tyrosine has been researched along with Colonic Neoplasms in 105 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (7.62) | 18.7374 |
1990's | 21 (20.00) | 18.2507 |
2000's | 53 (50.48) | 29.6817 |
2010's | 20 (19.05) | 24.3611 |
2020's | 3 (2.86) | 2.80 |
Authors | Studies |
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Anzai, N; Furihata, T; Higuchi, K; Kaneko, M; Morio, H; Muto, Y; Nakagawa, K; Ohno, Y; Okunushi, K; Otsuka, Y; Reien, Y; Sakamoto, S; Shimojo, N; Wakashin, H; Watanabe, Y | 1 |
Chen, Y; He, X; Huang, X; Li, Y; Ma, K; Wei, W; Yang, X | 1 |
Friesel, R; Gauchat, JF; Girondel, C; Langlois, MJ; Lesage, S; Lévesque, K; Meloche, S; Pasquin, S; Rivard, N; Saba-El-Leil, MK; Servant, MJ | 1 |
Anzai, N; Furihata, T; Higuchi, K; Kaneko, M; Matsubara, H; Morio, H; Muto, Y; Okunushi, K; Reien, Y; Uesato, M | 1 |
Choi, S; Jang, B; Lee, ST; Lee, W; Oh, ES; Park, J; Shin, DH; Yun, JH | 1 |
Cao, Z; Chen, J; Gao, J; Huang, C; Huang, H; Li, J; Zhang, D; Zhang, J; Zhang, R | 1 |
Fujino, H; Murayama, T; Otake, S; Regan, JW; Seira, N; Yoshida, K | 1 |
Anastasiadis, PZ; Espejo, R; Honkus, K; Jeng, Y; Paulucci-Holthauzen, A; Rengifo-Cam, W; Sastry, SK | 1 |
Aragay, AM; Cordomí, A; Garrido, G; Gigoux, V; Izquierdo, I; Masià-Balagué, M; Miller, NL; Pérez-Benito, L; Schlaepfer, DD | 1 |
Ahmed, Z; Cook, NP; Gagea, M; Ladbury, JE; Lee, GR; Lin, CC; Marti, AA; Suen, KM; Timsah, Z | 1 |
Donnini, S; Giachetti, A; Terzuoli, E; Ziche, M | 1 |
Chen, J; Duan, Q; Fan, X; Shao, C; Sun, H; Wang, Z; Xiao, J; Xue, P; Yan, W; Zeng, X; Zhu, F | 1 |
Huang, J; Mei, W; Wang, K; Zheng, X | 1 |
Baillat, G; Delamarre, E; Luis, J; Siret, C | 1 |
Hao, X; Ju, J; Lambert, JD; Lee, MJ; Lu, G; Newmark, HL; Xiao, H; Yang, CS | 1 |
Hsieh, LL; Li, YY; Liao, SK; Tang, RP; Yeh, KY | 1 |
Amano, K; Kato, K; Nishiyama, K; Tachikawa, M; Urano, A; Yamanaka, K | 1 |
El Firar, A; Laburthe, M; Voisin, T | 1 |
Geng, M; Li, J; Peng, Y | 1 |
Ji, P; Kopelovich, L; Ouyang, N; Rigas, B; Williams, JL | 1 |
Kobayashi, D; Kuribayashi, K; Tanabe, H; Tanaka, M; Tsuji, N; Watanabe, N | 1 |
Endo, K; Hanaoka, H; Ishioka, NS; Ohshima, Y; Oriuchi, N; Sugo, Y; Tominaga, H; Watanabe, S | 1 |
Ahamed, MB; Aisha, AF; Ismail, Z; Majid, AM; Nassar, ZD; Omari, SM; Parish, CR; Siddiqui, JM | 1 |
Chen, YK; Guan, F; Lee, MJ; Li, G; Lin, Y; Liu, AB; Shih, W; Yang, CS; Yang, Z | 1 |
Blatt, A; Dahan, A; Elyakim, R; Gochman, E; Mahajna, J; Reznick, AZ; Shenzer, P | 1 |
Chakrabarti, MK; Karmakar, P | 1 |
Andersen, JH; Engh, RA; Genevière, AM; Hansen, E; Hanssen, KØ; Stiberg, T; Svenson, J | 1 |
Chen, ZY; Shie, JL; Tseng, CC | 1 |
Galanko, J; Keku, T; Lawrence, LB; Martin, CF; Rohlfs, EM; Sandler, RS; Shaheen, NJ; Silverman, LM | 1 |
Alaimo, G; Alessandro, R; Bauder, B; D'Amato, M; De Leo, G; Flugy, AM; Kohn, EC | 1 |
Benjannet, S; Chrétien, M; Khatib, AM; Seidah, NG; Siegfried, G | 1 |
Alessandro, R; D'Amato, M; De Leo, G; Di Bella, MA; Flugy, AM; Russo, D | 1 |
Benya, RV; Glover, S; Keller, K; Kornberg, L; Matkowskyj, KA; Tran-Son-Tay, R | 1 |
Cho, H; Hong, J; Im, KS; Jung, JH; Kim, DK; Lee, CO; Liu, Y; Park, Y | 1 |
Allen, JD; Boyd, G; Cummings, J; Friedberg, TH; Jodrell, DI; Maliepaard, M; Smyth, JF; Yao, D; Zelcer, N | 1 |
Otte, JM; Schmidt, WE; Schmitz, F; Schrader, H; Yu, HG | 1 |
Boyd, G; Burchell, B; Cummings, J; Ethell, BT; Jardine, L; Jodrell, DI; Macpherson, JS; Smyth, JF | 1 |
Pai, R; Tarnawski, AS; Tran, T | 1 |
Argov, S; Bernshtain, E; Goldstein, J; Mordechai, S; Sahu, RK; Salman, A; Walfisch, S | 1 |
Kohno, H; Sugie, S; Suzuki, R; Tanaka, T | 3 |
De Bruyne, G; Lauwaet, T; Leroy, A; Mareel, M; Oliveira, MJ | 1 |
Alaimo, G; Alessandro, R; Corrado, C; De Leo, A; De Leo, G; Flugy, AM; Russo, D; Stassi, G | 1 |
Chen, A; Xu, J | 1 |
Isoe, T; Kamishohara, M; Kubo, K; Miura, T; Nakamura, K; Shibuya, M; Taguchi, E; Takahashi, K; Yamamoto, A | 1 |
Bertagnolli, MM; Carothers, AM; Moran, AE; Redston, M; Weyant, MJ | 1 |
Avizienyte, E; Brunton, VG; Fincham, VJ; Frame, MC; Metcalf, CA; Sawyer, TK; Serrels, B | 1 |
Bang, MH; Cho, HJ; Jung, KC; Kang, NE; Kim, ES; Kim, WK; Park, JH | 1 |
Kucuk, O; Majumdar, AP; Marciniak, D; Rishi, AK; Sarkar, FH; Xu, H; Yu, Y | 1 |
Cramer, T; Herzig, KH; Höcker, M; Mergler, S; Müerköster, S; Schäfer, H; Schmidt, WE; Schmitz, F; Yu, HG | 1 |
