tyrosine and Aging

tyrosine has been researched along with Aging in 345 studies

Research

Studies (345)

TimeframeStudies, this research(%)All Research%
pre-199089 (25.80)18.7374
1990's62 (17.97)18.2507
2000's114 (33.04)29.6817
2010's68 (19.71)24.3611
2020's12 (3.48)2.80

Authors

AuthorsStudies
Garg, G; Rizvi, SI; Singh, AK; Singh, S; Verma, AK1
Arenas-Ríos, E; Arteaga-Silva, M; Ávalos-Rodríguez, A; Cortés-Barberena, E; Konigsberg, M; López-Trinidad, BP; Rodríguez-Tobón, A; Vigueras-Villaseñor, RM1
Hu, D; Hu, L; Jiao, DL; Ju, XY; Li, GN; Li, X; Liu, SM; Ma, BZ; Qi, L; Si, SH; Zhao, C; Zhao, SY; Zhou, S1
Krajek, AC; Lang, JA; Rand, JE; Schwartz, KS1
Botta, A; Dadlani, H; Elango, R; Ghosh, S; Jiayu, Y; Rasmussen, B; Renaud, LM; Simtchouk, S; Winkler, J1
Inoue, H; Ishibashi, T; Itabe, H; Kamioka, M; Koyama, H; Ohkawara, H; Ohtsuka, S; Shiomi, M; Sugimoto, K; Uekita, H; Wada, I; Yamagishi, S; Yamamoto, H; Yasuchika, T1
Bai, P; Chen, F; Chen, J; Li, M; Mao, D; Wang, R; Yang, L; Yang, X; Zhang, Y; Zhao, W1
Brunt, VE; Casso, AG; Davy, KP; Gioscia-Ryan, RA; Neilson, AP; Richey, JJ; Sapinsley, ZJ; Seals, DR; VanDongen, NS; Ziemba, BP; Zigler, MC1
Chen, P; Li, X; Liang, G; Ling, X; Shi, Z; Wang, F; Wei, M; Zhang, J; Zhang, T; Zhao, C1
Asara, JM; Binari, R; Brockmann, A; Cracan, V; Filine, E; Leshchiner, D; Olsen, AL; Parkhitko, AA; Perrimon, N; Rabinowitz, JD; Ramesh, D; Wang, L1
Bailey, WM; Gensel, JC; McFarlane, KE; Patel, SP; Slone, SA; Stewart, AN; Sullivan, PG; Tranthem, LA; Vekaria, HJ; Zhang, B1
Hasan, M; Jung, BH; Kwon, OS; Lee, G; Lee, SH; Seo, JE1
Alfano, R; Balta, C; Cotoraci, C; D'Amico, M; Galdiero, M; Gesualdo, C; Gharbia, S; Gherghiceanu, M; Herman, H; Hermenean, A; Mladin, B; Peteu, VE; Petrillo, F; Rossi, S; Trotta, MC1
Chang, F; Flavahan, NA; Flavahan, S1
Damanhuri, HA; Durani, LW; Hamezah, HS; Ibrahim, NF; Makpol, S; Tooyama, I; Yanagisawa, D1
Aarts, E; Bloemendaal, M; de Heus, R; van de Rest, O1
Brandmaier, AM; Colzato, L; Düzel, S; Gallinat, J; Kühn, S; Lindenberger, U; Norman, K; Widaman, KF1
Liu, HM; Liu, JD; Ma, N; Wang, XZ; Xia, T1
Dodos, M; Janssen, WG; Mazid, S; McEwen, BS; Milner, TA; Morrison, JH; Puri, R; Waters, EM1
Breevoort, SR; Dobson, PS; Donato, AJ; Durrant, JR; Islam, MT; Lesniewski, LA; Liu, Y; Machin, DR; Meza, AJ; Nielson, EI; Walker, AE1
