2015 |
Periapical Lesions Decrease Insulin Signaling in Rat Skeletal Muscle.
Topics: Animals; Blood Glucose; Blotting, Western; Cholesterol; Dental Pulp; Disease Models, Animal; Hyperlipidemias; Insulin; Insulin Receptor Substrate Proteins; Liver; Muscle, Skeletal; Phosphorylation; Rats, Wistar; Triglycerides; Tyrosine | 2015 |
A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase.
Topics: Amino Acyl-tRNA Synthetases; Animal Structures; Animals; Animals, Genetically Modified; Cell Nucleus; Cell Respiration; Disease Models, Animal; Drosophila melanogaster; Epistasis, Genetic; Flight, Animal; Genotype; Mitochondria, Muscle; Mitochondrial Diseases; Motor Activity; Muscles; Oxidative Phosphorylation; Peptide Chain Initiation, Translational; RNA, Transfer; Tyrosine | 2015 |
Oxidative stress in murine Theiler's virus-induced temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Glutathione; Glutathione Disulfide; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Theilovirus; Tyrosine | 2015 |
Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice.
Topics: Animals; Atrial Function, Left; Benzoxazines; Cannabinoid Receptor Agonists; Cardiotonic Agents; Cardiotoxicity; Cytoprotection; Disease Models, Animal; Doxorubicin; Heart Diseases; Male; Malondialdehyde; Mice, Inbred BALB C; Morpholines; Myocardial Contraction; Myocytes, Cardiac; Naphthalenes; Oxazoles; PPAR alpha; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
Topics: Animals; Cell Fractionation; Cells, Cultured; Cytokines; Disease Models, Animal; Encephalitis; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nitric Oxide; Oxidopamine; Parkinson Disease; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-fyn; Tumor Necrosis Factor-alpha; Tyrosine; Tyrosine 3-Monooxygenase | 2015 |
Galectin-3 Modulates Experimental Colitis.
Topics: Acute Disease; Animals; Benzamides; Chronic Disease; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Female; Fibroblasts; Galectin 3; Humans; Inflammation; Interleukin-10; Interleukin-4; Interleukin-6; Interleukin-8; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Tyrosine | 2015 |
A novel NAD(P)H-dependent carbonyl reductase specifically expressed in the thyroidectomized chicken fatty liver: catalytic properties and crystal structure.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Amino Acid Sequence; Amino Acid Substitution; Animals; Biocatalysis; Catalytic Domain; Chickens; Databases, Protein; Disease Models, Animal; Fatty Liver; Gene Expression Regulation, Enzymologic; Hypothyroidism; Liver; Molecular Sequence Data; Mutant Proteins; NADP; Phenanthrenes; Protein Conformation; Protein Stability; Protein Subunits; Recombinant Proteins; Tyrosine | 2015 |
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice.
Topics: Aldehydes; Allopurinol; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid; Xanthine Dehydrogenase | 2015 |
Angiotensin and mineralocorticoid receptor antagonism attenuates cardiac oxidative stress in angiotensin II-infused rats.
Topics: Adrenal Glands; Aldehydes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Eplerenone; Heart Diseases; Hypertension; Lipid Peroxidation; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Oxidative Stress; Rats, Sprague-Dawley; Renin-Angiotensin System; Signal Transduction; Spironolactone; Time Factors; Tyrosine | 2015 |
Tempol alleviates intracerebral hemorrhage-induced brain injury possibly by attenuating nitrative stress.
Topics: Animals; Antioxidants; Apoptosis; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Cerebral Hemorrhage; Collagenases; Cyclic N-Oxides; Disease Models, Animal; Male; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Spin Labels; Tyrosine; Zonula Occludens-1 Protein | 2015 |
Diet-induced obesity and kidney disease - In search of a susceptible mouse model.
Topics: Animals; Diet; Disease Models, Animal; Insulin Resistance; Lipid Metabolism; Male; Mice; Mitochondria; Nitric Oxide Synthase Type II; Obesity; Oxidative Stress; Renal Insufficiency, Chronic; Tyrosine | 2016 |
S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion.
Topics: Analysis of Variance; Animals; Brain; Brain Ischemia; Calpain; Chronic Disease; Cyclin-Dependent Kinase 5; Disease Models, Animal; Glycogen Synthase Kinase 3; Neuroprotective Agents; Phosphorylation; Rats; S-Nitrosoglutathione; Synaptosomes; tau Proteins; Tyrosine | 2015 |
Metallothionein expression in the rat brain following KA and PTZ treatment.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Metallothionein; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Tyrosine | 2015 |
Quantitative analysis of phenylalanine, tyrosine, tryptophan and kynurenine in rat model for tauopathies by ultra-high performance liquid chromatography with fluorescence and mass spectrometry detection.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Kynurenine; Phenylalanine; Rats; Rats, Inbred SHR; Rats, Transgenic; Tandem Mass Spectrometry; Tauopathies; Tryptophan; Tyrosine | 2016 |
Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Apoptosis; Disease Models, Animal; Eukaryotic Translation Initiation Factor 5A; Golgi Apparatus; Humans; Hypoxia; Male; Models, Biological; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Oxygen; Peptide Fragments; Peptide Initiation Factors; Protein Transport; Rats; RNA-Binding Proteins; Signal Transduction; trans-Golgi Network; Tyrosine | 2015 |
Role of thioredoxin nitration in bleomycin-induced pulmonary fibrosis in rats.
Topics: Animals; Bleomycin; Disease Models, Animal; Humans; Hydroxyproline; Idiopathic Pulmonary Fibrosis; Lung; Male; Nitrates; Oxidation-Reduction; Pulmonary Fibrosis; Rats; Rats, Wistar; Thioredoxins; Tyrosine | 2016 |
Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats.
Topics: Animals; Blood Pressure; Body Weight; Creatinine; Disease Models, Animal; Endothelium, Vascular; Erythropoietin; Femoral Artery; Heart Rate; Hemoglobins; Kidney Function Tests; Male; NADPH Oxidase 4; NADPH Oxidases; Nephrectomy; Nitric Oxide Synthase Type III; Nitroglycerin; Polyethylene Glycols; Proteinuria; Rats; Renal Insufficiency, Chronic; Tyrosine; Ultrasonography; Vasodilation | 2015 |
The effects of repetitive vibration on sensorineural function: biomarkers of sensorineural injury in an animal model of metabolic syndrome.
Topics: Animals; Biophysics; Chemokine CCL2; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Interleukin-1beta; Male; Metabolic Syndrome; Neuralgia; Nitric Oxide Synthase Type I; Rats; Rats, Zucker; Receptors, Adrenergic, alpha-2; RNA, Messenger; Time Factors; Transcutaneous Electric Nerve Stimulation; Tyrosine; Vibration | 2015 |
Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus.
Topics: Altitude Sickness; Animals; Antioxidants; Caspase 3; Disease Models, Animal; Hippocampus; Hypoxia; Male; Melatonin; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Tyrosine | 2015 |
Imaging of deep venous thrombosis using radioactive-labeled tirofiban.
Topics: Animals; Disease Models, Animal; Male; Platelet Glycoprotein GPIIb-IIIa Complex; Radionuclide Imaging; Rats; Rats, Wistar; Technetium; Tirofiban; Tyrosine; Venous Thrombosis | 2015 |
Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Cholesterol; Diet, High-Fat; Disease Models, Animal; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glyceryl Ethers; Inflammation Mediators; Lysophospholipids; Male; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Oxidation-Reduction; Oxidative Stress; Plaque, Atherosclerotic; Plasmalogens; Tyrosine; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2015 |
Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Cytochrome P-450 CYP1A2; Deoxyguanosine; Diet; Disease Models, Animal; Humans; Imidazoles; Ki-67 Antigen; Male; Mice, Transgenic; NF-E2-Related Factor 2; Phosphorylation; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Tocopherols; Tyrosine | 2016 |
N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats.
Topics: Acetylcysteine; Animals; Antioxidants; Blotting, Western; Comet Assay; Disease Models, Animal; DNA Damage; Gastric Mucosa; Hypertension, Portal; Immunohistochemistry; Male; Neovascularization, Pathologic; Nitric Oxide Synthase Type III; Portal Pressure; Rats, Wistar; Stomach; Tyrosine; Vascular Endothelial Growth Factor A; Vasodilation | 2015 |
Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury.
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Gene Deletion; Humans; Kidney; Membrane Proteins; Mice, Inbred C57BL; Molecular Sequence Data; Nephritis; Phosphorylation; Podocytes; Protamines; Protein Interaction Maps; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Tyrosine | 2016 |
Reproducibility of O-(2-(18)F-fluoroethyl)-L-tyrosine uptake kinetics in brain tumors and influence of corticoid therapy: an experimental study in rat gliomas.
Topics: Animals; Biological Transport; Brain Neoplasms; Dexamethasone; Disease Models, Animal; Glioma; Kinetics; Male; Positron-Emission Tomography; Rats; Reproducibility of Results; Tyrosine | 2016 |
Intraventricular apolipoprotein ApoJ infusion acts protectively in Traumatic Brain Injury.
Topics: Aldehydes; Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cerebral Cortex; Clusterin; Disease Models, Animal; Infusions, Intraventricular; Male; Mice, Inbred C57BL; Neuroprotective Agents; Tyrosine | 2016 |
Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Biomarkers; Cell Proliferation; Disease Models, Animal; Doxorubicin; Energy Metabolism; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucose; Humans; Mice; Mitochondria; Myocytes, Cardiac; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Pyrimidines; Reactive Oxygen Species; Tyrosine; Up-Regulation | 2015 |
Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Echocardiography; Female; Interleukin-10; Interleukin-6; Mice, Inbred C57BL; Myocardium; Nitric Oxide Synthase Type II; Nitrites; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-β1 Signaling Pathway in Sprague-Dawley Rats Model.
Topics: Animals; Antioxidants; Body Weight; Catalase; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutathione Peroxidase; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; MAP Kinase Signaling System; Mass Spectrometry; Organ Size; Oxidation-Reduction; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Sus scrofa; Transforming Growth Factor beta1; Tyrosine | 2016 |
An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability.
Topics: Animals; Blotting, Western; Brain; Cytosol; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Intellectual Disability; Isoenzymes; Lipopolysaccharides; Mice, Knockout; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tissue Culture Techniques; Transcription Factor RelA; Tyrosine | 2016 |
RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Disease Models, Animal; Female; Hypochlorous Acid; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Pneumonia; Pulmonary Fibrosis; rho-Associated Kinases; Scleroderma, Systemic; Skin; Smad2 Protein; Smad3 Protein; Tyrosine | 2016 |
Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies.
Topics: Adult; Aged; Animals; Brain Neoplasms; Case-Control Studies; Cell Line, Tumor; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Glioblastoma; Glutamic Acid; Heterografts; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tomography, X-Ray Computed; Tyrosine | 2016 |
Regulation of Coronary Endothelial Function by Interactions between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice.
Topics: Adiponectin; Animals; Antibodies, Neutralizing; Apolipoproteins E; Arterioles; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Genetic Predisposition to Disease; Male; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Phenotype; Scavenger Receptors, Class E; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Vasodilation; Vasodilator Agents | 2015 |
A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammation.
Topics: Active Transport, Cell Nucleus; Administration, Oral; Amides; Animals; Carrageenan; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Drug Compounding; Drug Interactions; Edema; Ethanolamines; Gene Expression Regulation, Enzymologic; Glucosides; Hyperalgesia; Inflammation; Male; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Palmitic Acids; Proteolysis; Rats; Rats, Sprague-Dawley; Stilbenes; Superoxide Dismutase; Transcription Factor RelA; Tyrosine | 2016 |
The memory enhancement effect of Kai Xin San on cognitive deficit induced by simulated weightlessness in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcholinesterase; Animals; Avoidance Learning; Brain; Choline O-Acetyltransferase; Cognition Disorders; Deoxyguanosine; Disease Models, Animal; Drugs, Chinese Herbal; Escape Reaction; Hindlimb Suspension; Male; Memory; Neuroprotective Agents; Phytotherapy; Rats, Sprague-Dawley; Reactive Oxygen Species; Swimming; Tyrosine; Weightlessness | 2016 |
Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction.
Topics: Animals; Arginase; Disease Models, Animal; Female; Fetal Growth Retardation; Heme Oxygenase-1; Kidney; Kidney Glomerulus; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Placental Circulation; Pregnancy; Rabbits; Reactive Oxygen Species; RNA, Messenger; Transcriptome; Tyrosine | 2016 |
PTEN inhibition preserves trigeminal nucleus caudalis neuron activation through tyrosine phosphorylation of the NR2B subunit at Tyr1472 of the NMDA receptor in a rat model of recurrent migraine.
Topics: Adenoviridae; Animals; Disease Models, Animal; Gene Expression Regulation; Male; Migraine Disorders; Neurons; Pain Measurement; Pain Threshold; Phosphopyruvate Hydratase; Phosphorylation; Proto-Oncogene Proteins c-fos; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; RNA, Small Interfering; Trigeminal Nuclei; Tyrosine | 2016 |
Effects of Early Post-Ischemic Reperfusion and tPA on Cerebrovascular Function and Nitrosative Stress in Female Rats.
Topics: Actins; Amides; Animals; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Middle Cerebral Artery; Muscle, Smooth; Neutrophils; Ovariectomy; Pyridines; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Tissue Plasminogen Activator; Tyrosine | 2016 |
Dityrosine as a marker of acute myocardial infarction? Experiments with the isolated Langendorff heart.
Topics: Animals; Biomarkers; Disease Models, Animal; Immunohistochemistry; Isolated Heart Preparation; Myocardial Infarction; Myocardium; Rats, Wistar; Tyrosine | 2016 |
Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine.
Topics: Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Halogenation; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Mice; Oxidation-Reduction; Peroxidase; Phenanthridines; Tandem Mass Spectrometry; Tyrosine; Vascular Diseases | 2016 |
Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Immunohistochemistry; Infrared Rays; Mice; Microscopy, Confocal; Neurodegenerative Diseases; Oxidative Stress; Phototherapy; Random Allocation; Rats; Spinal Cord; Spinal Cord Injuries; Tissue Culture Techniques; Tyrosine | 2016 |
Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Febuxostat; Hypertension; Male; Oxidative Stress; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2016 |
Tyrosine phosphorylation of RACK1 triggers cardiomyocyte hypertrophy by regulating the interaction between p300 and GATA4.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Cell Enlargement; Cells, Cultured; Disease Models, Animal; E1A-Associated p300 Protein; GATA4 Transcription Factor; Gene Knockdown Techniques; HEK293 Cells; Humans; Male; Myocytes, Cardiac; Neoplasm Proteins; Phenylephrine; Phosphorylation; Protein Binding; Rats; Rats, Inbred Dahl; Receptors for Activated C Kinase; Tetrazoles; Transcription, Genetic; Tyrosine | 2016 |
[Effect of Resveratrol Preconditioning on Myocardial Dysfunction after Cardiac Arrest in Rats].
Topics: Animals; Disease Models, Animal; Heart; Heart Arrest; Ischemic Preconditioning; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Tyrosine | 2016 |
Tyrosinemia type I and not treatment with NTBC causes slower learning and altered behavior in mice.
Topics: Animals; Behavior, Animal; Cyclohexanones; Disease Models, Animal; Hydrolases; Learning; Memory, Long-Term; Mice; Nitrobenzoates; Tyrosine; Tyrosinemias | 2016 |
Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antigens, CD; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Fumarates; Gene Expression Regulation; Humans; Maleates; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinsonian Disorders; Rats; Signal Transduction; Tyrosine | 2016 |
Treatment with synthetic lipophilic tyrosyl ester controls Leishmania major infection by reducing parasite load in BALB/c mice.
Topics: Animals; Antiprotozoal Agents; Cytokines; Disease Models, Animal; Immunologic Factors; Injections, Subcutaneous; Leishmania major; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Parasite Load; Th1 Cells; Tyrosine | 2016 |
Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.
Topics: alpha-Synuclein; Animals; Brain Infarction; Brain Ischemia; Caspase 3; Death-Associated Protein Kinases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Motor Activity; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; RNA, Small Interfering; Stroke; Tyrosine | 2016 |
Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model.
Topics: Animals; Animals, Newborn; Asphyxia; Biomarkers; Brain; Disease Models, Animal; Female; Ischemic Postconditioning; Neuroglia; Nitric Oxide Synthase; Oxidative Stress; Sus scrofa; Tyrosine | 2016 |
Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.
Topics: Adolescent; Animals; Carcinoma, Hepatocellular; Catalytic Domain; Cell Line, Tumor; Child; Child, Preschool; Disease Models, Animal; Female; Heptanoates; Humans; Hydrolases; Infant; Liver Cirrhosis; Liver Neoplasms; Male; Mice; Mutation, Missense; Pedigree; Sequence Analysis, DNA; Tyrosine; Tyrosinemias | 2016 |
In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound.
Topics: Animals; Anti-Bacterial Agents; Aquatic Organisms; Biological Products; Cell Line; Disease Models, Animal; Disulfides; Epithelial Cells; Female; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Tyrosine; Vibrio Infections; Vibrio vulnificus | 2016 |
Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Dependovirus; Disease Models, Animal; Electroretinography; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; Intraocular Pressure; Mutation; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Transduction, Genetic; Tyrosine | 2016 |
Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Proliferation; Chlorocebus aethiops; COS Cells; Disease Models, Animal; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Recurrence, Local; Oligonucleotide Array Sequence Analysis; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src Homology Domains; Tyrosine; Ubiquitination | 2016 |
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Hippocampus; Mice, Transgenic; Microelectrodes; Mitochondria; Neurotransmitter Agents; Nitric Oxide; Oxidative Phosphorylation; Oxygen Consumption; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tyrosine | 2016 |
A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains.
Topics: Amino Acid Substitution; Animals; Antimicrobial Cationic Peptides; Bacterial Proteins; Cathelicidins; Cell Line; Cysteine; Disease Models, Animal; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Phenotype; Point Mutation; Protein Binding; Protein Kinases; Staphylococcal Skin Infections; Tyrosine; Viral Tropism | 2016 |
Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats.
Topics: Animals; Brain; Cell Line, Tumor; Choline; Diagnosis, Differential; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Glioblastoma; Humans; Kinetics; Necrosis; Neoplasm Grading; Positron-Emission Tomography; Radiation Injuries; Radiopharmaceuticals; Rats, Inbred F344; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2016 |
Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy.
Topics: Animals; Biomarkers; Disease Models, Animal; Dogs; Inflammation; Macrophages; Male; Muscle Proteins; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Neutrophils; Oxidation-Reduction; Oxidative Stress; Peroxidase; Tyrosine | 2016 |
Neuroprotective effects of methane-rich saline on experimental acute carbon monoxide toxicity.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Carbon Monoxide Poisoning; Carboxyhemoglobin; Cell Count; Cytokines; Deoxyguanosine; Disease Models, Animal; Hippocampus; Male; Malondialdehyde; Methane; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Superoxide Dismutase; Time Factors; Tyrosine | 2016 |
Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Cells, Cultured; Cisplatin; Cochlea; Disease Models, Animal; Down-Regulation; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; LIM Domain Proteins; Manganese Compounds; Membrane Proteins; Mice; Mice, Inbred CBA; Peroxynitrous Acid; Serpins; Signal Transduction; Tyrosine | 2016 |
Antidepressant-like effect of pramipexole in an inflammatory model of depression.
Topics: Animals; Benzothiazoles; Brain; Depression; Disease Models, Animal; Dopamine Agonists; Female; Glial Fibrillary Acidic Protein; Illness Behavior; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Locomotion; Malondialdehyde; Mice; Pramipexole; Swimming; Time Factors; Tyrosine | 2017 |
The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Fenofibrate; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatitis; Hepatocytes; Humans; Hypolipidemic Agents; Inflammation Mediators; Lipids; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Oxazoles; Plant Extracts; PPAR alpha; Rats, Inbred OLETF; RNA, Messenger; Transfection; Tyrosine | 2017 |
1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia.
Topics: Animals; Annexin A5; Apoptosis; Cells, Cultured; Cognition Disorders; Disease Models, Animal; Gene Expression Regulation; Hypoxia; Imines; Lipid Peroxidation; Malondialdehyde; Maze Learning; Microglia; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Oxygen; Rats; Rats, Sprague-Dawley; Tyrosine | 2017 |
A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin
Topics: Abciximab; Animals; Antibodies, Monoclonal; Cardiovascular Diseases; Disease Models, Animal; Eptifibatide; Fibrinogen; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Integrin alpha2; Integrin beta3; Mice; Naphthalenes; Peptides; Platelet Aggregation; Rats; Thrombocytopenia; Thrombosis; Tirofiban; Tyrosine | 2016 |
Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gene Knockdown Techniques; Humans; Interleukin-6; Mice; Mutation; Neoplasm Metastasis; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Tumor Burden; Tyrosine | 2017 |
Topics: Adult; Animals; Calcium Channels, L-Type; Calcium Signaling; Calcium-Binding Proteins; Cardiomyopathies; Case-Control Studies; Disease Models, Animal; Female; Genetic Predisposition to Disease; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Phenotype; Potassium Channels, Inwardly Rectifying; Reactive Nitrogen Species; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2017 |
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Benzamides; Bridged Bicyclo Compounds; Cocaine; Conditioning, Operant; Disease Models, Animal; Fenofibrate; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Oxazoles; PPAR alpha; Pyrimidines; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2017 |
Nitration of TRPM2 as a Molecular Switch Induces Autophagy During Brain Pericyte Injury.
Topics: Animals; Autophagy; Blood-Brain Barrier; Brain Injuries; Cells, Cultured; Disease Models, Animal; Gene Knockout Techniques; Humans; Mice; Microtubule-Associated Proteins; Nanoparticles; Nitrosative Stress; Pericytes; TRPM Cation Channels; Tyrosine; Zinc Oxide | 2017 |
Comparative assessment of 6-[
Topics: Animals; Apomorphine; Aromatic-L-Amino-Acid Decarboxylases; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Fluorine Radioisotopes; Image Processing, Computer-Assisted; Male; Neostriatum; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Stereotyped Behavior; Tyrosine | 2017 |
Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Body Weight; Deoxyguanosine; Disease Models, Animal; Inflammation; Insulin; Lipids; Lipoproteins, LDL; Metabolic Syndrome; Oxidative Stress; Peroxidase; Rats; Rats, Inbred SHR; Tyrosine; Ubiquinone | 2008 |
Lack of IFN-gamma synthesis in aqueous humor during corneal graft rejection correlates with suppressed nitric oxide production by macrophages.
Topics: Animals; Aqueous Humor; Corneal Transplantation; Disease Models, Animal; Female; Flow Cytometry; Graft Rejection; Interferon-gamma; Interleukin-10; Macrophages; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy.
Topics: Amyloid Neuropathies, Familial; Animals; Apoptosis; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; fas Receptor; Gastrointestinal Tract; Heat-Shock Proteins; Humans; Immunohistochemistry; Methionine; Mice; Mice, Transgenic; Molecular Chaperones; Mutant Proteins; Mutation; Oxidation-Reduction; Prealbumin; Protein Structure, Quaternary; Taurochenodeoxycholic Acid; Thermodynamics; Tyrosine | 2008 |
Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury.
Topics: Amidines; Animals; Benzylamines; Blood Pressure; Chemokines; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fluid Therapy; Glutathione Transferase; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Adhesion Molecule-1; Isoenzymes; Liver; Liver Diseases; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Tyrosine; Wounds and Injuries | 2008 |
Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cardiotonic Agents; Cell Nucleus; Decanoic Acids; Disease Models, Animal; Drug Antagonism; Hydroxy Acids; Male; Malondialdehyde; Muscle Proteins; Myocardial Reperfusion Injury; Neutrophils; Phosphorylation; Rats; Rats, Wistar; Sulfides; Tyrosine | 2009 |
Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.
Topics: Animals; Brain; Cardiopulmonary Bypass; Cardiopulmonary Resuscitation; Disease Models, Animal; Heart Arrest; Hypothermia, Induced; Male; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2008 |
Estrogen administration attenuates bladder outlet obstruction induced oxidative stress in the female rabbit.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Carbachol; Choline O-Acetyltransferase; Cholinergic Agonists; Disease Models, Animal; Drug Administration Schedule; Electric Stimulation; Estradiol; Estrogens; Female; Injections, Subcutaneous; Muscle Contraction; Oxidative Stress; Potassium Chloride; Protein Carbonylation; Rabbits; Superoxide Dismutase; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2009 |
Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage.
