tyrosine has been researched along with Amyotrophic Lateral Sclerosis in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.92) | 18.7374 |
| 1990's | 11 (21.15) | 18.2507 |
| 2000's | 17 (32.69) | 29.6817 |
| 2010's | 21 (40.38) | 24.3611 |
| 2020's | 2 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Jang, SM; Kim, H; Kim, S; Ko, HS; Kweon, SH; Lee, KH; Lee, S; Na, CH; Park, H; Ryu, HG | 1 |
| Bandookwala, M; Sengupta, P | 1 |
| Sawada, H | 1 |
| Bagnoli, S; Berti, V; Bessi, V; Braccia, A; Del Mastio, M; Matà, S; Nacmias, B; Piaceri, I; Pignone, AM; Polito, C; Pupi, A; Sorbi, S; Tedde, A | 1 |
| Hashimoto, T; Ihara, R; Iwatsubo, T; Kishino, Y; Kunugi, H; Matsukawa, K; Matsumoto, T; Wakabayashi, T; Watanabe, N | 1 |
| Dardov, VJ; Farrer, LA; Ferry, R; Fraser, PE; Holt, CE; Kaminski Schierle, GS; Kaminski, CF; Klenerman, D; Knowles, T; Lin, JQ; Meadows, W; Miyashita, A; Phillips, EC; Qamar, S; Randle, SJ; Ruggeri, FS; Schmitt-Ulms, G; St George-Hyslop, P; Ströhl, F; Tartaglia, GG; Varela, JA; Vendruscolo, M; Wang, G; Williams, D | 1 |
| Cavallaro, S; D'Agata, V; D'Amico, AG; Federico, C; La Cognata, V; Maugeri, G; Morello, G; Rasà, DM; Saccone, S | 1 |
| Bernreuther, C; Cronin, SJ; Eggan, KC; Glatzel, M; Hanada, R; Hanada, T; Herbst, R; Ichida, J; Kofler, R; Komnenovic, V; Mair, B; Martinez, J; Mimata, H; Minis, A; Orthofer, M; Penninger, JM; Rainer, J; Sato, F; Tamir, I; Wainger, BJ; Weitzer, S; Woolf, CJ; Yaron, A; Yoshimura, A | 1 |
| Barnes, S; Basso, M; Beal, MF; Beckman, JS; Calingasan, NY; Estévez, AG; Feldman, JL; Franco, MC; Grumet, M; Kiaei, M; Ma, TC; Mehl, R; Melero Fernández de Mera, RM; Refakis, CA; Rhoads, TW; Sparrow, NA; Stokes, AL; Ye, Y | 1 |
| Bendotti, C; Biggio, ML; Dyall, SC; Gladman, S; Jayasinghe, M; Malaspina, A; Marino, M; Michael-Titus, A; Pizzasegola, C; Ullah, F; Yip, PK | 1 |
| Assaf, Y; Giladi, E; Gozes, I; Jouroukhin, Y; Ostritsky, R; Pelled, G | 1 |
| Arif, M; Garruto, RM; Grundke-Iqbal, I; Iqbal, K; Kazim, SF | 1 |
| Acab, A; Chiang, BJ; Hsu, CI; Liu, J; Tao, A; Weiss, JH; Wu, R; Yin, HZ; Yu, S | 1 |
| Darovic, S; Gunčar, G; Lee, YB; Prpar Mihevc, S; Rogelj, B; Shaw, CE; Štalekar, M; Župunski, V | 1 |
| Fujita, Y; Furuta, N; Ikeda, M; Ikeda, Y; Ishizawa, K; Makioka, K; Motomura, M; Nagamine, S; Okamoto, K; Shibata, M; Tsukagoshi, S; Yoshimura, S | 1 |
| Clatterbuck-Soper, SF; Jackrel, ME; Mili, S; Shorter, J; Yasuda, K | 1 |
| Basso, M; Bendotti, C; Bonetto, V; Garbelli, S; Mantovani, S; Marinou, K; Mora, G; Nardo, G; Pozzi, S | 1 |
| Barbeito, L; Beckman, JS; Elizondo, V; Horjales, S; Lepanto, P; Marin, M; Martinez-Palma, L; Palacios, F; Sotelo-Silveira, JR | 1 |
| Funakoshi, H; Kadoyama, K; Matsumoto, K; Matsuyama, S; Nakamura, T; Ohya-Shimada, W | 1 |
| Basso, M; Bendotti, C; Bonetto, V; Cantoni, L; Cheroni, C; D'Alessandro, G; De Biasi, S; Estevez, AG; Giordana, MT; Marino, M; Massignan, T; Nardo, G; Salmona, M; Samengo, G; Strong, MJ; Tartari, S | 1 |
| Bernabei, C; Bragato, C; Chiari, A; Gellera, C; Georgoulopoulou, E; Mandrioli, J; Sola, P | 1 |
| Chimelli, L; Higashi, R; Martinez, AM; Martins, SC; Mendonça, DM; Muscara, MN; Neto, VM | 1 |
| Bisogni, G; Conte, A; Del Grande, A; Lattante, S; Luigetti, M; Madia, F; Marangi, G; Sabatelli, M; Zollino, M | 1 |
