tyrosine has been researched along with Aging in 345 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (25.80) | 18.7374 |
| 1990's | 62 (17.97) | 18.2507 |
| 2000's | 114 (33.04) | 29.6817 |
| 2010's | 68 (19.71) | 24.3611 |
| 2020's | 12 (3.48) | 2.80 |
| Authors | Studies |
|---|---|
| Garg, G; Rizvi, SI; Singh, AK; Singh, S; Verma, AK | 1 |
| Arenas-Ríos, E; Arteaga-Silva, M; Ávalos-Rodríguez, A; Cortés-Barberena, E; Konigsberg, M; López-Trinidad, BP; Rodríguez-Tobón, A; Vigueras-Villaseñor, RM | 1 |
| Hu, D; Hu, L; Jiao, DL; Ju, XY; Li, GN; Li, X; Liu, SM; Ma, BZ; Qi, L; Si, SH; Zhao, C; Zhao, SY; Zhou, S | 1 |
| Krajek, AC; Lang, JA; Rand, JE; Schwartz, KS | 1 |
| Botta, A; Dadlani, H; Elango, R; Ghosh, S; Jiayu, Y; Rasmussen, B; Renaud, LM; Simtchouk, S; Winkler, J | 1 |
| Inoue, H; Ishibashi, T; Itabe, H; Kamioka, M; Koyama, H; Ohkawara, H; Ohtsuka, S; Shiomi, M; Sugimoto, K; Uekita, H; Wada, I; Yamagishi, S; Yamamoto, H; Yasuchika, T | 1 |
| Bai, P; Chen, F; Chen, J; Li, M; Mao, D; Wang, R; Yang, L; Yang, X; Zhang, Y; Zhao, W | 1 |
| Brunt, VE; Casso, AG; Davy, KP; Gioscia-Ryan, RA; Neilson, AP; Richey, JJ; Sapinsley, ZJ; Seals, DR; VanDongen, NS; Ziemba, BP; Zigler, MC | 1 |
| Chen, P; Li, X; Liang, G; Ling, X; Shi, Z; Wang, F; Wei, M; Zhang, J; Zhang, T; Zhao, C | 1 |
| Asara, JM; Binari, R; Brockmann, A; Cracan, V; Filine, E; Leshchiner, D; Olsen, AL; Parkhitko, AA; Perrimon, N; Rabinowitz, JD; Ramesh, D; Wang, L | 1 |
| Bailey, WM; Gensel, JC; McFarlane, KE; Patel, SP; Slone, SA; Stewart, AN; Sullivan, PG; Tranthem, LA; Vekaria, HJ; Zhang, B | 1 |
| Hasan, M; Jung, BH; Kwon, OS; Lee, G; Lee, SH; Seo, JE | 1 |
| Alfano, R; Balta, C; Cotoraci, C; D'Amico, M; Galdiero, M; Gesualdo, C; Gharbia, S; Gherghiceanu, M; Herman, H; Hermenean, A; Mladin, B; Peteu, VE; Petrillo, F; Rossi, S; Trotta, MC | 1 |
| Chang, F; Flavahan, NA; Flavahan, S | 1 |
| Damanhuri, HA; Durani, LW; Hamezah, HS; Ibrahim, NF; Makpol, S; Tooyama, I; Yanagisawa, D | 1 |
| Aarts, E; Bloemendaal, M; de Heus, R; van de Rest, O | 1 |
| Brandmaier, AM; Colzato, L; Düzel, S; Gallinat, J; Kühn, S; Lindenberger, U; Norman, K; Widaman, KF | 1 |
| Liu, HM; Liu, JD; Ma, N; Wang, XZ; Xia, T | 1 |
| Dodos, M; Janssen, WG; Mazid, S; McEwen, BS; Milner, TA; Morrison, JH; Puri, R; Waters, EM | 1 |
| Breevoort, SR; Dobson, PS; Donato, AJ; Durrant, JR; Islam, MT; Lesniewski, LA; Liu, Y; Machin, DR; Meza, AJ; Nielson, EI; Walker, AE | 1 |
| Eisenhofer, G; Huebner, A; Mangelis, A; Peitzsch, M | 1 |
| Bůžková, P; Carbone, LD; Coughlin, SS; Fink, HA; Isales, CM; Le, B; Raiford, M; Robbins, JA; Shikany, JM | 1 |
| Ari, N; Aydin, E; Cumaoğlu, A; Dilsiz, N; Karasu, C; Sakul, A | 1 |
| Jeon, JH; Jeong, E; Kim, HC; Kim, IB; Park, YJ; Sim, S; Yang, MJ | 1 |
| Iida, A; Miyauchi, H; Muramatsu, S; Shimazaki, K; Takino, N | 1 |
| Bai, L; Ding, J; Gao, J; Gu, M; Marshall, C; Miao, D; Shen, L; Wu, T; Xiao, M | 1 |
| Baltanás, A; Fortuño, A; Galindo, MF; Jordán, J; Solesio, ME; Zalba, G | 1 |
| Brewer, LD; Butterfield, DA; Cai, J; Förster, S; Keeney, JTR; Klein, JB; Latimer, CS; Porter, NM; Sultana, R | 1 |
| Dedola, GL; Farina, V; Giua, S; Lepore, G; Mura, E; Zedda, M | 1 |
| Han, L; Li, MG; Ye, P | 1 |
| Chen, L; Cheng, S; Fan, Q; Lau, WB; Li, F; Liu, JH; Wang, le F | 1 |
| Bramwell, RC; Donato, AJ; Enz, RA; Hart, CR; Hazra, S; Henson, GD; Layec, G; Lesniewski, LA; Morgan, RG; Reihl, KD; Richardson, RS; Trinity, JD; Walker, AE | 1 |
| Böhmová, A; Kačer, P; Kuzma, M; Mikoška, M; Pelclová, D; Syslová, K | 1 |
| Kim, SH; Lee, JH; Park, JY; Park, S | 1 |
| Jackson, MJ; McArdle, A; Pearson, T | 1 |
| Cawston, TE; Hui, W; Proctor, CJ; Rowan, AD; Xu, X; Young, DA | 1 |
| Kuwahira, I; Nagai, H; Nara, A; Ogura, S; Shimosawa, T; Shintani-Ishida, K; Shirai, M; Yoshida, K | 1 |
| Alves, R; Andreotti, DZ; Böhmer, AE; de Sá Lima, L; Kawamoto, EM; Kinoshita, PF; Marcourakis, T; Marques Orellana, AM; Scavone, C; Vasconcelos, AR; Yshii, LM | 1 |
| Biswal, S; Chen, H; Guo, J; Jin, S; Kombairaju, P; Zirkin, BR | 1 |
| Calabrese, EJ; Calabrese, V; Dattilo, S; Ferreri, T; Graziano, A; Koverech, G; Maiolino, L; Monte, I; Parenti, R; Pennisi, M; Petralia, A | 1 |
| Baur, JA; Becker, LB; Bhatti, T; Guan, Y; Karamercan, MA; Sims, CA; Wang, H; Ye, L | 1 |
| Chun, Y; Kim, CS; Kim, HJ; Kim, J; Park, S; Song, W | 1 |
| Hirobe, T; Ishikawa, A | 1 |
| Fisher, AL; Ipson, BR | 1 |
| Bloch, W; Labbé, D; Michel, O; Schick, B | 1 |
| Ban, TH; Chang, YS; Choi, BS; Jang, IA; Kim, EN; Kim, MY; Lim, JH; Park, CW; Shin, SJ; Yoon, HE | 1 |
| Barbosa, RM; Dias, C; Ferreiro, E; Laranjinha, J; Ledo, A; Lourenço, CF | 1 |
| Butterfield, DA; Ceddia, MA; Farr, SA; Feng, S; Herrlinger, KA; Lewis, BJ; Morley, JE; Niehoff, ML; Welleford, A | 1 |
| Del Moral, ML; Molina, F; Peinado, MÁ; Rus, A | 1 |
| Chakravarti, B; Chakravarti, DN | 1 |
| Collier, TJ; Kanaan, NM; Kordower, JH | 1 |
| Babusikova, E; Dobrota, D; Jesenak, M; Kaplan, P; Racay, P | 1 |
| Chen, CN; Ferrington, DA; Thompson, LV | 1 |
| Alway, SE; Pistilli, EE; Siu, PM | 1 |
| Cha, CI; Cho, YW; Huh, Y; Lee, JJ; Yeo, SG | 1 |
| Carter, R; Gay, L; Geor, R; Treiber, K; Williams, C | 1 |
| Anderson, MC; Connell, ML; Donato, AJ; Durrant, JR; Folian, BJ; Lesniewski, LA; Seals, DR | 1 |
| Beske, SD; Lawson, BR; Lesniewski, LA; Pierce, GL; Seals, DR | 1 |
| Boveris, A; Cadenas, E; Hamilton, RT; Lam, PY; Yin, F | 1 |
| Auten, KM; Auten, RL; Brahmajothi, M; Mason, SN | 1 |
| Connell, ML; Donato, AJ; Durrant, JR; Folian, BJ; Lawson, BR; Lesniewski, LA; Russell, MJ; Seals, DR | 1 |
| Cho, JH; Choi, JH; Hwang, IK; Lee, CH; Lee, YL; Park, CW; Park, OK; Shin, HC; Won, MH; Yoo, KY | 1 |
| Kang, LS; Muller-Delp, JM; Reyes, RA | 1 |
| Denvir, MA; Gray, GA | 1 |
| Huang, A; Kaley, G; Sun, D; Yang, YM | 1 |
| Bordin, L; Bragadin, M; Brunati, AM; Clari, G; Fiore, C | 1 |
| Chen, L; Feany, MB; Hyman, BT; McLean, PJ; Negro, A; Periquet, M; Wang, X | 1 |
| Anniko, M; Hamamoto, T; Hirakawa, K; Ishibashi, T; Takumida, M | 1 |
| Gonzalez, L; Jiang, L; Ke, Z; Li, C; Li, W; Liu, Y; Yang, G; You, J; Yu, X; Yu, Y | 1 |
| Del Priore, LV; Dillon, J; Gaillard, ER; Murdaugh, LS; Wang, Z | 1 |
| Elfering, S; Fujisawa, Y; Giulivi, C; Haynes, V; Traaseth, NJ | 1 |
| Holowatz, LA; Kenney, WL; Lang, JA | 1 |
| Amaning, JK; Bailey, CE; DeFord, JH; Dimayuga, VL; Nuss, JE; Papaconstantinou, J; Rabek, JP | 1 |
| Betik, AC; Hepple, RT; Thomas, MM; Tupling, AR; Vigna, C | 1 |
| Huh, Y; Hwang, SJ | 1 |
| Cha, HN; Kim, JY; Kim, YD; Kim, YW; Min, KN; Park, SY; Song, IH | 1 |
| Baker, SL; Braskie, MN; Jagust, WJ; Landau, SM; Madison, CM; O'Neil, JP; Taylor, SD; Wilcox, CE | 1 |
| Folkmann, JK; Jacobsen, NR; Loft, S; Møller, P; Sheykhzade, M; Vesterdal, LK; Wallin, H | 1 |
| Evers, BM; Saito, H; Starr, ME; Ueda, J; Yamamoto, S | 1 |
| Brunk, UT; Dunlop, RA; Rodgers, KJ | 1 |
| Connell, ML; Donato, AJ; Durrant, JR; Folian, BJ; Lesniewski, LA; Seals, DR | 1 |
| Jackson, MJ; Kabayo, T; McArdle, A; McArdle, F; Palomero, J; Pye, D; Richardson, A; Sakellariou, GK; Tidball, JG; Van Remmen, H; Vasilaki, A; Zibrik, L | 1 |
| Bergantin, LB; Figueiredo, LB; Godinho, RO | 1 |
| Donato, AJ; Eskurza, I; LaRocca, TJ; Pierce, GL; Seals, DR; Silver, AE | 1 |
| Baylis, C; Moningka, NC; Muller-Delp, JM; Sindler, AL | 1 |
| Amaning, JK; Bailey, CE; Deford, JH; Dimayuga, VL; Farrar, R; Hammers, DW; Papaconstantinou, J | 1 |
| Bruno, MA; Cuello, AC | 1 |
| Boirie, Y; Guillet, C; Migné, C; Murakami, H; Salles, J; Tardif, N; Walrand, S | 1 |
| de Lange, A; Gijsen, AP; Groen, B; Pennings, B; Senden, JM; van Loon, LJ; Zorenc, AH | 1 |
| Feeney, MB; Schöneich, C | 1 |
| Aksenov, V; Liu, J; Long, J; Rollo, CD | 1 |
| Bridenbaugh, EA; Gashev, AA; Thangaswamy, S | 1 |
| Dodson, RB; Eng, JS; Fleenor, BS; Nair, DP; Seals, DR; Sindler, AL | 1 |
| Dussault, S; Groleau, J; Haddad, P; Maingrette, F; Perez, G; Rivard, A; Turgeon, J | 1 |
| Davidge, ST; Jiang, Y; Lekontseva, O; Schleppe, C | 1 |
| Ammassari-Teule, M; Barbagallo, AP; Biundo, F; Canu, N; D'Adamio, L; La Rosa, LR; Lombino, F; Luvisetto, S; Matrone, C; Pignataro, A; Tamayev, R; Yang, L; Zheng, H | 1 |
| Fleenor, BS; Howell, KL; Marvi, NK; Seals, DR; Sindler, AL; Yoshizawa, M; Zigler, ML | 1 |
| Chakravarti, B; Chakravarti, DN; Lutfeali, R; Marshall, A; Raval, A | 1 |
| Brink, PR; Glass, PS; Liu, L; Rebecchi, MJ; Wang, Q; Zhu, J | 1 |
| Vaziri, ND; Wang, HW; Wang, XQ; Zhang, J; Zhou, XJ | 1 |
| Cha, CI; Chung, YH; Joo, KM; Kim, MJ; Shin, CM | 1 |
| Carlson, CS; Cole, A; Del Carlo, M; Loeser, RF | 1 |
| Ferrington, DA; Kapphahn, RJ; Louie, JL | 1 |
| Bondy, SC; Ni, Z; Sharman, EH; Sharman, KG; Vaziri, ND | 1 |
| Abdel-Mageed, AB; Armstrong, JS; Biggerstaff, J; Bivalacqua, TJ; Champion, HC; Hellstrom, WJ; Kadowitz, PJ | 1 |
| Akçay, T; Cakatay, U; Kayali, R; Sivas, A; Tekeli, F; Telci, A | 2 |
| Curfs, JH; Kuijpers, W; Peters, TA; Tonnaer, EL | 1 |
| Abdalla Saad, MJ; Alvarez-Rojas, F; Carvalheira, JB; Carvalho, CR; Dolnikoff, MS; Hirata, AE | 1 |
| Debrabander, A; Dobbelaere, D; Farriaux, JP; Gottrand, F; Michaud, L; Turck, D; Vanderbecken, S | 1 |
| WALIGORA, Z; WENDER, M | 1 |
| MARSDEN, CD | 1 |
| LABELLA, FS | 2 |
| KNOX, WE; LINDER, MC; LYNCH, RD; MOORE, CL | 1 |
| STEVEN, FS | 1 |
| Blomberg, BB; Riley, RL; Sherwood, EM; Van der Put, E | 1 |
| Aydar, Y; Balogh, P; Szakal, AK; Tew, JG | 1 |
| Arenas, IA; Armstrong, SJ; Davidge, ST; Pehowich, DJ; Xu, Y | 1 |
| Lindquist, M; Ponnappan, S; Ponnappan, U; Uken-Trebilcock, G | 1 |
| de Cabo, R; Ingram, DK; Lane, MA; Zhu, M | 1 |
| Banks, WA; Butterfield, DA; Calabrese, V; Farr, SA; Joshi, G; Morley, JE; Poon, HF; Sultana, R | 1 |
| Behring, A; Kanski, J; Pelling, J; Schöneich, C | 1 |
| Beitzel, F; Lynch, GS; Plant, DR; Ryall, JG; Schertzer, JD; Stupka, N | 1 |
| Bachschmid, M; Cosentino, F; delli Gatti, C; Francia, P; Lüscher, TF; Martin-Padura, I; Migliaccio, E; Pelicci, PG; Savoia, C; Schiavoni, M; Volpe, M | 1 |
| Bahr, BA; Blomgren, K; Hagberg, H; Shibata, M; Uchiyama, Y; Wang, X; Xu, F; Zhu, C | 1 |
| Barreca, A; Johansen, T; Laurino, C; Malmlöf, K | 1 |
| Chung, HY; Lee, J; Son, TG; Yu, BP; Zou, Y | 1 |
| Hong, SJ; Kanski, J; Schöneich, C | 1 |
| Love, PE; Mathis, MA; Pitcher, LA; Subramanian, S; van Oers, NS; Wakeland, EK; Young, JA | 1 |
| Aerni, A; Coluccia, D; de Quervain, DJ; Garcia, E; Henke, K; Hock, C; Huynh, KD; Monsch, AU; Nitsch, RM; Papassotiropoulos, A; Stähelin, HB; Wollmer, MA | 1 |
| Cui, L; Hutton, ML; Lee, G; Propst, JA; Vega, IE; Yen, SH | 1 |
| Bardsley, V; Fellows, IW; Jennings, BA; Lonsdale, R; Willis, G; Wimperis, JZ | 1 |
| Dremina, ES; Schöneich, C; Sharov, VS | 1 |
| Janik, B; Makarewicz, D; Zalewska, T; Ziemka-Nałecz, M | 1 |
| Bondy, CA; Cheng, CM; Matyakhina, L; Tseng, V; Wang, D; Wang, J | 1 |
| Bigelow, DJ; Knyushko, TV; Schöneich, C; Sharov, VS; Williams, TD | 1 |
| Dixit, V; Guo, X; Henderson, GN; James, MO; Liu, H; Shroads, AL; Stacpoole, PW | 1 |
| Adachi, T; Bigelow, D; Cohen, RA; Guo, W; Jiang, B; Knyushko, TV; Lazar, H; Menzoian, J; Schöneich, C; Sharov, V; Xu, S; Ying, J | 1 |
| Bachschmid, M; Hahn, R; Kilo, J; Labugger, R; Lüscher, TF; Palacios-Callender, M; Schildknecht, S; van der Loo, B | 1 |
| Douziech, N; Fortin, CF; Fulop, T; Larbi, A; Lesur, O | 1 |
| Doser, TA; Fang, CX; Janardhanan, R; Nunn, JM; Quinn, MT; Ren, J; Sreejayan, N; Yang, X; Zhu, M | 1 |
