tyrosine and Cell Transformation, Neoplastic

tyrosine has been researched along with Cell Transformation, Neoplastic in 396 studies

Research

Studies (396)

Timeframe	Studies, this research(%)	All Research%
pre-1990	74 (18.69)	18.7374
1990's	172 (43.43)	18.2507
2000's	101 (25.51)	29.6817
2010's	42 (10.61)	24.3611
2020's	7 (1.77)	2.80

Authors

Authors	Studies
Chen, PJ; Zhang, YT	1
Buolamwini, JK; Deokar, H; Pfeffer, LM; Raje, M; Sacher, JR; Sims, MM; Turkson, J; Wang, Y; Yang, C; Yue, P	1
Abbate, V; Floresta, G	1
Cao, J; Chen, J; Chen, L; Chen, S; Fan, G; Hao, P; Hou, L; Li, D; Wang, Y; Xiong, X; Zhang, J; Zhang, Y; Zhao, X; Zhu, Q; Zhuang, M	1
Ali, DW; Chen, XZ; Deng, X; Dong, X; Hu, M; Huang, H; Huang, Y; Li, S; Liu, N; Liu, S; Luo, S; Lyu, H; Michalak, M; Tang, J; Tang, Y; Wang, M; Wang, Z; Xiao, S; Zhang, R; Zhang, X; Zhou, C; Zhu, X	1
Chang, HW; Chang, VHS; Chien, LN; Chu, PG; Dong, F; Jia, W; Lin, IH; Liu, YR; Wu, MJ; Xie, G; Yang, YSH; Yen, Y	1
Abe, S; Kadonosono, T; Matsumura, M; Nakamura, H; Sato, S; Ueda, H; Ueno, T	1
Cao, X; Cong, YS; Dai, X; Feng, XH; Guo, X; Ji, X; Li, L; Liang, T; Si, Y; Tang, M; Xia, Z; Xu, L; Yan, H; Ye, S; Zhang, H; Zhao, B; Zhao, H; Zhou, Q; Zhu, C	1
Baltanas, FC; Cinquanta, M; Frittoli, E; Gerboth, S; Giuliani, C; Gomez, C; Illert, AL; Kreutmair, S; Minucci, S; Palamidessi, A; Pallavicini, I; Pruneri, G; Rappsilber, J; Rolland, Y; Salek, M; Santos, E; Scita, G; Troglio, F; Zobel, M	1
Grindheim, AK; Saraste, J; Vedeler, A	1
Honda, T; Morii, M; Nakayama, Y; Suzuki, K; Yamaguchi, N	1
Bashir, A; Brennum, J; Broholm, H; Law, I	1
Aoki, M; Hatazawa, J; Horitsugi, G; Ikeda, H; Kanai, Y; Kongpracha, P; Nagamori, S; Naka, S; Shimosegawa, E; Watabe, T	1
An, J; Bowden, M; Cetinbas, N; Chow, C; Gleave, M; Huang-Hobbs, H; Leprivier, G; McIntosh, LP; McKinney, S; Sorensen, PH; Tognon, C	1
Hellman, U; Kazi, JU; Lundby, A; Mohlin, S; Olsen, JV; Påhlman, S; Rönnstrand, L; Sun, J	1
Chang, PL; Guan, JL; Hsieh, YH; Oh, ES; van der Heyde, H	1
Agarwal, S; Kazi, JU; Mohlin, S; Påhlman, S; Rönnstrand, L	1
Broholm, H; El Ali, H; Kjaer, A; Lassen, U; Michaelsen, SR; Nedergaard, MK; Poulsen, HS; Stockhausen, MT; Urup, T	1
Bolland, S; Buchner, M; Chen, Z; Coligan, JE; Geng, H; Graeber, TG; Hunger, SP; Jumaa, H; Jung, JU; Klemm, L; Lee, JW; Limnander, A; Loh, ML; Lowell, CA; Mak, TW; Melnick, A; Müschen, M; Paietta, E; Park, E; Reth, M; Satterthwaite, A; Shojaee, S; Tan, YX; Titz, B; Weiss, A; Willman, CL	1
Anastasiadis, PZ; Copland, JA; Huveldt, D; Kourtidis, A; Yanagisawa, M	1
Yakovlev, VA	1
Dombrowski, F; Görlach, A; Jakupovic, M; Kietzmann, T; Konzack, A; Kubaichuk, K; Miinalainen, I; Sormunen, R	1
Erler, J; Kjaer, A; Lassen, U; Michaelsen, SR; Nedergaard, MK; Perryman, L; Poulsen, HS; Stockhausen, MT	1
Chen, J; Duan, Q; Fan, X; Shao, C; Sun, H; Wang, Z; Xiao, J; Xue, P; Yan, W; Zeng, X; Zhu, F	1
Huang, J; Mei, W; Wang, K; Zheng, X	1
Chougule, RA; Gazi, M; Kazi, JU; Li, T; Marhäll, A; Moharram, SA; Rönnstrand, L; Rupar, K; Su, X; Sun, J; Zhao, H	1
Buske, C; Hiddemann, W; Kern, R; Kohl, TM; Naidu, VM; Petropoulos, K; Reindl, C; Spiekermann, K; Vempati, S; Wolf, U	1
Chu, M; Deng, L; Fu, J; Huang, H; Liu, S; Wang, Y; Xu, L; Zhang, L; Zhang, X; Zhou, Z; Zhu, Y	1
Duhagon Serrat, MA; Farrar, WL; Hurt, EM; Kawasaki, BT; Kim, HJ; Kim, JY; Klarmann, GJ; Qin, HR	1
Durbin, JE; Koromilas, AE; Raven, JF; Wang, S	1
Bohgaki, M; Hatakeyama, S; Kameda, H; Tsukiyama, T; Watanabe, M	1
Hao, X; Ju, J; Lambert, JD; Lee, MJ; Lu, G; Newmark, HL; Xiao, H; Yang, CS	1
Follenzi, A; Locarno, D; Merlin, S; Pietronave, S; Prat, M; Valente, G	1
Elliott, BE; Foley, JH; Jia, Z; Li, JJ; Miller, F; Singh, VK; Wright, TG	1
Khan, R; Liu, T; Masson, K; Rönnstrand, L; Sun, J	1
Alvarado, D; Carpenter, G; Choi, SH; Lemmon, MA; Moravcevic, K; Pozzi, A; Red Brewer, M	1
Reich, NC	1
Lucs, AV; Muller, WJ; Muthuswamy, SK	1
Farago, M; Katzav, S; Lazer, G; Machida, K; Mayer, BJ; Pe'er, L	1
Dokmanovic, M; Hirsch, DS; Shen, Y; Wu, WJ	1
Berthois, Y; Calvo, F; Huet, E; Ma, L; Menashi, S; Mourah, S; Serova, M	1
Hatakeyama, M; Hayashi, T	1
Cheng, E; Huo, X; Souza, RF; Spechler, SJ; Wang, DH; Yu, C; Zhang, HY; Zhang, Q; Zhang, X	1
Funakoshi-Tago, M; Kamishimoto, J; Kasahara, T; Tago, K	1
Horiuchi, M; Izumo, K; Kawai, Y; Kawano, Y; Miyahara, E; Nishikawa, T; Okamoto, Y; Takeuchi, T	1
Brábek, J; Brůhová, Z; Hanks, SK; Janoštiak, R; Novotný, M; Rösel, D; Tolde, O	1
Fujii, R; Ichiba, M; Ishida-Kitagawa, N; Maruoka, M; Ogawa, T; Sato, M; Takeya, T; Watanabe, N; Yuan, Y	1
Anderhub, S; Bachmann, J; Bochtler, T; Ho, AD; Kirsch, M; Klingmüller, U; Krämer, A; Maier, B	1
Dalbay, M; Lim, SV; McDuff, FK; Turner, SD	1
Du, Y; Gao, S; Hu, M; Lubet, RA; Szabo, E; Wang, Y; Wen, W; Yao, R; You, M	1
Kapur, R; Ma, P; Mali, RS; Martin, H; Ramdas, B; Sims, E	1
Chen, JL; Chen, K; Druker, BJ; Guo, G; Kashiwada, M; Qiu, X; Rothman, PB	1
Bunting, KD; Chan, RJ; Chatterjee, A; Craig, AW; Feng, GS; Ghosh, J; He, Y; Kapur, R; Li, S; Ma, P; Mali, RS; Martin, H; Munugalavadla, V; Nabinger, S; Ramdas, B; Sandusky, G; Sharma, N; Sims, E; Zeng, LF; Zhang, ZY	1
Etoh, H; Kato, H; Maoka, T; Suzuki, N; Tokuda, H	1
Hutchison, RE; Mohi, G; Yan, D	1
Bergholz, U; Ding, LW; Gery, S; Gueller, S; Kazi, JU; Koeffler, HP; Koren-Michowitz, M; Lin, DC; Rönnstrand, L; Stocking, C; Tabayashi, T; Yin, T	1
Bene, J; Heerema, NA; Horton, S; Hosseini, SA; Huebner, K; Miuma, S; Saldivar, JC	1
Hiddemann, W; Janke, H; Polzer, H; Schmid, D; Spiekermann, K	1
Chen, D; Fu, J; Liu, C; Luo, L; Xin, Y; Xu, Y; Yin, Z; Zhao, B; Zhao, Z; Zhou, J	1
Feng, H; Fu, Y; Wu, H; Xiao, J; Zhou, M; Zhou, W	1
Kang, SA; Lee, ST	1
Gesbert, F; Griffin, JD; Gu, H; Iwasaki, H; Li, S; Malouf, NA; Mohi, MG; Neel, BG; Podar, K; Pride, YB; Quinnan, LR; Sattler, M; Van Etten, RA	1
Deal, C; Garnett, MJ; Morrison, KB; Sorensen, PH; Tognon, CE	1
Andrisani, OM; Hullinger, RL; Tarn, C; Zou, L	1
Gishizki, M; Greco, A; Miranda, C; Pierotti, MA; Ranzi, V; Roccato, E	1
Hashimoto, K; Ikeda, H; Kanakura, Y; Kim, DK; Kitamura, Y; Matsumura, I; Mizuki, M; Ogihara, H; Shibayama, H; Sugahara, H; Tsujimura, T; Ueda, S	1
Addicks, K; Bloch, W; Ehsan, A; Engelmann, U; Jacobs, G; Klotz, T; Koslowski, J; Niggemann, S; Schmidt, A; Sommer, F	1
Keating, M; Lai, R; Leventaki, V; McDonnell, TJ; Medeiros, LJ; Rassidakis, GZ	1
Briesewitz, R; Bruner, RJ; Caligiuri, MA; Griffin, JH; Leung, J	1
Bustelo, XR; Gutkind, JS; Marinissen, MJ; Servitja, JM; Sodhi, A	1
Smith, KM; Van Etten, RA; Yacobi, R	1
Ilan, N; Madri, JA; Tucker, A	1
Alexander, DB; Goldberg, GS; Miller, WT; Pellicena, P; Tsuda, H; Zhang, ZY	1
Christensen, JG; Chu, SC; Gramlich, JL; Liang, C; Ma, P; Podar, K; Pride, YB; Quinnan, LA; Salgia, R; Sattler, M; Shirazian, S	1
Gelman, IH; Moissoglu, K	1
Boerner, JL; Danielsen, AJ; Darce, JR; Faupel-Badger, JM; Juneja, SC; Lovejoy, CA; Maihle, NJ; Wang, Z	1
Jin, W; Kim, SJ; Lannon, CL; Martin, MJ; Sorensen, PH; Tognon, CE	1
Basolo, F; Castellone, MD; Celetti, A; Cirafici, AM; Curcio, F; Fusco, A; Giannini, R; Guarino, V; Kruhoffer, M; Medico, E; Melillo, RM; Orntoft, TF; Santoro, M	1
Arulanandam, R; Cao, J; Craig, A; Elliott, B; Greer, P; Jove, R; Raptis, L; Turkson, J; Vultur, A	1
Holgado-Madruga, M; Wong, AJ	1
Ishiyama, N; Lin, T; Lipkowitz, S; Park, M; Peschard, P	1
Bahk, YY; Han, I; Jeon, J; Lim, Y; Oh, ES; Park, H	1
Harakawa, N; Million, RP; Roumiantsev, S; Van Etten, RA; Varticovski, L	1
Ahn, B; Hahm, KB; Jang, DD; Kim, DY; Kim, YB; Nam, KT; Oh, SY; Yang, KH	1
Babendreier, E; Chauhan, D; Chu, SC; Gramlich, JL; Griffin, JD; Kim, JH; Podar, K; Pride, YB; Salgia, R; Sattler, M	1
Liu, SL; Miller, AD	1
Chen, J; Donoghue, DJ; Duclos, N; Gilliland, DG; Huntly, BJ; Lee, BH; Williams, IR	1
Gan, B; Guan, JL; Wu, X; Yoo, Y	1
Haegebarth, A; Nunez, R; Tyner, AL	1
Chang, LC; Chen, BH; Chen, HC; Cheng, CH; Huang, CH	1
Ichimatsu, D; Ito, H; Miyamoto, K; Nomura, M; Tsukada, H; Yoshida, T	1
Berger, DM; Birnberg, G; Boschelli, DH; Boschelli, F; Dutia, M; Golas, J; Lucas, J; Powell, D; Ravi, M; Wang, YD; Yaczko, D	1
Baserga, R; Chen, J; DeAngelis, T; Prisco, M; Wu, A	1
Dhanasekaran, N; Kumar, RN; Shore, SK	1
Meyer, RD; Mohammadi, M; Rahimi, N	1
Earp, HS; Mahajan, NP; Mohler, JL; Whang, YE	1
Chang, ZJ; Chen, XP; Chen, Y; Fu, XY; Gong, LM; Li, YH; Liu, L; Zhang, SP; Zhang, XF	1
Bernardini, MS; Crowley, JE; Grande, SM; Katz, E; Monroe, JG; Ross, SR	1
Harju, TH; Kinnula, VL; Pääkkö, PK; Puhakka, AR; Soini, YM	1
Grande, SM; Monroe, JG; Ross, SR	1
Giese, N; Gilliland, DG; Lee, BH; Okabe, R; Rocnik, JL; Schenkein, DP; Yu, JC	1
Agazie, YM; Burks, J	1
Lanier, LL	1
Abdi, FA; Engen, JR; Fahey, N; Hochrein, JM; Meyn, MA; Schiavone, AP; Smithgall, TE; Wilson, MB; Wu, J	1
Clarke, R; Decker, M; Liu, MC; Minshall, RD; Shajahan, AN; Wang, A	1
Aburatani, H; Akiyama, T; Azuma, T; Hatakeyama, M; Higashi, H; Kurashima, Y; Murata-Kamiya, N; Peek, RM; Saito, Y; Teishikata, Y; Yamahashi, Y	1
Kaldis, P	1
Arnaout, A; Chu, I; Hanna, W; Hengst, L; Kahn, H; Narod, S; Slingerland, J; Sun, J; Sun, P; Tan, CK	1
Lee, KA	1
Goldberg, GS; Ichikawa, H; Khusial, PR; Li, X; Moreno, AP; Shen, Y	1
Boureux, A; Leroy, C; Roche, S; Simon, V; Sirvent, A	1
Bhatia, R; Chu, S; Li, L; Singh, H	1
Bergsagel, PL; Chen, J; Cohen, MS; Dong, S; Fabbro, D; Gilliland, DG; Gu, TL; Guo, A; Kang, S; Khoury, HJ; Lonial, S; Polakiewicz, RD; Taunton, J	1
Goldblum, SE; Gong, P; Kalakonda, S; Kalvakolanu, DV; Lindner, DJ; Nallar, SC; Reddy, SP	1
Choi, S; Han, IO; Hwang, J; Jeon, J; Lee, H; Lee, JH; Oh, ES; Park, H	1
Girard, D; Ratthé, C	1
Chao, HP; Fu, SL; Kuo, CD; Liang, FP; Lin, CH	1
Clough, N; Cobos, E; Dai, Z; Sun, X; Tao, Y; Yu, W	1
Hassell, JA; Mes-Masson, AM; Schaffhausen, B	1
Gilmore, T; Martin, GS; Radke, K	1
Blomberg, J; Reynolds, FH; Stephenson, JR; Van de Ven, WJ	2
Blomberg, J; Nalewaik, RP; Reynolds, FH; Stephenson, JR; Van de Ven, WJ	1
Newmark, P	1
Marquardt, H; Reynolds, FH; Stephenson, JR; Todaro, GJ; Twardzik, DR	1
Albert, D; Chen, AP; de Noronha, F; Essex, M; Kelliher, M; Niederkorn, JY; Shadduck, JA	1
Hirano, A; Neil, JC; Vogt, PK	1
Rohrschneider, L; Rosok, MJ	1
Martinez, R; Nakamura, KD; Weber, MJ	1
Chen, AP; de Noronha, F; Essex, M	1
Bishop, JM; Snyder, MA	1
Comoglio, PM; Di Renzo, MF; Marchisio, PC	1
Hunter, T	1
Ihara, S; Ogawa, R; Ohtsuka, M; Watanabe, T; Watanabe, Y	1
Langan, T	1
Erikson, E; Erikson, RL	1
Barbacid, M; Lauver, AV	1
Cooper, JA; Esch, FS; Hunter, T; Patschinsky, T; Sefton, BM	1
Chamaret, S; Dauguet, C; Montagnier, L	1
Neil, JC	1
Toyoshima, K	1
Kawai, S	1
Caliguiri, LA; Garber, EA; Goldberg, AR; Lin, SL; Schellekens, H; Tamm, I; Wang, E	1
Mark, GE; Rapp, UR	1
Hinze, E; Pawson, T; Smith, M; Weinmaster, G; Zoller, MJ	1
Magee, PN; Nyce, J; Weinhouse, S	1
Lévy, JP	1
Bornstein, P; Casnellie, JE; Gallis, B; Krebs, EG; Marquardt, H; Pike, LJ; Todaro, GJ	1
Fujita, J; Maruyama, Y; Ogawa, K; Okuma, M; Sawada, H; Sawai, H; Tashima, M; Toi, T	1
Hayman, MJ; Morimoto, AM	1
Brewster, CE; Dilworth, SM; Jones, MD; Lanfrancone, L; Pelicci, G; Pelicci, PG	1
Brautigan, DL; Chen, J; Parsons, S	1
Goga, A; Havlik, M; McLaughlin, J; Sawyers, CL; Witte, O	1
Carlberg, K; Rohrschneider, L	1
Iyer, AP; Kochhar, KS; Linnekin, D	1
Huang, TS; Kuo, ML; Lin, JK; Yang, NC	1
Daniel, J; McCrea, PD; Reynolds, AB; Wheelock, MJ; Wu, J; Zhang, Z	1
Wang, LH; Zong, CS	1
Courtneidge, SA	1
Afar, DE; Maru, Y; Peters, KL; Shibuya, M; Smithgall, TE; Witte, ON	1
Calalb, MB; Hanks, SK; Polte, TR	1
Bibbins, KB; Boeuf, H; Murphy, J; Varmus, HE	1
Asai, N; Iwashita, T; Matsuyama, M; Takahashi, M	1
Avila, MA; Cho, C; Lupu, R; Notario, V; Velasco, JA; Wen, D	1
Havlik, MH; Li, T; Park, H; Satterthwaite, A; Takatsu, K; Tsukada, S; Witte, ON	1
Aaronson, SA; Alimandi, M; Curia, MC; Di Fiore, PP; Fedi, P; Kraus, MH; Muraro, R; Romano, A	1
Davis, RL; Denhardt, DT; Lopez, CA; Mou, K	1
Campbell, GS; Carter-Su, C; Jove, R; Larner, AC; Meyer, DJ; Schwartz, J; Yu, CL	1
Curpen, GD; Greenberg, AH; Hall, CL; Lange, LA; Samuel, S; Savani, RC; Turley, EA; Turley, M; Wang, C; Yang, B; Yang, X; Zhang, S	1
Burridge, K; Clark, GJ; Der, CJ; Kinch, MS	1
Bockholt, SM; Bouton, A; Burridge, K; Parsons, JT; Petch, LA	1
Bacus, SS; Chang, CJ; Hung, MC; Zhang, L	1
Ruoslahti, E; Vuori, K	1
Guan, JL; Verderame, MF; Woods Ignatoski, KM	1
Chang, JS; Iwashita, S; Kobayashi, M; Maruta, H; Wang, DZ	1
Alvarez, CV; Beguinot, L; Miloso, M; Shon, KJ	1
Nakano, H; Sharma, S; Zhao, JF	1
Alberti, L; Arighi, E; Bocciardi, R; Bongarzone, I; Borrello, MG; Greco, A; Luo, Y; Miranda, C; Mondellini, P; Pasini, B	1
Chang, JH; Niemann, H; Parsons, SJ; Smola, U; Tamura, T; Trouliaris, S	1
Baserga, R; Burgaud, JL; Miura, M; Surmacz, E	1
Birnbaum, D; Borg, JP; Dubreuil, P; Fournier, E	1
Arighi, E; Bongarzone, I; Borrello, MG; Carcano, C; Della Porta, G; Ferraresi, G; Mondellini, P; Monzini, N; Pierotti, MA	1
Hung, MC; Matin, A	1
Fukui, Y; Hanafusa, H; Scholz, G; Sternberg, DW	1
Engleka, KA; Forough, R; Friedman, S; Maciag, T; MacPhee, M; Sayers, T; Wiltrout, RH; Xi, Z	1
Havlik, MH; Muller, AJ; Parmar, K; Pendergast, AM; Rosenberg, N; Witte, ON	1
Cool, DE; Diltz, CD; Fischer, EH; Krebs, EG; Rohrschneider, LR; Zander, NF	1
Greathead, P; Pories, SE; Simpson, H; Steele, G; Summerhayes, IC; Weber, TK	1
Areces, LB; Feldman, RA; Jücker, M; Miyajima, A; Mui, A; San Miguel, JA	1
Bruder, J; Foster, DA; Gupta, R; Hendrickson, M; Joseph, CK; Qureshi, SA; Rapp, U; Song, J	1
Chan, TC; Chang, CJ; Geahlen, RL; Koonchanok, NM	1
Hung, MC; Reardon, DB	1
Barbacid, M; Bustelo, XR; Pawson, T; Suen, KL	1
Di Fiore, PP; Fazioli, F; Matoskova, B; Minichiello, L; Wong, WT	1
DeClue, JE; Johnson, MR; Lowy, DR; Stacey, DW; Vass, WC	1
Gelman, IH; Hanafusa, H; Khan, S	1
Donehower, LA; Hansen, MF; Hudson, E; Jeffers, M; Resau, JH; Rong, S; Strong, L; Tainsky, M; Tsarfaty, I; Vande Woude, GF	1
Connolly, DC; Maihle, NJ; McManus, MJ	1
Liu, W; Roberts, TM; Schaffhausen, BS; Su, W	1
Fincham, VJ; Frame, MC; Wyke, JA	1
Hung, MC; Li, K; Xie, Y	1
Binari, R; Gilman, M; Harrison, DA; Nahreini, TS; Perrimon, N	1
Chang, CM; Kung, HJ; Pelley, RJ; Ravi, L; Shu, H; Shu, HK	1
Baserga, R; Li, S; Miura, M	1
Fixman, ED; Moran, MF; Naujokas, MA; Park, M; Rodrigues, GA	1
Clark, SS; Liang, Y	1
Andoniou, CE; Langdon, WY; Thien, CB	1
Asano, Y; Enomoto, T	1
Ambroso, LA; Bridges, AJ; Connors, RW; Fry, DW; Kraker, AJ; Leopold, WR; McMichael, A; Nelson, JM	1
Hirai, H; Hirano, N; Iwamatsu, A; Mano, H; Ogawa, S; Sakai, R; Tanaka, T; Yazaki, Y	1
McGlade, J; Nicoletti, I; Pawson, T; Pelicci, G; Pelicci, PG; Salcini, AE	1
Beug, H; Hayman, MJ; Lee, EB	1
Arlinghaus, R; Bowtell, D; Gish, G; Liu, J; Mbamalu, G; Pawson, T; Pelicci, PG; Puil, L	1
Davidson, D; Fournel, M; Veillette, A	1
Afar, DE; Goga, A; McLaughlin, J; Sawyers, CL; Witte, ON	1
Annen, K	1
Arighi, E; Bongarzone, I; Borrello, MG; De Filippis, L; Greco, A; Pelicci, G; Pelicci, PG; Pierotti, MA; Rizzetti, M	1
Park, M; Rodrigues, GA	1
Baltimore, D; Jackson, P; Picard, D	1
Liu, D; Rutter, WJ; Wang, LH	1
Gotoh, B; Hamaguchi, M; Matsuyoshi, N; Nagai, Y; Ohnishi, Y; Takeichi, M	1
Katamine, S; Kohno, T; Miyamoto, T; Miyazaki, Y; Moriuchi, R; Tomonaga, M	1
Appella, E; Di Fiore, PP; Fazioli, F; Sakaguchi, K; Ullrich, SJ; Wong, WT	1
Baltimore, D; Jackson, PK; Paskind, M	1
Kamikura, DM; Naujokas, MA; Park, M	1
Chan, JL; Jiang, Y; Wang, LH; Zong, CS	1
Burridge, K; Kinch, MS	1
Grunicke, HH; Obermeier, A; Tinhofer, I; Ullrich, A	1
Denning, MF; Dlugosz, AA; Magnuson, T; Threadgill, DW; Yuspa, SH	1
Dent, P; Jelinek, T; Sturgill, TW; Weber, MJ	1
Asai, N; Iwashita, T; Matsuyama, M; Murakami, H; Takahashi, M	1
Carlesso, N; Frank, DA; Griffin, JD	1
Asai, N; Iwashita, T; Murakami, H; Takahashi, M	1
Alblas, J; Moolenaar, WH; van Etten, I	1
Chan-Hui, PY; Frisch, SM; Ruoslahti, E; Vuori, K	1
Huang, HP; Lin, YL; Shiow, SJ; Tseng, TH; Wang, CJ	1
Arlinghaus, RB; Laneuville, P; Liu, J; Wilson-Rawls, J; Xie, S	1
Katzav, S	1
Gilliland, DG; Golub, TR; Griffin, JD; Okuda, K	1
Garrison, JC; Woodring, PJ	1
Frank, DA; Varticovski, L	1
Greulich, H; Hanafusa, H	1
Kasid, U; Patel, BK; Ray, S; Whiteside, TL	1
Di Fiore, PP; Lai, KM; Lanfrancone, L; Mele, S; Migliaccio, E; Pawson, T; Pelicci, G; Pelicci, PG; Salcini, AE; Superti-Furga, G	1
Hamaguchi, M; Hanafusa, H; Sabe, H	1
Gilmer, TM; Kanner, SB; Lansing, TJ; Turk, BF	1
Jain, SK; Langdon, WY; Varticovski, L	1
Langdon, WY; Thien, CB	1
Blakesley, VA; Esposito, DL; Koval, AP; LeRoith, D; Scrimgeour, AG	1
Davis, JG; Greene, MI; Kajino, K; Kajino, Y; O'Rourke, DM; Wang, Q; Weber, BL; Zhang, HB; Zhang, HT; Zhang, X; Zhao, HZ	1
Barnard, D; Diaz, B; Filson, A; King, A; MacDonald, S; Marshall, M	1
Fixman, ED; Fournier, TM; Holgado-Madruga, M; Kamikura, DM; Nguyen, L; Park, M; Wong, AJ	1
Birnbaum, D; Blaikie, PA; Borg, JP; Dilworth, SM; Fournier, E; Margolis, B	1
Feltkamp, CA; McCarthy, JB; Meijne, AM; Roos, E; Ruuls-Van Stalle, L	1
Blackmore, V; Dankort, DL; Moran, MF; Muller, WJ; Wang, Z	1
Sabe, H	1
Hashimoto, Y; Kizaka-Kondoh, S; Kurata, T; Matsuda, M; Nagashima, K; Nishihara, H; Okayama, H; Ota, S	1
Anderson, DH; Ismail, PM	1
Desiderio, S; Dintzis, H; Dordai, DI; Malek, SN; Reim, J	1
Davis, JG; Greene, MI; Mikami, Y; Murali, R; O'Rourke, DM; Qian, X; Zhang, HT; Zhao, H	1
Kilpatrick, KE; Kinch, MS; Zhong, C	1
Flechner, L; Jiang, YX; Kapoor, V; Li, W; Pierce, JH; Soon, L; Wang, LH; Zhang, J	1
Bustelo, XR; Movilla, N; Rosa, JL; Schuebel, KE	1
Fiscella, M; Jeffers, M; Koochekpour, S; Sathyanarayana, BK; Vande Woude, GF	1
Boeuf, H; Chenard, MP; Moog-Lutz, C; Régnier, CH; Rio, MC; Schreiber, V; Tomasetto, C; Vonesch, JL	1
Berger, SA; Chow, RY; Lam, LP	1
Hayman, MJ; Park, CY	1
Anderson, SM; Lee, RC; Reyland, ME; Walters, JA	1
Bhat, A; Druker, BJ; Heaney, C; Kolibaba, KS; Oda, T	1
Cartwright, CA; Peng, ZY; Walter, AO	1
Hung, MC; Lo, SH; Lo, SS; Wang, SC	1
Bowtell, DD; Dominguez, MG; Lee, PS; Murphy, MA; Stanley, ER; Wang, Y; Yeung, YG	1
Bouton, AH; Burnham, MR; Harte, MT	1
Paik, PK; Samelson, LE; van Leeuwen, JE	1
Mahudawala, DM; Rao, KV	1
Cortizo, AM; Etcheverry, SB; Gómez Dumm, CL; Sálice, VC	1
Bardelli, A; Gual, P; Longati, P; Michieli, P; Pugliese, L; Williams, TA	1
Cong, F; Goff, SP; Yuan, B	1
Chang, JS; Iwashita, S; Kim, MJ; Lee, YH; Ryu, SH; Suh, PG	1
Pear, WS	1
Aster, JC; Cain, D; Carroll, M; Gilliland, DG; Ilaria, RL; Sternberg, DW; Tomasson, MH; Van Etten, RA; Williams, IR	1
Lionberger, JM; Smithgall, TE	1
Chen, Yh; Goodenough, DA; Lu, Q; Schneeberger, EE	1
Bertics, PJ; Guadarrama, AG; Kim, YN; Wiepz, GJ	1
Ahn, H; Ko, Y; Sachinidis, A; Seewald, S; Seul, C; Vetter, H	1
Aster, JC; Cain, D; Gilliland, DG; Kutok, J; Liu, Q; Schwaller, J; Williams, IR	1
Acs, P; Beheshti, M; Blumberg, PM; Li, L; Szállási, Z; Yuspa, SH	1
Mukherjee, G; Small, D; Tse, KF	1
Erwin, RA; Farrar, WL; Kirken, RA; Rui, H; Wang, L; Wang, Y	1
Lisanti, MP; Pestell, RG; Schlegel, A	1
Fässler, R; Jove, R; Mosher, DF; Sakai, T	1
Dankort, DL; Khoury, H; Muller, WJ; Naujokas, MA; Park, M; Sadekova, S	1
Boynton, AL; Golard, A; Hossain, MZ; Huang, R; Huang, RP; Liu, YG; Peng, A	1
Hamada, M; Kosaka, N; Nakano, H; Oneyama, C; Sharma, SV; Sugawara, K; Tamaoki, T; Yamashita, Y	1
Alberti, L; Arighi, E; Borrello, MG; Ghizzoni, S; Gishizky, ML; Mercalli, E; Pierotti, MA; Radice, MT; Sangregorio, R	1
Bohmer, FD; Civin, CI; Novelli, E; Small, D; Tse, KF	1
Danilkovitch-Miagkova, A; Leonard, EJ; Miagkov, A; Nakaigawa, N; Skeel, A; Zbar, B	1
Dankort, D; Dumont, DJ; Jeyabalan, N; Jones, N; Muller, WJ	1
Buys, CH; Hagens, W; Hofstra, R; Kruijer, W; Schuringa, JJ; Vellenga, E; Wojtachnio, K	1
Aznar, S; del Rincon, SV; Lacal, JC; Pérez, LF; Perona, R; Valerón, PF	1
Bedford, MT; Lee, H; Lisanti, MP; Petrucci, T; Sotgia, F; Sudol, M	1
Chen, SH; Liang, YC; Lin, CL; Liu, JD; Tsai, SH	1
Fernandis, AZ; Krishnamurthy, SC; Prabhudesai, S; Rao, KV; Subrahmanyam, G; Sundarrajan, M	1
Han, I; Kwon, HJ; Lim, Y; Oh, ES	1
Koch, A; Mancini, A; Tamura, T; Wilms, R	1
Arteaga, CL; Khuri, F; Krystal, G; Sebti, S	1
Danielsen, AJ; Maihle, NJ	1
Choi, JK; He, Y; Karnell, FG; Miller, JP; Pear, WS; Ren, R; Wertheim, JA; Xu, L	1
Akhand, AA; Hamaguchi, M; Iwashita, T; Kato, M; Kawamoto, Y; Nakashima, I; Senga, T; Sobue, G; Takahashi, M; Takeda, K; Yamamoto, M	1
Asano, S; Iijima, Y; Kruh, GD; Okuda, K; Sakaki, Y; Sato, Y; Setoyama, M; Tojo, A; Tokunaga, K; Tri, NK	1
Bauer, G; Bechtel, W; Heigold, S; Ivanovas, B; Schäfer, R; Sers, C	1
Katze, JR	2
Pawelek, JM	1
Baker, ME	1
Glenney, JR; Soppet, D	1
Chou, MM; Fajardo, JE; Hanafusa, H	1
Andersson, LC; Auvinen, M; Hölttä, E; Paasinen, A	1
Baltimore, D; Jackson, PK; Mayer, BJ; Van Etten, RA	1
Dixon, JE; Rhodes, JD; Woodford-Thomas, TA	1
Brugge, JS; Foster, DA; Maroney, AC; Qureshi, SA	1
Calautti, E; Dotto, GP; Filvaroff, E; McCormick, F	1
Beppu, T; Fukui, Y; Horinouchi, S; Kwon, HJ; Yoshida, M	1
Anderson, D; Koch, CA; Liu, XQ; Mbamalu, G; Moran, MF; Pawson, T	1
Iwamoto, T; Matsuyama, M; Nakashima, I; Nakayama, A; Ohbayashi, M; Takahashi, M; Taniguchi, M	1
Kozma, LM; Reynolds, AB; Weber, MJ	1
Ellis, C; McCormick, F; Moran, M; Pawson, T	1
Dutta, A; Hamaguchi, M; Hanafusa, H	1
Brugge, J; Ferracini, R	1
Cohen, B; Piwnica-Worms, H; Roberts, TM; Schaffhausen, BS; Yoakim, M	1
Hanafusa, H; Mayer, BJ	1
Engelman, A; Rosenberg, N	1
Aaronson, SA; Giese, N; LaRochelle, WJ; May-Siroff, M; Robbins, KC	1
Fitzgerald, DL; Payne, DM; Wasilenko, WJ; Weber, MJ	1
Baltimore, D; Jackson, PK; Mayer, BJ	1
Kanner, SB; Parsons, JT; Reynolds, AB	1
Bouton, AH; Gibbs, JB; Kanner, SB; Parsons, JT; Vines, RR; Wang, HC	1
Hirai, H; Varmus, HE	1
Hanafusa, H; Matsuda, M; Mayer, BJ	1
Alitalo, K; Comoglio, PM; Di Renzo, MF; Koskinen, P; Lehtola, L; Lehväslaiho, H; Sistonen, L	1
Li, W; Stanley, ER; Yeung, YG	1
Abraham, KM; Forbush, KA; Levin, SD; Marth, JD; Perlmutter, RM	1
Bouton, AH; Kanner, SB; Parsons, JT; Vines, RR	1
Havlik, MH; Maru, Y; Muller, AJ; Pendergast, AM; Witte, ON	1
Faller, DV; Mundschau, LJ; Quiñones, MA; Rake, JB	1
Aaronson, SA; Arnstein, P; Artrip, J; Di Fiore, PP; DiMarco, E; Kraus, MH; Lonardo, F; Pierce, JH	1
Hanafusa, H	1
Kozma, LM; Rossomando, AJ; Weber, MJ	1
Downing, JR; Reynolds, AB	1
Hamaguchi, M; Iwamoto, T; Matsuyama, M; Takahashi, M; Taniguchi, M	1
Kanner, SB; Parsons, JT; Reynolds, AB; Vines, RR	1
Kaplan, DR; McCormick, F; Morrison, DK; Williams, LT; Wong, G	1
Hyrc, K; Rose, B	1
Hayman, MJ; Lee, EB	1
Bover, L; Guerra, L; Mordoh, J	1
Chardin, P; Frech, M; John, J; Rösch, P; Schlichting, I; Wittinghofer, A; Zimmermann, H	1
Klarlund, JK	1
Cartwright, CA; Cooper, JA; Gould, KL; Hunter, T	1
Chieco-Bianchi, L; Comoglio, PM; Di Renzo, MF; Ferracini, R; Naldini, L; Saggioro, D	1
Comoglio, PM; Di Renzo, MF; Ferracini, R; Giordano, S; Naldini, L	1
Wang, JY	1
Cartwright, CA; Cooper, JA; Eckhart, W; Hunter, T; Kaplan, PL	1
Bauer, H; Niemann, H; Simon, E; Snoek, GT; Tamura, T	1
Kipreos, ET; Lee, GJ; Wang, JY	1
Cantley, L; Kaplan, DR; Pallas, DC; Roberts, TM; Schaffhausen, B; White, M; Whitman, M	1
Browning, PJ; Morrison, DK; Roberts, TM; White, MF	1
Comoglio, PM; Di Renzo, MF; Gaudino, G	1
Comoglio, PM; D'Urso, N; Giancotti, FG; Marchisio, PC; Tarone, G	1
Kaplan, JM; Varmus, HE; Verderame, MF	1
Deuel, TF; Kawahara, RS; Pierce, GF; Shawver, LK	1
Mizuno, S; Murakami, Y; Sugimoto, Y; Uehara, Y	1
Cao, H; Kamps, MP; Stern, DF	1