| Cho, W; Gwag, BJ; Im, DS; Lee, JH; Lee, JK; Lee, YA; Lee, YB; Shin, JH; Springer, JE; Yun, BS | 1 |
| Christie, BR; Foster, JA; Hamadeh, MJ; Ma, X; Tarnopolsky, MA | 1 |
| Chook, YM; Zhang, ZC | 1 |
| Abou-Ajram, C; Ansorge, O; Bentmann, E; Dormann, D; Haass, C; Kremmer, E; Mackenzie, IR; Madl, T; Neumann, M; Tahirovic, S; Valori, CF | 1 |
| Blennow, K; Caidahl, K; Davidsson, P; Persson, LI; Ryberg, H; Söderling, AS | 1 |
| Beal, MF; Calingasan, NY; Chen, J; Kiaei, M; Kipiani, K | 1 |
| Barbeito, AG; Barbeito, L; Beckman, JS; Cassina, P; Castellanos, R; Estévez, AG; Pehar, M; Thompson, JA; Vargas, MR | 1 |
| Choi, DK; Heinecke, JW; Jackson-Lewis, V; Pennathur, S; Perier, C; Przedborski, S; Teismann, P; Tieu, K; Vila, M; Vonsattel, JP; Wu, DC | 1 |
| Calingasan, NY; Flint Beal, M; Kiaei, M; Petri, S; Wille, E | 1 |
| Hong, YH; Kim, HJ; Kim, MJ; Kim, SM; Lee, KW; Park, JH; Park, KS; Sung, JJ | 1 |
| Gordon, P; Lu, J; Mehrazin, M; Mitsumoto, H; Naini, A | 1 |
| Abe, K; Itoyama, Y; Kato, T; Pan, LH; Watanabe, M | 1 |
| Chou, SM; Komai, K; Wang, HS | 1 |
| Chou, SM; Taniguchi, A; Wang, HS | 1 |
| Abe, K; Itoyama, Y; Kato, T; Konno, H; Pan, LH; Watanabe, M | 1 |
| Beal, MF; Becher, MW; Bruijn, LI; Cleveland, DW; Price, DL; Schulz, JB; Wong, PC | 1 |
| Beckman, JS; Crow, JP; Sampson, JB; Thompson, JA; Zhuang, Y | 1 |
| Beal, MF; Brown, RH; Browne, SE; Ferrante, RJ; Kowall, NW; Matthews, RT | 1 |
| Beckman, JS; Crow, JP; Sopper, MM; Strong, MJ; Strong, WL | 1 |
| Barbeito, L; Beckman, JS; Estévez, AG; Manuel, SM; Radi, R; Spear, N | 1 |
| Andreassen, OA; Beal, MF; Bogdanov, MB; Ferrante, RJ; Kaddurah-Daouk, R; Klein, AM; Klivenyi, P; Matthews, RT; Mueller, G; Wermer, M | 1 |
| Abe, T; Ishizaki, E; Isobe, C; Murata, T; Tohgi, H; Yamazaki, K | 1 |
| Cha, CI; Chung, YH; Gurney, ME; Kim, YS; Lee, KW; Shin, CM; Shin, DH | 1 |
| Hamano, T; Hirayama, M; Kuriyama, M; Mitsuma, T; Mutoh, T; Sobue, G; Yamamoto, M | 1 |
| Iwata, M; Komori, T; Sasaki, S; Shibata, N | 1 |
| Halliwell, B; Hyun, D; Jenner, P; Lee, M | 1 |
| Doroudchi, MM; Durham, HD; Figlewicz, DA; Minotti, S | 1 |
| Abe, K; Iwata, M; Sasaki, S; Warita, H | 1 |
| Engel, WK | 1 |
3 review(s) available for tyrosine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biomarkers; Humans; Huntington Disease; Parkinson Disease; Prion Diseases; Tyrosine | 2020 |
Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Tyrosine | 2017 |
Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Death; Cell Survival; Humans; Motor Neurons; Nitrates; Nitric Oxide; Superoxide Dismutase; Tyrosine | 1998 |
49 other study(ies) available for tyrosine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation.
Topics: Amyotrophic Lateral Sclerosis; DNA Helicases; DNA-Binding Proteins; Humans; Neuroblastoma; Phosphorylation; Poly-ADP-Ribose Binding Proteins; Proto-Oncogene Proteins c-abl; RNA Helicases; RNA Recognition Motif Proteins; Tyrosine | 2022 |
Association of the New Variant Tyr424Asp at TBK1 Gene with Amyotrophic Lateral Sclerosis and Cognitive Decline.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; C9orf72 Protein; Cognitive Dysfunction; DNA Mutational Analysis; Female; Fluorodeoxyglucose F18; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Italy; Male; Mental Status and Dementia Tests; Middle Aged; Mutation; Neuropsychological Tests; Positron-Emission Tomography; Protein Serine-Threonine Kinases; Tyrosine | 2018 |
Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Frontotemporal Dementia; Gene Expression; HEK293 Cells; Heterogeneous-Nuclear Ribonucleoprotein Group F-H; Humans; Mutagenesis, Site-Directed; Mutation; Photoreceptor Cells, Invertebrate; Protein Domains; Protein Folding; Recombinant Fusion Proteins; Retinal Degeneration; Tyrosine | 2018 |
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.
Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; Cations; DNA Methylation; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Humans; Microscopy, Atomic Force; Microscopy, Fluorescence; Molecular Chaperones; Protein Binding; Protein Domains; Protein Processing, Post-Translational; Protein Structure, Secondary; RNA-Binding Protein FUS; Tyrosine; Xenopus laevis | 2018 |
Molecular mechanisms involved in the protective effect of pituitary adenylate cyclase-activating polypeptide in an in vitro model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cell Survival; Culture Media, Serum-Free; Cyclic AMP-Dependent Protein Kinases; ErbB Receptors; Matrix Metalloproteinase 2; Mice; Mitogen-Activated Protein Kinases; Motor Neurons; Mutation; Nerve Degeneration; Phosphorylation; Pituitary Adenylate Cyclase-Activating Polypeptide; Signal Transduction; Superoxide Dismutase-1; Tyrosine | 2019 |
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Axons; Cell Death; Diaphragm; Embryo Loss; Embryo, Mammalian; Exons; Female; Fibroblasts; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Motor Neurons; Muscular Atrophy, Spinal; Neuromuscular Diseases; Oxidative Stress; Respiration; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Transfer, Tyr; Spinal Nerves; Transcription Factors; Tumor Suppressor Protein p53; Tyrosine | 2013 |
Nitration of Hsp90 induces cell death.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Disease Models, Animal; fas Receptor; HSP90 Heat-Shock Proteins; Humans; Motor Neurons; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Spinal Cord Injuries; Tyrosine | 2013 |
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Axons; Dietary Supplements; Disease Models, Animal; Disease Progression; Eicosapentaenoic Acid; Female; Humans; Lipid Metabolism; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Motor Neurons; Mutant Proteins; Neuroglia; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Survival Analysis; Tyrosine; Vacuoles | 2013 |
NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axonal Transport; Blotting, Western; Body Weight; Brain; Contrast Media; Disease Progression; Female; Magnetic Resonance Imaging; Male; Manganese; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroprotective Agents; Oligopeptides; Phosphorylation; Psychomotor Performance; Spinal Cord; tau Proteins; Tubulin; Tyrosine; Ventral Tegmental Area | 2013 |
Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Brain; Female; Gene Expression Regulation, Enzymologic; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Neurons; Neurotoxins; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; RNA, Messenger; src-Family Kinases; tau Proteins; Time Factors; Tyrosine | 2014 |