| Galeva, NA; Kanski, J; Schöneich, C; Sharov, VS; Williams, TD | 1 |
| Anantharaman, M; Keller, JN; Kiningham, KK; Markesbery, WR; Murphy, MP; St Clair, DK; Tangpong, J | 1 |
| Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A; Rigual, R | 1 |
| Ferrington, DA; Fugere, NA; Thompson, LV | 1 |
| Jiang, H; Schacht, J; Sha, SH; Talaska, AE | 1 |
| Gijsen, AP; Gorselink, M; Koopman, R; Manders, RJ; Pijpers, E; van Loon, LJ; Verdijk, L; Wagenmakers, AJ | 1 |
| Schöneich, C | 1 |
| Benito, M; Clampit, JE; Escribano, O; Gonzalez-Rodriguez, A; Rondinone, CM; Valverde, AM | 1 |
| Beller, CJ; Berger, I; Chen, SH; Gero, D; Groves, JT; Lin, LN; Radovits, T; Seres, L; Szabó, C; Szabó, G; Zotkina, J | 1 |
| Cristòfol, R; García-Matas, S; Pertusa, M; Rodríguez-Farré, E; Sanfeliu, C | 1 |
| Gokulrangan, G; Michaelis, ML; Schöneich, C; Zaidi, A | 1 |
| Barlow, PN; Blaum, BS; Deakin, JA; Egan, C; Ferreira, VP; Herbert, AP; Lyon, M; Pangburn, MK; Schmidt, CQ; Uhrín, D | 1 |
| Berger, I; Gero, D; Karck, M; Radovits, T; Seres, L; Szabó, C; Szabó, G | 1 |
| Fritsche, L; Hartmann, A; Heinen, S; Keilhauer, CN; Lauer, N; Schlötzer-Schrehardt, U; Skerka, C; Smith, R; Sühnel, J; Weber, BH; Weinberger, AA; Zipfel, PF | 1 |
| Donato, AJ; Eskurza, I; Gates, PE; Levy, AS; Pierce, GL; Seals, DR; Silver, AE | 1 |
| Besshoh, S; Brown, IR; Chen, S; Gurd, JW | 1 |
| Blanco, S; Castro, L; Del Moral, ML; Hernández, R; Martínez-Lara, E; Pedrosa, JA; Peinado, MA; Siles, E | 1 |
| Bellucci, A; Casamenti, F; Fiorentini, A; Grossi, C; Luccarini, I; Rosi, MC | 1 |
| Asano, S; Blough, ER; Desai, DH; Kakarla, S; Katta, A; Rice, KM; Walker, EM; Wehner, P | 1 |
| Cakatay, U; Genç, H; Kayali, R; Uzun, H | 1 |
| DeRuisseau, KC; DeRuisseau, LR; Jung, SH; Kavazis, AN | 1 |
| He, J; Li, X; Li, XM; Luo, H; Tempier, A; Wang, H; Wei, Z; Xu, H; Yan, B; Yu, Y; Zhang, Y | 1 |
| Bigelow, DJ | 1 |
| Fisher, AL; Lithgow, GJ; Nash, L; Page, KE | 1 |
| Barbieri, M; Crescenzi, B; D'Amico, M; Di Filippo, C; Ferraraccio, F; Laieta, MT; Marfella, R; Paolisso, G; Rossi, F; Sangiulo, P; Vestini, R | 1 |
| Kregel, KC; Oberley, TD; Swanlund, JM; Zhang, HJ | 1 |
| Zhinkin, LN | 1 |
| Dickson, IR; Happey, F; Naylor, A; Pearson, CH; Turner, RL | 1 |
| Greenland, RD; Lasley, SM; Michaelson, IA; Minnema, DJ | 1 |
| Chandra, SV; Dubey, MP; Shukla, GS | 1 |
| Marchington, DR; Shargill, NS; York, DA | 1 |
| Heishman, SJ; Thurmond, JB | 1 |
| Dickens, G; Guroff, G; Ikeno, T; Lloyd, T | 1 |
| Gregg, VA; Milligan, LP | 1 |
| Iriyama, K; Itoh, K; Iwamoto, T; Mizuno, A; Ozaki, Y; Yoshiura, M | 1 |
| Hedner, T; Lundborg, P | 1 |
| Schneider, AJ | 1 |
| Fish, I; Hochgeschwender, U; Samuels, S; Schwartz, SA | 1 |
| Bates, PC; Crie, JS; Griffin, EE; Millward, DJ; Wildenthal, K | 1 |
| Cooper, RL; Linnoila, M | 2 |
| Porter, JC; Reymond, MJ | 1 |
| Arce, CA; Barra, HS; Caputto, R | 1 |
| Ding, A; Hwang, S; Schwab, R | 1 |
| Chua-Couzens, J; Clary, DO; Holtzman, DM; Kaplan, DR; Knüsel, B; Kromer, LF; Li, Y; Mobley, WC | 1 |
| Aguirre, J; Armando, I; Barontini, M; Nowicki, S | 1 |
| Gilliland, LK; Grossmann, A; Jinneman, JC; Kanner, SB; Kavanagh, TJ; Ledbetter, JA; Rabinovitch, PS | 1 |
| Iwase, T; Kino, I; Naito, Y; Sugimura, H; Suzuki, M; Tanaka, M | 1 |
| Polk, DB | 1 |
| Balasubramanian, D; Luthra, M; Ranganathan, D; Ranganathan, S | 1 |
| Cybulsky, AV; Goodyer, PR; McTavish, AJ | 1 |
| Miller, RA; Shi, J | 2 |
| Arola, LI; Salvadó, MJ | 1 |
| Kamei, A | 1 |
| Bobek, P; Krajcovicová-Kudlácková, M; Ozdín, L | 1 |
| Greve, J; Otto, K; Puppels, GJ; Smeets, MH; Vrensen, GF | 1 |
| Kee, AJ; Smith, RC | 1 |
| Poddar, R; Sarkar, PK | 1 |
| Majumdar, AP; Wahby, M | 1 |
| Baynes, JW; Dyer, DG; Huggins, TG; Thorpe, SR; Wells-Knecht, MC | 1 |
| Faull, KF; Fisher, RS; Fluharty, AL; Gayek, RJ; Lazareff, JA; Olmstead, CE; Orlino, EN; Peacock, WJ; Wehby-Grant, MC | 1 |
| Majumdar, AP; Malecka-Panas, E; Relan, NK | 1 |
| Bigelow, DJ; Ferrington, DA; Hühmer, AF; Schöneich, C; Viner, RI | 1 |
| Cano, J; de la Cruz, CP; Machado, A; Revilla, E; Rodríguez-Gómez, JA; Steffen, V | 1 |
| Harris, N; Milakofsky, L; Vogel, WH | 1 |
| Chevalier, B; Duclos, MJ; Goddard, C; Remignon, H; Ricard, FH; Simon, J | 1 |
| Garcia, GG; Miller, RA | 2 |
| Chao, CC; Ma, YS; Stadtman, ER | 1 |
| Ahlrichs, JA; Denne, SC; Karn, CA; Leitch, CA; Liechty, EA; Poindexter, BB; Wang, J | 1 |
| Arnold, LA; Bebin, EM; Fryburg, JS; Gunasekera, RS; Hyland, K; Jacobson, RD; Rost-Ruffner, E; Trugman, JM; Wilson, WG | 1 |
| Chan, VW; DeFranco, AL; Lowell, CA; Meng, F; Soriano, P | 1 |
| Dewhirst, MW; Greenberg, CS; Haroon, ZA; Peters, KG; Werner, S; Wong, AL | 1 |
| Heinecke, JW; Holloszy, JO; Leeuwenburgh, C; Sohal, RS; Wagner, P | 1 |
| Hansen, P; Heinecke, JW; Holloszy, JO; Leeuwenburgh, C; Shaish, A | 1 |
| Harris, MD; Pahlavani, MA; Richardson, A | 1 |
| Gao, J; Squier, TC; Williams, TD; Yao, Y; Yin, D | 1 |
| Lipschitz, D; Ponnappan, U; Tinkle, CW | 1 |
| Abraham, GN; Chakravarti, B; Chakravarti, DN; Devecis, J; Seshi, B | 1 |
| Babst, R; Bongiorno, L; Marini, M; Marzano, M; Roda, LG; Spagnoli, G; Urbani, A | 1 |
| Dunah, AW; Wolfe, BB; Yasuda, RP | 1 |
| Alonso, D; Barroso, JB; Bentura, ML; Campbell, RO; Esteban, FJ; Fernández, AP; Leza, JC; Lizasoain, I; Martínez-Murillo, R; Moro, MA; Pedrosa, JA; Peinado, MA; Richart, A; Rodrigo, J; Santacana, M; Serrano, J; Uttenthal, LO; Valderrama, R | 1 |
| Hashizume, Y; Kato, Y; Maruyama, W; Naoi, M; Osawa, T | 1 |
| Hansen, PA; Heinecke, JW; Holloszy, JO; Leeuwenburgh, C | 1 |
| Bignami, F; Camus, G; Cartaud, A; Cartaud, J; Ludosky, MA; Marchand, S | 1 |
| Palmer, HJ; Paulson, KE; Tuzon, CT | 1 |
| Bigelow, DJ; Ferrington, DA; Schöneich, C; Viner, RI; Williams, TD | 1 |
| Arcand, M; Desgeorges, S; Dupuis, G; Fülöp, T; Gagné, D; Goulet, AC; Lacombe, G | 1 |
| Anthony, M; Honse, Y; Qiao, G; Sun, L; Willis, R | 1 |
| Chen, M; Liu, B; Newhouse, YG; Whisler, RL | 1 |
| Li, M; Sierra, F; Torres, C; Walter, R | 1 |
| Brenelli, SL; Carvalho, CR; Maeda, L; Saad, MJ | 1 |
| Ando, K; Beppu, M; Hayakawa, M; Hiramoto, K; Kikugawa, K; Nakauchi, K | 1 |
| Saha, S; Slepecky, NB | 1 |
| Abe, T; Ishizaki, E; Isobe, C; Murata, T; Tohgi, H; Yamazaki, K | 1 |
| Fernstrom, JD | 1 |
| Carvalho, E; Rondinone, C; Smith, U | 1 |
| Berry, SA; Frick, GP; Goodman, HM; Gruppuso, PA; Phornphutkul, C | 1 |
| Dejesus, OT; Endres, CJ; Holden, JE; Nickles, RJ; Shelton, SE | 1 |
| Bachschmid, M; Erusalimsky, JD; Gygi, D; Kilo, J; Labugger, R; Lüscher, TF; Malinski, T; Palacios-Callender, M; Powell, JM; Quaschning, T; Skepper, JN; Ullrich, V; van der Loo, B | 1 |
| Bickford, PC; Kaufmann, JA; Taglialatela, G | 1 |
| Ferrini, M; González-Cadavid, NF; Magee, TR; Rajfer, J; Vernet, D | 1 |
| De Boever, J; De Creus, A; Debacker, V; Leclercq, G; Plum, J; Stevenaert, F; Van Beneden, K | 1 |
| Boland, R; de Boland, AR; Gentili, C | 1 |
| Kawano, H; Matsushita, H; Ochi, M; Sakai, H; Takeuchi, Y | 1 |
| Ferrini, M; Gonzalez-Cadavid, NF; Rajfer, J; Sinha Hikim, AP; Swerdloff, RS; Wang, C | 1 |
| Duff, K; La Francois, J; Matsuoka, Y; Picciano, M | 1 |
| Davies, SM; Duncan, MW; Murphy, MP; Poljak, A; Smythe, GA | 1 |
| Desgeorges, S; Douziech, N; Dupuis, G; Fülöp, T; Goulet, AC; Lacombe, G; Linteau, A | 1 |
| Ali, SF; Imam, SZ | 1 |
| Bendinelli, P; Maroni, P; Piccoletti, R; Schiaffonati, L; Tiberio, L | 1 |
| Ariga, K; Myoui, A; Nakase, T; Okuda, S; Yonenobu, K; Yoshikawa, H | 1 |
| Dillon, J; Galicia, E; Paik, DC; Tilson, MD | 1 |
| Baskerville, KA; Bryan, D; Gallagher, M; Gonzalez, J; Lund, K; McKinney, M; Nicolle, MM; Sugaya, K | 1 |
| Abraham, GN; Chakravarti, B | 1 |
| Eckert, A; Fröhlich, L; Maurer, K; Müller, WE; Schindowski, K | 1 |
| Stadtman, ER | 1 |
| De, CR; Landolfi, R; Marchioli, R; Rocca, B | 1 |
| Cha, CI; Chung, YH; Kim, EG; Kim, MJ; Lee, EY; Shin, CM | 1 |
| Drew, B; Leeuwenburgh, C | 1 |
| Courtois, Y; Goureau, O; Sennlaub, F | 1 |
| Dong, LQ; Guo, Z; Lim, MA; Liu, F; Ramos, FJ; Richardson, A; Strong, R; Wick, MJ | 1 |
| Csiszar, A; Edwards, JG; Kaley, G; Kaminski, P; Koller, A; Ungvari, Z; Wolin, MS | 1 |
| Hosbach, HA; Kubli, E | 1 |
| Khvisiuk, NI; Timoshenko, OP | 1 |
| Ledvina, M; Malaník, V | 1 |
| Sandberg, LB | 1 |
| Adelman, RC; Roth, GS | 1 |
| Benignus, VA; Davis, JN; McNamara, MC; Miller, AT | 1 |
| Barr-Nea, L; Wolman, M | 1 |
| Gemant, A | 1 |
| Dunlop, D; Lajtha, A; Patlak, C; Toth, J | 1 |
| Bertolini, AM; Santagostino, A | 1 |
| Berry, HK; Butcher, RE; Kazmaier-Novak, KJ; Kindt, CW; Vorhees, CV | 1 |
| Algeri, S; Brunello, N; Ponzio, F | 1 |
| Borisy, GG; Rodriguez, JA | 1 |
| Daniel, PM; Moorhouse, SR; Pratt, OE | 1 |
| Carlsson, A | 1 |
| Bozcuk, AN | 1 |
| Goldspink, DF; Goldspink, G | 1 |
| Dobbing, J; Pickard, FJ; Tricklebank, MD | 1 |
| Bondy, SC; Purdy, JL | 1 |
| Alper, A; Dougher, GJ; Finch, CE; Hody, G; Jonec, V; Morton-Smith, W; Walker, JP | 1 |
| Flavin, M; Raybin, D | 1 |
| Finch, CE; Jonec, V | 1 |
| Bayomi, RA; Smith, WR | 1 |
| Cohen, O; Nadiv, O; Zick, Y | 1 |
| Afonso, D; Arevalo, R; Rodriguez, M; Santana, C | 1 |
| Ingram, RL; Lenham, JE; Sonntag, WE | 1 |
| Baynes, JW; Detorie, NJ; Dyer, DG; Huggins, TG; Staton, MW; Thorpe, SR; Walla, MD | 1 |
| Fligiel, SE; Hatfield, JS; Jasti, S; Majumdar, AP; Tureaud, J | 1 |
| Abe, T; Takahashi, S | 1 |
| Breckenridge, MB; Grants, IS; Liu, BQ; Newhouse, YG; Walters, JD; Whisler, RL | 1 |
| Abbasi, AA; Chaudry, F; Mattson, DE; Rudman, D | 1 |
| Clavel, MC; Faivre-Sarrailh, C; Rabié, A | 1 |
| Cheng, N; Sahyoun, N | 1 |
| Bassant, MH; Godefroy, F; Lamour, Y; Sarhan, H; Weil-Fugazza, J | 1 |
| Chen, TS; Currier, GJ; Wabner, CL | 1 |
| Geesin, JC; Gordon, JS; Gracy, RW; Jacobson, TM; Lane, AT; Yüksel, KU | 1 |
| Tillotson, ML; Wood, JG | 1 |
| Haworth, SG; Polak, JM; Wharton, J | 1 |
| Alonso, AC; Arce, CA; Barra, HS | 1 |
| Goto, S; Takahashi, R | 1 |
| Barron, BC; Kuck, JF; Yu, NT | 1 |
| Navab, F; Winter, CG | 1 |
| Aragon, MC; Diez-Guerra, J; Gimenez, C; Herrero, E; Valdivieso, F | 1 |
| Bessems, GJ; Hoenders, HJ | 1 |
| Semensi, V; Sugumaran, M | 1 |
| Kochel, RL; Lloyd, T; Weinstein, JM | 1 |
| Kraus, H | 1 |
| Davey, KG; Huebner, E; Tobe, SS | 1 |
| Anderson, TJ; Ewen, SW | 1 |
| Gutmann, E; Hájek, I; Syrový, I | 2 |
| Angelakos, ET; Bajusz, E; Carballo, LC; Daniels, JB; King, MP | 1 |
| Jakubiec-Puka, A; Mochnacka, I | 1 |
| Behrman, RE; Fellman, JH; Jones, RT; Koler, RD; Vanbellinghen, PJ | 1 |
| Rauch, H; Siegel, SJ | 1 |
| Benda, P; Bourgoin, S; Faivre-Bauman, A; Glowinski, J; Hamon, M | 1 |
| Deyl, Z; Vanćiková, O | 1 |
| Franklin, EC; Rosenthal, CJ | 1 |
| de Jong, W; Provoost, AP; van Ree, JM; Versteeg, DH | 1 |
| Hornykiewicz, O; Lloyd, KG | 1 |
| Finch, CE | 1 |
| Bemiller, JN; Hoffmann, WE; Pappelis, AJ | 1 |
| Arcce, CA; Barra, HS; Caputto, R; Rodriguez, JA | 1 |
| Copius Peereboom, JW | 1 |
| Geison, RL; Josephson, L | 1 |
| De Luca, F; Macaione, S; Ruggeri, P; Tucci, G | 1 |
| Ilan, J | 1 |
| Pomerantz, SH | 1 |
| Dapson, RW; Irland, JM | 1 |
| Phillips, J; Sager, R; Tocci, PM | 1 |
| Murayama, K | 1 |
| Burzynski, NJ | 1 |
| Graeber, W | 1 |
| Horecker, BL; Koida, M; Lai, CY | 1 |
| Peereboom, JW | 1 |
| Ignarro, LJ; Shideman, FE | 1 |
| Mauldin, JK; Mitlin, N; Wiygul, G | 1 |
| Clarke, JT; Lowden, JA | 1 |
| Berman, MD; Kotula, AW | 1 |
11 review(s) available for tyrosine and Aging
| Article | Year |
|---|---|
Multimarker screening of oxidative stress in aging.
