Compounds > tyrosine

tyrosine and Colorectal Neoplasms

tyrosine has been researched along with Colorectal Neoplasms in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (8.89)18.2507
2000's16 (35.56)29.6817
2010's16 (35.56)24.3611
2020's9 (20.00)2.80

Authors

AuthorsStudies
Clerici, SP; de Lima, TI; Durán, N; Faria, AVS; Fernandes-Oliveira, PS; Ferreira-Halder, CV; Fonseca, EMB; Justo, GZ; Silveira, LR1
Bitner, L; Johnson, B; Jones, P; Kanikarla Marie, P; Kopetz, S; Kwong, LN; Lee, MS; Manyam, G; Menter, DG; Morris, VK; Sorokin, AV; Syed, M; Woods, M1
Heo, CY; Jeong, JH; Kim, HY; Lee, S; Yun, JW1
Cui, Z; Du, Y; Feng, X; Gao, R; He, R; Hu, H; Liang, S; Ma, X; Pan, T; Peng, Q; Sun, W; Wang, C; Wang, H; Yi, M; Zhang, H1
Akiyama, Y; Endo, Y; Hara, Y; Hirotani, K; Imaida, T; Masuko, K; Masuko, T; Miyake, R; Okazaki, S; Okita, K; Okuno, H; Tomioka, Y; Yamasaki, A1
Govindarajan, V; Kuracha, MR; Loggie, BW; McVicker, BL; Tobi, M1
Fleszar, MG; Fortuna, P; Kosyk, B; Krzystek-Korpacka, M; Zawadzki, M1
Flower, CT; Gajadhar, AS; Gallien, S; Lopez-Ferrer, D; Patel, B; Stopfer, LE; White, FM1
Alexeev, EE; Cartwright, IM; Colgan, SP; Dowdell, AS; Henen, MA; Lanis, JM; Lee, JS; Onyiah, JC; Ornelas, A; Schaefer, REM; Vögeli, B1
Ji, J; Ji, Y; Tang, Z; Tian, Y; Yang, C; Yang, Y; Yao, H; Zhang, Z; Zheng, X; Zhu, X1
Chen, B; Chen, S; Hou, Z; Jiang, Z; Li, Y; Lin, Z; Wang, Y; Zhou, T1
Fujinaga, T; Hayashi, Y; Hiyama, S; Honma, K; Iijima, H; Maekawa, A; Mizushima, T; Morii, E; Nagai, K; Sakatani, A; Shinzaki, S; Takehara, T; Tsujii, M; Tsujii, Y; Watabe, K; Yoshii, S1
Arinze, N; Belghasem, M; Chitalia, VC; Cifuentes, D; Francis, J; Ghumman, S; Hartshorn, K; Jiangliu, Y; Kolachalama, VB; Kuhnen, A; Kumaradevan, S; Lee, SY; Lyle, C; Rahimi, N; Richards, S; Tapan, U; Walker, J; Weinberg, J; Zhao, Q1
Chakrabandhu, K; Huault, S; Hueber, AO; Ta, NL1
Lai, M; Li, J; Qi, LW; Wang, H; Zhu, Y1
Ding, LD; Jia, BQ; Li, YR; Liu, HY; Wang, YY; Zhang, BD1
Chalkiadakis, G; Chrysos, E; Lasithiotakis, K; Pappas-Gogos, G; Tellis, C; Tselepis, AD; Tsimogiannis, K; Tsimoyiannis, E1
Barbosa, MA; Cardoso, AP; Figueiredo, C; Gonçalves, R; Mantovani, A; Mareel, M; Oliveira, MI; Oliveira, MJ; Pinto, AT; Pinto, ML; Pinto, MT; Relvas, JB; Seruca, R1
Aldasoro, M; Fernández, N; Ferrero, E; Ferrero, JL; García-Villalón, AL; García-Villar, O; Granado, M; Hidalgo, M; Mauricio, MD; Monge, L; Vila, JM1
Ghishan, FK; Jagadish, B; Kiela, PR; Kojs, P; Martinez, JD; Mash, EA; Radhakrishnan, VM; Ramalingam, R; Young, G1