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Survival; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glutamate Plasma Membrane Transport Proteins; Humans; Male; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Tyrosine | 2014 |
Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; beta Karyopherins; Frontotemporal Lobar Degeneration; HeLa Cells; Humans; Molecular Sequence Data; Phosphorylation; RNA-Binding Protein FUS; Tyrosine | 2015 |
Anti-MuSK Antibody-positive Myasthenia Gravis Mimicking Amyotrophic Lateral Sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Autoantibodies; Biomarkers; Deglutition Disorders; Disease Progression; Drug Administration Schedule; Female; Glucocorticoids; Humans; Middle Aged; Myasthenia Gravis; Prednisolone; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Treatment Outcome; Tyrosine | 2015 |
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cytoplasm; Glutamic Acid; Inclusion Bodies; Kinesins; Mice; Microtubules; Mutation; NIH 3T3 Cells; Protein Transport; RNA; RNA-Binding Protein FUS; RNA-Binding Proteins; RNA, Messenger; Sarcoma; Tubulin; Tubulin Modulators; Tyrosine | 2017 |
Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Middle Aged; Monocytes; Proteomics; Rats; Tyrosine | 2009 |
Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cytochromes c; Disease Models, Animal; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Mutation; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Superoxide Dismutase; Tyrosine; Ubiquitin | 2009 |
Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Catalytic Domain; Central Nervous System; Disease Models, Animal; Disease Progression; Facial Nerve; Gene Expression Regulation; Hepatocyte Growth Factor; Humans; Mice; Mice, Transgenic; Motor Neurons; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-met; Rhombencephalon; Serine; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.
Topics: Aconitate Hydratase; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Detergents; Disease Models, Animal; Disease Progression; Electrophoresis, Gel, Two-Dimensional; Humans; Immunohistochemistry; Mice; NG-Nitroarginine Methyl Ester; Protein Structure, Quaternary; Proteins; Proteomics; Reproducibility of Results; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spinal Cord; Stress, Physiological; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
A novel SOD1 mutation in a young amyotrophic lateral sclerosis patient with a very slowly progressive clinical course.
Topics: Adult; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Disease Progression; Electromyography; Humans; Leg; Male; Muscle Weakness; Muscle, Skeletal; Mutation; Peripheral Nerves; Phenotype; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Tyrosine | 2010 |
Neurofilament heavy subunit in cerebrospinal fluid: a biomarker of amyotrophic lateral sclerosis?
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Female; Humans; Male; Middle Aged; Neurofilament Proteins; Neurons; Protein Subunits; Spinal Cord; Tyrosine | 2011 |
D11Y SOD1 mutation and benign ALS: a consistent genotype-phenotype correlation.