Topics: Analysis of Variance; Animals; Brain Edema; Calcium-Binding Proteins; Cerebral Hemorrhage; Cytochromes c; Disease Models, Animal; Encephalitis; Fluoresceins; Functional Laterality; Glial Fibrillary Acidic Protein; Granulocyte Colony-Stimulating Factor; Heme Oxygenase (Decyclizing); Interleukin-3; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Nerve Degeneration; Organic Chemicals; Recombinant Fusion Proteins; Recombinant Proteins; Spectrophotometry; Time Factors; Tyrosine | 2008 |
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia.
Topics: Aldehydes; Angiotensin II; Animals; Antioxidants; Arterioles; Body Weight; Cyclic N-Oxides; Disease Models, Animal; Glomerular Filtration Rate; Hypertension, Renal; Hyperuricemia; Kidney Glomerulus; Male; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Oxonic Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Spin Labels; Superoxides; Tyrosine | 2008 |
Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury.
Topics: 2,4-Dinitrophenol; Aldehydes; Animals; Antioxidants; Cell Respiration; Cyclic N-Oxides; Disease Models, Animal; Electron Transport Complex I; Energy Metabolism; Female; Mitochondria; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Spin Labels; Spinal Cord Diseases; Time Factors; Tyrosine; Uncoupling Agents | 2009 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine | 2008 |
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
Topics: Animals; Arginase; Boronic Acids; Bronchi; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Activation; Female; Inflammation Mediators; Metaplasia; Mice; Mice, Inbred BALB C; Mucus; Nitrates; Nitric Oxide; Nitrosation; Proteins; Respiratory Hypersensitivity; Tyrosine; Up-Regulation | 2008 |
Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Erythrocytes; Hemoglobins; Liver; Lung; Male; Rats; Rats, Wistar; Resuscitation; Shock, Hemorrhagic; Tyrosine | 2009 |
Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Injections, Intraperitoneal; Male; Microglia; Neuroprotective Agents; Nicotine; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2009 |
Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome.
Topics: Animals; Aorta, Abdominal; Apoptosis; Carotid Artery Injuries; Cell Cycle; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA Replication; Dose-Response Relationship, Drug; Hyperplasia; Male; Metabolic Syndrome; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Proline; Rats; Rats, Zucker; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Triazenes; Tyrosine | 2008 |
Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion.
Topics: Acute Disease; Animals; Antioxidants; Apoptosis; Calbindin 2; Disease Models, Animal; In Situ Nick-End Labeling; Lutein; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oxidative Stress; Poly Adenosine Diphosphate Ribose; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; S100 Calcium Binding Protein G; Tyrosine | 2009 |
Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Fas Ligand Protein; Gene Expression Regulation; Humans; Inflammation; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylation; Pyruvates; Spinal Cord Injuries; Time Factors; Tyrosine | 2009 |
Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cisplatin; Disease Models, Animal; Free Radical Scavengers; Glutathione; Kidney; Kidney Diseases; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Tyrosine | 2009 |
Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model.
Topics: Amino Acids; Animals; Blotting, Western; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intra-Abdominal Fat; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Inbred F344; RNA, Messenger; Tyrosine | 2010 |
Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Cell Culture Techniques; Disease Models, Animal; Gene Expression; Gene Expression Regulation; Humans; Immunoblotting; Lipopolysaccharides; Mice; Mice, Transgenic; Phosphoglycerate Kinase; Protein Processing, Post-Translational; Receptors, Urokinase Plasminogen Activator; Respiratory Mucosa; RNA, Messenger; Tyrosine | 2009 |
Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Deoxyguanosine; Diabetes Mellitus; Diabetic Nephropathies; Dinoprost; Disease Models, Animal; Hydralazine; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Tetrazoles; Treatment Outcome; Tyrosine | 2009 |
Loss of Purkinje cells in the PKCgamma H101Y transgenic mouse.
Topics: Amino Acid Substitution; Animals; Caspase 12; Connexins; Disease Models, Animal; Enzyme Activation; Histidine; Humans; Mice; Mice, Transgenic; Phosphorylation; Protein Kinase C; Purkinje Cells; Spinocerebellar Ataxias; Tyrosine | 2009 |
16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Bleomycin; Body Weight; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, Animal; Infusions, Subcutaneous; Interleukin-1beta; Lung; Lung Injury; Male; Mice; Peroxidase; Pneumonia; Protective Agents; Pulmonary Edema; Pulmonary Fibrosis; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia.
Topics: Animals; Chondrodysplasia Punctata; Disease Models, Animal; Enzyme Activation; Hearing Loss; Heterozygote; Labyrinth Diseases; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Mutation; Receptor, Fibroblast Growth Factor, Type 3; Tyrosine | 2009 |
Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome.
Topics: Animals; Cell Line, Transformed; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Galectin 1; Humans; Kidney; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Immunoelectron; Mitogen-Activated Protein Kinase 3; Nephrosis, Lipoid; Phosphorylation; Podocytes; Rats; Recombinant Proteins; Tyrosine | 2009 |
Tirofiban increases soluble guanylate cyclase in rat vascular walls: pharmacological and pathophysiological consequences.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Hypertension; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tachyphylaxis; Time Factors; Tirofiban; Tyrosine; Up-Regulation; Vasodilation; Vasodilator Agents | 2009 |
Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS' role in disease.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Inflammation; Nitric Oxide Synthase Type II; Osteoarthritis; Rats; Severity of Illness Index; Tyrosine | 2009 |
NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart.
Topics: Acetophenones; Acetylcholine; Aldehydes; Animals; Antioxidants; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Heart Failure; Hemodynamics; Male; NADPH Oxidases; Oxidative Stress; RNA, Messenger; Superoxides; Tyrosine; Up-Regulation; Vasodilation; Vasodilator Agents | 2009 |
B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging.
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Carotid Arteries; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Femoral Artery; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Superoxides; Tyrosine; Vascular Resistance; Vasodilation; Vasodilator Agents | 2009 |
Lactobacillus fermentum CECT 5716 prevents and reverts intestinal damage on TNBS-induced colitis in mice.
Topics: Animals; Colitis; Colony Count, Microbial; Cytokines; Disease Models, Animal; Eicosanoids; Immunoenzyme Techniques; Intestinal Mucosa; Limosilactobacillus fermentum; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88; Peroxidase; Probiotics; Trinitrobenzenesulfonic Acid; Tyrosine | 2009 |
Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Middle Aged; Monocytes; Proteomics; Rats; Tyrosine | 2009 |
Growth factors outside the PDGF family drive experimental PVR.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cell Culture Techniques; Collagen Type I; Conjunctiva; Disease Models, Animal; Epiretinal Membrane; Fibroblasts; Humans; Intercellular Signaling Peptides and Proteins; Mice; Phosphorylation; Platelet-Derived Growth Factor; Rabbits; Receptor, Platelet-Derived Growth Factor alpha; Recombinant Fusion Proteins; Tyrosine; Vitrectomy; Vitreoretinopathy, Proliferative; Vitreous Body | 2009 |
Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism.
Topics: Aldehydes; Aldosterone; Amlodipine; Animals; Calcium; Calcium Channel Blockers; Chronic Disease; Disease Models, Animal; Glutathione Peroxidase; Homeostasis; Hydrogen Peroxide; Hyperaldosteronism; Male; Metallothionein; Mineralocorticoid Receptor Antagonists; Mitochondria, Heart; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone; Superoxide Dismutase; Tyrosine; Zinc | 2009 |
Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma.
Topics: Animals; Apoptosis; Disease Models, Animal; Edema; Immunohistochemistry; Inflammation; Male; Mice; Neutrophil Infiltration; Oxidative Stress; Plant Extracts; Poly(ADP-ribose) Polymerases; Spinal Cord Injuries; Tea; Time Factors; Tyrosine | 2009 |
Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cytochromes c; Disease Models, Animal; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Mutation; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Superoxide Dismutase; Tyrosine; Ubiquitin | 2009 |
PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fluorine Radioisotopes; Genetic Vectors; Male; Nerve Degeneration; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics; tau Proteins; Time Factors; Transfection; Tyrosine | 2009 |
PPAR-alpha modulate the anti-inflammatory effect of glucocorticoids in the secondary damage in experimental spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Dexamethasone; Disease Models, Animal; Inflammation Mediators; Interleukin-1beta; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide Synthase Type II; PPAR alpha; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cytokines; Disease Models, Animal; Immunoenzyme Techniques; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Mice; Motor Activity; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances; Tyrosine | 2009 |
Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antioxidants; Apoptosis; Collagen; Disease Models, Animal; Disease Progression; Fibrosis; Glucosephosphate Dehydrogenase; HSP47 Heat-Shock Proteins; Hydrogen Peroxide; Ischemia; Kidney; Lipid Peroxidation; Male; Metalloporphyrins; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Oxidative Stress; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Reperfusion Injury; S100 Calcium-Binding Protein A4; S100 Proteins; Superoxide Dismutase; Time Factors; Tyrosine; Vitamin E | 2009 |
Oxidative stress related changes in the brain of hypercholesterolemic rabbits.
Topics: Animals; Brain; Cholesterol; Disease Models, Animal; Hypercholesterolemia; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Proteasome Endopeptidase Complex; Protein Carbonylation; Rabbits; Tyrosine; Vitamin E | 2008 |
Tyrosine: a possible marker of severe intestinal injury during ischemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Intestinal Mucosa; Intestines; Ischemia; Lactates; Male; Rabbits; Regional Blood Flow; Reperfusion Injury; Tyrosine | 2009 |
Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Autophagy; Disease Models, Animal; Down-Regulation; Endoplasmic Reticulum; Humans; Insulin Resistance; Leupeptins; Mice; Mice, Inbred Strains; Obesity; Phosphorylation; Receptor, Insulin; Taurochenodeoxycholic Acid; Tyrosine | 2009 |
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.
Topics: Animals; Blotting, Western; Cell Count; Cell Culture Techniques; Cell Death; Computational Biology; Disease Models, Animal; Drosophila; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Fluorescence; Forkhead Box Protein O3; Forkhead Transcription Factors; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred C57BL; Motor Neuron Disease; Motor Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Tyrosine | 2009 |
Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Glutathione; Glutathione Disulfide; Hyperglycemia; Male; Mice; Mice, Inbred Strains; Microcirculation; Myocardium; Oxidants; Oxidation-Reduction; Specific Pathogen-Free Organisms; Stroke Volume; Tyrosine; Vascular Endothelial Growth Factor A; Ventricular Function, Left | 2009 |
Neuroprotective effects of N-stearoyltyrosine on transient global cerebral ischemia in gerbils.
Topics: Animals; Disease Models, Animal; Female; Gerbillinae; Ischemic Attack, Transient; Male; Neuroprotective Agents; Oxidative Stress; Tyrosine | 2009 |
Disruption of an env tyrosine-dependent sorting signal does not affect susceptibility of HIV-1 to cytotoxic T lymphocytes.
Topics: Animals; Disease Models, Animal; env Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV-1; Macaca; T-Lymphocytes, Cytotoxic; Tyrosine | 2009 |
Molecular alterations associated with aneurysmal remodeling are localized in the high hemodynamic stress region of a created carotid bifurcation.
Topics: Analysis of Variance; Animals; Carotid Artery, Common; Disease Models, Animal; Dogs; Female; Gene Expression Regulation; Hemodynamics; Intracranial Aneurysm; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Stress, Mechanical; Time Factors; Tyrosine | 2009 |
Aged garlic extract delays the appearance of infarct area in a cerebral ischemia model, an effect likely conditioned by the cellular antioxidant systems.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Garlic; Glutathione Peroxidase; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Tyrosine | 2010 |
Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air).
Topics: Animals; Animals, Newborn; Apoferritins; Carbon Monoxide Poisoning; Cerebellum; Disease Models, Animal; Embryo, Mammalian; Female; Heme Oxygenase-1; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Catalytic Domain; Central Nervous System; Disease Models, Animal; Disease Progression; Facial Nerve; Gene Expression Regulation; Hepatocyte Growth Factor; Humans; Mice; Mice, Transgenic; Motor Neurons; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-met; Rhombencephalon; Serine; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; CD40 Antigens; Disease Models, Animal; Female; Humans; Immunoprecipitation; Male; Matrix Metalloproteinase 9; Maze Learning; Mice; Mice, Transgenic; Minocycline; Nerve Growth Factor; Nerve Growth Factors; Nitric Oxide Synthase Type II; Peptide Fragments; Peroxynitrous Acid; Protein Precursors; Rats; Rats, Inbred F344; Reaction Time; Tyrosine; Up-Regulation | 2009 |
Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Disease Models, Animal; Ethanolamines; Hypertension, Renal; NADPH Oxidases; Nebivolol; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Podocytes; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Reactive Oxygen Species; Renin; Renin-Angiotensin System; Tyrosine | 2009 |
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.
Topics: Animals; Arterioles; Biomarkers; Chemokine CCL2; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; I-kappa B Proteins; Inflammation Mediators; Macrophages; Male; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Receptors, Leptin; Serine; Signal Transduction; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2009 |
Thalidomide suppresses sclerosing encapsulating peritonitis in a rat experimental model.
Topics: Animals; Anti-Infective Agents; Blotting, Western; Chlorhexidine; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation; I-kappa B Proteins; Immunohistochemistry; Immunosuppressive Agents; NF-kappa B; Nitric Oxide Synthase Type II; Peritonitis; Peroxidase; Poly Adenosine Diphosphate Ribose; Rats; Thalidomide; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A | 2009 |
Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite.
Topics: Animals; Biomarkers; Cholesterol, Dietary; Disease Models, Animal; Hyperlipidemias; Male; Metalloporphyrins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Rats; Signal Transduction; Stress, Physiological; Tyrosine | 2009 |
In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography.
Topics: Amino Acid Sequence; Animals; Blood Proteins; Cattle; Cell Extracts; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Disease Models, Animal; Humans; Jurkat Cells; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidation-Reduction; Peptides; Proteome; Proteomics; Salmonella; Serum Albumin, Bovine; Shock, Septic; Tetranitromethane; Thiosulfates; Tyrosine | 2009 |
Role of neutrophils in arginine-asymmetric dimethylarginine pathway subsequent to endotoxemia.
Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Liver; Male; Neutrophils; Peroxidase; Tyrosine | 2009 |
Supplementary catechins attenuate cooking-oil-fumes-induced oxidative stress in rat lung.
Topics: Acute Lung Injury; Aldehydes; Animals; Apoptosis; bcl-2-Associated X Protein; Catechin; Cooking; Dietary Supplements; Disease Models, Animal; Female; HSP70 Heat-Shock Proteins; Oils; Oxidative Stress; Pneumonia; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors; Tyrosine | 2009 |
Superoxide signaling in pain is independent of nitric oxide signaling.
Topics: Animals; Antimycin A; Cyclic N-Oxides; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neuralgia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain Measurement; Peroxynitrous Acid; Reactive Oxygen Species; Signal Transduction; Spin Labels; Superoxides; Tyrosine | 2009 |
Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice.
Topics: Acute Lung Injury; Animals; Animals, Newborn; Arachidonate 5-Lipoxygenase; Coenzyme A; Cyclooxygenase 2; Disease Models, Animal; Glutathione Disulfide; Hydroxyeicosatetraenoic Acids; Hyperoxia; Liver; Lung; Mice; Mice, Inbred C3H; Oxidative Stress; Prostaglandins; Time Factors; Tyrosine | 2010 |
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Catechin; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Glutathione; Hyperoxia; Hypoxia; Ischemia; Lipid Peroxidation; Metalloporphyrins; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Protective Agents; Retinal Neovascularization; Retinal Vessels; Tyrosine | 2010 |
Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.
Topics: Animals; Cell Line; Depression; Disease Models, Animal; Down-Regulation; Gene Knock-In Techniques; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenylalanine; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tyrosine | 2009 |
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Humans; Neurons; Parkinson Disease; Phosphorylation; Serine; Tyrosine | 2009 |
Neuroprotective effects of tempol on retinal ganglion cells in a partial optic nerve crush rat model with and without iron load.
Topics: Animals; Antioxidants; Cell Count; Cell Survival; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Hematinics; Immunoenzyme Techniques; Iron Overload; Iron-Dextran Complex; Neuroprotective Agents; Optic Nerve Injuries; Oxidative Stress; Rats; Rats, Inbred BN; Retinal Degeneration; Retinal Ganglion Cells; Spin Labels; Tyrosine | 2010 |
Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Cytokines; Disease Models, Animal; Fas Ligand Protein; Hydrocarbons, Fluorinated; In Situ Nick-End Labeling; Laminectomy; Lipid Peroxidation; Liver X Receptors; Male; Mice; Movement Disorders; Myelitis; Neutrophil Infiltration; NF-kappa B; Nitric Oxide Synthase Type II; Orphan Nuclear Receptors; Peroxidase; Poly Adenosine Diphosphate Ribose; Proteins; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Statistics, Nonparametric; Sulfonamides; Time Factors; Tyrosine | 2010 |
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.
Topics: alpha-Synuclein; Animals; Caspase 3; CD11b Antigen; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Electrochemistry; Encephalitis; Gene Expression Regulation; Male; Mitochondria; Neurodegenerative Diseases; Oxidative Stress; Rats; Rats, Inbred F344; Rotarod Performance Test; Solvents; Substantia Nigra; Trichloroethylene; Tyrosine; Tyrosine 3-Monooxygenase | 2010 |
Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruzi.
Topics: Animals; Cells, Cultured; Chagas Disease; Disease Models, Animal; Female; Host-Parasite Interactions; Immunity, Innate; Inflammation Mediators; Interferon-gamma; Interleukin-12 Subunit p40; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelitis; Nerve Degeneration; Nerve Growth Factors; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Paraplegia; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Spinal Cord; Trypanosoma cruzi; Tyrosine | 2010 |
Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid.
Topics: Aldehydes; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Down-Regulation; Electron Transport Complex I; Energy Metabolism; Epilepsy; Excitatory Amino Acid Agonists; Free Radical Scavengers; Homocysteine; Male; Metabolic Networks and Pathways; Mitochondria; Mitochondrial Diseases; Oxidative Stress; Rats; Rats, Wistar; Seizures; Survival Rate; Time Factors; Tyrosine | 2010 |
The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Bridged Bicyclo Compounds; Disease Models, Animal; Encephalitis; Glial Fibrillary Acidic Protein; Gliosis; Humans; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Oxidative Stress; Phloroglucinol; Terpenes; Tyrosine | 2010 |
Antioxidant therapy reverses impaired graft healing in hypercholesterolemic rabbits.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta, Abdominal; Blood Vessel Prosthesis Implantation; Cell Movement; Cell Proliferation; Cholesterol; Disease Models, Animal; Endothelial Cells; Hypercholesterolemia; Hyperplasia; Macrophages; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Rabbits; Thiobarbituric Acid Reactive Substances; Tyrosine; Wound Healing | 2010 |
Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.
Topics: Aconitate Hydratase; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Detergents; Disease Models, Animal; Disease Progression; Electrophoresis, Gel, Two-Dimensional; Humans; Immunohistochemistry; Mice; NG-Nitroarginine Methyl Ester; Protein Structure, Quaternary; Proteins; Proteomics; Reproducibility of Results; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spinal Cord; Stress, Physiological; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.
Topics: Acoustic Stimulation; Adenosine; Adenosine A1 Receptor Agonists; Animals; Auditory Threshold; Cochlea; Cochlear Microphonic Potentials; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, Noise-Induced; Male; Oxidative Stress; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Time Factors; Tyrosine | 2010 |
Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Lipid Peroxidation; Male; Melatonin; Neural Conduction; Niacinamide; Pain Measurement; Pain Threshold; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Streptozocin; Tyrosine; Vitamin B Complex | 2010 |
Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Inflammation Mediators; Ketamine; Male; Nociceptors; Pain, Postoperative; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Remifentanil; Spinal Cord; Synaptic Transmission; Tyrosine | 2009 |
Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Encephalitis; Female; Galectin 3; Gliosis; Hypoxia-Ischemia, Brain; Inflammation Mediators; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Degeneration; Tyrosine | 2010 |
Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures.
Topics: Analysis of Variance; Animals; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Cathepsin D; Cytochromes c; Deoxyribonucleases; Disease Models, Animal; Electroencephalography; Epilepsy, Generalized; Epoxy Compounds; Glycoside Hydrolases; Lithium; Lysosomes; Male; Mitochondria; Neurons; Pilocarpine; Protein Transport; Rats; Rats, Wistar; Tyrosine | 2010 |
Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior.
Topics: Age Factors; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Anxiety; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Gene Expression Regulation; Humans; Hyperkinesis; Maze Learning; Mice; Mice, Transgenic; Motor Activity; Mutation; Norepinephrine; Serotonin Plasma Membrane Transport Proteins; Tyrosine | 2010 |
Interneuronal transfer of human tau between Lamprey central neurons in situ.
Topics: Animals; Cell Line, Tumor; Central Nervous System; Dendrites; Disease Models, Animal; Green Fluorescent Proteins; Humans; Lampreys; Mice; Mutation; Neuroblastoma; Neurofilament Proteins; Neurons; Phosphorylation; Protein Transport; tau Proteins; Tauopathies; Transduction, Genetic; Tyrosine | 2010 |
The effect of tyrosine nitration of L-type Ca2+ channels on excitation-transcription coupling in colonic inflammation.
Topics: Animals; Blotting, Western; Calcium Channels, L-Type; CHO Cells; Colitis; Cricetinae; Cricetulus; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Excitation Contraction Coupling; Humans; Immunohistochemistry; Immunoprecipitation; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth; Patch-Clamp Techniques; Peroxynitrous Acid; Protein Kinase Inhibitors; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; src-Family Kinases; Transcriptional Activation; Transfection; Tyrosine | 2010 |
Cold exposure exacerbates the development of diabetic polyneuropathy in the rat.
Topics: Animals; Blood Glucose; Cold Temperature; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; H-Reflex; Male; Motor Neurons; Neural Conduction; Rats; Sensory Receptor Cells; Skin; Streptozocin; Tyrosine | 2009 |
Hypercapnia attenuates hypoxic pulmonary hypertension by inhibiting lung radical injury.
Topics: Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Hypercapnia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung Injury; Male; Oxidative Stress; Pulmonary Artery; Rats; Rats, Wistar; Time Factors; Tyrosine | 2009 |
Oxidative stress contributes to methamphetamine-induced left ventricular dysfunction.
Topics: Actin Cytoskeleton; Animals; Antioxidants; Cardiac Catheterization; Cyclic N-Oxides; Disease Models, Animal; Male; Methamphetamine; Mitochondrial Proteins; Myocardial Contraction; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2010 |
Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degeneration.
Topics: Aldehydes; Animals; Choroidal Neovascularization; Coloring Agents; Disease Models, Animal; Female; Fluorescein Angiography; Indocyanine Green; Light; Oxidative Stress; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Rats, Wistar; Retina; Retinal Degeneration; Tomography, Optical Coherence; Tyrosine | 2010 |
Glycogen synthase kinase 3β and its phosphorylated form (Y216) in the paraquat-induced model of parkinsonism.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mesencephalon; Motor Activity; Paraquat; Parkinsonian Disorders; Phosphorylation; Rats; Rats, Wistar; Substantia Nigra; Tyrosine | 2011 |
Neuroprotective effects of NSTyr on cognitive function and neuronal plasticity in rats of chronic cerebral hypoperfusion.
Topics: Animals; Cerebrovascular Disorders; Chronic Disease; Cognition; Disease Models, Animal; GAP-43 Protein; Hippocampus; Long-Term Potentiation; Maze Learning; Memory Disorders; Microtubule-Associated Proteins; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Space Perception; Synaptophysin; Tyrosine | 2010 |
IL-2 and IFN-gamma in the retina of diabetic rats.
Topics: Animals; Cataract; Chemokines; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Interferon-gamma; Interleukin-10; Interleukin-1alpha; Interleukin-1beta; Interleukin-2; Interleukin-4; Interleukin-6; Interleukin-8; Male; Nitric Oxide; Rats; Rats, Long-Evans; Retina; T-Lymphocytes, Helper-Inducer; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCD.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Ion Channel Gating; Kidney Cortex; Kidney Tubules, Collecting; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Phosphorylation; Potassium Deficiency; Potassium, Dietary; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Small-Conductance Calcium-Activated Potassium Channels; src-Family Kinases; Superoxides; Tyrosine | 2010 |
Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Drug Combinations; Fluid Therapy; Goats; Hemodynamics; Inflammation; Infusions, Intravenous; Isotonic Solutions; Lactates; Leukocyte Count; Male; Myocardium; Neutrophils; Oxidative Stress; Pyruvic Acid; Resuscitation; Ringer's Lactate; Shock, Hemorrhagic; Treatment Outcome; Tyrosine | 2010 |
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
Topics: Allergens; Animals; Antigens, Dermatophagoides; Arginase; Arginine; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Tyrosine | 2010 |
Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression.
Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Experimental; Cartilage; Collagen Type II; Cytokines; Disease Models, Animal; Edema; Female; Ginsenosides; Hyperplasia; Inflammation; Interleukin-1beta; Joint Capsule; Joints; Lipopolysaccharides; Male; Malondialdehyde; Matrix Metalloproteinase 3; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Oxidative Stress; Panax; Phytotherapy; Plant Extracts; Plant Roots; Spleen; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism.
Topics: Animals; Cardiotonic Agents; Cell Line; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hemodynamics; Ligands; Lipopeptides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neutrophil Infiltration; Peptidoglycan; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Time Factors; Toll-Like Receptor 2; Tyrosine; Ventricular Function | 2010 |
Oligomerized Abeta25-35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Disks Large Homolog 4 Protein; Enzyme Activation; Feedback, Physiological; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Neurons; Peptide Fragments; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Synaptic Transmission; Tyrosine; Up-Regulation | 2010 |
Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Caspase 3; Cell Death; Disease Models, Animal; Humans; Luciferases; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Growth Factor; Neurons; Nitric Oxide Synthase Type II; PC12 Cells; Peptide Fragments; Phosphorylation; Presenilin-1; Rats; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Time Factors; Transfection; TYK2 Kinase; Tyrosine | 2010 |
Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice.
Topics: Animals; Calcium Signaling; Catalase; Cells, Cultured; Cysteine; Disease Models, Animal; Down-Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; Mice; Mice, Transgenic; Myocardial Contraction; Myocytes, Cardiac; Oxidation-Reduction; Protein Processing, Post-Translational; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine; Up-Regulation; Ventricular Dysfunction, Left | 2010 |
Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes.
Topics: Animals; Antioxidants; Cell Respiration; Diabetes Mellitus, Type 2; Disease Models, Animal; Electron Transport; Electron Transport Chain Complex Proteins; Ion Channels; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria, Heart; Mitochondrial ADP, ATP Translocases; Mitochondrial Proteins; Mitochondrial Proton-Translocating ATPases; Mitochondrial Size; Oxidative Stress; Protein Processing, Post-Translational; Proteome; Proteomics; Tyrosine; Uncoupling Protein 3 | 2010 |
Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Interleukin-8; Lung; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Poly Adenosine Diphosphate Ribose; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Sheep; Time Factors; Tyrosine | 2010 |
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Disease Progression; Fluorescent Antibody Technique; Humans; Mice; Mice, Transgenic; Microscopy, Confocal; Microscopy, Immunoelectron; Phosphorylation; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-fyn; src-Family Kinases; tau Proteins; Tauopathies; Tyrosine | 2010 |
Therapeutic liver reconstitution with murine cells isolated long after death.
Topics: Animals; Biomarkers; Cadaver; Cell Proliferation; Cell Separation; Cell Survival; Cells, Cultured; Disease Models, Animal; Hepatocytes; Humans; Hydrolases; Liver; Liver Regeneration; Macaca mulatta; Mice; Mice, Knockout; Proteins; RNA, Untranslated; Temperature; Time Factors; Tyrosine; Tyrosinemias | 2010 |
Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Coumaric Acids; Disease Models, Animal; Free Radical Scavengers; Gene Expression Regulation; Male; Neuroprotective Agents; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reperfusion Injury; Tyrosine | 2010 |
Melatonin reduces hyperalgesia associated with inflammation.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melatonin; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Signal Transduction; Superoxides; Tyrosine | 2010 |
Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers.
Topics: Animals; Blood Glucose; Blood Pressure; Cells, Cultured; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Humans; Kidney Glomerulus; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NADPH Oxidase 4; NADPH Oxidases; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Smoking; Tyrosine | 2010 |
Sex differences in nitrosative stress during renal ischemia.
Topics: Acute Kidney Injury; Animals; Antioxidants; Disease Models, Animal; Enzyme Activation; Female; Glomerular Filtration Rate; Kidney Medulla; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Multimerization; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reperfusion Injury; Sex Factors; Sulfhydryl Compounds; Time Factors; Tyrosine | 2010 |
New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
Topics: Animals; Biopterins; Breath Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Heterozygote; Mice; Mice, Mutant Strains; Mutation; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Treatment Outcome; Tyrosine | 2010 |
Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Tyrosine; Vascular Resistance; Ventricular Dysfunction, Right | 2010 |
Efficacy of treatment with verbascoside, biotechnologically produced by Syringa vulgaris plant cell cultures in an experimental mice model of spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Culture Techniques; Chromatography, High Pressure Liquid; Disease Models, Animal; Glucosides; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Interleukin-1beta; Male; Mice; Mice, Inbred Strains; Motor Activity; Nitric Oxide Synthase Type II; Phenols; Plant Extracts; Poly Adenosine Diphosphate Ribose; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Spinal Cord; Spinal Cord Injuries; Syringa; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Topics: Animals; Blood Pressure; Brain; Caspase 3; Disease Models, Animal; Endothelin-1; Epilepsy; Heart Rate; Hydrocarbons, Brominated; Infarction, Middle Cerebral Artery; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Stroke; Tyrosine | 2011 |
D-18F-fluoromethyl tyrosine imaging of bone metastases in a mouse model.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Mice; Mice, Nude; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2010 |
The nitric oxide donor molsidomine rescues cardiac function in rats with chronic kidney disease and cardiac dysfunction.
Topics: Administration, Oral; Animals; Biomarkers; Cardiotonic Agents; Creatinine; Disease Models, Animal; Gene Expression Regulation; Kidney Diseases; Male; Molsidomine; Myocardial Contraction; Myocardium; Nephrectomy; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Rats; Rats, Inbred Lew; Stroke Volume; Time Factors; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2010 |
Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Heart; Hypertension; Kidney; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Periodontitis; Peroxidase; Radiography; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Neuroprotective effects of almond skins in experimental spinal cord injury.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Inflammation; Lipid Peroxidation; Male; Mice; Neuroprotective Agents; Neutrophil Infiltration; NF-kappa B; Plant Extracts; Plant Structures; Prunus; Spinal Cord Injuries; Tyrosine | 2011 |
Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation.
Topics: Alveolar Bone Loss; Animals; Antioxidants; Camellia sinensis; Catechin; Connective Tissue; Dentifrices; Disease Models, Animal; Epithelial Attachment; Gingiva; Gingival Recession; Lipid Peroxidation; Lysine; Male; NF-kappa B; Oxidative Stress; Periodontitis; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Cardiopulmonary effects of low-dose arginine vasopressin in ovine acute lung injury.
Topics: Acute Lung Injury; Animals; Arginine Vasopressin; Cardiac Output; Central Venous Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemodynamics; Oxygen Consumption; Pulmonary Gas Exchange; Random Allocation; Reference Values; Sheep; Sheep, Domestic; Smoke Inhalation Injury; Stroke Volume; Tyrosine; Vascular Resistance; Vasoconstrictor Agents | 2011 |
Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury.
Topics: Animals; Burns; Capillary Permeability; Catalysis; Disease Models, Animal; Female; Hemodynamics; Interleukin-8; Lung; Metalloporphyrins; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Pulmonary Circulation; Sheep; Smoke Inhalation Injury; Tyrosine; Vascular Endothelial Growth Factor A | 2011 |
Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Flurbiprofen; Humans; Inflammation; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidoreductases; Parkinson Disease; Rotarod Performance Test; Substantia Nigra; Tyrosine | 2010 |
Effects of Hypericum Perforatum, in a rodent model of periodontitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cytokines; Disease Models, Animal; Edema; Flavonoids; Hypericum; Inflammation Mediators; Male; Mouth Mucosa; Neutrophil Infiltration; Periodontitis; Phenols; Phytotherapy; Plant Extracts; Poly(ADP-ribose) Polymerases; Polyphenols; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.
Topics: Allopurinol; Animals; Aorta; Arginine; Benzbromarone; Biological Transport; Blood Pressure; Cationic Amino Acid Transporter 1; Disease Models, Animal; Hyperuricemia; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxonic Acid; Phosphorylation; Protein Kinase C-alpha; Rats; Rats, Wistar; Tyrosine; Uric Acid; Uricosuric Agents | 2011 |
Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats.
Topics: Acetophenones; Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Cytochromes c; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; NADPH Oxidases; Neurologic Examination; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2011 |
Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome.
Topics: Animals; Aorta; Arginine; Blood Glucose; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fructose; Heart Rate; Hypertension; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2011 |
Nitration of the egg-allergen ovalbumin enhances protein allergenicity but reduces the risk for oral sensitization in a murine model of food allergy.
Topics: Air Pollution; Allergens; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Epitopes; Female; Food Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Inflammation; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Nitrogen; Ovalbumin; Smog; Tandem Mass Spectrometry; Tyrosine | 2010 |
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease.
Topics: Acetylcysteine; Animals; Benzamides; Brain; Case-Control Studies; Cell Line; Disease Models, Animal; Dopamine; Drug Administration Schedule; Free Radical Scavengers; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Imatinib Mesylate; Immunoprecipitation; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; MPTP Poisoning; Oxidative Stress; Peptide Elongation Factors; Phosphorylation; Piperazines; Polyethylene Glycols; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; RNA, Small Interfering; Statistics, Nonparametric; Transfection; Tumor Suppressor Proteins; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination | 2011 |
Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-κB reporter mice prior to loss of dopaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Astrocytes; Cell Death; Coculture Techniques; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Hindlimb; Inflammation; Male; Mice; Mice, Transgenic; Motor Activity; Neurons; Neurotoxins; NF-kappaB-Inducing Kinase; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2011 |
Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma.
Topics: Analysis of Variance; Animals; Burns; Disease Models, Animal; Female; Imidazoles; Immunohistochemistry; Interleukin-8; Lung; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Piperazines; Pulmonary Gas Exchange; Pyrimidines; RNA, Messenger; Sheep; Smoke Inhalation Injury; Tyrosine | 2011 |
Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; Endothelium, Vascular; Hepatocyte Growth Factor; Hindlimb; Ischemia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Skeletal; Neovascularization, Physiologic; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Recovery of Function; Regional Blood Flow; Signal Transduction; Time Factors; Tyrosine | 2011 |
Poly(ADP-ribose) polymerase-1: a novel therapeutic target in necrotizing enterocolitis.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Enterocolitis, Necrotizing; Enzyme Activation; Enzyme Inhibitors; Humans; Infant, Newborn; Intestinal Mucosa; Intestines; Niacinamide; Nitric Oxide; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tyrosine | 2011 |
The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Disease Models, Animal; Hydrolysis; Intercellular Adhesion Molecule-1; Interleukin-1beta; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Lung; Male; Mice; Nitric Oxide; Olive Oil; P-Selectin; Phenols; Plant Oils; Pleurisy; Poly Adenosine Diphosphate Ribose; Pyrans; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Heparin versus tirofiban in microvascular anastomosis: randomized controlled trial in a rat model.
Topics: Anastomosis, Surgical; Animals; Disease Models, Animal; Drug Therapy, Combination; Fascia; Fibrinolytic Agents; Follow-Up Studies; Free Tissue Flaps; Head and Neck Neoplasms; Heparin; Microsurgery; Neoplasms, Experimental; Plastic Surgery Procedures; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Rats; Rats, Sprague-Dawley; Skin Transplantation; Therapeutic Irrigation; Thrombosis; Tirofiban; Treatment Outcome; Tyrosine; Wound Healing | 2011 |
A micro-PET/CT approach using O-(2-[18F]fluoroethyl)-L-tyrosine in an experimental animal model of F98 glioma for BNCT.
Topics: Animals; Boron Neutron Capture Therapy; Brain Neoplasms; Disease Models, Animal; Glioma; Multimodal Imaging; Positron-Emission Tomography; Rats; Tomography, X-Ray Computed; Tyrosine | 2011 |
Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis.
Topics: Adrenomedullin; Animals; Anti-Inflammatory Agents; Bleomycin; Cell Adhesion Molecules; Cytokines; Disease Models, Animal; Inflammation Mediators; Injections, Intraperitoneal; Lung; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Peroxidase; Pneumonia; Poly(ADP-ribose) Polymerases; Pulmonary Fibrosis; Severity of Illness Index; Time Factors; Transforming Growth Factor beta; Tyrosine | 2011 |
Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Fibrosis; Granulocyte Colony-Stimulating Factor; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iron; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocarditis; Simvastatin; Thrombosis; Tirofiban; Tyrosine | 2011 |
Andrographolide inhibits PI3K/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia-induced oxidative brain injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cerebral Infarction; Disease Models, Animal; Diterpenes; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Male; Mice; Mice, Inbred ICR; Microglia; NADPH Oxidases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrosation; Phosphatidylinositol 3-Kinase; Reactive Oxygen Species; Stroke; Superoxides; Tyrosine; Up-Regulation | 2011 |
Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation.
Topics: Animals; Antioxidants; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Flavanones; Gene Expression Regulation; Hyperalgesia; Mice; Mice, Inbred C57BL; Neural Conduction; Oligonucleotides, Antisense; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reaction Time; Receptors, Eicosanoid; Sciatic Nerve; Spinal Cord; Statistics, Nonparametric; Tyrosine | 2011 |
The antithrombotic activity of EP224283, a neutralizable dual factor Xa inhibitor/glycoprotein IIbIIIa antagonist, exceeds that of the coadministered parent compounds.
Topics: Animals; Biotin; Disease Models, Animal; Drug Combinations; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligosaccharides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rats; Thromboembolism; Tirofiban; Tyrosine | 2011 |
Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues.
Topics: Abnormalities, Multiple; Animals; Claudins; Cytoskeleton; Disease Models, Animal; Ephrin-B2; Ephrin-B3; Esophagus; Female; Larynx; Male; Mice; Morphogenesis; Palate; PDZ Domains; Phosphorylation; Protein Binding; Receptors, Eph Family; Signal Transduction; Trachea; Tyrosine | 2011 |
Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice.
Topics: Adiponectin; Analysis of Variance; Animals; Aorta; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Inflammation Mediators; Interferon-gamma; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Physical Exertion; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2011 |
Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice.
Topics: Animals; Disease Models, Animal; Genetic Carrier Screening; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mutation; Phenylalanine; Phosphorylation; Presbycusis; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ret; Spiral Ganglion; Tyrosine; Up-Regulation | 2012 |
Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Cerium; Disease Models, Animal; Free Radical Scavengers; Hippocampus; Mice; Nanoparticles; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine | 2011 |
Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis.
Topics: Analgesics; Animals; Antioxidants; Bone Resorption; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Iodoacetates; Knee Joint; Male; Matrix Metalloproteinase 13; Osteoarthritis; Pain; Plant Extracts; Proanthocyanidins; Rats; Rats, Wistar; Seeds; Tomography, Emission-Computed; Tyrosine; Vitis | 2011 |
Interplay of endothelial and inducible nitric oxide synthases modulates the vascular response to ischaemia-reperfusion in the rabbit lung.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Lung; NADPH Oxidases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Phosphorylation; Pulmonary Artery; Pulmonary Circulation; Rabbits; Reactive Nitrogen Species; Reperfusion Injury; Respiration, Artificial; Time Factors; Tyrosine; Vascular Resistance; Vasoconstriction | 2012 |
Transactivated EGFR mediates α₁-AR-induced STAT3 activation and cardiac hypertrophy.
Topics: Active Transport, Cell Nucleus; ADAM Proteins; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Male; Mice; Mice, Inbred C57BL; Myocardium; Phenylephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Adrenergic, alpha-1; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Time Factors; Tyrosine | 2011 |
Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction.
Topics: Administration, Oral; Angiogenesis Inducing Agents; Animals; Biopterins; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; GTP Cyclohydrolase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pterins; Recovery of Function; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Ventricular Function, Left | 2011 |
Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Biophysics; Brain; Disease Models, Animal; Drug Combinations; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Nitric Oxide Synthase Type II; Patch-Clamp Techniques; Peptide Fragments; Peroxynitrous Acid; Plaque, Amyloid; Presenilin-1; Tyrosine | 2011 |
SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Aniline Compounds; Animals; Brain; Calcium-Binding Proteins; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Gene Expression Regulation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Phenyl Ethers; Phosphorylation; Rotarod Performance Test; Sodium-Calcium Exchanger; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2011 |
Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism.
Topics: Albinism, Oculocutaneous; Animals; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Enzyme Stability; Eye Color; Female; Humans; Melanins; Melanocytes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Models, Molecular; Monophenol Monooxygenase; Mutation; Nitrobenzoates; Pregnancy; Skin Pigmentation; Tyrosine | 2011 |
Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease.
Topics: Airway Remodeling; Animals; Dinoprost; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Female; Guinea Pigs; Hypertension, Pulmonary; Inflammation; Lung; Oxidative Stress; Peroxidase; Pulmonary Disease, Chronic Obstructive; Purines; Smoking; Thiones; Thioxanthenes; Tyrosine | 2012 |
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Gliosis; Glutathione; Humans; Lipid Peroxidation; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Neurons; Organophosphorus Compounds; Oxidative Stress; Peptide Fragments; Retention, Psychology; Rhodamines; Space Perception; Time Factors; Tyrosine; Ubiquinone | 2011 |
Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.
Topics: Animals; Disease Models, Animal; Hand Strength; Hypertrophy; Mice; Mice, Transgenic; Muscle Contraction; Muscle Weakness; Muscle, Skeletal; Mutation; Myopathies, Nemaline; Phenotype; Tyrosine | 2011 |
Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models.
Topics: Ammonia; Animals; Cerebellum; Cognition; Disease Models, Animal; Hepatic Encephalopathy; Humans; Hyperammonemia; Male; Models, Animal; Nitro Compounds; Phosphorylation; Portacaval Shunt, Surgical; Protein Processing, Post-Translational; Proteomics; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2012 |
Subtotal nephrectomy plus coronary ligation leads to more pronounced damage in both organs than either nephrectomy or coronary ligation.
Topics: Animals; Blood Pressure; Cardio-Renal Syndrome; Coronary Stenosis; Disease Models, Animal; Gene Expression; Heart Failure; Ligation; Male; Myocarditis; Nephrectomy; Nephritis; Nitrates; Nitrites; Peptidyl-Dipeptidase A; Prorenin Receptor; Rats; Rats, Inbred Lew; Receptors, Cell Surface; Renal Insufficiency, Chronic; Renin; Thiobarbituric Acid Reactive Substances; Tyrosine; Ultrasonography | 2012 |
Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus.
Topics: Animals; Antioxidants; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Disease Models, Animal; Humans; Liver; Male; Microcirculation; Oxidative Stress; Phenols; Rats; Rats, Wistar; Tyrosine | 2013 |
Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: attenuation by a lipophilic metalloporphyrin.
Topics: Aconitate Hydratase; Adenine Nucleotides; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Chromatography, High Pressure Liquid; Coenzyme A; Disease Models, Animal; Electroencephalography; Epilepsy; Fumarate Hydratase; Glutathione; Glutathione Disulfide; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Oxidative Stress; Superoxide Dismutase; Tyrosine | 2012 |
Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice.
Topics: Acute Disease; Alcohol Drinking; Alcoholism; Animals; Argininosuccinate Synthase; Chronic Disease; Cytochrome P-450 CYP2E1; Disease Models, Animal; Down-Regulation; Ethanol; Female; Hepatocytes; Immunohistochemistry; Lipid Peroxidation; Liver Diseases, Alcoholic; Male; Mice; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Tyrosine | 2012 |
Tirofiban versus abciximab: tirofiban is administered at suboptimal dosages when evaluated in an arterial thrombosis model in non-human primates.
Topics: Abciximab; Animals; Antibodies, Monoclonal; Anticoagulants; Disease Models, Animal; Immunoglobulin Fab Fragments; Primates; Thrombosis; Tirofiban; Treatment Outcome; Tyrosine | 2012 |
Bone regeneration in a rabbit critical-sized calvarial model using tyrosine-derived polycarbonate scaffolds.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cattle; Disease Models, Animal; Elastic Modulus; Humans; Implants, Experimental; Male; Polycarboxylate Cement; Rabbits; Recombinant Proteins; Skull; Tissue Scaffolds; Transforming Growth Factor beta; Tyrosine; X-Ray Microtomography | 2012 |
Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Hyperglycemia; Hyperinsulinism; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Superoxides; Time Factors; Tyrosine | 2012 |
Involvement of nitrosative stress in experimental periodontitis in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Activation; Male; Nitric Oxide Synthase Type II; Periodontitis; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Streptozocin; Stress, Physiological; Tyrosine | 2012 |
Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blotting, Western; Dexmedetomidine; Disease Models, Animal; Hyperalgesia; Male; Pain, Postoperative; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Remifentanil; Spinal Cord; Tyrosine | 2012 |
Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism.
Topics: Animals; Autistic Disorder; Bacterial Proteins; Biomarkers; Chlorogenic Acid; Clostridium; Disease Models, Animal; Fungal Proteins; Glycine; Hippurates; Humans; Intestines; Phenylalanine; Phenylalanine Ammonia-Lyase; Rats; Stereoisomerism; Systems Biology; Tryptophan; Tyrosine; Yeasts | 2012 |
Tyrosine impairs enzymes of energy metabolism in cerebral cortex of rats.
Topics: Adenylate Kinase; Animals; Cerebral Cortex; Creatine; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Glutathione; Humans; Mitochondria; Nervous System Diseases; Pyruvate Kinase; Rats; Rats, Wistar; Tyrosine; Tyrosine Transaminase; Tyrosinemias | 2012 |
Inhibition of FAK prevents blister formation in the neonatal mouse model of pemphigus vulgaris.
Topics: Acantholysis; Animals; Animals, Newborn; Blister; Caspase Inhibitors; Disease Models, Animal; ErbB Receptors; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunization, Passive; Immunoglobulin G; Mice; Mice, Inbred C57BL; Models, Biological; Pemphigus; Phosphorylation; Protein Kinase Inhibitors; src-Family Kinases; TOR Serine-Threonine Kinases; Tyrosine | 2012 |
Reversal of metabolic and neurological symptoms of phenylketonuric mice treated with a PAH containing helper-dependent adenoviral vector.
Topics: Adenoviridae; Animals; Disease Models, Animal; Electrophysiology; Genetic Therapy; Genetic Vectors; Humans; Learning Disabilities; Mice; N-Methylaspartate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pigmentation; Tyrosine | 2012 |
Catalytic peroxynitrite decomposition improves reperfusion injury after heart transplantation.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Coronary Circulation; Disease Models, Animal; Endothelium, Vascular; Energy Metabolism; Heart Transplantation; Immunohistochemistry; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Inbred Lew; Time Factors; Tyrosine; Vasodilation; Ventricular Function, Left; Ventricular Pressure | 2012 |
Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.
Topics: Animals; Animals, Newborn; Blotting, Western; c-Mer Tyrosine Kinase; Disease Models, Animal; Electroretinography; Follow-Up Studies; Genetic Therapy; Genetic Vectors; Humans; Immunohistochemistry; Injections; Microscopy, Electron, Transmission; Mutation; Plasmids; Proto-Oncogene Proteins; Rats; Rats, Mutant Strains; Receptor Protein-Tyrosine Kinases; Retina; Retinal Pigment Epithelium; Retinitis Pigmentosa; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; Tomography, Optical Coherence; Transgenes; Tyrosine | 2012 |
Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes.
Topics: Animals; Benzoquinones; Calcium; Diabetic Nephropathies; Diet, High-Fat; Disease Models, Animal; HSP90 Heat-Shock Proteins; Kaplan-Meier Estimate; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Lactams, Macrocyclic; Male; Mice; Mice, Knockout; Mitochondria; Renal Insufficiency; Tyrosine | 2012 |
In vivo catecholaminergic metabolism in the medial prefrontal cortex of ENU2 mice: an investigation of the cortical dopamine deficit in phenylketonuria.
Topics: Animals; Catecholamines; Disease Models, Animal; Dopamine; Levodopa; Male; Mice; Mice, Mutant Strains; Phenylalanine Hydroxylase; Phenylketonurias; Prefrontal Cortex; Synaptic Transmission; Tyrosine; Tyrosine 3-Monooxygenase | 2012 |
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium-Binding Proteins; Cerebral Cortex; Deoxyguanosine; Dinoprostone; Disease Models, Animal; Encephalitis; Free Radical Scavengers; Free Radicals; Gene Expression Regulation; Humans; Ibuprofen; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Motor Neurons; Oxidative Stress; Riluzole; Spinal Cord; Sulfasalazine; Superoxide Dismutase; Tyrosine | 2012 |
Impact of treadmill running and sex on hippocampal neurogenesis in the mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Animals; Bromodeoxyuridine; Cell Proliferation; Cell Survival; Dentate Gyrus; Deoxyguanosine; Disease Models, Animal; Exercise Test; Female; Gene Expression Regulation; Hippocampus; Intercellular Signaling Peptides and Proteins; Male; Mice; Neurogenesis; Neurons; Oxidative Stress; Phenotype; Physical Conditioning, Animal; RNA, Messenger; Sex Characteristics; Tyrosine | 2012 |
Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood-Brain Barrier; Calcium-Binding Proteins; Cell Death; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Gaucher Disease; Gene Expression Regulation, Developmental; Glucosylceramidase; Ibuprofen; Immunoglobulin G; Intercellular Adhesion Molecule-1; Intermediate Filament Proteins; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microfilament Proteins; Microglia; Nerve Tissue Proteins; Nestin; Neurons; TATA Box; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2012 |
Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone.