Gu, L; Lee, S; Li, GM; Li, JY; Ortega, J; Tong, D1
Asano, M; Dawson, D; Guda, K; Iwakura, Y; Lawrence, E; Markowitz, SD; Satake, M; Sun, Q; Wang, Z; Watanabe, T; Wei, L; Willis, J; Yang, Z; Zhang, X; Zhao, Y; Zheng, W1
DuBois, RN; Guo, L; Ning, W; Wang, D; Xie, D1
Ahamed, MB; Aisha, AF; Ismail, Z; Majid, AM; Nassar, ZD; Omari, SM; Parish, CR; Siddiqui, JM1
Geng, SM; He, C; Kuang, YY; Lao, WF; Mo, LJ; Wang, D1
Abounader, R; Ellis, LM; Gallick, GE; Herynk, MH; Laterra, J; Parikh, NU; Radinsky, R; Reinmuth, N; Stoeltzing, O1
Gallick, GE; Herynk, MH; Radinsky, R; Tsan, R1
Marx, JJ; Peeters, PH; Roest, M; van der A, DL; van der Hel, O; van der Schouw, YT; van Gils, CH; van Noord, PA1
Anselmi, L; Arrigoni, A; Bertario, L; Bonelli, L; Bruzzi, P; Fornasarig, M; Gentile, M; Gismondi, V; Mareni, C; Meta, M; Ponz de Leon, M; Radice, P; Sala, P; Varesco, L; Viel, A1
Bardelli, A; Kinzler, KW; Markowitz, S; Parmigiani, G; Parsons, DW; Peters, BA; Powell, SM; Ptak, J; Riggins, G; Sager, J; Shen, D; Silliman, N; Szabo, S; van der Heijden, MS; Velculescu, VE; Vogelstein, B; Wang, TL; Wang, Z; Willson, JK; Yan, H1
Bertagnolli, MM; Carothers, AM; Hunt, DH; Javid, SH; Moran, AE; Redston, M1
Aronson, M; Cleary, SP; Cotterchio, M; Croitoru, ME; Di Nicola, N; Gallinger, S; Gryfe, R; Knight, J; Manno, M; Redston, M; Selander, T1
Kucerová, D; Sloncová, E; Tuhácková, Z; Turecková, J; Vojtechová, M1
Delfino, FJ; Smithgall, TE; Stevenson, H1
Benati, D; Coluccia, AM; De Filippo, A; Dekhil, H; Gambacorti-Passerini, C; Lan, C1
Chen, Y; Guo, A; Kinzler, KW; Polakiewicz, RD; Possemato, A; Velculescu, VE; Vogelstein, B; Wang, ZJ; Yu, J; Zhang, X; Zheng, W1
Bouancheau, D; Denis, MG; Jarry, A; Laboisse, CL; Masson, D; Mosnier, JF; Mottier, S; Toquet, C1
Benamouzig, R; Breau, JL; Des Guetz, G; Fagard, R; Hbibi, AT; Lagorce, C; Martin, A; Milano, G; Morere, JF; Rixe, O; Spano, JP; Wind, P1
Homma, MK; Homma, Y; Namba, M; Yuasa, Y1
Chen, Z; Delbaere, LT; Liu, E; Luo, X; Qi, Y; Rathgeber, C; Xiang, J1
Kim, YS; Lamprecht, SA; Niv, Y; Polak-Charcon, S; Schwartz, B1
Buttenshaw, RL; Johnson, AG; Leggett, BA; Macdonald, GA; McCann, SJ; Mellick, GD; Tarish, J; Whitehall, VJ; Young, J1
Askham, JM; Clissold, PM; Coletta, PL; Markham, AF; McCall, SH; Meredith, DM; Moncur, P; Morrison, EE; Norris, AL1
Hajer, J; Kepelová, A; Kment, M; Zádorová, Z1
Echizenya, M; Hiai, H; Imamura, M; Kondo, S; Onodera, H; Ozeki, M; Tachibana, T; Toyokuni, S; Tsuruyama, T1

