tyrosine and Alkaptonuria

tyrosine has been researched along with Alkaptonuria in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (41.79)	18.7374
1990's	5 (7.46)	18.2507
2000's	5 (7.46)	29.6817
2010's	15 (22.39)	24.3611
2020's	14 (20.90)	2.80

Authors

Authors	Studies
Arslan Gulten, Z; Arslan, N; Aydogan, A; Bahceci, H; Eroglu Erkmen, S; Karalar Pekuz, OK; Ozturk, T; Teke Kisa, P; Uysal, S; Yuce Inel, T	1
Berdeli, A; Bozaci, AE; Canda, E; Coker, M; Guvenc, MS; Habif, S; Uçar, SK; Yazici, H	1
Batalov, A; Batalov, Z; Karalilova, R; Kostova, T	1
Arnoux, JB; Bou-Gharios, G; Davison, AS; Gallagher, JA; Hughes, AT; Imrich, R; M, K; Milan, AM; Norman, BP; Olsson, B; Ranganath, LR; Rudebeck, M	1
Havranova, A; Imrich, R; Lukacova, O; Penesova, A; Radikova, Z; Ranganath, L; Sedlakova, J; Vlcek, M; Zanova, E; Zatkova, A	1
Davison, AS; Norman, BP	1
Bou-Gharios, G; Gallagher, JA; Hughes, AT; Hughes, JH; Jarvis, JC; Judd, S; Milan, AM; Ranganath, LR; Sutherland, H; Wilson, PJM	1
Davison, AS; Gallagher, JA; Hughes, AT; Milan, AM; Ranganath, LR; Sireau, N	1
Arnoux, JB; Braconi, D; Bygott, H; Davison, AS; Fitzgerald, R; Gallagher, JA; Genovese, F; Glasova, H; Hughes, AT; Hughes, JH; Imrich, R; Jarvis, JC; Khedr, M; Laan, D; Le Quan Sang, KH; Luangrath, E; Mankowitz, L; Milan, AM; Norman, BP; Olsson, B; Psarelli, EE; Ranganath, LR; Rhodes, NP; Rudebeck, M; Santucci, A; Shweihdi, E; Sireau, N; Stančík, R; van Kan, C; Zatkova, A	1
Cooper, MS; Davison, AS; Deutz, NEP; Fitzgerald, R; Gallagher, JA; Ghane, P; Hughes, AT; Jarvis, JC; Khedr, M; Markinson, L; Milan, AM; Norman, BP; Psarelli, EE; Ranganath, LR; Sutherland, H	1
Auh, S; Avadhanula, S; Burman, KD; Ciccone, C; Filie, AC; Hannah-Shmouni, F; Introne, WJ; Klubo-Gwiezdzinska, J; Regier, D; Soldin, SJ; Stolze, B	1
Hakamata, H; Kishi, T; Kotani, A; Umemura, T	1
Bhatt, A; Dhyani, R; Hussain, A; Jain, S; Navani, NK; Shankar, K	1
Heiner-Fokkema, MR; van Spronsen, FJ; Wolffenbuttel, BHR	1
Elmalah, I; Hakim, R; Krausz, J; Rozen, N; Spiegel, R; Zatkova, A	1
Davison, AS; Devine, J; Gallagher, JA; Harrold, JA; Hughes, AT; Hughes, G; J C G, H; Khedr, M; Milan, AM; Norman, BP; Ranganath, LR; Usher, J	1
Adam, D	1
Curtis, SL; Gallagher, JA; Milan, AM; Norman, BP; Olsson, B; Ranganath, LR; Roberts, NB	1
Alqahtani, A; Blum, A; Feillet, F; Guéant, JL; Henn-Ménétré, S; Jeannesson, E; Merten, M; Renard, E; Sloboda, N; Wiedemann, A	1
Cox, TF; Davison, AS; Gallagher, JA; Hughes, AT; Khedr, M; Milan, AM; Psarelli, EE; Ranganath, LR; Rhodes, NP; Rovensky, J	1
Goldstein, J; Lok, ZS; Smith, JA	1
Christensen, P; Davison, AS; Dutton, JJ; Gallagher, JA; Hughes, AT; Milan, AM; Ranganath, LR; Ross, G	2
Ayoob, H; Braconi, D; Briggs, MC; Bygott, H; Christensen, P; Cox, TF; Cronlund, A; Dutton, JJ; Fitzgerald, R; Gallagher, JA; Genovese, F; Hall, AK; Hughes, AT; Imrich, R; Jarvis, JC; Junestrand, C; Kullenberg, T; Laan, D; Le Quan Sang, KH; McCaffrey, J; Milan, AM; Nemethova, M; Olsson, B; Psarelli, EE; Ranganath, LR; Ross, G; Rovensky, J; Rudebeck, M; Santucci, A; Sireau, N; Svensson, L; Szamosi, J; Timmis, OG; van Kan, C; Zatkova, A	1
Barshop, BA; Gangoiti, JA; Gertsman, I; Nyhan, WL	1
Arnoux, JB; Brassier, A; de Lonlay, P; Dubois, S; Grisel, C; Job-Deslandre, C; Le Quan Sang, KH; Ranganath, L; Servais, A; Sireau, N; Wippf, J	1
Curtis, S; Davison, AS; Devine, J; Gallagher, JA; Hughes, AT; Khedr, M; Milan, AM; Ranganath, LR; Usher, J	1