Topics: Actins; Animals; Cell Hypoxia; Cerebrovascular Circulation; Diabetes Mellitus, Type 2; Disease Models, Animal; Hyperemia; Male; Metalloporphyrins; Middle Cerebral Artery; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2012 |
Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydrogen; Lipoproteins, LDL; Lysine; Male; Oxidative Stress; Periodontitis; Rats; Rats, Wistar; Reactive Oxygen Species; Statistics, Nonparametric; Tyrosine; Water | 2012 |
Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model.
Topics: Activating Transcription Factor 3; Animals; Apoptosis; Ascorbic Acid; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Enzymologic; Glutamate-Cysteine Ligase; Glutathione Disulfide; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Lung; Mice; Oxidation-Reduction; Oxidative Stress; Pulmonary Fibrosis; Respiratory Mucosa; Transcription, Genetic; Transforming Growth Factor beta1; Tyrosine | 2012 |
Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Capillary Permeability; Disease Models, Animal; Female; Lung; Microcirculation; Nitric Oxide; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Pulmonary Circulation; Pulmonary Edema; Pulmonary Gas Exchange; RNA, Messenger; Sepsis; Sheep; Smoke Inhalation Injury; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A | 2012 |
Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization.
Topics: Age Factors; Aging; Animals; Blood Flow Velocity; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Hindlimb; Ischemia; Laser-Doppler Flowmetry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; NADPH Oxidase 2; NADPH Oxidases; Neovascularization, Physiologic; Oxidative Stress; Recovery of Function; Regional Blood Flow; Stem Cells; Superoxides; Time Factors; Tyrosine; Vascular Diseases | 2012 |
Neuroglobin-overexpression reduces traumatic brain lesion size in mice.
Topics: Analysis of Variance; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Gait Disorders, Neurologic; Gene Expression Regulation; Globins; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neuroglobin; Neuroprotective Agents; Seizures; Space Perception; Tyrosine | 2012 |
SIRPα interacts with nephrin at the podocyte slit diaphragm.
Topics: Animals; Antigens, Differentiation; Disease Models, Animal; Humans; Kidney Glomerulus; Membrane Proteins; Mutation; Nephrotic Syndrome; Phosphorylation; Podocytes; Protein Binding; Proteinuria; Rats; Receptors, Immunologic; Tyrosine | 2012 |
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclooxygenase 2; Disease Models, Animal; Galactosamine; Gene Expression Regulation; Heme Oxygenase-1; Hepatitis; Interleukin-6; Lactones; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 8; NF-kappa B; Phosphorylation; Sesquiterpenes; STAT3 Transcription Factor; Transaminases; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2013 |
Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Folic Acid; Hyperalgesia; Male; Nerve Fibers; Neural Conduction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyridoxal Phosphate; Rats; Rats, Zucker; Sciatic Nerve; Tibial Nerve; Tyrosine; Vitamin B 12 | 2012 |
Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Animals, Newborn; Blood Gas Analysis; Catalase; Cerebral Cortex; Disease Models, Animal; Female; Glutathione; Hemodynamics; Hydrogen Peroxide; Hypoxia; Infusions, Intravenous; Lactic Acid; Male; Oxidation-Reduction; Oxidative Stress; Oxygen; Pulmonary Alveoli; Resuscitation; Sodium Bicarbonate; Superoxide Dismutase; Swine; Tyrosine | 2012 |
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.
Topics: alpha-Synuclein; Animals; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Focal Adhesion Protein-Tyrosine Kinases; HSC70 Heat-Shock Proteins; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Tyrosine | 2012 |
N-methyl-D-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Hemodynamics; Interleukin-6; Kynurenic Acid; Male; Microcirculation; Nitric Oxide; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Xanthine Dehydrogenase | 2012 |
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Topics: Animals; Cadherins; CD47 Antigen; Chemotaxis, Leukocyte; Disease Models, Animal; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Recombinant Proteins; Signal Transduction; T-Lymphocyte Subsets; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy.
Topics: Aldehyde Reductase; Animals; Animals, Newborn; Blotting, Western; Calcium-Binding Proteins; Capillary Permeability; Cell Movement; Cell Proliferation; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; I-kappa B Proteins; Immunohistochemistry; Infant, Newborn; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Nerve Tissue Proteins; Oxidative Stress; Oxygen; Poly Adenosine Diphosphate Ribose; Proto-Oncogene Proteins c-akt; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Tyrosine; Vascular Endothelial Growth Factor A | 2012 |
Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.
Topics: Analysis of Variance; Animals; Carrageenan; CD11b Antigen; Cell Line, Transformed; Chromatography, Liquid; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electrochemical Techniques; Enkephalin, Methionine; Glial Fibrillary Acidic Protein; Humans; Hyperalgesia; Injections, Spinal; Male; Medulla Oblongata; Metalloporphyrins; Microinjections; Neuroglia; Neurons; Opioid Peptides; Pain; Pain Measurement; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2012 |
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
Topics: Animals; Astrocytes; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Glioblastoma; Humans; Mice; Mice, Mutant Strains; Mice, Nude; Phosphorylation; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrosine | 2012 |
EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection.
Topics: Adenosine Triphosphatases; Animals; Cadherins; Candida albicans; Candidiasis, Oral; Disease Models, Animal; Endocytosis; Epithelial Cells; ErbB Receptors; Fungal Proteins; Male; Mice; Mice, Inbred BALB C; Mouth Mucosa; NIH 3T3 Cells; Phosphorylation; Receptor, ErbB-2; Signal Transduction; Tyrosine | 2012 |
[Characterization of the antiinflammatory properties of methane inhalation during ischaemia-reperfusion].
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Dioxide; Disease Models, Animal; Dogs; Hemodynamics; Inflammation; Intestine, Small; Leukocytes; Methane; Peroxidase; Random Allocation; Reperfusion Injury; Superoxides; Tyrosine | 2012 |
Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Avoidance Learning; Benzene Derivatives; Brain; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Male; Maze Learning; Neuroprotective Agents; Organoselenium Compounds; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Tyrosine | 2013 |
Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Disease Models, Animal; Functional Laterality; Gene Expression Regulation; Mice; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Protein Isoforms; RNA, Messenger; Time Factors; Tyrosine | 2012 |
Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.
Topics: Angiopoietin-2; Animals; Arginine Vasopressin; Arterial Pressure; Blood Vessels; Capillary Permeability; Disease Models, Animal; Female; Hemodynamics; Infusions, Intravenous; Methicillin-Resistant Staphylococcus aureus; Neutrophil Infiltration; Nitric Oxide; Pneumonia, Staphylococcal; Receptors, Vasopressin; Sepsis; Sheep; Smoke Inhalation Injury; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vasoconstriction; Vasoconstrictor Agents; Vasotocin; Ventricular Function, Left | 2012 |
Characterization of antinociceptive potency of endomorphin-2 derivatives with unnatural amino acids in rats.
Topics: Aminobutyrates; Analgesics, Opioid; Animals; Arthralgia; Carboxylic Acids; Chronic Pain; Cyclobutanes; Disease Models, Animal; Drug Design; Edema; Hyperalgesia; Injections, Spinal; Male; Nociceptors; Oligopeptides; p-Fluorophenylalanine; Rats; Rats, Wistar; Tyrosine | 2012 |
Preconditioning protects the heart in a prolonged uremic condition.
Topics: Angiotensin II; Animals; Biomarkers; Creatinine; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Urea; Uremia; Uric Acid; Ventricular Function, Left | 2012 |
Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.
Topics: Amino Acid Sequence; Animals; Cell Proliferation; Central Nervous System Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; HEK293 Cells; Humans; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Tyrosine | 2012 |
Previous exposure to cigarette smoke aggravates experimental cyclosporine-induced nephrotoxicity.
Topics: Actins; Animals; Cyclosporine; Disease Models, Animal; Drug Synergism; Fibrosis; Glomerular Filtration Rate; Hematocrit; Hemodynamics; Humans; Immunosuppressive Agents; Kidney; Male; Nephritis, Interstitial; Rats; Rats, Wistar; Smoking; Tyrosine; Vimentin | 2012 |
L-tyrosine administration increases acetylcholinesterase activity in rats.
Topics: Acetylcholinesterase; Animals; Animals, Newborn; Animals, Suckling; Brain Chemistry; Disease Models, Animal; Drug Administration Schedule; Enzyme Induction; GPI-Linked Proteins; Injections, Intraperitoneal; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine; Tyrosinemias | 2012 |
The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Carrier Proteins; Disease Models, Animal; E-Selectin; Endothelial Cells; Evans Blue; Functional Laterality; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 9; Neoplasm Proteins; Neurons; Neuroprotective Agents; NF-kappaB-Inducing Kinase; Nitric Oxide; Nitrites; Nucleocytoplasmic Transport Proteins; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Sprague-Dawley; S-Nitrosoglutathione; Statistics, Nonparametric; Time Factors; Tyrosine; Zonula Occludens-1 Protein | 2012 |
Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes.
Topics: Aconitate Hydratase; Animals; Citric Acid Cycle; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Down-Regulation; Ganglia, Spinal; Glycolysis; Lipid Peroxidation; Male; Mice; Mice, Mutant Strains; Neurons; Oxidative Stress; Peripheral Nervous System; Receptors, Leptin; Sciatic Nerve; Sural Nerve; Tyrosine | 2013 |
Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Encephalitis; Fluoresceins; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; NADPH Oxidases; Neuroglia; Neuroprotective Agents; Neurotransmitter Agents; Nitric Oxide Synthase Type II; Organic Chemicals; Tyrosine; Tyrosine 3-Monooxygenase | 2012 |
Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Kidney Cortex; Male; Mitochondrial Proteins; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tyrosine | 2013 |
Decreased pulmonary c-Cbl expression and tyrosine phosphorylation in the nitrofen-induced rat model of congenital diaphragmatic hernia.
Topics: Animals; Disease Models, Animal; Female; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Lung; Phenyl Ethers; Phosphorylation; Proto-Oncogene Proteins c-cbl; Rats; Rats, Sprague-Dawley; Tyrosine | 2013 |
Local gene delivery of heme oxygenase-1 by adeno-associated virus into osteoarthritic mouse joints exhibiting synovial oxidative stress.
Topics: Animals; Bone Remodeling; Dependovirus; Disease Models, Animal; Gene Transfer Techniques; Heme Oxygenase-1; Hydrogen Peroxide; In Vitro Techniques; Injections, Intra-Articular; Joints; Male; Membrane Proteins; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Mice, Mutant Strains; Osteoarthritis; Oxidative Stress; Synovial Membrane; Transduction, Genetic; Tyrosine | 2013 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Collagen Type I; Dioxoles; Disease Models, Animal; Down-Regulation; Fibrosis; Heart; Hypertension; Hypertrophy, Left Ventricular; Lignans; Male; Malondialdehyde; Myocytes, Cardiac; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Transforming Growth Factor beta1; Tyrosine; Ventricular Remodeling | 2013 |
Notch-dependent regulation of the ischemic vasodilatory response--brief report.
Topics: Animals; Cell Adhesion Molecules; Collateral Circulation; Disease Models, Animal; Endothelium, Vascular; Femoral Artery; Hindlimb; Ischemia; Laser-Doppler Flowmetry; Ligation; Mice; Mice, Transgenic; Microfilament Proteins; Muscle, Skeletal; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphoproteins; Phosphorylation; Receptors, Notch; Regional Blood Flow; Signal Transduction; Transcription Factors; Tyrosine; Vasodilation | 2013 |
Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B.
Topics: Alanine Transaminase; Animals; Biomarkers; Blotting, Western; Chronic Disease; Dinoprost; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Endothelin-1; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Male; NF-kappa B; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factor AP-1; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade.
Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Biphenyl Compounds; Breath Tests; Disease Models, Animal; Female; Fibrosis; Hypochlorous Acid; Injections, Intradermal; Irbesartan; Lung; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidants; Pulmonary Fibrosis; Scleroderma, Systemic; Skin; Tetrazoles; Tyrosine | 2013 |
Catalpol decreases peroxynitrite formation and consequently exerts cardioprotective effects against ischemia/reperfusion insult.
Topics: Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Down-Regulation; Enzyme Activation; Free Radical Scavengers; Injections, Intraperitoneal; Iridoid Glucosides; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2013 |
Evaluation of inflammatory response to acute ischemia using near-infrared fluorescent reactive oxygen sensors.
Topics: Animals; Biosensing Techniques; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Fluorescence; Fluorescent Dyes; Hindlimb; Immunohistochemistry; Inflammation; Ischemia; Mice; Mice, Inbred C57BL; Muscles; Reactive Oxygen Species; Spectroscopy, Near-Infrared; Tissue Distribution; Tyrosine | 2013 |
Lack of cell stress markers in fibrous cap cells in the left main coronary artery.
Topics: Animals; Biomarkers; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endothelial Cells; Fibrosis; Heat-Shock Proteins; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Plaque, Atherosclerotic; Rabbits; Stress, Physiological; Transcription Factor CHOP; Tyrosine | 2013 |
Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model.
Topics: Analgesics; Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Breast Neoplasms; Cell Division; Disease Models, Animal; Disease Progression; ErbB Receptors; Female; Isoflavones; Mice; Mice, Inbred ICR; Mice, Nude; Mitotic Index; Neoplasm Metastasis; Osteoclasts; Phosphorylation; Treatment Outcome; Tyrosine | 2002 |
Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia.
Topics: Afferent Pathways; Anesthetics, Local; Animals; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Freund's Adjuvant; GTP-Binding Proteins; Hindlimb; Hyperalgesia; Inflammation; Male; Pain Measurement; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; src-Family Kinases; Tyrosine | 2002 |
Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome.
Topics: Adolescent; Adult; Amidines; Animals; Benzylamines; Blood Proteins; Case-Control Studies; Disease Models, Animal; Disease Vectors; Enzyme Inhibitors; Female; Hantavirus Pulmonary Syndrome; Humans; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred NZB; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Orthohantavirus; Peromyscus; Reactive Nitrogen Species; Reactive Oxygen Species; Sin Nombre virus; Tyrosine | 2002 |
Mitochondrial integrity and function in atherogenesis.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Disease Models, Animal; Disease Progression; DNA Damage; DNA, Mitochondrial; Heterozygote; Homozygote; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Phenotype; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2002 |
Potential of sanguiin H-6 against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite in vivo.
Topics: Animals; Blood Urea Nitrogen; Caspase 3; Caspases; Creatinine; Disease Models, Animal; DNA Fragmentation; Hydrolyzable Tannins; Ischemia; Kidney; Kidney Diseases; Lipopolysaccharides; Male; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Sanguisorba; Tannins; Tyrosine | 2002 |
Distinct renal injury in early atherosclerosis and renovascular disease.
Topics: Animals; Antioxidants; Arteriosclerosis; Cholesterol, Dietary; Disease Models, Animal; Disease Progression; Glomerular Filtration Rate; Hemodynamics; Hypercholesterolemia; Hypertension; Immunohistochemistry; Kidney; Kidney Function Tests; Kidney Tubules; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Regional Blood Flow; Renal Artery Obstruction; Swine; Tomography, X-Ray Computed; Tyrosine; Vasodilator Agents | 2002 |
Human thrombocytes are able to induce a myocardial dysfunction in the ischemic and reperfused guinea pig heart mediated by free radicals-role of the GPIIb/IIIa-blocker tirofiban.
Topics: Animals; Blood Platelets; Cardiac Output; Disease Models, Animal; Fibrinolytic Agents; Guinea Pigs; Humans; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Superoxide Dismutase; Tirofiban; Tyrosine | 2002 |
Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apoptosis; Biotin; Brain; Brain Edema; Caspase 3; Caspases; Disease Models, Animal; Energy Metabolism; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Nitric Oxide Synthase; Reperfusion Injury; Survival Rate; Swine; Treatment Outcome; Tyrosine | 2002 |
Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.
Topics: Animals; Aorta; Brain; Disease Models, Animal; Enzyme Activation; Extracellular Space; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Middle Cerebral Artery; Oxidative Stress; RNA, Messenger; Subarachnoid Hemorrhage; Superoxide Dismutase; Tyrosine; Vascular Patency; Vasospasm, Intracranial | 2002 |
Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats.
Topics: Animals; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Disease Models, Animal; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Tyrosine | 2002 |
Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7- and 21-day-old rats.
Topics: Age Factors; Animals; Carotid Arteries; Disease Models, Animal; Hypoxia; Hypoxia-Ischemia, Brain; Immunoblotting; Ligation; Nerve Tissue Proteins; Phosphorylation; Prosencephalon; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2002 |
The nitroxide antioxidant tempol is cerebroprotective against focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Infarction, Middle Cerebral Artery; Male; Maze Learning; Motor Activity; Neuroprotective Agents; Rats; Rats, Inbred SHR; Spin Labels; Treatment Outcome; Tyrosine | 2002 |
Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases.
Topics: Animals; Blood Vessels; Coronary Vessels; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Tyrosine | 2002 |
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits.
Topics: Animals; Antioxidants; beta Carotene; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Free Radicals; Hyperlipidemias; Immunohistochemistry; Male; Nitric Oxide; Nitroglycerin; Oxidative Stress; Rabbits; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine; Vasodilator Agents | 2002 |
Hypothalamic-pituitary-adrenal responses to weight loss in mice following diet restriction, activity or separation stress: effects of tyrosine.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety, Separation; Body Weight; Brain; Catecholamines; Diet, Reducing; Disease Models, Animal; Female; Glucocorticoids; Hypothalamo-Hypophyseal System; Mice; Mice, Inbred Strains; Motor Activity; Norepinephrine; Pituitary-Adrenal System; Starvation; Stress, Psychological; Tyrosine; Weight Loss | 2002 |
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.
Topics: Adrenergic alpha-Antagonists; alpha-Synuclein; Animals; Body Weight; Brain; Cerebellum; Disease Models, Animal; Female; Inclusion Bodies; Macromolecular Substances; Male; Mice; Mice, Transgenic; Motor Activity; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nitrates; Oligodendroglia; Phosphorylation; Prazosin; Receptors, Adrenergic, alpha-1; Spinal Cord; Survival Rate; Synucleins; Tyrosine; Ubiquitin | 2002 |
Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Oxidopamine; Parkinson Disease; PC12 Cells; Phosphorylation; Protein Tyrosine Phosphatases; Quinpirole; Rats; Receptors, Dopamine D2; Sympatholytics; Tyrosine; Vanadates | 2002 |
Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade.
Topics: Animals; Blood Glucose; Disease Models, Animal; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle Denervation; Muscle, Skeletal; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2003 |
HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Movement; Disease Models, Animal; Hepatocyte Growth Factor; Interleukin-1; Keratins; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Phosphorylation; Pigment Epithelium of Eye; Precipitin Tests; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-met; Rabbits; Retinal Perforations; Tyrosine; Vitreoretinopathy, Proliferative; Vitreous Body | 2002 |
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Ascorbic Acid; Biopterins; Cyclic AMP; Cyclic GMP; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; In Vitro Techniques; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Superoxides; Time; Tyrosine; Vasomotor System; Vitamin E | 2003 |
Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice.
Topics: Animals; Aorta; Apolipoproteins E; Arginine; Arteriosclerosis; Biopterins; Blotting, Western; Cholesterol; Disease Models, Animal; Immunohistochemistry; Isoenzymes; Malondialdehyde; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Staining and Labeling; Thiobarbituric Acid Reactive Substances; Tyrosine | 2003 |
Effect of NOS2 gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Experimental; Autoantibodies; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Models, Animal; Female; In Situ Nick-End Labeling; Interleukin-1; Lipopolysaccharides; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Tyrosine | 2003 |
Mechanism of vasculitis and aneurysms in Kawasaki disease: role of nitric oxide.
Topics: Aneurysm; Animals; Blotting, Western; Cell Wall; Coronary Vessels; Disease Models, Animal; Hemorrhage; Immunohistochemistry; Inflammation; Lacticaseibacillus casei; Macrophages; Male; Mice; Mucocutaneous Lymph Node Syndrome; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Thrombosis; Time Factors; Tyrosine; Vasculitis | 2003 |
Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions.
Topics: Alternative Splicing; Animals; Cytoskeletal Proteins; Disease Models, Animal; Dystrophin-Associated Proteins; Female; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Electron; Muscle, Skeletal; Muscular Dystrophy, Animal; Neuromuscular Junction; Phosphorylation; Protein Isoforms; Receptors, Cholinergic; Recombinant Fusion Proteins; Sarcolemma; Synaptic Membranes; Tendons; Tyrosine | 2003 |
D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity.
Topics: Animals; Arthritis, Experimental; Crystallography, X-Ray; Disease Models, Animal; Enzyme Inhibitors; Humans; Inflammation; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Structure-Activity Relationship; Tyrosine | 2003 |
Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Cholesterol, Dietary; Disease Models, Animal; Female; Hypercholesterolemia; Immunohistochemistry; Kidney; Kidney Function Tests; Nitric Oxide Synthase; Probability; Random Allocation; Receptors, LDL; Receptors, Oxidized LDL; Reference Values; Renal Circulation; Sensitivity and Specificity; Simvastatin; Swine; Tyrosine | 2003 |
Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation.
Topics: Animals; Chronic Disease; Collagen; Disease Models, Animal; DNA; Enzyme Inhibitors; Fibroblasts; Heart Failure; Hemodynamics; Ligation; Male; Mesylates; Myocardial Infarction; Myocardium; Neprilysin; Organ Size; Peptide Hydrolases; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Tyrosine; Ventricular Remodeling | 2003 |
Effects of GP IIb/IIIa receptor inhibitor tirofiban (aggrastat) in ex vivo canine arteriovenous shunt model of stent thrombosis.
Topics: Animals; Arteriovenous Shunt, Surgical; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fibrinolytic Agents; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Tirofiban; Tyrosine | 2003 |
Increased endothelin-induced Ca2+ signaling, tyrosine phosphorylation, and coronary artery disease in diabetic dyslipidemic Swine are prevented by atorvastatin.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Calcium; Calcium Signaling; Coronary Artery Disease; Diabetes Complications; Diet; Disease Models, Animal; Endothelin-1; Endothelins; Heptanoic Acids; Hyperlipidemias; Male; Phosphorylation; Pyrroles; Receptor, Endothelin A; Receptors, Endothelin; Swine; Tyrosine | 2003 |
Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cell Differentiation; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Female; Free Radicals; Humans; Hypoxia, Brain; Immunohistochemistry; Infant, Newborn; Neuronal Plasticity; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Rats; Rats, Wistar; Tyrosine; Up-Regulation | 2003 |
Generation of activated sialoadhesin-positive microglia during retinal degeneration.
Topics: Animals; Apoptosis; CD11 Antigens; Cell Adhesion Molecules; Cell Division; Cell Movement; Disease Models, Animal; Immunoenzyme Techniques; In Situ Nick-End Labeling; Membrane Glycoproteins; Mice; Mice, Inbred CBA; Mice, Mutant Strains; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Photoreceptor Cells; Proliferating Cell Nuclear Antigen; Receptors, Immunologic; Retinal Degeneration; Sialic Acid Binding Ig-like Lectin 1; Sialic Acids; Tyrosine | 2003 |
P-selectin blocking potency of multimeric tyrosine sulfates in vitro and in vivo.
Topics: Acrylic Resins; Animals; Chemotaxis, Leukocyte; Dimerization; Disease Models, Animal; Female; Humans; Inhibitory Concentration 50; Lewis X Antigen; Neutrophils; P-Selectin; Peritonitis; Protein Binding; Rats; Rats, Wistar; Structure-Activity Relationship; Tyrosine | 2003 |
Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice.
Topics: Adipocytes; Animals; Cell Line; Cell Membrane; Cells, Cultured; Chromatography, Thin Layer; Detergents; Disease Models, Animal; DNA, Complementary; Dose-Response Relationship, Drug; Gangliosides; Glucose; Glucose Tolerance Test; Glycogen Synthase; Humans; Insulin; Islets of Langerhans; Mice; Mice, Transgenic; Muscles; Neuraminidase; Octoxynol; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Rats; Receptor, Insulin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transfection; Transgenes; Tyrosine | 2003 |
Differential nitric oxide synthase expression during hepatic ischemia-reperfusion.