Trials

2 trial(s) available for tyrosine and Colorectal Neoplasms

ArticleYear
c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation.
    The American journal of pathology, 2018, Volume: 188, Issue:8

    Topics: Animals; Apoptosis; beta Catenin; Biomarkers, Tumor; Case-Control Studies; Cell Proliferation; Colorectal Neoplasms; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutation; Neovascularization, Pathologic; Phosphorylation; Prognosis; Proto-Oncogene Mas; Proto-Oncogene Proteins c-cbl; Survival Rate; Tumor Cells, Cultured; Tyrosine; Wnt1 Protein; Zebrafish

2018
Oxidative stress markers in laparoscopic versus open colectomy for cancer: a double-blind randomized study.
    Surgical endoscopy, 2013, Volume: 27, Issue:7

    Topics: Aged; Analysis of Variance; Biomarkers; Colectomy; Colorectal Neoplasms; Dinoprost; Double-Blind Method; Female; Guanosine; Humans; Laparoscopy; Male; Oxidative Stress; Postoperative Period; Protein Carbonylation; Tyrosine

2013

Other Studies

43 other study(ies) available for tyrosine and Colorectal Neoplasms

ArticleYear
Violacein switches off low molecular weight tyrosine phosphatase and rewires mitochondria in colorectal cancer cells.
    Bioorganic chemistry, 2022, Volume: 127

    Topics: Colorectal Neoplasms; Humans; Indoles; Male; Mitochondria; Molecular Weight; Protein Tyrosine Phosphatases; Tyrosine

2022
Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6.
    Cancer research, 2022, Sep-16, Volume: 82, Issue:18

    Topics: Cell Line, Tumor; Colorectal Neoplasms; Cyclin-Dependent Kinase 4; Humans; Mitogen-Activated Protein Kinase Kinases; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Tyrosine; Xenograft Model Antitumor Assays

2022
Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Axin Protein; Colorectal Neoplasms; Crizotinib; ErbB Receptors; Humans; Receptor Protein-Tyrosine Kinases; Receptor-Like Protein Tyrosine Phosphatases, Class 2; RNA; Signal Transduction; Thrombospondins; Tumor Suppressor Protein p53; Tyrosine

2022
RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells.
    Journal of immunology (Baltimore, Md. : 1950), 2022, 11-01, Volume: 209, Issue:9

    Topics: Animals; Carcinogenesis; Colorectal Neoplasms; Cytokines; Epithelial Cells; Humans; Mice; Receptor, EphA1; Receptor, EphB2; Signal Transduction; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases

2022
Dual-targeting therapy against HER3/MET in human colorectal cancers.
    Cancer medicine, 2023, Volume: 12, Issue:8

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Humans; Mice; Mice, Nude; Signal Transduction; Tyrosine

2023
Pictilisib-Induced Resistance Is Mediated through FOXO1-Dependent Activation of Receptor Tyrosine Kinases in Mucinous Colorectal Adenocarcinoma Cells.
    International journal of molecular sciences, 2023, Aug-02, Volume: 24, Issue:15

    Topics: Adenocarcinoma; Colorectal Neoplasms; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Tyrosine

2023
Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period.
    Molecules (Basel, Switzerland), 2020, Nov-05, Volume: 25, Issue:21

    Topics: Aged; Biomarkers; Chromatography, Liquid; Colorectal Neoplasms; Female; Humans; Inflammation; Male; Metabolomics; Middle Aged; Nitrosative Stress; Oxidative Stress; Postoperative Complications; Postoperative Period; Prospective Studies; Reactive Oxygen Species; Reproducibility of Results; Sensitivity and Specificity; Surgical Wound Infection; Tandem Mass Spectrometry; Tyrosine

2020
High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors.
    Cancer research, 2021, 05-01, Volume: 81, Issue:9

    Topics: A549 Cells; CD8-Positive T-Lymphocytes; Chromatography, Liquid; Colorectal Neoplasms; ErbB Receptors; Humans; Mass Spectrometry; Phosphopeptides; Phosphorylation; Protein Interaction Maps; Protein Processing, Post-Translational; Proteome; Proteomics; Signal Transduction; Tyrosine

2021
Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:5

    Topics: Adenocarcinoma; Animals; Bystander Effect; Colitis; Colorectal Neoplasms; Halogenation; Humans; Indoles; Mice; Mice, Inbred C57BL; Microbiota; Neutrophils; Peroxidase; Tumor Cells, Cultured; Tyrosine

2021
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.
    Nature communications, 2017, 05-18, Volume: 8

    Topics: Animals; Antineoplastic Agents; Carcinogenesis; Colorectal Neoplasms; DNA-Binding Proteins; Doxycycline; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplastic Stem Cells; Nuclear Proteins; Phenotype; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Small Interfering; Tyrosine; Xenograft Model Antitumor Assays

2017
Ezrin/NF-kB activation regulates epithelial- mesenchymal transition induced by EGF and promotes metastasis of colorectal cancer.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 92

    Topics: Animals; Cell Movement; Colorectal Neoplasms; Cytoskeletal Proteins; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; Female; Humans; Male; Mice, Nude; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Neoplasm Transplantation; NF-kappa B; Phosphorylation; Prognosis; Protein Processing, Post-Translational; Recombinant Fusion Proteins; RNA Interference; Survival Analysis; Tumor Burden; Tyrosine