Topics: Aged; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Genetic Association Studies; Humans; Middle Aged; Mutation; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2011 |
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium-Binding Proteins; Cerebral Cortex; Deoxyguanosine; Dinoprostone; Disease Models, Animal; Encephalitis; Free Radical Scavengers; Free Radicals; Gene Expression Regulation; Humans; Ibuprofen; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Motor Neurons; Oxidative Stress; Riluzole; Spinal Cord; Sulfasalazine; Superoxide Dismutase; Tyrosine | 2012 |
Impact of treadmill running and sex on hippocampal neurogenesis in the mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Animals; Bromodeoxyuridine; Cell Proliferation; Cell Survival; Dentate Gyrus; Deoxyguanosine; Disease Models, Animal; Exercise Test; Female; Gene Expression Regulation; Hippocampus; Intercellular Signaling Peptides and Proteins; Male; Mice; Neurogenesis; Neurons; Oxidative Stress; Phenotype; Physical Conditioning, Animal; RNA, Messenger; Sex Characteristics; Tyrosine | 2012 |
Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Topics: Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; beta Karyopherins; Crystallization; Escherichia coli; Humans; Models, Molecular; Nuclear Localization Signals; Proline; Protein Conformation; RNA-Binding Protein FUS; Thermodynamics; Tyrosine | 2012 |
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Arginine; Cell Nucleus; Frontotemporal Lobar Degeneration; Gene Silencing; HeLa Cells; Humans; Karyopherins; Methylation; Molecular Sequence Data; Nuclear Localization Signals; Proline; Protein Binding; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA-Binding Protein FUS; Signal Transduction; Tyrosine | 2012 |
Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biomarkers; Female; Humans; Male; Middle Aged; Tyrosine | 2004 |
Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Cell Count; Disease Models, Animal; Disease Progression; Gliosis; Lumbosacral Region; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pioglitazone; PPAR gamma; Psychomotor Performance; Spinal Cord; Superoxide Dismutase; Survival Rate; Thiazolidinediones; Tyrosine; Weight Loss | 2005 |
Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Apoptosis; Astrocytes; Caspase 3; Cell Count; Cells, Cultured; Coculture Techniques; Embryo, Mammalian; Fibroblast Growth Factor 1; Fluorescent Antibody Technique; Free Radical Scavengers; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Metalloporphyrins; Mice; Mice, Transgenic; Motor Neurons; Nerve Growth Factor; Protein-Tyrosine Kinases; Pyrimidines; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Nerve Growth Factor; RNA, Messenger; Spinal Cord; Superoxide Dismutase; Tyrosine; Urea | 2005 |
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amyotrophic Lateral Sclerosis; Animals; Brain; Corpus Striatum; Dopamine; Drug Evaluation, Preclinical; Enzyme Induction; Humans; Huntington Disease; Hypochlorous Acid; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2005 |
Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Fas Ligand Protein; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Motor Neurons; Nitric Oxide Synthase Type I; Probability; Spinal Cord; Superoxide Dismutase; Survival Analysis; Tyrosine | 2006 |
Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Disease Models, Animal; Disease Progression; Gliosis; Mice; Mice, Transgenic; Psychomotor Performance; Pyruvic Acid; Spinal Cord; Superoxide Dismutase; Survival Analysis; Tyrosine | 2007 |
Identification of a novel D109Y mutation in Cu/Zn superoxide dismutase (sod1) gene associated with amyotrophic lateral sclerosis.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Base Sequence; Catalytic Domain; Central Nervous System; Codon; Disease Progression; DNA Mutational Analysis; Fatal Outcome; Female; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Mutation, Missense; Superoxide Dismutase; Tyrosine | 2007 |
Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Axons; Humans; Immunohistochemistry; Motor Neurons; Phosphorylation; Protein-Tyrosine Kinases; Spinal Cord; Superoxide Dismutase; Superoxides; Tyrosine | 1995 |
Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study.
Topics: Amyotrophic Lateral Sclerosis; Citrulline; Cyclic GMP; Cytoplasm; Humans; Immunohistochemistry; Motor Neurons; Neurofilament Proteins; Nitrates; Nitric Oxide; Nitrogen; Oxidation-Reduction; Superoxide Dismutase; Tyrosine | 1996 |
Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND.