Topics: Aging; Biomarkers; Dinoprost; DNA Damage; Guanosine; Humans; Oxidative Stress; Proteins; Tyrosine | 2014 |
Analytical approaches to the diagnosis and treatment of aging and aging-related disease: redox status and proteomics.
Topics: Age Factors; Aging; Animals; Biomarkers; Disease Susceptibility; Glutathione; Humans; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Phenotype; Predictive Value of Tests; Protein Carbonylation; Proteins; Proteomics; Risk Factors; Tyrosine | 2015 |
Roles of the tyrosine isomers meta-tyrosine and ortho-tyrosine in oxidative stress.
Topics: Aging; Animals; Biomarkers; Isomerism; Oxidative Stress; Tyrosine | 2016 |
Protein Tyrosine Nitration: Role in Aging.
Topics: Age Factors; Aging; Animals; Brain; Humans; Liver; Myocardium; Nitrosative Stress; Oxidative Stress; Protein Conformation; Protein Processing, Post-Translational; Proteomics; Reactive Nitrogen Species; Reactive Oxygen Species; Structure-Activity Relationship; Tyrosine | 2017 |
Tyrosine modifications in aging.
Topics: Aging; Atherosclerosis; Cataract; Humans; Nerve Degeneration; Oxidative Stress; Protein Processing, Post-Translational; Proteins; Structure-Activity Relationship; Tyrosine | 2012 |
Protein modification in aging: an update.
Topics: Aging; Histidine; Humans; Lamin Type A; Neurodegenerative Diseases; Nuclear Proteins; Oxidation-Reduction; Progeria; Protein Precursors; Protein Processing, Post-Translational; Pyruvaldehyde; Transglutaminases; Tyrosine | 2006 |
Nitrotyrosine-modified SERCA2: a cellular sensor of reactive nitrogen species.
Topics: Aging; Animals; Biosensing Techniques; Energy Metabolism; Humans; Models, Molecular; Muscles; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Reactive Nitrogen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2009 |
Can nutrient supplements modify brain function?
Topics: Aging; Animals; Brain; Diet; Dietary Supplements; Fatty Acids, Unsaturated; Folic Acid; Hematinics; Humans; Nutritional Physiological Phenomena; Tryptophan; Tyrosine | 2000 |
Protein oxidation in aging and age-related diseases.
Topics: Aging; Amino Acids; Animals; Antioxidants; Apoptosis; Cross-Linking Reagents; Cysteine; Disease; Humans; Longevity; Methionine; Models, Biological; Nitric Oxide; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptides; Peroxynitrous Acid; Protein Denaturation; Proteins; Rats; Reactive Oxygen Species; Tyrosine | 2001 |
Aging and the role of reactive nitrogen species.
Topics: Aging; Animals; Diet; Humans; Molecular Structure; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteins; Reactive Nitrogen Species; Tyrosine | 2002 |
Elastin structure in health and disease.
Topics: Aging; Amino Acid Sequence; Amino Acids; Animals; Arteriosclerosis; Calcium; Cholesterol; Copper; Cyanogen Bromide; Desmosine; Diet; Elastin; Microbial Collagenase; Models, Chemical; Molecular Weight; Protein Conformation; Swine; Tyrosine | 1976 |
6 trial(s) available for tyrosine and Aging
| Article | Year |
|---|---|
Oral L-Tyrosine Supplementation Improves Core Temperature Maintenance in Older Adults.
Topics: Adult; Aged; Aged, 80 and over; Aging; Body Temperature Regulation; Cold Temperature; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Skin; Skin Temperature; Tyrosine; Vasoconstriction; Young Adult | 2020 |
Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aging; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Tyrosine; Young Adult | 2017 |
Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.
Topics: Administration, Oral; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Endothelium, Vascular; Female; Humans; I-kappa B Proteins; Male; Middle Aged; NADPH Oxidases; NF-kappa B; NF-KappaB Inhibitor alpha; Obesity; Overweight; Oxidative Stress; Salicylates; Tyrosine; Vasodilation | 2009 |
Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men.
Topics: Aged; Aging; Algorithms; Amino Acids; Blood Glucose; Carbon Isotopes; Deuterium; Digestion; Humans; Insulin; Intestinal Absorption; Kinetics; Male; Milk Proteins; Muscle Proteins; Oxidation-Reduction; Phenylalanine; Postprandial Period; Quadriceps Muscle; Tyrosine; Whey Proteins | 2012 |
Evaluation of nutritional status and pathophysiology of growth retardation in patients with phenylketonuria.
Topics: Aging; Anthropometry; Body Composition; Body Height; Body Weight; Child; Child, Preschool; Chromatography, Gas; Cross-Sectional Studies; Diet; Erythrocytes; Female; Growth Disorders; Hormones; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Nutritional Status; Phenylalanine; Phenylketonurias; Thyroid Hormones; Trace Elements; Tyrosine | 2003 |
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.
Topics: Activities of Daily Living; Adult; Aged; Aging; Carbon Isotopes; Cross-Over Studies; Dietary Carbohydrates; Dietary Proteins; Double-Blind Method; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Tyrosine | 2006 |
328 other study(ies) available for tyrosine and Aging
| Article | Year |
|---|---|
Whey protein concentrate protects against age-dependent alteration in redox biomarkers.
Topics: Aging; Animals; Biomarkers; Cysteine; Drug Evaluation, Preclinical; Erythrocytes; Glycation End Products, Advanced; Lipid Metabolism; Male; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; Tryptophan; Tyrosine; Whey Proteins | 2020 |
Alterations in epididymal sperm maturation caused by ageing.
Topics: Aging; Animals; Epididymis; Male; Phosphorylation; Rats; Rats, Wistar; Sperm Maturation; Spermatozoa; Testosterone; Tyrosine | 2021 |
Identification of a hippocampal lncRNA-regulating network in a natural aging rat model.
Topics: Aging; Animals; Gene Regulatory Networks; Hippocampus; MicroRNAs; Peroxisome Proliferator-Activated Receptors; Rats; Reproducibility of Results; RNA, Long Noncoding; RNA, Messenger; Tumor Suppressor Protein p53; Tyrosine | 2022 |
Egg white consumption increases GSH and lowers oxidative damage in 110-week-old geriatric mice hearts.
Topics: Aging; Aldehydes; Amino Acids, Sulfur; Animal Feed; Animals; Antioxidants; Egg White; Glutathione; Glutathione Synthase; Inflammation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress; Tyrosine | 2020 |
Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis.
Topics: Aging; Animals; Antigens, Neoplasm; Atherosclerosis; Disease Models, Animal; Female; Gene Knockdown Techniques; Glycation End Products, Advanced; Humans; Hyperlipidemias; Immunohistochemistry; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Plaque, Atherosclerotic; Rabbits; Receptor for Advanced Glycation End Products; Tyrosine | 2019 |
Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.
Topics: Aged; Aging; Amino Acids; Body Weight; China; Dietary Proteins; Energy Intake; Energy Metabolism; Female; Humans; Male; Nutritional Requirements; Oxidation-Reduction; Phenylalanine; Recommended Dietary Allowances; Tyrosine | 2020 |
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
Topics: Acetylcholine; Adolescent; Adult; Aged; Aging; Animals; Antioxidants; Ascorbic Acid; Brachial Artery; Carotid Arteries; Cyclic N-Oxides; Dietary Supplements; Endothelium, Vascular; Gastrointestinal Microbiome; Humans; Methylamines; Mice; Mice, Inbred C57BL; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Spin Labels; Superoxides; Tyrosine; Vasodilation; Young Adult | 2020 |
Receptor tyrosine kinases-instructed release of its inhibitor from hydrogel to delay ovarian aging.
Topics: Aging; Amino Acid Sequence; Animals; Female; Humans; Hydrogels; Mice; Ovary; Peptide Fragments; Tyrosine | 2021 |
Downregulation of the tyrosine degradation pathway extends
Topics: Aging; Animals; Drosophila melanogaster; Electron Transport Chain Complex Proteins; Longevity; Mitochondria; Tigecycline; Tyrosine; Tyrosine Transaminase | 2020 |
Mitochondria exert age-divergent effects on recovery from spinal cord injury.
Topics: 2,4-Dinitrophenol; Aging; Animals; Cell Survival; Disease Progression; Female; Mice; Mice, Inbred C57BL; Mitochondria; Neurodegenerative Diseases; Neurons; Oxidative Stress; Oxygen Consumption; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries; Tyrosine; Uncoupling Agents | 2021 |
Employing metabolomic approaches to determine the influence of age on experimental autoimmune encephalomyelitis (EAE).
Topics: Age Factors; Aging; Animals; Autoimmunity; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Unsaturated; Female; Interleukin-6; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; NADPH Oxidases; Risk Factors; Sphingolipids; Spinal Cord; Tryptophan; Tyrosine | 2021 |
Sex and Age-Related Differences in Neuroinflammation and Apoptosis in
Topics: Aging; Animals; Apoptosis; Biomarkers; Caspase 3; Docosahexaenoic Acids; Ependymoglial Cells; Female; Inflammation; Male; Mice, Inbred BALB C; Microglia; NF-kappa B; Retina; Sex Characteristics; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
Impaired activity of adherens junctions contributes to endothelial dilator dysfunction in ageing rat arteries.
Topics: Acetylcholine; Adherens Junctions; Aging; Animals; Antigens, CD; Arteries; Benzodioxoles; Cadherins; Endothelial Cells; Male; Phosphorylation; Quinazolines; Rats, Inbred F344; src-Family Kinases; Tyrosine; Vasodilator Agents | 2017 |
Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Glutathione; Hippocampus; Male; Metabolome; Prefrontal Cortex; Rats, Sprague-Dawley; Sphingolipids; Tandem Mass Spectrometry; Tyrosine | 2017 |
Food for thought: association between dietary tyrosine and cognitive performance in younger and older adults.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Cognition; Cross-Sectional Studies; Dietary Supplements; Executive Function; Female; Germany; Humans; Intelligence; Male; Memory, Episodic; Memory, Short-Term; Middle Aged; Tyrosine; Young Adult | 2019 |
Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide.
Topics: Aging; Animals; Chemokine CCL2; Endoplasmic Reticulum Stress; Fibrosis; Heart; Hydrogen Sulfide; Hydroxyproline; Interleukin-6; Male; Malondialdehyde; Myocardium; Physical Conditioning, Animal; Rats; Sulfides; Tyrosine | 2018 |
Effects of estrogen and aging on synaptic morphology and distribution of phosphorylated Tyr1472 NR2B in the female rat hippocampus.
Topics: Aging; Animals; CA1 Region, Hippocampal; Dendritic Spines; Estradiol; Female; Neuronal Plasticity; Ovariectomy; Phosphorylation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tyrosine | 2019 |
The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age.
Topics: Aging; Animals; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickness; Cell Proliferation; Diet, Western; Endothelial Cells; Fatty Acids; Male; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Oxidative Stress; Regional Blood Flow; Tyrosine | 2019 |
Age-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: Particular importance for early infancy.
Topics: Adolescent; Adrenal Gland Neoplasms; Aging; Blood Chemical Analysis; Catecholamines; Child; Child, Preschool; Chromatography, Liquid; Dopamine; Female; Humans; Infant; Infant, Newborn; Male; Metanephrine; Normetanephrine; Paraganglioma; Pheochromocytoma; Reference Values; Tandem Mass Spectrometry; Tyrosine | 2019 |
The Association of Aromatic Amino Acids with Incident Hip Fracture, aBMD, and Body Composition from the Cardiovascular Health Study.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Aging; Amino Acids, Aromatic; Body Composition; Body Mass Index; Bone Density; Diet; Diet Surveys; Ethnicity; Female; Hip Fractures; Humans; Male; Multivariate Analysis; Osteoporosis; Phenylalanine; Risk; Tryptophan; Tyrosine | 2019 |
Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: consequences of treatment with antioxidant pyridoindole.
Topics: Aging; Aldehydes; Animals; Antioxidants; Cerebral Cortex; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Heart Ventricles; Indoles; Kidney; Lens, Crystalline; Liver; Male; Oxidation-Reduction; Oxidative Stress; Proteins; Pyridines; Rats; Rats, Wistar; Tyrosine | 2013 |
Mitral and tufted cells are potential cellular targets of nitration in the olfactory bulb of aged mice.
Topics: Aging; Animals; Biomarkers; Blotting, Western; Immunohistochemistry; Memory; Mice; Microscopy, Electron; Nitric Oxide; Olfactory Bulb; Oxidative Stress; Smell; Tyrosine | 2013 |
Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.
Topics: Aging; Animals; Brain; Dependovirus; Genetic Vectors; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Motor Neurons; Mutation; Neuroglia; Neurons; Promoter Regions, Genetic; Purkinje Cells; Spinal Cord; Substantia Nigra; Transduction, Genetic; Tyrosine | 2013 |
Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging.
Topics: Aging; Animals; Antioxidants; Apoptosis; Biomarkers; Blotting, Western; Brain; Flow Cytometry; Gene Expression; Glutathione; Heterozygote; Immunohistochemistry; In Situ Nick-End Labeling; Lipofuscin; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenotype; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2014 |
The senescence-accelerated mouse prone-8 (SAM-P8) oxidative stress is associated with upregulation of renal NADPH oxidase system.
Topics: Aging; Animals; Gene Expression; Glutathione; Glutathione Disulfide; Kidney; Lipid Peroxidation; Male; Malondialdehyde; Membrane Glycoproteins; Mice; Mice, Transgenic; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; Tyrosine; Up-Regulation | 2013 |
Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline.
Topics: Aging; Animals; Blotting, Western; Brain; Cognition Disorders; Diet; Disease Models, Animal; Isoelectric Focusing; Male; Mass Spectrometry; Nitrosation; Proteomics; Rats; Rats, Inbred F344; Tyrosine; Vitamin D Deficiency | 2013 |
Brain aging and testosterone-induced neuroprotection: studies on cultured sheep cortical neurons.
Topics: Aging; Animals; Cerebral Cortex; DNA Topoisomerases, Type II; DNA-Binding Proteins; Neurons; Neuroprotective Agents; Sheep; Testosterone; Tyrosine; Up-Regulation | 2013 |
[The effect of PPARalpha signal channel on atorvastatin inhibiting MMP-9 expression in aging myocytes].
Topics: Aging; Animals; Atorvastatin; Cells, Cultured; Heptanoic Acids; Matrix Metalloproteinase 9; Muscle Cells; Oxazoles; PPAR alpha; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2013 |
Aging aggravates nitrate-mediated ROS/RNS changes.
Topics: Adult; Aged; Aging; Angina, Unstable; Animals; Aorta, Thoracic; Female; Glutathione; Humans; Isosorbide Dinitrate; Male; Malondialdehyde; Middle Aged; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2014 |
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction.
Topics: Adipose Tissue; Aging; Animals; Arteries; Body Weight; Carnitine; Glutamic Acid; Malates; Male; Mice; Mitochondria; Neovascularization, Physiologic; Oxidative Stress; Oxygen Consumption; Succinic Acid; Triglycerides; Tyrosine; Vasodilation | 2014 |
Plasma levels of lysine, tyrosine, and valine during pregnancy are independent risk factors of insulin resistance and gestational diabetes.
Topics: Adult; Aging; Asian People; Blood Glucose; Blood Pressure; Diabetes, Gestational; Diet; Energy Intake; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Lysine; Pregnancy; Risk Factors; Tyrosine; Valine | 2015 |
Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide.
Topics: Aging; Animals; Blotting, Western; Cells, Cultured; Cytosol; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitochondria; Mitochondria, Muscle; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide; Peroxiredoxins; Peroxynitrous Acid; Superoxides; Tyrosine | 2015 |
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.
Topics: Activin Receptors, Type I; Aging; Animals; Cartilage, Articular; Collagen Type II; Computer Simulation; Extracellular Matrix; Immunohistochemistry; Interleukin-1; Knee Joint; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Oxidative Stress; Signal Transduction; Transforming Growth Factor beta; Tyrosine | 2016 |
Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Topics: Aging; Animals; Arginase; Cell Hypoxia; Enzyme Activation; Hypertension; Lung; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Pulmonary Artery; Rats, Sprague-Dawley; Tyrosine | 2015 |
Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus.