2017
Adenoma of colorectal laterally spreading tumor nongranular type with biological phenotypic features similar to cancer.
    Journal of gastroenterology and hepatology, 2018, Volume: 33, Issue:11

    Topics: Adenoma; Carcinogenesis; Cohort Studies; Colorectal Neoplasms; Fibrosis; Humans; Intestinal Mucosa; Ki-67 Antigen; Microvessels; Mucins; Neoplasm Invasiveness; Nitric Oxide Synthase Type II; Phenotype; Retrospective Studies; Tumor Suppressor Protein p53; Tyrosine

2018
The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway.
    Scientific reports, 2018, 08-20, Volume: 8, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Epidermal Growth Factor; ErbB Receptors; fas Receptor; HCT116 Cells; Humans; Neoplasm Recurrence, Local; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Tyrosine

2018
Tyrosine and Glutamine-Leucine Are Metabolic Markers of Early-Stage Colorectal Cancers.
    Gastroenterology, 2019, Volume: 157, Issue:1

    Topics: Aged; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Dipeptides; Female; Glutamine; Humans; Leucine; Male; Metabolic Syndrome; Metabolomics; Middle Aged; Neoplasm Staging; Principal Component Analysis; Spectrometry, Mass, Electrospray Ionization; Tyrosine

2019
Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer.
    Cancer science, 2019, Volume: 110, Issue:7

    Topics: Aged; Animals; Cell Line, Tumor; Cell Proliferation; Codon, Nonsense; Colorectal Neoplasms; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Lymphatic Metastasis; Male; Mice; Middle Aged; Phosphorylation; Prognosis; Protein Tyrosine Phosphatase, Non-Receptor Type 4; STAT3 Transcription Factor; Survival Analysis; Tyrosine

2019
Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity.
    Oncogene, 2014, Apr-17, Volume: 33, Issue:16

    Topics: Blotting, Western; Caco-2 Cells; Cell Line, Tumor; Cell Movement; Cells, Cultured; Coculture Techniques; Colorectal Neoplasms; ErbB Receptors; Humans; Macrophages; Matrix Metalloproteinases; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Stomach Neoplasms; Time-Lapse Imaging; Tyrosine

2014
Tyrosine phosphorylation modulates the vascular responses of mesenteric arteries from human colorectal tumors.
    BioMed research international, 2013, Volume: 2013

    Topics: Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Mesenteric Arteries; Neovascularization, Pathologic; Organ Culture Techniques; Phosphorylation; Tyrosine; Vanadates; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

2013
pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents; Blotting, Western; Catenins; Cell Line, Tumor; Cell Membrane; Cell Movement; Colorectal Neoplasms; Cortactin; Curcumin; Delta Catenin; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Immunohistochemistry; Microscopy, Confocal; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine

2014
Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, May-05, Volume: 112, Issue:18

    Topics: Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Progression; DNA; DNA Mismatch Repair; ErbB Receptors; Genome; Genome, Human; HeLa Cells; Humans; Microscopy, Fluorescence; Models, Molecular; Mutation; Neoplasms; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Binding; Sequence Analysis, DNA; Tyrosine

2015
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Feb-09, Volume: 107, Issue:6

    Topics: Animals; Azoxymethane; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Female; HCT116 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mutation; Neoplasms, Experimental; Paxillin; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Substrate Specificity; Transfection; Transplantation, Heterologous; Tyrosine

2010
Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.
    Oncogene, 2012, Feb-23, Volume: 31, Issue:8

    Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Fragmentation; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Inhibitor of Apoptosis Proteins; Oxazoles; PPAR delta; PPAR gamma; Survivin; Thiazoles; Tyrosine

2012
Cat's whiskers tea (Orthosiphon stamineus) extract inhibits growth of colon tumor in nude mice and angiogenesis in endothelial cells via suppressing VEGFR phosphorylation.
    Nutrition and cancer, 2012, Volume: 64, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Cell Proliferation; Chromatography, High Pressure Liquid; Colonic Neoplasms; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Nude; Orthosiphon; Phosphorylation; Plant Extracts; Plants, Medicinal; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2012
A novel variant of the RON receptor tyrosine kinase derived from colorectal carcinoma cells which lacks tyrosine phosphorylation but induces cell migration.
    Experimental cell research, 2012, Dec-10, Volume: 318, Issue:20

    Topics: Adenocarcinoma; Alternative Splicing; Cell Movement; Colorectal Neoplasms; Genetic Variation; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Phosphorylation; Receptor Protein-Tyrosine Kinases; Tyrosine

