tyrosine has been researched along with Degenerative Diseases, Central Nervous System in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 22 (53.66) | 29.6817 |
| 2010's | 12 (29.27) | 24.3611 |
| 2020's | 6 (14.63) | 2.80 |
| Authors | Studies |
|---|---|
| Anwar, S; Hasan, GM; Hassan, MI; Islam, A; Shahwan, M | 1 |
| Alves, R; Delaspre, F; Medina-Carbonero, M; Pazos-Gil, M; Sanz-Alcázar, A; Tamarit, J | 1 |
| Ai, P; He, X; Lai, Y; Mo, C; Qian, Y; Song, Y; Xiao, Q; Xu, S; Yan, Z; Yang, X; Zhang, Y | 1 |
| Du, C; Shu, L; Zuo, Y | 1 |
| Dignon, GL; Fawzi, NL; Hart, AC; Lins, J; Mittal, J; Naik, MT; Perdikari, TM; Ryan, VH; Saueressig, CF | 1 |
| Bailey, WM; Gensel, JC; McFarlane, KE; Patel, SP; Slone, SA; Stewart, AN; Sullivan, PG; Tranthem, LA; Vekaria, HJ; Zhang, B | 1 |
| Assaf, Y; Giladi, E; Gozes, I; Jouroukhin, Y; Ostritsky, R; Pelled, G | 1 |
| Gramage, E; Herradón, G; Pérez-García, C; Vicente-Rodríguez, M | 1 |
| Bett, C; Eisenberg, D; Jiang, L; Kurt, TD; Sigurdson, CJ | 1 |
| Alvarez, AR; Balboa, E; Bosch-Morató, M; Castro, JF; Chamorro, D; Contreras, P; Marín, T; Muñoz, FJ; Zanlungo, S | 1 |
| Alves, R; Andreotti, DZ; Böhmer, AE; de Sá Lima, L; Kawamoto, EM; Kinoshita, PF; Marcourakis, T; Marques Orellana, AM; Scavone, C; Vasconcelos, AR; Yshii, LM | 1 |
| Ding, N; Lu, X; Ng, SP; Qiu, G; Wu, CL | 1 |
| Ashworth, BE; Bartlett, CA; Fitzgerald, M; Giacci, MK; Hart, NS; Serghiou, S; Stephens, E; Williams, A | 1 |
| Ugrumov, MV | 1 |
| Kim, JK; Kim, KP; Lee, JR; Lee, SJ | 1 |
| Bing, G; Cass, WA; Choi, DY; Gash, DM; Hunter, RL; Kim, HC; Liu, M; Pandya, JD; Sullivan, PG | 1 |
| Balazy, M; Chemtob, S; Hamel, D; Hardy, P; Honoré, JC; Hou, X; Jankov, RP; Kooli, A; Mancini, JA; Picard, E; Rivera, JC; Tremblay, S; Varma, DR | 1 |
| da Rocha, RF; de Oliveira, MR; Moreira, JC; Schnorr, CE | 1 |
| Fales-Williams, AJ; Ghosh, A; Haynes, JS; Kanthasamy, AG; Wong, DM | 1 |
| Del Sole, R; Lazzoi, MR; Mergola, L; Scorrano, S; Vasapollo, G | 1 |
| Kochman, A; Kośka, C; Metodiewa, D | 1 |
| Drazba, J; Gaivin, R; Gonzalez-Cabrera, P; McCune, DF; Papay, R; Perez, DM; Ross, SA; Yun, J; Zuscik, MJ | 1 |
| Capaldi, RA; Ghosh, SS; Murray, J; Taylor, SW; Zhang, B | 1 |
| Chiu, LY; Rameau, GA; Ziff, EB | 1 |
| Anderson, PJ; Dickinson, PJ; LeCouteur, RA; Morris, JG; Powell, HC; Shelton, GD; Williams, DC | 1 |
| Farina, V; Gadau, S; Lepore, G; Manca, P; Zedda, M | 1 |
| Carrasco, J; Florit, S; Giralt, M; Hidalgo, J; Molinero, A; Penkowa, M; Quintana, A | 1 |
| Bhaskar, K; Lee, G; Yen, SH | 1 |
| Akaike, A; Hayashi, K; Inden, M; Kitamura, Y; Kondo, J; Nishimura, K; Shimohama, S; Sugimoto, H; Takata, K; Taniguchi, T; Tsuchiya, D; Yanagida, T; Yanagisawa, D | 1 |
| Bruchas, MR; Chavkin, C; Ippolito, DL; Wickman, K; Xu, M | 1 |
| Endo, F; Kimoto, Y; Matsumoto, S; Nakamura, K; Tanaka, Y; Tanoue, A; Tsujimoto, G | 1 |