Topics: Aging; Animals; Fasting; Hippocampus; Lipopolysaccharides; Male; Neurodegenerative Diseases; Neurogenic Inflammation; Nitric Oxide; Nitric Oxide Synthase; Nucleotides, Cyclic; Oxidative Stress; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thiobarbiturates; Tyrosine | 2015 |
Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells.
Topics: Aging; Animals; Cells, Cultured; Humans; Leydig Cells; Male; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Testosterone; Tyrosine | 2015 |
Resveratrol Rescues Kidney Mitochondrial Function Following Hemorrhagic Shock.
Topics: Acute Kidney Injury; Aging; Aldehydes; Animals; Antioxidants; Citrate (si)-Synthase; Hemorrhage; Kidney; Male; Mitochondria; Oxidative Stress; Rats; Rats, Long-Evans; Reactive Oxygen Species; Resuscitation; Resveratrol; Shock, Hemorrhagic; Stilbenes; Tyrosine | 2015 |
Treadmill Exercise Attenuates Retinal Oxidative Stress in Naturally-Aged Mice: An Immunohistochemical Study.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Deoxyguanosine; Lysine; Male; Mice; Oxidative Stress; Physical Conditioning, Animal; Retina; Tyrosine | 2015 |
l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation.
Topics: Aging; Albinism, Oculocutaneous; Animals; Cell Differentiation; Cell Proliferation; Intramolecular Oxidoreductases; Melanocytes; Membrane Glycoproteins; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Primary Cell Culture; RNA, Messenger; Tyrosine; Up-Regulation | 2015 |
Hearing impairment, cochlear morphology, and peroxynitrite (ONOO(-)) formation in adult and aging NOS II knockout mice.
Topics: Aging; Animals; Cochlea; Female; Hearing Loss; Immunohistochemistry; Mice, Knockout; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Tyrosine | 2016 |
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aorta, Thoracic; Blotting, Western; Collagen Type IV; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Fibronectins; Immunohistochemistry; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin; Renin-Angiotensin System; Superoxide Dismutase; Transforming Growth Factor beta; Tyrosine | 2016 |
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Hippocampus; Mice, Transgenic; Microelectrodes; Mitochondria; Neurotransmitter Agents; Nitric Oxide; Oxidative Phosphorylation; Oxygen Consumption; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tyrosine | 2016 |
Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice.
Topics: Abietanes; Aging; Aldehydes; Analysis of Variance; Animals; Cinnamates; Conditioning, Classical; Conditioning, Operant; Depsides; Dose-Response Relationship, Drug; Electroshock; Maze Learning; Mice; Mice, Mutant Strains; Oxidative Stress; Recognition, Psychology; Reinforcement, Psychology; Rosmarinic Acid; Rosmarinus; Triglycerides; Tyrosine | 2016 |
Response of the Nitric Oxide System to Hypobaric Hypoxia in the Aged Striatum.
Topics: Aging; Animals; Atmospheric Pressure; Corpus Striatum; Hypoxia, Brain; Immunohistochemistry; Male; Models, Neurological; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2017 |
Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration.
Topics: Aging; Animals; Cytosol; Dopamine Plasma Membrane Transport Proteins; Fluorescent Antibody Technique; Immunohistochemistry; Macaca mulatta; Nerve Degeneration; Neurons; Substantia Nigra; Tyrosine; Ventral Tegmental Area; Vesicular Monoamine Transport Proteins | 2008 |
Oxidative alternations in rat heart homogenate and mitochondria during ageing.
Topics: Aging; Anilino Naphthalenesulfonates; Animals; Electron Transport Complex IV; Fluorescent Dyes; Lipid Peroxidation; Lysine; Male; Mitochondria, Heart; Myocardium; Oxidation-Reduction; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tryptophan; Tyrosine | 2008 |
Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.
Topics: Age Factors; Aging; Aldehydes; Animals; Carbonic Anhydrase III; Hindlimb Suspension; LIM Domain Proteins; Male; Muscle Proteins; Muscle, Skeletal; Oxidation-Reduction; Proteomics; Rats; Rats, Inbred F344; Time Factors; Tyrosine | 2008 |
Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading.
Topics: Aging; Animals; Blotting, Western; Catalase; Female; Hindlimb Suspension; Hydrogen Peroxide; Male; Malondialdehyde; Muscle, Skeletal; Organ Size; Oxidative Stress; Rats; Rats, Inbred BN; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Tyrosine | 2008 |
Effect of nitric oxide on auditory cortical neurons of aged rats.
Topics: Age Factors; Aging; Animals; Auditory Cortex; In Vitro Techniques; Male; Membrane Potentials; NADP; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
Inflammatory and redox status of ponies with a history of pasture-associated laminitis.
Topics: Aging; Animal Husbandry; Animals; Cytokines; Female; Foot Diseases; Hoof and Claw; Horse Diseases; Horses; Inflammation; Oxidation-Reduction; Risk Factors; Superoxide Dismutase; Tyrosine | 2009 |
B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging.
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Carotid Arteries; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Femoral Artery; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Superoxides; Tyrosine; Vascular Resistance; Vasodilation; Vasodilator Agents | 2009 |
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production.
Topics: Aging; Amino Acid Sequence; Animals; Brain; Coenzyme A-Transferases; Cytochromes c; Energy Metabolism; Male; Mitochondria; Mitochondrial Proteins; Mitochondrial Proton-Translocating ATPases; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Reactive Nitrogen Species; Tandem Mass Spectrometry; Tyrosine | 2009 |
Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice.
Topics: Aging; Air; Animals; Animals, Newborn; Body Weight; Bronchoalveolar Lavage Fluid; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Epithelial Cells; Gene Deletion; Hyperoxia; Mice; NADPH Oxidases; Oxygen; Pneumonia; Protein Transport; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein C; Survival Analysis; Tyrosine | 2009 |
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.
Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascular; In Vitro Techniques; Male; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Exertion; Superoxide Dismutase; Tyrosine; Vasodilation | 2009 |
Age-related changes in the insulin receptor β in the gerbil hippocampus.
Topics: Aging; Animals; Dentate Gyrus; Gerbillinae; Hippocampus; Immunohistochemistry; Male; Memory Disorders; Mossy Fibers, Hippocampal; Phosphorylation; Receptor, Insulin; Tyrosine | 2009 |
Aging impairs flow-induced dilation in coronary arterioles: role of NO and H(2)O(2).
Topics: Aging; Animals; Antioxidants; Arterioles; Catalase; Coronary Circulation; Cyclic N-Oxides; Deferoxamine; Hydrogen Peroxide; Male; Microscopy, Fluorescence; Nitric Oxide; Rats; Rats, Inbred F344; Reactive Oxygen Species; RNA, Messenger; Siderophores; Spin Labels; Superoxide Dismutase; Tyrosine; Vasodilation | 2009 |
Run for your life: exercise, oxidative stress and the ageing endothelium.
Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascular; Male; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Exertion; Superoxide Dismutase; Tyrosine; Vasodilation | 2009 |
eNOS uncoupling and endothelial dysfunction in aged vessels.
Topics: Acetylcholine; Age Factors; Aging; Alcohol Oxidoreductases; Animals; Biopterins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Enzyme Stability; GTP Cyclohydrolase; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Multimerization; Pterins; Superoxides; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2009 |
Regulation of membrane band 3 Tyr-phosphorylation by proteolysis of p72(Syk) and possible involvement in senescence process.
Topics: Aging; Anion Exchange Protein 1, Erythrocyte; Erythrocyte Membrane; Erythrocytes; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Peptide Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Syk Kinase; Tyrosine | 2009 |
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Humans; Neurons; Parkinson Disease; Phosphorylation; Serine; Tyrosine | 2009 |
Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.
Topics: Aging; Aldehydes; Animals; Calcium Channels; Ear, Inner; Glucuronidase; Klotho Proteins; Mice; Mice, Inbred CBA; Microscopy; Superoxide Dismutase; TRPV Cation Channels; Tyrosine | 2009 |
Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance.
Topics: Aging; Animals; Diet; Dietary Fats; Eating; Energy Metabolism; Female; Gene Knock-In Techniques; Humans; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuropeptides; Obesity; Receptors, Leptin; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Tyrosine | 2010 |
Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Bruch Membrane; Chromatography, High Pressure Liquid; Humans; Lipofuscin; Mass Spectrometry; Middle Aged; Nitrosation; Pyridinium Compounds; Retinoids; Tyrosine | 2010 |
Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging.
Topics: Adenosine Triphosphate; Age Factors; Aging; Analysis of Variance; Animals; Binding Sites; Blotting, Western; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Immunoprecipitation; Liver; Male; Mitochondria; Mitochondrial Proton-Translocating ATPases; Nitrates; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2010 |
Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction.
Topics: Adrenergic Uptake Inhibitors; Aged; Aging; Biopterins; Dose-Response Relationship, Drug; Female; Humans; Male; Norepinephrine; Oxidative Stress; Regional Blood Flow; Skin; Tyramine; Tyrosine; Vasoconstriction; Young Adult | 2010 |
Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle.
Topics: Aging; Animals; Creatine Kinase; Glycogen Phosphorylase; Kinetics; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Oxidative Stress; Protein Carbonylation; Tyrosine | 2009 |
Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle.
Topics: Adaptation, Physiological; Age Factors; Aging; Animals; Blotting, Western; Calcium; Exercise Test; HSP70 Heat-Shock Proteins; Male; Muscle, Skeletal; Oxidative Stress; Physical Conditioning, Animal; Physical Endurance; Protein Carbonylation; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2010 |
Age-related changes in nitric oxide synthase in the lateral geniculate nucleus of rats.
Topics: Aging; Animals; Geniculate Bodies; Immunohistochemistry; Male; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase Type I; Rats; Rats, Inbred F344; Tyrosine | 2010 |
Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Weight; Cytokines; Gene Deletion; Glucose Clamp Technique; Hyperinsulinism; Inflammation; Insulin Resistance; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nitric Oxide Synthase Type II; Oxygen Consumption; Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults.
Topics: Aged; Aged, 80 and over; Aging; Brain Mapping; Corpus Striatum; Dopamine; Fluorine Radioisotopes; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Memory, Short-Term; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Tyrosine; Young Adult | 2011 |
Pulmonary exposure to carbon black nanoparticles and vascular effects.
Topics: Administration, Inhalation; Aging; Animals; Apolipoproteins E; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Heme Oxygenase-1; In Vitro Techniques; Intercellular Adhesion Molecule-1; Lung; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Nanoparticles; Oxidative Stress; Plaque, Atherosclerotic; Pneumonia; Soot; Time Factors; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2010 |
The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation.
Topics: Aging; Animals; Blotting, Western; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Endotoxemia; Extracellular Space; Inflammation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Tyrosine | 2011 |
Proteins containing oxidized amino acids induce apoptosis in human monocytes.
Topics: Aging; Annexin A5; Apoptosis; Caspase 3; Cell Line; Ceroid; DNA Fragmentation; Enzyme Activation; Humans; Intracellular Membranes; Levodopa; Lipofuscin; Lysosomes; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Monocytes; Oxidation-Reduction; Permeability; Protein Biosynthesis; Tyrosine | 2011 |
Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Cytokines; Endothelium, Vascular; Forkhead Box Protein O3; Forkhead Transcription Factors; I-kappa B Kinase; Male; Mice; NADPH Oxidases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; Salicylates; Superoxide Dismutase; Tyrosine; Vasodilation | 2011 |
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.
Topics: Aging; Animals; Blotting, Western; Carbonic Anhydrase III; Electric Stimulation; Ethidium; Fluoresceins; Fluorescence; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxiredoxins; Peroxynitrous Acid; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Tyrosine | 2011 |
The lumbrical muscle: a novel in situ system to evaluate adult skeletal muscle proteolysis and anticatabolic drugs for therapeutic purposes.
Topics: Adrenergic beta-2 Receptor Agonists; Aging; Animals; Cyclic AMP; Drug Evaluation, Preclinical; In Vitro Techniques; Male; Muscle Denervation; Muscle Proteins; Muscle, Skeletal; Proteolysis; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2011 |
Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress.
Topics: Adult; Aging; Brachial Artery; Cardiovascular Diseases; Endothelial Cells; Endothelium, Vascular; Exercise; Gene Expression; Humans; Male; Middle Aged; NADPH Oxidases; Oxidative Stress; Oxygen Consumption; Risk Factors; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Vasodilation | 2011 |
Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat.
Topics: Aging; Animals; Aorta; Chronic Disease; Hydrogen Peroxide; Kidney; Kidney Diseases; Male; NADPH Oxidases; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Superoxide Dismutase; Tyrosine | 2011 |
Ishemia-reperfusion enhances GAPDH nitration in aging skeletal muscle.
Topics: Aging; Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Mass Spectrometry; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nitrates; Reperfusion Injury; RNA, Messenger; Tyrosine | 2011 |
Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats.
Topics: Age Factors; Aging; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Immunoprecipitation; Male; Maze Learning; Nerve Growth Factor; Nerve Growth Factors; Plasminogen; Protein Precursors; Rats; Rats, Inbred F344; Reaction Time; Tissue Plasminogen Activator; Tyrosine | 2012 |
Cumulative 3-nitrotyrosine in specific muscle proteins is associated with muscle loss during aging.
Topics: Aging; Animals; Biomarkers; Body Weight; Energy Intake; Hindlimb; Mitochondria, Muscle; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Myofibrils; Organ Size; Protein Carbonylation; Quadriceps Muscle; Rats; Rats, Wistar; Sarcopenia; Tyrosine | 2012 |
A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging.
Topics: Aging; Animals; Brain; Cognition; Dietary Supplements; Growth Hormone; Mice; Mice, Transgenic; Mitochondria; Stress, Physiological; Tyrosine | 2012 |
Evidence of increased oxidative stress in aged mesenteric lymphatic vessels.
Topics: Age Factors; Aging; Animals; Blotting, Western; Immunohistochemistry; Lipid Peroxidation; Lymphatic Vessels; Male; Mesentery; Mitochondria; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Thiobarbituric Acid Reactive Substances; Tyrosine | 2012 |
Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.
Topics: Aging; Animals; Antioxidants; Aorta; Collagen Type I; Drug Evaluation, Preclinical; Elasticity; Elastin; Glycation End Products, Advanced; Male; Mice; Oxidative Stress; Pyrogallol; Sodium Nitrite; Superoxides; Tissue Culture Techniques; Transforming Growth Factor beta; Tyrosine; Vascular Stiffness | 2012 |
Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization.
Topics: Age Factors; Aging; Animals; Blood Flow Velocity; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Hindlimb; Ischemia; Laser-Doppler Flowmetry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; NADPH Oxidase 2; NADPH Oxidases; Neovascularization, Physiologic; Oxidative Stress; Recovery of Function; Regional Blood Flow; Stem Cells; Superoxides; Time Factors; Tyrosine; Vascular Diseases | 2012 |
Altered neuronal nitric oxide synthase in the aging vascular system: implications for estrogens therapy.
Topics: Aging; Animals; Aorta, Thoracic; Arginine; Blotting, Western; Estradiol; Female; In Vitro Techniques; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Ovariectomy; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine | 2012 |
Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.
Topics: Aging; Amino Acid Motifs; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain; Cognition; Gene Expression Regulation; Gene Knock-In Techniques; Glycine; Mice; Mice, Transgenic; Motor Activity; Motor Endplate; Protein Structure, Tertiary; Receptor, trkA; Signal Transduction; Synapses; Tyrosine | 2012 |
Curcumin ameliorates arterial dysfunction and oxidative stress with aging.
Topics: Age Factors; Aging; Animals; Antioxidants; Aorta; Carotid Arteries; Collagen Type I; Curcumin; Dose-Response Relationship, Drug; Elastin; Endothelium, Vascular; Glycation End Products, Advanced; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pulse Wave Analysis; Superoxide Dismutase; Superoxides; Tyrosine; Vascular Stiffness; Vasodilation; Vasodilator Agents | 2013 |
Differential hepatic protein tyrosine nitration of mouse due to aging - effect on mitochondrial energy metabolism, quality control machinery of the endoplasmic reticulum and metabolism of drugs.
Topics: Aging; Animals; Endoplasmic Reticulum; Energy Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Pharmaceutical Preparations; Proteins; Reactive Nitrogen Species; Tyrosine; Xenobiotics | 2013 |
Chronic Tempol treatment restores pharmacological preconditioning in the senescent rat heart.
Topics: Aging; Animals; Antioxidants; Calcium; Cardiotonic Agents; Cyclic N-Oxides; Heart; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Inbred F344; Spin Labels; Superoxide Dismutase; Tyrosine | 2013 |
Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade.
Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Hypertension, Renal; Immunoenzyme Techniques; Kidney Failure, Chronic; Kidney Glomerulus; Losartan; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Tyrosine | 2002 |
Immunohistochemical study on the distribution of nitrotyrosine and neuronal nitric oxide synthase in aged rat cerebellum.
Topics: Aging; Animals; Cerebellar Cortex; Cerebellum; Image Processing, Computer-Assisted; Immunohistochemistry; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Purkinje Cells; Rats; Rats, Sprague-Dawley; Tyrosine; Up-Regulation | 2002 |
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
Topics: Aging; Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Drug Resistance; Humans; Insulin-Like Growth Factor I; Interleukin-1; Macaca fascicularis; Osteoarthritis; Oxidation-Reduction; Tyrosine | 2002 |
Proteasome function and protein oxidation in the aged retina.
