tyrosine has been researched along with Breast Neoplasms in 330 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (3.33) | 18.7374 |
| 1990's | 79 (23.94) | 18.2507 |
| 2000's | 130 (39.39) | 29.6817 |
| 2010's | 89 (26.97) | 24.3611 |
| 2020's | 21 (6.36) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, LQ; Gao, YH; Qu, SS; Yao, M | 1 |
| Sakurai, H; Suehiro, J; Wada, Y; Yamaga, T | 1 |
| Bai, P; Cai, R; Chu, B; Deng, Y; Kong, Q; Li, W; Liu, C; Ma, L; Qian, T; Sun, Y; Tian, R; Tian, Y; Wu, C | 1 |
| Aceto, N; Amante, RJ; Auf der Maur, P; Bentires-Alj, M; Bonenfant, D; Iesmantavicius, V; Richina, V; Sethi, A | 1 |
| Castillo-Sanchez, R; Cortes-Reynosa, P; Garcia-Hernandez, A; Lopez-Perez, M; Salazar, EP | 1 |
| Abdelwahed, M; Chavarria, H; Hacking, SM; Nasim, M; Wu, D | 1 |
| Emamzadeh, R; Jahanpanah, M; Nazari, M; Radmanesh, R; Yazdani, E | 1 |
| Anghel, R; Forsea, L; Gales, L; Georgescu, M; Mitrea, D; Mitrica, R; Serbanescu, L; Stanculescu, I; Stefanica, I; Trifanescu, O | 1 |
| Aryannejad, A; Asgari-Karchekani, S; Mousavi, SA; Shahsavarhaghighi, S; Tavangar, SM | 1 |
| Bilir, C; Deveci Ozkan, A; Guney Eskiler, G; Haciefendi, A; Kaleli, S; Kazan, N; Kocer, HB; Ozdemir, K; Ozen, M; Sahin, E; Yilmaz, F | 1 |
| Chan, LC; Chang, WC; Chen, MK; Chu, YY; Gao, Y; Hortobagyi, GN; Hsu, JL; Hung, MC; Jiang, Z; Lee, HH; Lee, S; Li, CF; Liu, C; Liu, J; Nie, L; Sood, AK; Wang, HL; Wang, SC; Wang, YN; Wei, Y; Westin, SN; Xia, W; Yam, C; Yamaguchi, H; Yang, L; Yu, D | 1 |
| Baharani, A; Lukong, KE; Mandapati, A; Ning, Z | 1 |
| Qiao, S; Wang, H; Wang, T | 1 |
| Kishi, H; Kobayashi, S; Maeda, N; Nagano, H; Tsunedomi, R; Xu, M; Zhang, Y; Zheng, H | 1 |
| Cheng, R; Deng, C; Fang, H; Gu, X; Sun, H; Zhao, X; Zhong, Z | 1 |
| Bagu, ET; Banks, CAS; Berg, JM; Dayebgadoh, G; Florens, L; Hattem, G; Kempf, CG; Lukong, KE; Miah, S; Napper, S; Ogunbolude, Y; Saraf, A; Sardiu, M; Tettey, TT; Washburn, MP | 1 |
| Bartel, K; Egusquiaguirre, SP; Frank, DA; Jiang, K; Liu, S; Nelson, EA; Nicolais, M; Saw, TY; Tošić, I; Walker, SR; Xiang, M | 1 |
| Järvinen, J; Kärkkäinen, J; Leppänen, J; Pocasap, P; Rautio, J; Timonen, J; Weerapreeyakul, N | 1 |
| Burguin, A; Diorio, C; Durocher, F; Furrer, D; Jacob, S; Ouellette, G | 1 |
| Aasen, T; Abdul Moin, NI; Abdul Wafi, S; Aboukameel, A; Abu-Bakar, N; Acharya, A; Ackermans, L; Adaramoye, O; Adarsh, KV; Adeosun, WA; Ahmad, NH; Ahmadi, F; Akanni, O; Akbar, M; Akbulak, RO; Akev, N; Akkaya, Ö; Al-Rashed, S; AlAbbad, S; Alabi, O; Alappat, BJ; Alcalá, S; Alcoutlabi, M; Aleppo, G; Alexander Ross, JB; Alexander, JH; Alexander, R; Alias, A; Alimba, C; Alken, FA; Allan, R; Alpers, M; Alsbou, EM; Amarasiri, SS; An, T; Anastasiadis, F; Anastassiadou, M; Anderson, KC; Andronikos, P; Anheyer, D; Annapurna, K; Anorlu, RI; Anten, MM; Anthopoulos, TD; Araujo-Castillo, RV; Aravamudhan, S; Arawwawala, LDAM; Arulsamy, N; Arunamata, A; Asghar, A; Asiri, AM; Aslanidou, T; Astrakhantseva, IV; Astutik, E; Attanayake, AP; Atwater, BD; Audureau, E; Augusto, S; Bakare, A; Banach, M; Bandelier, P; Banerjee, S; Barral, M; Bascuñán, J; Bates, FS; Bauer, NJC; Bayrak, BB; Beck, RW; Beckervordersantforth, J; Beeri, R; Begum, R; Beldi-Ferchiou, A; Bellingham, G; Ben-Tal, N; Bendib, I; Bergenstal, RM; Berger, MF; Bernasconi, G; Berry, S; Beuvon, F; Bi, WJ; Bi, Z; Bianconi, V; Bibi, I; Blank, BR; Bliemeister, E; Bobkowski, W; Bode, AM; Booth, CM; Bose, U; Boyd, K; Brancato, A; Brenmoehl, J; Brogi, E; Bronzo, P; Brooks, T; Brown, D; Brown, DN; Bruce, D; Buan, MEM; Bueno-Hernández, F; Bugielski, B; Bulavaitė, A; Buscagan, TM; Buxton, R; Caffaro, MM; Cai, Q; Cai, X; Cai, Y; Calhoun, P; Callander, N; Cambier, S; Camparo, P; Canales-Vargas, EJ; Canham, K; Cantu, J; Cao, J; Cao, JW; Cao, P; Cao, T; Cao, X; Caravella, BA; Carcadea, E; Carè, J; Carmichael, P; Carrasco Cabrera, L; Carteaux, G; Carvalho, PDS; Casarez, E; Cazorla, M; Celestrin, CP; Chakraborty, NK; Chan, B; Chandarlapaty, S; Chandgude, AL; Chang, CC; Chang, JH; Chang, X; Chang, Y; Chankhanittha, T; Chantanis, S; Chapovetsky, A; Chavan, S; Chen, B; Chen, D; Chen, F; Chen, G; Chen, H; Chen, J; Chen, K; Chen, KJ; Chen, KP; Chen, L; Chen, MA; Chen, Q; Chen, S; Chen, W; Chen, WF; Chen, X; Chen, Y; Cheng, D; Cheng, J; Cheng, Q; Cheon, GJ; Chiu, SC; Cho, CH; Cho, J; Choi, H; Choi, JS; Choi, YH; Christie, P; Chu, CH; Chu, Y; Chung, DH; Chung, F; Cline, JP; Cohen, A; Cohen, AD; Cohen, NJ; Comen, E; Compter, I; Cong, J; Cong, Z; Cooper, A; Cornud, F; Costa, C; Costa, S; Covey, A; Cowan, AM; Cramer, H; Cruz-Rivera, C; Cui, J; Cui, M; Cui, Y; Cui, YH; Culquichicón, C; Cushman, T; D'Auria, SJ; da Silva, J; Dalgediene, I; Danenberg, HD; Das, S; Dasgupta, K; Daubit, IM; de Oliveira, PD; de Prost, N; De Ruysscher, D; Dearman, K; Decato, D; Delfau-Larue, MH; Deng, L; Dhakate, SR; Dharuman, V; Di Costanzo, N; Dickler, MN; Dinehart, EE; Ding, D; Dinh, TK; Divya, KP; Djifack Tadongfack, T; Do, T; Domínguez-Roldan, R; Domínguez-Zambrano, E; Dömling, A; Donato, MD; Dong, JH; Dong, W; Dong, X; Dong, XR; Dong, Y; Dong, Z; Downs, M; Drutskaya, MS; Du, B; Du, F; Du, H; Du, L; Du, X; Duan, Z; Duangthip, D; Dunstand-Guzmán, E; Duong, F; Eckert, DJ; Edelhäuser, BAH; Eekers, DBP; Efendi, F; Efraimidis, P; Ehrenberg, H; Ehsanbakhsh, Z; Eickholt, C; Eksterowicz, J; El Mobadder, M; El-Araby, IE; El-Magd, MA; El-Tarabany, MS; Elgorban, AM; Engelmann, D; English, KL; Esfandiari, H; Eslami, B; Espinosa-Cuevas, A; Eswara, S; Faber, E; Fan, XH; Fan, Y; Fang, J; Fang, Z; Fantin, VR; Fei, P; Feng, G; Feng, H; Feng, J; Feng, X; Feng, XJ; Fennell, TR; Fernández-Moreira, V; Ferraz, ABF; Ferreras, KN; Flores, K; Flores-Pérez, I; Flox, C; Fluharty, FL; Fokouong Tchoffo, E; Folefack, GO; Foroutan, T; Fort, D; Fourati, S; Fousas, S; Frapard, T; Freguia, S; Friedman, DJ; Friedman, LS; Fu, D; Fu, Q; Fu, Y; Fujinami, S; Furihata, K; Gal, RL; Gan, H; Gao, C; Gao, F; Gao, R; Gao, SS; Gao, W; Gao, XC; Gao, Y; Gao, Z; Garozi, L; Ge, J; Georgiopoulos, A; Gerakiou, K; Ghazimirsaeed, SM; Ghazimirsaeed, ST; Gimeno, MC; Gjestad, R; Glurich, I; Goetchius, E; Goland, S; Goldstein, S; Gonçalves, CM; Gonçalves, H; Gong, Q; Gonzalez, D; Goplen, FK; Gorshkova, EN; Gotsman, I; Govindasamy, V; Granger, CB; Greco, L; Grigoriadou-Skouta, E; Grigoropoulos, P; Grivicich, I; Gromov, NV; Gruber, S; Grytczuk, M; Grzech-Leśniak, K; Gu, L; Gu, S; Gu, Z; Guadagnini, D; Guan, H; Guilliams, M; Guo, J; Guo, L; Gupta, A; Gupta, SK; Gurzu, S; Gutleb, AC; Haban, A; Hablitz, JJ; Hadisuyatmana, S; Hahn, S; Haiges, R; Hallal-Calleros, C; Hamed, M; Hammad, N; Hammer, N; Han, C; Hao, Y; Harnett, J; Has, EMM; Hassanpour, K; Hatzopoulos, D; Hawaldar, R; He, X; He, Y; He, YY; He, Z; Heberman, D; Heckl, D; Hegde, H; Henson, MA; Hernández-Velázquez, VM; Herrera, E; Hijazi, Z; Hirayama, K; Hirth, JM; Hoeben, A; Hohnloser, SH; Hong, M; Hood, K; Hoplock, LB; Hopman, WM; Horlbogen, LM; Hossein Rashidi, B; Hou, G; Hou, H; Hou, J; Hou, Y; Hu, J; Hu, W; Hu, X; Hua, W; Huang, G; Huang, H; Huang, J; Huang, T; Huang, W; Huang, Y; Huang, YD; Huang, Z; Hudis, CA; Hue, S; Huo, J; Hussain, M; Hvas, AM; Ichii, T; Ide Zeuna, J; Ilyas, S; Inoue, T; Iranzo, A; Irfan, M; Iwasa, Y; Iwashita, Y; Izgorodina, EI; J R, A; Jaber, WA; Jaborek, JR; Jacobus, SJ; Jadeja, SD; Jafarabadi, M; Jalan, D; Jamil, MI; Jarrah, S; Jarvis, D; Jayatilaka, KAPW; Jemal-Turki, A; Jeon, YK; Jeong, N; Jeong, SH; Jeong, SY; Jermy, M; Jhaveri, K; Ji, H; Ji, K; Ji, RY; Jiang, F; Jiang, J; Jiang, X; Jiang, Y; Jiao, Q; Jilani, K; Jiménez-Guerrero, P; Jin, L; Jo, YH; Johnson, JG; Johnson, ML; Jones, WS; Jose, S; Jularic, M; Jung, I; Jung, YJ; Jungen, C; Junttila, MR; Kache, S; Kahanovitch, U; Kalantzi, KI; Kallio, T; Kamnoedboon, P; Kang, CH; Kang, H; Kang, J; Kang, KW; Kapoor, P; Karmakar, D; Kartalis, A; Kauranen, P; Kazocina, A; Keikha, F; Keltai, M; Kershaw, SV; Kettani, M; Khalvati, S; Khandhar, S; Khosla, N; Kiely, CJ; Kim, CC; Kim, H; Kim, MJ; Kim, Y; Kim, YH; Kim, YT; Kimoto, E; Kiyu, A; Klatt, N; Kobayashi, M; Koh, J; Köhler, R; Kondadasula, SV; Kong, H; Kong, W; Kong, X; Kotidis, A; Kotwal, A; Kouvari, M; Kozhinov, AN; Kruger, D; Kuang, S; Kuang, Y; Kubota, M; Kuklik, P; Kumar, P; Kumar, SK; Kuo, YF; Kurup, SP; Kusuhara, H; Kuswanto, H; Lacouture, ME; Lambin, P; Lang, CC; Langroudi, FH; Lanman, RB; Larsen, OH; Laskin, J; Le, VH; Leach, M; Lee, BG; Lee, DF; Lee, DS; Lee, HJ; Lee, SB; Lee, YA; Lei, Y; Lekashvili, O; Lelj, F; Lemin, AS; Lemoine, J; Leuschner, R; Li, B; Li, BT; Li, C; Li, D; Li, F; Li, G; Li, H; Li, HW; Li, J; Li, M; Li, P; Li, Q; Li, S; Li, W; Li, X; Li, XY; Li, Y; Li, Z; Lian, Y; Liang, C; Liao, J; Liao, W; Liao, Y; Lin, D; Lin, W; Lin, YL; Lindbäck, J; Lindsay, AP; Ling, J; Linser, PJ; Liu, C; Liu, H; Liu, JJ; Liu, L; Liu, Q; Liu, SF; Liu, X; Liu, Y; Liu, Z; Liu, ZM; Lo Sterzo, C; Lo, ECM; Lobchuk, MM; Lodge, TP; Logotheti, S; Lonial, S; Lopes, G; Lopes, RD; Lopez, J; Lopez, SA; López-Santos, AL; López-Sendón, JL; Loring, Z; Louis, C; Lovita, AND; Lu, DZ; Lu, H; Lu, J; Lu, K; Lu, TT; Lu, Y; Luengo, A; Lum, LG; Luna, JM; Luo, L; Luo, R; Luo, T; Luo, X; Luo, Z; Lv, B; Lymperopoulos, N; Lyras, A; Lyu, Y; M Kannan, A; Ma, H; Ma, M; Ma, Q; Ma, S; Ma, WY; Ma, Y; Maalouf, E; Machado, FA; Maeda, K; Magrans, JO; Maharani, A; Maia, G; Mainwaring, RD; Maji, TK; Majumdar, K; Mannarino, MR; Mansuri, MS; Marinescu, SC; Markatos, G; Marquardt, S; Marraiki, N; Martens, C; Martínez, TJ; Marumo, K; Maruyama, H; Marwani, HM; Marzo, I; Masrati, G; Matamba, P; Mathialagan, S; Matys, J; Mayatra, JM; Mboua, PC; McArthur, T; McCrimmon, RJ; McIntosh, S; McSpadden, S; Medina-Campos, ON; Medvedovsky, AT; Mei, Z; Mekontso-Dessap, A; Menezes, AMB; Meng, J; Meng, P; Meng, Y; Menter, A; Mets, MB; Mets-Halgrimson, R; Metzger, T; Metzler-Nolte, N; Meyer, C; Mi, Y; Michailoviene, V; Mikrogeorgiou, A; Militz, H; Miller Iii, TF; Minarowska, A; Mir, S; Miron, I; Miyake, T; Moayer, F; Modi, S; Moeller, SJ; Mohamad, MN; Mohammed, EHM; Mokhonov, VV; Mondal, A; Moore, J; Moravcova, M; Mordi, IR; Mordi, NA; Mortensen, NP; Moscariello, C; Moser, J; Moynahan, ME; Mu, J; Mu, W; Mudduwa, LKB; Mukherjee, S; Mukhtar, A; Mulkey, DK; Murr, N; Mushtaq, Z; Muthuswamy, N; Mutlu, O; Muto, C; Myroforou, I; Na, KJ; Nabi, M; Nagornov, KO; Nagy, RJ; Naik, A; Nakajima, K; Nam, KT; Nam, YW; Namburath, M; Nammour, S; Namour, A; Namour, M; Nanan, S; Natsume, H; Nave, S; Naveed, A; Nazir, H; Ndubaku, C; Nedospasov, SA; Neradilek, MB; Newcomb, C; Nguépy Keubo, FR; Nguyen, M; Ning, J; Ning, Q; Noguchi, S; Nordahl, SHG; Nordfalk, KF; Norton, L; Noupoue, EM; Nouri, SS; Nowak, JK; Núñez, K; Oakes, K; Odegaard, JI; Ogorodnikova, OL; Ogunsuyi, O; Oh, HK; Oh, HR; Oh, KH; Ohgi, K; Okunade, KS; Oliveira, AG; Olorunfemi, G; Olsen, ML; Olson, BA; Omari, KW; Ondruschka, B; Orfali, R; Orkopoulos, A; Orlowski, RZ; Oser, SM; Oser, TK; Özcan, M; Padilla, V; Paeng, JC; Pajuelo-Lozano, N; Pal, SK; Palmieri, S; Palomeque, E; Pan, W; Panagiotakos, DB; Pandey, M; Pang, D; Pang, Q; Pangarah, CA; Panny, A; Paparella, A; Papirio, S; Papouskova, K; Parang, K; Park, HJ; Park, IK; Park, S; Parker, TL; Parkhomenko, A; Parmon, VN; Parsons, B; Parsons, J; Patel, PR; Patil, S; Patsourakos, NG; Patterson, KC; Pavlidis, P; Pedernera, M; Pedersen, R; Pedraza-Chaverri, J; Pellegrini, M; Peña-Chora, G; Pereira, EDM; Pereira, MADS; Peretz, A; Perez-Padilla, R; Perlman, GY; Perona, R; Petras, C; Phuntsho, S; Picada, JN; Pinder, TA; Piper, LFJ; Pirozzi, F; Pirro, M; Pleckaityte, M; Ploutz-Snyder, LL; Ploutz-Snyder, R; Pogorzelski, A; Poles, L; Postma, AA; Prager, A; Prakash, J; Punn, R; Pützer, BM; Qi, J; Qi, MC; Qi, Y; Qian, J; Qian, Y; Qiang, L; Qiu, J; Qu, Y; Rabiu, KA; Rahighi, S; Rahman, MM; Rahmani, B; Rajkumar, SV; Ramanathan, R; Raras, TYM; Rashi, Y; Rasool, G; Rathore, MG; Ratnawati, R; Ratola, N; Raucci, U; Ray, SK; Razavi, P; Razazi, K; Razek, S; Razi, SS; Reback, M; Reddy, K; Rees, DC; Reginatto, FH; Reich, H; Reis-Filho, JS; Ren, X; Ren, Y; Renner, G; Rey, G; Reymen, B; Riaz, M; Ricci, A; Richardson, PG; Richter, C; Riga, M; Ritchie, C; Rivoal, S; Roberts, W; Robson, ME; Rocha, GZ; Rodrigues, AD; Rogach, AL; Rojas, A; Rosenberg, A; Rosenberg, E; Rosenheck, RA; Roslan, K; Rothenberger, C; Rouschop, KMA; Rubagumya, F; Ryan, CM; Ryder, JW; Saad, MJA; Sacan, O; Sacchi, A; Sahebkar, A; Saini, A; Sainz, B; Sajo, EA; Sakizadeh, J; Saleh, AA; Salgado