Ding, J; Li, D; Luo, HS; Yu, HG; Yu, JP | 1 |
Besselsen, DG; Blohm-Mangone, KA; Cui, H; Gerner, EW; Holubec, H; Ignatenko, NA; Padilla-Torres, JL; Payne, CM; Stringer, DE; Yerushalmi, HF | 1 |
Debnam, ES; Kuhnle, GG; Lee, SY; Munerol, B; Pannala, AS; Pollard, S; Rice-Evans, C; Spencer, JP; Youdim, KA | 1 |
Beales, IL; Ogunwobi, O | 1 |
Brattain, MG; Cookson, MM; Hauser, J; Omar, Y; Sawhney, RS | 1 |
Herz, M; Schwaiger, M; Seidl, C; Senekowitsch-Schmidtke, R; Stöber, B; Tanase, U | 1 |
Bachi, A; Barilà, D; Bonifazi, AP; Condò, I; Coppola, L; Cursi, S; Matafora, V; Rufini, A; Stagni, V; Superti-Furga, G; Testi, R | 1 |
Andoh, R; Fukui, Y; Ihara, S; Kobayashi, M; Konishi, H; Nashimoto, T; Shi, BH; Xu, Q | 1 |
Ding, J; Ding, YM; Fang, XM; Liu, QS; Liu, ZJ; Luo, HS; Tong, SL; Yu, HG; Yu, JP; Zhang, XF; Zhou, YH | 1 |
Levi, E; Majumdar, AP; Reddy, S; Rishi, AK; Sarkar, FH; Xu, H | 1 |
Fukuyama, N; Ishiwata, K; Ito, I; Jujo, S; Mori, H; Myojin, K; Nagano, M; Nakazawa, H; Shizuma, T | 1 |
Ezaki, T; Guo, RJ; Li, H; Lynch, JP; Reynolds, AB | 1 |
Kohno, H; Miyamoto, S; Sugie, S; Suzuki, R; Tanaka, T; Tsukamoto, T; Yasui, Y | 1 |
Buricchi, F; Chiarugi, P; Fernandez-Checa, JC; Lluis, JM; Morales, A | 1 |
Cao, J; Luo, HS; Song, WC; Yu, HG; Yu, JP; Zhou, L | 1 |
Chao, HP; Fu, SL; Kuo, CD; Liang, FP; Lin, CH | 1 |
Gerner, EW; Kachel, KL; Rial, NS; Roy, UK | 1 |
Basson, MD; Craig, DH; Downey, C | 1 |
Grossman, H; Kirks, DR; Merten, DF | 1 |
Martinez, R; Nakamura, KD; Weber, MJ | 1 |
Hill, MJ; Thompson, MH | 1 |
Gmeiner, BM; Seelos, CC | 1 |
Heruth, DP; Leyva, A; Rothberg, PG; Wetmore, LA | 1 |
Ducker, TP; Goueli, SA; Skubitz, AP; Skubitz, KM | 1 |
Greathead, P; Pories, SE; Simpson, H; Steele, G; Summerhayes, IC; Weber, TK | 1 |
Tsuruo, T; Yamori, T | 1 |
Baldwin, GS; Burgess, AW; Ji, H; Moritz, RL; Simpson, RJ; Ward, LD | 1 |
Capolongo, L; Ciomei, M; Geroni, C; Grandi, M; Melegaro, G; Pastori, W; Pennella, G | 1 |
Kim, YS; Lamprecht, SA; Niv, Y; Polak-Charcon, S; Schwartz, B | 1 |
Murata, T; Noguchi, PD; Puri, RK | 1 |
Cummings, J; Macpherson, JS; Meikle, I; Smyth, JF | 2 |
Beauchemin, N; Chow, B; Daniels, E; Kunath, T; Robitaille, J; Turbide, C; Veillette, A | 1 |
Ambs, S; Bennett, WP; Billiar, TR; Felley-Bosco, E; Harris, CC; Klein, S; Merriam, WG; Ogunfusika, MO; Oser, SM; Shields, PG | 1 |
Hioki, K; Kameshita, I; Mohri, T; Suzuki, S; Takatani, S; Tokunaga, R | 1 |
Heiss, P; Herz, M; Schwaiger, M; Senekowitsch-Schmidtke, R; Stöcklin, G; Weber, W; Wester, HJ | 1 |
Kojima, M; Matsunari, Y; Mibu, R; Morisaki, T; Tanaka, M; Tsukahara, Y; Uchiyama, A | 1 |
Bernstein, C; Bernstein, H; Hoglen, N; Payne, CM; Washo-Stultz, D | 1 |
Czerucka, D; Dahan, S; Mograbi, B; Rampal, P; Rossi, B | 1 |
Akaike, T; Hayashida, K; Maeda, H; Okamoto, T; Okuyama, A; Wu, J | 1 |
Kim, K; Lee, KY | 1 |
Chrétien, M; Khatib, AM; Luis, J; Metrakos, P; Prat, A; Seidah, NG; Siegfried, G | 1 |
Bamberger, AM; Brümmer, J; Ebrahimnejad, A; Flayeh, R; Löning, T; Schumacher, U; Wagener, C | 1 |
Chuang, Y; Chung, DC; Kirley, SD; Wu, CL; Xiao, H; Zukerberg, LR | 1 |
Boyd, G; Burchell, B; Cummings, J; Ethell, BT; Jodrell, DI; Macpherson, JS; Smyth, JF | 1 |
Barrows, LR; Copp, BR; Ireland, CM | 1 |
Kamer, AR; Lee, MT; Liebow, C; Schally, AV | 1 |
Iizuka, Y; Iwashita, S; Nishiya, S; Takatori, T; Takayama, Y; Tsuruo, T; Yamazaki, A; Yamori, T | 1 |
Chu, SH; Walker, WA | 1 |
Bolen, JB; DeSeau, V; Rosen, N | 1 |
Cartwright, CA; Eckhart, W; Kamps, MP; Meisler, AI; Pipas, JM | 1 |
Gilchrest, BA; Gordon, PR; Kaplan, MM; Lee, JK; Stall, GM | 1 |
Friedman, E; Marian, B; Winawer, S | 1 |
Holm, E; Leweling, H; Ritz, R; Saeger, HD; Striebel, JP | 1 |
1 review(s) available for tyrosine and Colonic Neoplasms
Article | Year |
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Congenital and inheritable diseases associated with tumors and generalized malignancies--an imaging approach.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Basal Cell Nevus Syndrome; Beckwith-Wiedemann Syndrome; Child; Child, Preschool; Chondroma; Colonic Neoplasms; Down Syndrome; Female; Humans; Intestinal Polyps; Iris; Male; Multiple Endocrine Neoplasia; Neoplasms; Neurofibromatosis 1; Nevus, Pigmented; Tuberous Sclerosis; Tyrosine; von Hippel-Lindau Disease | 1983 |