Bernardini, I; Bryant, J; Gahl, WA; Introne, WJ; Kayser, MA; Moylan, E; O'Brien, KE; Perry, MB; Reynolds, JC; Sachdev, V; Suwannarat, P; Troendle, J; Tsilou, E	1
Chen, MY; Gahl, WA; Hannoush, H; Introne, WJ; Kayser, MA; Lee, SJ; O'Brien, K; Sachdev, V; Suwannarat, P	1
Anderson, PD; Anikster, Y; Bernardini, I; Fitzpatrick, DL; Gahl, WA; Gerber, LH; Huizing, M; Introne, WJ; Murphey, MD; Perry, MB; Phornphutkul, C	1
KNOX, WE; LIN, EC	1
LA DU, BN; LASTER, L; SEEGMILLER, JE; ZANNONI, VG	1
SCHULTZE-JENA, BS	1
CLAYTON, BE	1
BONDURANT, RE; HENRY, JB	1
FINCKE, ML	1
Bernardini, I; Gahl, WA; Gerber, LH; Kaiser-Kupfer, MI; O'Brien, K; Perry, MB; Rubin, BI; Sebring, N; Suwannarat, P; Tsilou, E	1
Held, PK	1
Kopecký, S; Trnavská, Z; Trnavský, K	1
Lee, EB	1
Jyothy, A; Reddy, PP	1
Kotwal, MR; Rinchhen, CZ	1
Deutsch, JC; Santhosh-Kumar, CR	1
Scazzocchio, C	1
Dom, K; Pittevils, T	1
Takita, H	1
Anikster, Y; Gahl, WA; Nyhan, WL	1
Peñalva, MA	1
Cercek, M; Kozelj, M; Prokselj, K	1
Bethel, RA; Faraj, BA; Fulenwider, JT; Nordlinger, BM; Rudman, D	1
Wirtschafter, JD	1
Mohr, W; Richter, R	1
Angsusingha, K; Punnakanta, L; Tuchinda, C	1
Irons, M; Levy, HL	1
Felgenhauer, WR; Roth, M	1
Friis, J	1
Kroll, S; Toussaint, W; Zebisch, P	2
Simon, C	1
Balda, BR; Lukacs, I	1
Hill, A; Hoag, GN; Zaleski, WA	1
Adolphsen, P; Lenz, H; Siegenthaler, W; Zimmermann, KG	1
Lustberg, TJ; Schulman, JD; Seegmiller, JE	1
Hakuno, T; Ito, J; Nishimori, I	1
Karoum, F; Ruthven, CR; Sandler, M	1
Borud, O; Gjessing, LR	1
Blivaiss, BB; Kutuzov, H; Rosenberg, EF; Stoner, R	1

Reviews

14 review(s) available for tyrosine and Alkaptonuria

Article	Year
Efficacy of Phenylalanine- and Tyrosine-Restricted Diet in Alkaptonuria Patients on Nitisinone Treatment: Case Series and Review of Literature. Annals of nutrition & metabolism, 2022, Volume: 78, Issue:1 Topics: Adult; Alkaptonuria; Cyclohexanones; Diet; Dietary Proteins; Female; Humans; Male; Middle Aged; Nitrobenzoates; Phenylalanine; Tyrosine	2022
Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review. Rheumatology international, 2022, Volume: 42, Issue:12 Topics: Aged; Alkaptonuria; Ascorbic Acid; Cartilage Diseases; Dioxygenases; Homogentisic Acid; Humans; Joint Diseases; Ochronosis; Osteoarthritis; Quality of Life; Spondylarthropathies; Tyrosine	2022
Alkaptonuria - Past, present and future. Advances in clinical chemistry, 2023, Volume: 114 Topics: Alkaptonuria; Animals; Homogentisic Acid; Humans; Mice; Quality of Life; Tyrosine; Tyrosinemias	2023
Alkaptonuria - Many questions answered, further challenges beckon. Annals of clinical biochemistry, 2020, Volume: 57, Issue:2 Topics: Alkaptonuria; Animals; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Homogentisic Acid; Humans; Mice; Nitrobenzoates; Tyrosine	2020
Alkaptonuria-associated aortic stenosis. Journal of cardiac surgery, 2013, Volume: 28, Issue:4 Topics: Aged; Alkaptonuria; Aortic Valve; Aortic Valve Stenosis; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Homogentisic Acid; Humans; Male; Middle Aged; Myocardium; Treatment Outcome; Tyrosine	2013
Old treatments for new insights and strategies: proposed management in adults and children with alkaptonuria. Journal of inherited metabolic disease, 2015, Volume: 38, Issue:5 Topics: Adult; Age Factors; Alkaptonuria; Antioxidants; Child; Cyclohexanones; Humans; Nitrobenzoates; Ochronosis; Phenylalanine; Tyrosine	2015