Topics: Animals; Blotting, Western; Disease Models, Animal; Fluorescent Antibody Technique; Ischemia; Liver; Liver Diseases; Liver Function Tests; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2003 |
A novel model for rapid induction of apoptosis in spiral ganglions of mice.
Topics: Animals; Apoptosis; Cell Death; Cisplatin; Disease Models, Animal; In Situ Nick-End Labeling; Intermediate Filament Proteins; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Peripherins; Peroxynitrous Acid; Spiral Ganglion; Tyrosine | 2003 |
Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.
Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Mitogens; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-met; Survival Rate; Tumor Cells, Cultured; Tyrosine | 2003 |
Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Behavior, Animal; Benzylamines; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Interactions; Haloperidol; Hippocampus; Homovanillic Acid; Hypothalamus; Locus Coeruleus; Male; Medial Forebrain Bundle; Nerve Degeneration; Neurotoxins; Norepinephrine; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin; Substantia Nigra; Thalamus; Tyrosine | 2003 |
PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma.
Topics: Animals; Brain Injuries; Disease Models, Animal; Enzyme Inhibitors; Male; Microscopy, Confocal; Motor Cortex; Neurons; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Stem Cell Transplantation; Stem Cells; Tyrosine | 2003 |
Relationship between myelin production and dopamine synthesis in the PKU mouse brain.
Topics: Animals; Blotting, Western; Brain; Brain Chemistry; Corpus Striatum; Disease Models, Animal; Dopamine; Food, Formulated; Frontal Lobe; Male; Mice; Mice, Mutant Strains; Myelin Basic Protein; Myelin Sheath; Neurofilament Proteins; Phenylalanine; Phenylketonurias; Phosphorylation; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Critical role of reactive nitrogen species in lung ischemia-reperfusion injury.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Chemokines; Disease Models, Animal; Immunohistochemistry; Inflammation Mediators; Macrophages, Alveolar; Male; Models, Cardiovascular; NF-kappa B; Peroxidase; Peroxynitrous Acid; Rats; Rats, Long-Evans; Reactive Nitrogen Species; Reperfusion Injury; Respiratory Distress Syndrome; Severity of Illness Index; Statistics as Topic; Transcription Factor AP-1; Transcriptional Activation; Tyrosine | 2003 |
Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice.
Topics: Animals; Antioxidants; Blotting, Western; Chemotaxis, Leukocyte; Disease Models, Animal; Drug Evaluation, Preclinical; Immunohistochemistry; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Multiple Organ Failure; Neutrophils; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Poly(ADP-ribose) Polymerases; Pyrrolidines; Random Allocation; Thiocarbamates; Time Factors; Tyrosine; Zymosan | 2003 |
Regulation of insulin receptor substrate-2 tyrosine phosphorylation in animal models of insulin resistance.
Topics: Animals; Dexamethasone; Disease Models, Animal; Down-Regulation; Epinephrine; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Tyrosine | 2003 |
Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide.
Topics: 6-Aminonicotinamide; Angiogenesis Inducing Agents; Animals; Apoptosis; Astrocytes; Brain Stem; Cell Count; Central Nervous System; Cytokines; Disease Models, Animal; Gene Targeting; Glial Fibrillary Acidic Protein; Growth Substances; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Lymphocytes; Macrophages; Malondialdehyde; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Nerve Degeneration; Oxidative Stress; Staining and Labeling; Stem Cells; Teratogens; Tyrosine | 2003 |
Inducible nitric oxide synthase and nitrotyrosine in mice with radiation-induced lung damage.
Topics: Animals; Disease Models, Animal; Female; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Radiation Injuries, Experimental; Radiation Pneumonitis; Tyrosine | 2003 |
Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Focal Adhesion Kinase 2; Ischemic Attack, Transient; Male; Phosphorylation; Prosencephalon; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Tyrosine | 2003 |
Hepatocyte growth factor facilitates colonic mucosal repair in experimental ulcerative colitis in rats.
Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Hepatocyte Growth Factor; Humans; Inflammation; Infusions, Parenteral; Intestinal Mucosa; Kidney; Liver; Organ Size; Phosphorylation; Proto-Oncogene Proteins c-met; Rats; Rats, Wistar; Recombinant Proteins; Spleen; Tyrosine; Weight Loss; Wound Healing | 2003 |
Overlesioned hemiparkinsonian non human primate model: correlation between clinical, neurochemical and histochemical changes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Chemistry; Carotid Arteries; Corpus Striatum; Disease Models, Animal; Dopamine; Female; Fluorine Radioisotopes; Histocytochemistry; Humans; Injections, Intra-Arterial; Macaca mulatta; Male; Neurochemistry; Parkinson Disease, Secondary; Parkinsonian Disorders; Tomography, Emission-Computed; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Hypoxia-induced acute lung injury in murine models of sickle cell disease.
Topics: Acute Disease; Anemia, Sickle Cell; Animals; Disease Models, Animal; Hemoglobin, Sickle; HSP90 Heat-Shock Proteins; Humans; Hypoxia; Lung Diseases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tyrosine | 2004 |
Tyrosinated alpha-tubulin changes following epileptogenic and non-epileptogenic lesions in rat brain cortex.
Topics: Action Potentials; Animals; Cerebral Cortex; Cobalt; Corpus Callosum; Denervation; Disease Models, Animal; Electroencephalography; Epilepsy; Functional Laterality; Male; Neuronal Plasticity; Neurons; Prostheses and Implants; Rats; Rats, Wistar; Tubulin; Tyrosine; Up-Regulation | 2003 |
Nitric oxide system and protein nitration are modified by an acute hypobaric hypoxia in the adult rat hippocampus.
Topics: Animals; Blotting, Western; Cell Count; Disease Models, Animal; Endothelium, Vascular; Glial Fibrillary Acidic Protein; Hippocampus; Hypoxia; Immunohistochemistry; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine | 2003 |
The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia.
Topics: Animals; Blotting, Western; Brain Ischemia; Calmodulin; Carotid Artery, Internal, Dissection; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme Inhibitors; Gerbillinae; Hippocampus; Immunohistochemistry; Indazoles; Ischemic Attack, Transient; Male; Microdialysis; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Reperfusion; Time Factors; Tyrosine | 2003 |
Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance.
Topics: Adipocytes; Adipose Tissue; Animals; Disease Models, Animal; Fasting; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rats; Rats, Wistar; Signal Transduction; Sodium Glutamate; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface.
Topics: Aldosterone; Animals; Calcium; Cell Separation; Coronary Vessels; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Gene Expression Regulation; Genes, MHC Class II; Hydrogen Peroxide; Hyperaldosteronism; Leukocytes, Mononuclear; Lymphocyte Activation; Magnesium; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Nephrectomy; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone; Tyrosine | 2003 |
Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.
Topics: Animals; Antioxidants; Blood Vessels; Carotid Arteries; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Hypercholesterolemia; In Vitro Techniques; Lipids; Male; Nitrates; Nitric Oxide; Nitrites; Rabbits; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors; Tyrosine; Vasodilation | 2003 |
Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.
Topics: Animals; Astrocytes; Behavior, Animal; Benzamides; Benzopyrans; Cell Death; Cells, Cultured; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Hypoglycemia; Isoquinolines; Male; Maze Learning; Mice; Mice, Knockout; Neurons; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Treatment Outcome; Tyrosine | 2003 |
Distribution of nitric oxide synthases and nitrotyrosine in the kidney of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Disease Models, Animal; Endothelium, Vascular; Hypertension; Immunohistochemistry; Kidney; Male; Models, Cardiovascular; Neurons; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tissue Distribution; Tyrosine | 2003 |
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycosaminoglycans; Guanidines; Injections, Intra-Articular; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Synovial Fluid; Synovial Membrane; Synovitis; Tyrosine; Uric Acid; Zymosan | 2004 |
Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation.
Topics: Actinin; Animals; Brain; Cell Membrane; Disease Models, Animal; Disks Large Homolog 4 Protein; Guanylate Kinases; Huntingtin Protein; Huntington Disease; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Phosphorylation; Protein Structure, Tertiary; Protein Subunits; Protein Transport; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tyrosine | 2003 |
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Guinea Pigs; Male; Mice; Molecular Mimicry; Morphine; Pain; Pyrazines; Receptors, Opioid, mu; Tyrosine | 2004 |
Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation.
Topics: Animals; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-1beta; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peptide Fragments; Peroxidase; Pleuropneumonia; Pneumonia; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Sulfides; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Alterations in lens protein tyrosine phosphorylation and phosphatidylinositol 3-kinase signaling during selenite cataract formation.
Topics: Animals; Blotting, Western; Cataract; Cells, Cultured; Crystallins; Disease Models, Animal; Epithelial Cells; Insulin; Insulin-Like Growth Factor I; Lens, Crystalline; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Rabbits; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Selenite; Tyrosine | 2004 |
The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis.
Topics: Animals; Ankle Joint; Antigens, CD; Arthritis, Rheumatoid; Cytokine Receptor gp130; Disease Models, Animal; Flow Cytometry; Genes, pX; Human T-lymphotropic virus 1; Interleukin-6; Lymph Nodes; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Myeloid Cells; Point Mutation; Radiography; Spleen; T-Lymphocyte Subsets; Tyrosine | 2004 |
Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Disease Models, Animal; Image Processing, Computer-Assisted; Immunohistochemistry; Lipid Peroxidation; Male; Mice; Nerve Degeneration; Peroxynitrous Acid; Proteins; Time Factors; Tyrosine | 2004 |
The tyrosine phosphatase inhibitor bis(maltolato)oxovanadium attenuates myocardial reperfusion injury by opening ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Male; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Protein Tyrosine Phosphatases; Pyrones; Rats; Rats, Wistar; Time Factors; Tyrosine; Vanadates | 2004 |
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Isoindoles; Japan; Kidney; Lipopolysaccharides; Lysine; Male; Nitric Oxide; Organoselenium Compounds; Peroxidase; Phytotherapy; Plant Extracts; Plant Roots; Proteinuria; Rats; Rats, Wistar; Reperfusion Injury; Rheum; Superoxide Dismutase; Tyrosine; Uric Acid; Zinc | 2004 |
Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; CD11 Antigens; Cell Movement; Disease Models, Animal; Disease Progression; Female; Integrin alpha Chains; Lipid Peroxidation; Macrophages; Neutrophil Infiltration; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proteins; Rats; Rats, Wistar; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances; Tyrosine | 2004 |
Effect of aminoguanidine in ligature-induced periodontitis in rats.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Enzyme Inhibitors; Gingiva; Guanidines; Ligation; Lipid Peroxidation; Male; Mouth Mucosa; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase; Periodontitis; Poly(ADP-ribose) Polymerases; Random Allocation; Rats; Rats, Sprague-Dawley; Tyrosine | 2004 |
G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact.
Topics: Amino Acid Sequence; Animals; Binding Sites; Disease Models, Animal; DNA-Binding Proteins; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Mutant Strains; Milk Proteins; Neutropenia; Receptors, Granulocyte Colony-Stimulating Factor; Repressor Proteins; Sequence Deletion; Signal Transduction; src Homology Domains; STAT3 Transcription Factor; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors; Tyrosine | 2004 |
Neuroprotective action of halogenated derivatives of L-phenylalanine.
Topics: Animals; Disease Models, Animal; In Vitro Techniques; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Stroke; Synaptic Transmission; Tyrosine | 2004 |
Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease.
Topics: Animals; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Guanidines; Huntington Disease; Lactic Acid; Male; Neostriatum; Neuroglia; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Pyruvic Acid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Tyrosine | 2004 |
Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Benzylamines; Brain Chemistry; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Locus Coeruleus; Male; Motor Activity; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Serotonin; Statistics, Nonparametric; Tyrosine | 2004 |
Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease.
Topics: Animals; Biopterins; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenylalanine; Tyrosine | 2004 |
Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.
Topics: Acute Disease; Analysis of Variance; Animals; Blotting, Western; Calpain; Ceruletide; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Mice; NF-kappa B; Nitric Oxide Synthase; Pancreatitis; Poly(ADP-ribose) Polymerases; Random Allocation; Respiratory Distress Syndrome; Tyrosine | 2004 |
Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Celiac Artery; Disease Models, Animal; Intercellular Adhesion Molecule-1; Intestine, Small; Ischemia; Isoquinolines; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Artery, Superior; Mesenteric Vascular Occlusion; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; Solubility; Tyrosine; Water | 2004 |
Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats.
Topics: Animals; Biomarkers; Catalysis; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors; Fluorescent Dyes; Guanidines; I-kappa B Proteins; Leukocytes; Metalloporphyrins; Models, Cardiovascular; Myocarditis; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine; Xanthenes | 2004 |
Upregulation of endothelial nitric oxide synthase maintains nitric oxide production in the cerebellum of thioacetamide cirrhotic rats.
Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Liver Cirrhosis, Experimental; Male; NADPH Dehydrogenase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Thioacetamide; Tyrosine; Up-Regulation | 2004 |
Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Biomarkers; Biotin; Caspase 3; Caspases; Cell Count; Disease Models, Animal; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Female; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Protein Transport; Rats; Rats, Wistar; Tyrosine | 2004 |
Methylguanidine reduces the development of non septic shock induced by zymosan in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Intestinal Mucosa; Intestines; Kidney; Lipid Peroxidation; Lung; Male; Methylguanidine; Mice; Neutrophils; Pancreas; Peritonitis; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Shock; Tyrosine; Zymosan | 2004 |
Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Biomarkers; Brain; Cells, Cultured; Disease Models, Animal; Down-Regulation; Glutamate-Ammonia Ligase; Lipid Peroxidation; Memory Disorders; Mice; Mice, Inbred Strains; Neurons; Oligonucleotides, Antisense; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Tyrosine | 2004 |
MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia.
Topics: Animals; Body Water; Brain; Brain Ischemia; Cerebrovascular Circulation; Diffusion; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; DNA-Binding Proteins; fas Receptor; Functional Laterality; Infarction, Middle Cerebral Artery; Phosphorylation; Rats; Rats, Sprague-Dawley; Reaction Time; Reperfusion Injury; STAT1 Transcription Factor; Trans-Activators; Tyrosine; Up-Regulation | 2004 |
Oxidative stress-induced DNA damage in the synovial cells of the temporomandibular joint in the rat.
Topics: Animals; Disease Models, Animal; DNA Damage; Hyperplasia; Joint Instability; Male; Mandibular Condyle; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Stress, Mechanical; Synovial Membrane; Synovitis; Temporomandibular Joint; Temporomandibular Joint Disorders; Tyrosine | 2004 |
Renal proximal tubular cells acquire resistance to cell death stimuli in mice with hereditary tyrosinemia type 1.
Topics: Animals; Caspase 3; Caspase 9; Caspases; Cyclohexanones; Disease Models, Animal; DNA Fragmentation; Enzyme Inhibitors; Hepatocytes; Homogentisic Acid; Hydrolases; In Situ Nick-End Labeling; Kidney Tubules, Proximal; Mice; Mice, Knockout; Nitrobenzoates; Survival Rate; Tyrosine; Tyrosinemias | 2004 |
Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery.
Topics: Angioplasty, Balloon; Animals; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Male; Nitric Oxide Synthase; Rabbits; Regeneration; Subclavian Artery; Superoxide Dismutase; Tunica Intima; Tyrosine | 2004 |
Pulmonary MnSOD is nitrated following hepatic ischemia-reperfusion.
Topics: Animals; Biomarkers; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Ischemia; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Reperfusion; Reperfusion Injury; Respiratory Distress Syndrome; Sensitivity and Specificity; Severity of Illness Index; Superoxide Dismutase; Tyrosine | 2004 |
Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Confocal; Neurons; Nitric Oxide; Nitric Oxide Synthase; Plaque, Amyloid; Tyrosine | 2004 |
Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Inositol 1,4,5-Trisphosphate Receptors; Male; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; src-Family Kinases; Tyrosine | 2004 |
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
Topics: Animals; Antioxidants; Disease Models, Animal; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Transgenic; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-myc; Transforming Growth Factor alpha; Tyrosine; Vitamin E | 2004 |
Activation of ubiquitin-proteasome pathway is involved in skeletal muscle wasting in a rat model with biliary cirrhosis: potential role of TNF-alpha.
Topics: Animals; Blotting, Western; Body Weight; Calpain; Cathepsins; Disease Models, Animal; Gene Expression; Ligation; Liver; Liver Cirrhosis, Biliary; Male; Methylhistidines; Muscle Proteins; Muscle, Skeletal; Myofibrils; NF-kappa B; Nuclear Proteins; Proteasome Endopeptidase Complex; Protein Subunits; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2005 |
Differential effects of exercise on aortic mitochondria.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Cholesterol; Disease Models, Animal; Hypercholesterolemia; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mitochondria; Mitochondrial ADP, ATP Translocases; Oxidative Stress; Physical Exertion; Risk Factors; Tyrosine | 2005 |
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.
Topics: Aging; Animals; Apoptosis; Apoptosis Inducing Factor; Autophagy; Brain Injuries; Calpain; Caspase 3; Caspases; Cell Death; Cytochromes c; Disease Models, Animal; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondria; Necrosis; Neurons; Protein Transport; Tyrosine | 2005 |
Effect of methylguanidine in a model of septic shock induced by LPS.
Topics: Animals; Cell Line; Cell Survival; Disease Models, Animal; Lipopolysaccharides; Lung; Macrophages; Male; Methylguanidine; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Shock, Septic; Survival Rate; Tyrosine | 2004 |
Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy.
Topics: Actins; Animals; Carrier Proteins; Cell Line; Coronary Vessels; Detergents; Disease Models, Animal; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Immunohistochemistry; Immunosuppressive Agents; Kidney; Kidney Diseases; Macaca mulatta; Mass Spectrometry; Muscle, Smooth; Nephritis; Phosphoproteins; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Selenium-Binding Proteins; Transforming Growth Factor beta; Tyrosine; Uterus | 2005 |
Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Cell Count; Disease Models, Animal; Disease Progression; Gliosis; Lumbosacral Region; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pioglitazone; PPAR gamma; Psychomotor Performance; Spinal Cord; Superoxide Dismutase; Survival Rate; Thiazolidinediones; Tyrosine; Weight Loss | 2005 |
Age-dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells.
Topics: Age Factors; Animals; Antigens, Differentiation; Brain; Caspase 3; Caspases; Cell Count; Dentate Gyrus; Disease Models, Animal; Female; Functional Laterality; Lateral Ventricles; Male; Myelin Sheath; Particle Accelerators; Radiation Injuries, Experimental; Radiation Tolerance; Rats; Rats, Wistar; Stem Cells; Tumor Suppressor Protein p53; Tyrosine | 2005 |
Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidoreductase in vivo.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Cell Nucleus; Disease Models, Animal; Gliosis; Light; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Neurons; Oxidoreductases; Phosphorylation; Photic Stimulation; Photoreceptor Cells; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Tyrosine; WW Domain-Containing Oxidoreductase | 2005 |
Astroglial nitration after postnatal excitotoxic damage: correlation with nitric oxide sources, cytoskeletal, apoptotic and antioxidant proteins.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cytoskeletal Proteins; Disease Models, Animal; Female; Male; Metallothionein; Nerve Tissue Proteins; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Long-Evans; Superoxide Dismutase; Tyrosine | 2005 |
FK419, a novel nonpeptide GPIIb/IIIa antagonist, restores microvascular patency and improves outcome in the guinea-pig middle cerebral artery thrombotic occlusion model: comparison with tirofiban.
Topics: Animals; Blood Platelets; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Infarction, Middle Cerebral Artery; Intracranial Thrombosis; Male; Microcirculation; Neutrophils; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Propionates; Recovery of Function; Reperfusion Injury; Tirofiban; Tyrosine | 2005 |
Effects of antioxidant vitamin supplements on Helicobacter pylori-induced gastritis in Mongolian gerbils.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Ascorbic Acid; Deoxyguanosine; Dietary Supplements; Disease Models, Animal; Gastric Mucosa; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Stomach Neoplasms; Thiobarbituric Acid Reactive Substances; Tyrosine; Vitamin E; Vitamins | 2005 |
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Focal Adhesion Kinase 2; Hippocampus; Lithium; Male; Muscarinic Agonists; Neurons; Phosphorylation; Pilocarpine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Serine; src-Family Kinases; Status Epilepticus; Tyrosine | 2005 |
Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse.
Topics: Animals; Apoptosis; Arthritis, Experimental; Cartilage, Articular; Chemokines; Chondrocytes; Cytokines; Disease Models, Animal; Erythropoietin; Hematinics; Injections, Subcutaneous; Mice; Mice, Inbred DBA; Neutrophil Infiltration; Poly(ADP-ribose) Polymerases; Tyrosine | 2005 |
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.
Topics: Animals; Aorta, Thoracic; Biopterins; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoprostanes; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Protein Subunits; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2005 |
Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease.
Topics: Acetylcholine; Afferent Pathways; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Denervation; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Presynaptic Terminals; Serotonin; Superoxide Dismutase; Tyrosine; Wallerian Degeneration | 2005 |
Role of oxidative stress in the pathogenesis of septic ileus in mice.
Topics: Aldehydes; Animals; Antioxidants; Catalase; Disease Models, Animal; Gastric Emptying; Gastrointestinal Transit; Ileus; Immunohistochemistry; Intestinal Mucosa; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Sepsis; Superoxide Dismutase; Tyrosine | 2005 |
Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion.
Topics: Analysis of Variance; Animals; Anticoagulants; Biomarkers; Blood Platelets; Brain Ischemia; Disease Models, Animal; Flow Cytometry; Inflammation; Leukocytes; Male; Myocardial Reperfusion Injury; Neutrophil Activation; Neutrophils; Platelet Aggregation; Platelet Aggregation Inhibitors; Polysaccharides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Severity of Illness Index; Stroke; Time Factors; Tirofiban; Tyrosine | 2005 |
Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats.
Topics: Adaptation, Physiological; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation; Glucose; In Vitro Techniques; Insulin Resistance; Male; Myocardial Contraction; Myocardium; Oxazoles; PPAR gamma; Rats; Rats, Inbred Strains; Rats, Zucker; Signal Transduction; Transcriptional Activation; Triglycerides; Tyrosine | 2005 |
Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.
Topics: Amyloid beta-Peptides; Animals; Biomarkers; Brain; Disease Models, Animal; Encephalitis; Genetic Predisposition to Disease; Gliosis; Humans; Injections, Intraventricular; Mice; Mice, Knockout; Mice, Transgenic; Nerve Degeneration; Nerve Growth Factors; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine | 2005 |
Activation of caspase-3 is associated with oxidative stress in the hydropic guinea pig cochlea.
Topics: Animals; Apoptosis; Audiometry; Caspase 3; Caspases; Cochlea; Cochlear Diseases; Dinoprost; Disease Models, Animal; Endolymphatic Hydrops; Enzyme Activation; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Immunohistochemistry; Meniere Disease; Oxidative Stress; Spiral Ganglion; Staining and Labeling; Tyrosine | 2005 |
Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus.
Topics: Animals; Blotting, Western; Brain Ischemia; Disease Models, Animal; Focal Adhesion Kinase 2; Hippocampus; Immunoprecipitation; Male; Neural Inhibition; Oligodeoxyribonucleotides, Antisense; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Tyrosine | 2005 |
Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model.
Topics: Animals; Boron Compounds; Brain; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glioma; Glycopeptides; Metabolic Clearance Rate; Molecular Probe Techniques; Organ Specificity; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tissue Distribution; Tyrosine | 2005 |
Thalidomide treatment reduces colon injury induced by experimental colitis.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Immunohistochemistry; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-1; Mice; Neutrophils; Peroxidase; Poly Adenosine Diphosphate Ribose; Thalidomide; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A | 2005 |
Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.
Topics: Aging; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Female; Humans; Inclusion Bodies; Male; Mice; Mice, Transgenic; Mutation, Missense; Nerve Degeneration; Neurons; Phosphorylation; Protein Isoforms; tau Proteins; Tauopathies; Tyrosine; Up-Regulation | 2005 |
Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport.
Topics: Animals; Cell Respiration; Disease Models, Animal; Electron Transport Complex IV; Male; Mice; Mice, Knockout; Myocardial Ischemia; NADH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type III; Oximetry; Oxygen; Oxygen Consumption; Tyrosine; Up-Regulation | 2005 |
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation | 2005 |
Early administration of a second-generation perfluorochemical decreases ischemic brain damage in a model of permanent middle cerebral artery occlusion in the rat.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Drug Therapy, Combination; Fluorocarbons; Immunohistochemistry; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Necrosis; Neuroprotective Agents; Oxygen; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Silver Staining; Time Factors; Tyrosine | 2005 |
Photoreceptor mitochondrial tyrosine nitration in experimental uveitis.