2012
Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells.
    Cancer research, 2003, Jun-01, Volume: 63, Issue:11

    Topics: Adenoviridae; Animals; Apoptosis; Cell Division; Cell Movement; Cell Survival; Colorectal Neoplasms; Down-Regulation; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Phosphorylation; Proto-Oncogene Proteins c-met; RNA, Catalytic; Transfection; Tyrosine

2003
Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin.
    Clinical & experimental metastasis, 2003, Volume: 20, Issue:4

    Topics: beta Catenin; Blotting, Western; Cell Adhesion; Cell Movement; Colony-Forming Units Assay; Colorectal Neoplasms; Cyclin D1; Cytoskeletal Proteins; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-met; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine

2003
Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands).
    Cancer causes & control : CCC, 2003, Volume: 14, Issue:6

    Topics: Aged; Case-Control Studies; Cohort Studies; Colorectal Neoplasms; Cysteine; Female; Genotype; Hemochromatosis Protein; Heterozygote; Histocompatibility Antigens Class I; Humans; Membrane Proteins; Middle Aged; Mutation; Netherlands; Odds Ratio; Polymerase Chain Reaction; Prospective Studies; Risk Factors; Smoking; Tyrosine

2003
Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas.
    International journal of cancer, 2004, May-01, Volume: 109, Issue:5

    Topics: Adenine; Adenoma; Adenomatous Polyposis Coli; Adult; Aged; Aspartic Acid; Case-Control Studies; Colorectal Neoplasms; Cysteine; DNA Glycosylases; DNA Mutational Analysis; DNA, Neoplasm; Female; Gene Deletion; Gene Frequency; Germ-Line Mutation; Glycine; Guanine; Humans; Italy; Male; Middle Aged; Tyrosine

2004
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
    Science (New York, N.Y.), 2004, May-21, Volume: 304, Issue:5674

    Topics: Catalytic Domain; Cell Division; Codon, Nonsense; Colorectal Neoplasms; Computational Biology; DNA Mutational Analysis; Exons; Frameshift Mutation; Genes, Tumor Suppressor; Humans; Kinetics; Markov Chains; Mutation; Mutation, Missense; Nerve Tissue Proteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatase, Non-Receptor Type 3; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Signal Transduction; Transfection; Tyrosine

2004
Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.
    The Journal of biological chemistry, 2004, Oct-08, Volume: 279, Issue:41

    Topics: Adaptor Proteins, Signal Transducing; Adenoma; Adenomatous Polyposis Coli Protein; Alleles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Clathrin; Colorectal Neoplasms; Cyclooxygenase 2; Dinoprostone; Disease Progression; Enterocytes; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Genes, APC; HeLa Cells; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Intestinal Mucosa; Intestine, Small; Isoenzymes; Jurkat Cells; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recurrence; Signal Transduction; src-Family Kinases; Tissue Distribution; Transcriptional Activation; Tyrosine; Ubiquitin; Up-Regulation; Vanadates

2004
Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.
    Journal of the National Cancer Institute, 2004, Nov-03, Volume: 96, Issue:21

    Topics: Adenomatous Polyposis Coli; Aspartic Acid; Base Pair Mismatch; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Cysteine; DNA Glycosylases; DNA Mutational Analysis; DNA, Neoplasm; Gene Frequency; Genetic Predisposition to Disease; Germ-Line Mutation; Glycine; Humans; Loss of Heterozygosity; Ontario; Phenotype; Risk Factors; Tyrosine

2004
Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells.
    International journal of molecular medicine, 2006, Volume: 17, Issue:1

    Topics: Adenocarcinoma; Alkaline Phosphatase; Androstadienes; beta Catenin; Butyrates; Cell Line, Tumor; Colorectal Neoplasms; Humans; Immunohistochemistry; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Tyrosine; Wortmannin

2006
A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.
    The Journal of biological chemistry, 2006, Mar-31, Volume: 281, Issue:13

    Topics: Cell Line; Colorectal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Dominant; Green Fluorescent Proteins; HCT116 Cells; HT29 Cells; Humans; Immunoblotting; Immunohistochemistry; Models, Molecular; Mutation; Nerve Tissue Proteins; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fes; Recombinant Fusion Proteins; Retroviridae; RNA-Binding Proteins; Saccharomyces cerevisiae; STAT3 Transcription Factor; Tyrosine