| Schöneich, C | 1 |
| Abdul, HM; Ansari, MA; Butterfield, DA; Huang, Q; Joshi, G; Opii, WO; Sultana, R | 1 |
| Khanna, S; Park, HA; Roy, S; Sen, CK | 1 |
| Perry, G; Sayre, LM; Smith, MA | 1 |
| Chen, Q; Giasson, BI; Ischiropoulos, H; Lee, VM; Souza, JM | 1 |
| Chen, Q; Duda, JE; Giasson, BI; Hurtig, HI; Ischiropoulos, H; Lee, VM; Murray, IV; Souza, JM; Trojanowski, JQ | 1 |
| Chen, Q; Duda, JE; Giasson, BI; Gollomp, SM; Gur, TL; Hurtig, HI; Ischiropoulos, H; Lee, VM; Stern, MB; Trojanowski, JQ | 1 |
| Atwood, CS; Avila, J; Espey, MG; Perry, G; Smith, MA; Wink, DA | 1 |
| Bauer, JA; Mihm, MJ; Schanbacher, BL; Uretsky, NJ; Wallace, BL; Wallace, LJ | 1 |
| Hayes, EL; Kanterewicz, BI; Klann, E; Knapp, LT | 1 |
5 review(s) available for tyrosine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Humans; Microtubules; Neoplasms; Neurodegenerative Diseases; NF-kappa B; Phosphates; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Serine; Threonine; TOR Serine-Threonine Kinases; Tyrosine | 2022 |
[Synthesis of monoamines by non-monoaminergic neurons: illusion or reality?].
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Corpus Striatum; Dopamine; Humans; Hypothalamus; Levodopa; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Serotonin; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2009 |
Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis.
Topics: Animals; Atherosclerosis; Cardiovascular Diseases; CD40 Ligand; Humans; Neurodegenerative Diseases; Nitric Oxide; Protein Processing, Post-Translational; Proteins; Proteomics; Receptors, LDL; Tyrosine | 2009 |
Submolecular adventures of brain tyrosine: what are we searching for now?
Topics: Brain Chemistry; Dopamine; Free Radicals; Humans; Molecular Structure; Neurodegenerative Diseases; Reactive Oxygen Species; Tyrosine | 2002 |
Protein modification in aging: an update.
Topics: Aging; Histidine; Humans; Lamin Type A; Neurodegenerative Diseases; Nuclear Proteins; Oxidation-Reduction; Progeria; Protein Precursors; Protein Processing, Post-Translational; Pyruvaldehyde; Transglutaminases; Tyrosine | 2006 |
1 trial(s) available for tyrosine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Effect of
Topics: Constipation; Gastrointestinal Microbiome; Humans; Lacticaseibacillus; Lacticaseibacillus casei; Lacticaseibacillus paracasei; Neurodegenerative Diseases; Parkinson Disease; Probiotics; Tyrosine | 2023 |
35 other study(ies) available for tyrosine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Evolution of an Iron-Detoxifying Protein: Eukaryotic and
Topics: Bacterial Proteins; Escherichia coli; Escherichia coli Proteins; Eukaryota; Frataxin; Friedreich Ataxia; Humans; Iron; Iron-Binding Proteins; Mitochondria; Neurodegenerative Diseases; Rickettsia; Tyrosine | 2022 |
Abnormal phosphorylation of protein tyrosine in neurodegenerative diseases.