Júnior, IB; Salvi, R; Samoylova, YV; Samuni, A; Sanchez, DM; Sanchez-Perez, I; Santos, M; Sarapulova, A; Sardot, T; Saud, N; Sauerbier, P; Scaltriti, M; Schaeffer, B; Schalk, DL; Scherschel, K; Schijven, MP; Schreuder, HWR; Schuhmacher, M; Schultz-Lebahn, A; Schwarzl, J; Scott, JM; Sebayang, SK; Seeger, ZL; Segabinazi Peserico, C; Selenica, P; Serio, A; Seruga, B; Shah, A; Shah, C; Shah, PD; Shahrokh Tehraninezhad, E; Shan, A; Shao, Z; Sharma, AMR; Sharma, RK; Shen, J; Shen, R; Shi, X; Shi, Y; Shi, ZE; Shih, YC; Shimohata, H; Shimpi, N; Shin, SH; Shon, HK; Shuvy, M; Siddique, AB; Siegbahn, A; Sikandar, M; Silvani, Y; Singh, A; Singh, AK; Singh, D; Singh, JS; Singh, KP; Singh, M; Situ, B; Skipper, MT; Skouloudi, M; Sloane, BF; Smyrnioudis, N; Snyder, MA; Söhnchen, C; Solis Condor, R; Solit, DB; Someya, S; Song, H; Song, J; Song, W; Song, Y; Sorokina, KN; Soshi, S; Soyer, P; Spitschak, A; Sreekrishnan, TR; Srinivasan, M; Staruschenko, A; Steel, A; Stefan-van Staden, RI; Stein, AM; Strayer, H; Struthers, AD; Su, H; Su, Q; Su, X; Sudore, RL; Sugimura, H; Sugiyama, Y; Sujuti, H; Sumner, SJ; Sun, B; Sun, D; Sun, H; Sun, J; Sun, JY; Sun, X; Sun, Y; Sun, Z; Sung, YC; Surenaud, M; Sutimantanapi, D; Suwandaratne, NS; Swaroop, S; Sychrova, H; Syed, A; Szczepanik, M; Szederjesi, J; Szodorai, R; Tacy, TA; Tadelle, RM; Takayasu, M; Tammeveski, K; Tan, H; Tan, M; Tang, HX; Tang, S; Tang, X; Tanokura, M; Tao, F; Tao, H; Tarafdari, A; Tarín-Carrasco, P; Tasson Tatang, C; Teixeira, JP; Thakur, A; Theobald, A; Thevenot, P; Thomaidis, K; Tian, J; Tillib, SV; Toma, C; Tomita, M; Tonchev, I; Tong, F; Toy, W; Trypuć, M; Tselepis, AD; Tsetseris, L; Tsikouri, GE; Tsikouris, EI; Tsoplifack, CB; Tsoumani, ME; Tsujimoto, R; Tsybin, YO; Tu, J; Tu, TM; Turco, M; Turkyilmaz, IB; Uddin, MJ; Ung, J; Unsihuay, D; Utsunomiya, T; Vagenende, B; Vaishnav, J; Valdes, C; Validad, MH; Valle, J; van Ginkel, MPH; van Grevenstein, WMU; Vanderpuye, V; Vasan, N; Vasilenko, EA; Vasques, GJ; Vavoulis, P; Verani, A; Veziroglu, E; Viegas, A; Vitali, MG; Vitsas, G; Voccio, JP; Vogiatzidis, C; Volow, A; Volpin, F; Vourvahis, M; Wagner, LI; Walkowiak, J; Wallace, R; Wallentin, L; Wan, D; Wan, L; Wan, T; Wang, C; Wang, F; Wang, FN; Wang, H; Wang, J; Wang, L; Wang, Q; Wang, S; Wang, T; Wang, W; Wang, X; Wang, XW; Wang, Y; Wang, YS; Wang, Z; Ward, J; Ward, L; Waseem, R; Watson, DF; Weber, P; Wehrmeister, FC; Wei, CH; Wei, H; Wei, L; Wei, Q; Wei, Y; Weinstock, RS; Weiss, M; Welborn, M; Wen, L; Wen, LM; Wen, Q; Wen, Z; Wesseling, P; Westerbergh, J; White, K; Wick, MP; Willems, S; Wiyasa, IWA; Wójciak, R; Wolkenhauer, O; Won, HH; Wong, J; Woo, YC; Wood, LS; Wu, CT; Wu, CY; Wu, D; Wu, G; Wu, J; Wu, K; Wu, M; Wu, Q; Wu, T; Wu, W; Wu, X; Wu, XT; Wu, Y; Xi, D; Xi, J; Xiang, W; Xiang, Y; Xiao, M; Xiao, Z; Xie, H; Xie, Q; Xie, S; Xie, X; Xing, M; Xing, YL; Xu, C; Xu, X; Xu, Y; Xu, Z; Xue, F; Xue, XD; Yaglioglu, HG; Yamada, H; Yamashita, M; Yan, W; Yan, Z; Yanardag, R; Yang, D; Yang, H; Yang, K; Yang, QQ; Yang, R; Yang, S; Yang, T; Yang, X; Yang, Y; Yao, H; Yao, Y; Yari, D; Yassin, MT; Ye, C; Ye, J; Ye, Q; Yildiz, EA; Ying, S; Yoon, H; Yu, D; Yu, K; Yu, N; Yu, PL; Yuan, C; Yuan, D; Yuan, LJ; Yuan, Z; Yuen, N; Zagatto, AM; Zakaria, Y; Zalewski, AM; Zamora, S; Zavorotinskaya, T; Zeid, JL; Zeinoun, T; Zeng, C; Zerby, HN; Zhan, X; Zhang, A; Zhang, D; Zhang, E; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, M; Zhang, P; Zhang, Q; Zhang, QY; Zhang, RG; Zhang, S; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, CK; Zhao, H; Zhao, J; Zhao, K; Zhao, Q; Zhao, S; Zhao, T; Zhao, XQ; Zhao, Y; Zhao, Z; Zheng, J; Zheng, L; Zheng, Y; Zhou, B; Zhou, G; Zhou, L; Zhou, T; Zhou, X; Zhu, C; Zhu, J; Zhu, Y; Zhu, ZQ; Zhuang, T; Zimmermannova, O; Zin, NNINM; Zisimos, K; Zoghebi, KA; Zonder, JA; Zou, C; Zwirner, J | 1 |
| Chen, J; Chen, L; Hu, HH; Huang, X; Li, TY; Lin, SC; Lin, SY; Lin, ZZ; Liu, DT; Liu, Z; Shi, Y; Song, E; Song, L; Xie, C; Yang, Y; Ye, J; Zhao, H; Zhou, J | 1 |
| Asan, A; Attaran, S; Feinberg, A; Hopkins, BL; Neumann, CA; Skoko, JJ; Woo, HA; Wood, LE; Wright, MK | 1 |
| Clark, JL; Janusis, J; Mercado-Matos, J; Piper, AJ; Shaw, LM | 1 |
| Barnes, PJ; Chedrawe, ER; Thomas, LN; Too, CKL | 1 |
| Choi, EK; Choi, KC; Hong, CW; Kim, JG; Kim, YS; Park, HS; Park, JB | 1 |
| Cao, X; Cong, YS; Dai, X; Feng, XH; Guo, X; Ji, X; Li, L; Liang, T; Si, Y; Tang, M; Xia, Z; Xu, L; Yan, H; Ye, S; Zhang, H; Zhao, B; Zhao, H; Zhou, Q; Zhu, C | 1 |
| Aggouraki, D; Georgoulias, V; Kallergi, G; Martin, SS; Stournaras, C; Zacharopoulou, N | 1 |
| Abe, F; Chen, C; Fikry, MA; Ichikawa, Y; Kato, M; Okita, Y; Shibuya, A; Suzuki, H; Watanabe, Y | 1 |
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| Abraham, I; McCroskey, MC; Sampson, KE | 1 |
| DiGiovanna, MP; Stern, DF | 1 |
| Hara, S; Kita, Y; Koski, R; Mayer, J; Nicolson, M; Ratzkin, B; Rohde, M; Watson, E; Zamborelli, T | 1 |
| Aruffo, A; Carlton, GW; Culouscou, JM | 1 |
| Baruch, A; Elroy-Stein, O; Keydar, I; Wreschner, DH; Zrihan-Licht, S | 1 |
| Barff, J; Brankow, D; Gullick, WJ; Hu, S; Kita, YA; Liu, N; Luo, Y; Nicolson, M; Prigent, SA; Wen, D | 1 |
| Eppenberger, U; Kueng, W; Liu, R; Loop, P; Mueller, H; Wosikowski, K | 1 |
| Arnold, SF; Notides, AC; Vorojeikina, DP | 1 |
| Dilts, CA; Dziubinski, ML; Ethier, SP; Pierce, LJ; Ram, TG | 1 |
| Cho, C; Eberhard, I; Liu, F; Lupu, R; Ma, Z; Rosen, N; Sepp-Lorenzino, L; Serve, H | 1 |
| Beerli, RR; Hynes, NE | 1 |
| Auricchio, F; Bilancio, A; Castoria, G; Di Domenico, M; Migliaccio, A; Rotondi, A | 1 |
| Ethier, SP; Ram, TG | 1 |
| Flynn, DC; Strobl, JS; Wonderlin, WF | 1 |
| Birtwisle-Peyrottes, I; Caldani, C; Ettore, F; Far, DF; Rostagno, P | 1 |
| Das, R; Vonderhaar, BK | 1 |
| Adriaansen-Slot, SS; Rijksen, G; Staal, GE | 1 |
| Akhtar, N; Linstead, D; Wakelam, MJ | 1 |
| Ardini, E; Bufalino, R; Campiglio, M; Colnaghi, MI; Groner, B; Jeschke, M; Ménard, S; Pellegrini, R; Tagliabue, E | 1 |
| Ekena, K; Katzenellenbogen, BS; Lazennec, G; Thomas, JA; Weis, KE | 1 |
| Campbell, DH; Daly, RJ; deFazio, A; Sutherland, RL | 1 |
| Bianco, C; Brandt, R; Ciardiello, F; De Santis, M; Gullick, WJ; Hynes, N; Kannan, S; Kenney, N; Lohmeyer, M; Martinez-Lacaci, I; Normanno, N; Persico, G; Riese, DJ; Salomon, DS; Seno, M; Smith, GH; Stern, DF | 1 |
| Hoekstra, HJ; Kole, AC; Nieweg, OE; Paans, AM; Plukker, JT; Pruim, J; Schraffordt Koops, H; Vaalburg, W | 1 |
| Davis, JG; Greene, MI; Kajino, K; Kajino, Y; O'Rourke, DM; Wang, Q; Weber, BL; Zhang, HB; Zhang, HT; Zhang, X; Zhao, HZ | 1 |
| Deutscher, SL; Glinsky, GV; Glinsky, VV; Peletskaya, EN; Quinn, TP | 1 |
| Komurasaki, T; Morimoto, S; Toyoda, H; Uchida, D | 1 |
| Avraham, H; Deng, B; Keydar, I; McShan, G; Yarden, Y; Zrihan-Licht, S | 1 |
| Ciborowski, P; Finn, OJ; Hsia, S; Magarian-Blander, J; Watkins, SC | 1 |
| Bacus, SS; Klapper, LN; Lenferink, AE; Lyass, L; Pinkas-Kramarski, R; Sela, M; Tzahar, E; van de Poll, ML; van Zoelen, EJ; Yarden, Y | 1 |
| Fang, H; Grimley, PM; Rui, H; Schaber, JD; Xu, J | 1 |
| Hiwada, K; Kohno, N; Kondo, K; Yokoyama, A | 1 |
| Hunzicker-Dunn, M; Kawakatsu, H; Krett, NL; Maizels, ET; Murad, FM; Peters, CA; Rosen, ST; Shanmugam, M | 1 |
| Alves, F; Gish, GD; Pawson, T; Vogel, W | 1 |
| Frasca, F; Giorgino, F; Gliozzo, B; Goldfine, ID; Milazzo, G; Papa, V; Pezzino, V; Scalia, P; Sciacca, L; Sung, CK; Vigneri, R | 1 |
| Frackelton, AR; Stevenson, LE | 1 |
| Safe, S; Smith, R; Wang, W | 1 |
| Kilpatrick, KE; Kinch, MS; Zhong, C | 1 |
| Boeuf, H; Chenard, MP; Moog-Lutz, C; Régnier, CH; Rio, MC; Schreiber, V; Tomasetto, C; Vonesch, JL | 1 |
| Cai, J; Jiang, WG; Mansel, RE | 1 |
| Andò, S; Lanzino, M; Mauro, L; Panno, ML; Salerno, M; Sisci, D; Surmacz, E | 1 |
| Bartholomew, PJ; DePasquale, JA; Vinci, JM | 1 |
| Amin, S; Chandraratna, RA; De Luca, LM; Haque, M; Jones, CS; Matsukuma, K; Vuligonda, V; Zhu, WY | 1 |
| Frackelton, AR; Ravichandran, KS; Stevenson, LE | 1 |
| Nohara, K; Olivera, A; Spiegel, S; Thompson, EW; Wang, F | 1 |
| Altstock, RT; Firon, M; Mittelman, L; Resau, JH; Ronen, D; Sobe, T; Tsarfaty, I; Vande Woude, GF | 1 |
| Albanell, J; Arribas, J; Baselga, J; Codony-Servat, J; Lopez-Talavera, JC | 1 |
| Grijalva, R; Tan, M; Yu, D | 1 |
| Bowers, G; Dent, P; Logsdon, C; Park, JS; Reardon, DB; Schmidt-Ullrich, R; Valerie, K | 1 |
| Honjo, M; Ikeda, M; Naito, N; Tsunekawa, B; Uchida, H; Wada, M | 1 |
| Azimi, M; Brackenbury, R; Fedor-Chaiken, M; Kinch, MS; Wang, B; Zantek, ND | 1 |
| Chazotte-Aubert, L; Hainaut, P; Ohshima, H | 1 |
| Avraham, H; Avraham, S; Fu, Y; Keydar, I; Schinkmann, K; Settleman, J; Shaw, L; Zrihan-Licht, S | 1 |
| Kaulsay, KK; Lee, KO; Lobie, PE; Mertani, HC | 1 |
| Egeblad, M; Jäättelä, M | 1 |
| Liu, J; Ma, Y; Spence, MJ; Streiff, R; Vestal, RE | 1 |
| McGuckin, MA; Quin, RJ | 1 |
| Fujita, T; Fukayama, M; Kadowaki, T; Kimura, S; Matsuda, S; Miki, H; Nagai, R; Sugiyama, T; Taketani, Y; Tobe, K; Tsushima, T; Ueki, K; Waki, H; Yamamoto, T; Yamauchi, N; Yamauchi, T; Yazaki, Y | 1 |
| Eichstetter, I; Iozzo, RV; Santra, M | 1 |
| Benz, CC; DiGiovanna, MP; Edgerton, S; Kasowitz, KM; Liu, S; Moore, D; Stern, DF; Thor, AD | 1 |
| Carr, BI; Kar, S | 1 |
| Hermanto, U; Wang, LH; Zong, CS | 1 |
| Bennett, W; Kaulsay, KK; Lee, KO; Lobie, PE; Zhu, T | 1 |
| Badache, A; Hynes, NE | 1 |
| Bruyneel, EA; Delannoy, P; Goeman, JL; Hilkens, J; Huet, G; Krzewinski-Recchi, MA; Mareel, MM; Oomen, LC; Philippé, J; Steelant, WF; Van der Eycken, J | 1 |
| Adam, L; Kumar, R; McCrea, P; Vadlamudi, RK | 1 |
| de Vries, EG; Jager, PL; Langen, KJ; Piers, DA; Pruim, J; Vaalburg, W | 1 |
| Dupont, J; Le Roith, D | 1 |
| Brémond, A; Dumontet, C; Job, D; Lafanechère, L; Margolis, RL; Mialhe, A; Panh, MH; Payan, R; Peloux, N; Treilleux, I; Wehland, J | 1 |
| Burke, TR; Gao, Y; Voigt, J; Wu, JX; Yang, D | 1 |
| Andò, S; Bellizzi, D; Mauro, L; Miglietta, A; Panno, ML; Salerno, M; Sisci, D; Surmacz, E | 1 |
| Ge, X; Meadows, GG; Zhang, H | 1 |
| Takahashi, K | 1 |
| Li, L; Shaw, PE | 1 |
| Lee, J; Lin, T; Márquez, DC; Pietras, RJ | 1 |
| Adriance, MC; Gendler, SJ; McConnell, EJ; Pockaj, B; Schroeder, JA; Thompson, MC | 1 |
| Campbell, IT; Harvie, MN; Howell, A; Thatcher, N | 1 |
| Arlinghaus, R; Fang, D; Hung, MC; Jing, T; Lan, KH; Lee, S; Li, P; Liu, J; Nagata, Y; Neal, CL; Tan, M; Yu, D | 1 |
| Banerjee, A | 1 |
| D'Alessio, G; De Lorenzo, C; Palmer, DB; Piccoli, R; Ritter, MA | 1 |
| Avraham, H; Avraham, S; Fu, Y; McShan, GD; Park, SY; Zagozdzon, R; Zrihan-Licht, S | 1 |
| Jallal, B; Schlessinger, J; Ullrich, A | 1 |
| Harwerth, IM; Hynes, NE; Marte, BM; Wels, W | 1 |
| Bano, M; Dickson, RB; Kidwell, WR; Lippman, ME; Worland, P | 1 |
| Christianson, TA; Clinton, GM; Lin, YJ | 1 |
| Kamer, AR; Lee, MT; Liebow, C; Schally, AV | 1 |
| Clinton, GM; Li, SW; Lin, YZ | 1 |
| Andrulis, IL; Blackstein, ME; Pawson, T; Wildenhain, Y | 1 |
| Ginsburg, E; Vonderhaar, BK | 1 |
| Aaronson, SA; Arnstein, P; Artrip, J; Di Fiore, PP; DiMarco, E; Kraus, MH; Lonardo, F; Pierce, JH | 1 |