Topics: Amino Acid Sequence; Animals; Autoimmune Diseases; Blotting, Western; Cytochromes c; Disease Models, Animal; Immunoenzyme Techniques; Mass Spectrometry; Mitochondrial Proteins; Molecular Chaperones; Molecular Sequence Data; Nitrosation; Peroxynitrous Acid; Phosphoglycerate Mutase; Photoreceptor Cells, Vertebrate; Rats; Rats, Inbred Lew; Retina; Spectrophotometry, Ultraviolet; Tyrosine; Uveitis | 2005 |
The effect of tirofiban on microvascular thrombosis: crush model.
Topics: Anastomosis, Surgical; Animals; Disease Models, Animal; Femoral Artery; Isotonic Solutions; Microsurgery; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Random Allocation; Rats; Rats, Sprague-Dawley; Ringer's Lactate; Thrombosis; Tirofiban; Tyrosine; Vascular Patency | 2005 |
Reactive nitrogen species formation in eosinophils and imbalance in nitric oxide metabolism are involved in atopic dermatitis-like skin lesions in NC/Nga mice.
Topics: Allergens; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Dermatitis, Atopic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Immunoglobulin E; Immunohistochemistry; Isoenzymes; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrogen; Reactive Oxygen Species; Tyrosine | 2005 |
Pathologic and immunohistochemical findings in hypothalamic and mesencephalic regions in the pah(enu2) mouse model for phenylketonuria.
Topics: Animals; Catecholamines; CD11b Antigen; Disease Models, Animal; Dopamine; Female; Gene Transfer Techniques; Genotype; Heterozygote; Homozygote; Hypothalamus; Immunohistochemistry; Macrophages; Male; Mesencephalon; Mice; Mice, Mutant Strains; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenylketonurias; Substantia Nigra; Time Factors; Tryptophan; Tyrosine | 2005 |
Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III).
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Southern; Brain Injuries; Caspase 3; Caspases; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Agar Gel; gamma-Aminobutyric Acid; Huntington Disease; Lipid Peroxidation; Male; Mitochondria; Motor Activity; Nitric Oxide Synthase; Peroxynitrous Acid; Porphyrins; Quinolinic Acids; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Rotarod Performance Test; Superoxide Dismutase; Synaptic Vesicles; Synaptosomes; Tyrosine | 2005 |
Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Female; Functional Laterality; Gene Expression Regulation; Hypoxia-Ischemia, Brain; Imino Pyranoses; Immunohistochemistry; Male; Nitric Oxide Synthase; Piperidines; Rats; Statistics, Nonparametric; Time Factors; Tyrosine | 2005 |
Poly (ADP) ribose polymerase inhibition improves rat cardiac allograft survival.
Topics: Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Graft Survival; Heart Transplantation; Indoles; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Lew; Tyrosine | 2005 |
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.
Topics: Adrenergic Agents; Aldehydes; alpha-Synuclein; Animals; Behavior, Animal; Blotting, Western; CD11b Antigen; Cell Count; Cell Line; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Functional Laterality; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Neurodegenerative Diseases; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Parkinsonian Disorders; Rats; Rats, Wistar; Reactive Oxygen Species; Rotarod Performance Test; Rotation; Substantia Nigra; Synaptophysin; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Inhibition of nitric oxide synthase reduces renal ischemia/reperfusion injury.
Topics: Amidines; Animals; Benzylamines; Creatinine; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Kidney Tubules; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine | 2005 |
Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Chronic Disease; Cysteine; Disease Models, Animal; Female; Fetus; Free Radical Scavengers; Lung; Lung Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Papio; Pregnancy; S-Nitrosothiols; Tyrosine | 2005 |
Effects of NH4Cl intake on renal growth in rats: role of MAPK signalling pathway.
Topics: Acidosis, Renal Tubular; Ammonium Chloride; Animals; Blotting, Western; Disease Models, Animal; Hypertrophy; Hypoglycemic Agents; Insulin; Kidney; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Sodium; Tyrosine | 2005 |
Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Graft Rejection; Heart Transplantation; Lysine; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Inbred Lew; Rats, Inbred WF; Superoxide Dismutase; Tyrosine | 2005 |
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzoquinones; Blotting, Western; Brain; Cell Death; Cell Nucleus; Cytosol; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Dopamine Agents; Enzyme Inhibitors; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Immunohistochemistry; Lactams, Macrocyclic; Male; Mice; Mice, Inbred C57BL; Models, Biological; Molecular Chaperones; Neoplasm Proteins; Neurons; Neurotoxins; Parkinson Disease; Quinones; Time Factors; Transcription Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
In vivo genetic selection of renal proximal tubules.
Topics: Acute Disease; Animals; Bone Marrow Transplantation; Cell Differentiation; Cell Fusion; Chronic Disease; Disease Models, Animal; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hydrolases; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Knockout; Necrosis; Regeneration; Tyrosine; Urothelium | 2006 |
Increased oxidative-related mechanisms in the spinal cord injury in old rats.
Topics: Age Factors; Analysis of Variance; Animals; Disease Models, Animal; Immunohistochemistry; Laminectomy; Male; Oxidation-Reduction; Peroxidase; Poly Adenosine Diphosphate Ribose; Rats; Spinal Cord Injuries; Time Factors; Tyrosine | 2006 |
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Brain Chemistry; Caspase 3; Caspases; Cholinergic Fibers; Disease Models, Animal; Immunohistochemistry; Memory Disorders; Mice; Mice, Transgenic; Pedunculopontine Tegmental Nucleus; REM Sleep Behavior Disorder; Tyrosine | 2005 |
Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death.
Topics: Animals; Cardiopulmonary Resuscitation; Disease Models, Animal; Dogs; Female; Heart Arrest; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Neurons; Oxidative Stress; Oxygen; Oxygen Inhalation Therapy; Pyruvate Dehydrogenase Complex; Tyrosine | 2006 |
Extracellular superoxide dismutase and oxidant damage in osteoarthritis.
Topics: Adult; Aged; Animals; Cartilage, Articular; Disease Models, Animal; Female; Femur Head; Free Radical Scavengers; Hindlimb; Humans; Male; Mice; Mice, Inbred CBA; Nitric Oxide Synthase; Osteoarthritis, Hip; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tibia; Tyrosine | 2005 |
A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury.
Topics: Alcoholic Intoxication; Animals; Binding Sites; Burns; Cytokines; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Ethanol; Immune Tolerance; Lymph Nodes; Male; MAP Kinase Signaling System; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; T-Lymphocytes; Threonine; Tyrosine | 2006 |
In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Brain; Bridged-Ring Compounds; Disease Models, Animal; Free Radicals; Gerbillinae; Lipid Peroxidation; Male; Nerve Degeneration; Neurons; Norbornanes; Oxidative Stress; Peptide Fragments; Reactive Oxygen Species; Synaptosomes; Thiocarbamates; Thiones; Type C Phospholipases; Tyrosine | 2006 |
Tyrphostin AG 126 reduces intestinal ischemia-reperfusion injury in the rat.
Topics: Animals; Blood Pressure; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-1beta; Intestines; Lipid Peroxidation; Male; Mesenteric Artery, Superior; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2006 |
Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection.
Topics: Animals; Arginine; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Interleukin-1; Interleukin-6; Lung; Lung Diseases; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pseudomonas Infections; Rats; Rats, Inbred WKY; Tyrosine; Vascular Endothelial Growth Factor A | 2006 |
Iodination of tyrosyls in thyroglobulin generates neoantigenic determinants that cause thyroiditis.
Topics: Amino Acid Sequence; Animals; Antibodies; Antigens; Disease Models, Animal; Female; Iodine; Mice; Molecular Sequence Data; Peptide Fragments; Protein Binding; Thyroglobulin; Thyroiditis, Autoimmune; Tyrosine | 2006 |
Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Activation; Focal Adhesion Kinase 2; Guanine Nucleotide Exchange Factors; Hippocampus; Lithium; Male; Phosphorylation; Pilocarpine; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Status Epilepticus; Time Factors; Tyrosine | 2006 |
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Myeloproliferative Disorders; Protein Structure, Tertiary; Signal Transduction; STAT5 Transcription Factor; Tyrosine | 2006 |
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Cortex; Disease Models, Animal; Homozygote; Mice; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Oxidative Stress; Respiration; Superoxide Dismutase; Tyrosine | 2006 |
Effect of partial bladder outlet obstruction on nitrotyrosine levels and their correlation with contractile function.
Topics: Animals; Disease Models, Animal; Free Radicals; Male; Muscle Contraction; Muscle, Smooth; Organ Size; Rabbits; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2006 |
Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury.
Topics: Acute Disease; alpha-Tocopherol; Animals; Antioxidants; Burns; Disease Models, Animal; Extravascular Lung Water; gamma-Tocopherol; Lipids; Lung; Lung Injury; Pulmonary Gas Exchange; Pulmonary Wedge Pressure; Sheep; Smoke Inhalation Injury; Tyrosine | 2006 |
Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency.
Topics: Actins; alpha-Crystallin A Chain; Animals; Arginine; Cataract; Chromosome Mapping; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Epithelial Cells; Female; Genes, Dominant; Genes, Recessive; Genetic Linkage; Green Fluorescent Proteins; Lens, Crystalline; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mitochondria; Phenotype; Point Mutation; Tyrosine | 2006 |
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism.
Topics: Animals; Arginase; Atherosclerosis; Bromodeoxyuridine; Cell Movement; Disease Models, Animal; Estradiol; Female; Gene Expression Regulation, Enzymologic; Hyperlipidemias; Immunohistochemistry; Lipids; Macrophages; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Rabbits; Tyrosine | 2006 |
Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.
Topics: Aldehydes; Animals; Antipyrine; Apolipoproteins E; Apoptosis; Atherosclerosis; Cells, Cultured; Cholesterol, Dietary; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Endothelial Cells; Free Radical Scavengers; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2007 |
Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis.
Topics: Airway Obstruction; Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Female; Fibrinolytic Agents; Infusions, Intravenous; Lung; Nitrates; Nitrites; Organ Size; Prospective Studies; Protein C; Pulmonary Edema; Random Allocation; Recombinant Proteins; Respiratory Function Tests; Sepsis; Sheep; Smoke Inhalation Injury; Tyrosine | 2006 |
A model for the pharmacological treatment of crouzon syndrome.
Topics: Animals; Cranial Sutures; Craniofacial Dysostosis; Cysteine; Disease Models, Animal; Mice; Mice, Mutant Strains; Mutation; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Tissue Culture Techniques; Tomography, X-Ray Computed; Tyrosine | 2006 |
Electromyographic findings in nucleus pulposus-induced radiculopathy in the rat.
Topics: Animals; Disease Models, Animal; Electromyography; Fluorescent Antibody Technique, Indirect; Ganglia, Spinal; Hyperalgesia; Immunoenzyme Techniques; Intervertebral Disc; Male; Muscle, Skeletal; Paresis; Radiculopathy; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Tyrosine | 2006 |
Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Disease Models, Animal; Gene Deletion; Guanidines; Humans; Hydrogen Peroxide; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Pyruvate Oxidase; Streptococcus pneumoniae; Tyrosine | 2006 |
Brain injury following repetitive apnea in newborn piglets.
Topics: Animals; Animals, Newborn; Apnea; Brain; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine; Neurons; Recurrence; Swine; Tyrosine | 2006 |
Gastric expression of inducible nitric oxide synthase and myeloperoxidase in relation to nitrotyrosine in Helicobacter pylori-infected Mongolian gerbils.
Topics: Animals; Blotting, Western; Disease Models, Animal; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Nitric Oxide Synthase Type II; Peroxidase; Pyloric Antrum; Pylorus; Rats; Severity of Illness Index; Tyrosine | 2006 |
Effects of acute hypobaric hypoxia on the nitric oxide system of the rat cerebral cortex: Protective role of nitric oxide inhibitors.
Topics: Altitude; Analysis of Variance; Animals; Blotting, Western; Calcium; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Hypoxia; Immunohistochemistry; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine | 2006 |
Neuroprotection by selective inhibition of inducible nitric oxide synthase after experimental brain contusion.
Topics: Animals; Apoptosis; Brain Injuries; Cell Survival; Disease Models, Animal; Female; Lysine; Nerve Degeneration; Neurons; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Deoxyguanosine; Disease Models, Animal; Fatty Acids, Nonesterified; Hypertension; Inflammation; Insulin; Male; Metabolic Syndrome; Molecular Structure; Musa; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Inbred SHR; Thiobarbituric Acid Reactive Substances; Triglycerides; Triterpenes; Tyrosine | 2006 |
Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.
Topics: Aldehydes; Animals; Antioxidants; Bisoprolol; Blood Pressure; Body Weight; Cardiomyopathy, Dilated; Cricetinae; Disease Models, Animal; Echocardiography; Fibrosis; Glutathione; Heart Failure; Heart Rate; Interleukin-1; Isoenzymes; Male; NADPH Oxidases; Organ Size; Oxidative Stress; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Ventricular Function, Left | 2006 |
Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice.
Topics: Animals; Biomarkers, Tumor; Blood Proteins; Cell Line, Tumor; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gelsolin; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Prostatic Neoplasms; Proteomics; Transplantation, Heterologous; Tyrosine | 2006 |
Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Fas Ligand Protein; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Motor Neurons; Nitric Oxide Synthase Type I; Probability; Spinal Cord; Superoxide Dismutase; Survival Analysis; Tyrosine | 2006 |
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease.
Topics: Aldehydes; Alzheimer Disease; Animals; Antioxidants; Behavior Therapy; Behavior, Animal; Brain; Disease Models, Animal; Dogs; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Glutathione Transferase; Heme Oxygenase-1; Proteomics; Superoxide Dismutase; Tyrosine | 2008 |
The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy.
Topics: Animals; Astrocytes; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Hepatic Encephalopathy; Immunohistochemistry; Male; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Disease Models, Animal; Female; Gene Expression Regulation; Male; Methyl-CpG-Binding Protein 2; Methylation; Mice; Mice, Transgenic; Mutation; Promoter Regions, Genetic; Protein Binding; Rett Syndrome; Stress, Physiological; Transcription, Genetic; Tyrosine | 2006 |
Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, Animal; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Isoleucine; Magnetic Resonance Imaging; Maze Learning; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Psychomotor Performance; Tyrosine | 2008 |
Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Fetus; HSP90 Heat-Shock Proteins; Humans; Infant, Newborn; Ligation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidative Stress; Persistent Fetal Circulation Syndrome; Pregnancy; Pulmonary Artery; S-Nitroso-N-Acetylpenicillamine; Sheep; Superoxides; Tyrosine; Vasodilation | 2007 |
Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Disease Models, Animal; Disease Progression; Gliosis; Mice; Mice, Transgenic; Psychomotor Performance; Pyruvic Acid; Spinal Cord; Superoxide Dismutase; Survival Analysis; Tyrosine | 2007 |
Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase.
Topics: Animals; Disease Models, Animal; Kidney; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury; Tyrosine; Xanthine Dehydrogenase | 2007 |
The nitric oxide donor LA 419 decreases ischemic brain damage.
Topics: Animals; Brain Ischemia; Calcium; Disease Models, Animal; Immunohistochemistry; Isosorbide Dinitrate; Magnetic Resonance Imaging; Male; Neurons; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 2007 |
The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model.
Topics: Animals; Brain Injuries; Corpus Striatum; Disease Models, Animal; Ischemia; Isosorbide Dinitrate; Magnetic Resonance Imaging; Male; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine | 2007 |
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice.
Topics: Ambrosia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cyclic AMP; Disease Models, Animal; I-kappa B Proteins; Leukocytes; Lipid Peroxidation; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Mice, Knockout; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Phosphorylation; Plethysmography, Whole Body; Pneumonia; Reactive Nitrogen Species; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tyrosine | 2007 |
Role of oxidative stress on pathogenesis of hypertensive cerebrovascular lesions.
Topics: Aldehydes; Animals; Arterioles; Brain; Brain Edema; Cerebral Hemorrhage; Cerebrovascular Disorders; Disease Models, Animal; Endothelium, Vascular; Hypertension; Intracranial Arterial Diseases; Male; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroblue Tetrazolium; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine; Up-Regulation | 2007 |
Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Dietary Fats; Disease Models, Animal; Enzyme Inhibitors; Farnesyltranstransferase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Oxidative Stress; Phosphorylation; Polyenes; Polyunsaturated Alkamides; Protein Prenylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sinus of Valsalva; Superoxides; Time Factors; Tyrosine | 2007 |
Which comes first: renal inflammation or oxidative stress in spontaneously hypertensive rats?
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Age Factors; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Deoxyguanosine; Disease Models, Animal; Disease Progression; DNA Damage; Glutathione; Hypertension; Kidney Cortex; Male; NADPH Oxidases; Nephritis; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Tyrosine | 2007 |
Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death.
Topics: Animals; Blood Pressure; Brain Death; Cyclic GMP-Dependent Protein Kinases; Diamines; Disease Models, Animal; Ditiocarb; Enzyme Induction; Heart Rate; Male; Medulla Oblongata; Mevinphos; Muscarinic Antagonists; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Reproducibility of Results; Thiocarbamates; Time Factors; Transcription, Genetic; Tropicamide; Tyrosine | 2007 |
[Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn].
Topics: Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Burns; Dimethyl Sulfoxide; Disease Models, Animal; Female; Glucose Clamp Technique; Immunohistochemistry; Injections, Intravenous; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Muscles; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Serine; Tyrosine | 2007 |
Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock.
Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Ceftazidime; Disease Models, Animal; Female; Heart Rate; Hemodynamics; Lung; Nitrates; Nitrites; Oxygen Consumption; Random Allocation; Sheep; Shock, Septic; Smoke Inhalation Injury; Tyrosine | 2007 |
Endotoxemia produces coma and brain swelling in bile duct ligated rats.
Topics: Ammonia; Animals; Brain; Brain Edema; Capillaries; Cholestasis, Extrahepatic; Coma; Consciousness; Cytokines; Disease Models, Animal; Endotoxemia; Hyperammonemia; Ligation; Lipopolysaccharides; Liver Cirrhosis, Experimental; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley; Tyrosine | 2007 |
Nitrotyrosylation of Ca2+ channels prevents c-Src kinase regulation of colonic smooth muscle contractility in experimental colitis.
Topics: Animals; Calcium; Calcium Channels; Colitis; Colon; CSK Tyrosine-Protein Kinase; Disease Models, Animal; Electrophysiology; Humans; Inflammation; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Nitric Acid; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine | 2007 |
Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection.
Topics: Acute Disease; Animals; Bilirubin; Biomarkers; Blotting, Western; Dipyrone; Disease Models, Animal; Disease Progression; Free Radical Scavengers; Graft Rejection; Heart Transplantation; Heme Oxygenase-1; Immunohistochemistry; Myocardium; Nitric Oxide; Oxidation-Reduction; Prognosis; Rats; Transplantation, Homologous; Tyrosine | 2007 |
Temporal characterization of mitochondrial bioenergetics after spinal cord injury.
Topics: Aldehydes; Animals; Disease Models, Animal; Disease Progression; Energy Metabolism; Female; Free Radicals; Lipid Peroxidation; Mitochondria; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spinal Cord; Spinal Cord Injuries; Time Factors; Tyrosine | 2007 |
Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice.
Topics: Animals; Aorta; Apolipoprotein A-I; Atherosclerosis; Autoantibodies; Blood Coagulation; Blood Proteins; Cholesterol, HDL; Disease Models, Animal; Female; Fibrin; Fibrinogen; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Nitrogen; Oxidants; Proteomics; Tyrosine | 2007 |
FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms.
Topics: Animals; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glutathione Peroxidase; Immunohistochemistry; Male; Nerve Regeneration; Nitric Oxide Synthase; Penile Erection; Penis; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tacrolimus; Tyrosine; Vasodilator Agents | 2007 |
Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Coronary Circulation; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Free Radicals; Heterocyclic Compounds, 3-Ring; Immunohistochemistry; Isoenzymes; Mice; Mice, Transgenic; Mitochondria, Heart; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrometry, Fluorescence; Time Factors; Tyrosine; Ventricular Function, Left; Ventricular Pressure | 2007 |
Effects of plant alkylphenols on cytokine production, tyrosine nitration and inflammatory damage in the efferent phase of contact hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Blotting, Western; Chlorogenic Acid; Dermatitis, Contact; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Glucosides; Hydroquinones; Interleukin-1beta; Interleukin-4; Mice; Neutrophils; Nitric Oxide Synthase Type II; Random Allocation; Skin; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Beneficial effects of FeTSPP, a peroxynitrite decomposition catalyst, in a mouse model of spinal cord injury.
Topics: Animals; Catalysis; Disease Models, Animal; DNA; I-kappa B Proteins; Interleukin-1beta; Interleukin-2; Lipid Peroxidation; Male; Metalloporphyrins; Mice; Mitochondria; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; RNA; Spinal Cord Injuries; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
Topics: Animals; Animals, Genetically Modified; Aorta; Apolipoprotein A-I; Betaine; Cholesterol; Disease Models, Animal; Fatty Liver; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Lipotropic Agents; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Time; Triglycerides; Tyrosine | 2007 |
Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark.
Topics: Adaptation, Ocular; Animals; Aspartic Acid; Calcium; Cyclic GMP; Cysteine; Dark Adaptation; Disease Models, Animal; Electroretinography; Gene Expression Regulation; Glycine; Guanylate Cyclase-Activating Proteins; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Physical Stimulation; Retina; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Rhodopsin; Tyrosine | 2007 |
Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function.
Topics: Animals; Body Weight; Disease Models, Animal; Glycation End Products, Advanced; Glyoxal; Kidney Failure, Chronic; Ligation; Male; Nephrectomy; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Wistar; Tyrosine | 2007 |
Mouse models of diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; DNA Fragmentation; Hyperalgesia; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred NOD; Nerve Fibers; Neural Conduction; Pain Measurement; Reaction Time; Streptozocin; Tyrosine; Ubiquitin Thiolesterase | 2007 |
STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.
Topics: Animals; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Butadienes; Capillaries; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Drug Synergism; Embryonic Stem Cells; Enzyme Inhibitors; Leukemia Inhibitory Factor; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocytes, Cardiac; Nitriles; Phosphorylation; Serine; Signal Transduction; STAT3 Transcription Factor; Stem Cell Transplantation; Transforming Growth Factor beta; Triterpenes; Tyrosine | 2007 |
Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis.
Topics: Animals; Disease Models, Animal; Female; Hematocrit; Hemodynamics; Lung; Methicillin; Methicillin Resistance; Pneumonia; Sepsis; Sheep; Smoke Inhalation Injury; Staphylococcus aureus; Time Factors; Tyrosine | 2008 |
Cardioplegia and diazoxide modulate STAT3 activation and DNA binding.
Topics: Animals; Apoptosis; Binding Sites; Blotting, Western; Cardioplegic Solutions; Diazoxide; Disease Models, Animal; DNA; Electrophoresis; Female; Heart Arrest, Induced; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Phosphorylation; Random Allocation; Sensitivity and Specificity; STAT3 Transcription Factor; Swine; Tyrosine | 2007 |
Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis.
Topics: Adult; Aged; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; CD3 Complex; Cells, Cultured; Chemotaxis, Leukocyte; CpG Islands; Cytokines; Disease Models, Animal; DNA Methylation; Ephrin-B1; Female; Fibroblasts; Humans; Interleukin-6; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Middle Aged; Osteoarthritis; Phosphorylation; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; Synovial Membrane; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Combination of dexamethasone and etanercept reduces secondary damage in experimental spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Etanercept; Immunoglobulin G; In Situ Nick-End Labeling; Interleukin-1beta; Laminectomy; Male; Mice; Neutrophils; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Spinal Cord Injuries; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Apoptosis; Baclofen; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Agents; In Situ Nick-End Labeling; Male; Muscimol; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Reperfusion; src-Family Kinases; Tyrosine | 2007 |
Nitric oxide bioavailability and not production is first altered during the onset of insulin resistance in sucrose-fed rats.
Topics: Animals; Aorta; Biomarkers; Cyclic GMP; Cysteine; Diet; Diet Therapy; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Insulin Resistance; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Sucrose; Sweetening Agents; Tyrosine | 2007 |
Resuscitation of hypoxic newborn piglets with oxygen induces a dose-dependent increase in markers of oxidation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Animals, Newborn; Biomarkers; Chromatography, High Pressure Liquid; Deoxyguanosine; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Female; Hypoxia; Male; Oxidative Stress; Oxygen; Oxygen Inhalation Therapy; Phenylalanine; Reactive Oxygen Species; Respiration, Artificial; Swine; Tandem Mass Spectrometry; Time Factors; Tyrosine | 2007 |
Selective iNOS inhibition reduces renal damage induced by cisplatin.