Topics: Aged; Amyotrophic Lateral Sclerosis; Axons; Calmodulin; Citrulline; Cyclic GMP; Female; Humans; Inclusion Bodies; Male; Microscopy, Electron; Middle Aged; Motor Neurons; Neurofilament Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Compounds; Superoxide Dismutase; Tyrosine; Ubiquitins | 1996 |
Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Brain; Endothelium, Vascular; Enzyme Induction; Humans; Immunohistochemistry; Motor Neurons; Nitric Oxide Synthase; Reference Values; Spinal Cord; Staining and Labeling; Superoxide Dismutase; Tyrosine | 1997 |
Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide di
Topics: Amyotrophic Lateral Sclerosis; Animals; Free Radicals; Humans; Mice; Mice, Transgenic; Mutation; Protein Binding; Superoxide Dismutase; Tyrosine | 1997 |
Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite.
Topics: Amyotrophic Lateral Sclerosis; Animals; Binding Sites; Catalysis; Cloning, Molecular; Humans; Kinetics; Liver; Metallothionein; Models, Structural; Mutagenesis, Site-Directed; Mutation; Nitrates; Protein Conformation; Rabbits; Recombinant Proteins; Superoxide Dismutase; Tyrosine; Zinc | 1997 |
Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Antibodies, Monoclonal; Family Health; Female; Humans; Male; Middle Aged; Motor Neurons; Mutation; Nissl Bodies; Nitrophenols; Oxidative Stress; Phenylacetates; Spinal Cord; Superoxide Dismutase; Tyrosine | 1997 |
Nitration of the low molecular weight neurofilament is equivalent in sporadic amyotrophic lateral sclerosis and control cervical spinal cord.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Blotting, Western; Humans; Isoelectric Focusing; Middle Aged; Neurofilament Proteins; Nitrates; Precipitin Tests; Spinal Cord; Tyrosine | 1998 |
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Creatine; Disease Models, Animal; Glycine; Humans; Mice; Mice, Transgenic; Motor Activity; Muscle, Skeletal; Neurons; Neuroprotective Agents; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine; Tyrosine 3-Monooxygenase | 1999 |
Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Tyrosine | 1999 |
Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Brain; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Mutation; Neuroglia; Neurons; Spinal Cord; Superoxide Dismutase; Tyrosine | 2000 |
Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Base Sequence; DNA Primers; Humans; Phosphorylation; Receptor, trkB; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Spinal Cord; Tyrosine | 2000 |
iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Anterior Horn Cells; Astrocytes; Axons; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Lumbosacral Region; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pyramidal Tracts; Tyrosine | 2000 |
Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis.
Topics: Aldehydes; Amyotrophic Lateral Sclerosis; Antioxidants; Cell Division; Cell Line; Cell Survival; Down Syndrome; Gene Expression; Glutathione; Glutathione Disulfide; Guanine; Humans; Ketones; Lipid Peroxidation; Mutation; Neuroblastoma; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Teratocarcinoma; Transfection; Tyrosine | 2001 |
Nitrotyrosination contributes minimally to toxicity of mutant SOD1 associated with ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cell Survival; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Humans; Mice; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Superoxide Dismutase; Tyrosine | 2001 |
Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords of transgenic mice with a G93A mutant SOD1 gene.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antibodies; Blotting, Western; Female; Humans; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2001 |
Selective and nonselective susceptibility of muscle fiber types. A new approach to human neuromuscular diseases.
Topics: Adolescent; Amyotrophic Lateral Sclerosis; Animals; Biopsy; Cats; Dermatomyositis; Esterases; Female; Glucosyltransferases; Glycogen; Guinea Pigs; Histocytochemistry; Humans; Male; Muscular Atrophy; Muscular Diseases; Muscular Dystrophies; Myofibrils; Nervous System Diseases; Oxidoreductases; Paralysis; Rabbits; Schwann Cells; Staining and Labeling; Transferases; Tyrosine | 1970 |