| Bakker, WH; Krenning, EP; Lamberts, SW; Reubi, JC | 1 |
| Weinberg, RA; Yarden, Y | 1 |
| Rijksen, G; Staal, GE; van Oirschot, BA | 1 |
| Bellot, F; Borrello, I; Comoglio, P; King, CR; Schlessinger, J | 1 |
| Bolster, JM; Elsinga, PH; Mulder, NH; Paans, AM; Piers, DA; Vaalburg, W; van Dijk, TH; Woldring, MG; Wynberg, H; Zijlstra, JB | 1 |
| Bhide, SV; Sheth, NA | 1 |
| Holland, JJ; Penhoet, EE | 1 |
| Hersh, EM; Ohno, R | 1 |
9 review(s) available for tyrosine and Breast Neoplasms
| Article | Year |
|---|---|
Antidiabetics, Anthelmintics, Statins, and Beta-Blockers as Co-Adjuvant Drugs in Cancer Therapy.
Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Anthelmintics; Anti-Bacterial Agents; Antihypertensive Agents; Antimalarials; Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Cholesterol; Diabetes Mellitus, Type 2; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Mebendazole; Metformin; Mevalonic Acid; Propranolol; Protein Kinases; Proto-Oncogene Proteins B-raf; Receptors, Adrenergic, beta-2; Tyrosine | 2022 |
The role of HER2 alterations in clinicopathological and molecular characteristics of breast cancer and HER2-targeted therapies: a comprehensive review.
Topics: Breast Neoplasms; Female; Hormones; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Tyrosine | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.
Topics: Adaptor Proteins, Signal Transducing; Breast; Breast Neoplasms; Cell Movement; Disease Progression; DNA-Binding Proteins; Female; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinase 7; Neoplasm Proteins; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; RNA-Binding Proteins; Signal Transduction; Tyrosine | 2012 |
Roles and regulation of stat family transcription factors in human breast cancer.
Topics: Amino Acid Motifs; Animals; Breast Neoplasms; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Mammary Glands, Human; Mice; Milk Proteins; Models, Biological; Phosphorylation; Prognosis; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Structure-Activity Relationship; Trans-Activators; Tyrosine | 2004 |
Protein tyrosine phosphorylation and estradiol action.
Topics: Animals; Breast Neoplasms; Estradiol; Humans; Neoplasm Proteins; Phosphorylation; Receptors, Estradiol; Stimulation, Chemical; Tumor Cells, Cultured; Tyrosine | 1996 |
Mitogenic signal transduction in human breast cancer cells.
Topics: Breast Neoplasms; Calcium; Calmodulin; Cell Division; Cyclic AMP; Female; Humans; Phosphorylation; Potassium Channels; Signal Transduction; Tyrosine | 1995 |
Radiolabeled amino acids: basic aspects and clinical applications in oncology.
Topics: Amino Acids; Brain Neoplasms; Breast Neoplasms; Carbon Radioisotopes; Head and Neck Neoplasms; Humans; Iodine Radioisotopes; Lung Neoplasms; Lymphoma; Methionine; Methyltyrosines; Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Tyrosine | 2001 |
Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects.
Topics: Breast Neoplasms; Cell Division; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Estradiol; Female; Humans; Insulin-Like Growth Factor I; Microfilament Proteins; Mitogen-Activated Protein Kinases; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptor, IGF Type 1; Retinoblastoma Protein; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2001 |
1 trial(s) available for tyrosine and Breast Neoplasms
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
321 other study(ies) available for tyrosine and Breast Neoplasms
| Article | Year |
|---|---|
TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Prognosis; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Threonine; Tyrosine | 2022 |
Induction of CTH expression in response to amino acid starvation confers resistance to anti-LAT1 therapy in MDA-MB-231 cells.
Topics: Amino Acids; Antineoplastic Agents; Benzoxazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cystathionine gamma-Lyase; Female; Gene Knockdown Techniques; Humans; Large Neutral Amino Acid-Transporter 1; RNA, Small Interfering; Tyrosine | 2022 |
Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cytoskeletal Proteins; Female; Humans; Membrane Proteins; Mice; Muscle Proteins; Neoplasm Proteins; Phosphorylation; Receptors, Androgen; Signal Transduction; Tyrosine | 2022 |
Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; Interleukin-8; Proteome; Transcription Factors; Tyrosine | 2022 |
Caveolae Microdomains Mediate STAT5 Signaling Induced by Insulin in MCF-7 Breast Cancer Cells.
Topics: Animals; Breast Neoplasms; Caveolae; Caveolin 1; DNA; Female; Humans; Insulin; Mammals; MCF-7 Cells; Phosphorylation; STAT5 Transcription Factor; Tyrosine | 2023 |
Computational portraits of the tumoral microenvironment in human breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tumor Microenvironment; Tyrosine | 2022 |
A recombinant affitoxin derived from a HER3 affibody and diphteria-toxin has potent and selective antitumor activity.
Topics: Breast Neoplasms; Cell Line, Tumor; Diphtheria Toxin; Female; Humans; Receptor, ErbB-3; Recombinant Fusion Proteins; Tyrosine | 2022 |
The prognostic and predictive values of differential expression of exosomal receptor tyrosine kinases and associated with the PI3K/AKT/mTOR signaling in breast cancer patients undergoing neoadjuvant chemotherapy.
Topics: Breast Neoplasms; Female; Humans; Neoadjuvant Therapy; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; TOR Serine-Threonine Kinases; Tumor Microenvironment; Tyrosine | 2023 |
Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex.
Topics: Anaplastic Lymphoma Kinase; Animals; Antineoplastic Agents; Biomarkers; Breast Neoplasms; Cyclin-Dependent Kinase 9; Female; Humans; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Positive Transcriptional Elongation Factor B; Tyrosine; Ubiquitin-Protein Ligases; United States | 2022 |
BRK confers tamoxifen-resistance in breast cancer via regulation of tyrosine phosphorylation of CDK1.
Topics: Breast Neoplasms; CDC2 Protein Kinase; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Tamoxifen; Tyrosine | 2023 |
Dysregulated ceramides metabolism via PTPN11 exposes a metabolic vulnerability to breast cancer metastasis.
Topics: Breast Neoplasms; Ceramides; Female; Humans; Lipid Metabolism; Melanoma, Cutaneous Malignant; Neoplasms, Second Primary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases, Non-Receptor; Protein-Tyrosine Kinases; Tyrosine | 2023 |
Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
Topics: Breast Neoplasms; Cell Movement; Female; Humans; Paxillin; Phosphorylation; Tyrosine | 2023 |
CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Docetaxel; Drug Carriers; Drug Delivery Systems; Female; Humans; Hyaluronan Receptors; Hyaluronic Acid; Lung Neoplasms; Mice; Molecular Targeted Therapy; Nanomedicine; Nanoparticles; Thioctic Acid; Tissue Distribution; Tyrosine; Xenograft Model Antitumor Assays | 2020 |
BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential.
Topics: Breast Neoplasms; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases; Smad4 Protein; Snail Family Transcription Factors; Transforming Growth Factor beta; Tyrosine; Ubiquitination | 2019 |
CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.
Topics: Biomarkers; Breast Neoplasms; Carcinogenesis; Cell Cycle Proteins; Cell Line, Tumor; Cytokines; Female; Gene Expression Regulation; Genes, Reporter; Humans; Promoter Regions, Genetic; Protein Binding; Protein Transport; RNA Interference; STAT3 Transcription Factor; Tumor Suppressor Proteins; Tyrosine | 2020 |
Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7.
Topics: Breast Neoplasms; Cell Proliferation; Chlorambucil; Endocytosis; Female; Humans; Large Neutral Amino Acid-Transporter 1; MCF-7 Cells; Protein Binding; Time Factors; Tyrosine | 2020 |
Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines.
Topics: Biomarkers, Tumor; Breast; Breast Neoplasms; Canada; Cell Line, Tumor; Cell Proliferation; Cohort Studies; Drug Resistance, Neoplasm; Female; Humans; Phosphorylation; Protein Kinase Inhibitors; Receptor, ErbB-2; Tissue Array Analysis; Trastuzumab; Tyrosine | 2020 |
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; CSK Tyrosine-Protein Kinase; Female; Humans; Lipogenesis; Male; Mammary Neoplasms, Animal; Mice, Mutant Strains; Mice, Transgenic; Phosphatidate Phosphatase; Phosphorylation; Proto-Oncogene Mas; Tyrosine; Xenograft Model Antitumor Assays | 2020 |
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Collagen; Extracellular Matrix; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Mice; Peroxiredoxins; Phosphorylation; Prognosis; Protein-Lysine 6-Oxidase; Survival Analysis; Tyrosine | 2021 |
Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cytoskeleton; Female; Humans; Insulin Receptor Substrate Proteins; Microscopy, Fluorescence; Microtubules; Paclitaxel; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Tubulin; Tyrosine | 2017 |
Prolactin/androgen-inducible carboxypeptidase-D increases with nitrotyrosine and Ki67 for breast cancer progression in vivo, and upregulates progression markers VEGF-C and Runx2 in vitro.
Topics: Androgens; Breast Neoplasms; Carboxypeptidases; Core Binding Factor Alpha 1 Subunit; Cullin Proteins; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; MCF-7 Cells; Nitric Oxide; Prolactin; Receptors, Androgen; Receptors, Prolactin; Tyrosine; Vascular Endothelial Growth Factor C | 2017 |
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-κB.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; HT29 Cells; Humans; Hydrogen Peroxide; Liver Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; NF-kappa B; Phosphorylation; Protein Processing, Post-Translational; RAW 264.7 Cells; rhoA GTP-Binding Protein; Signal Transduction; Tyrosine | 2017 |
Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Adhesion; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Cells, Cultured; Female; HEK293 Cells; Hippo Signaling Pathway; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Staging; Phosphoproteins; Phosphorylation; Prognosis; Protein Serine-Threonine Kinases; Signal Transduction; src-Family Kinases; Transcription Factors; Tyrosine; Xenograft Model Antitumor Assays; YAP-Signaling Proteins | 2017 |
Evaluation of α-tubulin, detyrosinated α-tubulin, and vimentin in CTCs: identification of the interaction between CTCs and blood cells through cytoskeletal elements.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Cell Movement; Cytoskeleton; Epithelial-Mesenchymal Transition; Female; Humans; MCF-7 Cells; Microscopy, Confocal; Middle Aged; Neoplastic Cells, Circulating; Tubulin; Tyrosine; Vimentin | 2018 |
Glycoprotein nmb Is Exposed on the Surface of Dormant Breast Cancer Cells and Induces Stem Cell-like Properties.
Topics: Animals; Breast Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Separation; Epithelial-Mesenchymal Transition; Female; Flow Cytometry; Gene Expression Profiling; Humans; Membrane Glycoproteins; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; RNA Interference; Spheroids, Cellular; Transcription Factors; Tyrosine | 2018 |
Tyrosine phosphorylation of HDAC3 by Src kinase mediates proliferation of HER2-positive breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; CSK Tyrosine-Protein Kinase; Female; Histone Deacetylases; Humans; Phosphorylation; Receptor, ErbB-2; Tyrosine | 2019 |
Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Flavonoids; Flavonols; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Tyrosine | 2019 |
HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth.