Billings, PC; Kennedy, AR; Morrow, AR; Ryan, CA	1
Gilmer, TM; Kanner, SB; Parsons, JT; Reynolds, AB	1
Lau, AF	1
Glenney, JR	1
Gavazzi, I; Marchisio, PC; Nermut, MV	1
Levin, SD; Perlmutter, RM; Ziegler, SF	1
Boerkoel, C; Carter, TH; Kung, HJ; Maihle, NJ; Moscovici, C; Pelley, RJ; Shu, HK	1
Benjamin, TL; Dahl, J; Dawe, CJ; Freund, R; Talmage, DA; Young, AT	1
Barbacid, M; Hedge, AM; Ihle, JN; Isfort, R; Katzav, S; Martin-Zanca, D	1
Cohen, B; Druker, B; Kaplan, D; Keller, T; Mamon, H; Morgan, W; Piwnica-Worms, H; Roberts, TM; Schaffhausen, B; Whitman, M	1
Downing, JR; Rettenmier, CW; Roussel, MF; Sherr, CJ	1
Benjamin, TL; Carmichael, GG; Liang, TJ; Schaffhausen, BS	1
DeClue, JE; Martin, GS	1
Nigg, EA; Sefton, BM; Singer, SJ; Vogt, PK	1
Cheng, SH; Piwnica-Worms, H; Roberts, TM; Saunders, KB; Smith, AE	1
Bertics, PJ; Gill, GN; Santon, JB	1
Amrein, KE; Sefton, BM	1
Ben-Ze'ev, A	1
Korfsmeier, KH	1
Narurkar, LM; Narurkar, MV; Shetty, TK	1
Edmund, J; Egeberg, J; Jensen, OA	1
Goldman, M; Griffin, AC	1
Gallo, RC	1
Matsushima, T; Weisburger, JH	1

Reviews

25 review(s) available for tyrosine and Cell Transformation, Neoplastic

Article	Year
Protein Tyrosine Phosphatase 1B (PTP1B): Insights into its New Implications in Tumorigenesis. Current cancer drug targets, 2022, Volume: 22, Issue:3 Topics: Cell Transformation, Neoplastic; Humans; Neoplasms; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Tyrosine	2022
Recent progress in the imaging of c-Met aberrant cancers with positron emission tomography. Medicinal research reviews, 2022, Volume: 42, Issue:4 Topics: Cell Transformation, Neoplastic; Humans; Neoplasms; Positron-Emission Tomography; Tyrosine	2022
Protein phosphorylation and its role in the regulation of Annexin A2 function. Biochimica et biophysica acta. General subjects, 2017, Volume: 1861, Issue:11 Pt A Topics: Annexin A2; Cell Transformation, Neoplastic; Exosomes; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Ribonucleoproteins; S100 Proteins; Serine; Tyrosine	2017
Role of nitric oxide in the radiation-induced bystander effect. Redox biology, 2015, Volume: 6 Topics: Bystander Effect; Cell Transformation, Neoplastic; Cysteine; DNA Damage; Eukaryotic Cells; Gamma Rays; Genomic Instability; Humans; Mutagenesis; Neoplasm Proteins; Nitric Oxide; Protein Processing, Post-Translational; Reactive Nitrogen Species; Signal Transduction; Tyrosine	2015
STAT3 revs up the powerhouse. Science signaling, 2009, Sep-29, Volume: 2, Issue:90 Topics: Animals; Cell Transformation, Neoplastic; Genes, ras; Humans; Mitochondria; Models, Biological; Oncogenes; Oxidative Phosphorylation; Phosphorylation; ras Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Tyrosine	2009
[Carcinogenic mechanisms of Helicobacter pylori]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2009, Volume: 54, Issue:8 Suppl Topics: Animals; Antigens, Bacterial; Bacterial Proteins; beta Catenin; Cell Polarity; Cell Transformation, Neoplastic; Gastric Mucosa; Helicobacter pylori; Humans; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Signal Transduction; Stomach Neoplasms; Tyrosine	2009
Viral immunoreceptor-associated tyrosine-based activation motifs: potential players in oncogenesis. Future oncology (London, England), 2006, Volume: 2, Issue:2 Topics: Amino Acid Motifs; Cell Transformation, Neoplastic; Humans; Neoplasm Proteins; NFATC Transcription Factors; Receptors, Immunologic; Signal Transduction; src Homology Domains; Tyrosine; Viral Proteins; Virus Replication	2006
Another piece of the p27Kip1 puzzle. Cell, 2007, Jan-26, Volume: 128, Issue:2 Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p27; Extracellular Space; Humans; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine	2007
Ewings family oncoproteins: drunk, disorderly and in search of partners. Cell research, 2007, Volume: 17, Issue:4 Topics: Cell Transformation, Neoplastic; Chromosome Aberrations; Humans; Mutation; Oncogene Proteins, Fusion; Phosphorylation; Protein Binding; Protein Folding; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Sarcoma, Ewing; Transcription Factors; Transcriptional Activation; Tyrosine	2007
Defective avian sarcoma viruses. Current topics in microbiology and immunology, 1983, Volume: 103 Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Chickens; Defective Viruses; Genes, Viral; Mutation; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Protein Kinases; Sarcoma, Avian; Temperature; Tyrosine; Viral Proteins	1983
[Development of oncogene study]. Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:2 Pt 2 Topics: Animals; Avian Sarcoma Viruses; Cats; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA, Viral; Genes, Viral; Mice; Neoplasm Proteins; Oncogenes; Operon; Phosphorylation; Phosphotransferases; Rabbits; Rats; Retroviridae; RNA, Viral; Tyrosine	1983
[Oncogene expression and cell transformation]. Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:2 Pt 2 Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, Viral; Mice; Molecular Weight; Neoplasm Proteins; Oncogenes; Protein Kinases; Proteins; Rats; Tyrosine	1983
5-Methylcytosine depletion during tumour development: an extension of the miscoding concept. British journal of cancer, 1983, Volume: 48, Issue:4 Topics: 5-Methylcytosine; Alkylation; Amino Acid Metabolism, Inborn Errors; Animals; Carcinogens; Cell Transformation, Neoplastic; Choline Deficiency; Cytosine; DNA; DNA Repair; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Models, Genetic; Neoplasms; Oncogenes; Rats; Tyrosine; Vitamin B 6 Deficiency	1983
[Oncogenes. 1]. Nouvelle revue francaise d'hematologie, 1984, Volume: 26, Issue:1 Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromosome Mapping; Chromosomes, Human; DNA, Viral; Gene Expression Regulation; Humans; Neoplasms; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Protein Kinases; Retroviridae; Tyrosine; Viral Proteins	1984
Protein tyrosine kinases, with emphasis on the Src family. Seminars in cancer biology, 1994, Volume: 5, Issue:4 Topics: Animals; Cell Transformation, Neoplastic; CSK Tyrosine-Protein Kinase; Humans; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src-Family Kinases; Tyrosine	1994
Altered adhesions in ras-transformed breast epithelial cells. Biochemical Society transactions, 1995, Volume: 23, Issue:3 Topics: Breast; Cell Adhesion; Cell Transformation, Neoplastic; Epithelial Cells; Female; Genes, ras; Humans; Intercellular Junctions; Phenotype; Phosphorylation; Tyrosine	1995
Vav: Captain Hook for signal transduction? Critical reviews in oncogenesis, 1995, Volume: 6, Issue:2 Topics: Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Gene Expression; Hematopoiesis; Hematopoietic Stem Cells; Humans; Mice; Mice, Nude; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Signal Transduction; Tyrosine	1995
[Cell to substratum adhesion signaling]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1997, Volume: 42, Issue:10 Suppl Topics: Animals; Cell Adhesion; Cell Transformation, Neoplastic; Cytokines; Humans; Integrins; Phosphorylation; Signal Transduction; Tyrosine	1997
Caveolins in cholesterol trafficking and signal transduction: implications for human disease. Frontiers in bioscience : a journal and virtual library, 2000, Dec-01, Volume: 5 Topics: Animals; Biological Transport; Caveolin 1; Caveolins; Cell Transformation, Neoplastic; Cholesterol; Humans; Phosphorylation; Protein Structure, Tertiary; Signal Transduction; Tyrosine	2000
Overview of rationale and clinical trials with signal transduction inhibitors in lung cancer. Seminars in oncology, 2002, Volume: 29, Issue:1 Suppl 4 Topics: Alkyl and Aryl Transferases; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Transformation, Neoplastic; Clinical Trials as Topic; Disease Progression; Enzyme Inhibitors; ErbB Receptors; Farnesyltranstransferase; Humans; Lung Neoplasms; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Research Design; Signal Transduction; Tyrosine; Up-Regulation	2002
Factors regulating growth and pigmentation of melanoma cells. The Journal of investigative dermatology, 1976, Volume: 66, Issue:4 Topics: Animals; Bone Neoplasms; Bromodeoxyuridine; Catechol Oxidase; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cyclic AMP; Dihydroxyphenylalanine; Melanins; Melanocyte-Stimulating Hormones; Melanocytes; Melanoma; Mice; Neoplasms, Experimental; Oncogenic Viruses; Pigmentation; Tyrosine	1976
Protein phosphorylation and cell transformation. Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology, 1991, Volume: 24, Issue:1 Topics: 1-Phosphatidylinositol 4-Kinase; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, src; Humans; Neoplasm Proteins; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Binding; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine	1991
Protein tyrosine kinases associated with human malignancies. Annals of the New York Academy of Sciences, 1987, Volume: 511 Topics: Antibodies, Neoplasm; Carcinoma, Small Cell; Cell Division; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Humans; Leukemia, Myeloid; Neoplasm Proteins; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Bombesin; Receptors, Cell Surface; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Tyrosine	1987
Epidermal growth factor and its receptor. Molecular and cellular endocrinology, 1987, Volume: 51, Issue:3 Topics: Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Amplification; Humans; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogenes; Threonine; Tyrosine	1987
The cytoskeleton in cancer cells. Biochimica et biophysica acta, 1985, Volume: 780, Issue:3 Topics: Actins; Animals; Cell Adhesion; Cell Transformation, Neoplastic; Cytoskeleton; DNA; Fibronectins; Humans; Microtubule Proteins; Microtubules; Mutation; Neoplasms; Oncogenes; Phenotype; Phosphorylation; Tropomyosin; Tyrosine	1985

Other Studies

371 other study(ies) available for tyrosine and Cell Transformation, Neoplastic

Article	Year
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. Cancer letters, 2022, 05-01, Volume: 533 Topics: Apoptosis; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glioblastoma; Humans; Phosphorylation; STAT3 Transcription Factor; Tyrosine	2022
FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. eLife, 2022, 05-12, Volume: 11 Topics: Carcinogenesis; Carcinoma, Ovarian Epithelial; Cell Transformation, Neoplastic; Enzyme Activation; Female; Humans; Insulin Receptor Substrate Proteins; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Tyrosine	2022
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin. Signal transduction and targeted therapy, 2023, 02-17, Volume: 8, Issue:1 Topics: beta Catenin; Carcinogenesis; Cell Transformation, Neoplastic; Humans; Neoplasm Proteins; Pancreatic Neoplasms; Phosphorylation; src-Family Kinases; Tyrosine; Wnt Signaling Pathway	2023
Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats. Scientific reports, 2020, 01-21, Volume: 10, Issue:1 Topics: Administration, Oral; alpha-Tocopherol; Animals; Bile Duct Neoplasms; Bile Ducts; Cell Transformation, Neoplastic; Cholangiocarcinoma; Cholestasis; Feces; Gastrointestinal Microbiome; Gene Expression Regulation; Humans; Omeprazole; Proton Pump Inhibitors; Rats, Wistar; Retinoid X Receptor alpha; RNA-Binding Proteins; RNA, Ribosomal, 16S; Tyrosine	2020
Site-Selective Protein Chemical Modification of Exposed Tyrosine Residues Using Tyrosine Click Reaction. Bioconjugate chemistry, 2020, 05-20, Volume: 31, Issue:5 Topics: Animals; Binding Sites; Biocatalysis; Cell Line, Tumor; Cell Transformation, Neoplastic; Click Chemistry; Electron Transport; Horseradish Peroxidase; Humans; Luminol; Male; Methylation; Mice; Models, Molecular; Protein Conformation; Proteins; Tyrosine	2020
Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1. Cancer research, 2017, 09-15, Volume: 77, Issue:18 Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Adhesion; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Cells, Cultured; Female; HEK293 Cells; Hippo Signaling Pathway; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Staging; Phosphoproteins; Phosphorylation; Prognosis; Protein Serine-Threonine Kinases; Signal Transduction; src-Family Kinases; Transcription Factors; Tyrosine; Xenograft Model Antitumor Assays; YAP-Signaling Proteins	2017
Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis. Leukemia, 2018, Volume: 32, Issue:3 Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Fusion Proteins, bcr-abl; Guanine Nucleotide Exchange Factors; Humans; Leukemia; Mice; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rac1 GTP-Binding Protein; SOS1 Protein; Tyrosine	2018
v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling. Scientific reports, 2018, 01-18, Volume: 8, Issue:1 Topics: Animals; Cell Adhesion; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosome Aberrations; Cyclin-Dependent Kinase Inhibitor Proteins; Gene Expression Regulation; Humans; Mice; NIH 3T3 Cells; Oncogene Protein pp60(v-src); Phosphorylation; Signal Transduction; Tyrosine	2018
The diagnostic accuracy of detecting malignant transformation of low-grade glioma using O-(2-[18F]fluoroethyl)-l-tyrosine positron emission tomography: a retrospective study. Journal of neurosurgery, 2018, 04-06, Volume: 130, Issue:2 Topics: Adult; Biomarkers, Tumor; Brain Neoplasms; Cell Transformation, Neoplastic; Female; Glioma; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Grading; Oligodendroglia; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Reproducibility of Results; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Treatment Outcome; Tyrosine	2018
Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2. Annals of nuclear medicine, 2019, Volume: 33, Issue:6 Topics: Animals; Blood Circulation; Boron Compounds; Cell Line, Tumor; Cell Transformation, Neoplastic; Glioma; Humans; Large Neutral Amino Acid-Transporter 1; Male; Pancreatic Neoplasms; Phenylalanine; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals; Rats; Tissue Distribution; Tyrosine	2019
Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation. The Journal of biological chemistry, 2013, Sep-27, Volume: 288, Issue:39 Topics: Animals; Calorimetry; Cell Transformation, Neoplastic; ETS Translocation Variant 6 Protein; Humans; Lysine; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Mutation; NIH 3T3 Cells; Polymers; Protein Structure, Tertiary; Proto-Oncogene Proteins c-ets; Receptor, trkC; Repressor Proteins; Salts; Signal Transduction; Static Electricity; Tyrosine	2013
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner. Oncogene, 2014, Nov-13, Volume: 33, Issue:46 Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; Class Ia Phosphatidylinositol 3-Kinase; COS Cells; Female; Mice, Inbred Strains; Mice, Nude; Morpholines; Mutation, Missense; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-kit; Quinazolines; RNA Interference; Serine; Tyrosine	2014
Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis. Molecular carcinogenesis, 2015, Volume: 54, Issue:5 Topics: Animals; Anoikis; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 8; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Focal Adhesion Kinase 1; Immunoenzyme Techniques; Immunoprecipitation; Mice; Mutation; Oligopeptides; Osteopontin; Phosphorylation; Tyrosine	2015
The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. Oncogene, 2015, Aug-27, Volume: 34, Issue:35 Topics: Amino Acid Motifs; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Humans; MAP Kinase Signaling System; Mice, Nude; Mutation, Missense; Phosphorylation; Protein Processing, Post-Translational; Proteolysis; Proto-Oncogene Proteins c-kit; STAT5 Transcription Factor; Tumor Burden; Tyrosine	2015
18F-FET microPET and microMRI for anti-VEGF and anti-PlGF response assessment in an orthotopic murine model of human glioblastoma. PloS one, 2015, Volume: 10, Issue:2 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Magnetic Resonance Imaging; Membrane Proteins; Mice; Microvessels; Multimodal Imaging; Optical Imaging; Positron-Emission Tomography; RNA, Messenger; Survival Analysis; Tomography, X-Ray Computed; Treatment Outcome; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1	2015
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature, 2015, May-21, Volume: 521, Issue:7552 Topics: Amino Acid Motifs; Animals; Antigens, CD; B-Lymphocytes; Cell Death; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Activation; Female; Fusion Proteins, bcr-abl; Gene Deletion; Humans; Inositol Polyphosphate 5-Phosphatases; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Platelet Endothelial Cell Adhesion Molecule-1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Receptors, Immunologic; Signal Transduction; Syk Kinase; Tyrosine; Xenograft Model Antitumor Assays	2015
Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer. PloS one, 2015, Volume: 10, Issue:6 Topics: Blotting, Western; Breast Neoplasms; Carcinoma, Renal Cell; Catenins; Cell Transformation, Neoplastic; Delta Catenin; Female; Humans; Immunoenzyme Techniques; Immunoprecipitation; Kidney Neoplasms; Phosphoproteins; Phosphorylation; Protein Binding; Serine; Threonine; Tissue Array Analysis; Tumor Cells, Cultured; Tyrosine	2015
Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxidants & redox signaling, 2015, Nov-10, Volume: 23, Issue:14 Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Proliferation; Cell Shape; Cell Transformation, Neoplastic; Diethylnitrosamine; Hep G2 Cells; Hepatocytes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms, Experimental; Male; Mice, Knockout; Mitochondria; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine; Wnt Signaling Pathway	2015
Comparison of (18)F-FET and (18)F-FLT small animal PET for the assessment of anti-VEGF treatment response in an orthotopic model of glioblastoma. Nuclear medicine and biology, 2016, Volume: 43, Issue:3 Topics: Animals; Bevacizumab; Brain Neoplasms; Cell Transformation, Neoplastic; Dideoxynucleosides; Female; Glioblastoma; HEK293 Cells; Humans; Mice; Microvessels; Positron-Emission Tomography; Survival Analysis; Tyrosine; Vascular Endothelial Growth Factor A	2016
Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. Oncotarget, 2016, Apr-26, Volume: 7, Issue:17 Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Colon; Colonic Neoplasms; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Stability; src-Family Kinases; Transplantation, Heterologous; Tyrosine	2016
Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors. PloS one, 2016, Volume: 11, Issue:11 Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Activation; Fibroblasts; Humans; Mutant Proteins; Mutation; Phosphorylation; Protein Isoforms; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Receptor, IGF Type 1; Signal Transduction; src-Family Kinases; Thyroid Neoplasms; Tumor Stem Cell Assay; Tyrosine	2016
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD. Cellular and molecular life sciences : CMLS, 2017, Volume: 74, Issue:14 Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; fms-Like Tyrosine Kinase 3; Gene Duplication; Humans; Male; Mice, Inbred BALB C; Mutant Proteins; Mutation; Myeloid Cells; Oncogenes; Phosphorylation; Protein Stability; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proteolysis; Signal Transduction; Tyrosine; Ubiquitination	2017
Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jul-15, Volume: 14, Issue:14 Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Signal Transduction; STAT5 Transcription Factor; Structure-Activity Relationship; Tyrosine	2008
TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. Toxicology, 2008, Oct-30, Volume: 252, Issue:1-3 Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Blotting, Western; Bronchi; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Databases, Protein; Electrophoresis, Gel, Two-Dimensional; Epithelial Cells; Gene Expression; Humans; Immunohistochemistry; Immunoprecipitation; Isoelectric Focusing; Microtubule-Associated Proteins; Mutagens; Nuclear Proteins; Phosphorylation; RNA Interference; RNA, Small Interfering; Sister Chromatid Exchange; Tyrosine	2008
Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation. Cancer research, 2008, Oct-01, Volume: 68, Issue:19 Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mutant Proteins; Phosphorylation; Point Mutation; Prostatic Neoplasms; Protein-Tyrosine Kinases; Serine; STAT3 Transcription Factor; Transplantation, Heterologous; Tyrosine	2008
Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. PloS one, 2008, Volume: 3, Issue:10 Topics: Animals; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p27; Embryonic Stem Cells; Humans; Mice; Mice, Knockout; Neoplasms; Phosphorylation; Predictive Value of Tests; Prognosis; ras Proteins; STAT1 Transcription Factor; Transcription, Genetic; Tyrosine	2008
Inhibition of NF-kappaB signaling via tyrosine phosphorylation of Ymer. Biochemical and biophysical research communications, 2009, Jan-23, Volume: 378, Issue:4 Topics: Cell Line; Cell Transformation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Mutation; NF-kappa B; Phosphorylation; Signal Transduction; src-Family Kinases; Tyrosine	2009
A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:2 Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Tocopherol; Inflammation; Leukotriene B4; Male; Mice; Tyrosine	2009
Deletion of the ectodomain unleashes the transforming, invasive, and tumorigenic potential of the MET oncogene. Cancer science, 2009, Volume: 100, Issue:4 Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Green Fluorescent Proteins; Immunohistochemistry; Keratins; Lentivirus; MAP Kinase Signaling System; Mice; Mice, Nude; NIH 3T3 Cells; Phosphorylation; Plasmids; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Mas; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Sequence Deletion; Transduction, Genetic; Tyrosine; Vimentin; Xenograft Model Antitumor Assays	2009
Increased production and secretion of HGF alpha-chain and an antagonistic HGF fragment in a human breast cancer progression model. International journal of cancer, 2009, Sep-01, Volume: 125, Issue:5 Topics: Blotting, Western; Breast Neoplasms; Cell Transformation, Neoplastic; Culture Media, Conditioned; Disease Progression; Genes, ras; Hepatocyte Growth Factor; Humans; Mesoderm; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-met; Tyrosine	2009
A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. British journal of haematology, 2009, Volume: 146, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cell Survival; Cell Transformation, Neoplastic; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Signal Transduction; STAT5 Transcription Factor; Tumor Cells, Cultured; Tyrosine	2009
The juxtamembrane region of the EGF receptor functions as an activation domain. Molecular cell, 2009, Jun-26, Volume: 34, Issue:6 Topics: Animals; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; COS Cells; Crystallography, X-Ray; Dimerization; ErbB Receptors; Humans; Mice; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NIH 3T3 Cells; Phosphorylation; Protein Structure, Tertiary; Tyrosine	2009
Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene, 2010, Jan-14, Volume: 29, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Blotting, Western; Cell Culture Techniques; Cell Line; Cell Polarity; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Drug Resistance; Fibroblasts; Flow Cytometry; Humans; Mutation; Paclitaxel; Phosphorylation; Receptor, ErbB-2; Shc Signaling Adaptor Proteins; Tyrosine	2010
Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity. The Journal of biological chemistry, 2010, Jul-23, Volume: 285, Issue:30 Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cattle; Cell Transformation, Neoplastic; Enzyme Activation; Humans; Jurkat Cells; Mice; Molecular Sequence Data; Mutation; NFATC Transcription Factors; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-vav; Rats; T-Lymphocytes; Tyrosine	2010
pp60c-Src phosphorylates and activates vacuolar protein sorting 34 to mediate cellular transformation. Cancer research, 2010, Jul-15, Volume: 70, Issue:14 Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chlorocebus aethiops; COS Cells; Humans; Lipid Metabolism; Mice; Molecular Sequence Data; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Point Mutation; Proto-Oncogene Proteins pp60(c-src); Tyrosine	2010
Antisense inhibition of amphiregulin expression reduces EGFR phosphorylation in transformed human breast epithelial cells. Anticancer research, 2010, Volume: 30, Issue:6 Topics: Amphiregulin; Antisense Elements (Genetics); Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phosphorylation; Tyrosine	2010
Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:3 Topics: Apoptosis; Barrett Esophagus; Cell Line, Transformed; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Deoxycholic Acid; Epithelial Cells; Esophageal Neoplasms; Esophagitis; Esophagus; Genes, ras; Humans; Interleukin-6; Janus Kinases; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Telomerase; Time Factors; Transfection; Tumor Microenvironment; Tumor Suppressor Protein p53; Tyrosine	2011
Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation. Cellular signalling, 2011, Volume: 23, Issue:5 Topics: Amino Acid Substitution; Animals; bcl-X Protein; Cell Transformation, Neoplastic; Chromones; CREB-Binding Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Janus Kinase 2; Mice; Mice, Nude; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Myeloproliferative Disorders; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Point Mutation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Erythropoietin; Tyrosine	2011
Benzene metabolite 1,2,4-benzenetriol induces halogenated DNA and tyrosines representing halogenative stress in the HL-60 human myeloid cell line. Environmental health perspectives, 2012, Volume: 120, Issue:1 Topics: Aniline Compounds; Apoptosis; Catalase; Cell Transformation, Neoplastic; DNA; DNA Damage; Enzyme Inhibitors; Halogenation; HL-60 Cells; Humans; Hydroquinones; Methionine; Reactive Oxygen Species; Stress, Physiological; Tyrosine	2012
Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness. Molecular biology of the cell, 2011, Volume: 22, Issue:22 Topics: Animals; Cell Adhesion Molecules; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Green Fluorescent Proteins; Humans; Mice; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Signal Transduction; src Homology Domains; Tyrosine	2011
Abl-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion. The Biochemical journal, 2012, Feb-01, Volume: 441, Issue:3 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cytoskeletal Proteins; Focal Adhesions; Fusion Proteins, bcr-abl; HEK293 Cells; Humans; K562 Cells; Leukemia, Experimental; Mice; Microfilament Proteins; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-abl; Tyrosine; Xenopus laevis	2012
Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders. Leukemia, 2012, Volume: 26, Issue:4 Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Centrosome; Chronic Disease; Humans; Myeloproliferative Disorders; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Recombinant Fusion Proteins; Tyrosine	2012
Assessment of the transforming potential of novel anaplastic lymphoma kinase point mutants. Molecular carcinogenesis, 2013, Volume: 52, Issue:1 Topics: Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Fibroblasts; Humans; Mice; Neoplasms; Phosphorylation; Point Mutation; Receptor Protein-Tyrosine Kinases; Tyrosine	2013
Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. Molecular carcinogenesis, 2013, Volume: 52, Issue:1 Topics: 4-Nitroquinoline-1-oxide; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzoxepins; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Drugs, Chinese Herbal; ErbB Receptors; Limonins; Male; Matrines; Mice; Mouth Neoplasms; Phosphorylation; Pterocarpans; Quinolizines; Tyrosine	2013
Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease. Leukemia, 2012, Volume: 26, Issue:7 Topics: Animals; Blotting, Western; Bone Marrow Transplantation; Cell Proliferation; Cell Transformation, Neoplastic; Extracellular Signal-Regulated MAP Kinases; Mice; Mice, Inbred C57BL; Mutation; Myeloproliferative Disorders; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Signal Transduction; STAT5 Transcription Factor; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tyrosine	2012
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis. Neoplasia (New York, N.Y.), 2012, Volume: 14, Issue:6 Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Elongin; Female; Fusion Proteins, bcr-abl; Gene Expression; Humans; Janus Kinase 1; Janus Kinase 2; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Nude; Mutation; Phosphorylation; Protein Binding; Signal Transduction; STAT Transcription Factors; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription Factors; Tyrosine	2012
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood, 2012, Sep-27, Volume: 120, Issue:13 Topics: Animals; Apoptosis; Blotting, Western; Bone Marrow Transplantation; Cell Proliferation; Cell Transformation, Neoplastic; Class Ia Phosphatidylinositol 3-Kinase; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Immunoprecipitation; Integrases; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutation; Myeloproliferative Disorders; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-kit; Signal Transduction; Survival Rate; Tyrosine	2012
Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite. Marine drugs, 2012, Volume: 10, Issue:6 Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Antineoplastic Agents; Antioxidants; Cell Transformation, Neoplastic; Female; Lutein; Mice; Mice, Inbred ICR; Papilloma; Peroxynitrous Acid; Skin Neoplasms; Tyrosine; Xanthophylls	2012
Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice. Blood, 2012, Aug-30, Volume: 120, Issue:9 Topics: Animals; Apoptosis; Blotting, Western; Bone Marrow Cells; Bone Marrow Transplantation; Cell Line; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Enzyme Activation; Flow Cytometry; HEK293 Cells; Humans; Janus Kinase 2; Mice; Mice, Inbred BALB C; Mutation, Missense; Myeloproliferative Disorders; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Signal Transduction; STAT5 Transcription Factor; Tyrosine	2012
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood, 2012, Oct-18, Volume: 120, Issue:16 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Flow Cytometry; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Membrane Proteins; Mice; Mice, Knockout; Mutation; Phosphorylation; RNA, Small Interfering; Signal Transduction; src Homology Domains; Tandem Repeat Sequences; Tyrosine	2012
Characterization of the role of Fhit in suppression of DNA damage. Advances in biological regulation, 2013, Volume: 53, Issue:1 Topics: Acid Anhydride Hydrolases; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Comet Assay; DNA Damage; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Humans; Kidney; Mice; Neoplasm Proteins; Primary Cell Culture; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Proteins; Tyrosine	2013
Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases. Experimental hematology, 2013, Volume: 41, Issue:3 Topics: Animals; Apoptosis; Benzothiazoles; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chromones; Flow Cytometry; fms-Like Tyrosine Kinase 3; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Mice; Morpholines; Mutation; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Signal Transduction; Transfection; Tyrosine	2013
Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3. PloS one, 2012, Volume: 7, Issue:11 Topics: Animals; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; HEK293 Cells; HeLa Cells; Hep G2 Cells; HSP90 Heat-Shock Proteins; Humans; Luteolin; Mice; Neoplasms; Phosphorylation; Protein Binding; Proteolysis; Signal Transduction; STAT3 Transcription Factor; Tyrosine; Xenograft Model Antitumor Assays	2012
The unsulfated extracellular N-terminus of vGPCR reduces the tumorigenicity of hGRO-α in nude mice. Science China. Life sciences, 2013, Volume: 56, Issue:1 Topics: Animals; Autocrine Communication; Cell Transformation, Neoplastic; Chemokine CXCL1; HEK293 Cells; Herpesvirus 8, Human; Humans; Immunoblotting; Mice; Mice, Nude; Mutation; NIH 3T3 Cells; Protein Binding; Receptors, G-Protein-Coupled; Sulfates; Sulfur Radioisotopes; Transfection; Tyrosine; Viral Proteins	2013
PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation. Biochemical and biophysical research communications, 2013, Feb-22, Volume: 431, Issue:4 Topics: Catalysis; Cell Transformation, Neoplastic; Down-Regulation; Gene Knockdown Techniques; Humans; Neoplasm Proteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Proteolysis; Proto-Oncogene Proteins c-cbl; Tyrosine	2013
Critical role for Gab2 in transformation by BCR/ABL. Cancer cell, 2002, Volume: 1, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Benzamides; Cell Division; Cell Movement; Cell Transformation, Neoplastic; Erythroid Precursor Cells; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Guanosine Triphosphate; Helminth Proteins; Humans; Imatinib Mesylate; Immunoblotting; Leukemia, Lymphoid; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Precipitin Tests; Proteins; Pyrimidines; Signal Transduction; Tyrosine	2002
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation. Oncogene, 2002, Aug-22, Volume: 21, Issue:37 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neoplastic; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; GRB2 Adaptor Protein; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor II; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ets; Receptor, IGF Type 1; Receptor, trkC; Repressor Proteins; Signal Transduction; Tyrosine	2002
Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes. Journal of virology, 2002, Volume: 76, Issue:19 Topics: cdc25 Phosphatases; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; DNA; DNA-Binding Proteins; Enzyme Activation; G2 Phase; Hepatocytes; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; STAT3 Transcription Factor; Trans-Activators; Tyrosine; Viral Regulatory and Accessory Proteins	2002
Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc. British journal of cancer, 2002, Sep-09, Volume: 87, Issue:6 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Apoptosis; Binding Sites; Blotting, Western; Cell Transformation, Neoplastic; Cells, Cultured; DNA Fragmentation; Genes, Dominant; In Situ Nick-End Labeling; Luciferases; Mice; Mutation; Oncogene Proteins; Oncogene Proteins, Fusion; Plasmids; Precipitin Tests; Proteins; Receptor, trkA; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Thyroid Gland; Translocation, Genetic; Tyrosine	2002
Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation. Blood, 2003, Feb-01, Volume: 101, Issue:3 Topics: Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Enzyme Activation; Humans; Mice; Mutagenesis, Site-Directed; Mutation, Missense; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-kit; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine	2003
Nitric oxide pathways in human bladder carcinoma. The distribution of nitric oxide synthases, soluble guanylyl cyclase, cyclic guanosine monophosphate, and nitrotyrosine. Cancer, 2002, Dec-01, Volume: 95, Issue:11 Topics: Aged; Blotting, Western; Carcinoma; Cell Transformation, Neoplastic; Cyclic GMP; Free Radical Scavengers; Guanylate Cyclase; Humans; Immunohistochemistry; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Tyrosine; Urinary Bladder Neoplasms	2002
Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours. The Journal of pathology, 2003, Volume: 199, Issue:1 Topics: Blotting, Western; Cell Transformation, Neoplastic; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Humans; Interleukin-10; Lymphoma, Mantle-Cell; Neoplasm Proteins; Phosphorylation; Serine; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine	2003
Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proceedings of the National Academy of Sciences of the United States of America, 2003, Jun-24, Volume: 100, Issue:13 Topics: Adult; Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Benzamides; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Gene Deletion; Humans; Hypereosinophilic Syndrome; Imatinib Mesylate; Indoles; Male; Mice; Models, Chemical; Models, Genetic; Molecular Sequence Data; Peptides; Phthalazines; Piperazines; Precipitin Tests; Protein Structure, Tertiary; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Recombinant Fusion Proteins; Recurrence; Tyrosine	2003
Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. The Journal of biological chemistry, 2003, Sep-05, Volume: 278, Issue:36 Topics: 3T3 Cells; Alleles; Animals; Binding Sites; Catalysis; Cell Line; Cell Transformation, Neoplastic; DNA; Enzyme Activation; Enzyme Inhibitors; Genes, Reporter; GTP Phosphohydrolases; Guanine Nucleotide Exchange Factors; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Oncogene Proteins; Phosphorylation; Plasmids; Promoter Regions, Genetic; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-vav; Proto-Oncogene Proteins pp60(c-src); rac1 GTP-Binding Protein; Sulfonamides; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Time Factors; Transfection; Tyrosine; Vanadates	2003
Autoinhibition of Bcr-Abl through its SH3 domain. Molecular cell, 2003, Volume: 12, Issue:1 Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cell Transformation, Neoplastic; Enzyme Inhibitors; Eukaryotic Cells; Feedback, Physiological; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Models, Molecular; Mutation; Phosphorylation; Proline; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Tyrosine	2003
Vascular endothelial growth factor expression, beta-catenin tyrosine phosphorylation, and endothelial proliferative behavior: a pathway for transformation? Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:8 Topics: Antibodies, Blocking; Antigens, CD1; beta Catenin; Cell Division; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Endothelial Growth Factors; Endothelium, Vascular; Extracellular Matrix Proteins; Hemangioendothelioma; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Phosphorylation; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors	2003
Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. The Journal of biological chemistry, 2003, Nov-21, Volume: 278, Issue:47 Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Division; Cell Line, Transformed; Cell Movement; Cell Transformation, Neoplastic; Cellular Apoptosis Susceptibility Protein; Mass Spectrometry; Mice; Mice, Knockout; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphorylation; Tyrosine	2003
A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer research, 2003, Sep-01, Volume: 63, Issue:17 Topics: Animals; Apoptosis; B-Lymphocytes; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Indoles; Mice; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-met; Sulfonamides; Tyrosine	2003
v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts. The Journal of biological chemistry, 2003, Nov-28, Volume: 278, Issue:48 Topics: Actins; Alleles; Animals; Cell Adhesion; Cell Division; Cell Movement; Cell Separation; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Fibroblasts; Fibronectins; Flow Cytometry; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Genes, p53; Genes, src; Mice; Microscopy, Fluorescence; Oncogene Protein pp60(v-src); Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; RNA Interference; Signal Transduction; Temperature; Time Factors; Transfection; Tumor Suppressor Protein p53; Tyrosine; Wound Healing	2003
Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene, 2003, Oct-02, Volume: 22, Issue:43 Topics: Actins; Adaptor Proteins, Signal Transducing; Agar; Animals; Calmodulin-Binding Proteins; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cytoskeleton; ErbB Receptors; Fibroblasts; Glutathione Transferase; GRB2 Adaptor Protein; Ligands; Microscopy, Fluorescence; Models, Biological; Mutation; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Retroviridae; Signal Transduction; src Homology Domains; Tyrosine	2003
A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation. The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8 Topics: Agar; Amino Acid Sequence; Animals; Binding Sites; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Conserved Sequence; DNA-Binding Proteins; DNA, Complementary; Enzyme Activation; ETS Translocation Variant 6 Protein; Fibroblasts; Genes, Dominant; Genetic Vectors; Humans; Insulin Receptor Substrate Proteins; Mice; Mice, Nude; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; NIH 3T3 Cells; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-ets; Receptor, trkC; Repressor Proteins; Retroviridae; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Tyrosine	2004
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells. Oncogene, 2004, Mar-18, Volume: 23, Issue:12 Topics: Carcinoma, Papillary; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Collagen; Collagen Type I; DNA; Drug Combinations; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Laminin; Neoplasm Invasiveness; Osteopontin; Phenotype; Phosphorylation; Protein Structure, Tertiary; Proteoglycans; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sialoglycoproteins; Signal Transduction; Thyroid Neoplasms; Tyrosine	2004
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene, 2004, Apr-08, Volume: 23, Issue:15 Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Calcium; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; In Situ Nick-End Labeling; Janus Kinase 1; Luciferases; Mice; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tyrosine; Up-Regulation	2004
Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation. Cancer research, 2004, Mar-15, Volume: 64, Issue:6 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, fos; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Stress Fibers; Tyrosine	2004
A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Asparagine; Aspartic Acid; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Humans; Models, Molecular; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-met; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases	2004
Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts. The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28 Topics: Animals; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, ras; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mice; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proteins; ras Proteins; Retinoblastoma-Like Protein p130; Tyrosine	2004
A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase. Molecular and cellular biology, 2004, Volume: 24, Issue:11 Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Transformation, Neoplastic; GRB2 Adaptor Protein; Leukemia; Mice; Mitogen-Activated Protein Kinases; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proteins; Tyrosine	2004
Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase. Gut, 2004, Volume: 53, Issue:9 Topics: Adenocarcinoma; Adenoma; Animals; Cell Transformation, Neoplastic; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stomach; Stomach Neoplasms; Tyrosine	2004
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood, 2005, Feb-15, Volume: 105, Issue:4 Topics: Benzamides; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Deoxyglucose; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Jurkat Cells; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Monosaccharide Transport Proteins; Phloretin; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinases; Pyrimidines; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases; Tyrosine; Up-Regulation	2005
Transformation of madin-darby canine kidney epithelial cells by sheep retrovirus envelope proteins. Journal of virology, 2005, Volume: 79, Issue:2 Topics: Amino Acid Motifs; Animals; Cell Line; Cell Transformation, Neoplastic; Dogs; Jaagsiekte sheep retrovirus; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reactive Nitrogen Species; Retroviridae; Tyrosine; Viral Envelope Proteins	2005
Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation. Blood, 2005, Jul-01, Volume: 106, Issue:1 Topics: Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Regulation, Neoplastic; Mice; Mice, Transgenic; Multiple Myeloma; Mutagenesis, Site-Directed; Oncogene Proteins, Fusion; Phospholipase C gamma; Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 3; Receptors, Fibroblast Growth Factor; Signal Transduction; Type C Phospholipases; Tyrosine	2005
FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Developmental cell, 2005, Volume: 9, Issue:2 Topics: Animals; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Dynamins; Endocytosis; Extracellular Matrix; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Humans; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine	2005
The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis. Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:9 Topics: Animals; Apoptosis; Cell Differentiation; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cytoplasm; DNA Damage; Fibroblasts; Flow Cytometry; Immunoblotting; Microscopy, Fluorescence; Mutation; Myristic Acid; Neoplasm Proteins; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Retroviridae; src Homology Domains; Time Factors; Tyrosine; Ultraviolet Rays	2005
Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth. Journal of biomedical science, 2005, Volume: 12, Issue:4 Topics: Actins; Agar; Androstadienes; Animals; Anoikis; Binding Sites; Cell Adhesion; Cell Cycle; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Collagen; Crk-Associated Substrate Protein; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gelatin; Genes, Dominant; Immunoblotting; Immunoprecipitation; Laminin; Matrix Metalloproteinase 2; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Paxillin; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Talin; Time Factors; Transfection; Tyrosine; Vinculin; Wortmannin	2005