Topics: Humans; Neurodegenerative Diseases; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 2023 |
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cytoplasmic Granules; Disease Models, Animal; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Heterogeneous-Nuclear Ribonucleoprotein Group F-H; Humans; Microtubule-Associated Proteins; Models, Molecular; Mutation; Nerve Degeneration; Neurodegenerative Diseases; Phosphorylation; Protein Conformation; Protein Domains; Tyrosine | 2021 |
Mitochondria exert age-divergent effects on recovery from spinal cord injury.
Topics: 2,4-Dinitrophenol; Aging; Animals; Cell Survival; Disease Progression; Female; Mice; Mice, Inbred C57BL; Mitochondria; Neurodegenerative Diseases; Neurons; Oxidative Stress; Oxygen Consumption; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries; Tyrosine; Uncoupling Agents | 2021 |
NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axonal Transport; Blotting, Western; Body Weight; Brain; Contrast Media; Disease Progression; Female; Magnetic Resonance Imaging; Male; Manganese; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroprotective Agents; Oligopeptides; Phosphorylation; Psychomotor Performance; Spinal Cord; tau Proteins; Tubulin; Tyrosine; Ventral Tegmental Area | 2013 |
Phosphoproteomic analysis of the striatum from pleiotrophin knockout and midkine knockout mice treated with cocaine reveals regulation of oxidative stress-related proteins potentially underlying cocaine-induced neurotoxicity and neurodegeneration.
Topics: Animals; Blotting, Western; Carrier Proteins; Chromatography, Affinity; Cocaine; Cytokines; Electrophoresis, Polyacrylamide Gel; Mice; Mice, Knockout; Midkine; Neostriatum; Neurodegenerative Diseases; Neurotoxicity Syndromes; Oxidative Stress; Phosphoproteins; Phosphorylation; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2013 |
A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC.
Topics: Amyloid; Animals; Cell-Free System; Mice; Mutagenesis, Site-Directed; Mutation; Neurodegenerative Diseases; Prion Diseases; Prion Proteins; Prions; Protein Binding; Protein Structure, Tertiary; PrPC Proteins; Tyrosine | 2014 |
Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice.
Topics: alpha-Tocopherol; Animals; Caspase 3; Cell Line; Cell Survival; Dietary Supplements; Disease Models, Animal; DNA-Binding Proteins; Lysosomes; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurodegenerative Diseases; Niemann-Pick Disease, Type C; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Proteins c-abl; Signal Transduction; Tumor Protein p73; Tumor Suppressor Proteins; Tyrosine; Vitamin E | 2014 |
Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus.
Topics: Aging; Animals; Fasting; Hippocampus; Lipopolysaccharides; Male; Neurodegenerative Diseases; Neurogenic Inflammation; Nitric Oxide; Nitric Oxide Synthase; Nucleotides, Cyclic; Oxidative Stress; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thiobarbiturates; Tyrosine | 2015 |
Label-free detection of 3-nitro-l-tyrosine with nickel-doped graphene localized surface plasmon resonance biosensor.
Topics: Biomarkers; Enzyme-Linked Immunosorbent Assay; Gold; Graphite; Humans; Limit of Detection; Nanostructures; Neurodegenerative Diseases; Nickel; Surface Plasmon Resonance; Tyrosine | 2017 |
Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Immunohistochemistry; Infrared Rays; Mice; Microscopy, Confocal; Neurodegenerative Diseases; Oxidative Stress; Phototherapy; Random Allocation; Rats; Spinal Cord; Spinal Cord Injuries; Tissue Culture Techniques; Tyrosine | 2016 |
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.
Topics: alpha-Synuclein; Animals; Caspase 3; CD11b Antigen; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Electrochemistry; Encephalitis; Gene Expression Regulation; Male; Mitochondria; Neurodegenerative Diseases; Oxidative Stress; Rats; Rats, Inbred F344; Rotarod Performance Test; Solvents; Substantia Nigra; Trichloroethylene; Tyrosine; Tyrosine 3-Monooxygenase | 2010 |
Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress.
Topics: Animals; Animals, Newborn; Brain; Hypercapnia; Neurodegenerative Diseases; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Nitroarginine; Oxygen; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
L-NAME cotreatment did prevent neither mitochondrial impairment nor behavioral abnormalities in adult Wistar rats treated with vitamin A supplementation.