104 other study(ies) available for tyrosine and Colonic Neoplasms
Article | Year |
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JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function.
Topics: Adenocarcinoma; Antineoplastic Agents; Benzoxazoles; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Time Factors; Tyrosine | 2020 |
Gangliosides and CD82 inhibit the motility of colon cancer by downregulating the phosphorylation of EGFR at different tyrosine sites and signaling pathways.
Topics: Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Down-Regulation; ErbB Receptors; G(M2) Ganglioside; G(M3) Ganglioside; Humans; Kangai-1 Protein; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Signal Transduction; Transfection; Tyrosine | 2020 |
Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.
Topics: Animals; Carcinogenesis; Cell Proliferation; Colitis; Colonic Neoplasms; Cytokines; Female; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Receptors, Interleukin; STAT3 Transcription Factor; Transcriptome; Tyrosine | 2021 |
Different Response Profiles of Gastrointestinal Cancer Cells to an L-Type Amino Acid Transporter Inhibitor, JPH203.
Topics: Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Tyrosine | 2019 |
Tyrosine 51 residue of the syndecan-2 extracellular domain is involved in the interaction with and activation of pro-matrix metalloproteinase-7.
Topics: Adenocarcinoma; Carcinogenesis; Cell Membrane; Colonic Neoplasms; Enzyme Activation; Extracellular Matrix; HT29 Cells; Humans; Magnetic Resonance Spectroscopy; Matrix Metalloproteinase 7; Molecular Docking Simulation; Mutagenesis; Protein Conformation, alpha-Helical; Protein Domains; Signal Transduction; Syndecan-2; Transfection; Tyrosine | 2019 |
X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis.
Topics: Binding Sites; Blotting, Western; Cell Adhesion; Cell Proliferation; Colonic Neoplasms; Cyclin D1; G1 Phase; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mutation; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; S Phase; Transcription Factor AP-1; Tyrosine; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein | 2013 |
Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells.
Topics: Cell Line, Tumor; Cell Membrane; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Metalloproteases; Phosphatidylinositol 3-Kinases; Receptors, Prostaglandin E, EP4 Subtype; Transcriptional Activation; Tyrosine | 2013 |
PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity.
Topics: Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Epithelial Cells; Humans; Mutation; p120 GTPase Activating Protein; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 12; rho GTP-Binding Proteins; Tyrosine | 2014 |
Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.
Topics: Cell Line, Tumor; Colonic Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Paxillin; Phosphorylation; Receptor, Cholecystokinin B; Rho Guanine Nucleotide Exchange Factors; Tyrosine | 2015 |
Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.
Topics: Breast Neoplasms; Colonic Neoplasms; Female; GRB2 Adaptor Protein; HEK293 Cells; Humans; Male; MAP Kinase Signaling System; Phosphorylation; Prostatic Neoplasms; Protein Multimerization; Signal Transduction; Son of Sevenless Proteins; src Homology Domains; Tissue Array Analysis; Tyrosine | 2015 |
Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Caco-2 Cells; Colonic Neoplasms; ErbB Receptors; Female; HT29 Cells; Humans; Lysosomes; Mice, Nude; Olive Oil; Phenylethyl Alcohol; Phosphorylation; Proteasome Endopeptidase Complex; Tyrosine; Xenograft Model Antitumor Assays | 2016 |
Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Colon; Colonic Neoplasms; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Stability; src-Family Kinases; Transplantation, Heterologous; Tyrosine | 2016 |
Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Activation; Fibroblasts; Humans; Mutant Proteins; Mutation; Phosphorylation; Protein Isoforms; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Receptor, IGF Type 1; Signal Transduction; src-Family Kinases; Thyroid Neoplasms; Tumor Stem Cell Assay; Tyrosine | 2016 |
Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells.