Inhibition of epidermal growth factor-induced cell transformation by tannins. Phytochemistry, 2005, Volume: 66, Issue:17 Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Tannins; Tyrosine	2005
4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as potent Src kinase inhibitors. Journal of medicinal chemistry, 2005, Sep-22, Volume: 48, Issue:19 Topics: Aniline Compounds; Animals; Antineoplastic Agents; Binding Sites; Biological Availability; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Fibroblasts; Humans; Mice; Models, Molecular; Nitriles; Phosphorylation; Quinolines; Rats; src-Family Kinases; Structure-Activity Relationship; Tyrosine; Xenograft Model Antitumor Assays	2005
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling. Oncogene, 2006, Jan-05, Volume: 25, Issue:1 Topics: Agar; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Binding Sites; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Gene Deletion; Insulin Receptor Substrate Proteins; Mice; Mutation; Neurons; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pol1 Transcription Initiation Complex Proteins; Receptor, IGF Type 1; Ribosomes; RNA; RNA, Ribosomal; Serine; Signal Transduction; Time Factors; Transfection; Tyrosine	2006
Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3. Oncogene, 2006, Feb-09, Volume: 25, Issue:6 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Janus Kinase 3; Mice; Mutation; Oncogenes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; Serine; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Tyrosine	2006
A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1. The Journal of biological chemistry, 2006, Jan-13, Volume: 281, Issue:2 Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Blotting, Western; Cell Membrane; Cell Proliferation; Cell Transformation, Neoplastic; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Humans; Immunoprecipitation; Ligands; Mice; Molecular Sequence Data; Mutation; Neovascularization, Pathologic; NIH 3T3 Cells; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Thymidine; Time Factors; Tyrosine; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2006
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Cancer research, 2005, Nov-15, Volume: 65, Issue:22 Topics: Amino Acid Sequence; Animals; c-Mer Tyrosine Kinase; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzyme Activation; HSP90 Heat-Shock Proteins; Humans; Male; Mice; Mice, Nude; Molecular Sequence Data; Oxidoreductases; Phosphorylation; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Tumor Suppressor Proteins; Tyrosine; Ubiquitin; WW Domain-Containing Oxidoreductase	2005
Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Cancer research, 2005, Dec-01, Volume: 65, Issue:23 Topics: Amino Acid Sequence; Animals; Apoptosis; Binding Sites; Caspase 3; Caspases; Cell Growth Processes; Cell Transformation, Neoplastic; Conserved Sequence; Enzyme Activation; Mice; Mice, Nude; Molecular Sequence Data; Oncogene Proteins; Phenylalanine; Phosphorylation; Point Mutation; Receptor Protein-Tyrosine Kinases; Sequence Alignment; Transfection; Tyrosine	2005
Cellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells. Oncogene, 2006, May-04, Volume: 25, Issue:19 Topics: Amino Acid Motifs; Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Epithelial Cells; Female; Fibroblasts; Flow Cytometry; Fluorescent Antibody Technique; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Male; Mammary Glands, Animal; Mice; NIH 3T3 Cells; Oncogene Proteins; Phenylalanine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; src-Family Kinases; Syk Kinase; Tyrosine	2006
Nitric oxide synthases are associated with bronchial dysplasia. Lung cancer (Amsterdam, Netherlands), 2006, Volume: 51, Issue:3 Topics: Aged; Analysis of Variance; Biomarkers; Bronchi; Bronchoscopy; Cell Transformation, Neoplastic; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Precancerous Conditions; Pulmonary Disease, Chronic Obstructive; Smoking; Tyrosine	2006
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. Blood, 2006, Aug-15, Volume: 108, Issue:4 Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Myeloproliferative Disorders; Protein Structure, Tertiary; Signal Transduction; STAT5 Transcription Factor; Tyrosine	2006
Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3. Oncogene, 2006, Nov-16, Volume: 25, Issue:54 Topics: alpha Catenin; Animals; Cell Adhesion; Cell Transformation, Neoplastic; Immunoblotting; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mice; Microscopy, Fluorescence; NIH 3T3 Cells; Phosphorylation; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Receptor, Fibroblast Growth Factor, Type 3; Tyrosine	2006
Viral immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling in cell transformation and cancer. Trends in cell biology, 2006, Volume: 16, Issue:8 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Intracellular Signaling Peptides and Proteins; Leukemia Virus, Bovine; Mammary Tumor Virus, Mouse; Protein-Tyrosine Kinases; Receptors, Immunologic; Sequence Alignment; Signal Transduction; src-Family Kinases; Syk Kinase; Tyrosine; Viral Envelope Proteins; Viral Proteins	2006
Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. The Journal of biological chemistry, 2006, Oct-13, Volume: 281, Issue:41 Topics: Binding Sites; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Humans; Mutation; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Signal Transduction; src Homology Domains; src-Family Kinases; Tyrosine	2006
Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. The Journal of biological chemistry, 2007, Feb-23, Volume: 282, Issue:8 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Membrane Permeability; Cell Transformation, Neoplastic; Humans; Microtubules; Mitochondria; Paclitaxel; Phosphorylation; Protein Processing, Post-Translational; Tubulin Modulators; Tyrosine	2007
Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene, 2007, Jul-12, Volume: 26, Issue:32 Topics: Adenocarcinoma; Antigens, Bacterial; Bacterial Proteins; beta Catenin; Cadherins; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Cytoplasm; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Intestinal Mucosa; Mucin-2; Mucins; Phosphorylation; Precancerous Conditions; Stomach Neoplasms; Transcriptional Activation; Tyrosine	2007
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell, 2007, Jan-26, Volume: 128, Issue:2 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Drug Resistance, Neoplasm; Feedback, Physiological; Female; Humans; Phosphorylation; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Tamoxifen; Tyrosine	2007
SRC utilizes Cas to block gap junctional communication mediated by connexin43. The Journal of biological chemistry, 2007, Jun-29, Volume: 282, Issue:26 Topics: Animals; Cell Communication; Cell Transformation, Neoplastic; Connexin 43; Crk-Associated Substrate Protein; Focal Adhesions; Gap Junctions; Mice; Mice, Knockout; Phosphorylation; RNA, Small Interfering; src-Family Kinases; Tumor Suppressor Proteins; Tyrosine	2007
The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Oncogene, 2007, Nov-15, Volume: 26, Issue:52 Topics: Adaptor Proteins, Signal Transducing; Animals; BALB 3T3 Cells; Breast Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Activation; Fibroblasts; Humans; Mice; Mitogen-Activated Protein Kinase 7; NIH 3T3 Cells; Phosphorylation; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT3 Transcription Factor; Tyrosine	2007
BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia. Cancer research, 2007, Jul-15, Volume: 67, Issue:14 Topics: Antigens, CD34; Benzamides; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Green Fluorescent Proteins; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcr; Pyrimidines; ras Proteins; Retroviridae; Tyrosine	2007
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer cell, 2007, Volume: 12, Issue:3 Topics: Apoptosis; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Multiple Myeloma; Phosphorylation; Receptor, Fibroblast Growth Factor, Type 3; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Tyrosine	2007
Tumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels. The American journal of pathology, 2007, Volume: 171, Issue:4 Topics: Animals; Apoptosis Regulatory Proteins; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Down-Regulation; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Interferons; NADH, NADPH Oxidoreductases; Phosphorylation; Rats; Retinoids; RNA, Small Interfering; src-Family Kinases; STAT3 Transcription Factor; Transfection; Tumor Suppressor Proteins; Tyrosine	2007
Phosphorylation of focal adhesion kinase at Tyrosine 407 negatively regulates Ras transformation of fibroblasts. Biochemical and biophysical research communications, 2007, Dec-28, Volume: 364, Issue:4 Topics: Animals; Binding Sites; Caco-2 Cells; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice; NIH 3T3 Cells; Phosphorylation; Protein Binding; ras Proteins; Rats; Tyrosine	2007
Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression. British journal of haematology, 2008, Volume: 140, Issue:1 Topics: Cell Communication; Cell Transformation, Neoplastic; Dimethyl Sulfoxide; Humans; Interleukin-4; Janus Kinase 1; Leukemia, Promyelocytic, Acute; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Phenotype; Phosphorylation; Receptors, Interleukin-4; Reverse Transcriptase Polymerase Chain Reaction; Suppressor of Cytokine Signaling Proteins; Tyrosine	2008
Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway. The Journal of biological chemistry, 2008, Feb-22, Volume: 283, Issue:8 Topics: Antiviral Agents; Butadienes; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Diterpenes; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gene Expression Regulation, Neoplastic; Hot Temperature; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitriles; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Tyrosine; Ubiquitin; Ubiquitination	2008
Abi1 gene silencing by short hairpin RNA impairs Bcr-Abl-induced cell adhesion and migration in vitro and leukemogenesis in vivo. Carcinogenesis, 2008, Volume: 29, Issue:9 Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Female; Flow Cytometry; Fusion Proteins, bcr-abl; Gene Silencing; Immunoprecipitation; Leukemia; Matrix Metalloproteinase 14; Mice; Mice, Inbred NOD; Mice, SCID; Microscopy, Fluorescence; Phosphorylation; Precursor Cells, B-Lymphoid; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; src-Family Kinases; Survival Rate; Tyrosine	2008
The major site of tyrosine phosphorylation in polyomavirus middle T antigen is not required for transformation. Journal of virology, 1984, Volume: 52, Issue:2 Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Antigens, Polyomavirus Transforming; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; DNA Restriction Enzymes; Mutation; Phosphorylation; Plasmids; Polyomavirus; Protein Kinases; Tyrosine; Viral Proteins	1984
Transformation by Rous sarcoma virus: a cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine. Cell, 1980, Volume: 21, Issue:3 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine; Viral Proteins	1980
Differences in mechanisms of transformation by independent feline sarcoma virus isolates. Journal of virology, 1981, Volume: 38, Issue:3 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epidermal Growth Factor; Mink; Phosphotyrosine; Protein Kinases; Rats; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins	1981
Snyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase. Journal of virology, 1981, Volume: 38, Issue:3 Topics: Binding Sites; Cell Transformation, Neoplastic; Cell Transformation, Viral; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma Viruses, Feline; Serine; Tyrosine; Viral Proteins	1981
Tyrosine phosphorylation and oncogenes. Nature, 1981, Jul-02, Volume: 292, Issue:5818 Topics: Animals; Cell Transformation, Neoplastic; Humans; Mice; Oncogenic Viruses; Phosphotyrosine; Protein Kinases; Rats; Sodium-Potassium-Exchanging ATPase; Tyrosine	1981
Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor. Science (New York, N.Y.), 1982, May-21, Volume: 216, Issue:4548 Topics: Abelson murine leukemia virus; Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; ErbB Receptors; Molecular Weight; Peptides; Phosphotyrosine; Rats; Receptors, Cell Surface; Transforming Growth Factors; Tyrosine	1982
Feline sarcoma virus-specific transformation-related proteins and protein kinase activity in tumor cells. Virology, 1983, Jan-30, Volume: 124, Issue:2 Topics: Animals; Cats; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Fibrosarcoma; Gene Products, gag; Melanoma; Mink; Peptides; Phosphotyrosine; Protein Kinases; Retroviridae; Retroviridae Proteins, Oncogenic; Sarcoma Viruses, Feline; Tumor Virus Infections; Tyrosine; Viral Proteins	1983
ts Transformation mutants of avian sarcoma virus PRCII: lack of strict correlation between transforming ability and properties of the P105-associated kinase. Virology, 1983, Volume: 125, Issue:1 Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibroblasts; Helper Viruses; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Kinases; Temperature; Tyrosine; Viral Proteins	1983
Transformation parameters and pp60src localization in cells infected with partial transformation mutants of Rous sarcoma virus. Molecular and cellular biology, 1983, Volume: 3, Issue:4 Topics: Animals; Cell Adhesion; Cell Compartmentation; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chickens; Contractile Proteins; Cytoskeleton; Fibronectins; Filamins; Microfilament Proteins; Muscle Proteins; Mutation; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Tyrosine; Vinculin; Viral Proteins	1983
Cultured cells transformed by Rous sarcoma virus: a genetically defined model and its phenotype. Progress in clinical and biological research, 1983, Volume: 115 Topics: Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Models, Biological; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Tyrosine	1983
Detection and localization of a phosphotyrosine-containing onc gene product in feline tumor cells. Haematology and blood transfusion, 1983, Volume: 28 Topics: Animals; Cats; Cell Transformation, Neoplastic; Melanoma; Mink; Neoplasm Proteins; Neoplasms, Experimental; Oncogenes; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma, Experimental; Tyrosine	1983
A mutation at the major phosphotyrosine in pp60v-src alters oncogenic potential. Virology, 1984, Jul-30, Volume: 136, Issue:2 Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Oncogene Protein pp60(v-src); Phenylalanine; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins	1984
Immunofluorescence localization of phosphotyrosine containing proteins in RSV-transformed mouse fibroblasts. Experimental cell research, 1984, Volume: 154, Issue:1 Topics: Animals; Antibodies; Antigen-Antibody Complex; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cross Reactions; Fibroblasts; Fluorescent Antibody Technique; Mice; Mice, Inbred BALB C; Phosphoproteins; Phosphotyrosine; Tyrosine	1984
The proteins of oncogenes. Scientific American, 1984, Volume: 251, Issue:2 Topics: Animals; Annexins; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA; Epidermal Growth Factor; ErbB Receptors; Guanosine Triphosphate; Humans; Membrane Proteins; Neoplasm Proteins; Nucleoproteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Protein Biosynthesis; Protein Kinases; Receptors, Cell Surface; Retroviridae; Tyrosine; Viral Proteins	1984
Preparation and characterization of antibodies to O-phosphotyrosine and their use for identification of phosphotyrosine-containing proteins. International journal of cancer, 1984, Dec-15, Volume: 34, Issue:6 Topics: Animals; Antibodies; Antibody Specificity; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; ErbB Receptors; Female; Fluorescent Antibody Technique; Mice; Phosphorus Radioisotopes; Phosphotyrosine; Proteins; Rabbits; Receptors, Cell Surface; Tyrosine	1984
Malignant transformation and protein phosphorylation. Nature, 1980, Jul-24, Volume: 286, Issue:5771 Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Protein Kinases; Sarcoma, Experimental; Tyrosine	1980
Abelson murine leukaemia virus transformation involves loss of epidermal growth factor-binding sites. Nature, 1980, Jul-31, Volume: 286, Issue:5772 Topics: Abelson murine leukemia virus; Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epidermal Growth Factor; Leukemia Virus, Murine; Mink; Peptides; Phosphoproteins; Protein Kinases; Rats; Receptors, Cell Surface; Tyrosine	1980
Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product. Cell, 1980, Volume: 21, Issue:3 Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Phosphoproteins; Phosphorylation; Tyrosine; Viral Proteins	1980
Gene products of McDonough feline sarcoma virus have an in vitro-associated protein kinase that phosphorylates tyrosine residues: lack of detection of this enzymatic activity in vivo. Journal of virology, 1981, Volume: 40, Issue:3 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Mice; Mink; Phosphorylation; Protein Kinases; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins	1981
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:4 Topics: Abelson murine leukemia virus; Alpharetrovirus; Amino Acid Sequence; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Immunoglobulin Heavy Chains; Peptides; Phosphorylation; Protein Kinases; Transforming Growth Factors; Tyrosine; Viral Proteins	1982
[Increase, in extracts of cancerous or transformed cells, of protein kinase activity phosphorylating tyrosine]. Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1982, Oct-11, Volume: 295, Issue:5 Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Embryo, Nonmammalian; Humans; Kinetics; Leukemia L1210; Mice; Phosphorylation; Protein Kinases; Quail; Sarcoma 180; Tyrosine	1982
Reduced synthesis of pp60src and expression of the transformation-related phenotype in interferon-treated Rous sarcoma virus-transformed rat cells. Molecular and cellular biology, 1983, Volume: 3, Issue:9 Topics: Actins; Animals; Avian Sarcoma Viruses; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Interferon Type I; Oncogene Protein pp60(v-src); Protein Kinases; Rats; Tyrosine; Viral Proteins	1983
Primary structure of v-raf: relatedness to the src family of oncogenes. Science (New York, N.Y.), 1984, Apr-20, Volume: 224, Issue:4646 Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Biological Evolution; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA Restriction Enzymes; Gene Products, gag; Genes, Viral; Mice; Oncogenes; Protein Biosynthesis; Protein Kinases; Protein-Tyrosine Kinases; Sarcoma Viruses, Murine; Transcription, Genetic; Tyrosine; Viral Proteins	1984
Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity. Cell, 1984, Volume: 37, Issue:2 Topics: Amino Acid Sequence; Animals; Antigens, Viral; Avian Sarcoma Viruses; Base Sequence; Cell Line; Cell Transformation, Neoplastic; DNA Restriction Enzymes; Gene Products, gag; Mutation; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Transfection; Tyrosine; Viral Proteins	1984
Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner. The Journal of biological chemistry, 1982, Dec-25, Volume: 257, Issue:24 Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Humans; Kinetics; Melanoma; Membrane Proteins; Mice; Peptides; Phosphorylation; Transforming Growth Factors; Tyrosine	1982
Inhibition of erythroid differentiation by stem cell factor in K562 cells expressing the c-kit gene. Experimental hematology, 1994, Volume: 22, Issue:1 Topics: Blotting, Northern; Cell Differentiation; Cell Transformation, Neoplastic; Cytarabine; DNA, Neoplasm; Erythroid Precursor Cells; Erythropoiesis; Flow Cytometry; Gene Expression Regulation, Neoplastic; Hematopoietic Cell Growth Factors; Hemin; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; RNA, Messenger; Stem Cell Factor; Transfection; Tumor Cells, Cultured; Tyrosine	1994
Role of oligomerization of the S13 Env-Sea oncoprotein in cell transformation. Journal of virology, 1994, Volume: 68, Issue:3 Topics: Alpharetrovirus; Animals; Blotting, Western; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Centrifugation, Density Gradient; Glycoproteins; Hexosaminidases; Oncogene Proteins, Viral; Oxidation-Reduction; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Conformation; Protein-Tyrosine Kinases; Rats; Tyrosine	1994
Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature, 1994, Jan-06, Volume: 367, Issue:6458 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; GRB2 Adaptor Protein; Molecular Sequence Data; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Proteins; Proto-Oncogene Proteins pp60(c-src); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine	1994
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. The Journal of biological chemistry, 1994, Mar-18, Volume: 269, Issue:11 Topics: Amino Acid Sequence; Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; Culture Media; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Tyrosine	1994
The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell, 1994, Apr-08, Volume: 77, Issue:1 Topics: 3T3 Cells; Animals; Cell Cycle; Cell Nucleus; Cell Transformation, Neoplastic; Gene Expression; Genes, abl; Genes, Dominant; Growth Inhibitors; Mice; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Transfection; Tyrosine	1994
The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor. Molecular biology of the cell, 1994, Volume: 5, Issue:1 Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Endocytosis; Mice; Mutagenesis, Site-Directed; Mutation; Oncogene Protein gp140(v-fms); Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rabbits; Rats; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; Tyrosine	1994
PDGF-independent activation of PDGF-beta receptors in NIH-3T3 cells transformed by c-met protooncogene. Experimental cell research, 1994, Volume: 212, Issue:2 Topics: 3T3 Cells; Animals; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; In Vitro Techniques; Mice; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Type C Phospholipases; Tyrosine	1994
Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Cancer letters, 1994, Nov-25, Volume: 87, Issue:1 Topics: 3T3 Cells; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chamomile; Culture Media; Cyclic AMP; Dose-Response Relationship, Drug; Flavonoids; Genes, ras; Genistein; Isoflavones; Kaempferols; Mice; Oils, Volatile; Phenotype; Phosphotyrosine; Plants, Medicinal; Protein-Tyrosine Kinases; Quercetin; Tyrosine	1994
Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Molecular and cellular biology, 1994, Volume: 14, Issue:12 Topics: 3T3 Cells; Alternative Splicing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; beta Catenin; Cadherins; Catenins; Cattle; Cell Adhesion Molecules; Cell Line; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Delta Catenin; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Trans-Activators; Tyrosine	1994