Topics: Aldehydes; Amidines; Animals; Antineoplastic Agents; Benzylamines; Cisplatin; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kidney; Kidney Diseases; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2008 |
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
Topics: Actins; Animals; Blood Pressure; Cell Movement; Collagen Type IV; Creatinine; Disease Models, Animal; Hypertension; Hypertrophy; Inflammation; Kidney; Kidney Failure, Chronic; Leukocytes; Male; Malondialdehyde; Melatonin; Nephrectomy; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Transforming Growth Factor beta; Tyrosine | 2008 |
Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antipsychotic Agents; Anxiety; Brain; Dibenzothiazepines; Disease Models, Animal; Female; Male; Memory Disorders; Mice; Mice, Transgenic; Plaque, Amyloid; Presenilin-1; Protease Nexins; Proto-Oncogene Proteins c-bcl-2; Quetiapine Fumarate; Receptors, Cell Surface; Tyrosine | 2009 |
How DMSO, a widely used solvent, affects spinal cord injury.
Topics: Animals; Aorta, Abdominal; Dimethyl Sulfoxide; Disease Models, Animal; Free Radical Scavengers; Ligation; Malondialdehyde; Neuroprotective Agents; Nitrates; Nitrites; Peroxidase; Rabbits; Reperfusion Injury; Solvents; Spinal Cord; Spinal Cord Ischemia; Time Factors; Tyrosine | 2008 |
Anti-tumor effects of liposome-encapsulated titanium dioxide in nude mice.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Liposomes; Male; Mice; Mice, Nude; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Titanium; Tyrosine; Urinary Bladder Neoplasms | 2007 |
Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Chlorogenic Acid; Disease Models, Animal; Endothelium, Vascular; Heart Rate; Hydrogen Peroxide; Hydroquinones; Hypertension; Immunohistochemistry; Male; Nitric Oxide; Nitroprusside; Quinic Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2008 |
Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus.
Topics: Animals; Brain Injuries; Disease Models, Animal; Hippocampus; Male; Oxidative Stress; Oxygen Inhalation Therapy; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resuscitation; Tyrosine | 2008 |
Effect of platelet glycoprotein IIb/IIIa receptor antagonist on survival of epigastric island flaps in rats with total venous occlusions.
Topics: Abdominal Wall; Animals; Disease Models, Animal; Graft Survival; Laser-Doppler Flowmetry; Male; Necrosis; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Surgical Flaps; Tirofiban; Tyrosine; Venous Insufficiency | 2008 |
Attenuation of vascular/neural dysfunction in Zucker rats treated with enalapril or rosuvastatin.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Cardiovascular System; Disease Models, Animal; Enalapril; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metabolic Syndrome; Motor Neurons; Neural Conduction; Neurons, Afferent; Nociceptors; Obesity; Peripheral Nerves; Pyrimidines; Rats; Rats, Zucker; Rosuvastatin Calcium; Sciatic Nerve; Sulfonamides; Superoxides; Tyrosine; Vasodilator Agents | 2008 |
The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Fertility; Hydrolases; Intestines; Mutation; Oxidative Stress; Phenotype; Protein Folding; RNA Interference; Tyrosine; Tyrosinemias | 2008 |
Kidney damage after renal ablation is worsened in endothelial nitric oxide synthase -/- mice and improved by combined administration of L-arginine and antioxidants.
Topics: Animals; Antioxidants; Arginine; Blood Pressure; Disease Models, Animal; Drug Combinations; Kidney; Kidney Failure, Chronic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteinuria; Superoxides; Time Factors; Tyrosine | 2008 |
On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.
Topics: Analysis of Variance; Animals; Antimetabolites; Area Under Curve; Body Temperature; Brain; Catechols; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Isoxazoles; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Nitriles; Protein Binding; Rats; Rats, Wistar; Serotonin; Time Factors; Tyrosine | 2008 |
Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats.
Topics: Animals; Behavior, Animal; Blood Glucose; Body Weight; Brain; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Muscle, Skeletal; Pain Measurement; Pain Threshold; Phosphorylation; Rats; Rats, Wistar; Receptor, Insulin; Sciatic Nerve; Signal Transduction; Streptozocin; Time Factors; Tyrosine | 2008 |
A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Brain; Cell Respiration; Cells, Cultured; Disease Models, Animal; Humans; Membrane Potential, Mitochondrial; Metalloporphyrins; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Mutation; Neurons; Oxidative Stress; Presenilin-1; Protein Carbonylation; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2008 |
Alcohol-induced oxidative stress in the liver: in vivo measurements.
Topics: Aldehydes; Animals; Biomarkers; Disease Models, Animal; Immunohistochemistry; Lipopolysaccharides; Liver; Liver Diseases, Alcoholic; Mice; Mice, Transgenic; Oxidative Stress; Photomicrography; Proteins; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Reproducibility of Results; Signal Processing, Computer-Assisted; Specimen Handling; Tyrosine | 2008 |
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
Topics: Animals; Benzophenones; Chromatography, High Pressure Liquid; Disease Models, Animal; Glioma; Molecular Conformation; Nickel; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Wistar; Schiff Bases; Skin Neoplasms; Stereoisomerism; Tyrosine | 2008 |
Application of normobaric hyperoxia therapy for amelioration of haemorrhagic shock-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Creatinine; Cystatin C; Cystatins; Dinoprostone; Disease Models, Animal; Hyperoxia; Kidney; Male; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Shock, Hemorrhagic; Transcription Factor RelA; Tyrosine; Urea | 2008 |
p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
Topics: Abdomen; Animals; Calmodulin; Cardiotonic Agents; Caveolin 1; Chemokine CXCL1; Chemokine CXCL2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Estradiol; Heart Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Mitogen-Activated Protein Kinase 11; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Ventricular Function | 2008 |
Effects of postresuscitation N-acetylcysteine on cerebral free radical production and perfusion during reoxygenation of hypoxic newborn piglets.
Topics: Acetylcysteine; Animals; Animals, Newborn; Carotid Arteries; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; Lactates; Nitric Oxide; Oxidative Stress; Oxygen; Random Allocation; Regional Blood Flow; Swine; Tyrosine | 2008 |
Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine.
Topics: Animals; Antigens; Apoptosis; Biomarkers; Cell Adhesion Molecules; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Gentamicins; Immunoenzyme Techniques; Immunohistochemistry; Kidney; Kidney Tubules, Proximal; Male; Mercuric Chloride; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Potassium Dichromate; Rats; Rats, Sprague-Dawley; Tyrosine; Up-Regulation; Xenobiotics | 2008 |
Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model.
Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Crk-Associated Substrate Protein; Dasatinib; Disease Models, Animal; Drug Delivery Systems; Focal Adhesion Kinase 1; Humans; Lymphatic Metastasis; Male; Mice; Mice, Nude; Prostatic Neoplasms; Pyrimidines; src-Family Kinases; Thiazoles; Tumor Burden; Tumor Cells, Cultured; Tyrosine; Xenograft Model Antitumor Assays | 2008 |
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Antioxidants; Aorta; Biopterins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Glutathione; HIV Infections; HIV-1; Human Immunodeficiency Virus Proteins; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Proviruses; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Superoxides; Thiazolidines; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2008 |
Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress.
Topics: Acetylcholine; Anemia, Sickle Cell; Animals; Arginine; Citrulline; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Globins; Heme Oxygenase-1; Hemodynamics; Hemoglobins; Hemolysis; Humans; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Tyrosine; Vasodilator Agents | 2008 |
Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis.
Topics: Acetylcysteine; Animals; Antioxidants; Bile Ducts; Disease Models, Animal; Free Radical Scavengers; Ligation; Liver Circulation; Liver Cirrhosis, Biliary; Liver Function Tests; Male; Microcirculation; Oxidants; Peptide Fragments; Procollagen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Thromboxane-A Synthase; Tyrosine; Vascular Resistance | 2008 |
Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist combination on nitric oxide bioavailability and atherosclerotic change in Watanabe heritable hyperlipidemic rabbits.
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Atherosclerosis; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Heart Rate; Hyperlipidemias; Losartan; Male; Nitric Oxide; Peroxynitrous Acid; Rabbits; Tyrosine; Vasodilator Agents | 2008 |
The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology.
Topics: Anemia, Sickle Cell; Animals; Arginine; Disease Models, Animal; Hemodynamics; Hemoglobins; Hemolysis; Humans; Microcirculation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Tyrosine; Vasodilator Agents | 2008 |
Tyrosine aminotransferase deficiency in mink (Mustela vision): a model for human tyrosinemia II.
Topics: Amino Acid Metabolism, Inborn Errors; Animal Diseases; Animals; Aspartate Aminotransferases; Disease Models, Animal; Humans; Immunodiffusion; Mink; Mitochondria, Liver; Rats; Species Specificity; Tyrosine; Tyrosine Transaminase | 1981 |
Regulation of hepatic tyrosine aminotransferase in genetically obese rats.
Topics: Adrenalectomy; Aging; Amino Acids; Animals; Corticosterone; Diet; Disease Models, Animal; Enzyme Activation; Insulin; Liver; Obesity; Rats; Tryptophan; Tyrosine; Tyrosine Transaminase | 1983 |
Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Homovanillic Acid; Male; Parkinson Disease; Rats; Substantia Nigra; Synaptic Transmission; Tyrosine | 1980 |
Induction of an experimental phenylketonuria-like condition in infant rats during the first 2 weeks after birth.
Topics: Animals; Animals, Newborn; Diet; Disease Models, Animal; Female; Fenclonine; Humans; Male; Methotrexate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine | 1981 |
Tyrosine's vasoactive effect in the dog shock model depends on the animal's starting blood pressure.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Hypotension; Tyrosine | 1983 |
In vivo safety of hollow fiber enzyme-reactors with immobilized phenylalanine ammonia-lyase in a large animal model for phenylketonuria.
Topics: Ammonia-Lyases; Animals; Blood Cells; Blood Urea Nitrogen; Disease Models, Animal; Dogs; Enzymes, Immobilized; Female; Humans; Macaca; Male; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Time Factors; Tyrosine | 1983 |
Tyrosine increases blood pressure in hypotensive rats.
Topics: Adrenalectomy; Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Hypotension; Male; Rats; Tyrosine | 1981 |
Tyrosine administration decreases vulnerability to ventricular fibrillation in the normal canine heart.
Topics: Animals; Blood-Brain Barrier; Catecholamines; Disease Models, Animal; Dogs; Tyrosine; Valine; Ventricular Fibrillation | 1981 |
Hyperoxic injury of immature guinea pig lung is mediated via hydroxyl radicals.
Topics: Animals; Animals, Newborn; Body Weight; Disease Models, Animal; Female; Guinea Pigs; Hydroxyl Radical; Hyperoxia; Lung; Lung Diseases; Lysine; Male; Oxidative Stress; Pregnancy; Survival Rate; Tyrosine | 1995 |
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Immunoglobulin G; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Muscles; Neutralization Tests; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor, Insulin; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; Body Weight; Cerebral Cortex; Chronic Disease; Dialysis; Disease Models, Animal; Dopamine; Extracellular Space; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Norepinephrine; Phenylalanine; Rats; Rats, Wistar; Serotonin; Tryptophan; Tyrosine | 1995 |
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.
Topics: alpha-Fetoproteins; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Female; Heptanoates; Humans; Hydrolases; Liver; Liver Diseases; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Nitrobenzoates; Pancreas; RNA, Messenger; Tyrosine | 1995 |
Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Disease Models, Animal; Enzyme Induction; Female; Gene Expression; Guanidines; Guinea Pigs; Ileitis; Immunohistochemistry; Male; Molecular Sequence Data; Nitric Oxide Synthase; Nitrites; Tyrosine | 1995 |
Isolation and culture of retinal microglia.
Topics: Animals; Cell Division; Cell Separation; Cells, Cultured; Disease Models, Animal; Lectins; Macrophage-1 Antigen; Microscopy, Fluorescence; Neuroglia; Phagocytosis; Phosphotyrosine; Rats; Rats, Mutant Strains; Retina; Retinal Degeneration; Tyrosine; Vimentin | 1993 |
Experimental carotid thrombosis in the guinea pig.
Topics: Acetates; Animals; Aspirin; Biomechanical Phenomena; Blood Flow Velocity; Blood Pressure; Carotid Artery Thrombosis; Disease Models, Animal; Guinea Pigs; Heparin; Hirudin Therapy; Male; Partial Thromboplastin Time; Platelet Aggregation; Platelet Count; Tyrosine | 1994 |
Rescue of mice homozygous for lethal albino deletions: implications for an animal model for the human liver disease tyrosinemia type 1.
Topics: Albinism; Animals; Disease Models, Animal; Gene Deletion; Gene Expression; Homozygote; Humans; Hydrolases; Hypoglycemia; Liver; Liver Diseases; Mice; Mice, Transgenic; Phenotype; Tyrosine | 1993 |
Effect of platelet on protein degradation in rat skeletal muscle.
Topics: Animals; Disease Models, Animal; Disseminated Intravascular Coagulation; Humans; In Vitro Techniques; Leucine; Male; Muscle Proteins; Muscles; Platelet Activation; Rats; Rats, Sprague-Dawley; Thrombin; Tyrosine | 1993 |
A comparative study on protein incorporation of L-[methyl-3H]methionine, L-[1-14C]leucine and L-2-[18F]fluorotyrosine in tumor bearing mice.
Topics: Animals; Brain; Carbon Radioisotopes; Disease Models, Animal; Fluorine Radioisotopes; Hydrogen-Ion Concentration; Leucine; Lipid Metabolism; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Inbred C3H; Neoplasm Proteins; Nerve Tissue Proteins; Nucleic Acids; Solubility; Tissue Distribution; Tomography, Emission-Computed; Tritium; Tyrosine | 1993 |
Experimental research on a new treatment for maternal phenylketonuria(PKU).
Topics: Animals; Biopterins; Brain; Disease Models, Animal; Female; Fetus; Guinea Pigs; Infusions, Intravenous; Liver; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Tyrosine | 1993 |
Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Cell Count; Cell Transplantation; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Genetic Therapy; Humans; Hydrolases; Immunoenzyme Techniques; Liver; Liver Function Tests; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Nitrobenzoates; Retroviridae; Tyrosine | 1996 |
Tyrosine uptake and regional brain monoamine metabolites in a rat model resembling congenital hyperammonemia.
Topics: Amino Acids; Ammonia; Animals; Body Weight; Brain; Disease Models, Animal; Dopamine; Eating; Homovanillic Acid; Male; Norepinephrine; Rats; Rats, Wistar; Tyrosine; Urease; Vanilmandelic Acid | 1996 |
Behavioral and neurochemical alterations caused by diet restriction--the effect of tyrosine administration in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anorexia Nervosa; Brain; Cognition; Diet, Reducing; Disease Models, Animal; Dopamine; Female; Hippocampus; Maze Learning; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Norepinephrine; Nutritional Requirements; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tyrosine; Weight Loss | 1996 |
NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Male; Nerve Growth Factors; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
In vivo correction with recombinant adenovirus of 4-hydroxyphenylpyruvic acid dioxygenase deficiencies in strain III mice.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Adenoviridae; Animals; Blotting, Northern; Cells, Cultured; Disease Models, Animal; DNA Primers; DNA, Recombinant; Gene Expression Regulation, Viral; Genetic Therapy; Genetic Vectors; Humans; Liver; Mice; Mice, Inbred Strains; RNA, Messenger; Tyrosine | 1997 |
Formation of nitrosyl hemoglobin and nitrotyrosine during murine leishmaniasis.
Topics: Animals; Disease Models, Animal; Female; Hemoglobins; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide; Photobiology; Tyrosine | 1996 |
Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I.
Topics: Adenoviridae; Animals; Blotting, Southern; Carcinoma, Hepatocellular; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Humans; Hydrolases; Liver Neoplasms; Mice; Tyrosine | 1997 |
Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques.
Topics: Acquired Immunodeficiency Syndrome; Animals; CD4 Antigens; COS Cells; Disease Models, Animal; Down-Regulation; Genes, nef; Humans; Jurkat Cells; Macaca mulatta; Phosphorylation; Protein Serine-Threonine Kinases; Simian Immunodeficiency Virus; src-Family Kinases; Tyrosine; Virus Replication | 1997 |
Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Kidney; Neprilysin; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tyrosine; Urination; Weight Gain | 1997 |
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
Topics: Animals; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Immunoenzyme Techniques; Inflammation; Male; Melatonin; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pleurisy; Rats; Rats, Sprague-Dawley; Tyrosine | 1997 |
Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Antineoplastic Agents; Creatine; Creatinine; Disease Models, Animal; Energy Metabolism; Free Radicals; Huntington Disease; Lactates; Male; Malonates; Neostriatum; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Sprague-Dawley; Tyrosine | 1998 |
Ex vivo hepatic gene therapy of a mouse model of Hereditary Tyrosinemia Type I.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Base Sequence; Cell Survival; Cell Transplantation; Cells, Cultured; Cyclohexanones; Disease Models, Animal; DNA, Complementary; Enzyme Inhibitors; Female; Genetic Diseases, Inborn; Genetic Therapy; Humans; Hydrolases; Liver; Male; Mice; Molecular Sequence Data; Nitrobenzoates; Tyrosine | 1998 |
Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.
Topics: Animals; Creatine Kinase; Cytokines; Dexamethasone; Disease Models, Animal; Dogs; Guanidines; Heart; Hemodynamics; Histocytochemistry; Inflammation; Interleukin-1; Isoenzymes; Leukocyte Count; Microspheres; Myocardium; Nitrates; Nitric Oxide; Peroxidase; Tyrosine; Ventricular Dysfunction, Left | 1998 |
Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors.
Topics: Acetoacetates; Amino Acid Metabolism, Inborn Errors; Animals; Apoptosis; Cell-Free System; Cysteine Proteinase Inhibitors; Cytochrome c Group; Disease Models, Animal; Liver; Mice; Mice, Knockout; Mitochondria, Liver; Tyrosine | 1998 |
A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Macaca mulatta; Parkinson Disease, Secondary; Tomography, Emission-Computed; Tyrosine | 1998 |
Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide.
Topics: Aged; Analysis of Variance; Animals; Antioxidants; Aqueous Humor; Ascorbic Acid; Cataract; Chromatography, High Pressure Liquid; Cysteine; Disease Models, Animal; Female; Glutathione; Humans; Hydrogen Peroxide; Mammals; Oxidants; Rabbits; Rats; Rats, Sprague-Dawley; Tryptophan; Tyrosine; Ultraviolet Rays; Uric Acid | 1998 |
Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model.
Topics: Animals; Anti-Bacterial Agents; Bleomycin; Disease Models, Animal; Hydroxyproline; Immunohistochemistry; Lung; Lung Diseases, Interstitial; Macrophages, Alveolar; Mice; Nitric Oxide; Superoxides; Tyrosine | 1998 |
Aromatic hydroxylation in animal models of diabetes mellitus.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Fructosamine; Hydroxylation; Kidney; Lysine; Malondialdehyde; Mice; Rats; Rats, Inbred BB; Rats, Sprague-Dawley; Streptozocin; Tyrosine | 1998 |
Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria?
Topics: Animals; Brain; Dihydroxyphenylalanine; Disease Models, Animal; Female; Malaria, Cerebral; Membrane Glycoproteins; Mice; Mice, Inbred CBA; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Plasmodium berghei; Reactive Oxygen Species; Tyrosine; Uric Acid | 1999 |
Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury.
Topics: Animals; Blood Vessels; Bronchi; Bronchoalveolar Lavage Fluid; Coloring Agents; Disease Models, Animal; Endotoxins; Epithelium; Escherichia coli; Female; Follow-Up Studies; Isoenzymes; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Macrophages, Alveolar; Male; Mice; Mice, Knockout; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Size; Pulmonary Alveoli; Respiratory Distress Syndrome; Tyrosine; Vasodilator Agents | 1998 |
Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Division; Cetuximab; Disease Models, Animal; ErbB Receptors; Humans; Kidney Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Recombinant Fusion Proteins; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrosine | 1998 |
IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis.
Topics: Aluminum Hydroxide; Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD40 Antigens; CD40 Ligand; Cells, Cultured; Coculture Techniques; Dermatitis, Atopic; Disease Models, Animal; Dose-Response Relationship, Immunologic; Humans; Hypergammaglobulinemia; Immunization; Immunoglobulin E; Immunoglobulin G; Interleukin-4; Janus Kinase 3; Ligands; Lymphocyte Activation; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Ovalbumin; Phosphorylation; Protein-Tyrosine Kinases; Thy-1 Antigens; Tyrosine | 1999 |
Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.
Topics: Animals; Colitis; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Malondialdehyde; Mice; Neutrophils; Oxidative Stress; Permeability; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid; Tyrosine; Up-Regulation | 1999 |
Role of nitric oxide in lipopolysaccharide-induced hepatic injury in D-galactosamine-sensitized mice as an experimental endotoxic shock model.
Topics: Animals; Disease Models, Animal; Female; Galactosamine; Heat-Shock Proteins; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rabbits; RNA, Messenger; Shock, Septic; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Escherichia coli; Female; Immunohistochemistry; Inflammation; Interferon-gamma; Interleukin-10; Intestinal Mucosa; Intestines; Lipopolysaccharides; Macrophages; Mice; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Shock, Septic; Spermine; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat.
Topics: Acetylcysteine; Animals; Cell Membrane Permeability; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Macrophages, Peritoneal; Male; NAD; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sepsis; Shock; Tyrosine; Zymosan | 1999 |
Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Division; Disease Models, Animal; Drug Synergism; Emodin; Enzyme Inhibitors; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1999 |
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Creatine; Disease Models, Animal; Glycine; Humans; Mice; Mice, Transgenic; Motor Activity; Muscle, Skeletal; Neurons; Neuroprotective Agents; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine; Tyrosine 3-Monooxygenase | 1999 |
High levels of peroxynitrite are generated in the lungs of irradiated mice given cyclophosphamide and allogeneic T cells. A potential mechanism of injury after marrow transplantation.
Topics: Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Disease Models, Animal; Female; L-Lactate Dehydrogenase; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; T-Lymphocytes; Time Factors; Tyrosine | 1999 |
The protective role of endogenous glutathione in carrageenan-induced pleurisy in the rat.
Topics: Animals; Carrageenan; Cells, Cultured; Disease Models, Animal; Free Radical Scavengers; Glutathione; Macrophages; Nitrates; Nitric Oxide; Oxidants; Pleurisy; Protective Agents; Rats; Tyrosine | 1999 |
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
Topics: Animals; Cartilage, Articular; Culture Techniques; Cyclooxygenase 2; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Immunohistochemistry; Interleukin-1; Isoenzymes; Lysine; Metalloendopeptidases; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Sensitivity and Specificity; Statistics, Nonparametric; Synovial Membrane; Tyrosine | 1999 |
Regulation of aquaporin-1 and nitric oxide synthase isoforms in a rat model of acute peritonitis.
Topics: Acute Disease; Analysis of Variance; Animals; Aquaporin 1; Aquaporins; Capillary Permeability; Disease Models, Animal; Endothelial Growth Factors; Immunoassay; Immunohistochemistry; Isoenzymes; Lymphokines; Male; Nitric Oxide Synthase; Peritoneal Dialysis; Peritoneum; Peritonitis; Protein Isoforms; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I.
Topics: Acetoacetates; Alanine Transaminase; Animals; Cloning, Molecular; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Gene Conversion; Gene Deletion; Genotype; Heterozygote; Liver; Loss of Heterozygosity; Mice; Mice, Knockout; Models, Genetic; Mutagenesis; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction; Suppression, Genetic; Tyrosine; Tyrosinemias | 1999 |
Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan.
Topics: Animals; Antioxidants; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Kidney; Lipid Peroxidation; Liver; Lung; Male; Malondialdehyde; Melatonin; Nitrates; Rats; Rats, Sprague-Dawley; Shock; Tyrosine; Zymosan | 1999 |
Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Immunohistochemistry; L-Lactate Dehydrogenase; Lung; Male; Malondialdehyde; Metalloporphyrins; NAD; Nitrates; Peroxidase; Rats; Rats, Sprague-Dawley; Shock; Superoxide Dismutase; Tyrosine; Zymosan | 1999 |
Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Brain; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Mutation; Neuroglia; Neurons; Spinal Cord; Superoxide Dismutase; Tyrosine | 2000 |
Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catechols; Convulsants; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Female; Free Radicals; Glutathione; Glutathione Peroxidase; Heterozygote; Homovanillic Acid; Homozygote; Huntington Disease; Male; Malonates; Mice; Mice, Inbred Strains; Mice, Knockout; MPTP Poisoning; Nitro Compounds; Oxidative Stress; Parkinson Disease, Secondary; Propionates; Tyrosine | 2000 |
Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Body Weight; Cyclic N-Oxides; Disease Models, Animal; Enzyme Activation; Free Radical Scavengers; Joints; Kinetics; Male; Poly(ADP-ribose) Polymerases; Radiography; Rats; Rats, Inbred Lew; Severity of Illness Index; Spin Labels; Time Factors; Tyrosine | 2000 |
Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression.