Topics: Aging; Aldehydes; Animals; Blotting, Western; Caseins; Chymotrypsin; Cysteine Endopeptidases; Eye Proteins; Male; Multienzyme Complexes; Oxidation-Reduction; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred BN; Rats, Inbred F344; Retina; Tyrosine | 2002 |
Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Body Weight; Cerebral Cortex; Down-Regulation; Encephalitis; Exploratory Behavior; Male; Melatonin; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; RNA, Messenger; Tyrosine | 2002 |
Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats.
Topics: Adenoviridae; Aging; Animals; beta-Galactosidase; Cell Line; Cyclic GMP; Genetic Vectors; Humans; Male; Microscopy, Confocal; Penile Erection; Penis; Rats; Rats, Inbred BN; Recombinant Fusion Proteins; RNA, Messenger; Superoxide Dismutase; Superoxides; Transfection; Tyrosine | 2003 |
Relation of aging with oxidative protein damage parameters in the rat skeletal muscle.
Topics: Aging; Animals; Carbon; Lipid Peroxidation; Lipid Peroxides; Male; Muscle, Skeletal; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Sulfhydryl Compounds; Time Factors; Tyrosine | 2003 |
Changes in ultrastructural characteristics of endolymphatic sac ribosome-rich cells of the rat during development.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Embryonic and Fetal Development; Endolymphatic Sac; Fucose; Microscopy, Electron; Organelles; Rats; Rats, Wistar; Ribosomes; Tyrosine | 2003 |
Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats.
Topics: Adipose Tissue; Aging; Animals; Animals, Newborn; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Sodium Glutamate; Tyrosine | 2003 |
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates; Glycine; Guinea Pigs; Histidine; Leucine; Lysine; Nerve Tissue Proteins; Nervous System; Phenylalanine; Research; Serine; Spinal Cord; Threonine; Tyrosine; Valine | 1964 |
THE DEVELOPMENT OF PIGMENTATION AND ENZYME ACTIVITY IN THE NUCLEUS SUBSTANTIAE NIGRAE OF THE CAT.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Animals, Newborn; Autoradiography; Brain; Carbon Isotopes; Catecholamines; Cats; Pigmentation; Research; Substantia Nigra; Tyrosine | 1965 |
STRUCTURE OF COLLAGEN FROM HUMAN TENDON AS INFLUENCED BY AGE AND SEX.
Topics: Adolescent; Aging; Child; Collagen; Fluorescence; Histocytochemistry; Humans; Infant; Nitrogen; Protein Hydrolysates; Sex; Spectrophotometry; Tendons; Tyrosine | 1965 |
THE ENZYMATIC BASIS OF TYROSYLURIA IN RATS FED TYROSINE.
Topics: Aging; Amino Acids; Diet; Hydrolases; Liver; Phenylketonurias; Rats; Research; Tyrosine; Tyrosine Transaminase | 1964 |
THE CLEAVAGE OF TYROSYL PEPTIDES BY PEPSIN FROM COLLAGEN SOLUBILISED BY THE NISHIHARA TECHNIQUE.
Topics: Aging; Biochemical Phenomena; Biochemistry; Chromatography; Collagen; Electrophoresis; Gelatin; Pepsin A; Peptides; Protein Denaturation; Tendons; Tyrosine | 1965 |
Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosis.
Topics: Aging; Animals; Apoptosis; B-Lymphocytes; Cell Division; Immunophenotyping; Interleukin-7; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Knockout; Phosphorylation; Tyrosine | 2003 |
Altered regulation of Fc gamma RII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation.
Topics: Aging; Amino Acid Motifs; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; B-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Cellular Senescence; Dendritic Cells, Follicular; Down-Regulation; Germinal Center; Kinetics; Lymph Nodes; Lymphocyte Activation; Lymphocyte Count; Mice; Mice, Inbred BALB C; Mice, Knockout; Peanut Agglutinin; Pertussis Vaccine; Receptors, Complement 3b; Receptors, Complement 3d; Receptors, IgG; Signal Transduction; Tyrosine | 2003 |
Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat.
Topics: Aging; Animals; Body Weight; Cardiotonic Agents; Estrogens; Ethylenediamines; Female; Heart; Heart Ventricles; Myocardial Ischemia; Myocardial Reperfusion Injury; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Size; Organometallic Compounds; Ovariectomy; Rats; Rats, Sprague-Dawley; Recovery of Function; Superoxide Dismutase; Tyrosine; Uterus | 2004 |
Tyrosine phosphorylation-dependent activation of NFkappaB is compromised in T cells from the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Enzyme Inhibitors; Humans; Hydrogen Peroxide; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Tyrosine Phosphatases; T-Lymphocytes; Tyrosine; Vanadates | 2004 |
Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat.
Topics: Aging; Animals; Caloric Restriction; Insulin; Lipid Metabolism; Liver; Male; Muscle, Skeletal; Mutation; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor, Insulin; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Tyrosine; Up-Regulation | 2004 |
Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Biomarkers; Brain; Cells, Cultured; Disease Models, Animal; Down-Regulation; Glutamate-Ammonia Ligase; Lipid Peroxidation; Memory Disorders; Mice; Mice, Inbred Strains; Neurons; Oligonucleotides, Antisense; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Tyrosine | 2004 |
Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging.
Topics: Aging; Animals; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Myocardium; Nanotechnology; Proteins; Proteomics; Rats; Rats, Inbred BN; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Beta2-agonist administration increases sarcoplasmic reticulum Ca2+-ATPase activity in aged rat skeletal muscle.
Topics: Adrenergic beta-Agonists; Aging; Animals; Blotting, Western; Calcium; Calcium-Transporting ATPases; Cell Fractionation; Fenoterol; Kinetics; Male; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Relaxation; Muscle, Skeletal; Myosin Heavy Chains; Protein Isoforms; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrometry, Fluorescence; Tyrosine | 2005 |
Deletion of p66shc gene protects against age-related endothelial dysfunction.
Topics: Adaptor Proteins, Signal Transducing; Aging; Animals; Aorta; Endothelium, Vascular; Isometric Contraction; Longevity; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Proteins; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Superoxide Dismutase; Tyrosine; Vasoconstriction | 2004 |
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.
Topics: Aging; Animals; Apoptosis; Apoptosis Inducing Factor; Autophagy; Brain Injuries; Calpain; Caspase 3; Caspases; Cell Death; Cytochromes c; Disease Models, Animal; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondria; Necrosis; Neurons; Protein Transport; Tyrosine | 2005 |
Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling.
Topics: Adipose Tissue; Aging; Animals; Area Under Curve; Enzyme-Linked Immunosorbent Assay; Female; Glucose; Growth Hormone; Humans; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Janus Kinase 2; Lipid Metabolism; Liver; Muscles; Obesity; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Time Factors; Tyrosine | 2005 |
Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction.
Topics: Aging; Animals; Caloric Restriction; Diet; Energy Intake; Inflammation; Kidney; Lipopolysaccharides; Male; Oxidation-Reduction; Oxidative Stress; Peroxidase; Rats; Rats, Inbred F344; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2005 |
Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry.
Topics: Aging; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Molecular Sequence Data; Muscle Proteins; Muscle, Skeletal; Nanotechnology; Nitrates; Proteome; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential.
Topics: Aging; Animals; Autoantigens; CD8 Antigens; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Proliferation; Clonal Deletion; Cyclin-Dependent Kinase Inhibitor p21; Female; H-Y Antigen; Immunophenotyping; Intestinal Mucosa; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Weight; Phosphorylation; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocyte Subsets; Thymus Gland; Tyrosine | 2005 |
Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Female; Genotype; Histidine; Humans; Male; Memory; Middle Aged; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2A; Statistics as Topic; Time Factors; Tyrosine | 2005 |
Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.
Topics: Aging; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Female; Humans; Inclusion Bodies; Male; Mice; Mice, Transgenic; Mutation, Missense; Nerve Degeneration; Neurons; Phosphorylation; Protein Isoforms; tau Proteins; Tauopathies; Tyrosine; Up-Regulation | 2005 |
Hepatocellular carcinoma and the penetrance of HFE C282Y mutations: a cross sectional study.
Topics: Aging; Carcinoma, Hepatocellular; Case-Control Studies; Cross-Sectional Studies; Cysteine; Female; Genetic Predisposition to Disease; Genotype; Hemochromatosis Protein; Histocompatibility Antigens Class I; Homozygote; Humans; Liver Neoplasms; Male; Membrane Proteins; Middle Aged; Mutation; Penetrance; Tyrosine | 2005 |
Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging.
Topics: Aging; Animals; Blotting, Western; Brain; Caveolin 1; Caveolins; Chromatography, High Pressure Liquid; Immunoprecipitation; Mass Spectrometry; Membrane Proteins; Rats; Rats, Inbred BN; Rats, Inbred F344; Tubulin; Tyrosine | 2005 |
Neonatal cerebral hypoxia-ischemia: involvement of FAK-dependent pathway.
Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Crk-Associated Substrate Protein; Focal Adhesion Kinase 1; Hypoxia, Brain; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; src-Family Kinases; Tyrosine | 2005 |
Tau is hyperphosphorylated in the insulin-like growth factor-I null brain.
Topics: Aging; Animals; Brain; Drug Residues; Insulin-Like Growth Factor I; Lipofuscin; Male; Mice; Mice, Knockout; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; tau Proteins; Tyrosine | 2005 |
3-Nitrotyrosine modification of SERCA2a in the aging heart: a distinct signature of the cellular redox environment.
Topics: Adenosine Triphosphate; Age Factors; Aging; Animals; Calcium-Transporting ATPases; Cell Respiration; Heart; Male; Muscle, Skeletal; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stress, Physiological; Tyrosine | 2005 |
Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
Topics: Acetone; Administration, Oral; Aging; Animals; Blotting, Western; Body Weight; Dichloroacetic Acid; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Glutathione Transferase; Humans; Liver; Male; Maleates; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
Topics: Aging; Animals; Calcium-Transporting ATPases; Cardiovascular Diseases; Dithionite; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Kidney; Oxidative Stress; Peroxynitrous Acid; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Tyrosine | 2006 |
Expression and activity patterns of nitric oxide synthases and antioxidant enzymes reveal a substantial heterogeneity between cardiac and vascular aging in the rat.
Topics: Aging; Animals; Femoral Artery; Glutathione; Heart; In Vitro Techniques; Isoenzymes; Male; Myocardial Stunning; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perfusion; Rats; Rats, Inbred F344; Renal Artery; Superoxide Dismutase; Tyrosine | 2005 |
Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.
Topics: Adult; Age Factors; Aged; Aging; Apoptosis; Chemotaxis, Leukocyte; Down-Regulation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunity, Cellular; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Neutrophils; Phosphorylation; Protein Phosphatase 1; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Reactive Oxygen Species; Serine; src-Family Kinases; Tyrosine | 2006 |
Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress.
Topics: Aconitate Hydratase; Aging; Animals; Apoptosis; Calcium; Cytochromes c; Diastole; Gene Expression Regulation; Heart Ventricles; Metallothionein; Mice; Mice, Transgenic; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; Pyrogallol; rhoA GTP-Binding Protein; Superoxides; Tyrosine | 2006 |
Age-associated tyrosine nitration of rat skeletal muscle glycogen phosphorylase b: characterization by HPLC-nanoelectrospray-tandem mass spectrometry.
Topics: Aging; Animals; Base Sequence; Chromatography, High Pressure Liquid; Glycogen Phosphorylase, Muscle Form; Longevity; Molecular Sequence Data; Muscle, Skeletal; Peroxynitrous Acid; Rats; Rats, Inbred BN; Rats, Inbred F344; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2006 |
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Cortex; Disease Models, Animal; Homozygote; Mice; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Oxidative Stress; Respiration; Superoxide Dismutase; Tyrosine | 2006 |
Function of the rat carotid body chemoreceptors in ageing.
Topics: Acidosis; Aging; Animals; Carotid Body; Catecholamines; Catechols; Chemoreceptor Cells; Female; Hypercapnia; Hypoxia; Male; Potassium; Rats; Rats, Sprague-Dawley; Seasons; Tyrosine; Tyrosine 3-Monooxygenase | 2006 |
Protein nitration with aging in the rat semimembranosus and soleus muscles.
Topics: Aging; Animals; Male; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Inbred F344; Tyrosine | 2006 |
Oxidative imbalance in the aging inner ear.
Topics: Aging; Aldehydes; Animals; Apoptosis Inducing Factor; Biomarkers; Cochlea; Free Radicals; Hair Cells, Auditory; Male; Mice; Mice, Inbred CBA; Nerve Degeneration; Neurons, Afferent; Organ of Corti; Oxidative Stress; Spiral Ganglion; Superoxide Dismutase; Tyrosine | 2007 |
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
Topics: Aging; Animals; Animals, Newborn; Cell Line, Transformed; Down-Regulation; Gene Expression; Gene Expression Profiling; Gene Transfer Techniques; Gluconeogenesis; Hepatocytes; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrosine; Up-Regulation | 2007 |
The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction.
Topics: Acetylcholine; Aging; Animals; Aorta; Diastole; Endothelium, Vascular; Heart Diseases; In Vitro Techniques; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Tyrosine; Vasodilation; Ventricular Function, Left | 2007 |
Astrocytes aged in vitro show a decreased neuroprotective capacity.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Heme Oxygenase-1; Hydrogen Peroxide; Nerve Growth Factors; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Reactive Oxygen Species; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2007 |
Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging.
Topics: Aging; Amino Acid Sequence; Animals; Blotting, Western; Cerebellum; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Proteins; Proteomics; Rats; Rats, Inbred F344; Tyrosine | 2007 |
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
Topics: Aging; Anticoagulants; Apoptosis; Binding Sites; Complement Factor H; Glycosaminoglycans; Heparin; Histidine; Humans; Macular Degeneration; Polymorphism, Single Nucleotide; Protein Structure, Quaternary; Protein Structure, Tertiary; Surface Plasmon Resonance; Tyrosine | 2007 |
Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction.
Topics: Acetylcholine; Aging; Animals; Enzyme Inhibitors; Heart; Immunohistochemistry; Indoles; Models, Animal; Myocardium; Phenylephrine; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Tyrosine | 2007 |
Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration.
Topics: Aged, 80 and over; Aging; Amino Acid Substitution; Animals; Cell Line; Cells, Cultured; Complement C3b Inactivator Proteins; Complement Factor H; Female; Histidine; Humans; Macular Degeneration; Protein Isoforms; Spodoptera; Tyrosine | 2007 |
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.
Topics: Adolescent; Adult; Aged; Aging; Brachial Artery; Catalase; Endothelial Cells; Fluorescent Antibody Technique; Humans; Male; Middle Aged; NADPH Oxidases; Oxidative Stress; Reference Values; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Up-Regulation; Vasodilation; Veins; Xanthine Oxidase | 2007 |
Developmental changes in the association of NMDA receptors with lipid rafts.
Topics: Aging; Animals; Cholesterol; Disks Large Homolog 4 Protein; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Membrane Proteins; Nerve Tissue Proteins; Neuropeptides; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2007 |
Age modulates the nitric oxide system response in the ischemic cerebellum.
Topics: Aging; Animals; Astrocytes; Brain Ischemia; Cerebellar Diseases; Cerebellum; Down-Regulation; Glial Fibrillary Acidic Protein; Gliosis; Isoenzymes; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Reperfusion Injury; Time Factors; Tyrosine; Up-Regulation | 2007 |
Abnormal processing of tau in the brain of aged TgCRND8 mice.
Topics: Aging; Animals; Brain; Female; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Inclusion Bodies; Male; MAP Kinase Kinase 4; Mice; Mice, Transgenic; Phosphorylation; Plaque, Amyloid; tau Proteins; Tyrosine | 2007 |
Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat.
Topics: Aging; Aldehydes; Analysis of Variance; Animals; Blood Pressure; Female; Heart; Heat-Shock Proteins; Immunoblotting; Immunohistochemistry; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred BN; Rats, Inbred F344; Reactive Oxygen Species; Regression Analysis; Signal Transduction; Superoxides; Tyrosine | 2007 |
Gender difference as regards myocardial protein oxidation in aged rats: male rats have increased oxidative protein damage.
Topics: Aging; Animals; Female; Glutathione; Iron; Lipid Peroxidation; Longevity; Male; Malondialdehyde; Myocardium; Oxidation-Reduction; Oxidative Stress; Peroxides; Protein Carbonylation; Proteins; Rats; Rats, Sprague-Dawley; Sex Factors; Sulfhydryl Compounds; Tyrosine | 2007 |
Plantaris muscle of aged rats demonstrates iron accumulation and altered expression of iron regulation proteins.
Topics: Age Factors; Aging; Animals; Apoferritins; Carrier Proteins; Cation Transport Proteins; Iron; Iron Regulatory Protein 1; Lipid Peroxides; Male; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Inbred F344; Receptors, Transferrin; Tyrosine; Up-Regulation | 2008 |
Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antipsychotic Agents; Anxiety; Brain; Dibenzothiazepines; Disease Models, Animal; Female; Male; Memory Disorders; Mice; Mice, Transgenic; Plaque, Amyloid; Presenilin-1; Protease Nexins; Proto-Oncogene Proteins c-bcl-2; Quetiapine Fumarate; Receptors, Cell Surface; Tyrosine | 2009 |
The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Fertility; Hydrolases; Intestines; Mutation; Oxidative Stress; Phenotype; Protein Folding; RNA Interference; Tyrosine; Tyrosinemias | 2008 |
Effects of ubiquitin-proteasome system deregulation on the vascular senescence and atherosclerosis process in elderly patients.
Topics: Aged; Aging; Atherosclerosis; Collagen; Cyclin-Dependent Kinase Inhibitor p16; Disease Progression; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Matrix Metalloproteinase 9; Middle Aged; Proteasome Endopeptidase Complex; Tyrosine; Ubiquitin | 2008 |
Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress.