Metabolic diseases and the skin. Pediatric clinics of North America, 1983, Volume: 30, Issue:4 Topics: Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Argininosuccinic Acid; Biotin; Child; Child, Preschool; Hartnup Disease; Homocystinuria; Humans; Infant; Infant, Newborn; Phenylketonurias; Skin Diseases; Tyrosine; Tyrosine Transaminase	1983
Ochronotic arthropathy: the black hip. Case report and review of the literature. Acta orthopaedica Belgica, 1997, Volume: 63, Issue:2 Topics: Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Cartilage, Articular; Follow-Up Studies; Hip Joint; Hip Prosthesis; Humans; Male; Middle Aged; Ochronosis; Osteoarthritis; Phenylalanine; Tyrosine	1997
[Alkaptonuria (homogentisic aciduria)]. Ryoikibetsu shokogun shirizu, 1998, Issue:18 Pt 1 Topics: Alkaptonuria; Arthritis; Diagnosis, Differential; Dioxygenases; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Ochronosis; Oxygenases; Phenylalanine; Tyrosine	1998
A fungal perspective on human inborn errors of metabolism: alkaptonuria and beyond. Fungal genetics and biology : FG & B, 2001, Volume: 34, Issue:1 Topics: Alkaptonuria; Animals; Aspergillus nidulans; Genes, Fungal; Humans; Metabolism, Inborn Errors; Models, Chemical; Mutation; Phenylalanine; Tyrosine	2001
The eye in alkaptonuria. Birth defects original article series, 1976, Volume: 12, Issue:3 Topics: Alkaptonuria; Chemical Phenomena; Chemistry; Connective Tissue; Diagnosis, Differential; Diagnostic Errors; Eye Diseases; Eye Neoplasms; Female; Humans; Joint Diseases; Male; Melanoma; Ochronosis; Oxidation-Reduction; Pigmentation; Tyrosine	1976
Metabolic syndromes with dermatologic manifestations. Clinical reviews in allergy, 1986, Volume: 4, Issue:1 Topics: Albinism; Alkaptonuria; Amidohydrolases; Amino Acid Metabolism, Inborn Errors; Amino Acids; Biotinidase; Carbohydrate Metabolism; Eczema; Hartnup Disease; Homocystinuria; Humans; Keratosis; Menkes Kinky Hair Syndrome; Metabolic Diseases; Phenylketonurias; Porphyrias; Skin Diseases; Steryl-Sulfatase; Sulfatases; Tyrosine; Urea	1986
[Ochronotic arthropathy]. Ugeskrift for laeger, 1973, Dec-03, Volume: 135, Issue:49 Topics: Alkaptonuria; Ascorbic Acid; Cartilage, Articular; Homogentisic Acid; Humans; Joint Diseases; Ochronosis; Oxygenases; Tyrosine	1973
[Molecular biologic aspects in dermatology demonstrated by some hereditary enzyme defects]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1968, Dec-01, Volume: 43, Issue:23 Topics: Albinism; Alkaptonuria; Anemia, Sickle Cell; Chromosomes; Hartnup Disease; Humans; Maple Syrup Urine Disease; Metabolism, Inborn Errors; Models, Chemical; Molecular Biology; Phenylalanine; Phenylketonurias; Porphyrias; Skin Diseases; Tyrosine	1968

Trials

3 trial(s) available for tyrosine and Alkaptonuria

Article	Year
Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria. Scientific reports, 2019, 07-11, Volume: 9, Issue:1 Topics: Adult; Alkaptonuria; Cyclohexanones; Female; Homogentisic Acid; Humans; Male; Middle Aged; Nitrobenzoates; Phenylalanine; Pigments, Biological; Tandem Mass Spectrometry; Tyrosine	2019
Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid Annals of the rheumatic diseases, 2016, Volume: 75, Issue:2 Topics: Adult; Alkaptonuria; Cyclohexanones; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Homogentisic Acid; Humans; Male; Middle Aged; Nitrobenzoates; Research Design; Tyrosine	2016