Topics: Breast Neoplasms; Creatine; Creatine Kinase, Mitochondrial Form; Humans; Phosphorylation; Receptor, ErbB-2; Tyrosine | 2018 |
Tyrosine Phosphorylation of p27Kip1 Correlates with Palbociclib Responsiveness in Breast Cancer Tumor Cells Grown in Explant Culture.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p27; Female; Humans; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pyridines; Tissue Culture Techniques; Tyrosine | 2019 |
Effect of caveolin-1 on Stat3-ptyr705 levels in breast and lung carcinoma cells.
Topics: Animals; Breast Neoplasms; Caveolin 1; Cells, Cultured; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; STAT3 Transcription Factor; Tyrosine | 2019 |
Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Coumarins; Drug Discovery; Fluorescence; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Molecular Docking Simulation; Phosphorylation; Reactive Oxygen Species; Serine; STAT3 Transcription Factor; Thiophenes; Tyrosine | 2019 |
Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Methotrexate; Middle Aged; Multivariate Analysis; Phosphorylation; Proportional Hazards Models; Protein Processing, Post-Translational; STAT3 Transcription Factor; Treatment Outcome; Tyrosine | 2013 |
Platelet-derived growth factor negatively regulates the insulin-like growth factor signaling pathway through the coordinated action of phosphatidylinositol 3-kinase and protein kinase C beta I.
Topics: Blotting, Western; Breast Neoplasms; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Immunoprecipitation; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C beta; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2013 |
PTPα-mediated Src activation by EGF in human breast cancer cells.
Topics: Acetophenones; Benzopyrans; Biocatalysis; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Immunoblotting; Mutation; Phosphorylation; Protein Binding; Protein Kinase C-delta; Proto-Oncogene Proteins pp60(c-src); Receptor-Like Protein Tyrosine Phosphatases, Class 4; RNA Interference; Serine; Signal Transduction; Tyrosine | 2013 |
Optical spectral fingerprints of tissues from patients with different breast cancer histologies using a novel fluorescence spectroscopic device.
Topics: Adult; Aged; Area Under Curve; Breast; Breast Neoplasms; Carcinoma; Collagen; Discriminant Analysis; Elastin; Female; Humans; Middle Aged; Optical Imaging; ROC Curve; Spectrometry, Fluorescence; Tryptophan; Tyrosine | 2013 |
Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.
Topics: Animals; Breast Neoplasms; Cell Cycle Proteins; Cell Proliferation; DNA Replication; DNA-Binding Proteins; ErbB Receptors; Female; Humans; Mice; Minichromosome Maintenance Complex Component 7; Nuclear Proteins; Phosphorylation; Prognosis; Signal Transduction; src-Family Kinases; Tyrosine | 2013 |
Development of a 5-plex SILAC method tuned for the quantitation of tyrosine phosphorylation dynamics.
Topics: Breast Neoplasms; Cell Line, Tumor; Chromatography, Liquid; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Isotope Labeling; Neoplasm Proteins; Phosphopeptides; Phosphorylation; Protein Kinase Inhibitors; Proteomics; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tandem Mass Spectrometry; Tyrosine | 2013 |
A light-activated NO donor attenuates anchorage independent growth of cancer cells: Important role of a cross talk between NO and other reactive oxygen species.
Topics: Breast Neoplasms; Catalase; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Humans; Hydrogen Peroxide; Light; Nitric Oxide; Organometallic Compounds; Phosphorylation; Proto-Oncogene Proteins c-akt; Superoxide Dismutase; Superoxides; Tyrosine | 2013 |
Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.
Topics: Acetylcysteine; Adherens Junctions; Antigens, CD; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Breast Neoplasms; Cadherins; Cell Movement; Endothelial Cells; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Male; Ovarian Neoplasms; Plant Extracts; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 2013 |
Protein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537.
Topics: Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Humans; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 3; Tamoxifen; Tyrosine | 2014 |
Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phosphatidylethanolamine Binding Protein; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; src-Family Kinases; Tissue Array Analysis; Tyrosine | 2014 |
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; CSK Tyrosine-Protein Kinase; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Estrogen; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Thiazoles; Tyrosine | 2014 |
High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Phosphorylation; Prognosis; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Tyrosine | 2014 |
HER2 mutation status in Japanese HER2-negative breast cancer patients.
Topics: Adult; Antineoplastic Agents; Asian People; Aspartic Acid; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Isoleucine; Japan; Methionine; Middle Aged; Molecular Targeted Therapy; Mutation; Neoplasm Grading; Polymerase Chain Reaction; Receptor, ErbB-2; Sequence Analysis, DNA; Tyrosine | 2014 |
Cks1 proteasomal turnover is a predominant mode of regulation in breast cancer cells: role of key tyrosines and lysines.
Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cells, Cultured; Female; HEK293 Cells; HeLa Cells; Humans; Lysine; MCF-7 Cells; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Proteolysis; Tyrosine | 2015 |
Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
Topics: Acetylation; Animals; Antibiotics, Antineoplastic; Autophagy; Breast Neoplasms; Cell Division; Cell Line, Tumor; Disulfides; Doxorubicin; Drug Resistance, Neoplasm; Female; G2 Phase; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Membrane Proteins; Mice; Mice, Nude; Neoplasm Transplantation; Sirtuin 1; Tumor Suppressor Protein p53; Tyrosine; Xenograft Model Antitumor Assays | 2015 |
Phosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnover.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Female; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Immunoprecipitation; p21-Activated Kinases; Paxillin; Phosphorylation; Protein Binding; Rho Guanine Nucleotide Exchange Factors; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2015 |
CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases.
Topics: Antigens, CD; Antigens, Neoplasm; Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; Female; HEK293 Cells; Humans; Neoplasm Proteins; Phosphorylation; Protein Kinase C; src-Family Kinases; Tyrosine | 2015 |
Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators.
Topics: Aspartic Acid; Breast Neoplasms; Female; Heterografts; Humans; Mutation; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tyrosine | 2015 |
Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer.
Topics: Blotting, Western; Breast Neoplasms; Carcinoma, Renal Cell; Catenins; Cell Transformation, Neoplastic; Delta Catenin; Female; Humans; Immunoenzyme Techniques; Immunoprecipitation; Kidney Neoplasms; Phosphoproteins; Phosphorylation; Protein Binding; Serine; Threonine; Tissue Array Analysis; Tumor Cells, Cultured; Tyrosine | 2015 |
Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER).
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; ErbB Receptors; Female; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 3; Receptors, Estrogen; Tyrosine | 2015 |
Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.
Topics: Breast Neoplasms; Colonic Neoplasms; Female; GRB2 Adaptor Protein; HEK293 Cells; Humans; Male; MAP Kinase Signaling System; Phosphorylation; Prostatic Neoplasms; Protein Multimerization; Signal Transduction; Son of Sevenless Proteins; src Homology Domains; Tissue Array Analysis; Tyrosine | 2015 |
A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; Enzyme Activation; Female; Humans; Immunoenzyme Techniques; Immunoprecipitation; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Tumor Cells, Cultured; Tyrosine; Xenograft Model Antitumor Assays | 2016 |
Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10.
Topics: Breast Neoplasms; Catalysis; Cell Line, Tumor; Cell Nucleus; Collagen; DNA, Complementary; Female; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; HEK293 Cells; Humans; Microscopy, Fluorescence; Plasmids; RNA-Binding Proteins; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Tyrosine | 2016 |
The Association between EGFR and cMET Expression and Phosphorylation and Its Prognostic Implication in Patients with Breast Cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; ErbB Receptors; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Phosphorylation; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins c-met; Receptor, ErbB-2; Triple Negative Breast Neoplasms; Tyrosine | 2016 |
Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Survival; Estrogen Receptor beta; Female; HEK293 Cells; Humans; Ki-67 Antigen; Ligands; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Transplantation; p300-CBP Transcription Factors; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Tyrosine; Ubiquitination | 2016 |
[Phosphorylation of ezrin Tyr477 is critical in invasion of breast cancer cells stimulated by precursor of nerve growth factor].
Topics: Breast Neoplasms; Cell Line, Tumor; Cytoskeletal Proteins; Humans; MCF-7 Cells; Neoplasm Invasiveness; Nerve Growth Factor; Phosphorylation; Signal Transduction; Transfection; Tyrosine | 2016 |
Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.
Topics: Adult; Aged; Breast Neoplasms; Female; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Humans; Microfilament Proteins; Middle Aged; Phosphorylation; Prognosis; Signal Transduction; Tyrosine; Vesicular Transport Proteins; Young Adult | 2016 |
Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling.
Topics: Breast Neoplasms; Cell Line, Tumor; Cluster Analysis; Female; Humans; Mass Spectrometry; Phosphopeptides; Phosphorylation; Proteomics; Receptor, ErbB-2; Staining and Labeling; Tyrosine | 2017 |
Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gene Knockdown Techniques; Humans; Interleukin-6; Mice; Mutation; Neoplasm Metastasis; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Tumor Burden; Tyrosine | 2017 |
A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression.
Topics: Breast Neoplasms; Cell Line, Tumor; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Humans; Immunohistochemistry; Integrin alpha6beta4; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Signal Transduction; src-Family Kinases; Tyrosine | 2008 |
Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis.
Topics: Adult; Aged; Aged, 80 and over; Alkenes; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Invasiveness; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prognosis; Receptors, CXCR4; Tyrosine | 2008 |
Mislocalization of cell-cell adhesion complexes in tamoxifen-resistant breast cancer cells with elevated c-Src tyrosine kinase activity.
Topics: beta Catenin; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; CSK Tyrosine-Protein Kinase; Drug Resistance, Neoplasm; Estrogen Antagonists; Estrogen Receptor Modulators; Humans; Phosphorylation; Protein-Tyrosine Kinases; src-Family Kinases; Tamoxifen; Tyrosine | 2009 |
Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity.
Topics: Adenocarcinoma; Amino Acid Motifs; Amino Acid Substitution; Animals; Binding Sites; Breast Neoplasms; Catalysis; Cell Line; Cell Line, Tumor; Epithelial Cells; Female; HSP90 Heat-Shock Proteins; Humans; Male; Mice; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Prostatic Neoplasms; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Structure-Activity Relationship; Tyrosine | 2009 |
Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors.
Topics: Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; ErbB Receptors; Female; Humans; Immunoenzyme Techniques; In Situ Hybridization, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Staging; Phosphorylation; Prognosis; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Survival Rate; Tissue Array Analysis; Tyrosine | 2009 |
Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell-Free System; Cisplatin; Drug Resistance, Neoplasm; Enzyme Activation; ErbB Receptors; Female; Glioma; Glutathione S-Transferase pi; Humans; Lapatinib; Mice; Mice, Nude; Models, Molecular; Molecular Sequence Data; Neoplasm Transplantation; Phosphorylation; Protein Conformation; Quinazolines; Recombinant Proteins; RNA, Small Interfering; Signal Transduction; Static Electricity; Transplantation, Heterologous; Tyrosine | 2009 |
Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.
Topics: Animals; Breast Neoplasms; Cell Communication; Cell Differentiation; Cell Line; Cell Proliferation; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; GRB2 Adaptor Protein; Humans; Janus Kinase 2; Mammary Glands, Human; MAP Kinase Signaling System; Phosphorylation; Prolactin; ras Proteins; STAT5 Transcription Factor; Tumor Suppressor Proteins; Tyrosine | 2009 |
Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast cancer progression.
Topics: Biomarkers, Tumor; Breast Neoplasms; Disease Progression; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neuregulin-1; Phosphorylation; Prognosis; Protein Phosphatase 2; Protein-Tyrosine Kinases; Receptor, ErbB-2; Signal Transduction; Tissue Array Analysis; Tumor Cells, Cultured; Tyrosine | 2009 |
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Neoplasm Invasiveness; Paxillin; Recombinant Fusion Proteins; RNA, Small Interfering; src-Family Kinases; Tyrosine | 2009 |
Increased production and secretion of HGF alpha-chain and an antagonistic HGF fragment in a human breast cancer progression model.
Topics: Blotting, Western; Breast Neoplasms; Cell Transformation, Neoplastic; Culture Media, Conditioned; Disease Progression; Genes, ras; Hepatocyte Growth Factor; Humans; Mesoderm; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-met; Tyrosine | 2009 |
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Humans; Insulin-Like Growth Factor I; Mice; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Phosphorylation; Point Mutation; Protein Binding; Proto-Oncogene Proteins c-abl; Receptors for Activated C Kinase; Receptors, Cell Surface; Tyrosine | 2009 |
Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.
Topics: Binding Sites; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Communication; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cortactin; Cross-Linking Reagents; Cytoplasm; Enzyme Activation; Female; Green Fluorescent Proteins; Humans; Integrins; Intracellular Signaling Peptides and Proteins; Microscopy, Fluorescence; Phosphorylation; Protein Binding; Protein Transport; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Syk Kinase; Transfection; Tyrosine; Vinculin | 2009 |
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.
Topics: Animals; Blotting, Western; Breast Neoplasms; Catalytic Domain; Cell Line; Cell Line, Tumor; Cell Movement; Chemotaxis; Focal Adhesion Kinase 1; HeLa Cells; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase Kinases; Mutation; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Transfection; Tyrosine | 2009 |
Hexachlorobenzene induces cell proliferation and IGF-I signaling pathway in an estrogen receptor alpha-dependent manner in MCF-7 breast cancer cell line.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP1A1; DNA Fragmentation; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gene Expression Regulation; Hexachlorobenzene; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Pesticides; Phosphorylation; Receptor, Insulin; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Tyrosine | 2010 |
BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Crk-Associated Substrate Protein; Female; Fibronectins; Guanine Nucleotide Exchange Factors; Humans; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); RNA, Small Interfering; Signal Transduction; src-Family Kinases; Transfection; Tyrosine | 2010 |
Copine-III interacts with ErbB2 and promotes tumor cell migration.
Topics: Binding Sites; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Models, Biological; Ovarian Neoplasms; Phosphoproteins; Prostatic Neoplasms; Protein Binding; Receptor, ErbB-2; RNA Interference; Tyrosine | 2010 |
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Core Binding Factor Alpha 3 Subunit; Cytoplasm; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Phosphorylation; Protein Transport; RNA, Small Interfering; src-Family Kinases; Stomach Neoplasms; Tyrosine | 2010 |
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.
Topics: Administration, Oral; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Female; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Phosphorylation; Tyrosine; Xenograft Model Antitumor Assays | 2010 |
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Topics: Animals; Breast Neoplasms; Cell Membrane; Disease Progression; Female; Humans; Male; Mice; Mice, Transgenic; Phosphorylation; Prostatic Intraepithelial Neoplasia; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Tyrosine | 2010 |
Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and beta-catenin/Wnt pathways.
Topics: Animals; beta Catenin; Bone Neoplasms; Breast Neoplasms; Female; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Neoplasm Proteins; Phosphorylation; Prognosis; Proto-Oncogene Proteins c-met; Tyrosine; Wnt Proteins; Xenograft Model Antitumor Assays | 2010 |
Variations in systemic biomarkers of oxidative/nitrosative stress and DNA damage before and during the consequent two cycles of chemotherapy in breast cancer patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Biomarkers, Tumor; Breast Neoplasms; Deoxyguanosine; DNA Damage; Female; Humans; Middle Aged; Nitrates; Nitrites; Nitrosation; Oxidation-Reduction; Oxidative Stress; Prognosis; Thiobarbituric Acid Reactive Substances; Tyrosine | 2010 |
The nitrative and oxidative stress in blood platelets isolated from breast cancer patients: the protectory action of aronia melanocarpa extract.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Blood Proteins; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Middle Aged; Oxidative Stress; Photinia; Plant Extracts; Tyrosine | 2010 |
Antisense inhibition of amphiregulin expression reduces EGFR phosphorylation in transformed human breast epithelial cells.
Topics: Amphiregulin; Antisense Elements (Genetics); Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phosphorylation; Tyrosine | 2010 |
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.
Topics: Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Female; Gene Expression Regulation; Genes, Reporter; Humans; Paclitaxel; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Tubulin; Tubulin Modulators; Tyrosine; Vinblastine; Vinorelbine | 2010 |
Differential expression of glu-tubulin in relation to mammary gland disease.
Topics: Adult; Aged; Aged, 80 and over; Breast Diseases; Breast Neoplasms; Female; Glutamic Acid; Humans; Middle Aged; Tubulin; Tyrosine | 2010 |
Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; ErbB Receptors; Female; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kaplan-Meier Estimate; Mammary Neoplasms, Experimental; Mice; Neoplasms, Basal Cell; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proteomics; Proto-Oncogene Proteins c-met; RNA Interference; Signal Transduction; src-Family Kinases; Tyrosine | 2010 |
Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement.