Topics: Aging; Aldehydes; Animals; Autophagy; Energy Metabolism; Heating; Hepatocytes; Immunohistochemistry; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Mitochondria; Oxidative Stress; Peroxisomes; Proteins; Rats; Rats, Inbred F344; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2008 |
[Protein synthesis and the regulation process in the cell].
Topics: Aging; Animals; Arginine; Autoradiography; Axons; Body Weight; Cell Biology; Cytoplasmic Granules; Glycine; Golgi Apparatus; Guinea Pigs; Hippocampus; Homeostasis; Leucine; Methionine; Mice; Microscopy, Electron; Neurons; Pancreas; Photoreceptor Cells; Protein Biosynthesis; Purkinje Cells; Pyramidal Tracts; Rats; Ribosomes; RNA; RNA, Messenger; Spectrophotometry; Thyroid Gland; Time Factors; Tritium; Tyrosine | 1966 |
Variations in the protein components of human intervertebral disk with age.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Collagen; Humans; Hydroxyproline; Intervertebral Disc; Middle Aged; Nitrogen; Proteins; Statistics as Topic; Tyrosine | 1967 |
Influence of chronic inorganic lead exposure on regional dopamine and 5-hydroxytryptamine turnover in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Dopamine; Erythrocytes; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Lead; Lead Poisoning; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Pregnancy; Protoporphyrins; Rats; Serotonin; Tyrosine | 1984 |
Managanese-induced biochemical changes in growing versus adult rats.
Topics: Aging; Animals; Biogenic Amines; Body Weight; Brain Chemistry; Liver; Male; Manganese; Metals; Neurotransmitter Agents; Rats; Tryptophan; Tyrosine | 1980 |
Regulation of hepatic tyrosine aminotransferase in genetically obese rats.
Topics: Adrenalectomy; Aging; Amino Acids; Animals; Corticosterone; Diet; Disease Models, Animal; Enzyme Activation; Insulin; Liver; Obesity; Rats; Tryptophan; Tyrosine; Tyrosine Transaminase | 1983 |
Effect of catecholamine precursors on stress-induced changes in motor activity, exploration, and brain monoamines in young and aged mice.
Topics: Aging; Animals; Body Temperature Regulation; Brain; Corticosterone; Dopamine; Exploratory Behavior; Male; Mice; Motor Activity; Neurotransmitter Agents; Norepinephrine; Serotonin; Stress, Physiological; Tyrosine | 1984 |
The receptor-mediated activation of tyrosine hydroxylation in the superior cervical ganglion of the rat.
Topics: Aging; Animals; Bucladesine; Carbachol; Dopamine; Ganglia, Spinal; Hydroxylation; Kinetics; Pterins; Rats; Reserpine; Tyrosine | 1981 |
In vitro energy costs of Na+, K+ATPase activity and protein synthesis in muscle from calves differing in age and breed.
Topics: Aging; Animals; Cattle; Culture Techniques; Male; Muscle Proteins; Muscles; Oxygen Consumption; Phenylalanine; Sodium-Potassium-Exchanging ATPase; Species Specificity; Tyrosine | 1982 |
Raman spectroscopic study of age-related structural changes in the lens proteins of an intact mouse lens.
Topics: Aging; Animals; Body Water; Crystallins; Disulfides; Lens, Crystalline; Mice; Mice, Inbred ICR; Protein Conformation; Spectrum Analysis, Raman; Tryptophan; Tyrosine | 1983 |
Effect of gammahydroxybutyric acid on catecholamine synthesis and utilization in the developing rat brain.
Topics: Aging; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Female; Hydroxybutyrates; Motor Activity; Norepinephrine; Pregnancy; Rats; Rats, Inbred Strains; Sodium Oxybate; Tyrosine | 1982 |
Newborn phenylalanine/tyrosine metabolism. Implications for screening for phenylketonuria.
Topics: Aging; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mass Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Tyrosine | 1983 |
Age related changes in blood-to-brain amino acid transport and incorporation into brain protein.
Topics: Aging; Amino Acids; Animals; Blood-Brain Barrier; Brain; Kinetics; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Tyrosine; Valine | 1983 |
Age-related alterations in cardiac protein turnover.
Topics: Aging; Animals; Heart; In Vitro Techniques; Insulin; Kinetics; Male; Muscle Proteins; Myocardium; Phenylalanine; Rats; Tyrosine | 1981 |
Effects of centrally and systemically administered L-tyrosine and L-leucine on ovarian function in the old rat.
Topics: Aging; Animals; Catecholamines; Estrus; Female; Leucine; Levodopa; Ovary; Pregnancy; Preoptic Area; Rats; Serotonin; Tyrosine | 1980 |
Secretion of hypothalamic dopamine into pituitary stalk blood of aged female rats.
Topics: Aging; Animals; Dopamine; Estrus; Female; Hypothalamus; Levodopa; Median Eminence; Pituitary Gland; Pregnancy; Prolactin; Rats; Tyrosine | 1981 |
Total tubulin and its aminoacylated and non-aminoacylated forms during the development of rat brain.
Topics: Aging; Animals; Brain; Carboxypeptidases; Carboxypeptidases A; Kinetics; Microtubules; Rats; Tubulin; Tyrosine | 1980 |
Effect of aging on murine macrophages. Diminished response to IFN-gamma for enhanced oxidative metabolism.
Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Caseins; Concanavalin A; Female; Hydrogen Peroxide; Interferon gamma Receptor; Interferon-gamma; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Phosphotyrosine; Receptors, Interferon; Recombinant Proteins; Signal Transduction; Spleen; Tyrosine | 1994 |
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
Topics: Aging; Animals; Blotting, Northern; Choline O-Acetyltransferase; Gene Expression Regulation; Hippocampus; Immunohistochemistry; In Situ Hybridization; Nerve Growth Factors; Phosphotyrosine; Prosencephalon; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Tyrosine | 1995 |
A decreased tubular uptake of dopa results in defective renal dopamine production in aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biological Transport; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Dopamine; Kidney; Kidney Cortex; Male; Microvilli; Monoamine Oxidase; Norepinephrine; Rats; Rats, Wistar; Regression Analysis; Tyrosine | 1995 |
Activation of murine T-cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with aging.
Topics: Aging; Animals; Calcium; CD3 Complex; CD4 Antigens; Cross-Linking Reagents; Isoenzymes; Lymphocyte Activation; Mice; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotransferases; Signal Transduction; Spleen; T-Lymphocytes; Type C Phospholipases; Tyrosine | 1995 |
Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer.
Topics: Adenocarcinoma; Aging; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; DNA; DNA, Neoplasm; Embryonic and Fetal Development; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Molecular Sequence Data; Open Reading Frames; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Rats; Rats, Wistar; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Stomach; Stomach Neoplasms; Tyrosine | 1993 |
Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine.
Topics: Aging; Animals; Blotting, Western; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Intestine, Small; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Proteins; ras GTPase-Activating Proteins; Rats; Rats, Wistar; Signal Transduction; Type C Phospholipases; Tyrosine; Weaning | 1994 |
Racemization of tyrosine in the insoluble protein fraction of brunescent aging human lenses.
Topics: Aging; Chromatography, High Pressure Liquid; Crystallins; Humans; Isomerism; Lens, Crystalline; Magnetic Resonance Spectroscopy; Optical Rotation; Protein Conformation; Spectrometry, Fluorescence; Tyrosine | 1994 |
Epidermal growth factor receptor activation in developing rat kidney.
Topics: Aging; Animals; Enzyme Activation; ErbB Receptors; Female; Gestational Age; Kidney; Male; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Tyrosine | 1994 |
Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets. Effect of age.
Topics: Aging; Animals; Antibodies, Monoclonal; CD3 Complex; CD4-Positive T-Lymphocytes; Concanavalin A; Immunologic Memory; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Phosphorylation; Proteins; Rabbits; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocyte Subsets; Tyrosine | 1993 |
Glutamine force-feeding effect on plasma amino-acid concentrations in growing rats fed a cafeteria diet.
Topics: Aging; Amino Acids; Animals; Cysteine; Diet; Glutamine; Ornithine; Proline; Rats; Rats, Wistar; Threonine; Tyrosine | 1994 |
Glutathione levels of the human crystalline lens in aging and its antioxidant effect against the oxidation of lens proteins.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Cataract; Child; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallins; Glutathione; Glutathione Reductase; Humans; Lens, Crystalline; Middle Aged; Oxidation-Reduction; Protein Binding; Thiobarbituric Acid Reactive Substances; Tryptophan; Tyrosine | 1993 |
Protein synthesis in growing and adult rats on casein and gluten nutrition.
Topics: Aging; Animals; Body Weight; Caseins; Glutens; Male; Protein Biosynthesis; Rats; Rats, Wistar; Regression Analysis; Tyrosine | 1993 |
Local variations in protein structure in the human eye lens: a Raman microspectroscopic study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Crystallins; Eye Proteins; Humans; Lens, Crystalline; Microchemistry; Middle Aged; Phenylalanine; Protein Conformation; Spectrum Analysis, Raman; Tryptophan; Tyrosine | 1993 |
Organ clearance of tyrosyl-arginine and its effect on amino acid metabolism in young sheep.
Topics: Aging; Amino Acids; Analgesics; Animals; Arginine; Citrulline; Endorphins; Female; Hindlimb; Intestinal Mucosa; Intestines; Isoleucine; Kidney; Leucine; Liver; Metabolic Clearance Rate; Organ Specificity; Phenylalanine; Regional Blood Flow; Sheep; Tyrosine; Valine | 1993 |
Delayed detyrosination of alpha-tubulin from parallel fibre axons and its correlation with impaired synaptogenesis in hypothyroid rat cerebellum.
Topics: Aging; Animals; Antibodies, Monoclonal; Axons; Carboxypeptidases; Carboxypeptidases A; Cerebellum; Female; Fluorescent Antibody Technique; Hypothyroidism; Immunohistochemistry; Pregnancy; Rats; Rats, Sprague-Dawley; Synapses; Tubulin; Tyrosine | 1993 |
Gastrin-mediated changes in tyrosine kinases in isolated gastric mucosal cells from young and aged rats.
Topics: Aging; Animals; Cells, Cultured; Gastric Mucosa; Gastrins; Male; Membrane Proteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Time Factors; Tyrosine | 1993 |
Oxidized amino acids in lens protein with age. Measurement of o-tyrosine and dityrosine in the aging human lens.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Crystallins; Humans; Infant; Isomerism; Lens, Crystalline; Middle Aged; Oxidation-Reduction; Spectrometry, Fluorescence; Tyrosine | 1993 |
Neuroamine related compounds in the CSF of hydrocephalic rabbits.
Topics: Aging; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Homovanillic Acid; Hydrocephalus; Hydroxyindoleacetic Acid; Rabbits; Tryptophan; Tyrosine | 1995 |
Increased activation of EGF-receptor tyrosine kinase by EGF and TGF-alpha in the colonic mucosa of aged rats.
Topics: Aging; Animals; Bombesin; Colon; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; In Vitro Techniques; Intestinal Mucosa; Male; Phosphorylation; Rats; Rats, Inbred F344; Transforming Growth Factor alpha; Tyrosine | 1996 |
Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process?
Topics: Aging; Animals; Calcium; Calcium-Transporting ATPases; Male; Muscle, Skeletal; Nitrates; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Tyrosine | 1996 |
Protection of the aged substantia nigra of the rat against oxidative damage by (-)-deprenyl.
Topics: Aging; Animals; Dopamine; Male; Monoamine Oxidase Inhibitors; Oxidative Stress; Rats; Rats, Wistar; Selegiline; Substantia Nigra; Tyrosine | 1996 |
Effect of repeated stress on a number of plasma amino acids and related compounds in young and old rats.
Topics: Age Factors; Aging; Alanine; Amino Acids; Animals; Male; Rats; Rats, Inbred F344; Stress, Physiological; Tyrosine | 1996 |
Divergent selection for high or low growth rate modifies the response of muscle cells to serum or insulin-like growth factor-I in vitro.
Topics: Aging; Analysis of Variance; Animals; Biological Transport; Body Weight; Cell Division; Cells, Cultured; Chickens; DNA; Humans; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Male; Muscle, Skeletal; Protein Biosynthesis; Recombinant Proteins; Thymidine; Tyrosine | 1996 |
Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age.
Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Dimerization; In Vitro Techniques; Lymphocyte Activation; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylation; Receptors, Antigen, T-Cell; Signal Transduction; Tyrosine | 1997 |
Modification of protein surface hydrophobicity and methionine oxidation by oxidative systems.
Topics: Aging; Animals; Methionine; Oxidation-Reduction; Proteins; Rats; Rats, Inbred F344; Tryptophan; Tyrosine | 1997 |
Amino acids suppress proteolysis independent of insulin throughout the neonatal period.
Topics: Aging; Amino Acids; Blood Glucose; Humans; Hydroxylation; Infant, Newborn; Infusions, Intravenous; Insulin; Leucine; Osmolar Concentration; Oxidation-Reduction; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Tyrosine | 1997 |
Oral phenylalanine loading in dopa-responsive dystonia: a possible diagnostic test.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biopterins; Child, Preschool; Dihydroxyphenylalanine; Dopamine Agents; Dystonia; Female; Humans; Male; Middle Aged; Neopterin; Osmolar Concentration; Phenylalanine; Time Factors; Tyrosine | 1997 |
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
Topics: Aging; Animals; Antibodies, Anti-Idiotypic; Antigens, CD; Autoantibodies; B-Lymphocytes; B7-2 Antigen; Calcium-Calmodulin-Dependent Protein Kinases; Chickens; Down-Regulation; Lipopolysaccharides; Membrane Glycoproteins; Mice; Phenotype; Phosphorylation; Pseudogenes; Receptors, IgG; Signal Transduction; src-Family Kinases; Surface Properties; Tyrosine | 1997 |
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.
Topics: Aging; Animals; Blood Vessels; Endothelium, Vascular; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neovascularization, Physiologic; Ovary; Phosphorylation; Rats; Rats, Inbred F344; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Rest; Skin; Tissue Distribution; Tyrosine; Uterus; Wound Healing | 1997 |
Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice.
Topics: Aging; Animals; Brain; Energy Intake; Free Radicals; Hydroxyl Radical; Liver; Male; Mice; Muscle Proteins; Muscle, Skeletal; Myocardium; Oxidation-Reduction; Tyrosine | 1997 |
Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats.
Topics: Aging; Animals; Antioxidants; Biomarkers; Copper; Female; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxyl Radical; Nitrates; Nitrogen; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Serum Albumin, Bovine; Tyrosine | 1998 |
Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats.
Topics: Aging; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Concanavalin A; Enzyme Activation; Enzyme Induction; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Signal Transduction; T-Lymphocytes; Time Factors; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1998 |
Progressive decline in the ability of calmodulin isolated from aged brain to activate the plasma membrane Ca-ATPase.
Topics: Aging; Amino Acid Sequence; Animals; Brain Chemistry; Calcium; Calcium-Transporting ATPases; Calmodulin; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Erythrocyte Membrane; Mass Spectrometry; Methionine; Molecular Sequence Data; Oxidation-Reduction; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Secondary; Rats; Rats, Inbred F344; Spectrometry, Fluorescence; Swine; Thermodynamics; Tryptophan; Tyrosine | 1998 |
Decreased association of p56lck with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging.
Topics: Adult; Aged; Aging; Catalysis; CD4 Antigens; CSK Tyrosine-Protein Kinase; Humans; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mitogens; Phosphorylation; Phytohemagglutinins; Protein-Tyrosine Kinases; src-Family Kinases; T-Lymphocytes; Tyrosine | 1998 |
Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70.
Topics: Adult; Aged; Aging; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Concanavalin A; Down-Regulation; Humans; Mitogens; Phosphorylation; Phytohemagglutinins; Protein-Tyrosine Kinases; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1998 |
Age-induced increase of leucine enkephalin enzyme degradation in human plasma.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopeptidases; Analysis of Variance; Chromatography, Gel; Chromatography, Thin Layer; Enkephalin, Leucine; Female; Glycine; Humans; Hydrolysis; Kinetics; Male; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Tyrosine | 1998 |
Developmental regulation of tyrosine phosphorylation of the NR2D NMDA glutamate receptor subunit in rat central nervous system.
Topics: Aging; Animals; Animals, Newborn; Brain; Enzyme Inhibitors; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Thalamus; Tyrosine; Vanadates | 1998 |
Neuronal and inducible nitric oxide synthase and nitrotyrosine immunoreactivities in the cerebral cortex of the aging rat.
Topics: Aging; Albinism; Animals; Blotting, Western; Cerebral Cortex; Immunohistochemistry; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 1998 |
Immunohistochemical detection of dityrosine in lipofuscin pigments in the aged human brain.
Topics: Aged; Aging; Antibodies; Brain; Brain Chemistry; Humans; Immunohistochemistry; Lipofuscin; Tyrosine | 1998 |
Increased Zap-70 association with CD3zeta in CD4 T cells from old mice.
Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Humans; Jurkat Cells; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylation; Protein-Tyrosine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1998 |
Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo.
Topics: Adaptation, Physiological; Aging; Amino Acids; Animals; Antioxidants; Biomarkers; Female; Motor Activity; Muscle, Skeletal; Muscular Atrophy; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Physical Conditioning, Animal; Rats; Rats, Long-Evans; Rats, Wistar; Tyrosine | 1999 |
Developmental regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor in Torpedo electrocyte.
Topics: Aging; Animals; Blotting, Western; Electric Organ; Fluorescent Antibody Technique; Muscle Proteins; Phosphorylation; Phosphotyrosine; Receptors, Nicotinic; Subcellular Fractions; Tissue Distribution; Torpedo; Tyrosine | 1999 |
Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases.
Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Liver; Male; MAP Kinase Kinase Kinases; Mitogens; Phosphorylation; Proto-Oncogene Proteins c-raf; Rats; Rats, Inbred F344; Tyrosine | 1999 |
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle.
Topics: Aging; Amino Acid Sequence; Animals; Biological Transport; Calcium; Calcium-Transporting ATPases; Cysteine; Endopeptidases; Isoenzymes; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Nitrates; Nitric Oxide; Oxygen; Peptide Fragments; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Sulfhydryl Compounds; Tyrosine | 1999 |
Age-related impairment of p56lck and ZAP-70 activities in human T lymphocytes activated through the TcR/CD3 complex.
Topics: Adult; Aged; Aged, 80 and over; Aging; CD3 Complex; Cell Cycle Proteins; Female; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-vav; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1999 |
Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status.
Topics: Aging; Animals; Biomarkers; Coenzymes; Heart; Humans; Kidney; Liver; Lung; Myocardium; Pyridoxine; Rats; Spleen; Tyrosine; Ubiquinone | 1999 |
Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells.
Topics: Aged; Aged, 80 and over; Aging; CD3 Complex; Cells, Cultured; Enzyme Activation; Humans; Immunologic Memory; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1999 |
Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging.
Topics: Aging; Animals; Calcimycin; Enzyme Activation; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Lymphocytes; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Phosphorylation; Proteins; Rats; Rats, Inbred F344; Signal Transduction; Spleen; Tetradecanoylphorbol Acetate; Transcription Factors; Tyrosine | 2000 |
Tissue-specific regulation of IRS-2/PI 3-kinase association in aged rats.
Topics: Aging; Animals; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Rats; Signal Transduction; Tyrosine | 2000 |
Is nitrotyrosine generated in human erythrocytes in circulation?
Topics: Aging; Animals; Antibodies; Erythrocyte Membrane; Erythrocytes; Hemoglobins; Humans; Membrane Proteins; Rabbits; Ribonuclease, Pancreatic; Tyrosine | 2000 |
Age-related changes in microtubules in the guinea pig organ of Corti. Tubulin isoform shifts with increasing age suggest changes in micromechanical properties of the sensory epithelium.
Topics: Acetylation; Aging; Animals; Deafness; Female; Guinea Pigs; Immunohistochemistry; Mechanoreceptors; Microscopy, Fluorescence; Microtubules; Organ of Corti; Protein Processing, Post-Translational; Tubulin; Tyrosine | 2000 |
Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Female; Humans; Male; Middle Aged; Tyrosine | 1999 |
Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4.
Topics: Adipocytes; Aging; Animals; Electrophoresis, Polyacrylamide Gel; Glucose; Glucose Transporter Type 4; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Monosaccharide Transport Proteins; Muscle Proteins; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; Signal Transduction; Tyrosine; Vanadates | 2000 |
Hepatic growth hormone signaling in the late gestation fetal rat.
Topics: Aging; Animals; Cells, Cultured; DNA-Binding Proteins; Fetus; Gestational Age; Growth Hormone; Human Growth Hormone; Humans; Injections, Intraperitoneal; Liver; Phosphorylation; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Somatotropin; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Tyrosine | 2000 |
Noninvasive assessment of aromatic L-amino acid decarboxylase activity in aging rhesus monkey brain in vivo.
Topics: Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Dihydroxyphenylalanine; Macaca mulatta; Male; Neurons; Tomography, Emission-Computed; Tyrosine | 2001 |
Enhanced peroxynitrite formation is associated with vascular aging.
Topics: Acetylcholine; Aging; Animals; Aorta; Body Weight; Calcimycin; Cellular Senescence; Endothelium, Vascular; Enzyme Induction; Hemodynamics; Male; Microscopy, Immunoelectron; Mitochondria; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxidative Stress; Rats; Rats, Inbred Strains; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation | 2000 |
Oxidative-stress-dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats.
Topics: Aging; Animals; Blotting, Western; Central Nervous System; Cerebellum; Cyclic N-Oxides; Free Radical Scavengers; Hippocampus; Immunohistochemistry; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxygen; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Tyrosine; Up-Regulation | 2001 |
Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis.
Topics: Aging; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Collagen; Cysteine Endopeptidases; DNA Fragmentation; Gene Expression Regulation, Enzymologic; Image Processing, Computer-Assisted; In Situ Nick-End Labeling; Male; Multienzyme Complexes; Muscle, Smooth; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penis; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tyrosine; Ubiquitins | 2001 |
Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain.
Topics: Aging; Animals; Brain; Lipid Peroxidation; Male; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Sulfhydryl Compounds; Tyrosine | 2001 |
Expression of Ly49E and CD94/NKG2 on fetal and adult NK cells.
Topics: Aging; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Ly; beta 2-Microglobulin; Cell Differentiation; Cytotoxicity Tests, Immunologic; Fetus; Immunologic Memory; Killer Cells, Natural; Lectins, C-Type; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NK Cell Lectin-Like Receptor Subfamily A; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Phosphorylation; Rats; Rats, Inbred F344; Receptors, Immunologic; Receptors, KIR; Receptors, Natural Killer Cell; Receptors, NK Cell Lectin-Like; Spleen; T-Lymphocyte Subsets; Thymus Gland; Tumor Cells, Cultured; Tyrosine | 2001 |
PTH stimulates PLCbeta and PLCgamma isoenzymes in rat enterocytes: influence of ageing.
Topics: Aging; Animals; Benzoquinones; Blotting, Western; Cells, Cultured; Duodenum; Electrophoresis, Polyacrylamide Gel; Enterocytes; Genistein; Inositol Phosphates; Isoenzymes; Lactams, Macrocyclic; Male; Parathyroid Hormone; Phospholipase C beta; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Isoforms; Proto-Oncogene Proteins pp60(c-src); Quinones; Rats; Rats, Wistar; Rifabutin; Subcellular Fractions; Time Factors; Type C Phospholipases; Tyrosine | 2001 |
Developmental changes in cerebrospinal fluid concentrations of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy.
Topics: Adolescent; Age Factors; Aging; Biogenic Monoamines; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Myoclonic Epilepsies, Progressive; Tryptophan; Tyrosine | 2001 |
Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function.
Topics: Aging; Animals; Apoptosis; Biomarkers; Gonadotropin-Releasing Hormone; Hypothalamus; Immunohistochemistry; In Situ Nick-End Labeling; Male; Microscopy, Fluorescence; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxytocin; Rats; Rats, Inbred BN; Reproduction; Tyrosine | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats.
Topics: Aging; Animals; Brain; Energy Metabolism; Female; Free Radicals; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Oxidative Phosphorylation; Proteins; Rats; Rats, Wistar; Tyrosine | 2001 |
Cyclodextrin modulation of T lymphocyte signal transduction with aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; beta-Cyclodextrins; Cell Division; Cell Membrane; Cells, Cultured; Cholesterol; Cyclodextrins; DNA-Binding Proteins; Enzyme Activation; Female; Humans; Janus Kinase 3; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine | 2001 |
Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain Chemistry; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Fever; Homovanillic Acid; Male; Methamphetamine; Nitrates; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Hyperthermia induces gene expression of heat shock protein 70 and phosphorylation of mitogen activated protein kinases in the rat cerebellum.
Topics: Aging; Animals; Animals, Newborn; Cerebellum; ErbB Receptors; Fever; Gene Expression Regulation, Enzymologic; HSP70 Heat-Shock Proteins; Hyperthermia, Induced; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA, Messenger; Stress, Physiological; Tyrosine | 2001 |
Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells.
Topics: Aging; Animals; Cells, Cultured; Collagen Type II; Collagen Type XI; Gene Expression; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Intervertebral Disc; Male; Phosphoproteins; Phosphorylation; Proteoglycans; Rats; Rats, Wistar; Receptor, IGF Type 1; Sacrococcygeal Region; Tyrosine | 2001 |
The nitrite/collagen reaction: non-enzymatic nitration as a model system for age-related damage.
Topics: Aging; Collagen Type I; Humans; Nitrates; Nitrogen; Tyrosine | 2001 |
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents.
Topics: Aging; Animals; Behavior, Animal; DNA, Mitochondrial; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hippocampus; Learning Disabilities; Male; Neurons; Nucleic Acids; Oxidation-Reduction; Oxidative Stress; Rats; RNA, Messenger; Space Perception; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Effect of age and oxidative stress on tyrosine phosphorylation of ZAP-70.
Topics: Adult; Aged; Aging; Antibodies, Monoclonal; CD3 Complex; Cells, Cultured; Humans; Oxidative Phosphorylation; Oxidative Stress; Protein-Tyrosine Kinases; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 2002 |
Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets.
Topics: Adult; Aged; Aging; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Female; Humans; Interferon-gamma; Interleukin-2; Ionomycin; Lectins, C-Type; Lymphocyte Activation; Lymphocyte Count; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Plasma protein oxidation is associated with an increase of procoagulant markers causing an imbalance between pro- and anticoagulant pathways in healthy subjects.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Blood Proteins; Child; Child, Preschool; Female; Fibrinopeptide A; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Prothrombin; Reference Values; Thrombomodulin; Tyrosine; Vitamin E; von Willebrand Factor | 2002 |
Age-related changes in the distribution of nitrotyrosine in the cerebral cortex and hippocampus of rats.
Topics: Aging; Animals; Cerebral Cortex; Hippocampus; Image Processing, Computer-Assisted; Interneurons; Oxidative Stress; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy.
Topics: Aging; Amidines; Animals; Animals, Newborn; Apoptosis; Benzylamines; Cell Count; Crosses, Genetic; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Proteins; Retina; Retinal Diseases; Retinal Vein Occlusion; Tyrosine | 2002 |
Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Aging; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; CHO Cells; Cloning, Molecular; Cricetinae; Female; Humans; Insulin; Isoenzymes; Male; Mice; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Sequence Alignment; Spermatogenesis; src-Family Kinases; Testis; Tyrosine; Vanadates | 2002 |
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aging; Animals; Arginine; Arterioles; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Immunohistochemistry; In Vitro Techniques; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tyrosine; Vasodilation; Xanthine Oxidase | 2002 |
Transfer RNA in aging Drosophila: II. Isoacceptor patterns.
Topics: Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Asparagine; Drosophila melanogaster; Histidine; Leucine; Male; RNA, Transfer; Tyrosine | 1979 |
[Changes of various biochemical indicators in osteochondrosis in relation to age].
Topics: Adolescent; Adult; Aging; Blood Proteins; Glycosaminoglycans; Hexosamines; Humans; Hydroxyproline; Intervertebral Disc; Middle Aged; Osteochondritis; Sialic Acids; Tyrosine | 1976 |
The content of dityrosine in chick and rabbit aorta proteins.
Topics: Aging; Amino Acids; Animals; Aorta; Chemical Phenomena; Chemistry; Elastin; Female; Glycoproteins; Pregnancy; Rabbits; Tyrosine | 1979 |
Age related changes in hormone binding by target cells and tissues; possible role in altered adaptive responsiveness.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Aging; Animals; Aorta; Child; Female; Glucocorticoids; Glucose; Gonadal Steroid Hormones; Hormones; Humans; Hydrocortisone; Insulin; Insulin Secretion; Isoproterenol; Lipid Metabolism; Male; Middle Aged; Receptors, Cell Surface; Salivary Glands; Thyroid Hormones; Tyrosine; Tyrosine Transaminase | 1975 |
Age related changes in the effect of electroconvulsive shock (ECS) on the in vivo hydroxylation of tyrosine and tryptophan in rat brain.
Topics: 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benzyl Alcohols; Brain; Dihydroxyphenylalanine; Electroshock; Hydrazines; Male; Rats; Tryptophan; Tyrosine | 1977 |
Lipid pigment formation in cultures of chick hepatocytes. Effects of aging and of oxidizable agents.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Chick Embryo; Iron; Lipid Metabolism; Lipofuscin; Liver; Oxidation-Reduction; Pigments, Biological; Tyrosine | 1977 |
Polyphenol oxidase as a factor in aging.
Topics: Aging; Animals; Catechol Oxidase; Mathematics; Plants; Proteins; Tyrosine | 1977 |
Compartments of protein metabolism in the developing brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Kinetics; Mathematics; Mice; Nerve Tissue Proteins; Rats; Species Specificity; Tyrosine | 1979 |
[Senile liver and its repercussions on cerebral activity].
Topics: Aged; Aging; Amino Acids; Brain; Cystine; Glutamates; Histidine; Humans; Liver; Serine; Threonine; Tyrosine | 1979 |
Induced PKU in rats: effects of age and melatonin treatment.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Female; Humans; Learning; Melatonin; Phenylalanine; Phenylketonurias; Pregnancy; Rats; Time Factors; Tyrosine | 1977 |
Catecholamine synthesis in brain of ageing rat.
Topics: Aging; Animals; Brain; Catecholamines; Male; Rats; Tyrosine | 1978 |
Modification of the C-terminus of brain tubulin during development.
Topics: Aging; Amino Acids; Animals; Brain; Carboxypeptidases; Chickens; Glycoproteins; Kinetics; Tubulin; Tyrosine | 1978 |
Post-natal changes in the transport of aromatic amino acids into the brain [proceedings].
Topics: Aging; Amino Acids; Animals; Biological Transport; Brain; Phenylalanine; Rats; Tryptophan; Tyrosine | 1978 |
Age-dependent changes in central dopaminergic and other monoaminergic systems.
Topics: Aging; Animals; Avoidance Learning; Biogenic Amines; Castration; Child; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Neurons; Penfluridol; Pimozide; Rats; Receptors, Dopamine; Tyrosine | 1978 |
Testing the protein error hypothesis of ageing in Drosophila.
Topics: Aging; Animals; Drosophila melanogaster; Ethionine; Half-Life; Male; Phenylalanine; Proteins; Tryptophan; Tyrosine | 1976 |
Age-related changes in protein turnover and ribonucleic acid of the diaphragm muscle of normal and dystrophic hamsters.
Topics: Aging; Animals; Cricetinae; Diaphragm; Muscle Proteins; Muscles; Muscular Dystrophy, Animal; RNA; Tyrosine | 1977 |
Tryptophan and 5-hydroxytryptamine metabolism in the immature rat brain during recovery from asphyxia.
Topics: Aging; Animals; Asphyxia; Blood Proteins; Brain; Brain Chemistry; Female; Hydroxyindoleacetic Acid; Male; Protein Binding; Rats; Serotonin; Tryptophan; Tyrosine | 1977 |
Reinstatement of vaginal cycles in aged female rats.
Topics: Aging; Animals; Benserazide; Carbidopa; Dose-Response Relationship, Drug; Drug Interactions; Estrus; Female; Fusaric Acid; Hypophysectomy; Levodopa; Phenoxybenzamine; Pimozide; Pregnancy; Propranolol; Rats; Tyrosine; Vagina | 1976 |
Blood-brain barrier: selective changes during maturation.
Topics: Aging; Animals; Blood-Brain Barrier; Cerebellum; Cerebral Cortex; Chick Embryo; Chickens; Glucose; Inulin; Proline; Structure-Activity Relationship; Tectum Mesencephali; Tyrosine | 1976 |
Aging and the passage of L-tyrosine, L-DOPA, and inulin into mouse brain slices in vitro.
Topics: Aging; Animals; Biological Transport, Active; Brain; Brain Stem; Corpus Striatum; Hypothalamus; In Vitro Techniques; Inulin; Levodopa; Male; Mice; Mice, Inbred C57BL; Tritium; Tyrosine | 1975 |
An enzyme tyrosylating alpha-tubulin and its role in microtubule assembly.
Topics: Aging; Animals; Brain; Cattle; Colchicine; Kinetics; Ligases; Microtubules; Nerve Tissue Proteins; Rats; Receptors, Drug; Species Specificity; Time Factors; Tubulin; Tyrosine | 1975 |
Ageing and dopamine uptake by subcellular fractions of the C57BL/6J male mouse brain.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Hypothalamus; Kinetics; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Serotonin; Synaptosomes; Tyrosine | 1975 |
Pyridoxal-5-phosphate levels in rat brain assayed by a modified method using enzymic decarboxylation of L-[14C]tyrosine.
Topics: Aging; Animals; Brain; Brain Chemistry; Kinetics; Methods; Microchemistry; Pyridoxal Phosphate; Rats; Tyrosine; Tyrosine Decarboxylase; Vitamin B 6 Deficiency | 1976 |
Defects of insulin's signal transduction in old rat livers.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Female; Glucose; Immunoblotting; Injections, Intravenous; Insulin; Insulin Resistance; Liver; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Signal Transduction; Time Factors; Tyrosine | 1992 |
Dopaminergic neuron development in rats: biochemical study from prenatal life to adulthood.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Female; Hydroxyindoleacetic Acid; Mesencephalon; Nerve Tissue Proteins; Nervous System; Neurons; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Serotonin; Tyrosine | 1992 |
Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice.
Topics: Aging; Animals; Antibodies; Autoradiography; Blotting, Western; Concanavalin A; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; T-Lymphocytes; Time Factors; Tyrosine | 1992 |
Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1.
Topics: Aging; Animals; Diaphragm; Diet; Insulin-Like Growth Factor I; Liver; Male; Mice; Mice, Inbred C57BL; Myocardium; Phenylalanine; Protein Biosynthesis; Specific Pathogen-Free Organisms; Time Factors; Tissue Distribution; Tyrosine | 1992 |
o-Tyrosine and dityrosine concentrations in oxidized proteins and lens proteins with age.
Topics: Aging; Eye Proteins; Humans; Lens, Crystalline; Oxidation-Reduction; Tyrosine | 1992 |
Morphological and biochemical changes in gastric mucosa of aging rats.