A 3-year randomized therapeutic trial of nitisinone in alkaptonuria. Molecular genetics and metabolism, 2011, Volume: 103, Issue:4 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Adult; Alkaptonuria; Cyclohexanones; Homogentisic Acid; Humans; Middle Aged; Nitrobenzoates; Prospective Studies; Tyrosine	2011

Other Studies

50 other study(ies) available for tyrosine and Alkaptonuria

Article	Year
Long-term follow-up of alkaptonuria patients: single center experience. Journal of pediatric endocrinology & metabolism : JPEM, 2022, Jul-26, Volume: 35, Issue:7 Topics: Adult; Alkaptonuria; Child; Female; Follow-Up Studies; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Male; Retrospective Studies; Tyrosine	2022
Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria. Scientific reports, 2022, 09-27, Volume: 12, Issue:1 Topics: Alkaptonuria; Brain Diseases, Metabolic, Inborn; Cyclohexanones; Homogentisic Acid; Humans; Nitrobenzoates; Phenylalanine; Phenylpropionates; Tyrosine; Tyrosinemias	2022
Nutritional interventions for patients with alkaptonuria: A minireview. Endocrine regulations, 2023, Jan-01, Volume: 57, Issue:1 Topics: Alkaptonuria; Homogentisic Acid; Humans; Ochronosis; Tyrosine; Tyrosinemias	2023
Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria. Journal of inherited metabolic disease, 2020, Volume: 43, Issue:2 Topics: Alkaptonuria; Animals; Cyclohexanones; Diet, Protein-Restricted; Female; Humans; Male; Mice; Nitrobenzoates; Phenylalanine; Tyrosine; Tyrosinemias	2020
Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria. Journal of inherited metabolic disease, 2020, Volume: 43, Issue:4 Topics: Adult; Alkaptonuria; Case-Control Studies; Creatinine; Female; Glomerular Filtration Rate; Homogentisic Acid; Humans; Kidney; Linear Models; Male; Middle Aged; Ochronosis; Phenylalanine; Sex Factors; Tyrosine	2020
Nitisinone causes acquired tyrosinosis in alkaptonuria. Journal of inherited metabolic disease, 2020, Volume: 43, Issue:5 Topics: Adult; Aged; Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Animals; Cyclohexanones; Female; Humans; Male; Mice; Mice, Inbred BALB C; Middle Aged; Nitrobenzoates; Phenylalanine; Tyrosine; Young Adult	2020
Assessment of Thyroid Function in Patients With Alkaptonuria. JAMA network open, 2020, 03-02, Volume: 3, Issue:3 Topics: Adult; Alkaptonuria; Autoantibodies; Autoantigens; Cohort Studies; Female; Homogentisic Acid; Humans; Hyperthyroidism; Hypothyroidism; Iodide Peroxidase; Iron-Binding Proteins; Logistic Models; Male; Middle Aged; Prevalence; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Tyrosine	2020
HPLC with electrochemical detection for determining homogentisic acid and its application to urine from rats fed tyrosine-enriched food. Journal of pharmaceutical and biomedical analysis, 2020, Jul-15, Volume: 186 Topics: Alkaptonuria; Animal Feed; Animals; Chromatography, High Pressure Liquid; Electrochemical Techniques; Food, Fortified; Homogentisic Acid; Limit of Detection; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Tyrosine	2020
Homogentisic Acid-Based Whole-Cell Biosensor for Detection of Alkaptonuria Disease. Analytical chemistry, 2021, 03-16, Volume: 93, Issue:10 Topics: Alkaptonuria; Biosensing Techniques; Chromatography, High Pressure Liquid; Homogentisic Acid; Humans; Tyrosine	2021