Topics: Biopsy; Breast Neoplasms; Cell Adhesion; Cytoskeleton; Epithelium; Female; Humans; Immunohistochemistry; Mesoderm; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Proteins; Tubulin; Twist-Related Protein 1; Tyrosine | 2010 |
Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Surface Extensions; Cells, Cultured; Fatty Acid-Binding Proteins; Female; Fluorescence Resonance Energy Transfer; Fluorescent Antibody Technique; Gelatin; Humans; Immunoenzyme Techniques; Immunoprecipitation; Mice; Mice, Nude; Microtubule-Associated Proteins; Minor Histocompatibility Antigens; Neoplasm Invasiveness; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; src-Family Kinases; Tyrosine; Wiskott-Aldrich Syndrome Protein, Neuronal | 2010 |
Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation.
Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line; Cell Line, Tumor; Gene Knock-In Techniques; Gene Knockdown Techniques; Humans; Janus Kinase 2; Lactic Acid; Phosphorylation; Prolactin; Pyruvate Kinase; Rats; Receptors, Prolactin; Signal Transduction; Tyrosine | 2010 |
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.
Topics: Actins; Adaptor Proteins, Signal Transducing; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cortactin; Cytoskeleton; Female; Humans; Neoplasm Invasiveness; Oncogene Proteins; Phosphorylation; Protein Binding; Pseudopodia; src Homology Domains; Tyrosine | 2010 |
Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chlorambucil; Female; Humans; Receptor, ErbB-2; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2010 |
Is there an association with phosphorylation and dephosphorylation of Src kinase at tyrosine 530 and breast cancer patient disease-specific survival.
Topics: Adult; Aged; Breast Neoplasms; Disease-Free Survival; Female; Humans; Middle Aged; Phosphorylation; src-Family Kinases; Tyrosine | 2010 |
Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Breast Neoplasms; Cell Proliferation; Female; Humans; Immunoprecipitation; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; RNA, Small Interfering; STAT3 Transcription Factor; Tumor Cells, Cultured; Tyrosine | 2011 |
Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative.
Topics: Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Breast Neoplasms; Caspase 8; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Estrogens; Female; Humans; Insulin; Insulin-Like Growth Factor I; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Oxazepines; Phosphorylation; Receptor, IGF Type 1; Signal Transduction; Sulfonamides; Transplantation, Heterologous; Tyrosine | 2011 |
The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: molecular target on cancer metabolism.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drugs, Chinese Herbal; Female; Genome-Wide Association Study; Glycolysis; Humans; Hydrolyzable Tannins; Microarray Analysis; Molecular Targeted Therapy; Pyruvic Acid; Rhus; Tyrosine | 2011 |
A critical step for JNK activation: isomerization by the prolyl isomerase Pin1.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; Female; Gene Expression Regulation; HEK293 Cells; HeLa Cells; Humans; Jurkat Cells; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8; NIMA-Interacting Peptidylprolyl Isomerase; Oxidative Stress; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Binding; Protein Conformation; Proteolysis; Subtilisin; Threonine; Tyrosine | 2012 |
Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.
Topics: Animals; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; Hydrazones; Immunoprecipitation; Mammary Neoplasms, Animal; Mice; Mice, SCID; Microscopy, Fluorescence, Multiphoton; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Rats; Receptor, ErbB-3; Signal Transduction; Sulfonamides; Transplantation, Heterologous; Tyrosine | 2012 |
Estrogen receptor alpha phosphorylated at tyrosine 537 is associated with poor clinical outcome in breast cancer patients treated with tamoxifen.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Estrogen Receptor alpha; Female; Follow-Up Studies; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Multivariate Analysis; Phosphorylation; Receptor, ErbB-2; Tamoxifen; Tissue Array Analysis; Treatment Outcome; Tyrosine | 2010 |
Trastuzumab and lapatinib modulation of HER2 tyrosine/threonine phosphorylation and cell signaling.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Female; Humans; Lapatinib; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; Threonine; Trastuzumab; Tyrosine | 2012 |
Elevated NRD1 metalloprotease expression plays a role in breast cancer growth and proliferation.
Topics: Apoptosis; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Disease Progression; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunohistochemistry; Metalloproteases; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tyrosine; Up-Regulation | 2011 |
Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells.
Topics: Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Dependovirus; Female; Genetic Vectors; Humans; Liver Neoplasms; Mice; Mutagenesis, Site-Directed; Proteasome Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-met; Transduction, Genetic; Transplantation, Heterologous; Tyrosine; Virus Integration | 2012 |
Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility.
Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Down-Regulation; Doxycycline; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha2; Lipoproteins; Matrix Metalloproteinases; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Plasminogen Activators; Protein Isoforms; RNA Interference; Signal Transduction; Tyrosine | 2011 |
Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after the surgery and various phases of the chemotherapy.
Topics: Adult; Aged; Antioxidants; Biomarkers; Blood Platelets; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fruit; Glutathione; Humans; Middle Aged; Oxidative Stress; Phenols; Photinia; Plant Extracts; Superoxides; Tyrosine | 2012 |
SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines.
Topics: Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chlorambucil; Computer Simulation; Estrogen Receptor alpha; Female; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Models, Molecular; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2012 |
Relationship between thiol, tyrosine nitration and carbonyl formation as biomarkers of oxidative stress and changes of hemostatic function of plasma from breast cancer patients before surgery.
Topics: Adult; Aged; Antioxidants; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Female; Hemostasis; Humans; Middle Aged; Neoplasm Invasiveness; Nitrosation; Oxidative Stress; Protein Carbonylation; Sulfhydryl Compounds; Tyrosine | 2012 |
Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines.
Topics: Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chlorambucil; Drug Design; Estrogen Receptor alpha; Female; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Structure; Ovarian Neoplasms; Tyrosine; Uterine Neoplasms | 2012 |
Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells.
Topics: Active Transport, Cell Nucleus; Animals; Breast Neoplasms; Cell Cycle Checkpoints; Cell Growth Processes; Cell Line; Cell Line, Tumor; Cell Nucleus; Chlorocebus aethiops; COS Cells; Cyclin D1; Cytoplasm; Estradiol; Estrogen Receptor alpha; Exportin 1 Protein; Female; Forkhead Transcription Factors; Humans; Karyopherins; MCF-7 Cells; Mice; Mutation; NIH 3T3 Cells; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; ran GTP-Binding Protein; Receptors, Cytoplasmic and Nuclear; S Phase; src-Family Kinases; Transcription, Genetic; Tyrosine | 2012 |
Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Female; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Phosphorylation; Prognosis; Protein-Tyrosine Kinases; STAT3 Transcription Factor; Survival Analysis; Tissue Array Analysis; Tyrosine | 2012 |
Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer.
Topics: Animals; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Knockout Techniques; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Phosphorylation; Protein Tyrosine Phosphatases, Non-Receptor; Signal Transduction; STAT3 Transcription Factor; Tyrosine; Xenograft Model Antitumor Assays | 2012 |
Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma; Cell Movement; Cytoskeletal Proteins; Female; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2012 |
RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation.
Topics: Aminoquinolines; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; Cyclin B; Cyclin-Dependent Kinases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Female; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Humans; M Phase Cell Cycle Checkpoints; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyrimidines; rac1 GTP-Binding Protein; Signal Transduction; Tumor Suppressor Proteins; Tyrosine | 2012 |
Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells.
Topics: Animals; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Movement; Cells, Cultured; Female; Fibroblasts; Focal Adhesions; GTP Phosphohydrolases; HEK293 Cells; Humans; Mice; Phosphorylation; Rats; rho-Associated Kinases; src-Family Kinases; Tyrosine | 2012 |
The chemoselective reactions of tyrosine-containing G-protein-coupled receptor peptides with [Cp*Rh(H2O)3](OTf)2, including 2D NMR structures and the biological consequences.
Topics: Binding, Competitive; Breast Neoplasms; Female; HT29 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Organometallic Compounds; Peptides; Protein Binding; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Rhodium; Tyrosine | 2012 |
Development of (99m)Tc-EC-tyrosine for early detection of breast cancer tumor response to the anticancer drug melphalan.
Topics: Amino Acid Transport System y+L; Animals; Breast Neoplasms; Chelating Agents; Cysteine; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Ki-67 Antigen; Melphalan; Neoplasm Proteins; Organotechnetium Compounds; Radionuclide Imaging; Rats; Rats, Inbred F344; Tissue Distribution; Treatment Outcome; Tyrosine | 2013 |
Involvement of the Src-cortactin pathway in migration induced by IGF-1 and EGF in human breast cancer cells.
Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Movement; Cortactin; Epidermal Growth Factor; Female; Focal Adhesions; Humans; Insulin-Like Growth Factor I; MCF-7 Cells; Phosphorylation; Protein Transport; Signal Transduction; src-Family Kinases; Tyrosine | 2012 |
Antitumoral and mechanistic studies of ianthelline isolated from the Arctic sponge Stryphnus fortis.
Topics: Animals; Antineoplastic Agents; Biological Products; Breast Neoplasms; Carcinoma; Cell Division; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Humans; Imidazoles; Leukemia; Melanoma; Porifera; Protein Kinase Inhibitors; Sea Urchins; Spindle Apparatus; Tyrosine | 2012 |
Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation.
Topics: Blotting, Western; Breast Neoplasms; Caveolae; Caveolin 1; Cell Membrane; Early Growth Response Protein 1; Female; Fluorescent Antibody Technique; Focal Adhesions; Gene Expression Regulation; Humans; Mechanotransduction, Cellular; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 2012 |
Chemotherapy modulates the biological activity of breast cancer patients plasma: the protective properties of black chokeberry extract.
Topics: Adult; Antioxidants; Biomarkers; Blood Platelets; Breast Neoplasms; Case-Control Studies; Cyclophosphamide; Doxorubicin; Female; Fruit; Hemostasis; Humans; Lipid Peroxidation; Middle Aged; Oxidative Stress; Photinia; Plant Extracts; Poland; Tyrosine | 2013 |
Effects of PPARγ agonists on the expression of leptin and vascular endothelial growth factor in breast cancer cells.
Topics: Benzophenones; Binding Sites; Breast Neoplasms; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Leptin; Ligands; MCF-7 Cells; PPAR gamma; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor; Thiazolidinediones; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model.
Topics: Analgesics; Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Breast Neoplasms; Cell Division; Disease Models, Animal; Disease Progression; ErbB Receptors; Female; Isoflavones; Mice; Mice, Inbred ICR; Mice, Nude; Mitotic Index; Neoplasm Metastasis; Osteoclasts; Phosphorylation; Treatment Outcome; Tyrosine | 2002 |
Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells.
Topics: Animals; Blotting, Western; Breast; Breast Neoplasms; DNA, Complementary; Epithelial Cells; ErbB Receptors; Genes, Tumor Suppressor; Humans; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Proteins; Serpins; Signal Transduction; Subcellular Fractions; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 2002 |
Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.
Topics: Breast Neoplasms; Cell Line, Transformed; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Immunoblotting; Isoenzymes; Oligonucleotides, Antisense; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Receptor, EphA2; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Vanadates | 2002 |
Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor.
Topics: Adenocarcinoma; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; DNA, Neoplasm; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-1; Interleukin-6; Phosphoproteins; Phosphorylation; Receptor, IGF Type 1; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Association between nitrotyrosine levels and microvascular density in human breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Immunohistochemistry; Mass Spectrometry; Nitric Oxide; Tyrosine | 2002 |
Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Survival; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Humans; In Situ Nick-End Labeling; Insulin Receptor Substrate Proteins; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 2002 |
Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cohort Studies; DNA-Binding Proteins; DNA, Neoplasm; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Milk Proteins; Phosphorylation; Prognosis; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2002 |
Bombesin and epidermal growth factor potentiate the effect of cytotoxic LH-RH analog AN-152 in vitro.
Topics: Antineoplastic Agents; Bombesin; Breast Neoplasms; Cell Division; Doxorubicin; Drug Combinations; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Gastrin-Releasing Peptide; Gonadotropin-Releasing Hormone; Humans; In Vitro Techniques; Microscopy, Confocal; Phosphorylation; Receptors, Bombesin; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2002 |
The role of Stat5 in estrogen receptor-positive breast cancer.
Topics: Amino Acid Sequence; Animals; Apoptosis; Breast; Breast Neoplasms; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Mice; Milk Proteins; Molecular Sequence Data; Phosphorylation; Receptors, Estrogen; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2002 |
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Breast Neoplasms; GRB2 Adaptor Protein; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Lymphoma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Receptors, Prolactin; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 2003 |
Structural analysis of the ErbB-2 receptor using monoclonal antibodies: Implications for receptor signalling.
Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Binding, Competitive; Breast Neoplasms; Computer Simulation; DNA Primers; Epitope Mapping; Female; Gene Library; Genes, erbB-1; Glycine; Humans; Immunoblotting; MAP Kinase Signaling System; Models, Molecular; Peptide Fragments; Phosphorylation; Polymerase Chain Reaction; Precipitin Tests; Protein Conformation; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 2003 |
Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice; Neuregulin-1; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2003 |
KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Breast Neoplasms; Chromosome Mapping; Chromosomes, Human, Pair 11; Codon; DNA, Complementary; Exons; Expressed Sequence Tags; Genome, Human; Humans; Intracellular Signaling Peptides and Proteins; Introns; Leucine Zippers; Lung Neoplasms; Mice; Microfilament Proteins; Models, Genetic; Molecular Sequence Data; Myosin Heavy Chains; Myosins; Phosphorylation; Protein Structure, Tertiary; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Tissue Distribution; Tyrosine | 2003 |
Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.
Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Mitogens; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-met; Survival Rate; Tumor Cells, Cultured; Tyrosine | 2003 |
Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Caspase Inhibitors; Cell Survival; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Female; Humans; In Situ Nick-End Labeling; Laminin; Matrix Metalloproteinase 11; Metalloendopeptidases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiophenes; Transfection; Tumor Cells, Cultured; Tyrosine | 2003 |
[SUCI02 inhibits HER-2/neu receptor tyrosine kinase phosphorylation and growth of HER-2/neu-overexpressing breast cancer cells].
Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; Humans; Hydroxy Acids; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Tyrosine | 2003 |
[Distinctive infrared spectral features in human breast cancer].
Topics: Breast Neoplasms; Female; Glycogen; Humans; Spectroscopy, Fourier Transform Infrared; Threonine; Tyrosine | 2000 |
ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 over
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; CDC2 Protein Kinase; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclophosphamide; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Immunohistochemistry; Methotrexate; Middle Aged; Phosphorylation; Receptor, ErbB-2; RNA, Messenger; Tyrosine; Up-Regulation | 2003 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells.
Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; ErbB Receptors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myosin-Light-Chain Kinase; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; rho-Associated Kinases; Transforming Growth Factor alpha; Tyrosine | 2003 |
Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; DNA, Complementary; Enzyme Inhibitors; Genes, Reporter; Humans; Hydrogen Peroxide; Hypoxia; I-kappa B Proteins; Luciferases; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Microscopy, Fluorescence; Models, Biological; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidation-Reduction; Oxygen; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Serine; Signal Transduction; Time Factors; Transfection; Tyrosine; Urokinase-Type Plasminogen Activator; Vanadates | 2003 |
Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells.
Topics: Breast Neoplasms; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Focal Adhesion Kinase 2; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Humans; Mutation; Neuregulin-1; Nuclear Proteins; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-abl; Repressor Proteins; Retinoblastoma-Like Protein p130; Tyrosine | 2004 |
Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers.
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Cell Differentiation; Cell Nucleus; DNA-Binding Proteins; Female; Humans; Microfilament Proteins; Milk Proteins; Muscle Proteins; Phosphorylation; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tumor Suppressor Proteins; Tyrosine | 2004 |
Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Blotting, Western; Breast Neoplasms; Cell Division; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin-Like Growth Factor I; Ligands; MAP Kinase Signaling System; Oligonucleotides; Oligonucleotides, Antisense; Phosphorylation; Precipitin Tests; Prognosis; Protein Binding; Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptor, ErbB-2; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Trastuzumab; Tyrosine | 2004 |
Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Female; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intracellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, CXCR4; Tyrosine | 2004 |
[Relationship between protein tyrosine phosphorylation level and anoikis resistance of breast tumor cell lines].
Topics: Animals; Anoikis; Breast Neoplasms; Cell Line, Tumor; Dogs; Female; Genistein; Humans; Phosphorylation; Tyrosine | 2004 |
Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins.