Topics: 3T3 Cells; Animals; Disease Models, Animal; Disease Progression; DNA Replication; Hydrolysis; Mice; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rabbits; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; src-Family Kinases; Tyrosine; Ubiquitin-Protein Ligases; Vitreoretinopathy, Proliferative | 2000 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Free Radical Scavengers; Mice; Multiple Sclerosis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Spinal Cord; Tyrosine; Uric Acid | 2000 |
Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase.
Topics: Adenoviridae; Animals; Calcium Channel Blockers; Cardiomegaly; Cell Adhesion; Cells, Cultured; Cytoskeletal Proteins; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Heart; Myocardium; Myosin Heavy Chains; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 2000 |
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Blood Pressure; Catalysis; Celiac Artery; Disease Models, Animal; Endothelium, Vascular; Ferric Compounds; Ileum; Intercellular Adhesion Molecule-1; Leukocyte Count; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhodamines; Splanchnic Circulation; Tyrosine | 2000 |
Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs.
Topics: Animals; Benzamides; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Escherichia coli Infections; Female; Hemodynamics; Immunohistochemistry; Lipopolysaccharides; Male; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proteins; Pulmonary Circulation; Respiratory Distress Syndrome; Respiratory Mechanics; Shock, Septic; Swine; Tyrosine | 2000 |
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat.
Topics: Acute Kidney Injury; Animals; Cell Membrane Permeability; Cell Separation; Cells, Cultured; Chelating Agents; Cyclic N-Oxides; Deferoxamine; Disease Models, Animal; Free Radical Scavengers; Hydrogen Peroxide; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Malondialdehyde; Necrosis; Oxidants; Oxidative Stress; Peroxidase; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reperfusion Injury; Spin Labels; Tyrosine | 2000 |
Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia.
Topics: Acetylcholine; Animals; Aorta; Arteriosclerosis; Cystathionine beta-Synthase; Dinoprost; Disease Models, Animal; Endothelium, Vascular; F2-Isoprostanes; Heterozygote; Humans; Hyperhomocysteinemia; In Vitro Techniques; Lipid Peroxides; Mice; Mice, Mutant Strains; Nitroprusside; Reactive Oxygen Species; Risk Factors; Thrombosis; Tyrosine; Vasodilation | 2000 |
Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis.
Topics: Animals; Benzamides; Chronic Disease; Colitis; Disease Models, Animal; Energy Metabolism; Enzyme Inhibitors; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Intestinal Absorption; Intestinal Mucosa; Mice; Mice, Inbred Strains; Mice, Knockout; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Evidence for oxidative stress in experimental prion disease.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Glial Fibrillary Acidic Protein; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Membrane Proteins; Mice; Oxidative Stress; Prion Diseases; Tyrosine | 2000 |
Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypertension; Immunoassay; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Thiocarbamates; Tyrosine; Vasodilation | 2000 |
Inhibition of growth hormone action in models of inflammation.
Topics: Acute-Phase Reaction; Animals; Cell Nucleus; Cells, Cultured; Choline O-Acetyltransferase; Culture Media, Conditioned; Disease Models, Animal; DNA-Binding Proteins; Gene Expression; Genes, Reporter; Growth Hormone; Hepatocytes; Hypophysectomy; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Milk Proteins; Monocytes; Nuclear Proteins; Phosphorylation; Protein Binding; Rats; Rats, Sprague-Dawley; Response Elements; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Prevention of dopaminergic neurotoxicity by targeting nitric oxide and peroxynitrite: implications for the prevention of methamphetamine-induced neurotoxic damage.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Cyclic N-Oxides; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Electrochemistry; Free Radical Scavengers; Homovanillic Acid; Imidazoles; Indazoles; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Models, Biological; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Peroxynitrous Acid; Tyrosine | 2000 |
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; beta-Synuclein; Cell Line; Corpus Striatum; Disease Models, Animal; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Oxidation-Reduction; Parkinsonian Disorders; Peroxynitrous Acid; Precipitin Tests; Protein Processing, Post-Translational; Synaptophysin; Synucleins; Transfection; Tyrosine | 2001 |
Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty.
Topics: Acetates; Angioplasty, Balloon, Coronary; Animals; Cell Adhesion; Disease Models, Animal; Immunohistochemistry; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Vitronectin; Swine; Thrombosis; Tunica Intima; Tyrosine | 2001 |
Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities.
Topics: Animals; Cytoskeleton; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; SAP90-PSD95 Associated Proteins; Seizures; Subcellular Fractions; Synaptic Membranes; Tyrosine | 2001 |
Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Ischemic Attack, Transient; Male; Middle Cerebral Artery; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Reference Values; Superoxides; Tamoxifen; Tyrosine | 2001 |
Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat.
Topics: Acetylcysteine; Animals; Blotting, Western; Carrageenan; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Erythrocytes; Free Radical Scavengers; I-kappa B Proteins; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lung; Macrophages; Male; Malondialdehyde; Neutrophils; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide; P-Selectin; Peroxidase; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Free 3-nitrotyrosine causes striatal neurodegeneration in vivo.
Topics: Animals; Cell Count; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Immunohistochemistry; Mice; Motor Activity; Neurodegenerative Diseases; Neurons; Oxidopamine; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2001 |
Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lysine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Superoxides; Trinitrobenzenesulfonic Acid; Tyrosine | 2001 |
Nitric oxide and Coxsackievirus B3 myocarditis: differential expression of inducible nitric oxide synthase in mouse heart after infection with virulent or attenuated virus.
Topics: Animals; Disease Models, Animal; Enterovirus; Guanosine Monophosphate; Heart; Immunohistochemistry; Male; Mice; Myocarditis; Myocardium; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nucleic Acid Hybridization; RNA, Viral; Tyrosine | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation.
Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Enzyme Inhibitors; Glucose; Hypoxia-Ischemia, Brain; Immunohistochemistry; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Purkinje Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Tyrosine | 2001 |
Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Apoptosis; Blotting, Western; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Caspase 3; Caspase 9; Caspases; Cytochrome c Group; Disease Models, Animal; Dogs; Enzyme Activation; Hemodynamics; Immunohistochemistry; In Situ Nick-End Labeling; Myocardium; Oxidative Stress; Protein Biosynthesis; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Tumor Suppressor Protein p53; Tyrosine; Ventricular Dysfunction | 2001 |
Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
Topics: Administration, Inhalation; Animals; Blotting, Western; Cells, Cultured; Dioxoles; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Humans; Hypertension, Pulmonary; Lung; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pulmonary Artery; Receptor, Endothelin A; Secondary Prevention; Sheep; Superoxides; Tyrosine | 2001 |
Enhanced nitric oxide inactivation in aortic coarctation-induced hypertension.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Coarctation; Baroreflex; Blotting, Western; Brain; Disease Models, Animal; Hypertension; Male; Myocardium; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Cyclophosphamide decreases nitrotyrosine formation and inhibits nitric oxide production by alveolar macrophages in mycoplasmosis.
Topics: Animals; Cells, Cultured; Cyclophosphamide; Disease Models, Animal; Immunosuppressive Agents; Leukocyte Count; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycoplasma; Mycoplasma Infections; Neutrophils; Nitric Oxide; Tyrosine | 2001 |
Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice.
Topics: Acetophenones; Amidines; Animals; Antioxidants; Benzylamines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Eosinophils; Hypersensitivity; Immunoglobulin E; Immunohistochemistry; Interferon-gamma; Interleukin-4; Interleukin-5; Lung; Male; Mice; Mice, Inbred BALB C; Neutrophils; Nitric Oxide Synthase; Ovalbumin; Specific Pathogen-Free Organisms; Tyrosine | 2001 |
Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Cyclic N-Oxides; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Hypertension, Renovascular; Losartan; Male; Nephrectomy; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Artery; Renin; Spin Labels; Superoxides; Systole; Time Factors; Tyrosine | 2001 |
Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs.
Topics: Animals; Blood Gas Analysis; Blotting, Western; Disease Models, Animal; Hemodynamics; Lipopolysaccharides; Liver; Lung; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Sepsis; Swine; Tyrosine | 2001 |
Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.
Topics: Animals; Bromine; Chlorine; Disease Models, Animal; HL-60 Cells; Humans; Hypochlorous Acid; Ions; Klebsiella Infections; Klebsiella pneumoniae; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Oxidants; Peroxidase; Sepsis; Tyrosine | 2001 |
Expression of inducible nitric oxide synthase and nitrotyrosine during the evolution of experimental pulmonary tuberculosis.
Topics: Animals; Cell Count; Disease Models, Animal; Immunoenzyme Techniques; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; Microscopy, Immunoelectron; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tuberculosis, Pulmonary; Tyrosine | 2001 |
Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia.
Topics: Animals; Blood Vessels; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Hyperglycemia; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Nerve Degeneration; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2001 |
Reduced activity and protein expression of NOS in R6/2 HD transgenic mice: effects of L-NAME on symptom progression.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Disease Models, Animal; Enzyme Inhibitors; Female; Huntington Disease; Immunohistochemistry; Male; Mice; Mice, Transgenic; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Tyrosine | 2001 |
Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.
Topics: Animals; Arginine; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Drug Interactions; Endotoxins; Ethanol; Humans; Inflammation; Isoenzymes; Lipid Peroxidation; Liver; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Male; Membrane Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Effect of maternal blood phenylalanine level on mouse maternal phenylketonuria offspring.
Topics: Abortion, Spontaneous; Animals; Disease Models, Animal; Embryonic and Fetal Development; Female; Fetal Diseases; Humans; Male; Mice; Phenylalanine; Phenylketonuria, Maternal; Pregnancy; Tyrosine | 2001 |
Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Experimental; Arthritis, Rheumatoid; Arthrography; Collagen; Collagen Type XI; Disease Models, Animal; Interleukin-1; Joints; Male; Manganese; Molecular Weight; Organometallic Compounds; Proteins; Rats; Rats, Inbred Lew; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Weight Gain | 2001 |
Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral cortex.
Topics: Animals; Blotting, Western; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Glucose; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2002 |
Long-term therapy with NTBC and tyrosine-restricted diet in a murine model of hereditary tyrosinemia type I.
Topics: Animals; Cyclohexanones; Diet; Disease Models, Animal; Enzyme Inhibitors; Hydrolases; Mice; Mice, Knockout; Nitrobenzoates; Phenylalanine; Tyrosine; Tyrosinemias | 2002 |
Ebselen suppresses late airway responses and airway inflammation in guinea pigs.
Topics: Airway Resistance; Animals; Antineoplastic Agents, Alkylating; Antioxidants; Area Under Curve; Asthma; Azoles; Bronchitis; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Female; Guinea Pigs; Hydrogen Peroxide; Immunoenzyme Techniques; Isoindoles; Lung; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organoselenium Compounds; Ovalbumin; Peptide Fragments; Rabbits; Reactive Nitrogen Species; Reactive Oxygen Species; Respiratory Function Tests; Respiratory Hypersensitivity; Superoxides; Tyrosine | 2002 |
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.
Topics: Animals; Biopterins; Brain; Calcium; Calmodulin; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Flavin-Adenine Dinucleotide; Male; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; Rats; Rats, Inbred Lew; RNA, Messenger; Subcellular Fractions; Tyrosine | 2002 |
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Bacterial Agents; Astrocytes; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Interleukin-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Minocycline; NADPH Oxidases; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Parkinsonian Disorders; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase; Up-Regulation | 2002 |
N-methyl-D-aspartate receptors: transient loss of NR1/NR2A/NR2B subunits after traumatic brain injury in a rodent model.
Topics: Animals; Brain Injuries; Disease Models, Animal; Gene Expression; Hippocampus; Male; Memory; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tyrosine | 2002 |
Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury.
Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Heart; Heart Rate; Incidence; Lipid Peroxidation; Myocardial Reperfusion Injury; Myocardium; Protective Agents; Rats; Reperfusion Injury; Tachycardia; Tyrosine; Ventricular Fibrillation | 2002 |
Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Apoptosis; Disease Models, Animal; DNA; DNA-Binding Proteins; Endotoxins; Enzyme Activation; Hypertension; I-kappa B Proteins; Lung; Male; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sesquiterpenes; Shock, Septic; Tyrosine | 2002 |
Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cytokines; Disease Models, Animal; Erythrocytes; Intercellular Adhesion Molecule-1; Male; P-Selectin; Pleurisy; Poly(ADP-ribose) Polymerases; Pyrazoles; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sulfonamides; Tyrosine | 2002 |
Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Encephalitis; Hypothermia, Induced; Infarction, Middle Cerebral Artery; Lipopolysaccharides; Male; Microglia; Monocytes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Stroke; Tyrosine | 2002 |
Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy.
Topics: Aging; Amidines; Animals; Animals, Newborn; Apoptosis; Benzylamines; Cell Count; Crosses, Genetic; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Proteins; Retina; Retinal Diseases; Retinal Vein Occlusion; Tyrosine | 2002 |
Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Endotoxins; Enzyme Inhibitors; Guanidines; Heart; In Vitro Techniques; Male; Myocytes, Cardiac; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Perfusion; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
Increase in oxidative stress in kidneys of diabetic Akita mice.
Topics: Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Kidney; Lysine; Mice; Mice, Mutant Strains; Oxidation-Reduction; Oxidative Stress; Tyrosine | 2002 |
CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, CD19; Antigens, Differentiation; B-Lymphocytes; Blotting, Western; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Fibrosis; Flow Cytometry; Humans; Hydroxyproline; Immunoglobulin M; Interleukin-6; Membrane Glycoproteins; Mice; NAD+ Nucleosidase; Phosphorylation; Precipitin Tests; Scleroderma, Systemic; Signal Transduction; Skin; Time Factors; Tyrosine; Up-Regulation | 2002 |
Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase.
Topics: Animals; Asbestos, Crocidolite; Asbestosis; Body Weight; Bronchoalveolar Lavage Fluid; Cell Count; Cricetinae; Disease Models, Animal; Inhalation Exposure; Intubation, Intratracheal; Lung; Mesocricetus; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Peroxidase; Rats; RNA, Messenger; Species Specificity; Thiobarbituric Acid Reactive Substances; Tyrosine | 2002 |
Nitric oxide in the development of obliterative bronchiolitis in a heterotopic pig model.
Topics: Animals; Bronchi; Bronchiolitis Obliterans; Cell Division; Disease Models, Animal; Fibroblasts; Lung Transplantation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Respiratory Mucosa; Superoxide Dismutase; Swine; Tyrosine | 2002 |
Biochemical basis of an animal model of depressive illness--a preliminary report--.
Topics: Adjustment Disorders; Animals; Brain Chemistry; Conditioning, Classical; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Liver; Male; Motor Activity; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase; Tyrosine; Tyrosine Transaminase | 1976 |
Molecular biology and molecular pathology of a newly described molecular disease--tyrosinemia II (the Richner-Hanhart syndrome).
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Child; Crystallization; Disease Models, Animal; Eye Diseases; Female; Hemolysis; Heterozygote; Humans; In Vitro Techniques; Infant; Infant, Newborn; Intellectual Disability; Liver; Lysosomes; Male; Rats; Skin Diseases; Syndrome; Tyrosine; Tyrosine Transaminase | 1978 |
In vivo inhibition of rat liver phenylalanine hydroxylase by p-chlorophenylalanine and Esculin. Experimental model of phenylketonuria.
Topics: Animals; Disease Models, Animal; Esculin; Female; Fenclonine; Flavonoids; Humans; Liver; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine | 1975 |
The regulation of phenylalanine hydroxylase in rat tissues in vivo. The maintenance of high plasma phenylalanine concentrations in suckling rats: a model for phenylketonuria.
Topics: Animals; Brain; Disease Models, Animal; Fenclonine; Humans; Kidney; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine | 1976 |
A new experimental model of hyperphenylalaninemia in rat. Effect of p-chlorophenylalanine and cotrimoxazole.
Topics: Animals; Disease Models, Animal; Drug Combinations; Fenclonine; Humans; Kidney; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Sulfamethoxazole; Trimethoprim; Tyrosine | 1977 |
Influences of exogenous intake and nitrogen balance on plasma and brain aromatic amino acid concentrations.
Topics: Amino Acids; Animals; Disease Models, Animal; Female; Liver Diseases; Nitrogen; Octopamine; Parenteral Nutrition; Phenylalanine; Portacaval Shunt, Surgical; Rats; Tryptophan; Tyrosine | 1978 |
[Comparative effects of different inhibitors of phenylalanine hydroxylase and dihydropteridine reductase. In vivo and in vitro study in rats].
Topics: Animals; Dihydropteridine Reductase; Disease Models, Animal; Humans; Liver; NADH, NADPH Oxidoreductases; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine | 1978 |
Experimental phenylketonuria: replacement of carboxyl terminal tyrosine by phenylalanine in infant rat brain tubulin.
Topics: Amino Acid Sequence; Animals; Brain; Cytoplasm; Disease Models, Animal; Humans; Microtubules; Phenylalanine; Phenylketonurias; Protein Binding; Rats; Tubulin; Tyrosine | 1979 |
Dopaminergic agonists in animal models of parkinsonism.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Cats; Disease Models, Animal; Haplorhini; Levodopa; Parkinson Disease, Secondary; Piribedil; Rats; Reserpine; Tyrosine | 1975 |
Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat.
Topics: Animals; Brain; Disease Models, Animal; Fatty Acids; Histidine; Hydroxyindoleacetic Acid; Hypothalamus; Isoleucine; Leucine; Liver Cirrhosis; Phenylalanine; Portacaval Shunt, Surgical; Rats; Serotonin; Tryptophan; Tyrosine; Valine | 1976 |
Actions of dopaminergic agonists on motor function.
Topics: Amantadine; Animals; Apomorphine; Behavior; Dextroamphetamine; Disease Models, Animal; Dopamine Antagonists; Humans; Hyperkinesis; Levodopa; Methylphenidate; Motor Activity; Movement Disorders; Phenethylamines; Piribedil; Rats; Stereotyped Behavior; Tyrosine | 1975 |
Urolithiasis induced with DL-3,a-dimethyltyrosine methylester HCl. I. A scanning electron microscopic investigation.
Topics: Animals; Disease Models, Animal; Kidney Cortex; Kidney Glomerulus; Male; Microscopy, Electron, Scanning; Rats; Tyrosine; Urinary Bladder; Urinary Calculi | 1975 |
Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats.
Topics: Adenosine Triphosphate; Age Factors; Animals; Bacterial Infections; Cecum; Disease Models, Animal; Ligation; Male; Methylhistidines; Muscle Proteins; Muscles; Phosphocreatine; Rats; Rats, Sprague-Dawley; Tyrosine | 1992 |
Metabolic studies in a mouse model of hepatorenal tyrosinemia: absence of perinatal abnormalities.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Chromosome Deletion; Disease Models, Animal; Heptanoates; Homozygote; Hydrolases; Kidney; Liver; Mice; Mice, Mutant Strains; Tyrosine | 1992 |
Putative genetic deficiency of 4-hydroxyphenylpyruvic acid dioxygenase in mice: a murine model for hereditary tyrosinaemia type III.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Liver; Mice; Mice, Inbred Strains; Tyrosine | 1990 |
Hyperphenylalaninemia in the hph-1 mouse mutant.
Topics: Aminohydrolases; Animals; Biopterins; Disease Models, Animal; GTP Cyclohydrolase; Half-Life; Male; Metabolic Clearance Rate; Mice; Mice, Mutant Strains; Phenylalanine; Tyrosine | 1988 |
Outcome of pregnancy in the rat with mild hyperphenylalaninaemia and hypertyrosinaemia: implications for the management of "human maternal PKU".
Topics: Animals; Brain Diseases; Discrimination, Psychological; Disease Models, Animal; Female; Motor Activity; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Space Perception; Tyrosine | 1985 |
Modification of 1-tyrosine-induced keratopathy by adrenal corticosteroids.
Topics: Animals; Betamethasone; Corneal Opacity; Dexamethasone; Dietary Proteins; Disease Models, Animal; Female; Glucocorticoids; Injections, Intramuscular; Keratitis; Liver; Ophthalmic Solutions; Phenobarbital; Prednisone; Rats; Tyrosine; Tyrosine Transaminase | 1974 |
On the mechanism of fever caused by the mucopeptide of group A streptococcus.
Topics: Animals; Bacterial Proteins; Brain; Disease Models, Animal; Fenclonine; Fever; Injections, Intravenous; Injections, Spinal; Mucoproteins; Norepinephrine; Phenylalanine; Premedication; Rabbits; Reserpine; Serotonin; Streptococcus; Streptococcus pyogenes; Tyrosine | 1972 |
Some biochemical and behavioural correlates of a possible animal model of human hyperkinetic syndromes.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Catecholamines; Cats; Caudate Nucleus; Chlorpromazine; Cholinesterase Inhibitors; Chromatography, Thin Layer; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Electric Stimulation; Ganglionic Blockers; Movement Disorders; Phenylacetates; Picrotoxin; Rats; Tranquilizing Agents; Tritium; Tubocurarine; Tyrosine | 1972 |
Histopathology of keratopathy in the tyrosine-fed rat.
Topics: Animals; Cornea; Corneal Opacity; Corneal Ulcer; Diet; Disease Models, Animal; Edema; Epithelium; Female; Neutrophils; Rats; Regeneration; Tyrosine | 1974 |
Neuronal lesions in the cerebellum following the administration of excess phenylalanine to neonatal rats.
Topics: Animals; Animals, Newborn; Axons; Cerebellum; Cytoplasm; Cytoplasmic Granules; Disease Models, Animal; Female; Humans; Liver; Myelin Sheath; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Purkinje Cells; Rats; Tyrosine | 1973 |
[Experimental hyperphenylalanaemic animals and cystathionine contents in brain tissues].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Brain Chemistry; Diet; Dipeptides; Disease Models, Animal; Haplorhini; Hydro-Lyases; L-Serine Dehydratase; Male; Metabolic Diseases; Mixed Function Oxygenases; Phenylacetates; Phenylalanine; Phenylpyruvic Acids; Rats; Swine; Tyrosine | 1970 |
Effects of 3-nitro-L-tyrosine on thyroid function in the rat: an experimental model for the dehalogenase defect.
Topics: Administration, Oral; Animals; Blood Proteins; Chromatography, Paper; Diet; Diiodotyrosine; Disease Models, Animal; Hydrolases; Hypothyroidism; Injections, Intraperitoneal; Iodides; Iodine; Iodine Isotopes; Male; Monoiodotyrosine; Nitro Compounds; Organ Size; Protein Binding; Radioimmunoassay; Rats; Rats, Inbred Strains; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Tyrosine | 1971 |
[Distribution of parenterally administered C 14 -hyaluronidase in the organs and tissues in experimental arteriosclerosis].
Topics: Animals; Aorta; Arteriosclerosis; Blood Proteins; Brain; Carbon Isotopes; Diet, Atherogenic; Disease Models, Animal; Fibrin; Hyaluronoglucosaminidase; Kidney; Liver; Male; Methods; Muscles; Myocardium; Pancreas; Rats; Tendons; Time Factors; Tyrosine | 1971 |
Alterations of individual free amino acids in brain during acute hepatic coma.
Topics: Amino Acids; Animals; Brain Chemistry; Cerebral Cortex; Disease Models, Animal; Dogs; Hepatic Encephalopathy; Histidine; Liver; Models, Biological; Nitrogen; Phenylalanine; Tryptophan; Tyrosine; Water | 1970 |
Decreased binding of 14C-homogentisic acid induced by ascorbic acid in connective tissue of rats with experimental alcaptonuria.
Topics: Alkaptonuria; Ascorbic Acid; Binding Sites; Carbon Isotopes; Connective Tissue; Disease Models, Animal; Ochronosis; Penicillamine; Phenylacetates; Sternum; Tendons; Tyrosine | 1970 |
Norepinephrine metabolism in brainstem of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain Stem; Carboxy-Lyases; Catecholamines; Central Nervous System; Desoxycorticosterone; Disease Models, Animal; Hypertension; Kidney; Male; Mesenteric Arteries; Mixed Function Oxygenases; Norepinephrine; Rats; Telencephalon; Tyrosine | 1970 |
Cerebral lipid metabolism in experimental hyperphenylalaninaemia: incorporation of 14C-labelled glucose into total lipids.
Topics: Animals; Animals, Newborn; Brain; Carbon Isotopes; Disease Models, Animal; Glucose; Humans; In Vitro Techniques; Lipids; Phenylacetates; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids; Rats; Tyrosine | 1970 |