Preventive use of nitisinone in alkaptonuria. Orphanet journal of rare diseases, 2021, 08-03, Volume: 16, Issue:1 Topics: Alkaptonuria; Cyclohexanones; Humans; Nitrobenzoates; Tyrosine	2021
Degenerative Osteoarthritis with Multiple Joint Arthroplasties Due to Alkaptonuria, a Rare Inborn Error of Tyrosine Metabolism. The Israel Medical Association journal : IMAJ, 2018, Volume: 20, Issue:4 Topics: Aged; Alkaptonuria; Arthroplasty; Humans; Male; Osteoarthritis; Tyrosine	2018
Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone. Molecular genetics and metabolism, 2018, Volume: 125, Issue:1-2 Topics: Adolescent; Adult; Aged; Alkaptonuria; Cyclohexanones; Depression; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Nitrobenzoates; Tyrosine; Young Adult	2018
A father's fight to help his sons - and fix clinical trials. Nature, 2019, Volume: 565, Issue:7738 Topics: Adolescent; Alkaptonuria; Animals; Autopsy; Child; Clinical Trials as Topic; Compassionate Use Trials; Cyclohexanones; Disease Models, Animal; Disease Progression; Drug Approval; Endpoint Determination; Female; Homogentisic Acid; Humans; Infant; Male; Mice; National Health Programs; National Institutes of Health (U.S.); Nitrobenzoates; Observational Studies as Topic; Off-Label Use; Orphan Drug Production; Rare Diseases; Rats; Sample Size; Tyrosine; Tyrosinemias; United States; United States Food and Drug Administration	2019
Interference of hydroxyphenylpyruvic acid, hydroxyphenyllactic acid and tyrosine on routine serum and urine clinical chemistry assays; implications for biochemical monitoring of patients with alkaptonuria treated with nitisinone. Clinical biochemistry, 2019, Volume: 71 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Cyclohexanones; Enzyme Inhibitors; Humans; Nitrobenzoates; Phenylpropionates; Phenylpyruvic Acids; Tyrosine	2019
Efficacy of low dose nitisinone in the management of alkaptonuria. Molecular genetics and metabolism, 2019, Volume: 127, Issue:3 Topics: Adult; Alkaptonuria; Child, Preschool; Cyclohexanones; Diet; Dose-Response Relationship, Drug; Female; Humans; Magnetic Resonance Spectroscopy; Male; Nitrobenzoates; Tyrosine; Young Adult	2019
Urine homogentisic acid and tyrosine: simultaneous analysis by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jul-15, Volume: 963 Topics: Alkaptonuria; Chromatography, Liquid; Homogentisic Acid; Humans; Limit of Detection; Tandem Mass Spectrometry; Tyrosine	2014
Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry. Annals of clinical biochemistry, 2015, Volume: 52, Issue:Pt 5 Topics: Alkaptonuria; Biomarkers; Chromatography, Liquid; Cyclohexanones; Homogentisic Acid; Humans; Nitrobenzoates; Tandem Mass Spectrometry; Tyrosine	2015
Perturbations of tyrosine metabolism promote the indolepyruvate pathway via tryptophan in host and microbiome. Molecular genetics and metabolism, 2015, Volume: 114, Issue:3 Topics: Aldehydes; Alkaptonuria; Cell Line, Tumor; Cyclohexanones; Gastrointestinal Microbiome; Humans; Indoles; Mass Spectrometry; Metabolomics; Nitrobenzoates; Phenylpyruvic Acids; Symbiosis; Tryptophan; Tyrosine; Tyrosinemias	2015