Topics: Breast Neoplasms; Cell Line, Tumor; Deferoxamine; DNA; DNA Replication; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radicals; Humans; Hydrophobic and Hydrophilic Interactions; Iron Chelating Agents; Peptides, Cyclic; Ribonucleotide Reductases; Tyrosine | 2004 |
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Calcium; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; In Situ Nick-End Labeling; Janus Kinase 1; Luciferases; Mice; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tyrosine; Up-Regulation | 2004 |
Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: implications for adjuvant use of kinase-inhibitory drugs.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Chromatography; Cytoskeleton; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Humans; Immunoblotting; Ligands; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasms; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 2004 |
Antioxidative response for nitric oxide production in breast carcinoma.
Topics: Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Papillary; Catalase; Female; Free Radical Scavengers; Humans; Middle Aged; Neoplasms, Ductal, Lobular, and Medullary; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxidation-Reduction; Oxidative Stress; Protein Isoforms; Superoxide Dismutase; Tyrosine; Vascular Endothelial Growth Factor A | 2004 |
Analysis of estrogen receptor alpha signaling complex at the plasma membrane.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Membrane; Estrogen Receptor alpha; Female; HSP70 Heat-Shock Proteins; Humans; Mass Spectrometry; Phosphorylation; Protein Structure, Tertiary; Signal Transduction; Transcriptional Activation; Tubulin; Tyrosine | 2004 |
17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.
Topics: Animals; Breast Neoplasms; Cell Line; Chlorocebus aethiops; Disease Progression; Estradiol; Humans; Hyperplasia; Male; Mice; Mitochondria; Neoplasm Metastasis; Oxidoreductases; Phosphorylation; Prostatic Neoplasms; Protein Binding; Protein Transport; Receptors, Androgen; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Tyrosine; Up-Regulation; WW Domain-Containing Oxidoreductase | 2005 |
Breast adenocarcinoma cell adhesion to the vascular subendothelium in whole blood and under flow conditions: effects of alphavbeta3 and alphaIIbbeta3 antagonists.
Topics: Abciximab; Acetates; Adenocarcinoma; Antibodies, Monoclonal; Blood Platelets; Blood Vessels; Breast Neoplasms; Cell Adhesion; Endothelium, Vascular; Extracellular Matrix; Female; Humans; Immunoglobulin Fab Fragments; Integrin alphaVbeta3; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Receptors, Vitronectin; Regional Blood Flow; Tumor Cells, Cultured; Tyrosine | 2004 |
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.
Topics: 14-3-3 Proteins; Adenoviridae; Apoptosis; Blotting, Northern; BRCA1 Protein; Breast Neoplasms; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; DNA; DNA Damage; Down-Regulation; Enzyme Activation; G2 Phase; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nuclear Proteins; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tyrosine | 2005 |
Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Cetuximab; Colonic Neoplasms; Dose-Response Relationship, Drug; ErbB Receptors; Glycoproteins; Humans; Ligands; Mice; Neuregulin-1; NIH 3T3 Cells; Phosphorylation; Rats; Receptor, ErbB-2; Recombinant Fusion Proteins; Trastuzumab; Tyrosine | 2005 |
Novel hydroxyl naphthoquinones with potent Cdc25 antagonizing and growth inhibitory properties.
Topics: Antineoplastic Agents; Biotinylation; Blotting, Western; Breast Neoplasms; Carcinoma, Hepatocellular; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell-Free System; DNA; Dual Specificity Phosphatase 1; Flavonoids; Flow Cytometry; Humans; Immediate-Early Proteins; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthoquinones; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Signal Transduction; Time Factors; Transfection; Tyrosine | 2005 |
Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anoikis; Breast Neoplasms; CSK Tyrosine-Protein Kinase; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 1; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Tyrosine | 2005 |
PKCdelta and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells.
Topics: Anisomycin; Breast Neoplasms; Enzyme Activation; Female; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Oligonucleotides, Antisense; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Kinases; Protein Synthesis Inhibitors; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tyrosine | 2005 |
PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells.
Topics: Amino Acids; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Immunologic Factors; Ligands; Male; Melanoma; Methionine; Phenylalanine; PPAR gamma; Prostaglandin D2; Prostatic Neoplasms; Thiazolidinediones; Tyrosine | 2006 |
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Breast Neoplasms; Calorimetry; Cell Cycle Proteins; Crystallography, X-Ray; DNA Damage; DNA-Binding Proteins; Escherichia coli; Glutamic Acid; Glutamine; Glutathione Transferase; Histones; Humans; Models, Molecular; Models, Statistical; Molecular Sequence Data; Nuclear Proteins; Peptides; Phosphates; Phosphopeptides; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Trans-Activators; Tyrosine | 2005 |
Evaluation of potential Stat3-regulated genes in human breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; Male; Mice; Mice, Nude; Middle Aged; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Phosphorylation; Proto-Oncogene Mas; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2005 |
Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells.
Topics: Anaerobiosis; Animals; Breast Neoplasms; Cell Hypoxia; Chlorocebus aethiops; COS Cells; Cyclin D1; Deferoxamine; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 2; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Serine; Tumor Cells, Cultured; Tyrosine | 2005 |
Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis.
Topics: Animals; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cells, Cultured; Chickens; DNA; Endothelins; ErbB Receptors; Fibroblasts; Growth Hormone; Humans; Immunoprecipitation; Lysophospholipids; Mice; Mice, Inbred C3H; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); S Phase; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2005 |
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Topics: Benzamides; beta-Galactosidase; Breast Neoplasms; Cellular Senescence; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Histone Deacetylase Inhibitors; Humans; Insulin-Like Growth Factor I; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthols; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Sirtuin 1; Sirtuins; Tumor Cells, Cultured; Tyrosine | 2006 |
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.
Topics: Agar; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Binding Sites; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Gene Deletion; Insulin Receptor Substrate Proteins; Mice; Mutation; Neurons; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pol1 Transcription Initiation Complex Proteins; Receptor, IGF Type 1; Ribosomes; RNA; RNA, Ribosomal; Serine; Signal Transduction; Time Factors; Transfection; Tyrosine | 2006 |
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Animals, Newborn; Astrocytes; Brain; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cells, Cultured; Disease Progression; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Fluorescent Antibody Technique, Indirect; Genetic Vectors; HeLa Cells; Humans; Immunoprecipitation; Microscopy, Fluorescence; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Peptides; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; RNA Interference; RNA-Binding Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 2005 |
Synthesis and biodistribution of (11)C-GW7845, a positron-emitting agonist for peroxisome proliferator-activated receptor-{gamma}.
Topics: Animals; Breast Neoplasms; Carbon Radioisotopes; Female; Isotope Labeling; Male; Metabolic Clearance Rate; Mice; Mice, SCID; Organ Specificity; Oxazoles; Positron-Emission Tomography; PPAR gamma; Radiopharmaceuticals; Tissue Distribution; Tyrosine | 2005 |
Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients.
Topics: Breast Neoplasms; Cell Line, Tumor; Disease-Free Survival; Female; Humans; Immunoassay; Luminescent Measurements; Phosphorylation; Prognosis; Receptor, ErbB-2; Tyrosine | 2006 |
Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis.
Topics: Alkenes; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphatic Metastasis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53; Tyrosine; Vascular Endothelial Growth Factor C | 2006 |
Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.
Topics: Amino Acid Motifs; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; GRB2 Adaptor Protein; Humans; Models, Molecular; Oligopeptides; Peptides, Cyclic; Phosphorylation; Protein Binding; Receptor, ErbB-2; src Homology Domains; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2006 |
Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Disulfides; Dose-Response Relationship, Drug; Female; Histone Deacetylase Inhibitors; Humans; Micronesia; Porifera; PPAR gamma; Tyrosine | 2006 |
Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors.
Topics: Animals; Breast Neoplasms; Carcinoma; Cell Line, Transformed; Cell Line, Tumor; Cells, Cultured; Clone Cells; Female; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 2006 |
A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Colchicine; Cytochalasin D; Cytoskeleton; Epidermal Growth Factor; Humans; Kinesins; Microtubules; Phosphorylation; STAT5 Transcription Factor; Tubulin; Tyrosine | 2006 |
Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain.
Topics: Breast Neoplasms; Cell Line, Tumor; DNA Replication; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunoprecipitation; Mutation; Phosphorylation; STAT5 Transcription Factor; Tyrosine | 2006 |
Positive expression of E-cadherin suppresses cell adhesion to fibronectin via reduction of alpha5beta1 integrin in human breast carcinoma cells.
Topics: beta Catenin; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; Extracellular Matrix; Female; Fibronectins; Gene Expression Profiling; Humans; Integrin alpha5beta1; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Cells, Cultured; Tyrosine | 2006 |
Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Immunohistochemistry; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oncogene Proteins v-erbB; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, Progesterone; Tyrosine; Up-Regulation | 2006 |
A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities.
Topics: Alleles; Apoptosis; Breast Neoplasms; Caseins; Cell Nucleus; Cells, Cultured; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Kidney; Male; Ovarian Neoplasms; Phosphorylation; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Transport; Receptor, ErbB-4; STAT5 Transcription Factor; Transcription, Genetic; Transcriptional Activation; Tumor Suppressor Proteins; Tyrosine | 2007 |
EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; ErbB Receptors; Humans; Indoles; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 2007 |
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.
Topics: Amino Acid Sequence; Apoptosis; Arginine; Binding Sites; Breast Neoplasms; Carcinoma; Cells, Cultured; Codon; Conserved Sequence; Female; Gene Expression Regulation; Homozygote; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Polymorphism, Genetic; Proline; Repressor Proteins; Tumor Suppressor Protein p53; Tyrosine | 2006 |
Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Aged, 80 and over; Aldehydes; Base Pair Mismatch; Breast Neoplasms; Carrier Proteins; Deoxyguanosine; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Middle Aged; Nuclear Proteins; Oxidative Stress; Tyrosine | 2006 |
Urokinase receptor primes cells to proliferate in response to epidermal growth factor.
Topics: Animals; Autocrine Communication; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphorylation; Plasminogen; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Small Interfering; STAT5 Transcription Factor; Tyrosine; Urokinase-Type Plasminogen Activator | 2007 |
Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines.
Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; ErbB Receptors; Genetic Therapy; Humans; Mice; Mutation; Neoplastic Stem Cells; Phosphorylation; Receptor, ErbB-4; Retroviridae; Signal Transduction; Tumor Suppressor Proteins; Tyrosine | 2006 |
MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines.
Topics: Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Receptor, ErbB-2; Signal Transduction; Tyrosine | 2007 |
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.
Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Adhesion; Cell Proliferation; Chlorocebus aethiops; COS Cells; GRB2 Adaptor Protein; Hepatocyte Growth Factor; Humans; Integrin beta4; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Tyrosine | 2006 |
c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function.
Topics: Animals; Breast Neoplasms; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Female; Fibroblasts; Humans; Mice; Multiprotein Complexes; Neuregulin-1; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; src-Family Kinases; Tyrosine | 2007 |
Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.
Topics: Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Nucleus; Cell Survival; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; fas Receptor; Fatty Acid Synthases; Female; Flow Cytometry; Genes, erbB-2; Humans; Immunoprecipitation; Naphthoquinones; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Stimulation, Chemical; Translocation, Genetic; Tyrosine | 2007 |
Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Membrane Permeability; Cell Transformation, Neoplastic; Humans; Microtubules; Mitochondria; Paclitaxel; Phosphorylation; Protein Processing, Post-Translational; Tubulin Modulators; Tyrosine | 2007 |
Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase.
Topics: Alanine; Amino Acid Substitution; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Activation; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Green Fluorescent Proteins; Humans; Immunoprecipitation; MAP Kinase Signaling System; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; RNA, Small Interfering; src-Family Kinases; Transfection; Tyrosine | 2007 |
p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Hormonal; Breast Neoplasms; Case-Control Studies; Female; Humans; Neoplasm Recurrence, Local; Phosphoproteins; Phosphorylation; Protein Isoforms; Receptors, Estrogen; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tamoxifen; Tyrosine | 2006 |
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Drug Resistance, Neoplasm; Feedback, Physiological; Female; Humans; Phosphorylation; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Tamoxifen; Tyrosine | 2007 |
Crosstalk between EGFR and extranuclear steroid receptors.
Topics: Androgen Receptor Antagonists; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fulvestrant; Humans; Male; Phosphorylation; Prostatic Neoplasms; Receptor Cross-Talk; Receptors, Androgen; Receptors, Steroid; Signal Transduction; src-Family Kinases; Tyrosine; Up-Regulation | 2006 |
Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; Mammary Neoplasms, Experimental; Mice; Phosphorylation; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Small Interfering; Tamoxifen; Tyrosine | 2007 |
The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; BALB 3T3 Cells; Breast Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Activation; Fibroblasts; Humans; Mice; Mitogen-Activated Protein Kinase 7; NIH 3T3 Cells; Phosphorylation; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT3 Transcription Factor; Tyrosine | 2007 |
Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Histone Acetyltransferases; Humans; Immunoprecipitation; Nuclear Receptor Coactivator 3; Phosphorylation; Receptor, ErbB-3; Receptor, Platelet-Derived Growth Factor beta; RNA, Small Interfering; Signal Transduction; Trans-Activators; Tyrosine | 2007 |
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
Topics: Adult; Age of Onset; Aged; Asian People; Black or African American; Breast Neoplasms; Case-Control Studies; Checkpoint Kinase 2; DNA Mutational Analysis; DNA, Complementary; Female; Gene Frequency; Genetic Predisposition to Disease; Germ-Line Mutation; Hawaii; Hispanic or Latino; Histidine; Humans; Isoleucine; Leucine; Male; Middle Aged; Mutation; Mutation, Missense; Predictive Value of Tests; Proline; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Risk Assessment; Risk Factors; Threonine; Tyrosine; United States; White People | 2007 |
S731 in the transactivation domain modulates STAT5b activity.
Topics: Breast Neoplasms; Cell Line, Tumor; Cysteine; Gene Expression Regulation; Humans; Protein Structure, Tertiary; STAT5 Transcription Factor; Transcriptional Activation; Tyrosine | 2007 |
Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation.
Topics: Antioxidants; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Hyaluronic Acid; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Stromal Cells; Tyrosine | 2007 |
Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Female; Genes, Reporter; Humans; I-kappa B Proteins; Kinetics; Luciferases; Models, Molecular; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type I; Nitrogen; Nuclear Magnetic Resonance, Biomolecular; Oxidants; Peroxynitrous Acid; Protein Processing, Post-Translational; Quantum Theory; Radiation, Ionizing; RNA, Small Interfering; Transfection; Tyrosine | 2007 |
A novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; HeLa Cells; Hepatocyte Growth Factor; Humans; Mice; Models, Biological; Phosphorylation; Promoter Regions, Genetic; Recombination, Genetic; src-Family Kinases; STAT3 Transcription Factor; Transcription, Genetic; Transcriptional Activation; Tyrosine | 2007 |
Inhibition of estradiol receptor/Src association and cell growth by an estradiol receptor alpha tyrosine-phosphorylated peptide.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor alpha; Female; Humans; Male; Mice; Molecular Sequence Data; Oligopeptides; Phosphorylation; Prostatic Neoplasms; src-Family Kinases; Tyrosine; Xenograft Model Antitumor Assays | 2007 |
Tyrosine1248-phosphorylated HER2 expression and HER2 gene amplification in female invasive ductal carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Gene Amplification; Genes, erbB-2; Humans; Immunoenzyme Techniques; In Situ Hybridization, Fluorescence; Middle Aged; Phosphorylation; Receptor, ErbB-2; Tyrosine | 2008 |
ShcA signalling is essential for tumour progression in mouse models of human breast cancer.
Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Disease Progression; Female; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Phosphorylation; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 2008 |
Significance of mitochondrial calcium and nitric oxide for apoptosis of human breast cancer cells induced by tamoxifen and etoposide.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Calcium; Cell Line, Tumor; Cytochromes c; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Membrane Potential, Mitochondrial; Mitochondria; Nitric Oxide; Tamoxifen; Time Factors; Tyrosine | 2008 |
S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation.
Topics: Animals; Blotting, Western; Breast Neoplasms; Calcium-Binding Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Down-Regulation; Drug Combinations; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunoblotting; Interleukin-8; Laminin; Mice; Mice, SCID; Neovascularization, Pathologic; Osteoclasts; Osteolysis; Phosphorylation; Proteoglycans; Receptor, ErbB-2; S100 Calcium Binding Protein A7; S100 Proteins; Signal Transduction; Tyrosine | 2008 |
mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Arabidopsis Proteins; Breast Neoplasms; Calcium; Cell Line, Tumor; Cytochromes c; Female; Humans; Immunochemistry; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Transfection; Tyrosine | 2008 |
The calcium sensing receptor: from understanding parathyroid calcium homeostasis to bone metastases.