Eisenhofer, G; Huebner, A; Mangelis, A; Peitzsch, M1
Bůžková, P; Carbone, LD; Coughlin, SS; Fink, HA; Isales, CM; Le, B; Raiford, M; Robbins, JA; Shikany, JM1
Ari, N; Aydin, E; Cumaoğlu, A; Dilsiz, N; Karasu, C; Sakul, A1
Jeon, JH; Jeong, E; Kim, HC; Kim, IB; Park, YJ; Sim, S; Yang, MJ1
Iida, A; Miyauchi, H; Muramatsu, S; Shimazaki, K; Takino, N1
Bai, L; Ding, J; Gao, J; Gu, M; Marshall, C; Miao, D; Shen, L; Wu, T; Xiao, M1
Baltanás, A; Fortuño, A; Galindo, MF; Jordán, J; Solesio, ME; Zalba, G1
Brewer, LD; Butterfield, DA; Cai, J; Förster, S; Keeney, JTR; Klein, JB; Latimer, CS; Porter, NM; Sultana, R1
Dedola, GL; Farina, V; Giua, S; Lepore, G; Mura, E; Zedda, M1
Han, L; Li, MG; Ye, P1
Chen, L; Cheng, S; Fan, Q; Lau, WB; Li, F; Liu, JH; Wang, le F1
Bramwell, RC; Donato, AJ; Enz, RA; Hart, CR; Hazra, S; Henson, GD; Layec, G; Lesniewski, LA; Morgan, RG; Reihl, KD; Richardson, RS; Trinity, JD; Walker, AE1
Böhmová, A; Kačer, P; Kuzma, M; Mikoška, M; Pelclová, D; Syslová, K1
Kim, SH; Lee, JH; Park, JY; Park, S1
Jackson, MJ; McArdle, A; Pearson, T1
Cawston, TE; Hui, W; Proctor, CJ; Rowan, AD; Xu, X; Young, DA1
Kuwahira, I; Nagai, H; Nara, A; Ogura, S; Shimosawa, T; Shintani-Ishida, K; Shirai, M; Yoshida, K1
Alves, R; Andreotti, DZ; Böhmer, AE; de Sá Lima, L; Kawamoto, EM; Kinoshita, PF; Marcourakis, T; Marques Orellana, AM; Scavone, C; Vasconcelos, AR; Yshii, LM1
Biswal, S; Chen, H; Guo, J; Jin, S; Kombairaju, P; Zirkin, BR1
Calabrese, EJ; Calabrese, V; Dattilo, S; Ferreri, T; Graziano, A; Koverech, G; Maiolino, L; Monte, I; Parenti, R; Pennisi, M; Petralia, A1
Baur, JA; Becker, LB; Bhatti, T; Guan, Y; Karamercan, MA; Sims, CA; Wang, H; Ye, L1
Chun, Y; Kim, CS; Kim, HJ; Kim, J; Park, S; Song, W1
Hirobe, T; Ishikawa, A1
Fisher, AL; Ipson, BR1
Bloch, W; Labbé, D; Michel, O; Schick, B1
Ban, TH; Chang, YS; Choi, BS; Jang, IA; Kim, EN; Kim, MY; Lim, JH; Park, CW; Shin, SJ; Yoon, HE1
Barbosa, RM; Dias, C; Ferreiro, E; Laranjinha, J; Ledo, A; Lourenço, CF1
Butterfield, DA; Ceddia, MA; Farr, SA; Feng, S; Herrlinger, KA; Lewis, BJ; Morley, JE; Niehoff, ML; Welleford, A1
Del Moral, ML; Molina, F; Peinado, MÁ; Rus, A1
Chakravarti, B; Chakravarti, DN1
Collier, TJ; Kanaan, NM; Kordower, JH1
Babusikova, E; Dobrota, D; Jesenak, M; Kaplan, P; Racay, P1
Chen, CN; Ferrington, DA; Thompson, LV1
Alway, SE; Pistilli, EE; Siu, PM1