Topics: Aging; Animals; Atrophy; Blotting, Western; Collagen; Gastric Mucosa; Male; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Tyrosine | 1990 |
[Age changes in concentrations of monoamines and related substances in the cerebrospinal fluid].
Topics: Adolescent; Adult; Aged; Aging; Biogenic Monoamines; Child; Chromatography, High Pressure Liquid; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Neurotransmitter Agents; Norepinephrine; Tryptophan; Tyrosine | 1991 |
Signal transduction in human B cells during aging: alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness.
Topics: Aging; Amino Acids; B-Lymphocytes; Calcium; Cell Division; Cells, Cultured; Cytosol; Humans; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Ribonucleases; Serine; Signal Transduction; Threonine; Tyrosine | 1991 |
Delayed plasma clearance of phenylalanine and tyrosine in elderly men.
Topics: Adult; Aged; Aging; Amino Acids; Dementia; Enteral Nutrition; Humans; Middle Aged; Phenylalanine; Tyrosine | 1991 |
Effects of hypothyroidism on the detyrosylation of alpha-tubulin in the parallel fibers of the developing rat cerebellar cortex.
Topics: Aging; Animals; Antibodies, Monoclonal; Cerebellar Cortex; Hypothyroidism; Immunohistochemistry; Neurons; Rats; Rats, Inbred Strains; Synapses; Thyroxine; Tubulin; Tyrosine | 1991 |
Neuronal tyrosine phosphorylation in growth cone glycoproteins.
Topics: Aging; Animals; Animals, Newborn; Axons; Brain; Cell Membrane; Glycoproteins; Growth Substances; Kinetics; Molecular Weight; Phosphorylation; Protein-Tyrosine Kinases; Rats; Substrate Specificity; Tyrosine | 1990 |
Regional distribution of 3-O-methyl-DOPA in the cortex and subcortical structures in the rat: effect of aging.
Topics: Aging; Animals; Brain; Cerebral Cortex; Male; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Intestinal transport during the life span of the mouse.
Topics: 3-O-Methylglucose; Aging; Animals; Biological Transport; Glucose; Intestinal Absorption; Intestine, Small; Male; Methylglucosides; Methylglycosides; Mice; Mice, Inbred C57BL; Tyrosine | 1990 |
Effects of aging and xerosis on the amino acid composition of human skin.
Topics: Aging; Amino Acids; Female; Filaggrin Proteins; Glycine; Humans; Ichthyosis; Leucine; Phenylalanine; Skin; Tyrosine | 1990 |
Tyrosine phosphorylation in the postnatal rat brain: a developmental, immunohistochemical study.
Topics: Aging; Animals; Brain Stem; Cerebellum; Immunohistochemistry; Olfactory Bulb; Phosphorylation; Rats; Rats, Inbred Strains; Tyrosine | 1989 |
Postnatal development of the innervation and paraganglia in the porcine pulmonary arterial bed.
Topics: Aging; Animals; Animals, Newborn; Intermediate Filaments; Neuropeptides; Paraganglia, Nonchromaffin; Pulmonary Artery; Swine; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin Thiolesterase | 1988 |
Relationship between the tyrosination state of tubulin and the activities of tubulin:tyrosine ligase and tubulin carboxypeptidase in rat muscle during development.
Topics: Aging; Animals; Animals, Newborn; Carboxypeptidases; Kinetics; Muscle Development; Muscles; Peptide Synthases; Protein Processing, Post-Translational; Rats; Tubulin; Tyrosine | 1988 |
Fidelity of aminoacylation by rat-liver tyrosyl-tRNA synthetase. Effect of age.
Topics: Acylation; Age Factors; Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Binding Sites; Binding, Competitive; Biological Transport; Electrophoresis, Polyacrylamide Gel; Liver; Male; Phenylalanine; Protein Biosynthesis; Rats; Rats, Inbred F344; RNA, Transfer; Tyrosine; Tyrosine-tRNA Ligase | 1988 |
Raman spectroscopic evaluation of aging and long-wave UV exposure in the guinea pig lens: a possible model for human aging.
Topics: Aging; Animals; Disulfides; Guinea Pigs; Lens, Crystalline; Phenylalanine; Protein Conformation; Spectrum Analysis, Raman; Sulfhydryl Compounds; Tryptophan; Tyrosine; Ultraviolet Rays | 1988 |
Effect of aging on intestinal absorption of aromatic amino acids in vitro in the rat.
Topics: Aging; Animals; In Vitro Techniques; Intestinal Absorption; Jejunum; Kinetics; Male; Phenylalanine; Rats; Rats, Inbred F344; Tryptophan; Tyrosine | 1988 |
Developmental studies on the uptake of tyrosine by synaptosomes and plasma membrane vesicles derived from rat brain. Effect of thyroid hormones.
Topics: Aging; Animals; Biological Transport, Active; Brain; Rats; Rats, Inbred Strains; Sodium; Subcellular Fractions; Synaptosomes; Triiodothyronine; Tyrosine | 1986 |
Distribution of aromatic and fluorescent compounds within single human lenses.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Fluorescence; Humans; Lens, Crystalline; Middle Aged; Tryptophan; Tyrosine; Uric Acid | 1987 |
Sclerotization of mosquito cuticle.
Topics: Aedes; Aging; Animals; Anopheles; Culex; Pupa; Species Specificity; Tyrosine | 1987 |
The effect of sympathectomy upon iris tyrosinase activity.
Topics: Aging; Animals; Catechol Oxidase; Iris; Monophenol Monooxygenase; Pigment Epithelium of Eye; Rabbits; Sympathectomy; Tyrosine | 1985 |
[Quantitative cytochemistry of the inner ear of the young and senile guinea pig].
Topics: Aging; Animals; Ear, Inner; Guinea Pigs; Histocytochemistry; Microscopy; Organ of Corti; Photometry; Proteins; RNA; Staining and Labeling; Tritium; Tryptophan; Tyrosine; Ultraviolet Rays | 1970 |
Nutrient transfer during the reproductive cycle in Glossina austeni Newst.: histology and histochemistry of the milk gland, fat body, and oenocytes.
Topics: Adipose Tissue; Aging; Animals; Female; Genitalia, Female; Histocytochemistry; Larva; Milk Proteins; Peroxidases; Pregnancy; Reproduction; Staining and Labeling; Tsetse Flies; Tyrosine | 1973 |
Amyloid in normal and pathological parathyroid glands.
Topics: Aging; Amyloid; Amyloidosis; Autopsy; Histocytochemistry; Humans; Parathyroid Glands; Staining and Labeling; Thyroidectomy; Tryptophan; Tyrosine | 1974 |
Proteolytic activity in muscles of old animals.
Topics: Aging; Animals; Female; Muscle Denervation; Muscle Proteins; Muscles; Peptide Hydrolases; Rats; Serum Albumin; Serum Globulins; Spectrophotometry; Subcellular Fractions; Tyrosine | 1965 |
Adrenergic neurohumors in the heart of hamsters with hereditary myopathy during cardiac hypertrophy and failure.
Topics: Aging; Animals; Cardiomegaly; Cricetinae; Dopamine; Heart; Heart Failure; Myocardial Contraction; Myocardium; Norepinephrine; Organ Size; Tyrosine | 1972 |
Activity of the phenylalanine hydroxylating system in liver of newborn, suckling and adult rats.
Topics: Aging; Aldehydes; Animals; Animals, Newborn; Body Weight; Carbon Isotopes; Female; Kinetics; Liver; Male; Mixed Function Oxygenases; NAD; Organ Size; Phenylalanine; Proteins; Rats; Tyrosine | 1969 |
Ontogeny of soluble and mitochondrial tyrosine aminotransferases.
Topics: Aging; Animals; Animals, Newborn; Biological Evolution; Female; Fetus; Haplorhini; Mitochondria, Liver; Pregnancy; Tyrosine; Tyrosine Transaminase | 1969 |
Aromatic amino acid metabolism in the wabbler-lethal mouse.
Topics: Aging; Animals; Liver; Mice; Mixed Function Oxygenases; Nervous System Diseases; Phenylalanine; Rodent Diseases; Transaminases; Tryptophan; Tryptophan Oxygenase; Tyrosine; Tyrosine Transaminase | 1969 |
Plasma tryptophan and 5-HT metabolism in the CNS of the newborn rat.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Blood-Brain Barrier; Brain; Brain Stem; Chlordiazepoxide; Chromatography, Gel; Chromatography, Ion Exchange; Female; Hydroxyindoleacetic Acid; In Vitro Techniques; Kinetics; Male; Organ Specificity; Pregnancy; Rats; Salicylates; Serotonin; Time Factors; Tritium; Tryptophan; Tyrosine; Ultrafiltration | 1974 |
Disappearance of tyrosine residues in collagen with age. Suggestion of a possible reaction mechanism.
Topics: Achilles Tendon; Aging; Amino Acids; Aniline Compounds; Animals; Anisoles; Biphenyl Compounds; Cattle; Collagen; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Nitrates; Nitrobenzenes; Oxidation-Reduction; Pronase; Rats; Solubility; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Tail; Temperature; Tendons; Tyrosine | 1974 |
Age-associated changes of an amyloid related serum component.
Topics: Acute Disease; Adolescent; Adult; Aged; Aging; Amyloid; Amyloidosis; Arteriosclerosis; Child; Child, Preschool; Chromatography, Gel; Chronic Disease; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Iodine Radioisotopes; Middle Aged; Osteoarthritis; Pregnancy; Radioimmunoassay; Tyrosine | 1974 |
Neonatal 6-hydroxydopamine treatment: noradrenaline levels and in vitro 3H-catecholamine synthesis in discrete brain regions of adult rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Catecholamines; Chromatography; Dopamine; Drug Administration Schedule; Hydroxydopamines; Male; Norepinephrine; Rats; Rats, Inbred Strains; Tyrosine | 1974 |
Occurrence and distribution of aromatic L-amino acid (L-DOPA) decarboxylase in the human brain.
Topics: 5-Hydroxytryptophan; Aged; Aging; Animals; Basal Ganglia; Brain; Carbon Isotopes; Cats; Cattle; Caudate Nucleus; Cerebral Cortex; Chromatography, Paper; Diencephalon; Dopa Decarboxylase; Enzyme Activation; Female; Haplorhini; Humans; Hypothalamus; Male; Mesencephalon; Middle Aged; Pineal Gland; Pyridoxal Phosphate; Rats; Species Specificity; Stereoisomerism; Tyrosine | 1972 |
Catecholamine metabolism in the brains of ageing male mice.
Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Corpus Striatum; Dihydroxyphenylalanine; DNA; Dopa Decarboxylase; Dopamine; Fluorometry; Hypothalamus; Male; Mice; Norepinephrine; Organ Size; Tritium; Tyrosine | 1973 |
Relationship of protein metabolism to senescence of corn (Zea mays L.) stalk parenchyma, cob parenchyma and first developed leaf tissues.
Topics: Aging; Alanine; Amino Acids; Aspartic Acid; Carbon Isotopes; Cell Count; Chromatography; Dactinomycin; Glutamine; Leucine; Models, Biological; Ornithine; Phenylalanine; Plant Proteins; Plants; Ribonucleases; Ribosomes; RNA; RNA, Messenger; Threonine; Time Factors; Tyrosine | 1973 |
Uncorporation of phenylalanine as a single unit into rat brain protein: reciprocal inhibition by phenylalanine and tyrosine of their respective incorporations.
Topics: Adenosine Triphosphate; Aging; Animals; Asparagine; Brain; Carbon Radioisotopes; Glutamates; Glutamine; Histidine; In Vitro Techniques; Kidney; Kinetics; Liver; Magnesium; Methionine; Nerve Tissue Proteins; Phenylalanine; Potassium; Rats; Thyroid Gland; Tritium; Tryptophan; Tyrosine | 1973 |
Some biochemical and histochemical properties of the age pigment in the human intervertebral disc.
Topics: Adolescent; Adult; Aged; Aging; Chromatography, Thin Layer; Histocytochemistry; Humans; Intervertebral Disc; Lipids; Microchemistry; Middle Aged; Pigments, Biological; Triglycerides; Tyrosine | 1973 |
Lipid metabolism in liver and brain in acute hyperphenylalaninemia in rats of different ages. Correlation with tissue phenylalanine and tyrosine levels.
Topics: Acetates; Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Cholesterol; Chromatography, Thin Layer; Female; Glycolipids; Lipid Metabolism; Liver; Phenylalanine; Phenylalanine Hydroxylase; Phospholipids; Rats; Time Factors; Tyrosine | 1974 |
Free amino acids in developing rat retina.
Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Differentiation; Chromatography, Ion Exchange; Glutamates; Glutamine; Glycine; Histidine; Methionine; Ornithine; Proline; Rats; Retina; Taurine; Time Factors; Tyrosine | 1974 |
Arterial mesenchyme and arteriosclerosis. Enzymic vs non-enzymic factors in the deterioration of connective tissue.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Animals; Aorta; Arteries; Arteriosclerosis; Blood Platelets; Cattle; Child; Collagen; Connective Tissue; Culture Techniques; Elastic Tissue; Elastin; Female; Fluorescence; Humans; Leukocytes; Male; Middle Aged; Pancreatic Elastase; Phenylalanine; Pregnancy; Proteins; Solubility; Tyrosine; Ultraviolet Rays; X-Ray Diffraction | 1974 |
Amino acid incorporation and aminoacyl transfer in an insect pupal system.
Topics: Adenosine Triphosphate; Aging; Amino Acids; Animals; Carbon Isotopes; Coleoptera; Escherichia coli; Guanine Nucleotides; Leucine; Liver; Magnesium; Metamorphosis, Biological; Microsomes; Potassium; Puromycin; Rabbits; Ribonucleases; Ribosomes; RNA, Transfer; Tyrosine; Ultracentrifugation | 1968 |
L-tyrosine-3,5-3H assay for tyrosinase development in skin of newborn hamsters.
Topics: Aging; Animals; Animals, Newborn; Catechol Oxidase; Cricetinae; Fetus; Skin; Tritium; Tyrosine | 1969 |
An accurate method of determining age in small mammals.
Topics: Aging; Animals; Female; Lens, Crystalline; Male; Mammals; Methods; Mice; Time Factors; Tyrosine | 1972 |
The effect of diet upon the excretion of parahydroxy-phenylacetic acid and creatinine in man.
Topics: Administration, Oral; Adolescent; Adult; Aging; Child; Child, Preschool; Creatinine; Diet; Female; Humans; Hydrogen-Ion Concentration; Infant; Male; Middle Aged; Phenols; Phenylacetates; Time Factors; Tyrosine | 1972 |
[Biochemical studies on the age-related variations of the human intervertebral disc].
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Chromatography; Collagen; Galactosamine; Glucosamine; Hexosamines; Humans; Infant; Intervertebral Disc; Lumbar Vertebrae; Middle Aged; Phenylalanine; Potassium; Sodium; Thoracic Vertebrae; Tryptophan; Tyrosine | 1972 |
Variations in oral tissues as associated with ageing.
Topics: Aging; Animals; Gingiva; Guinea Pigs; Hexoses; Histocytochemistry; In Vitro Techniques; Male; Mouth Mucosa; Palate; Tyrosine | 1967 |
[The amino acid composition of human lens proteins in the course of lens alterations and cataract transformation. I. The amino acid composition of unclouded human lenses of various age groups].
Topics: Adult; Age Factors; Aged; Aging; Alanine; Amino Acids; Arginine; Asparagine; Cataract; Crystallins; Glutamates; Glycine; Humans; Isoleucine; Lens, Crystalline; Leucine; Lysine; Middle Aged; Nitrogen; Peptide Hydrolases; Phenylalanine; Tyrosine | 1966 |
Subunit structure of rabbit muscle aldolase: extent of homology of the alpha and beta subunits and age-dependent changes in their ratio.
Topics: Aging; Amino Acids; Animals; Bromine; Carboxypeptidases; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cyanides; Electrophoresis, Disc; Female; Fructose-Bisphosphate Aldolase; Histidine; Male; Muscles; Peptides; Rabbits; Trypsin; Tyrosine; Urea | 1969 |
Age-dependent changes in the human intervertebral disc. Fluorescent substances and amino acids in the anulus fibrosus.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Amino Acids; Fluorescence; Glucosamine; Hexosamines; Humans; Hydroxyproline; Intervertebral Disc; Microscopy, Fluorescence; Middle Aged; Spectrophotometry; Tyrosine | 1970 |
Appearance and concentrations of catecholamines and their biosynthesis in the embryonic and developing chick.
Topics: Aging; Animals; Catecholamines; Chick Embryo; Chickens; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Epinephrine; Mixed Function Oxygenases; Myocardium; Norepinephrine; Transferases; Tritium; Tyrosine | 1968 |
The free amino acids in the haemolymph of the maturing adult boll weevil, Anthonomus grandis Boheman.
Topics: Aging; Amino Acids; Animals; Chromatography; Chromatography, Thin Layer; Coleoptera; Electrophoresis; Female; Hemolymph; Male; Nitrogen; Sex; Tyrosine | 1968 |
Hyperphenylalaninemia: effect on the developing rat brain.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Humans; Injections, Subcutaneous; Lipid Metabolism; Liver; Mixed Function Oxygenases; Myelin Sheath; Organ Size; Phenylalanine; Phenylketonurias; Rats; Tyrosine | 1969 |
Proteolytic activity in muscles of old animals.
Topics: Aging; Animals; Female; Muscle Denervation; Muscle Proteins; Muscles; Peptide Hydrolases; Rats; Serum Albumin; Serum Globulins; Spectrophotometry; Subcellular Fractions; Tyrosine | 1965 |
Relationship between age and haemoglobin-splitting activity in chicken muscle.
Topics: Aging; Animals; Cathepsins; Hemoglobins; Muscles; Poultry; Proteins; Tyrosine | 1966 |