Modulatory effect of the transmembrane domain of the protein-tyrosine kinase encoded by oncogene ros: biological function and substrate interaction. Proceedings of the National Academy of Sciences of the United States of America, 1994, Nov-08, Volume: 91, Issue:23 Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; In Vitro Techniques; Membrane Glycoproteins; Mitogens; Mutagenesis, Site-Directed; Oncogene Proteins, Viral; Peptide Mapping; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship; Tyrosine	1994
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS. Molecular and cellular biology, 1995, Volume: 15, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Fusion Proteins, gag-onc; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Humans; Oncogene Proteins; Oncogenes; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Recombinant Proteins; Restriction Mapping; Sequence Deletion; Spodoptera; Transfection; Tyrosine	1995
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Molecular and cellular biology, 1995, Volume: 15, Issue:2 Topics: 3T3 Cells; Adenosine Triphosphate; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Chlorocebus aethiops; Electrophoresis, Gel, Two-Dimensional; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, Insulin; Recombinant Proteins; Transfection; Tyrosine	1995
Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation. Oncogene, 1995, Feb-02, Volume: 10, Issue:3 Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Mice; Mutation; Phosphoproteins; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Tyrosine	1995
Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Molecular and cellular biology, 1995, Volume: 15, Issue:3 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biotin; Blotting, Western; Cadherins; Cell Transformation, Neoplastic; Cytomegalovirus; Drosophila Proteins; Gene Expression Regulation, Neoplastic; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis, Site-Directed; Phosphotyrosine; Point Mutation; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Simian virus 40; Transfection; Tyrosine	1995
Hyperactive autocrine loop mediated by a NDF-related factor in neoplastic hamster embryo fibroblasts expressing an activated cph oncogene. Oncogene, 1995, Mar-02, Volume: 10, Issue:5 Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Fibroblasts; Glycoproteins; Mice; Neuregulins; Oncogenes; Phosphotyrosine; Receptor, ErbB-2; Tyrosine	1995
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity, 1995, Volume: 2, Issue:5 Topics: 3T3 Cells; Agammaglobulinaemia Tyrosine Kinase; Animals; B-Lymphocytes; Base Sequence; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression; Mice; Molecular Sequence Data; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine	1995
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene, 1995, May-04, Volume: 10, Issue:9 Topics: 3T3 Cells; Animals; Base Sequence; Breast Neoplasms; Cell Transformation, Neoplastic; DNA Primers; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, erbB; Glycoproteins; Ligands; Mice; Molecular Sequence Data; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Aggregation; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tyrosine	1995
Activation of a signal transduction pathway by osteopontin. Annals of the New York Academy of Sciences, 1995, Apr-21, Volume: 760 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Mice; Molecular Sequence Data; Oligopeptides; Osteopontin; Phosphorylation; Phosphotyrosine; Receptors, Cytoadhesin; Sialoglycoproteins; Signal Transduction; Tyrosine	1995
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science (New York, N.Y.), 1995, Jul-07, Volume: 269, Issue:5220 Topics: Animals; Base Sequence; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; DNA-Binding Proteins; Growth Inhibitors; Interferon-gamma; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine	1995
Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation. Cell, 1995, Jul-14, Volume: 82, Issue:1 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Transformation, Neoplastic; Fibroblasts; Fibrosarcoma; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Genes, ras; Hyaluronan Receptors; Lung; Mice; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Lymphocyte Homing; RNA, Antisense; Signal Transduction; Suppression, Genetic; Transfection; Tumor Cells, Cultured; Tyrosine	1995
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. The Journal of cell biology, 1995, Volume: 130, Issue:2 Topics: beta Catenin; Breast; Cadherins; Catenins; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Delta Catenin; Epithelial Cells; Epithelium; Female; Genes, ras; Humans; Intercellular Junctions; Phosphoproteins; Phosphorylation; Phosphotyrosine; Solubility; Trans-Activators; Tyrosine	1995
Adhesion-induced tyrosine phosphorylation of the p130 src substrate. Journal of cell science, 1995, Volume: 108 ( Pt 4) Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Transformation, Neoplastic; Embryo, Mammalian; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Microscopy, Fluorescence; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine	1995
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin. Cancer research, 1995, Sep-01, Volume: 55, Issue:17 Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; Emodin; Humans; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine	1995
Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. The Journal of biological chemistry, 1995, Sep-22, Volume: 270, Issue:38 Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Cells, Cultured; Cortactin; Crk-Associated Substrate Protein; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; In Vitro Techniques; Integrins; Mice; Microfilament Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Rats; Retinoblastoma-Like Protein p130; Tyrosine	1995
Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-src. Molecular biology of the cell, 1995, Volume: 6, Issue:8 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Alleles; Animals; Cell Adhesion Molecules; Cell Line, Transformed; Cell Transformation, Neoplastic; Chickens; Cortactin; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; GRB2 Adaptor Protein; GTPase-Activating Proteins; Microfilament Proteins; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Proteins; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine	1995
Two regions with differential growth-modulating activity in the N-terminal domain of ras GTPase-activating protein (p120GAP) src homology and Gly-Ala-Pro-rich regions. European journal of biochemistry, 1995, Sep-15, Volume: 232, Issue:3 Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Deoxyglucose; GTPase-Activating Proteins; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Proteins; ras GTPase-Activating Proteins; Rats; Sequence Homology, Amino Acid; Signal Transduction; src Homology Domains; Transfection; Tyrosine	1995
Structural requirements of the epidermal growth factor receptor for tyrosine phosphorylation of eps8 and eps15, substrates lacking Src SH2 homology domains. The Journal of biological chemistry, 1995, Jul-07, Volume: 270, Issue:27 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Calcium-Binding Proteins; Cell Transformation, Neoplastic; Cytoskeletal Proteins; DNA Mutational Analysis; ErbB Receptors; Genes, src; Humans; Intracellular Signaling Peptides and Proteins; Mice; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Deletion; Structure-Activity Relationship; Substrate Specificity; Tyrosine	1995
Suppression of RAS and MOS transformation by radicicol. Oncogene, 1995, Jul-06, Volume: 11, Issue:1 Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Genes, mos; Genes, ras; GTPase-Activating Proteins; Lactones; Macrolides; Mice; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tyrosine	1995
Loss of function effect of RET mutations causing Hirschsprung disease. Nature genetics, 1995, Volume: 10, Issue:1 Topics: 3T3 Cells; Animals; Base Sequence; Cell Differentiation; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinases; Drosophila Proteins; Exons; Genetic Complementation Test; HeLa Cells; Hirschsprung Disease; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; PC12 Cells; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Transfection; Tyrosine	1995
Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP. Journal of virology, 1995, Volume: 69, Issue:10 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; DNA Replication; Genes, fms; Glutathione Transferase; GTPase-Activating Proteins; Kinetics; Mice; Oncogene Protein gp140(v-fms); Oncogenes; Phenylalanine; Plasmids; Point Mutation; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Recombinant Fusion Proteins; Sarcoma Viruses, Feline; Thymidine; Transfection; Tyrosine	1995
Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. The Journal of biological chemistry, 1995, Sep-22, Volume: 270, Issue:38 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Base Sequence; Cell Transformation, Neoplastic; DNA Primers; Genes, Dominant; Humans; In Vitro Techniques; Mice; Mitosis; Molecular Sequence Data; Phosphorylation; Point Mutation; Proteins; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine	1995
Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor. Oncogene, 1995, Sep-07, Volume: 11, Issue:5 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; GRB2 Adaptor Protein; Humans; Ligands; Mice; Mice, Nude; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Polymerase Chain Reaction; Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; RNA, Messenger; Structure-Activity Relationship; Tyrosine; Vascular Endothelial Growth Factor Receptor-3	1995
Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A. Molecular and cellular biology, 1993, Volume: 13, Issue:1 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Transformation, Neoplastic; Cloning, Molecular; DNA; Drosophila Proteins; Gene Expression Regulation; Gene Rearrangement; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Thyroid Neoplasms; Tyrosine	1993
Repression of neu-induced clonogenicity by dimethylsulfoxide correlates with decreased levels of neu-encoded cell-surface p185 and changes in phosphotyrosine content of endogenous proteins. Cancer letters, 1993, Jan-15, Volume: 68, Issue:1 Topics: Animals; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Dimethyl Sulfoxide; Mice; Neoplasm Proteins; Oncogenes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Tyrosine	1993
Activation of a histone H1 kinase by tyrosine phosphorylation in v-src-transformed fibroblasts. The EMBO journal, 1993, Volume: 12, Issue:1 Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Activation; Fibroblasts; Fungal Proteins; Genes, src; Homeostasis; Immunoblotting; Kinetics; Molecular Sequence Data; Phosphotyrosine; Protamine Kinase; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Schizosaccharomyces pombe Proteins; Tyrosine	1993
Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1. The Journal of biological chemistry, 1993, Feb-05, Volume: 268, Issue:4 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Fibroblast Growth Factors; Genetic Vectors; In Vitro Techniques; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Metastasis; Neoplasms, Experimental; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Sorting Signals; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Structure-Activity Relationship; Transfection; Tyrosine	1993
En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America, 1993, Apr-15, Volume: 90, Issue:8 Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Enzyme Activation; Genes, abl; Humans; Mice; Moloney murine sarcoma virus; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Rats; Restriction Mapping; Signal Transduction; Transfection; Tyrosine	1993
Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase. Oncogene, 1993, Volume: 8, Issue:5 Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, fms; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; T-Lymphocytes; Transfection; Tyrosine	1993
Immortalization and neoplastic transformation of normal rat colon epithelium: an in vitro model of colonic neoplastic progression. Gastroenterology, 1993, Volume: 104, Issue:5 Topics: Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cytological Techniques; Gene Expression; Intestinal Mucosa; Phosphotyrosine; Rats; Reference Values; Simian virus 40; Tyrosine	1993
Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit. Proceedings of the National Academy of Sciences of the United States of America, 1993, May-01, Volume: 90, Issue:9 Topics: 3T3 Cells; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Electrophoresis, Polyacrylamide Gel; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Macromolecular Substances; Mice; Phosphorylation; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine	1993
A dominant negative Raf-1 mutant prevents v-Src-induced transformation. Biochemical and biophysical research communications, 1993, Apr-30, Volume: 192, Issue:2 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Diglycerides; Genes, Dominant; Mice; Mice, Inbred BALB C; Mutation; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tyrosine	1993
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. Biochemical and biophysical research communications, 1993, Jun-30, Volume: 193, Issue:3 Topics: Bronchi; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Doxorubicin; Emodin; Epithelium; Genes, ras; Humans; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine	1993
Downstream signal transduction defects that suppress transformation in two revertant cell lines expressing activated rat neu oncogene. The Journal of biological chemistry, 1993, Aug-25, Volume: 268, Issue:24 Topics: 3T3 Cells; Animals; Blotting, Southern; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; Ethyl Methanesulfonate; Mice; Mutagenesis; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Receptors, Cell Surface; Restriction Mapping; Signal Transduction; Tyrosine	1993
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Molecular and cellular biology, 1993, Volume: 13, Issue:9 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans; Cell Transformation, Neoplastic; Cloning, Molecular; ErbB Receptors; Gene Expression; Genes; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Oncogene Proteins; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Binding; Proteins; Receptors, Nerve Growth Factor; Recombinant Fusion Proteins; RNA, Messenger; Sequence Alignment; Tyrosine	1993
eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Molecular and cellular biology, 1993, Volume: 13, Issue:9 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Calcium-Binding Proteins; Cell Compartmentation; Cell Division; Cell Transformation, Neoplastic; Cloning, Molecular; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Sequence Alignment; Signal Transduction; Tyrosine	1993
Functional role of GTPase-activating protein in cell transformation by pp60v-src. Molecular and cellular biology, 1993, Volume: 13, Issue:11 Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Cell Transformation, Neoplastic; Gene Expression; Genes, ras; Genes, src; GTPase-Activating Proteins; Humans; Isoenzymes; Kinetics; Macromolecular Substances; Mice; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Biosynthesis; Proteins; ras GTPase-Activating Proteins; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine	1993
Morphological transformation, tumorigenicity and src-specific cytotoxic T-lymphocyte-mediated tumor immunity induced by murine 3T3 cells expressing src oncogenes encoding novel non-myristylated N-terminal domains. Oncogene, 1993, Volume: 8, Issue:11 Topics: 3T3 Cells; Animals; Base Sequence; Cell Transformation, Neoplastic; Genes, src; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasms, Experimental; Phosphotyrosine; T-Lymphocytes, Cytotoxic; Tyrosine	1993
Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Cancer research, 1995, May-01, Volume: 55, Issue:9 Topics: 3T3 Cells; Animals; Base Sequence; Cell Transformation, Neoplastic; Fibrosarcoma; Gene Expression; Humans; Li-Fraumeni Syndrome; Mice; Mice, Nude; Molecular Sequence Data; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Sarcoma, Experimental; Tumor Suppressor Protein p53; Tyrosine	1995
Tissue- and transformation-specific phosphotyrosyl proteins in v-erbB-transformed cells. Journal of virology, 1995, Volume: 69, Issue:6 Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Chick Embryo; Endothelium; Erythrocytes; Fibroblasts; Oncogene Proteins v-erbB; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Signal Transduction; Tyrosine	1995
Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1. The Journal of biological chemistry, 1995, May-26, Volume: 270, Issue:21 Topics: 3T3 Cells; Animals; Antigens, Polyomavirus Transforming; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA Mutational Analysis; Isoenzymes; Mice; Phospholipase C gamma; Phosphorylation; Polyomavirus; Precipitin Tests; Protein Binding; Signal Transduction; Structure-Activity Relationship; Type C Phospholipases; Tyrosine	1995
v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts. Oncogene, 1995, Jun-01, Volume: 10, Issue:11 Topics: Animals; Cell Adhesion Molecules; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hydrolysis; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Protein-Tyrosine Kinases; Tyrosine	1995
Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu. Oncogene, 1995, Jun-15, Volume: 10, Issue:12 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; GRB2 Adaptor Protein; GTPase-Activating Proteins; Mice; Phosphorylation; Proteins; ras GTPase-Activating Proteins; Receptor, ErbB-2; Substrate Specificity; Transfection; Type C Phospholipases; Tyrosine	1995
Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. The EMBO journal, 1995, Jun-15, Volume: 14, Issue:12 Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; DNA Mutational Analysis; Drosophila melanogaster; Drosophila Proteins; Enzyme Activation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Genes, Insect; Genes, Lethal; Janus Kinases; Larva; Lymphatic System; Molecular Sequence Data; Phosphorylation; Point Mutation; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Transcription Factors; Tyrosine	1995
A minor tyrosine phosphorylation site located within the CAIN domain plays a critical role in regulating tissue-specific transformation by erbB kinase. Journal of virology, 1995, Volume: 69, Issue:2 Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Molecular Sequence Data; Oncogene Proteins v-erbB; Organ Specificity; Phosphorylation; Point Mutation; Sarcoma, Experimental; Tyrosine	1995
Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells. Cancer research, 1995, Feb-01, Volume: 55, Issue:3 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Clone Cells; DNA; DNA Primers; Humans; Insulin-Like Growth Factor I; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Receptor, IGF Type 1; Recombinant Proteins; Transfection; Tyrosine	1995
Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. Oncogene, 1995, Jan-19, Volume: 10, Issue:2 Topics: 1-Phosphatidylinositol 4-Kinase; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Caseins; Cell Transformation, Neoplastic; Cells, Cultured; ErbB Receptors; GRB2 Adaptor Protein; Hepatocyte Growth Factor; Molecular Sequence Data; Mutagenesis; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Rats; Receptor Protein-Tyrosine Kinases; Tyrosine	1995
Increased detection of specific tyrosine phosphoproteins correlates with tumor progression of Abelson virus-infected lymphocytes. Leukemia, 1995, Volume: 9, Issue:1 Topics: 3T3 Cells; Abelson murine leukemia virus; Animals; Cell Transformation, Neoplastic; Culture Techniques; DNA-Binding Proteins; Female; Leukemia, Experimental; Lymphocytes; Mice; Mice, Inbred BALB C; Phosphoproteins; RNA-Binding Proteins; Tyrosine	1995
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. The EMBO journal, 1994, Oct-03, Volume: 13, Issue:19 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cytoplasm; Fusion Proteins, bcr-abl; HeLa Cells; Humans; Mice; Molecular Sequence Data; Mutation; Oncogene Protein v-cbl; Oncogene Proteins v-abl; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Retroviridae Proteins, Oncogenic; Tyrosine; Ubiquitin-Protein Ligases	1994
Deficiency of tyrosine phosphorylation in a Balb/c 3T3 cell variant hypersensitive to phorbol ester-induced cell transformation. Carcinogenesis, 1994, Volume: 15, Issue:6 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine	1994
A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science (New York, N.Y.), 1994, Aug-19, Volume: 265, Issue:5175 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Gene Expression; Humans; Kinetics; Mice; Mitosis; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine	1994
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. The EMBO journal, 1994, Aug-15, Volume: 13, Issue:16 Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Compartmentation; Cell Transformation, Neoplastic; Cloning, Molecular; Crk-Associated Substrate Protein; DNA, Complementary; Molecular Sequence Data; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Rats; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine	1994
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene, 1994, Volume: 9, Issue:10 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cell Transformation, Neoplastic; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine	1994
Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation. Oncogene, 1993, Volume: 8, Issue:5 Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Chick Embryo; Erythroblasts; Molecular Sequence Data; Mutation; Oncogene Proteins v-erbB; Oncogene Proteins, Viral; Phosphorylation; Rabbits; Retroviridae Proteins, Oncogenic; Structure-Activity Relationship; Tyrosine	1993
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. The EMBO journal, 1994, Feb-15, Volume: 13, Issue:4 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Cell Line, Transformed; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Oncogene Protein p21(ras); Phosphorylation; Proteins; Signal Transduction; Tyrosine	1994
Oncogenic activation of p59fyn tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528. The Journal of biological chemistry, 1994, Apr-08, Volume: 269, Issue:14 Topics: 3T3 Cells; Animals; Catalysis; Cell Transformation, Neoplastic; Enzyme Activation; Mice; Mutation; Phenylalanine; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Tyrosine	1994
Differential complementation of Bcr-Abl point mutants with c-Myc. Science (New York, N.Y.), 1994, Apr-15, Volume: 264, Issue:5157 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Gene Expression; Genes, abl; Genes, myc; Genetic Complementation Test; GRB2 Adaptor Protein; Molecular Sequence Data; Phosphorylation; Point Mutation; Proteins; Proto-Oncogene Proteins c-myc; Rats; Retroviridae; Signal Transduction; Transfection; Tyrosine	1994