Cha, CI; Cho, YW; Huh, Y; Lee, JJ; Yeo, SG1
Carter, R; Gay, L; Geor, R; Treiber, K; Williams, C1
Anderson, MC; Connell, ML; Donato, AJ; Durrant, JR; Folian, BJ; Lesniewski, LA; Seals, DR1
Beske, SD; Lawson, BR; Lesniewski, LA; Pierce, GL; Seals, DR1
Boveris, A; Cadenas, E; Hamilton, RT; Lam, PY; Yin, F1
Auten, KM; Auten, RL; Brahmajothi, M; Mason, SN1
Connell, ML; Donato, AJ; Durrant, JR; Folian, BJ; Lawson, BR; Lesniewski, LA; Russell, MJ; Seals, DR1
Cho, JH; Choi, JH; Hwang, IK; Lee, CH; Lee, YL; Park, CW; Park, OK; Shin, HC; Won, MH; Yoo, KY1
Kang, LS; Muller-Delp, JM; Reyes, RA1
Denvir, MA; Gray, GA1
Huang, A; Kaley, G; Sun, D; Yang, YM1
Bordin, L; Bragadin, M; Brunati, AM; Clari, G; Fiore, C1
Chen, L; Feany, MB; Hyman, BT; McLean, PJ; Negro, A; Periquet, M; Wang, X1
Anniko, M; Hamamoto, T; Hirakawa, K; Ishibashi, T; Takumida, M1
Gonzalez, L; Jiang, L; Ke, Z; Li, C; Li, W; Liu, Y; Yang, G; You, J; Yu, X; Yu, Y1
Del Priore, LV; Dillon, J; Gaillard, ER; Murdaugh, LS; Wang, Z1
Elfering, S; Fujisawa, Y; Giulivi, C; Haynes, V; Traaseth, NJ1
Holowatz, LA; Kenney, WL; Lang, JA1
Amaning, JK; Bailey, CE; DeFord, JH; Dimayuga, VL; Nuss, JE; Papaconstantinou, J; Rabek, JP1
Betik, AC; Hepple, RT; Thomas, MM; Tupling, AR; Vigna, C1
Huh, Y; Hwang, SJ1
Cha, HN; Kim, JY; Kim, YD; Kim, YW; Min, KN; Park, SY; Song, IH1
Baker, SL; Braskie, MN; Jagust, WJ; Landau, SM; Madison, CM; O'Neil, JP; Taylor, SD; Wilcox, CE1
Folkmann, JK; Jacobsen, NR; Loft, S; Møller, P; Sheykhzade, M; Vesterdal, LK; Wallin, H1
Evers, BM; Saito, H; Starr, ME; Ueda, J; Yamamoto, S1
Brunk, UT; Dunlop, RA; Rodgers, KJ1
Connell, ML; Donato, AJ; Durrant, JR; Folian, BJ; Lesniewski, LA; Seals, DR1
Jackson, MJ; Kabayo, T; McArdle, A; McArdle, F; Palomero, J; Pye, D; Richardson, A; Sakellariou, GK; Tidball, JG; Van Remmen, H; Vasilaki, A; Zibrik, L1
Bergantin, LB; Figueiredo, LB; Godinho, RO1
Donato, AJ; Eskurza, I; LaRocca, TJ; Pierce, GL; Seals, DR; Silver, AE1
Baylis, C; Moningka, NC; Muller-Delp, JM; Sindler, AL1
Amaning, JK; Bailey, CE; Deford, JH; Dimayuga, VL; Farrar, R; Hammers, DW; Papaconstantinou, J1
Bruno, MA; Cuello, AC1
Boirie, Y; Guillet, C; Migné, C; Murakami, H; Salles, J; Tardif, N; Walrand, S1
de Lange, A; Gijsen, AP; Groen, B; Pennings, B; Senden, JM; van Loon, LJ; Zorenc, AH1
Feeney, MB; Schöneich, C1