Topics: beta-Cyclodextrins; Blotting, Western; Caveolae; Cell Adhesion; Cholesterol; Colonic Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoprecipitation; Integrins; Membrane Microdomains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fyn; Signal Transduction; src-Family Kinases; Transfection; Tumor Cells, Cultured; Tyrosine | 2008 |
A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice.
Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Tocopherol; Inflammation; Leukotriene B4; Male; Mice; Tyrosine | 2009 |
Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell line.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Base Sequence; Colonic Neoplasms; DNA Primers; Down-Regulation; Female; HT29 Cells; Humans; Immunohistochemistry; In Vitro Techniques; Interleukin-6; Macrophages; Male; Middle Aged; Mucin-1; Mucin-2; Phosphorylation; Recombinant Proteins; STAT3 Transcription Factor; Tyrosine; Up-Regulation | 2009 |
Methylamine dichloramine may play a role in the process of colorectal disease through architectural and oxidative changes in crypts in mice.
Topics: Aldehydes; Animals; Chloramines; Colon; Colonic Neoplasms; Hemoglobins; Hemolysis; Hydrogen Peroxide; Hypochlorous Acid; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Neutrophil Activation; Oxidation-Reduction; Sheep; Tyrosine | 2009 |
Orexins/hypocretins and orexin receptors in apoptosis: a mini-review.
Topics: Amino Acid Motifs; Animals; Apoptosis; Brain; Colonic Neoplasms; Cytochromes c; Humans; Mitochondria; Neurons; Orexin Receptors; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Tyrosine | 2010 |
The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of beta-1,6-GlcNAc branching on HUVEC conformation.
Topics: Acetylglucosamine; Actin Cytoskeleton; Carbohydrate Conformation; Cell Shape; Cell Survival; Colonic Neoplasms; Culture Media, Conditioned; Cytoskeleton; Endothelial Cells; Enzyme Activation; Flow Cytometry; Glycosylation; HT29 Cells; Humans; Intercellular Junctions; Neoplasm Invasiveness; Permeability; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Polysaccharides; Protein Processing, Post-Translational; rhoA GTP-Binding Protein; Stress Fibers; Time Factors; Tyrosine | 2010 |
Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action.
Topics: Animals; Aspirin; beta Catenin; Colonic Neoplasms; Electrophoretic Mobility Shift Assay; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Nude; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Tyrosine; Xenograft Model Antitumor Assays | 2011 |
Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2.
Topics: Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dioxoles; Gene Silencing; HT29 Cells; Humans; Lignans; Phosphorylation; Receptor, EphA1; Receptor, EphB2; Tyrosine | 2011 |
Preparation and biological evaluation of 3-[(76)Br]bromo-α-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors.
Topics: Adenocarcinoma; Animals; Biological Transport; Cell Line, Tumor; Colonic Neoplasms; Drug Design; Drug Stability; Humans; Male; Mice; Positron-Emission Tomography; Tyrosine | 2011 |
Cat's whiskers tea (Orthosiphon stamineus) extract inhibits growth of colon tumor in nude mice and angiogenesis in endothelial cells via suppressing VEGFR phosphorylation.
Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Cell Proliferation; Chromatography, High Pressure Liquid; Colonic Neoplasms; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Nude; Orthosiphon; Phosphorylation; Plant Extracts; Plants, Medicinal; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2012 |
δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats.
Topics: Aldehydes; alpha-Tocopherol; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Cyclin D1; Dinoprost; Dinoprostone; gamma-Tocopherol; Immunohistochemistry; Male; Models, Chemical; Rats; Rats, Inbred F344; Tocopherols; Tyrosine | 2012 |
The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans.
Topics: Colitis; Colonic Neoplasms; HT29 Cells; Humans; Immunohistochemistry; NF-kappa B; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; Tumor Cells, Cultured; Tyrosine | 2012 |
Thermostable direct hemolysin diminishes tyrosine phosphorylation of epidermal growth factor receptor through protein kinase C dependent mechanism.
Topics: Bacterial Toxins; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Enterotoxins; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Hemolysin Proteins; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C-alpha; RNA, Small Interfering; Signal Transduction; Tyrosine | 2012 |
Antitumoral and mechanistic studies of ianthelline isolated from the Arctic sponge Stryphnus fortis.
Topics: Animals; Antineoplastic Agents; Biological Products; Breast Neoplasms; Carcinoma; Cell Division; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Humans; Imidazoles; Leukemia; Melanoma; Porifera; Protein Kinase Inhibitors; Sea Urchins; Spindle Apparatus; Tyrosine | 2012 |
STAT1 is required for IFN-gamma-mediated gut-enriched Krüppel-like factor expression.
Topics: Base Sequence; Blotting, Northern; Blotting, Western; Colonic Neoplasms; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Gene Expression; Humans; Interferon Regulatory Factor-1; Interferon-gamma; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Luciferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2002 |
Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Case-Control Studies; Colonic Neoplasms; Cysteine; Feeding Behavior; Female; Hemochromatosis Protein; Heterozygote; Histidine; Histocompatibility Antigens Class I; Humans; Iron Compounds; Male; Meat; Membrane Proteins; Middle Aged; Mutation; North Carolina; Risk Assessment; Risk Factors; Tyrosine | 2003 |
Role of calcium in E-selectin induced phenotype of T84 colon carcinoma cells.