The effect of nitisinone on homogentisic acid and tyrosine: a two-year survey of patients attending the National Alkaptonuria Centre, Liverpool. Annals of clinical biochemistry, 2017, Volume: 54, Issue:3 Topics: Adult; Aged; Alkaptonuria; Chromatography, Liquid; Cyclohexanones; Drug Administration Schedule; Enzyme Inhibitors; Female; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Longitudinal Studies; Male; Middle Aged; Monitoring, Physiologic; Nitrobenzoates; Tandem Mass Spectrometry; Tyrosine; United Kingdom	2017
Aortic stenosis and vascular calcifications in alkaptonuria. Molecular genetics and metabolism, 2012, Volume: 105, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alkaptonuria; Aortic Valve Stenosis; Cardiovascular System; Echocardiography; Female; Homogentisic Acid; Humans; Male; Middle Aged; Pigments, Biological; Tyrosine; Vascular Calcification; Young Adult	2012
Natural history of alkaptonuria. The New England journal of medicine, 2002, Dec-26, Volume: 347, Issue:26 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Alkaptonuria; Child; Child, Preschool; Connective Tissue Diseases; Cyclohexanones; Dioxygenases; Disease Progression; DNA Mutational Analysis; Enzyme Inhibitors; Female; Heart Valve Diseases; Homogentisate 1,2-Dioxygenase; Humans; Joint Diseases; Kidney Calculi; Life Tables; Linear Models; Longitudinal Studies; Male; Middle Aged; Mutation; Nitrobenzoates; Oxygenases; Severity of Illness Index; Tyrosine	2002
Role of enzymatic adaptation in production of experimental alkaptonuria. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1957, Volume: 96, Issue:2 Topics: Acclimatization; Adaptation, Physiological; Alkaptonuria; Liver; Oxidoreductases; Transaminases; Tyrosine	1957
The nature of the defect in tyrosine metabolism in alcaptonuria. The Journal of biological chemistry, 1958, Volume: 230, Issue:1 Topics: Alkaptonuria; Humans; Liver; Oxidoreductases; Tyrosine	1958
[Hereditary enzyme defects of amino acid metabolism]. Ergebnisse der inneren Medizin und Kinderheilkunde, 1962, Volume: 18 Topics: Albinism; Alkaptonuria; Amino Acids; Humans; Maple Syrup Urine Disease; Metabolic Diseases; Phenylketonurias; Proteins; Tryptophan; Tyrosine	1962
Symposium on metabolic diseases of the eye, Biochemical remarks on amino acid metabolism. Proceedings of the Royal Society of Medicine, 1963, Volume: 56 Topics: Alkaptonuria; Amino Acids; Humans; Metabolic Diseases; Phenylalanine; Proteins; Tyrosine	1963
PATHOGENESIS OF OCHRONOSIS IN EXPERIMENTAL ALKAPTONURIA OF THE WHITE RAT. Laboratory investigation; a journal of technical methods and pathology, 1965, Volume: 14 Topics: Alkaptonuria; Aorta; Cartilage; Cartilage, Articular; Femur Head; Heart; Hip Joint; Humans; Kidney; Knee Joint; Liver; Male; Ochronosis; Organ Size; Pathology; Phenylacetates; Pigmentation; Prostate; Rats; Research; Spleen; Thyroid Gland; Trachea; Tyrosine; Urinary Bladder; Urine	1965
INBORN ERRORS OF METABOLISM. Journal of the American Dietetic Association, 1965, Volume: 46 Topics: Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Carbohydrate Metabolism; Carbohydrate Metabolism, Inborn Errors; Classification; Clinical Laboratory Techniques; Galactosemias; Genetics, Medical; Humans; Intellectual Disability; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Maple Syrup Urine Disease; Mass Screening; Phenylketonurias; Tyrosine	1965
Use of nitisinone in patients with alkaptonuria. Metabolism: clinical and experimental, 2005, Volume: 54, Issue:6 Topics: Adult; Aged; Alkaptonuria; Cyclohexanones; Dietary Proteins; Female; Homogentisic Acid; Humans; Male; Middle Aged; Nitrobenzoates; Tyrosine	2005