[Analysis of the hepatocyte growth factor receptor in regeneration and oncogenesis of hepatocytes]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1994, Volume: 69, Issue:2 Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, Neoplastic; Humans; Liver; Liver Neoplasms; Liver Regeneration; Male; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Tyrosine	1994
The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Oncogene, 1994, Volume: 9, Issue:6 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Drosophila Proteins; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Oncogene Proteins; Phosphorylation; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine	1994
Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase. Oncogene, 1994, Volume: 9, Issue:7 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Gene Expression Regulation; Hepatocyte Growth Factor; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Substrate Specificity; Tyrosine	1994
Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants. The EMBO journal, 1993, Volume: 12, Issue:7 Topics: 3T3 Cells; Animals; Binding Sites; Cell Transformation, Neoplastic; Fluorescent Antibody Technique; Hormones; Kinetics; Mice; Phosphorylation; Protein Biosynthesis; Proto-Oncogene Proteins c-abl; Receptors, Estrogen; Recombinant Fusion Proteins; Tyrosine	1993
Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential. Journal of virology, 1993, Volume: 67, Issue:1 Topics: Animals; Avian Sarcoma Viruses; Base Sequence; Cell Transformation, Neoplastic; Chick Embryo; DNA Mutational Analysis; Fibroblasts; Gene Products, gag; Humans; Molecular Sequence Data; Neoplasm Proteins; Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Protein Conformation; Protein-Tyrosine Kinases; Receptors, Somatomedin; Recombinant Fusion Proteins; Structure-Activity Relationship; Tyrosine	1993
p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. The EMBO journal, 1993, Volume: 12, Issue:1 Topics: Animals; Avian Sarcoma Viruses; Benzoquinones; Cadherins; Cell Adhesion; Cell Aggregation; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; Fibroblasts; Lactams, Macrocyclic; Methionine; Oncogene Protein pp60(v-src); Phosphates; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine	1993
fgr proto-oncogene is expressed during terminal granulocytic differentiation of human promyelocytic HL60 cells. Experimental hematology, 1993, Volume: 21, Issue:2 Topics: Cell Transformation, Neoplastic; Dimethyl Sulfoxide; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Granulocytes; Humans; Leukemia, Promyelocytic, Acute; Phosphorylation; Precipitin Tests; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogenes; src-Family Kinases; Thymidine; Tritium; Tumor Cells, Cultured; Tyrosine	1993
The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation. Oncogene, 1993, Volume: 8, Issue:5 Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Base Sequence; Blood Proteins; Cell Transformation, Neoplastic; Cloning, Molecular; Cytoskeletal Proteins; ErbB Receptors; Histocompatibility Antigens; Humans; Membrane Proteins; Mice; Microfilament Proteins; Molecular Sequence Data; Neuropeptides; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Rabbits; Receptors, Platelet-Derived Growth Factor; Tyrosine	1993
Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl. Oncogene, 1993, Volume: 8, Issue:7 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Conserved Sequence; Gene Expression Regulation; Genes, abl; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Phenylalanine; Phosphorylation; Point Mutation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Structure-Activity Relationship; Tyrosine	1993
Identification of tyrosine 489 in the carboxy terminus of the Tpr-Met oncoprotein as a major site of autophosphorylation. Biochemistry, 1996, Jan-23, Volume: 35, Issue:3 Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Molecular Sequence Data; Nuclear Pore Complex Proteins; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Tyrosine	1996
Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor. The Journal of biological chemistry, 1996, Jan-05, Volume: 271, Issue:1 Topics: Animals; Cell Transformation, Neoplastic; Chick Embryo; Humans; Insulin Receptor Substrate Proteins; Isoenzymes; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Receptor, IGF Type 1; Signal Transduction; Type C Phospholipases; Tyrosine	1996
Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation. The EMBO journal, 1996, Jan-02, Volume: 15, Issue:1 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Enzyme Activation; ErbB Receptors; Humans; Inositol Phosphates; Isoenzymes; Mice; Molecular Sequence Data; Phospholipase C gamma; Phosphotyrosine; Protein Binding; Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Type C Phospholipases; Tyrosine	1996
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta. The Journal of biological chemistry, 1996, Mar-08, Volume: 271, Issue:10 Topics: Alleles; Aluminum Compounds; Animals; Animals, Newborn; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fluorides; Gene Expression; Genes, ras; GTP-Binding Proteins; Isoenzymes; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Signal Transduction; Spodoptera; Transfection; Transforming Growth Factor alpha; Tyrosine	1996
Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation. Molecular and cellular biology, 1996, Volume: 16, Issue:3 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Gene Transfer Techniques; Genes, ras; Mice; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tyrosine	1996
Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation. Oncogene, 1996, Feb-01, Volume: 12, Issue:3 Topics: 3T3 Cells; Animals; Blotting, Western; Cell Transformation, Neoplastic; Codon; Drosophila Proteins; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Mutagenesis, Site-Directed; Point Mutation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Transfection; Tyrosine	1996
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. The Journal of experimental medicine, 1996, Mar-01, Volume: 183, Issue:3 Topics: Base Sequence; Binding Sites; Cell Line; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Cytokines; DNA-Binding Proteins; Enzyme Activation; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; HL-60 Cells; Humans; Milk Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine	1996
A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins. The Journal of biological chemistry, 1996, Jul-26, Volume: 271, Issue:30 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Drosophila Proteins; Humans; Mice; Molecular Sequence Data; Multiple Endocrine Neoplasia; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Mutation; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine	1996
Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism. The EMBO journal, 1996, Jul-01, Volume: 15, Issue:13 Topics: ADP Ribose Transferases; Animals; Botulinum Toxins; Cell Division; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Hydrolysis; Phenotype; Phosphatidylinositols; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Receptors, Neurokinin-2; Tyrosine	1996
Control of adhesion-dependent cell survival by focal adhesion kinase. The Journal of cell biology, 1996, Volume: 134, Issue:3 Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; CD2 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Dogs; Enzyme Activation; Epithelial Cells; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kidney; Mice; Mice, Nude; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Recombinant Fusion Proteins; Tyrosine	1996
N-Nitroso-N-(3-keto-1,2-butanediol)-3'-nitrotyramine. A new genotoxic agent derived from the reaction of tyrosine and glucose in the presence of sodium nitrite. Archives of toxicology, 1995, Volume: 70, Issue:1 Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Female; Glucose; Maillard Reaction; Mice; Mutagens; Nitrosamines; Rats; Sepharose; Sodium Nitrite; Tetrazolium Salts; Tyramine; Tyrosine	1995
P210 Bcr-Abl interacts with the interleukin 3 receptor beta(c) subunit and constitutively induces its tyrosine phosphorylation. Cancer research, 1996, Aug-01, Volume: 56, Issue:15 Topics: Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macromolecular Substances; Neoplasm Proteins; Phosphorylation; Precipitin Tests; Receptors, Interleukin-3; Signal Transduction; Tyrosine	1996
p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. Oncogene, 1996, Sep-19, Volume: 13, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; Chemical Precipitation; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Fusion Proteins, bcr-abl; Gene Expression Regulation; GRB2 Adaptor Protein; Hematopoietic System; Immunoblotting; Interleukin-3; Mice; Phosphorylation; Proteins; Proto-Oncogene Proteins c-ets; Repressor Proteins; Signal Transduction; Transcription Factors; Transfection; Tyrosine	1996
Transformation of Rat-1 fibroblasts with the v-src oncogene induces inositol 1,4,5-trisphosphate 3-kinase expression. The Biochemical journal, 1996, Oct-01, Volume: 319 ( Pt 1) Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Electrophoresis, Polyacrylamide Gel; Epitopes; Fibroblasts; Gene Expression Regulation, Enzymologic; Genes, src; Oligopeptides; Oncogene Protein pp60(v-src); Peptides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; RNA, Messenger; Tyrosine	1996
BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia, 1996, Volume: 10, Issue:11 Topics: Animals; B-Lymphocytes; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA-Binding Proteins; Epitope Mapping; Epitopes; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Mice; Milk Proteins; Mutation; Phosphorylation; STAT1 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine	1996
A role for Ras in v-Crk transformation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1996, Volume: 7, Issue:11 Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Chick Embryo; Enzyme Activation; Fibroblasts; Genes, Dominant; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; Oncogene Protein v-crk; Oncogenes; Phosphorylation; Protein Prenylation; ras Proteins; Retroviridae Proteins, Oncogenic; Signal Transduction; src Homology Domains; Transfection; Tyrosine	1996
Correlation of constitutive activation of raf-1 with morphological transformation and abrogation of tyrosine phosphorylation of distinct sets of proteins in human squamous carcinoma cells. Molecular carcinogenesis, 1997, Volume: 18, Issue:1 Topics: Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cloning, Molecular; Head and Neck Neoplasms; Humans; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Transfection; Tumor Cells, Cultured; Tyrosine	1997
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. The EMBO journal, 1997, Feb-17, Volume: 16, Issue:4 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Cloning, Molecular; DNA, Complementary; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, fos; GRB2 Adaptor Protein; Humans; Mice; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; Proteins; RNA Splicing; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine	1997
Cell to substratum adhesion is involved in v-Src-induced cellular protein tyrosine phosphorylation: implication for the adhesion-regulated protein tyrosine phosphatase activity. Oncogene, 1997, Apr-17, Volume: 14, Issue:15 Topics: Actins; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Mice; Oncogene Protein pp60(v-src); Phosphorylation; Protein Tyrosine Phosphatases; Tyrosine	1997
Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line. Cancer research, 1997, May-15, Volume: 57, Issue:10 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cricetinae; DNA; Mesocricetus; Mice; Molecular Sequence Data; Mutation; Phenotype; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Precancerous Conditions; Proto-Oncogene Proteins pp60(c-src); Transfection; Tyrosine	1997
Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase. Oncogene, 1997, May-08, Volume: 14, Issue:18 Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Bone Marrow Cells; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rabbits; src Homology Domains; Tyrosine; Ubiquitin-Protein Ligases	1997
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene. Oncogene, 1997, May-08, Volume: 14, Issue:18 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Transformation, Neoplastic; Conserved Sequence; Epidermal Growth Factor; ErbB Receptors; Helminth Proteins; Mice; Mutation; Oncogene Protein v-cbl; Phosphorylation; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rabbits; Retroviridae Proteins, Oncogenic; Tyrosine; Ubiquitin-Protein Ligases	1997
Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals. Endocrinology, 1997, Volume: 138, Issue:7 Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Histidine; Humans; Insulin Receptor Substrate Proteins; Mice; Mitosis; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptor, IGF Type 1; src Homology Domains; Structure-Activity Relationship; Tyrosine	1997
Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells. Oncogene, 1997, Jun-19, Volume: 14, Issue:24 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibody Specificity; BRCA1 Protein; Breast Neoplasms; Cell Cycle; Cell Transformation, Neoplastic; Humans; Mice; Molecular Sequence Data; Phenotype; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine	1997
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Molecular and cellular biology, 1997, Volume: 17, Issue:8 Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; COS Cells; Enzyme Activation; Fibroblasts; Genes, ras; Genes, src; Molecular Sequence Data; Mutation; Peptide Fragments; Peptide Mapping; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Recombinant Fusion Proteins; Serine; Signal Transduction; Tyrosine	1997
Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1. The Journal of biological chemistry, 1997, Aug-08, Volume: 272, Issue:32 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Transformation, Neoplastic; ErbB Receptors; GRB2 Adaptor Protein; Mice; Molecular Weight; Oncogene Protein v-cbl; Oncogene Proteins, Fusion; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Rats; Rats, Inbred F344; Retroviridae Proteins, Oncogenic; Tyrosine	1997
The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation. The Journal of biological chemistry, 1997, Aug-15, Volume: 272, Issue:33 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Binding Sites; Cell Transformation, Neoplastic; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine	1997
v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions. Experimental cell research, 1997, Aug-01, Volume: 234, Issue:2 Topics: Actin Cytoskeleton; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Size; Cell Transformation, Neoplastic; Cytoskeletal Proteins; DNA-Binding Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fusion Proteins, gag-onc; Guanine Nucleotide Exchange Factors; Mutation; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Oncogene Protein pp60(v-src); Paxillin; Phosphoproteins; Phosphorylation; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; Repressor Proteins; RNA-Binding Proteins; Temperature; Transcription, Genetic; Tyrosine	1997
Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Molecular and cellular biology, 1997, Volume: 17, Issue:9 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Catalysis; Cell Transformation, Neoplastic; ErbB Receptors; GRB2 Adaptor Protein; Mice; Models, Biological; Mutagenesis; Phenylalanine; Phosphorylation; Proteins; ras Proteins; Receptor, ErbB-2; Signal Transduction; src Homology Domains; Tyrosine	1997
Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta. Cellular signalling, 1998, Volume: 10, Issue:4 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Differentiation; Cell Transformation, Neoplastic; COS Cells; DNA Mutational Analysis; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Initiation Factor-2; Guanine Nucleotide Exchange Factors; Humans; Mice; Mutation; Neurons; PC12 Cells; Phosphorylation; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-crk; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Transforming Growth Factor beta; Tyrosine; Ubiquitin-Protein Ligases	1998
v-fps causes transformation by inducing tyrosine phosphorylation and activation of the PDGFbeta receptor. Oncogene, 1998, May-07, Volume: 16, Issue:18 Topics: Amino Acid Sequence; Base Sequence; Cell Communication; Cell Line; Cell Transformation, Neoplastic; Fusion Proteins, gag-onc; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Sequence Homology, Amino Acid; Tyrosine	1998
Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America, 1998, Jun-23, Volume: 95, Issue:13 Topics: Animals; B-Lymphocytes; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Enzyme Activation; Gene Expression; Gene Rearrangement; Hematopoietic Stem Cells; Mice; Mice, Nude; Mice, Transgenic; Phosphorylation; src-Family Kinases; T-Lymphocytes; Transgenes; Tyrosine	1998
Absence of autophosphorylation site Y882 in the p185neu oncogene product correlates with a reduction of transforming potential. Oncogene, 1998, Jun-04, Volume: 16, Issue:22 Topics: Amino Acid Substitution; Animals; Binding Sites; Cell Division; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Mitogens; Mutagenesis, Site-Directed; Oncogenes; Phenylalanine; Phosphorylation; Rats; Receptor, ErbB-2; Tyrosine	1998
Identification of tyrosine phosphorylated adhesion proteins in human cancer cells. Hybridoma, 1998, Volume: 17, Issue:3 Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specificity; Breast Neoplasms; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Female; Humans; Mice; Phosphorylation; Tumor Cells, Cultured; Tyrosine	1998
Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation. Molecular and cellular biology, 1998, Volume: 18, Issue:10 Topics: 3T3 Cells; Animals; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression; Gene Products, gag; Isoenzymes; Mice; Mutation; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein-Tyrosine Kinases; Receptor, IGF Type 1; Signal Transduction; Tyrosine	1998
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. The EMBO journal, 1998, Nov-16, Volume: 17, Issue:22 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Fibroblasts; Gene Expression; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Mice; Oncogene Proteins; Phosphorylation; Proteins; Proto-Oncogene Proteins c-vav; Recombinant Proteins; Tyrosine	1998
Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor. Oncogene, 1998, Nov-26, Volume: 17, Issue:21 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Animals; Binding Sites; Cell Transformation, Neoplastic; Female; GRB2 Adaptor Protein; Mice; Mice, Nude; Models, Molecular; Mutagenesis, Site-Directed; Neoplasm Metastasis; Oncogenes; Phenylalanine; Point Mutation; Proteins; Proto-Oncogene Proteins c-met; Recombinant Fusion Proteins; Sequence Deletion; Signal Transduction; Structure-Activity Relationship; Tyrosine	1998
Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. Molecular medicine (Cambridge, Mass.), 1998, Volume: 4, Issue:10 Topics: 3T3 Cells; Actins; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Breast Neoplasms; Cell Membrane; Cell Transformation, Neoplastic; COS Cells; Cytoskeletal Proteins; Female; Homeodomain Proteins; Humans; LIM Domain Proteins; Mice; Microfilament Proteins; Molecular Sequence Data; Neoplasm Proteins; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); src Homology Domains; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine	1998
A transforming mutation enhances the activity of the c-Kit soluble tyrosine kinase domain. The Biochemical journal, 1999, Feb-15, Volume: 338 ( Pt 1) Topics: Animals; Antibody Affinity; Catalysis; Cell Fractionation; Cell Transformation, Neoplastic; Chromatography, Gel; Cytoplasm; Enzyme Activation; Genetic Vectors; Mast-Cell Sarcoma; Mice; Microspheres; Mutagenesis, Site-Directed; Oligopeptides; Peptide Fragments; Peptides; Phosphorylation; Pichia; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Solubility; Tumor Cells, Cultured; Tyrosine	1999
The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2. The Journal of biological chemistry, 1999, Mar-12, Volume: 274, Issue:11 Topics: Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Enzyme Activation; GRB2 Adaptor Protein; Intracellular Signaling Peptides and Proteins; Microinjections; Mutagenesis, Site-Directed; Oncogene Proteins, Viral; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Rats; Signal Transduction; Tyrosine	1999
Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling molecules. The Journal of biological chemistry, 1999, Apr-09, Volume: 274, Issue:15 Topics: Caseins; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA Fragmentation; DNA-Binding Proteins; Enzyme Activation; Humans; Janus Kinase 2; Milk Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Sequence Deletion; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Transcription, Genetic; Transfection; Tyrosine	1999
CRKL binding to BCR-ABL and BCR-ABL transformation. Leukemia & lymphoma, 1999, Volume: 33, Issue:1-2 Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cell Transformation, Neoplastic; Cells, Cultured; Fusion Proteins, bcr-abl; Humans; K562 Cells; Mutagenesis, Site-Directed; Nuclear Proteins; Phosphorylation; Proline; Protein Binding; Sequence Deletion; Transfection; Tyrosine	1999
The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism. Oncogene, 1999, Mar-18, Volume: 18, Issue:11 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Down-Regulation; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Mice; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine	1999
Inhibition of focal contact formation in cells transformed by p185neu. Molecular carcinogenesis, 1999, Volume: 25, Issue:2 Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, erbB-2; Integrins; Mice; Paxillin; Phosphoproteins; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine	1999
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. The EMBO journal, 1999, Jul-01, Volume: 18, Issue:13 Topics: Animals; Cell Division; Cell Size; Cell Survival; Cell Transformation, Neoplastic; Down-Regulation; Endocytosis; Gene Deletion; Lysosomes; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred C57BL; Peptide Hydrolases; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; ras Proteins; Receptor, Macrophage Colony-Stimulating Factor; Signal Transduction; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitins	1999
The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation. Molecular carcinogenesis, 1999, Volume: 26, Issue:1 Topics: Actins; Animals; Cell Adhesion; Cell Transformation, Neoplastic; Oncogene Protein pp60(v-src); Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rats; src-Family Kinases; Tyrosine; Ubiquitin-Protein Ligases	1999