Topics: Antineoplastic Agents; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Movement; Colonic Neoplasms; E-Selectin; Humans; Imidazoles; Phenotype; Phosphorylation; Recombinant Proteins; Triazoles; Tumor Cells, Cultured; Tyrosine | 2003 |
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Binding Sites; CHO Cells; Colonic Neoplasms; Cricetinae; Furin; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mutagenesis, Site-Directed; Phosphorylation; Platelet-Derived Growth Factor; Polymerase Chain Reaction; Proprotein Convertase 5; Proprotein Convertases; Protein Precursors; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Subtilisins; Transfection; Tumor Cells, Cultured; Tyrosine | 2003 |
Different phenotypes of colon carcinoma cells interacting with endothelial cells: role of E-selectin and ultrastructural data.
Topics: Actins; Carcinoma; Cell Adhesion; Cell Line, Tumor; Cell Size; Colonic Neoplasms; Cytoskeleton; E-Selectin; Endothelium, Vascular; Humans; Phenotype; Tyrosine | 2003 |
Expression of GRP and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407.
Topics: Algorithms; Cell Differentiation; Colonic Neoplasms; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gastrin-Releasing Peptide; Humans; Immunohistochemistry; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Bombesin; Tyrosine | 2003 |
New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Central Nervous System Neoplasms; Colonic Neoplasms; Disulfides; Drug Screening Assays, Antitumor; Electron Spin Resonance Spectroscopy; Female; Humans; Korea; Lung Neoplasms; Methicillin Resistance; Microbial Sensitivity Tests; Ofloxacin; Ovarian Neoplasms; Porifera; Skin Neoplasms; Staphylococcus; Tumor Cells, Cultured; Tyrosine | 2003 |
Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.
Topics: Anthraquinones; Antigens, CD; Antineoplastic Agents, Phytogenic; Biological Transport; Camptothecin; Carrier Proteins; Colonic Neoplasms; Drug Interactions; Drug Resistance; Glucuronides; HT29 Cells; Humans; Irinotecan; Membrane Glycoproteins; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Tetraspanin 29; Tumor Cells, Cultured; Tyrosine | 2004 |
Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells.
Topics: Colonic Neoplasms; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Densitometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Humans; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptor, Cholecystokinin B; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured; Tyrosine | 2004 |
Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives.
Topics: Anthraquinones; Biopsy; Camptothecin; Catalysis; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Food Additives; Glucuronides; Glucuronosyltransferase; Humans; Irinotecan; Isoenzymes; Propofol; Topoisomerase I Inhibitors; Tyrosine | 2003 |
Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness.
Topics: beta Catenin; Biological Assay; Cadherins; Cell Line; Colonic Neoplasms; Cyclin D1; Cytoskeletal Proteins; Deoxycholic Acid; Gene Expression Regulation; Humans; Neoplasm Invasiveness; Phosphorylation; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Small Interfering; Signal Transduction; Trans-Activators; Tyrosine; Urokinase-Type Plasminogen Activator | 2004 |
Detection of abnormal proliferation in histologically 'normal' colonic biopsies using FTIR-microspectroscopy.
Topics: Cell Division; Cell Movement; Colon; Colonic Neoplasms; DNA; Feasibility Studies; Humans; RNA; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2004 |
Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Immunoenzyme Techniques; Incidence; Injections, Intraperitoneal; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Precancerous Conditions; Tyrosine | 2004 |
Listeria monocytogenes produces a pro-invasive factor that signals via ErbB2/ErbB3 heterodimers.
Topics: Blotting, Western; Cell Line, Tumor; Collagen Type I; Colonic Neoplasms; Humans; Immunoprecipitation; Listeria monocytogenes; Listeriosis; Neoplasm Invasiveness; Phosphorylation; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Tyrosine | 2005 |
Identification and phenotypic characterization of a subpopulation of T84 human colon cancer cells, after selection on activated endothelial cells.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Communication; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Metalloproteases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phenotype; Phosphorylation; src-Family Kinases; Tyrosine; Umbilical Veins | 2005 |
Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Curcumin; Cyclin D1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Phosphorylation; Plasmids; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transfection; Tyrosine | 2005 |
KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth.
Topics: Angiogenesis Inhibitors; Animals; Cell Proliferation; Colonic Neoplasms; Endothelial Cells; Enzyme Activation; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Phosphorylation; Prostatic Neoplasms; Quinazolines; Rats; Rats, Nude; Transplantation, Heterologous; Tyrosine; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse.
Topics: Abietanes; Adenoma; Animals; beta Catenin; Cadherins; Cell Adhesion; Cell Membrane; Colonic Neoplasms; Cytoskeletal Proteins; Enterocytes; Female; Intestine, Small; Mice; Mice, Inbred C57BL; Phenanthrenes; Phosphorylation; Rosmarinus; Trans-Activators; Tyrosine; Vanadates | 2005 |
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior.
Topics: Animals; Binding Sites; Catalysis; Cell Adhesion; Cell Movement; Colonic Neoplasms; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice; Mice, Nude; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; src Homology Domains; src-Family Kinases; Substrate Specificity; Tyrosine | 2005 |
Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane.
Topics: Animals; Azoxymethane; Carcinogens; Cocarcinogenesis; Colitis; Colonic Diseases; Colonic Neoplasms; Dextran Sulfate; Dose-Response Relationship, Drug; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Tyrosine; Ulcer | 2005 |
Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells.