Disorders of tyrosine catabolism. Molecular genetics and metabolism, 2006, Volume: 88, Issue:2 Topics: Alkaptonuria; Animals; cis-trans-Isomerases; Humans; Tyrosine; Tyrosinemias	2006
[Biological formation of collagen proteins in connective tissue]. Casopis lekaru ceskych, 1967, Volume: 106, Issue:39 Topics: Alkaptonuria; Animals; Biochemical Phenomena; Biochemistry; Collagen; Connective Tissue; Humans; Phenylacetates; Protein Biosynthesis; Quinones; Rats; Tyrosine	1967
Screening for aminoacid disorders in mental retardation. Indian pediatrics, 1984, Volume: 21, Issue:5 Topics: Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Child, Preschool; Female; Humans; Infant; Intellectual Disability; Kynurenine; Male; Renal Aminoacidurias; Tyrosine	1984
Alkaptonuria. Journal of the Indian Medical Association, 1983, Jan-01, Volume: 80, Issue:1 Topics: Alkaptonuria; Dietary Proteins; Humans; Male; Middle Aged; Phenylalanine; Tyrosine	1983
Quantitation of homogentisic acid in normal human plasma. Journal of chromatography. B, Biomedical applications, 1996, Feb-23, Volume: 677, Issue:1 Topics: Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Gas Chromatography-Mass Spectrometry; Heterozygote; Homogentisic Acid; Humans; Radioisotope Dilution Technique; Tyrosine	1996
Alkaptonuria: from humans to moulds and back. Trends in genetics : TIG, 1997, Volume: 13, Issue:4 Topics: Alkaptonuria; Aspergillus nidulans; Dioxygenases; History, 20th Century; Homogentisate 1,2-Dioxygenase; Humans; Oxygenases; Phenylalanine; Tyrosine	1997
NTBC and alkaptonuria. American journal of human genetics, 1998, Volume: 63, Issue:3 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Cyclohexanones; Enzyme Inhibitors; Humans; Nitrobenzoates; Tyrosine	1998
Aortic valve stenosis in alkaptonuric ochronosis. The Journal of heart valve disease, 2002, Volume: 11, Issue:3 Topics: Aged; Alkaptonuria; Aortic Valve Stenosis; Family Health; Female; Genetic Predisposition to Disease; Humans; Ochronosis; Tyrosine	2002
Tyrosine metabolism in cirrhosis: acquired alkaptonuria. Surgical forum, 1978, Volume: 29 Topics: Alkaptonuria; Homogentisic Acid; Humans; Liver Cirrhosis; Liver Function Tests; Phenylpyruvic Acids; Tyrosine	1978
[Alkaptonuric ochronosis]. Die Medizinische Welt, 1975, Feb-28, Volume: 26, Issue:9 Topics: Alkaptonuria; Cartilage Diseases; Cartilage, Articular; Humans; Joint Diseases; Male; Middle Aged; Ochronosis; Synovial Membrane; Tyrosine	1975
Intermittent alcaptonuria. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1975, Volume: 58, Issue:5 Topics: Alkaptonuria; Child; Homogentisic Acid; Humans; Male; Oxygenases; Phenylalanine; Tyrosine	1975
[Research on the excretion of urinary homogentisic acid by heterozygotes for alkaptonuria]. Enzymologia biologica et clinica, 1968, Volume: 9, Issue:1 Topics: Adult; Aged; Alkaptonuria; Chromatography, Thin Layer; Female; Genes, Recessive; Heterozygote; Homozygote; Humans; Kidney Function Tests; Male; Middle Aged; Phenylacetates; Silicon Dioxide; Tyrosine	1968
[Hereditary amino acid metabolism disorders. Indications for early diagnosis]. Fortschritte der Medizin, 1972, Apr-13, Volume: 90, Issue:11 Topics: Albinism; Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Amino Acids; Arginine; Cystathionine; Cystinosis; Diagnosis, Differential; Glycine; Hartnup Disease; Histidine; Homocystinuria; Humans; Infant; Infant, Newborn; Maple Syrup Urine Disease; Methods; Methylmalonic Acid; Phenylketonurias; Proline; Propionates; Tyrosine	1972