Aksenov, V; Liu, J; Long, J; Rollo, CD1
Bridenbaugh, EA; Gashev, AA; Thangaswamy, S1
Dodson, RB; Eng, JS; Fleenor, BS; Nair, DP; Seals, DR; Sindler, AL1
Dussault, S; Groleau, J; Haddad, P; Maingrette, F; Perez, G; Rivard, A; Turgeon, J1
Davidge, ST; Jiang, Y; Lekontseva, O; Schleppe, C1
Ammassari-Teule, M; Barbagallo, AP; Biundo, F; Canu, N; D'Adamio, L; La Rosa, LR; Lombino, F; Luvisetto, S; Matrone, C; Pignataro, A; Tamayev, R; Yang, L; Zheng, H1
Fleenor, BS; Howell, KL; Marvi, NK; Seals, DR; Sindler, AL; Yoshizawa, M; Zigler, ML1
Chakravarti, B; Chakravarti, DN; Lutfeali, R; Marshall, A; Raval, A1
Brink, PR; Glass, PS; Liu, L; Rebecchi, MJ; Wang, Q; Zhu, J1
Vaziri, ND; Wang, HW; Wang, XQ; Zhang, J; Zhou, XJ1
Cha, CI; Chung, YH; Joo, KM; Kim, MJ; Shin, CM1
Carlson, CS; Cole, A; Del Carlo, M; Loeser, RF1
Ferrington, DA; Kapphahn, RJ; Louie, JL1
Bondy, SC; Ni, Z; Sharman, EH; Sharman, KG; Vaziri, ND1
Abdel-Mageed, AB; Armstrong, JS; Biggerstaff, J; Bivalacqua, TJ; Champion, HC; Hellstrom, WJ; Kadowitz, PJ1
Akçay, T; Cakatay, U; Kayali, R; Sivas, A; Tekeli, F; Telci, A2
Curfs, JH; Kuijpers, W; Peters, TA; Tonnaer, EL1
Abdalla Saad, MJ; Alvarez-Rojas, F; Carvalheira, JB; Carvalho, CR; Dolnikoff, MS; Hirata, AE1
Debrabander, A; Dobbelaere, D; Farriaux, JP; Gottrand, F; Michaud, L; Turck, D; Vanderbecken, S1
WALIGORA, Z; WENDER, M1
MARSDEN, CD1
LABELLA, FS2
KNOX, WE; LINDER, MC; LYNCH, RD; MOORE, CL1
STEVEN, FS1
Blomberg, BB; Riley, RL; Sherwood, EM; Van der Put, E1
Aydar, Y; Balogh, P; Szakal, AK; Tew, JG1
Arenas, IA; Armstrong, SJ; Davidge, ST; Pehowich, DJ; Xu, Y1
Lindquist, M; Ponnappan, S; Ponnappan, U; Uken-Trebilcock, G1
de Cabo, R; Ingram, DK; Lane, MA; Zhu, M1
Banks, WA; Butterfield, DA; Calabrese, V; Farr, SA; Joshi, G; Morley, JE; Poon, HF; Sultana, R1
Behring, A; Kanski, J; Pelling, J; Schöneich, C1
Beitzel, F; Lynch, GS; Plant, DR; Ryall, JG; Schertzer, JD; Stupka, N1
Bachschmid, M; Cosentino, F; delli Gatti, C; Francia, P; Lüscher, TF; Martin-Padura, I; Migliaccio, E; Pelicci, PG; Savoia, C; Schiavoni, M; Volpe, M1
Bahr, BA; Blomgren, K; Hagberg, H; Shibata, M; Uchiyama, Y; Wang, X; Xu, F; Zhu, C1
Barreca, A; Johansen, T; Laurino, C; Malmlöf, K1
Chung, HY; Lee, J; Son, TG; Yu, BP; Zou, Y1
Hong, SJ; Kanski, J; Schöneich, C1
Love, PE; Mathis, MA; Pitcher, LA; Subramanian, S; van Oers, NS; Wakeland, EK; Young, JA1