Topics: alpha-Synuclein; Animals; Anxiety Disorders; Behavior, Animal; Central Nervous System; Dietary Supplements; Diterpenes; Electron Transport; Glutathione Transferase; Heat-Shock Proteins; Illness Behavior; Locomotion; Male; Manganese; Mitochondria; Monoamine Oxidase; Neurodegenerative Diseases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Dopamine; Receptors, Immunologic; Retinyl Esters; Superoxide Dismutase; Superoxides; Tyrosine; Vitamin A | 2012 |
Evidence of oxidative injury of the spinal cord in 2 horses with equine degenerative myeloencephalopathy.
Topics: Aldehydes; Animals; Ataxia; Brain Diseases; Central Nervous System; Female; Horse Diseases; Horses; Immunohistochemistry; Neurodegenerative Diseases; Oxidative Stress; Spinal Cord Diseases; Tyrosine; Vitamin E; Vitamin E Deficiency | 2012 |
Developments in the synthesis of a water compatible molecularly imprinted polymer as artificial receptor for detection of 3-nitro-L-tyrosine in neurological diseases.
Topics: Biocompatible Materials; Biomarkers; Biomimetic Materials; Biosensing Techniques; Equipment Design; Equipment Failure Analysis; Humans; Molecular Imprinting; Neurodegenerative Diseases; Polymers; Reproducibility of Results; Sensitivity and Specificity; Tyrosine; Water | 2013 |
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.
Topics: Adrenergic alpha-Antagonists; alpha-Synuclein; Animals; Body Weight; Brain; Cerebellum; Disease Models, Animal; Female; Inclusion Bodies; Macromolecular Substances; Male; Mice; Mice, Transgenic; Motor Activity; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nitrates; Oligodendroglia; Phosphorylation; Prazosin; Receptors, Adrenergic, alpha-1; Spinal Cord; Survival Rate; Synucleins; Tyrosine; Ubiquitin | 2002 |
Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.
Topics: Amino Acid Sequence; Animals; Cattle; Electron Transport Complex I; Humans; Mass Spectrometry; Molecular Sequence Data; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Protein Subunits; Tyrosine | 2003 |
NMDA receptor regulation of nNOS phosphorylation and induction of neuron death.
Topics: Animals; Apoptosis; Calcineurin; Calcineurin Inhibitors; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Situ Nick-End Labeling; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphoprotein Phosphatases; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2003 |
Assessment of the neurologic effects of dietary deficiencies of phenylalanine and tyrosine in cats.
Topics: Amino Acids, Essential; Animal Nutritional Physiological Phenomena; Animals; Cat Diseases; Cats; Electromyography; Hair Color; Microscopy, Electron, Scanning; Muscle, Skeletal; Neural Conduction; Neurodegenerative Diseases; Nutritional Requirements; Peroneal Nerve; Phenylalanine; Tyrosine | 2004 |
Morphological and functional changes induced by the amino acid analogue 3-nitrotyrosine in mouse neuroblastoma and rat glioma cell lines.
Topics: Animals; Cell Division; Cell Line; Cell Nucleus; Cell Size; Cell Survival; Dose-Response Relationship, Drug; Glioma; Mice; Neuroblastoma; Neurodegenerative Diseases; Neuroglia; Neurons; Rats; Tubulin; Tyrosine | 2004 |
Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Astrocytes; Cell Count; Cell Death; Central Nervous System Diseases; Epilepsy; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Growth Substances; Guanine; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Interleukins; Kainic Acid; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Neurofibrillary Tangles; Staining and Labeling; Tyrosine | 2005 |
Disease-related modifications in tau affect the interaction between Fyn and Tau.
Topics: Alternative Splicing; Alzheimer Disease; Amino Acid Motifs; Animals; Exons; Genes, Dominant; Glutathione Transferase; Humans; Immunohistochemistry; Kinetics; Mice; Mice, Transgenic; Microtubules; Models, Genetic; Mutation; Mutation, Missense; Neurodegenerative Diseases; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; src Homology Domains; Surface Plasmon Resonance; tau Proteins; Time Factors; Tyrosine | 2005 |
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.