Topics: Biomarkers, Tumor; Bone Neoplasms; Breast Neoplasms; Calcium; Calcium Signaling; Cloning, Organism; Female; Homeostasis; Humans; Hyperparathyroidism, Primary; Parathyroid Glands; Parathyroid Neoplasms; Receptors, Calcium-Sensing; Tyrosine | 2008 |
Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population.
Topics: 3' Flanking Region; Breast Neoplasms; Cytosine; Female; Humans; Middle Aged; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Prohibitins; Reference Standards; Repressor Proteins; Turkey; Tyrosine | 2008 |
Correlation between tyrosine hydroxylase activity, melanogenesis, and estradiol binding in human melanoma cells.
Topics: Breast Neoplasms; Cell Line; Cytosol; Estradiol; Fibroblasts; Humans; Kinetics; Levodopa; Melanins; Melanoma; Tamoxifen; Tyrosine; Tyrosine 3-Monooxygenase | 1982 |
Estrogen receptor in malignant melanoma: fact or artefact?
Topics: Breast Neoplasms; Catechol Oxidase; Durapatite; Estradiol; Humans; Hydroxyapatites; In Vitro Techniques; Ligands; Melanoma; Models, Biological; Monophenol Monooxygenase; Oxidation-Reduction; Receptors, Estrogen; Tyrosine | 1983 |
Regulation of protein accumulation in cultured cells.
Topics: Animals; Blood; Breast Neoplasms; Cell Line; Cycloheximide; Cytological Techniques; Hormones; Humans; Leucine; Milk; Muscles; Protein Biosynthesis; Proteins; Rats; Tyrosine | 1982 |
Enzymatic and immunohistochemical evaluation of tyrosine phosphorylation in breast cancer specimens.
Topics: Breast; Breast Neoplasms; Cell Membrane; Cytosol; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Paraffin Embedding; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1993 |
MDA-MB-134 breast carcinoma cells overexpress fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands.
Topics: Antibodies; Breast Neoplasms; Cell Division; Female; Fibroblast Growth Factors; Humans; Phosphorylation; Phosphotyrosine; Receptors, Fibroblast Growth Factor; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tyrosine | 1994 |
Oestrogen and epidermal growth factor down-regulate erbB-2 oncogene protein expression in breast cancer cells by different mechanisms.
Topics: Breast Neoplasms; Cell Division; Down-Regulation; Epidermal Growth Factor; Estradiol; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; In Vitro Techniques; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, fos; Glycoproteins; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Kinetics; Neuregulins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Bacterial Toxins; Base Sequence; Breast Neoplasms; Cell Line; Cell Survival; DNA Primers; ErbB Receptors; Exotoxins; Female; Gene Expression; Glycoproteins; Humans; Immunotoxins; Kidney; Kinetics; Leukemia, T-Cell; Lung Neoplasms; Male; Molecular Sequence Data; Neuregulins; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Prostatic Neoplasms; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Rats; Receptor, ErbB-4; Recombinant Fusion Proteins; RNA, Messenger; Tumor Cells, Cultured; Tyrosine; Virulence Factors | 1995 |
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
Topics: 3T3 Cells; Animals; Base Sequence; Breast Neoplasms; Cell Transformation, Neoplastic; DNA Primers; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, erbB; Glycoproteins; Ligands; Mice; Molecular Sequence Data; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Aggregation; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tyrosine | 1995 |
Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
Topics: Animals; Breast Neoplasms; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Multigene Family; Neoplasm Proteins; Nucleopolyhedroviruses; Phosphorylation; Phosphotyrosine; Protein Phosphatase 1; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Receptors, Estrogen; Recombinant Proteins; Spodoptera; Tumor Cells, Cultured; Tyrosine | 1995 |
An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Breast Neoplasms; Cell Line; DNA Probes; Estrogen Antagonists; Female; Humans; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphotyrosine; Protein Conformation; Receptors, Estrogen; Tumor Cells, Cultured; Tyrosine | 1995 |
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; Emodin; Humans; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1995 |
Lysophospholipids activate ovarian and breast cancer cells.
Topics: Breast Neoplasms; Calcium; Cell Division; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Phosphorylation; Protein Kinases; Receptors, Cell Surface; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1995 |
MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo.
Topics: Blotting, Western; Breast Neoplasms; Cell Division; DNA, Neoplasm; Estrogens; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; Neoplasms, Hormone-Dependent; Phosphorylation; Receptor, ErbB-2; Receptors, Estrogen; Sensitivity and Specificity; Tamoxifen; Transfection; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 1995 |
O-phospho-L-tyrosine inhibits cellular growth by activating protein tyrosine phosphatases.
Topics: Breast Neoplasms; Carcinoma, Renal Cell; Cell Death; Cell Division; Doxorubicin; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Etoposide; Humans; Kidney Neoplasms; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; S Phase; Sensitivity and Specificity; Tumor Cells, Cultured; Tyrosine | 1993 |
Exogenous phosphotyrosine modulates epidermal growth factor receptor tyrosine phosphorylation.
Topics: Breast Neoplasms; Cell Division; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1993 |
Role of intracellular Ca2+ in the epidermal growth factor induced inhibition of protein tyrosine phosphatase activity in a breast cancer cell line.
Topics: Breast Neoplasms; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1993 |
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
Topics: Alkaloids; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Growth Inhibitors; Humans; In Vitro Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Time Factors; Tumor Cells, Cultured; Tyrosine | 1993 |
Pretreatment with vitamin A inhibits transforming growth factor alpha stimulation of human mammary carcinoma cells.
Topics: Breast Neoplasms; Cell Division; ErbB Receptors; Female; Gene Expression; Humans; In Vitro Techniques; Phosphotyrosine; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Vitamin A | 1993 |
Standardization of an enzyme-linked immunosorbent assay for the determination of protein tyrosine kinase activity.
Topics: Animals; Breast Neoplasms; Chemistry Techniques, Analytical; Detergents; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Serum Albumin, Bovine; Spleen; Tissue Extracts; Trichloroacetic Acid; Tyrosine | 1993 |
Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells.
Topics: Breast Neoplasms; Estradiol; Female; Humans; Immunoblotting; Phosphopyruvate Hydratase; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); Tumor Cells, Cultured; Tyrosine | 1993 |
Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Differentiation; CHO Cells; Chromatography; Cricetinae; ErbB Receptors; Glycoproteins; Humans; Liver Neoplasms; Molecular Sequence Data; Molecular Weight; Neuregulins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, ErbB-4; Receptors, Cell Surface; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1993 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Cross Reactions; Female; Gene Expression; Humans; Immunohistochemistry; Mice; Molecular Sequence Data; Phosphorylation; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Bioactive synthetic peptide of NDF/heregulin.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; CHO Cells; Cricetinae; Glycoproteins; Humans; Molecular Sequence Data; Neuregulins; Peptides; Phosphorylation; Protein Folding; Tumor Cells, Cultured; Tyrosine | 1995 |
HER4 receptor activation and phosphorylation of Shc proteins by recombinant heregulin-Fc fusion proteins.
Topics: Amino Acid Sequence; Animals; Base Sequence; Breast Neoplasms; Cells, Cultured; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Humans; Immunoglobulin Fc Fragments; Intercellular Adhesion Molecule-1; Molecular Sequence Data; Neuregulins; Phosphorylation; Protein Binding; Receptor, ErbB-4; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Thrombin; Tyrosine | 1995 |
Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Breast Neoplasms; Humans; Membrane Glycoproteins; Mice; Molecular Sequence Data; Mucin-1; Mucins; Neoplasm Proteins; Phosphorylation; Receptors, Cytokine; Sequence Homology, Amino Acid; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
NDF/heregulin stimulates the phosphorylation of Her3/erbB3.
Topics: Animals; Breast Neoplasms; Carcinoma; CHO Cells; Cricetinae; ErbB Receptors; Female; Glycoproteins; Humans; Neuregulins; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-3; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Differential signal transduction of epidermal-growth-factor receptors in hormone-dependent and hormone-independent human breast cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Cell Division; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Fluorescein-5-isothiocyanate; Genes, fos; Humans; Neoplasms, Hormone-Dependent; Phosphorylation; Proto-Oncogene Mas; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element.
Topics: Amino Acid Sequence; Animals; Base Sequence; Breast Neoplasms; Chromatography, Affinity; Cytosol; DNA-Binding Proteins; Estradiol; Female; Humans; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligonucleotide Probes; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Receptors, Estrogen; Recombinant Proteins; Spodoptera; Transfection; Tumor Cells, Cultured; Tyrosine; Xenopus | 1995 |
Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2.
Topics: Base Sequence; Breast; Breast Neoplasms; Cell Division; Epidermal Growth Factor; Female; Gene Amplification; Genes, erbB-2; Glycoproteins; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Neuregulins; Phosphorylation; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1996 |
Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Amino Acid Sequence; Breast Neoplasms; Carrier Proteins; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Glycoproteins; Humans; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neuregulin-1; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; src Homology Domains; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1996 |
Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities.
Topics: Animals; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Glycoproteins; Humans; In Vitro Techniques; Neuregulins; Peptides; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Tumor Cells, Cultured; Tyrosine | 1996 |
Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplifi
Topics: Androstadienes; Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Blotting, Western; Breast Neoplasms; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Glycoproteins; Humans; Insulin-Like Growth Factor I; Mitogens; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Cell cycle expression of p53 protein, c-Myc gene product and tyrosine-phosphorylation level determined by image analysis in human breast cancer cells.
Topics: Antibody Specificity; Breast Neoplasms; Cell Cycle; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Image Cytometry; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrosine | 1996 |
Involvement of SHC, GRB2, SOS and RAS in prolactin signal transduction in mammary epithelial cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Breast Neoplasms; Cell Division; Cell Line; Epithelium; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, ras; GRB2 Adaptor Protein; Humans; Janus Kinase 2; Mammary Glands, Animal; Membrane Proteins; Mice; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptors, Prolactin; Shc Signaling Adaptor Proteins; Signal Transduction; Son of Sevenless Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine | 1996 |
An enzyme-linked immunosorbent assay for the determination of src-family tyrosine kinase activity in breast cancer.
Topics: Animals; Biological Assay; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Polyglutamic Acid; Rats; Reproducibility of Results; Sensitivity and Specificity; Spleen; src-Family Kinases; Tyrosine | 1996 |
Epidermal growth factor-regulated signal transduction in hormone dependent and independent breast cancer.
Topics: Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phosphorylation; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1996 |
Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cells.
Topics: Breast Neoplasms; Cell Division; Down-Regulation; Female; Fibronectins; Genes, erbB-2; Humans; Laminin; Neoplasm Proteins; Phosphorylation; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1996 |
Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Breast Neoplasms; CHO Cells; Cricetinae; Estradiol; Histone Acetyltransferases; Humans; Molecular Sequence Data; Mutation; Nuclear Receptor Coactivator 1; Phenotype; Phosphorylation; Receptors, Estrogen; Recombinant Proteins; Serine; Structure-Activity Relationship; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1996 |
Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines.
Topics: Breast Neoplasms; Cortactin; Cyclin D1; Cyclins; Female; Gene Amplification; Humans; Microfilament Proteins; Neoplasm Proteins; Oncogene Proteins; Phosphorylation; RNA, Messenger; Tumor Cells, Cultured; Tyrosine | 1996 |
Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Epithelium; Female; GPI-Linked Proteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Mammary Glands, Animal; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinase 1; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases; src Homology Domains; Tumor Cells, Cultured; Tyrosine | 1997 |
Standardized uptake value and quantification of metabolism for breast cancer imaging with FDG and L-[1-11C]tyrosine PET.
Topics: Blood Glucose; Breast; Breast Neoplasms; Carbon Radioisotopes; Carcinoma, Ductal, Breast; Deoxyglucose; Female; Fibrocystic Breast Disease; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Tomography, Emission-Computed; Tyrosine | 1997 |
Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibody Specificity; BRCA1 Protein; Breast Neoplasms; Cell Cycle; Cell Transformation, Neoplastic; Humans; Mice; Molecular Sequence Data; Phenotype; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 1997 |
Characterization of peptides that bind the tumor-associated Thomsen-Friedenreich antigen selected from bacteriophage display libraries.
Topics: alpha-Fetoproteins; Amino Acid Sequence; Animals; Antigens, Neoplasm; Antigens, Tumor-Associated, Carbohydrate; Asialoglycoproteins; Binding, Competitive; Breast Neoplasms; Carcinoma; Cell Aggregation; Fetuins; Humans; Lectins; Melanoma; Mice; Molecular Sequence Data; Peanut Agglutinin; Peptide Library; Peptides; Protein Binding; Sequence Homology, Amino Acid; Serum Albumin, Bovine; Tumor Cells, Cultured; Tyrosine | 1997 |
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Humans; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Binding; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1997 |
Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation.
Topics: Breast Neoplasms; Cell Division; Down-Regulation; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Mutagenesis, Site-Directed; Phosphopeptides; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, ErbB-2; src Homology Domains; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1998 |
Intercellular and intracellular events following the MHC-unrestricted TCR recognition of a tumor-specific peptide epitope on the epithelial antigen MUC1.
Topics: Amino Acid Sequence; Biological Transport; Breast Neoplasms; Calcium; CD58 Antigens; Cell Nucleus; DNA-Binding Proteins; Epitopes; Extracellular Space; Histocompatibility Antigens Class I; HLA Antigens; Humans; Intercellular Adhesion Molecule-1; Intracellular Fluid; Lymphocyte Activation; Microspheres; Molecular Sequence Data; Mucin-1; NFATC Transcription Factors; Nuclear Proteins; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic; Transcription Factors; Tumor Cells, Cultured; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1998 |
The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin.
Topics: Animals; Antibodies, Monoclonal; Betacellulin; Binding Sites; Breast Neoplasms; Cell Differentiation; Cell Division; Dimerization; Epidermal Growth Factor; ErbB Receptors; Female; Growth Substances; Hematopoietic Stem Cells; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Mice; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1998 |
Prolactin activates Stat1 but does not antagonize Stat1 activation and growth inhibition by type I interferons in human breast cancer cells.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Drug Therapy, Combination; Female; Humans; Immunoblotting; Interferon Type I; Phosphorylation; Prolactin; Rabbits; Signal Transduction; STAT1 Transcription Factor; STAT2 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1998 |
Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines.
Topics: alpha Catenin; beta Catenin; Blotting, Northern; Breast Neoplasms; Butyrates; Butyric Acid; Cadherins; Cell Adhesion; Cell Division; Cytoskeletal Proteins; Female; Humans; Leucine; Mucin-1; Oligonucleotides, Antisense; Phosphorylation; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1998 |
Association of PKC delta and active Src in PMA-treated MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Extracts; Cell Fractionation; Enzyme Activation; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Isoenzymes; Mitogens; Molecular Chaperones; Neoplasm Proteins; Oncogene Protein pp60(v-src); Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tyrosine | 1998 |
The discoidin domain receptor tyrosine kinases are activated by collagen.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biocompatible Materials; Breast Neoplasms; Carbohydrate Metabolism; Carbohydrates; Collagen; Collagenases; Discoidin Domain Receptors; Drug Combinations; Extracellular Matrix Proteins; Fibroblasts; Fibrosarcoma; Hot Temperature; Humans; Kidney; Kinetics; Laminin; Ligands; Matrix Metalloproteinase 1; Mice; Molecular Sequence Data; Pepsin A; Phosphorylation; Protein Denaturation; Protein Structure, Tertiary; Proteoglycans; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Tendons; Tumor Cells, Cultured; Tyrosine | 1997 |
Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Transformed; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Ribosomal Protein S6 Kinases; Tumor Cells, Cultured; Tyrosine | 1998 |
Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Breast Neoplasms; Female; Humans; Phosphorylation; Proteins; Receptor, ErbB-2; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine | 1998 |
Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes.
Topics: Breast Neoplasms; CDC2-CDC28 Kinases; cdc25 Phosphatases; Cell Cycle Proteins; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclins; Estradiol; Estrogen Antagonists; Female; Humans; Microtubule-Associated Proteins; Phosphorylation; Polychlorinated Dibenzodioxins; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Receptors, Aryl Hydrocarbon; Retinoblastoma Protein; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Tyrosine | 1998 |
Identification of tyrosine phosphorylated adhesion proteins in human cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specificity; Breast Neoplasms; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Female; Humans; Mice; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 1998 |
Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions.