2006
SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling.
    Cancer research, 2006, Feb-15, Volume: 66, Issue:4

    Topics: Aniline Compounds; beta Catenin; Cadherins; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cell Nucleus; Colorectal Neoplasms; Humans; Intercellular Junctions; Nitriles; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Quinolines; Signal Transduction; TCF Transcription Factors; Transcription Factor 7-Like 2 Protein; Transcriptional Activation; Tyrosine

2006
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Mar-06, Volume: 104, Issue:10

    Topics: Cell Line; Cell Line, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Mutation; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Signal Transduction; STAT3 Transcription Factor; Substrate Specificity; Tyrosine

2007
Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor gamma, in colorectal adenocarcinoma.
    Oncology reports, 2007, Volume: 18, Issue:2

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Alternative Splicing; Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Male; Middle Aged; Oxazoles; PPAR gamma; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine

2007
Identification of a functional EGF-R/p60c-src/STAT3 pathway in colorectal carcinoma: analysis of its long-term prognostic value.
    Cancer biomarkers : section A of Disease markers, 2008, Volume: 4, Issue:2

    Topics: Aged; Colorectal Neoplasms; ErbB Receptors; Humans; Immunohistochemistry; Neoplasm Staging; Phosphorylation; Prognosis; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; STAT3 Transcription Factor; Tissue Array Analysis; Tyrosine

2008
Enhanced phosphoinositide metabolism in colorectal carcinoma cells derived from familial adenomatous polyposis patients.
    Journal of cellular biochemistry, 1994, Volume: 55, Issue:4

    Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Cell Line; Chromatography, Affinity; Colorectal Neoplasms; Diglycerides; Electrophoresis, Polyacrylamide Gel; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotyrosine; RNA, Messenger; Second Messenger Systems; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine

1994
The tyrosine residue at position 97 in the VH CDR3 region of a mouse/human chimeric anti-colorectal carcinoma antibody contributes hydrogen bonding to the TAG72 antigen.
    Cancer biotherapy, 1993,Fall, Volume: 8, Issue:3

    Topics: Animals; Antibodies, Neoplasm; Antibody Affinity; Antigen-Antibody Reactions; Antigens, Neoplasm; Base Sequence; Colorectal Neoplasms; Glycoproteins; Humans; Hydrogen Bonding; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Fusion Proteins; Structure-Activity Relationship; Tyrosine

1993
Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation.
    Oncology research, 1995, Volume: 7, Issue:6

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaline Phosphatase; Benzylidene Compounds; Cell Differentiation; Cell Line; Colonic Neoplasms; Colorectal Neoplasms; Cytosol; Enzyme Inhibitors; Humans; Kinetics; Microscopy, Electron, Scanning; Nitriles; Phenols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins

1995
No evidence of increased risk of colorectal cancer in individuals heterozygous for the Cys282Tyr haemochromatosis mutation.
    Journal of gastroenterology and hepatology, 1999, Volume: 14, Issue:12

    Topics: Aged; Chi-Square Distribution; Colorectal Neoplasms; Cysteine; Electrophoresis, Polyacrylamide Gel; Female; Genes, MHC Class I; Hemochromatosis; Hemochromatosis Protein; Heterozygote; Histocompatibility Antigens Class I; HLA Antigens; Humans; Male; Membrane Proteins; Mutation; Polymerase Chain Reaction; Risk Factors; Tyrosine

1999
Truncated adenomatous polyposis coli (APC) tumour suppressor protein can undergo tyrosine phosphorylation.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:4

    Topics: Adenomatous Polyposis Coli Protein; Colorectal Neoplasms; Cytoskeletal Proteins; Genes, APC; Genetic Vectors; Humans; Mutagenesis, Site-Directed; Mutation; Neoplasm Proteins; Phosphorylation; Recombinant Proteins; Tyrosine

2000
Two novel germline mutations (Y548X and K732X) of the MLH1 gene in Czech patients with hereditary nonpolyposis colorectal cancer.
    Human mutation, 2000, Volume: 16, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Adult; Base Pair Mismatch; Carrier Proteins; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Female; Germ-Line Mutation; Humans; Lysine; Male; Molecular Sequence Data; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Polymorphism, Genetic; Tyrosine

2000
Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver.
    Cancer letters, 2002, May-08, Volume: 179, Issue:1

    Topics: Adenocarcinoma; Aged; Apoptosis; Cell Division; Colorectal Neoplasms; Female; Humans; Immunoenzyme Techniques; Liver Neoplasms; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidative Stress; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Tyrosine

2002