The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells. Molecular and cellular biology, 1999, Volume: 19, Issue:10 Topics: Binding Sites; Cell Transformation, Neoplastic; DNA-Binding Proteins; Humans; Jurkat Cells; Models, Biological; Mutation; NFATC Transcription Factors; Nuclear Proteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptors, Antigen, T-Cell; Signal Transduction; src-Family Kinases; T-Lymphocytes; Transcription Factors; Tyrosine; Ubiquitin-Protein Ligases; ZAP-70 Protein-Tyrosine Kinase	1999
Sequential enhanced tyrosine phosphorylation during progressive malachite green induced malignant transformation of Syrian hamster embryo cells in culture is associated with no change in the activity levels of tyrosine phosphatases. Indian journal of experimental biology, 1999, Volume: 37, Issue:5 Topics: Animals; Blotting, Western; Cell Transformation, Neoplastic; Cricetinae; Electrophoresis, Polyacrylamide Gel; Humans; Mesocricetus; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rosaniline Dyes; Tyrosine	1999
Tyrosine phosphorylation and morphological transformation induced by four vanadium compounds on MC3T3E1 cells. Molecular and cellular biochemistry, 1999, Volume: 198, Issue:1-2 Topics: 3T3 Cells; Animals; Cell Division; Cell Transformation, Neoplastic; Insulin; Mice; Osteoblasts; Phosphorylation; Protein Tyrosine Phosphatases; Tyrosine; Vanadium	1999
MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential. Journal of cellular physiology, 1999, Volume: 181, Issue:3 Topics: 3T3 Cells; Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Mice; Models, Molecular; Mutagenesis, Site-Directed; Oncogenes; Phosphorylation; Point Mutation; Protein Conformation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Tyrosine; Up-Regulation	1999
Characterization of a novel member of the DOK family that binds and modulates Abl signaling. Molecular and cellular biology, 1999, Volume: 19, Issue:12 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA-Binding Proteins; DNA, Complementary; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oncogene Proteins v-abl; Phosphoproteins; Phosphorylation; Recombinant Fusion Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae; Subcellular Fractions; Tissue Distribution; Tyrosine	1999
Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin. FEBS letters, 1999, Oct-22, Volume: 460, Issue:1 Topics: Animals; Cell Adhesion; Cell Size; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Fibroblasts; Fibronectins; Isoenzymes; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Rats; Type C Phospholipases; Tyrosine	1999
Signaling in leukemia: which messenger to kill? The Journal of clinical investigation, 2000, Volume: 105, Issue:4 Topics: Cell Transformation, Neoplastic; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Humans; Leukemia, Myelomonocytic, Acute; Oncogene Proteins, Fusion; Phosphorylation; Proto-Oncogene Proteins c-ets; Receptors, Platelet-Derived Growth Factor; Repressor Proteins; Signal Transduction; Transcription Factors; Tyrosine	2000
Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581. The Journal of clinical investigation, 2000, Volume: 105, Issue:4 Topics: Animals; Cell Transformation, Neoplastic; Clone Cells; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Gene Rearrangement, T-Lymphocyte; Gene Transfer Techniques; Genetic Vectors; Leukemia, Myelomonocytic, Acute; Lymphoma, T-Cell; Mice; Mice, Inbred BALB C; Oncogene Proteins, Fusion; Proto-Oncogene Proteins c-ets; Receptors, Platelet-Derived Growth Factor; Repressor Proteins; Retroviridae; Signal Transduction; Syndrome; Tissue Transplantation; Transcription Factors; Tyrosine; Virus Integration	2000
The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl. Cancer research, 2000, Feb-15, Volume: 60, Issue:4 Topics: Cell Division; Cell Transformation, Neoplastic; Cytokines; Fusion Proteins, bcr-abl; Humans; Leukemia, Myeloid; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fes; Tyrosine	2000
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Molecular biology of the cell, 2000, Volume: 11, Issue:3 Topics: Animals; Cadherins; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Dogs; Down-Regulation; Epithelium; Half-Life; Kidney; MAP Kinase Kinase 1; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Occludin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; ras Proteins; Tight Junctions; Tyrosine; Zonula Occludens-1 Protein	2000
Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status. The Journal of biological chemistry, 2000, Mar-17, Volume: 275, Issue:11 Topics: Animals; Caveolin 1; Caveolins; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Isoforms; Pyrazoles; Pyrimidines; Recombinant Proteins; Signal Transduction; src-Family Kinases; Tyrosine	2000
Green tea compounds inhibit tyrosine phosphorylation of PDGF beta-receptor and transformation of A172 human glioblastoma. FEBS letters, 2000, Apr-07, Volume: 471, Issue:1 Topics: Catechin; Cell Transformation, Neoplastic; Glioblastoma; Humans; Male; Middle Aged; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Tea; Tyrosine	2000
Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. The EMBO journal, 2000, Apr-17, Volume: 19, Issue:8 Topics: 3T3 Cells; Animals; Bone Marrow; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 15; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Fibrosarcoma; Hematopoietic Stem Cells; Humans; Isoenzymes; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Mice; Milk Proteins; Muscle, Skeletal; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Proto-Oncogene Proteins c-ets; Receptor, trkC; Repressor Proteins; Signal Transduction; STAT5 Transcription Factor; Tissue Distribution; Trans-Activators; Transcription Factors; Translocation, Genetic; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine	2000
Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. Carcinogenesis, 2000, Volume: 21, Issue:5 Topics: 3T3 Cells; Animals; Base Sequence; Biological Transport; Cell Line; Cell Transformation, Neoplastic; DNA; Fibroblasts; Humans; Isoenzymes; Mice; Mutagenesis, Site-Directed; Phenylalanine; Protein Kinase C; Protein Kinase C-delta; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine	2000
Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia, 2000, Volume: 14, Issue:10 Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; DNA Primers; fms-Like Tyrosine Kinase 3; Humans; Mice; Mice, Inbred BALB C; Oncogene Proteins, Fusion; Phosphorylation; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Recombinant Proteins; Signal Transduction; Tyrosine	2000
Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells. Journal of immunology (Baltimore, Md. : 1950), 2000, Nov-01, Volume: 165, Issue:9 Topics: Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA-Binding Proteins; Enzyme Inhibitors; Growth Inhibitors; Human T-lymphotropic virus 1; Humans; Immunosuppressive Agents; Interleukin-15; Interleukin-2; Janus Kinase 3; Lymphocyte Activation; Milk Proteins; NF-kappa B; Nuclear Proteins; Phosphorylation; Phytohemagglutinins; Protein-Tyrosine Kinases; Serine; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrosine; Tyrphostins	2000
Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src. Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-27, Volume: 98, Issue:7 Topics: Actins; Animals; Cell Adhesion; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Cytoplasm; Cytoskeleton; Fibronectins; Focal Adhesions; Integrin beta1; Mice; Oncogene Protein pp60(v-src); Phosphorylation; Tyrosine	2001
Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor. Oncogene, 2001, Feb-15, Volume: 20, Issue:7 Topics: Actins; Adherens Junctions; Animals; Cadherins; Cell Differentiation; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Dogs; Epithelial Cells; Mesoderm; Morphogenesis; Mutation; Neoplasm Invasiveness; Phosphorylation; Receptor, ErbB-2; Signal Transduction; Tyrosine	2001
Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor. Molecular carcinogenesis, 2001, Volume: 30, Issue:4 Topics: Animals; Apoptosis; Blotting, Northern; Blotting, Western; Calcium; Cell Survival; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Connexins; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Hydrogen Peroxide; Immediate-Early Proteins; Liver; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Transcription Factors; Tyrosine	2001
UCS15A, a non-kinase inhibitor of Src signal transduction. Oncogene, 2001, Apr-19, Volume: 20, Issue:17 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Anti-Bacterial Agents; Benzaldehydes; Benzoquinones; Bone Resorption; Cell Transformation, Neoplastic; Cortactin; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Genes, src; Humans; Lactams, Macrocyclic; Lactones; Macrolides; Male; Mice; Microfilament Proteins; Organ Culture Techniques; Osteoclasts; Phosphorylation; Quinones; Rats; Rifabutin; RNA-Binding Proteins; Signal Transduction; src-Family Kinases; Tyrosine	2001
Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein. Oncogene, 2001, Jun-14, Volume: 20, Issue:27 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Amino Acid Substitution; Animals; Carcinoma, Papillary; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; COS Cells; Drosophila Proteins; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oncogenes; Protein Isoforms; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Thyroid Neoplasms; Transfection; Tyrosine	2001
Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor. Leukemia, 2001, Volume: 15, Issue:7 Topics: Animals; Apoptosis; Cell Line; Cell Transformation, Neoplastic; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Mice; Milk Proteins; Phosphorylation; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine; Tyrphostins	2001
Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Molecular and cellular biology, 2001, Volume: 21, Issue:17 Topics: 3T3 Cells; Animals; Axin Protein; beta Catenin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Transformation, Neoplastic; Cyclin D1; Cytoskeletal Proteins; Dogs; Glycogen Synthase Kinase 3; Mice; Mutagenesis, Site-Directed; Phosphorylation; Proteins; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-myc; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Repressor Proteins; Signal Transduction; TCF Transcription Factors; Trans-Activators; Transcription Factor 7-Like 2 Protein; Transcription Factors; Transcriptional Activation; Tyrosine	2001
Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins. The Journal of biological chemistry, 2001, Oct-19, Volume: 276, Issue:42 Topics: Amino Acid Motifs; Animals; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Fibroblasts; Intramolecular Transferases; Models, Biological; Mutagenesis, Site-Directed; Mutation; Peptides; Phosphorylation; Protein Binding; Protein Structure, Tertiary; ras Proteins; Rats; Receptor, ErbB-2; Signal Transduction; Tyrosine	2001
MEN2A-RET-induced cellular transformation by activation of STAT3. Oncogene, 2001, Aug-30, Volume: 20, Issue:38 Topics: 3T3 Cells; Animals; Binding Sites; Cell Division; Cell Line; Cell Transformation, Neoplastic; COS Cells; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drosophila Proteins; Enzyme Activation; Genes, Reporter; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Oncogenes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Serine; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine; Up-Regulation	2001
Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. Molecular biology of the cell, 2001, Volume: 12, Issue:10 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; CHO Cells; Cricetinae; DNA-Binding Proteins; Female; Fibroblasts; Humans; Janus Kinase 2; Kidney; Liver; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Ovary; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Inbred BUF; rhoA GTP-Binding Protein; Serine; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine	2001
Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry, 2001, Dec-04, Volume: 40, Issue:48 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Blotting, Western; Cell Transformation, Neoplastic; CSK Tyrosine-Protein Kinase; Dystrophin; Glutathione Transferase; Intramolecular Transferases; Mice; Oncogene Proteins; Peptide Fragments; Phosphorylation; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); src Homology Domains; src-Family Kinases; Transfection; Tyrosine	2001
Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice. Journal of cellular biochemistry, 2001, Volume: 83, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Catechin; Cell Aggregation; Cell Communication; Cell Movement; Cell Transformation, Neoplastic; Dacarbazine; Drug Screening Assays, Antitumor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Inhibitors; Injections, Intraperitoneal; Lung Neoplasms; Male; Matrix Metalloproteinases; Melanoma, Experimental; Mice; Neoplasm Transplantation; Phosphorylation; Protein-Tyrosine Kinases; Survival Rate; Tea; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine	2001
Enhanced sequential expression of G1/S cyclins during experimental epatocarcinogenesis and tyrosine phosphorylation. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2001, Volume: 20, Issue:3 Topics: Animals; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cyclin G; Cyclin G1; Cyclins; Gene Expression Regulation, Neoplastic; Liver Neoplasms; Male; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases; Rats; Rats, Wistar; Tyrosine	2001
Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. The Journal of biological chemistry, 2002, Apr-12, Volume: 277, Issue:15 Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, ras; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Phosphorylation; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine	2002
c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms. The Journal of biological chemistry, 2002, Apr-26, Volume: 277, Issue:17 Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Down-Regulation; Humans; Macrophage Colony-Stimulating Factor; Mice; Oncogene Protein gp140(v-fms); Phenotype; Point Mutation; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, Macrophage Colony-Stimulating Factor; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases	2002
Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity. Experimental cell research, 2002, Apr-15, Volume: 275, Issue:1 Topics: Alanine; Animals; Aspartic Acid; Catalysis; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Chick Embryo; ErbB Receptors; Fibroblasts; Gene Expression Regulation, Neoplastic; Ligands; Mutation; Oncogene Proteins v-erbB; Protein Kinases; Protein Structure, Tertiary; Signal Transduction; Tyrosine	2002
The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. Blood, 2002, Apr-15, Volume: 99, Issue:8 Topics: Animals; Base Sequence; Binding Sites; Bone Marrow Cells; Bone Marrow Transplantation; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Models, Animal; Mutation; Neoplasms, Experimental; Oncogene Proteins; Peptide Fragments; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Survival Analysis; Transduction, Genetic; Tumor Cells, Cultured; Tyrosine	2002
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer research, 2002, Apr-15, Volume: 62, Issue:8 Topics: 3T3 Cells; Amino Acid Substitution; Animals; Catalysis; Cell Transformation, Neoplastic; Drosophila Proteins; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis; Phenylalanine; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; src-Family Kinases; Transfection; Tyrosine	2002
Transformation of Ba/F3 cells and Rat-1 cells by ETV6/ARG. Oncogene, 2002, Jun-27, Volume: 21, Issue:28 Topics: Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Colony-Forming Units Assay; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Fibroblasts; Fusion Proteins, bcr-abl; Genes, abl; Humans; Interleukin-3; Leukemia, Myeloid; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ets; Rats; Recombinant Proteins; Repressor Proteins; Tumor Cells, Cultured; Tyrosine	2002
Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts. Carcinogenesis, 2002, Volume: 23, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoles; Biomarkers; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Fibroblasts; Genes, src; Glutathione; Isoindoles; Kinetics; Mitochondria; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Organoselenium Compounds; Rats; S-Nitrosoglutathione; Spermine; Tyrosine	2002
Alterations in SVT2 cell transfer RNAs in response to cell density and serum type. Biochimica et biophysica acta, 1975, Mar-10, Volume: 383, Issue:2 Topics: Animals; Asparagine; Aspartic Acid; Cattle; Cell Line; Cell Transformation, Neoplastic; Culture Media; Cyanogen Bromide; Histidine; Mice; Mice, Inbred BALB C; RNA, Transfer; RNA, Viral; Simian virus 40; Tyrosine	1975
Relation of cell type and cell density in tissue culture to the isoaccepting spectra of the nucleoside Q containing tRNAs: tRNATyr, tRNAHis, tRNAAsn and tRNAAsp. Nucleic acids research, 1978, Volume: 5, Issue:7 Topics: Asparagine; Aspartic Acid; Cell Line; Cell Transformation, Neoplastic; Contact Inhibition; Cyanogen Bromide; Guanosine; Histidine; RNA, Transfer; Simian virus 40; Tyrosine	1978
Stimulation of DNA synthesis by serum and amino acid in a rat neuroblastoma cell line. Experimental cell research, 1975, Oct-01, Volume: 95, Issue:1 Topics: Amino Acids; Blood; Cell Division; Cell Line; Cell Transformation, Neoplastic; Culture Media; Cystine; DNA; Glutamine; Tyrosine	1975
Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts. Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-01, Volume: 89, Issue:21 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Caveolin 1; Caveolins; Cell Membrane; Cell Transformation, Neoplastic; Chickens; Fibroblasts; Fluorescent Antibody Technique; Gene Expression; Gizzard, Avian; Membrane Proteins; Mice; Molecular Sequence Data; Muscle, Smooth; Oligodeoxyribonucleotides; Peptide Fragments; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Transfection; Tyrosine	1992
The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Molecular and cellular biology, 1992, Volume: 12, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Humans; Immunoblotting; Ligands; Mice; Mice, Inbred BALB C; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Oncogene Proteins; Phosphotyrosine; Rats; Retroviridae Proteins, Oncogenic; Sulfhydryl Compounds; Tyrosine; Vanadates	1992
Ornithine decarboxylase activity is critical for cell transformation. Nature, 1992, Nov-26, Volume: 360, Issue:6402 Topics: 3T3 Cells; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Transformation, Neoplastic; DNA; Eflornithine; Gene Expression; Genes, src; Humans; Mice; Molecular Sequence Data; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphotyrosine; Proto-Oncogene Mas; Rats; RNA, Antisense; Transfection; Tyrosine	1992
Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo. Molecular and cellular biology, 1992, Volume: 12, Issue:2 Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cloning, Molecular; DNA Mutational Analysis; Humans; Immunoblotting; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oncogene Proteins v-abl; Phosphotyrosine; Retroviridae; Tyrosine	1992
Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts. The Journal of cell biology, 1992, Volume: 117, Issue:2 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Endoplasmic Reticulum; Gene Expression; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Tyrosine Phosphatases; Transfection; Tyrosine	1992
Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells. Oncogene, 1992, Volume: 7, Issue:6 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Chick Embryo; Cloning, Molecular; DNA-Binding Proteins; Early Growth Response Protein 1; Fibroblasts; Gene Expression Regulation, Viral; Genes, src; Immediate-Early Proteins; Mice; Molecular Sequence Data; Muscles; Oligodeoxyribonucleotides; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Temperature; Transcription Factors; Transcription, Genetic; Tyrosine; Viral Proteins; Zinc Fingers	1992
Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation. Molecular and cellular biology, 1992, Volume: 12, Issue:12 Topics: 3T3 Cells; Animals; Animals, Newborn; Biological Transport; Calcium; Cell Differentiation; Cell Membrane; Cell Transformation, Neoplastic; DNA-Binding Proteins; Genes, ras; GTPase-Activating Proteins; Keratinocytes; Mice; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; RNA-Binding Proteins; Type C Phospholipases; Tyrosine	1992
Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol. Cancer research, 1992, Dec-15, Volume: 52, Issue:24 Topics: Animals; Antifungal Agents; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Friend murine leukemia virus; Lactones; Leukemia, Experimental; Macrolides; Oncogene Protein pp60(v-src); Phosphorylation; Rats; Tyrosine	1992
Multiple SH2-mediated interactions in v-src-transformed cells. Molecular and cellular biology, 1992, Volume: 12, Issue:3 Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Escherichia coli; GTPase-Activating Proteins; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; ras GTPase-Activating Proteins; Rats; Recombinant Fusion Proteins; Sequence Homology, Nucleic Acid; Tyrosine	1992
Establishment and characterization of a malignant melanocytic tumor cell line expressing the ret oncogene. Oncogene, 1992, Volume: 7, Issue:8 Topics: Animals; Blotting, Northern; Blotting, Western; Cell Transformation, Neoplastic; Drosophila Proteins; Melanoma, Experimental; Metallothionein; Mice; Mice, Nude; Mice, Transgenic; Neoplasm Transplantation; Oncogenes; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tumor Cells, Cultured; Tyrosine	1992
Glycoprotein tyrosine phosphorylation in Rous sarcoma virus-transformed chicken embryo fibroblasts. Molecular and cellular biology, 1990, Volume: 10, Issue:2 Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Fibroblasts; Glycoproteins; Kinetics; Mutation; Phosphorylation; Phosphotyrosine; Tyrosine	1990
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature, 1990, Jan-25, Volume: 343, Issue:6256 Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Fusion Proteins, gag-onc; GTPase-Activating Proteins; Immunosorbent Techniques; Mice; Mitosis; Molecular Weight; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Rats; Retroviridae; Tyrosine	1990
Serum independence of transcription from the promoter of an avian retrovirus in v-src-transformed cells is a primary, intracellular effect of increased tyrosine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:2 Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cycloheximide; Kinetics; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Temperature; Transfection; Tyrosine; Vanadates	1990
Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416. Oncogene research, 1990, Volume: 5, Issue:3 Topics: Animals; Annexins; Calcium-Binding Proteins; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Gene Expression; Genetic Variation; Immunoblotting; Mutation; Phenylalanine; Phosphopeptides; Phosphorylation; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Proto-Oncogenes; Tyrosine	1990
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:12 Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Cytosol; Mice; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Polyomavirus; Tyrosine	1990