Topics: 3T3 Cells; Actins; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Breast Neoplasms; Cell Membrane; Cell Transformation, Neoplastic; COS Cells; Cytoskeletal Proteins; Female; Homeodomain Proteins; Humans; LIM Domain Proteins; Mice; Microfilament Proteins; Molecular Sequence Data; Neoplasm Proteins; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); src Homology Domains; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 1998 |
Gap junctional communication and the tyrosine phosphorylation of connexin 43 in interaction between breast cancer and endothelial cells.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Adhesion; Cell Line; Connexin 43; Endothelium, Vascular; Female; Gap Junctions; Humans; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 1998 |
Role of IRS-1 signaling in insulin-induced modulation of estrogen receptors in breast cancer cells.
Topics: Breast Neoplasms; Culture Media, Conditioned; Down-Regulation; Estradiol; Growth Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Phosphoproteins; Phosphorylation; Protein Binding; Receptor Cross-Talk; Receptor, Insulin; Receptors, Estrogen; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1998 |
Decreased tyrosine phosphorylation of focal adhesion kinase after estradiol treatment of MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Dimethyl Sulfoxide; Estradiol; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Tyrosine | 1998 |
Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Adhesion Molecules; Cytoskeletal Proteins; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Retinoic Acid; Signal Transduction; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1999 |
Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells.
Topics: Breast; Breast Neoplasms; Cell Cycle; Epithelial Cells; Female; G1 Phase; G2 Phase; Humans; Mitosis; Nocodazole; Paclitaxel; Phosphorylation; Receptor, ErbB-2; Resting Phase, Cell Cycle; src Homology Domains; Stem Cells; Tumor Cells, Cultured; Tyrosine | 1999 |
Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cell Movement; Chemotaxis; Collagen; Cytoskeletal Proteins; Drug Combinations; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gelatinases; Humans; Laminin; Lysophospholipids; Matrix Metalloproteinase 2; Metalloendopeptidases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Sphingosine; Tumor Cells, Cultured; Tyrosine | 1999 |
Met-HGF/SF mediates growth arrest and differentiation in T47D breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Caseins; Cell Cycle; Cell Differentiation; Cell Division; DNA; Flow Cytometry; Hepatocyte Growth Factor; Humans; In Situ Hybridization, Fluorescence; Lactalbumin; Methionine; Microscopy, Fluorescence; Phenotype; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 1999 |
Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells.
Topics: Breast Neoplasms; Endopeptidases; Humans; Hydroxamic Acids; Metalloendopeptidases; Phenylalanine; Phosphorylation; Protease Inhibitors; Receptor, ErbB-2; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Tyrosine; Vanadates | 1999 |
Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Aggregation; ErbB Receptors; Female; Glycoproteins; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Tumor Cells, Cultured; Tyrosine | 1999 |
Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell dea
Topics: Antibodies; Breast Neoplasms; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Carcinoma, Squamous Cell; Cell Death; Cell Division; DNA, Antisense; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phosphorylation; Protein Kinases; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1999 |
The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the effect on the human prolactin receptor.
Topics: Animals; Breast Neoplasms; Cell Division; CHO Cells; Cricetinae; DNA-Binding Proteins; Human Growth Hormone; Humans; Janus Kinase 2; Mice; Milk Proteins; Molecular Weight; Mutation; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Prolactin; Recombinant Proteins; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Zinc | 1999 |
E-cadherin regulates the function of the EphA2 receptor tyrosine kinase.
Topics: Breast Neoplasms; Cadherins; Cell Adhesion; Cell Division; Ephrin-A2; Epithelial Cells; Humans; Phosphorylation; Transcription Factors; Tumor Cells, Cultured; Tyrosine | 1999 |
Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells.
Topics: Binding Sites; Breast Neoplasms; Female; Glutathione; Humans; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Protein Processing, Post-Translational; S-Nitrosoglutathione; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrosine | 2000 |
RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion.
Topics: Breast Neoplasms; Female; Focal Adhesion Kinase 2; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Humans; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neuregulin-1; Nuclear Proteins; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; ras-GRF1; Receptor, ErbB-2; Repressor Proteins; Tyrosine | 2000 |
Autocrine human growth hormone enhancement of human mammary carcinoma cell spreading is Jak2 dependent.
Topics: Actins; Autocrine Communication; Breast Neoplasms; Carcinoma; Cell Adhesion; Enzyme Inhibitors; Female; Growth Hormone; Hormone Antagonists; Human Growth Hormone; Humans; Janus Kinase 2; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Recombinant Proteins; Tissue Distribution; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2000 |
Cell death induced by TNF or serum starvation is independent of ErbB receptor signaling in MCF-7 breast carcinoma cells.
Topics: Breast Neoplasms; Cell Count; Cell Death; Cell Size; Culture Media, Serum-Free; ErbB Receptors; Female; Humans; Ligands; Neuregulin-1; Phosphorylation; Receptor, ErbB-2; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Oncostatin M suppresses EGF-mediated protein tyrosine phosphorylation in breast cancer cells.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Division; Culture Media; Cytokines; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Inflammation Mediators; Oncostatin M; Peptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Time Factors; Tumor Cells, Cultured; Tyrosine | 2000 |
Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion.
Topics: Breast Neoplasms; Buffers; Cell Adhesion; Culture Media, Conditioned; Cytoplasm; Detergents; Female; Humans; Mucin-1; Ovarian Neoplasms; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Structure, Tertiary; Tumor Cells, Cultured; Tyrosine | 2000 |
Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer.
Topics: Adaptor Proteins, Signal Transducing; Breast Neoplasms; Cell Division; Female; GRB2 Adaptor Protein; Humans; Janus Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptor, ErbB-2; Tyrosine | 2000 |
An anti-oncogenic role for decorin. Down-regulation of ErbB2 leads to growth suppression and cytodifferentiation of mammary carcinoma cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Differentiation; Cell Division; Cell Separation; Coculture Techniques; Decorin; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; ErbB Receptors; Extracellular Matrix Proteins; Flow Cytometry; Humans; Immunohistochemistry; Kinetics; Leucine; Mice; Phenotype; Phosphorylation; Precipitin Tests; Proteoglycans; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 2000 |
Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antibodies; Biomarkers, Tumor; Breast Neoplasms; Female; Follow-Up Studies; Humans; Immunohistochemistry; Middle Aged; Multivariate Analysis; Phosphorylation; Prognosis; Receptor, ErbB-2; Retrospective Studies; Survival Analysis; Treatment Outcome; Tyrosine | 2000 |
Growth inhibition and protein tyrosine phosphorylation in MCF 7 breast cancer cells by a novel K vitamin.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Naphthalenes; Phosphorylation; Quinones; Tumor Cells, Cultured; Tyrosine; Vitamin K | 2000 |
Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Flavonoids; Humans; Immunoblotting; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Precipitin Tests; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2000 |
The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor.
Topics: Apoptosis; Breast Neoplasms; Carcinoma; CCAAT-Enhancer-Binding Proteins; Cell Adhesion; Cell Division; Collagen; DNA-Binding Proteins; ets-Domain Protein Elk-1; Female; Human Growth Hormone; Humans; Janus Kinase 2; Milk Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; STAT5 Transcription Factor; Trans-Activators; Transcription Factor CHOP; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 2001 |
Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Breast Neoplasms; Cell Division; Cell Movement; DNA-Binding Proteins; Enzyme Activation; ErbB Receptors; Humans; Interleukin-6; Intracellular Signaling Peptides and Proteins; Janus Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Oncostatin M; Peptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor, ErbB-2; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2001 |
Alkyl-lysophospholipid 1-O-octadecyl-2-O-methyl- glycerophosphocholine induces invasion through episialin-mediated neutralization of E-cadherin in human mammary MCF-7 cells in vitro.
Topics: Antibodies, Monoclonal; beta Catenin; Biotinylation; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Aggregation; Cell Membrane; Cell Survival; Collagen; Cytoskeletal Proteins; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoblotting; Microscopy, Confocal; Microscopy, Fluorescence; Mucin-1; Neoplasm Invasiveness; Phenotype; Phosphatidylcholines; Phospholipid Ethers; Phosphorylation; Precipitin Tests; Protein Binding; Radioimmunoassay; Signal Transduction; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2001 |
Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability.
Topics: Active Transport, Cell Nucleus; beta Catenin; Breast Neoplasms; Cell Adhesion; Cell Membrane; Cell Movement; Cell Nucleus; Cytoskeletal Proteins; Cytosol; DNA-Binding Proteins; Epithelial Cells; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Guanine Nucleotide Exchange Factors; Humans; Lymphoid Enhancer-Binding Factor 1; Microscopy, Fluorescence; Neuregulin-1; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Biosynthesis; Proteins; Signal Transduction; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2001 |
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Dimerization; Female; Humans; Immunohistochemistry; Middle Aged; Prognosis; Tubulin; Tyrosine | 2001 |
Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor.
Topics: Adaptor Proteins, Signal Transducing; Breast Neoplasms; Cell Division; Cyclization; Drug Design; Enzyme-Linked Immunosorbent Assay; GRB2 Adaptor Protein; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Peptides; Protein Binding; Proteins; Receptors, Drug; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 2001 |
Estradiol increases IRS-1 gene expression and insulin signaling in breast cancer cells.
Topics: Analysis of Variance; Breast Neoplasms; Estradiol; Gene Expression Regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2001 |
Specific amino acid deficiency alters the expression of genes in human melanoma and other tumor cell lines.
Topics: Blotting, Western; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Melanoma; Mitogen-Activated Protein Kinase Kinases; Phenylalanine; Phosphorylation; Prostatic Neoplasms; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tyrosine | 2001 |
The linkage between beta1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1 integrin in normal and cancerous human breast cells.
Topics: Actin Cytoskeleton; Actinin; Actins; Amino Acid Sequence; Breast; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epithelial Cells; Female; Humans; Integrin beta1; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Serine; Threonine; Tumor Cells, Cultured; Tyrosine | 2001 |
Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.
Topics: Breast Neoplasms; Cell Division; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Female; Humans; Oncogene Proteins v-erbB; Phosphorylation; Quinazolines; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2002 |
Epidermal growth factor receptor and tyrosine phosphorylation of estrogen receptor.
Topics: Animals; Breast Neoplasms; Cell Death; Cell Division; COS Cells; Epidermal Growth Factor; ErbB Receptors; Estrogens; Female; Humans; Phosphorylation; Receptors, Estrogen; Response Elements; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2001 |
ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas.
Topics: Adenocarcinoma; Animals; beta Catenin; Breast Neoplasms; Cytoskeletal Proteins; ErbB Receptors; Humans; Immunoblotting; Immunohistochemistry; Ligands; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Microscopy, Fluorescence; Phosphorylation; Precipitin Tests; Protein Binding; Proto-Oncogene Proteins; Receptor, ErbB-2; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Wnt Proteins; Wnt1 Protein; Zebrafish Proteins | 2002 |
Acceptability and tolerance of a low tyrosine and phenylalanine diet in patients with advanced cancer -- a pilot study.
Topics: Adult; Aged; Breast Neoplasms; Depression; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nutritional Status; Phenylalanine; Pilot Projects; Quality of Life; Treatment Outcome; Tryptophan; Tyrosine | 2002 |
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast; Breast Neoplasms; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cells, Cultured; Cyclin B; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Fragmentation; Drug Resistance, Neoplasm; Female; Humans; In Situ Nick-End Labeling; Mitosis; Paclitaxel; Phosphorylation; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 2002 |
Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Blotting, Western; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Paclitaxel; Protein Isoforms; Tubulin; Tumor Cells, Cultured; Tyrosine | 2002 |
A new human antitumor immunoreagent specific for ErbB2.
Topics: Animals; Antibodies, Monoclonal; Bacteriophages; Breast Neoplasms; Cell Division; Cloning, Molecular; Endocytosis; Female; Humans; Immunoglobulin Variable Region; Mice; Phosphorylation; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 2002 |
Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration.
Topics: Blotting, Western; Breast Neoplasms; Cell Movement; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Down-Regulation; Female; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Megakaryocytes; Neoplasm Invasiveness; Neuregulin-1; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, ErbB-2; Recombinant Proteins; Signal Transduction; src-Family Kinases; Transfection; Tumor Cells, Cultured; Tyrosine | 2002 |
Tyrosine phosphatase inhibition permits analysis of signal transduction complexes in p185HER2/neu-overexpressing human tumor cells.
Topics: Amino Acid Sequence; Blotting, Western; Breast Neoplasms; Enzyme Activation; Female; Gene Expression; GTPase-Activating Proteins; Humans; Ovarian Neoplasms; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor, ErbB-2; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1992 |
Monoclonal antibodies against the extracellular domain of the erbB-2 receptor function as partial ligand agonists.
Topics: Antibodies, Monoclonal; Blotting, Western; Breast Neoplasms; Flow Cytometry; Humans; Ligands; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Thymidine; Tumor Cells, Cultured; Tunicamycin; Tyrosine | 1992 |
Receptor-induced phosphorylation by mammary-derived growth factor 1 in mammary epithelial cell lines.
Topics: Blotting, Western; Breast; Breast Neoplasms; Cell Line; Cross-Linking Reagents; Epithelial Cells; Epithelium; ErbB Receptors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Receptors, Growth Factor; Tumor Cells, Cultured; Tyrosine | 1992 |
Disulfide-linked and noncovalent dimers of p185HER-2 in human breast carcinoma cells.
Topics: Alkylating Agents; Antibodies; Breast Neoplasms; Disulfides; Humans; Iodoacetates; Iodoacetic Acid; Oncogene Proteins, Viral; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1992 |
Effects of epidermal growth factor and analogues of luteinizing hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Autoradiography; Breast Neoplasms; Cell Line; Colonic Neoplasms; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Humans; Kinetics; Lung Neoplasms; Membrane Proteins; Molecular Sequence Data; Pancreatic Neoplasms; Phosphorus Radioisotopes; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Somatostatin; Triptorelin Pamoate; Tyrosine | 1991 |
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.
Topics: Antibodies; Breast Neoplasms; Gene Expression; Humans; Immunoblotting; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Stimulation of growth of human breast cancer cells (T47D) by platelet derived growth factor.
Topics: Annexins; Antibodies; Breast Neoplasms; Calcium-Binding Proteins; Cell Division; Humans; Immunoglobulin Fab Fragments; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Oncogenic potential of erbB-2 in human mammary epithelial cells.
Topics: Animals; Breast; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; DNA; Epithelium; Gene Expression; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine | 1991 |
Somatostatin receptor imaging with 123I-Tyr3-Octreotide.
Topics: Autoradiography; Brain Neoplasms; Breast Neoplasms; Humans; Iodine Radioisotopes; Multiple Endocrine Neoplasia; Octreotide; Pancreatic Neoplasms; Radiography; Radionuclide Imaging; Receptors, Neurotransmitter; Receptors, Somatostatin; Somatostatin; Tyrosine | 1990 |
Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Line, Transformed; Cell Membrane; Culture Media; Fibroblasts; Genes, ras; Hematopoietic Stem Cells; Humans; Mitogens; Mitosis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured; Tyrosine | 1989 |
A nonradioactive dot-blot assay for protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Antibodies; Breast Neoplasms; Cell Extracts; Humans; Immunoblotting; Immunohistochemistry; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Kinetics; Membranes, Artificial; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1989 |
Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.
Topics: Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1988 |
Carbon-11 labelled tyrosine to study tumor metabolism by positron emission tomography (PET).
Topics: Animals; Breast Neoplasms; Carbon Radioisotopes; Female; Humans; Liver Neoplasms; Male; Meningeal Neoplasms; Neoplasm Proteins; Neoplasms, Experimental; Rats; Tomography, Emission-Computed; Tyrosine | 1986 |
Comparative metabolic studies on the ovaries of the mice susceptible and resistant to breast cancer.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Breast Neoplasms; DNA; Female; Mice; Ovary; Phosphoric Monoester Hydrolases; RNA; Tyrosine | 1968 |
Transfer RNA species in solid human tumors.
Topics: Albumins; Biopsy; Breast Neoplasms; Carbon Isotopes; Chromatography; HeLa Cells; Humans; Liver; RNA, Neoplasm; RNA, Transfer; Silicon Dioxide; Tritium; Tyrosine | 1971 |
Immunosuppressive effects of L-asparaginase.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Alanine; Antibody Formation; Antigens; Asparaginase; Asparagine; Breast Neoplasms; Carcinoma; Child, Preschool; Female; Glutamates; Hemocyanins; Humans; Hypersensitivity, Delayed; Immunoglobulins; Immunosuppressive Agents; Lectins; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Lysine; Male; Middle Aged; Neoplasms; Osteosarcoma; Tyrosine | 1970 |