[Diagnosis of inborn amino acid metabolism errors. Important symptoms and laboratory methods]. Fortschritte der Medizin, 1972, Apr-13, Volume: 90, Issue:11 Topics: Albinism; Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Amino Acids; Arginine; Clinical Laboratory Techniques; Cystathionine; Cystinosis; Glycine; Hartnup Disease; Histidine; Homocystinuria; Humans; Maple Syrup Urine Disease; Methods; Methylmalonic Acid; Phenylketonurias; Proline; Propionates; Tyrosine	1972
[Letter: Red-staining of diapers by urine]. Die Medizinische Welt, 1974, Jan-11, Volume: 25, Issue:2 Topics: Alkaptonuria; Bedding and Linens; Humans; Infant; Porphyrins; Proteinuria; Tyrosine; Uric Acid; Urine	1974
The investigation of aromatic acids in phenylketonuria, alkaptonuria and tyrosinosis using gas-liquid chromatography. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 37 Topics: Acetates; Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Chemistry, Clinical; Chromatography, Gas; Diet Therapy; Ethanol; Hippurates; Homogentisic Acid; Humans; Lactates; Mandelic Acids; Methods; Phenols; Phenylacetates; Phenylketonurias; Phenylpyruvic Acids; Tyrosine	1972
[Alkaptonuria and ochronosis]. Deutsche medizinische Wochenschrift (1946), 1972, Feb-18, Volume: 97, Issue:7 Topics: Alkaptonuria; Chemical Phenomena; Chemistry; Diagnosis, Differential; Female; Germany, West; Homogentisic Acid; Humans; Male; Middle Aged; Ochronosis; Phenols; Phenylalanine; Radiography; Sex Factors; Spinal Diseases; Tyrosine	1972
Decreased binding of 14C-homogentisic acid induced by ascorbic acid in connective tissue of rats with experimental alcaptonuria. Nature, 1970, Nov-21, Volume: 228, Issue:5273 Topics: Alkaptonuria; Ascorbic Acid; Binding Sites; Carbon Isotopes; Connective Tissue; Disease Models, Animal; Ochronosis; Penicillamine; Phenylacetates; Sternum; Tendons; Tyrosine	1970
An autopsy case of alkaptonuria with ochronosis. Acta pathologica japonica, 1970, Volume: 20, Issue:4 Topics: Alkaptonuria; Autopsy; Brain; Humans; Intervertebral Disc; Kidney; Liver; Male; Middle Aged; Mixed Function Oxygenases; Myocardium; Ochronosis; Organ Size; Oxygenases; Pedigree; Pigments, Biological; Skin; Spine; Tyrosine	1970
Gas chromatographic measurement of phenolic acids and alcohols in human urine. Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 20, Issue:3 Topics: Adult; Alkaptonuria; Chromatography, Gas; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mandelic Acids; Methods; Neuroblastoma; Phenols; Phenylacetates; Phenylketonurias; Pheochromocytoma; Silicones; Tyrosine	1968
Studies on urinary phenolic compounds in man. IV. O-Tyrosine and its metabolites. Scandinavian journal of clinical and laboratory investigation, 1966, Volume: 18, Issue:2 Topics: Alkaptonuria; Humans; In Vitro Techniques; Lactates; Male; Phenylacetates; Phenylalanine; Tyramine; Tyrosine	1966
Experimental ochronosis. Induction in rats by long-term feeding with L-tyrosine. Archives of pathology, 1966, Volume: 82, Issue:1 Topics: Alkaptonuria; Animals; Cartilage, Articular; In Vitro Techniques; Knee Joint; Male; Ochronosis; Phenylacetates; Pigmentation Disorders; Rats; Tyrosine	1966