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation. Journal of virology, 1990, Volume: 64, Issue:8 Topics: Animals; Avian Sarcoma Viruses; Base Sequence; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Oncogene Protein v-crk; Oncogenes; Phosphoproteins; Phosphotyrosine; Plasmids; Restriction Mapping; Retroviridae Proteins, Oncogenic; Tyrosine	1990
Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity. Journal of virology, 1990, Volume: 64, Issue:9 Topics: Abelson murine leukemia virus; Amino Acid Sequence; Amino Acids; Animals; Cell Line; Cell Transformation, Neoplastic; Kinetics; Leukemia Virus, Murine; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Temperature; Tyrosine	1990
A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity. Molecular and cellular biology, 1990, Volume: 10, Issue:10 Topics: Animals; Antibodies, Monoclonal; Cell Transformation, Neoplastic; Codon; DNA Mutational Analysis; Epitopes; Mice; Oncogene Proteins v-sis; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae Proteins, Oncogenic; Tyrosine	1990
Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene. Molecular and cellular biology, 1991, Volume: 11, Issue:1 Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine	1991
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. Proceedings of the National Academy of Sciences of the United States of America, 1991, Jan-15, Volume: 88, Issue:2 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Escherichia coli; Genes, abl; Genes, src; Mice; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins pp60(c-src); Restriction Mapping; Sequence Homology, Nucleic Acid; Tyrosine	1991
Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Molecular and cellular biology, 1991, Volume: 11, Issue:2 Topics: Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; ErbB Receptors; Humans; Kinetics; Molecular Weight; Moloney murine leukemia virus; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Phosphates; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins pp60(c-src); Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine	1991
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein. Molecular and cellular biology, 1991, Volume: 11, Issue:2 Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Genes, src; GTPase-Activating Proteins; Mutagenesis, Site-Directed; Peptide Mapping; Phosphopeptides; Phosphorylation; Proteins; Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; Rats; Transfection; Tyrosine	1991
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src. Genes & development, 1990, Volume: 4, Issue:12B Topics: Animals; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Gene Expression Regulation; Genes, src; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); RNA; Species Specificity; Transfection; Tyrosine	1990
Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins. Molecular and cellular biology, 1991, Volume: 11, Issue:3 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; DNA Mutational Analysis; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Retroviridae Proteins, Oncogenic; Structure-Activity Relationship; Tyrosine; Viral Fusion Proteins	1991
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation. Journal of cellular biochemistry, 1991, Volume: 45, Issue:1 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Gene Expression; Genes, ras; Humans; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tyrosine	1991
Tyrosine phosphorylation of a common 57-kDa protein in growth factor-stimulated and -transformed cells. The Journal of biological chemistry, 1991, Apr-15, Volume: 266, Issue:11 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Kinetics; Macrophage Colony-Stimulating Factor; Mice; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Tyrosine	1991
Thymic tumorigenesis induced by overexpression of p56lck. Proceedings of the National Academy of Sciences of the United States of America, 1991, May-01, Volume: 88, Issue:9 Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Gene Expression Regulation, Neoplastic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Transgenic; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; T-Lymphocyte Subsets; Thymoma; Thymus Neoplasms; Tyrosine	1991
Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src. Molecular carcinogenesis, 1991, Volume: 4, Issue:2 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Genes, src; Genetic Variation; GTPase-Activating Proteins; Molecular Weight; Mutagenesis; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Plasmids; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; Rats; Tyrosine	1991
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell, 1991, Jul-12, Volume: 66, Issue:1 Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Exons; Fusion Proteins, bcr-abl; Genes, abl; Genetic Variation; Humans; Insecta; Molecular Sequence Data; Oncogene Proteins; Oncogenes; Phosphotyrosine; Plasmids; Protein Biosynthesis; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transfection; Tyrosine	1991
Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events. The Journal of biological chemistry, 1991, Jul-25, Volume: 266, Issue:21 Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chemokine CCL2; Chemotactic Factors; Cyclic AMP; DNA; Gene Expression; Genes, ras; GTP-Binding Proteins; Mice; Phosphorylation; Phosphotransferases; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; rap GTP-Binding Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Tyrosine	1991
Oncogenic potential of erbB-2 in human mammary epithelial cells. Oncogene, 1991, Volume: 6, Issue:7 Topics: Animals; Breast; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; DNA; Epithelium; Gene Expression; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine	1991
Comparison of three methods for detecting tyrosine-phosphorylated proteins. Methods in enzymology, 1991, Volume: 201 Topics: Animals; Antigen-Antibody Complex; Autoradiography; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chromatography, Affinity; Fibroblasts; Glycoproteins; Immunoblotting; Methionine; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Radioisotope Dilution Technique; Sulfur Radioisotopes; Tyrosine	1991
PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate. Oncogene, 1991, Volume: 6, Issue:4 Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; In Vitro Techniques; Macrophage Colony-Stimulating Factor; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphorylation; Platelet-Derived Growth Factor; Tyrosine	1991
The ret oncogene products are membrane-bound glycoproteins phosphorylated on tyrosine residues in vivo. Biochemical and biophysical research communications, 1991, Nov-27, Volume: 181, Issue:1 Topics: 3T3 Cells; Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Drosophila Proteins; Membrane Glycoproteins; Mice; Mice, Transgenic; Oncogenes; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Tyrosine	1991
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:9 Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Immunoglobulin G; Immunoglobulin M; Oncogene Protein pp60(v-src); Oncogenes; Phosphoproteins; Protein-Tyrosine Kinases; Tyrosine	1990
PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell, 1990, Apr-06, Volume: 61, Issue:1 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Genes, ras; GTPase-Activating Proteins; Macromolecular Substances; Mice; Mutation; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinases; Proteins; ras GTPase-Activating Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tyrosine	1990
The action of v-src on gap junctional permeability is modulated by pH. The Journal of cell biology, 1990, Volume: 110, Issue:4 Topics: Animals; Avian Sarcoma Viruses; Calcium Channel Blockers; Cell Communication; Cell Line; Cell Membrane Permeability; Cell Transformation, Neoplastic; Cells, Cultured; Diglycerides; Gallic Acid; Gene Expression; Hydrogen-Ion Concentration; Intercellular Junctions; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Oncogene Protein pp60(v-src); Phosphorylation; Protein-Tyrosine Kinases; Temperature; Tyrosine	1990
Analysis of the role of the extracellular domain of the v-erbB oncogene in cellular transformation. Oncogene, 1990, Volume: 5, Issue:8 Topics: Alpharetrovirus; Animals; Avian Leukosis Virus; Cell Transformation, Neoplastic; Chick Embryo; Gene Products, gag; Membrane Glycoproteins; Oncogene Proteins, Viral; Oncogenes; Phosphorylation; Plasmids; Tyrosine	1990
Differentiating effect of L-tyrosine on the human melanoma cell line IIB-MEL-J. Experimental cell research, 1990, Volume: 188, Issue:1 Topics: Cell Adhesion; Cell Separation; Cell Transformation, Neoplastic; Centrifugation, Density Gradient; Humans; Lung Neoplasms; Melanins; Melanoma; Middle Aged; Tumor Cells, Cultured; Tyrosine	1990
Proton NMR studies of transforming and nontransforming H-ras p21 mutants. Biochemistry, 1990, Jan-16, Volume: 29, Issue:2 Topics: Base Sequence; Cell Transformation, Neoplastic; DNA; Guanosine Diphosphate; Guanosine Triphosphate; Magnesium; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Oncogene Protein p21(ras); Phenylalanine; Protein Conformation; Tyrosine	1990
Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins. Cell, 1985, Volume: 41, Issue:3 Topics: Animals; Cell Count; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Deoxyglucose; Kinetics; Mice; Moloney murine sarcoma virus; Phosphatidylinositols; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphotyrosine; Rats; Tyrosine; Vanadates; Vanadium; Zinc	1985
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (New York, N.Y.), 1986, Mar-21, Volume: 231, Issue:4744 Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Chickens; Fibroblasts; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Proto-Oncogenes; Retroviridae Proteins; Tyrosine	1986
Protein phosphorylation at tyrosine residues in v-abl transformed mouse lymphocytes and fibroblasts. International journal of cancer, 1986, Apr-15, Volume: 37, Issue:4 Topics: Abelson murine leukemia virus; Animals; Cell Transformation, Neoplastic; Chemical Precipitation; Fibroblasts; Lymphocytes; Mice; Mice, Inbred BALB C; Molecular Weight; Oncogene Proteins, Viral; Oncogenes; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Tyrosine	1986
Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases. European journal of biochemistry, 1986, Jul-15, Volume: 158, Issue:2 Topics: Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Growth Substances; Mice; Mice, Inbred BALB C; Molecular Weight; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae Proteins; Tyrosine	1986
Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein. Molecular and cellular biology, 1985, Volume: 5, Issue:12 Topics: Animals; Antibodies; Cell Transformation, Neoplastic; Chromatography, Affinity; Immunization; Oncogene Proteins, Viral; Phosphotyrosine; Tyrosine	1985
Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen. Molecular and cellular biology, 1986, Volume: 6, Issue:5 Topics: Amino Acids; Animals; Antibodies, Monoclonal; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Transformation, Neoplastic; Chick Embryo; Leukemia Virus, Murine; Mice; Oncogene Proteins, Viral; Peptide Mapping; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Trypsin; Tyrosine	1986
gp140v-fms molecules expressed at the surface of cells transformed by the McDonough strain of feline sarcoma virus are phosphorylated in tyrosine and serine. Molecular and cellular biology, 1986, Volume: 6, Issue:12 Topics: Animals; Cats; Cell Transformation, Neoplastic; Genes; Genes, Viral; Oncogene Protein gp140(v-fms); Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Retroviridae; Retroviridae Proteins; Serine; Tyrosine; Vanadates; Vanadium	1986
Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine. Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:5 Topics: Amino Acid Sequence; Animals; Antibodies; Cell Transformation, Neoplastic; Cells, Cultured; DNA Restriction Enzymes; Escherichia coli; Genes; Mice; Mutation; Oncogenes; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Temperature; Tyrosine	1987
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell, 1987, Sep-25, Volume: 50, Issue:7 Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Gene Expression Regulation; Mice; Mice, Inbred BALB C; Oncogene Protein gp140(v-fms); Oncogene Proteins v-sis; Oncogene Proteins, Viral; Oncogenes; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Polyomavirus; Protein-Tyrosine Kinases; Retroviridae Proteins; Simian virus 40; Substrate Specificity; Tyrosine	1987
Tyrosine phosphorylations in vivo associated with v-fms transformation. Molecular and cellular biology, 1988, Volume: 8, Issue:1 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Glycoproteins; Immunologic Techniques; Mice; Mink; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Retroviridae Proteins; Structure-Activity Relationship; Tyrosine	1988
Vanadate-treated baby hamster kidney fibroblasts show cytoskeleton and adhesion patterns similar to their Rous sarcoma virus-transformed counterparts. Journal of cellular biochemistry, 1988, Volume: 37, Issue:2 Topics: Actin Cytoskeleton; Animals; Avian Sarcoma Viruses; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cricetinae; Cytoskeleton; Fibroblasts; Kidney; Phenotype; Phosphoproteins; Phosphotyrosine; Tyrosine; Vanadates	1988
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner. Journal of virology, 1989, Volume: 63, Issue:1 Topics: Alleles; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; DNA, Viral; L Cells; Molecular Sequence Data; Mutation; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Substrate Specificity; Tyrosine	1989
Platelet-derived growth factor induces phosphorylation of a 64-kDa nuclear protein. The Journal of biological chemistry, 1989, Jan-15, Volume: 264, Issue:2 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Nuclear Proteins; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Subcellular Fractions; Sulfur Radioisotopes; Tyrosine	1989
Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1. Cancer research, 1989, Feb-15, Volume: 49, Issue:4 Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Benzoquinones; Cell Line; Cell Transformation, Neoplastic; Herbicides; Kinetics; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Retroviridae Proteins; Rifabutin; Thermodynamics; Tyrosine	1989
Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo. Molecular and cellular biology, 1988, Volume: 8, Issue:9 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Regulation; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine	1988
Inhibition of radiation-induced transformation of C3H/10T1/2 cells by carboxypeptidase inhibitor 1 and inhibitor II from potatoes. Carcinogenesis, 1989, Volume: 10, Issue:4 Topics: Animals; Aprotinin; Carboxypeptidases; Cell Transformation, Neoplastic; Cells, Cultured; Mice; Mice, Inbred C3H; Plant Proteins; Protease Inhibitors; Tyrosine	1989
Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis. Oncogene, 1989, Volume: 4, Issue:3 Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Mesocricetus; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Subcellular Fractions; Tyrosine	1989
Evidence that a phosphotyrosine-containing 120,000 Da protein from Rous sarcoma virus-infected cells is phosphorylated by pp60v-src. Oncogene research, 1989, Volume: 4, Issue:3 Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Electrophoresis, Polyacrylamide Gel; Molecular Weight; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine	1989
Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus. The Journal of biological chemistry, 1989, Dec-05, Volume: 264, Issue:34 Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Molecular Weight; Mutation; Myristic Acid; Myristic Acids; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tyrosine	1989
Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells. Journal of cell science, 1989, Volume: 94 ( Pt 1) Topics: Animals; Avian Sarcoma Viruses; Calcium-Binding Proteins; Cell Adhesion; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytoskeletal Proteins; Gelsolin; Gold; Immunohistochemistry; Microfilament Proteins; Microscopy, Electron; Oncogene Protein pp60(v-src); Phosphotyrosine; Rosette Formation; Tyrosine; Vinculin	1989
Transformation of NIH 3T3 fibroblasts by an activated form of p59hck. Molecular and cellular biology, 1989, Volume: 9, Issue:6 Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; DNA; Fibroblasts; Lysine; Mice; Moloney murine leukemia virus; Mutation; Phenotype; Phosphorylation; Protein-Tyrosine Kinases; Transfection; Tyrosine	1989
Disease tropism of c-erbB: effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:18 Topics: Animals; Avian Leukosis Virus; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chickens; Chromosome Deletion; ErbB Receptors; Fibroblasts; Molecular Sequence Data; Mutation; Proto-Oncogene Proteins; Proto-Oncogenes; Tyrosine; Virus Replication	1989
Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis. Cell, 1989, Oct-06, Volume: 59, Issue:1 Topics: Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Binding Sites; Cell Transformation, Neoplastic; Cell Transformation, Viral; Enzyme Activation; Mice; Mice, Inbred C3H; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Tumor Virus Infections; Tyrosine; Vanadates	1989
The trk oncogene abrogates growth factor requirements and transforms hematopoietic cells. Oncogene, 1989, Volume: 4, Issue:9 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Hematopoietic System; Humans; Interleukin-3; Mice; Neoplasm Transplantation; Phosphorylation; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Retroviridae; Tyrosine	1989
Tyrosine phosphorylation in signal transduction. Cold Spring Harbor symposia on quantitative biology, 1988, Volume: 53 Pt 1 Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Regulation; Immunoblotting; Mice; Mice, Inbred Strains; Peptide Mapping; Phosphorylation; Phosphotransferases; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine	1988
A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential. Cell, 1988, Dec-23, Volume: 55, Issue:6 Topics: Animals; Binding, Competitive; Cell Line; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Colony-Stimulating Factors; Humans; Mice; Mutation; Phenylalanine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, Macrophage Colony-Stimulating Factor; Tyrosine	1988
Residual transforming activity of PY1178T, a mutant lacking the principal in vitro tyrosine phosphorylation site, is not affected by removal of the secondary tyrosine phosphorylation site at residue 322. Virology, 1985, Volume: 143, Issue:2 Topics: Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Transformation, Neoplastic; Mutation; Oncogene Proteins, Viral; Phosphorylation; Polyomavirus; Protein Kinases; Protein-Tyrosine Kinases; Species Specificity; Tyrosine	1985
Phosphorylation of talin at tyrosine in Rous sarcoma virus-transformed cells. Molecular and cellular biology, 1987, Volume: 7, Issue:1 Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Cytoskeletal Proteins; Fibroblasts; Mutation; Peptide Mapping; Phosphorus Radioisotopes; Phosphorylation; Talin; Trypsin; Tyrosine	1987
Cytoskeletal organization, vinculin-phosphorylation, and fibronectin expression in transformed fibroblasts with different cell morphologies. Virology, 1986, Volume: 151, Issue:1 Topics: Actin Cytoskeleton; Animals; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Cytoskeleton; Fibroblasts; Fibronectins; Mice; Muscle Proteins; Oncogenes; Phosphorylation; Quail; Retroviridae; Tyrosine; Vinculin	1986
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell, 1987, Apr-10, Volume: 49, Issue:1 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Genes; Genetic Vectors; Mice; Mutation; Oncogene Protein pp60(v-src); Peptide Mapping; Phenylalanine; Phosphorylation; Protein-Tyrosine Kinases; Retroviridae; Retroviridae Proteins; Tyrosine	1987
Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:12 Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Genetic Vectors; Lymphocytes; Mice; Mutation; Oncogenes; Peptide Mapping; Phosphopeptides; Phosphorylation; Protein-Tyrosine Kinases; Trypsin; Tyrosine	1988
[Effect of 5-fluorouracil on protein metabolism of tumors and normal tissues in culture]. Zeitschrift fur Krebsforschung, 1970, Volume: 74, Issue:1 Topics: Adenocarcinoma; Animals; Autoradiography; Carcinoma, Basal Cell; Cell Line; Cell Transformation, Neoplastic; Culture Techniques; Depression, Chemical; Fluorouracil; Haplorhini; Humans; Kidney; Leucine; Neoplasm Proteins; Protein Biosynthesis; Simian virus 40; Skin; Tritium; Tyrosine	1970
Cytoplasmic changes during thioacetamide induced hepatocarcinogenesis in rats. British journal of cancer, 1971, Volume: 25, Issue:1 Topics: Adenosine Triphosphatases; Amides; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cytoplasm; Endoplasmic Reticulum; Enzyme Induction; Glucose-6-Phosphatase; Hydrocortisone; Liver Neoplasms; Microsomes, Liver; Neoplasms, Experimental; Rats; RNA, Messenger; Sulfhydryl Compounds; Tryptophan Oxygenase; Tyrosine; Tyrosine Transaminase	1971
The effect of a phenylalanine-tyrosine low diet on the growth and morphology of transplantable malignant melanomas of the Syrian golden hamster (Mesocricetus auratus). Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1973, Volume: 81, Issue:4 Topics: Animals; Cell Transformation, Neoplastic; Copper; Cricetinae; Diet; Hair; Melanins; Melanocytes; Melanoma; Microscopy, Electron; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Phenylalanine; Pigmentation Disorders; Protein Deficiency; Skin; Skin Neoplasms; Transplantation, Homologous; Tyrosine	1973
Transfer RNA patterns in livers of rats fed diets containing 3'-methyl-4-dimethylaminoazobenzene. Cancer research, 1970, Volume: 30, Issue:6 Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Chromatography; Female; Histidine; Leucine; Liver Diseases; Lysine; Methionine; Methylation; p-Dimethylaminoazobenzene; Phenylalanine; Precancerous Conditions; Rats; RNA, Transfer; Serine; Threonine; Tritium; Tyrosine; Valine	1970
Transfer RNA's in human leukemia. Journal of cellular physiology, 1969, Volume: 74, Issue:2 Topics: Amino Acid Sequence; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chromatography; Humans; Leucine; Leukemia; Lymphocyte Activation; Lymphocytes; Methylation; RNA, Neoplasm; RNA, Transfer; Time Factors; Tyrosine	1969
Inhibitors of chemical carcinogens as probes for molecular targets: DNA as decisive receptor for metabolite from N-hydroxy-N-2-fluorenylacetamide. Chemico-biological interactions, 1969, Volume: 1, Issue:2 Topics: Acetamides; Acetanilides; Animals; Carbon Isotopes; Cell Transformation, Neoplastic; Chloramphenicol; DNA; Drug Antagonism; Fluorenes; Guanine; Hydroxamic Acids; Indoles; Inosine; Liver; Male; Methionine; Proteins; Rats; Rats, Inbred Strains; RNA, Ribosomal; Stimulation, Chemical; Subcellular Fractions; Toluidines; Tryptophan; Tyrosine	1969