Topics: Apoptosis; Cell Division; Colonic Neoplasms; DNA Fragmentation; Gene Expression; Genes, erbB; Genes, erbB-2; Humans; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quercetin; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2005 |
Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Cetuximab; Colonic Neoplasms; Dose-Response Relationship, Drug; ErbB Receptors; Glycoproteins; Humans; Ligands; Mice; Neuregulin-1; NIH 3T3 Cells; Phosphorylation; Rats; Receptor, ErbB-2; Recombinant Fusion Proteins; Trastuzumab; Tyrosine | 2005 |
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bezafibrate; Body Weight; Chromans; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Hypolipidemic Agents; Immunohistochemistry; Inflammation; Injections, Intraperitoneal; Ligands; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Organ Size; Peroxisome Proliferator-Activated Receptors; Sulfonamides; Temperature; Thiazolidinediones; Troglitazone; Tyrosine; Vasodilator Agents | 2005 |
Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclic AMP; Focal Adhesion Kinase 1; Gastrins; Genes, Immediate-Early; Humans; Inositol 1,4,5-Trisphosphate; Paxillin; Phosphorylation; Point Mutation; Protein Structure, Secondary; Receptor, Cholecystokinin B; RNA, Messenger; Signal Transduction; Transfection; Tyrosine; Up-Regulation; Valine | 2005 |
[A study of gastrin-focal adhesion kinase signal pathway in human colon cancer cells].
Topics: Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Down-Regulation; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Humans; Phosphorylation; Receptor, Cholecystokinin B; RNA, Messenger; Signal Transduction; Tyrosine; Up-Regulation | 2005 |
The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Arginine; Colonic Neoplasms; Dietary Supplements; Female; Intestinal Neoplasms; Intestine, Small; Male; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tyrosine | 2006 |
The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth.
Topics: Absorption; Animals; Apoptosis; Caco-2 Cells; Caspase 3; Caspases; Catechin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flavonoids; Gastrointestinal Tract; Humans; In Vitro Techniques; Mitogen-Activated Protein Kinase Kinases; Nitrosamines; Nitroso Compounds; Nitrous Acid; Phenols; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Reactive Nitrogen Species; Time Factors; Tyrosine | 2006 |
Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.
Topics: Anthracenes; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Survival; Chromones; Colonic Neoplasms; Gastrins; Humans; Janus Kinase 2; JNK Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrazoles; Signal Transduction; STAT3 Transcription Factor; Sulfonamides; Transcription Factor AP-1; Tyrosine; Tyrphostins | 2006 |
Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway.
Topics: Biotinylation; Butadienes; Calpain; Cell Adhesion; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Cytochalasin D; Electric Impedance; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin alpha2; Mitogen-Activated Protein Kinases; Nitriles; Nucleic Acid Synthesis Inhibitors; Oligonucleotides, Antisense; Phosphorylation; Point Mutation; Precipitin Tests; Protein Structure, Tertiary; Signal Transduction; Substrate Specificity; Tyrosine | 2006 |
Differentiation of tumour and inflammation: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells.
Topics: Cells, Cultured; Colonic Neoplasms; Diagnosis, Differential; Fluorine Radioisotopes; Humans; Inflammation; Metabolic Clearance Rate; Methionine; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2006 |
Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.
Topics: Amino Acid Sequence; Apoptosis; Caspase 8; Caspases; Colonic Neoplasms; Enzyme Activation; ErbB Receptors; fas Receptor; Humans; Molecular Sequence Data; Mutation; Schizosaccharomyces; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 2006 |
Mutation of the PI3' kinase gene in a human colon carcinoma cell line, HCC2998.
Topics: Alleles; Base Sequence; Cell Differentiation; Cell Line, Tumor; Cloning, Molecular; Colonic Neoplasms; DNA Mutational Analysis; DNA, Neoplasm; Humans; Molecular Sequence Data; Molecular Weight; Mucins; Phosphatidylinositol 3-Kinases; Phosphorylation; Point Mutation; Protein Subunits; Receptor, ErbB-3; Tyrosine | 2006 |
Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase.
Topics: Benzodiazepinones; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Disease Progression; Enzyme Activation; Female; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Male; Middle Aged; Oligonucleotides, Antisense; Phenylurea Compounds; Phosphorylation; Receptor, Cholecystokinin B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tyrosine | 2006 |
Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Combined Modality Therapy; Curcuma; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glycoproteins; HCT116 Cells; HT29 Cells; Humans; NF-kappa B; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine | 2006 |
Kurozu moromimatsu inhibits tumor growth of Lovo cells in a mouse model in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Female; Fermentation; Metalloproteases; Mice; Mice, Nude; Neoplasm Transplantation; Oryza; Phytotherapy; Plant Extracts; Random Allocation; Specific Pathogen-Free Organisms; Tyrosine | 2007 |
The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation.
Topics: Animals; beta Catenin; Cadherins; Catenins; CDX2 Transcription Factor; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Delta Catenin; Homeodomain Proteins; Humans; Mice; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Transcription Factors; Transfection; Tyrosine | 2007 |
A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis.
Topics: Animals; Body Weight; Cholesterol; Colonic Neoplasms; DNA, Single-Stranded; Immunohistochemistry; Inflammation; Male; Mice; Molecular Structure; Organ Size; Proliferating Cell Nuclear Antigen; Quinolines; Time Factors; Triglycerides; Tyrosine | 2007 |
Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Death; Cell Hypoxia; Colonic Neoplasms; Electrophoretic Mobility Shift Assay; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Liver Neoplasms; Mitochondria; Mutagenesis, Site-Directed; Neuroblastoma; NF-kappa B; Oxidants; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine | 2007 |
[Molecular mechanism of gastrin increasing colon cancer cells' invasion].
Topics: Benzodiazepinones; Blotting, Western; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Humans; Neoplasm Invasiveness; Phenylurea Compounds; Phosphorylation; Receptor, Cholecystokinin B; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tyrosine | 2007 |
Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.
Topics: Antiviral Agents; Butadienes; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Diterpenes; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gene Expression Regulation, Neoplastic; Hot Temperature; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitriles; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Tyrosine; Ubiquitin; Ubiquitination | 2008 |
Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis.