Topics: Adrenergic Agents; Aldehydes; alpha-Synuclein; Animals; Behavior, Animal; Blotting, Western; CD11b Antigen; Cell Count; Cell Line; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Functional Laterality; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Neurodegenerative Diseases; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Parkinsonian Disorders; Rats; Rats, Wistar; Reactive Oxygen Species; Rotarod Performance Test; Rotation; Substantia Nigra; Synaptophysin; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress.
Topics: Animals; Anisomycin; Antibodies; Behavior; Blotting, Western; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; DNA; Dose-Response Relationship, Drug; Electrophysiology; Enzyme-Linked Immunosorbent Assay; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Heart Atria; Heart Ventricles; Humans; Immunoblotting; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Fluorescence; Muscle Cells; Neurodegenerative Diseases; Neurons; NIH 3T3 Cells; Phosphorylation; Plasmids; Protein Structure, Tertiary; Sciatic Nerve; Spinal Cord; Stress, Physiological; Tyrosine; Xenopus laevis | 2005 |
Gene expression profiles of homogentisate-treated Fah-/- Hpd-/-mice using DNA microarrays.
Topics: Animals; Apoptosis; Caspases; Down-Regulation; Female; Gene Expression Profiling; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hydrolases; Liver; Mice; Mice, Mutant Strains; Neurodegenerative Diseases; Oligonucleotide Array Sequence Analysis; Oxidoreductases; Porphobilinogen Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA; Smad7 Protein; Tyrosine; Tyrosinemias; Up-Regulation | 2006 |
In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidativ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Brain; Bridged-Ring Compounds; Cytochromes c; Gerbillinae; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Injections, Intraperitoneal; Lipid Peroxidation; Male; Mitochondria; Neurodegenerative Diseases; Neuroprotective Agents; Norbornanes; Oxidation-Reduction; Oxidative Stress; Thiocarbamates; Thiones; Type C Phospholipases; Tyrosine | 2006 |
Regulation of c-Src activity in glutamate-induced neurodegeneration.
Topics: Animals; Caveolin 1; Cell Survival; Cells, Cultured; CSK Tyrosine-Protein Kinase; Glutamic Acid; Mice; Models, Biological; Neurodegenerative Diseases; Neurons; Phosphorylation; Protein Transport; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; src-Family Kinases; Tyrosine | 2007 |
In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders.
Topics: Aldehydes; Alzheimer Disease; Analysis of Variance; Biomarkers; DNA Damage; Glycation End Products, Advanced; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Histocytochemistry; Humans; Iron; Membrane Proteins; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Nitrates; Oxidation-Reduction; Oxidative Stress; Oxygen; Phenylhydrazines; Plaque, Amyloid; Tyrosine | 1999 |
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.
Topics: alpha-Synuclein; Electrophoresis, Polyacrylamide Gel; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitrates; Oxidative Stress; Polymers; Recombinant Proteins; Synucleins; Tyrosine | 2000 |
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.
Topics: alpha-Synuclein; Alzheimer Disease; Antibodies, Monoclonal; Blotting, Western; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Lewy Bodies; Lewy Body Disease; Microscopy, Immunoelectron; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oxidative Stress; Parkinson Disease; Synucleins; Tyrosine | 2000 |
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Antibodies; Blotting, Western; Brain Diseases; Female; Humans; Immunohistochemistry; Inclusion Bodies; Lewy Bodies; Male; Middle Aged; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglia; Nitrates; Synucleins; Tissue Distribution; Tyrosine | 2000 |
Biochemistry of neurodegeneration.
Topics: Antibodies, Monoclonal; Brain; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oxidative Stress; Synucleins; Tyrosine | 2001 |
Free 3-nitrotyrosine causes striatal neurodegeneration in vivo.
Topics: Animals; Cell Count; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Immunohistochemistry; Mice; Motor Activity; Neurodegenerative Diseases; Neurons; Oxidopamine; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2001 |
Peroxynitrite-induced tyrosine nitration and inhibition of protein kinase C.
Topics: Animals; Brain; Cysteine; Isoenzymes; Male; Neurodegenerative Diseases; Nitrates; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; Penicillamine; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Tissue Extracts; Tyrosine | 2001 |