Topics: Adaptor Proteins, Signal Transducing; Biological Transport; Blotting, Western; Calcium-Binding Proteins; Caveolae; Caveolin 1; Cell Membrane; Colonic Neoplasms; Dynamins; Endocytosis; Genes, ras; Humans; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Phosphoproteins; Phosphorylation; Polyamines; Tumor Cells, Cultured; Tyrosine | 2008 |
Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1.
Topics: Actinin; Cell Adhesion; Cell Line, Tumor; Colonic Neoplasms; Crk-Associated Substrate Protein; Humans; Neoplasm Metastasis; Paxillin; Phosphorylation; Pressure; Proto-Oncogene Proteins c-crk; rac1 GTP-Binding Protein; RNA Interference; Tumor Cells, Cultured; Tyrosine | 2008 |
Cultured cells transformed by Rous sarcoma virus: a genetically defined model and its phenotype.
Topics: Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Models, Biological; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Tyrosine | 1983 |
Some etiological factors in large-bowel cancer.
Topics: Adenoma; Bile Acids and Salts; Colonic Neoplasms; Environment; Fatty Acids, Unsaturated; Humans; Nitrosamines; Steroids; Tryptophan; Tyrosine | 1982 |
Measurement of phosphotyrosine phosphatase activity using the Folin-Ciocalteu phenol reaction.
Topics: Amino Acid Sequence; Animals; Carcinoma; Colonic Neoplasms; Indicators and Reagents; Liver; Molecular Sequence Data; Molybdenum; Protein Tyrosine Phosphatases; Rats; Sensitivity and Specificity; Tumor Cells, Cultured; Tungsten Compounds; Tyrosine | 1995 |
Influence of protein tyrosine phosphorylation on the expression of the c-myc oncogene in cancer of the large bowel.
Topics: Benzoquinones; Cell Count; Cell Line; Colonic Neoplasms; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, myc; Genistein; Half-Life; Humans; Isoflavones; Lactams, Macrocyclic; Novobiocin; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinones; RNA, Messenger; Topoisomerase II Inhibitors; Tyrosine; Vanadates | 1995 |
Antiserum to carcinoembryonic antigen recognizes a phosphotyrosine-containing protein in human colon cancer cell lines.
Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Humans; In Vitro Techniques; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Tumor Cells, Cultured; Tyrosine | 1993 |
Immortalization and neoplastic transformation of normal rat colon epithelium: an in vitro model of colonic neoplastic progression.
Topics: Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cytological Techniques; Gene Expression; Intestinal Mucosa; Phosphotyrosine; Rats; Reference Values; Simian virus 40; Tyrosine | 1993 |
[Signal transduction of insulin-like growth factor I in a highly metastatic tumor cell line].
Topics: Animals; Colonic Neoplasms; Insulin-Like Growth Factor I; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1993 |
Epidermal growth factor induces serine phosphorylation of stathmin in a human colon carcinoma cell line (LIM 1215).
Topics: Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; Microtubule Proteins; Molecular Sequence Data; Oligonucleotides, Antisense; Peptide Mapping; Phosphoproteins; Phosphorylation; Serine; Stathmin; Tumor Cells, Cultured; Tyrosine | 1993 |
Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Distamycins; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Humans; Leukemia L1210; Mice; Neoplasm Proteins; Nitrogen Mustard Compounds; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sensitivity and Specificity; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaline Phosphatase; Benzylidene Compounds; Cell Differentiation; Cell Line; Colonic Neoplasms; Colorectal Neoplasms; Cytosol; Enzyme Inhibitors; Humans; Kinetics; Microscopy, Electron, Scanning; Nitriles; Phenols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1995 |
IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
Topics: Antigens, CD; B-Lymphocytes; Cell Line, Transformed; Colonic Neoplasms; Enzyme Activation; Humans; Interleukin-13; Interleukin-4; Janus Kinase 1; Janus Kinase 2; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptor, Insulin; Receptors, Interleukin; Receptors, Interleukin-4; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; TYK2 Kinase; Tyrosine | 1996 |
Characterization of the major metabolite of the novel topoisomerase I inhibitor NU/ICRF 505.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Biotransformation; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Liver; Lung Neoplasms; Mice; Mice, Nude; Molecular Structure; Ovarian Neoplasms; Spectrometry, Mass, Fast Atom Bombardment; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tyrosine | 1996 |
Determination of the novel topoisomerase I inhibitor NU/ICRF 505 and its major metabolite in plasma, tissue and tumour by high-performance liquid chromatography.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Reference Standards; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tyrosine | 1996 |
Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells.
Topics: Amino Acid Sequence; Animals; Carcinoembryonic Antigen; Cell Adhesion Molecules; Colonic Neoplasms; Glycoproteins; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tumor Cells, Cultured; Tyrosine; Vanadates | 1997 |
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.
Topics: Adenoma; Blotting, Western; Carcinoma; Colon; Colonic Neoplasms; Disease Progression; DNA Primers; DNA, Neoplasm; Endothelial Growth Factors; Endothelium, Vascular; Humans; Immunohistochemistry; Lymphokines; Neoplasm Proteins; Neovascularization, Pathologic; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Polymerase Chain Reaction; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A.
Topics: Adenocarcinoma; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; Cyclosporine; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosuppressive Agents; Indole Alkaloids; Indoles; Integrins; Neoplasm Metastasis; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Sulfonamides; Tacrolimus; Tumor Cells, Cultured; Tyrosine | 1998 |
Synthesis and radiopharmacology of O-(2-[18F]fluoroethyl)-L-tyrosine for tumor imaging.
Topics: Animals; Astrocytoma; Brain Neoplasms; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Humans; Male; Mammary Neoplasms, Experimental; Mice; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Transplantation; Tissue Distribution; Tomography, Emission-Computed; Transplantation, Heterologous; Tyrosine | 1999 |
Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sigmoid Neoplasms; Tyrosine | 1999 |
Role of nitric oxide and peroxynitrite in bile salt-induced apoptosis: relevance to colon carcinogenesis.
Topics: Apoptosis; Bile Acids and Salts; Colonic Neoplasms; Deoxycholic Acid; Enzyme Inhibitors; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Salicylates; Superoxides; Tumor Cells, Cultured; Tyrosine | 1999 |
Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Membrane Permeability; Colonic Neoplasms; Electric Impedance; Enzyme Activation; Escherichia coli; Humans; Intestinal Mucosa; Inulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Saccharomyces; Signal Transduction; Tight Junctions; Tumor Cells, Cultured; Tyrosine | 2000 |
Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.
Topics: Adenocarcinoma; Animals; Azoles; Bradykinin; Capillary Permeability; Collagenases; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Precursors; Free Radical Scavengers; Gelatinases; Guinea Pigs; Isoindoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Nitrates; Oligopeptides; Organoselenium Compounds; Protease Inhibitors; Sarcoma 180; Skin; Tyrosine; Uric Acid | 2001 |
Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function.
Topics: 3T3 Cells; Animals; beta Catenin; Biological Transport; Cell Communication; Cell Membrane; Colonic Neoplasms; Cyclin D1; Cytoplasm; Cytoskeletal Proteins; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Humans; Luciferases; Lymphoid Enhancer-Binding Factor 1; Mice; Phosphorylation; Protein Tyrosine Phosphatases; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tyrosine; Vanadates | 2001 |
Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.
Topics: alpha 1-Antitrypsin; Animals; Apoptosis; Colonic Neoplasms; HT29 Cells; Humans; Immunohistochemistry; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Male; Mice; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Protein Precursors; Receptor, IGF Type 1; Tyrosine | 2001 |
cis Interaction of the cell adhesion molecule CEACAM1 with integrin beta(3).
Topics: Antigens, CD; Antigens, Differentiation; Binding Sites; Cell Adhesion Molecules; Chromatography, Affinity; Colonic Neoplasms; Endometrium; Female; Granulocytes; Humans; Integrin beta3; Melanoma; Microscopy, Confocal; Phosphorylation; Platelet Membrane Glycoproteins; Pregnancy; Pregnancy Trimester, First; Tumor Cells, Cultured; Tyrosine | 2001 |
Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.
Topics: Animals; Carcinoma, Squamous Cell; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle Proteins; Chromosomes, Human, Pair 18; Colonic Neoplasms; COS Cells; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; DNA, Complementary; Growth Inhibitors; Head and Neck Neoplasms; HeLa Cells; Humans; In Situ Hybridization, Fluorescence; Mice; Nuclear Proteins; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Transfection; Tyrosine | 2001 |
Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation.
Topics: Anthraquinones; Camptothecin; Colonic Neoplasms; Enzyme Inhibitors; Glucuronates; Glucuronides; HT29 Cells; Humans; Irinotecan; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolic Clearance Rate; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tyrosine | 2002 |
Psammaplysin C: a new cytotoxic dibromotyrosine-derived metabolite from the marine sponge Druinella (= Psammaplysilla) purpurea.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Porifera; Spiro Compounds; Tumor Cells, Cultured; Tyrosine | 1992 |
Effects of epidermal growth factor and analogues of luteinizing hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Autoradiography; Breast Neoplasms; Cell Line; Colonic Neoplasms; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Humans; Kinetics; Lung Neoplasms; Membrane Proteins; Molecular Sequence Data; Pancreatic Neoplasms; Phosphorus Radioisotopes; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Somatostatin; Triptorelin Pamoate; Tyrosine | 1991 |
Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon carcinoma 26 NL-17 cells.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Colonic Neoplasms; Epidermal Growth Factor; Insulin; Insulin-Like Growth Factor I; Kinetics; Mice; Molecular Weight; Neoplasm Metastasis; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Somatomedin; Sepharose; Tyrosine | 1991 |
Growth factor signal transduction in human intestinal cells.
Topics: Carcinoma; Colonic Neoplasms; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Kinetics; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Analysis of pp60c-src tyrosine kinase activity and phosphotyrosyl phosphatase activity in human colon carcinoma and normal human colon mucosal cells.
Topics: Adenocarcinoma; Buffers; Cells, Cultured; Colonic Neoplasms; Humans; Immunologic Techniques; Intestinal Mucosa; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine; Vanadates | 1987 |
pp60c-src activation in human colon carcinoma.
Topics: Carcinoma; Cell Line; Colonic Neoplasms; Enzyme Activation; Humans; Intestinal Mucosa; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Retroviridae Proteins; Tumor Cells, Cultured; Tyrosine | 1989 |
Phenolic and tyrosyl ring iodothyronine deiodination by the Caco-2 human colon carcinoma cell line.
Topics: Carcinoma; Cell Differentiation; Colonic Neoplasms; Humans; Intestinal Absorption; Iodine; Kinetics; Phenols; Thyroid Hormones; Thyroxine; Triiodothyronine; Tumor Cells, Cultured; Tyrosine | 1989 |
Tyrosine phosphorylation of a Mr 63,000 protein induced by an endogenous mitogen in human colon carcinoma cells, but not in normal colonocytes.
Topics: Carcinoma; Colon; Colonic Neoplasms; Diglycerides; Glycerides; Humans; Membrane Proteins; Mitogens; Molecular Weight; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
[Amino acid uptake and release by colorectal cancer in man].
Topics: Aged; Amino Acids; Colonic Neoplasms; Female; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Ornithine; Rectal Neoplasms; Tyrosine | 1986 |