Aerni, A; Coluccia, D; de Quervain, DJ; Garcia, E; Henke, K; Hock, C; Huynh, KD; Monsch, AU; Nitsch, RM; Papassotiropoulos, A; Stähelin, HB; Wollmer, MA1
Cui, L; Hutton, ML; Lee, G; Propst, JA; Vega, IE; Yen, SH1
Bardsley, V; Fellows, IW; Jennings, BA; Lonsdale, R; Willis, G; Wimperis, JZ1
Dremina, ES; Schöneich, C; Sharov, VS1
Janik, B; Makarewicz, D; Zalewska, T; Ziemka-Nałecz, M1
Bondy, CA; Cheng, CM; Matyakhina, L; Tseng, V; Wang, D; Wang, J1
Bigelow, DJ; Knyushko, TV; Schöneich, C; Sharov, VS; Williams, TD1
Dixit, V; Guo, X; Henderson, GN; James, MO; Liu, H; Shroads, AL; Stacpoole, PW1
Adachi, T; Bigelow, D; Cohen, RA; Guo, W; Jiang, B; Knyushko, TV; Lazar, H; Menzoian, J; Schöneich, C; Sharov, V; Xu, S; Ying, J1
Bachschmid, M; Hahn, R; Kilo, J; Labugger, R; Lüscher, TF; Palacios-Callender, M; Schildknecht, S; van der Loo, B1
Douziech, N; Fortin, CF; Fulop, T; Larbi, A; Lesur, O1
Doser, TA; Fang, CX; Janardhanan, R; Nunn, JM; Quinn, MT; Ren, J; Sreejayan, N; Yang, X; Zhu, M1
Galeva, NA; Kanski, J; Schöneich, C; Sharov, VS; Williams, TD1
Anantharaman, M; Keller, JN; Kiningham, KK; Markesbery, WR; Murphy, MP; St Clair, DK; Tangpong, J1
Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A; Rigual, R1
Ferrington, DA; Fugere, NA; Thompson, LV1
Jiang, H; Schacht, J; Sha, SH; Talaska, AE1
Gijsen, AP; Gorselink, M; Koopman, R; Manders, RJ; Pijpers, E; van Loon, LJ; Verdijk, L; Wagenmakers, AJ1
Schöneich, C1
Benito, M; Clampit, JE; Escribano, O; Gonzalez-Rodriguez, A; Rondinone, CM; Valverde, AM1
Beller, CJ; Berger, I; Chen, SH; Gero, D; Groves, JT; Lin, LN; Radovits, T; Seres, L; Szabó, C; Szabó, G; Zotkina, J1
Cristòfol, R; García-Matas, S; Pertusa, M; Rodríguez-Farré, E; Sanfeliu, C1
Gokulrangan, G; Michaelis, ML; Schöneich, C; Zaidi, A1
Barlow, PN; Blaum, BS; Deakin, JA; Egan, C; Ferreira, VP; Herbert, AP; Lyon, M; Pangburn, MK; Schmidt, CQ; Uhrín, D1
Berger, I; Gero, D; Karck, M; Radovits, T; Seres, L; Szabó, C; Szabó, G1
Fritsche, L; Hartmann, A; Heinen, S; Keilhauer, CN; Lauer, N; Schlötzer-Schrehardt, U; Skerka, C; Smith, R; Sühnel, J; Weber, BH; Weinberger, AA; Zipfel, PF1
Donato, AJ; Eskurza, I; Gates, PE; Levy, AS; Pierce, GL; Seals, DR; Silver, AE1
Besshoh, S; Brown, IR; Chen, S; Gurd, JW1
Blanco, S; Castro, L; Del Moral, ML; Hernández, R; Martínez-Lara, E; Pedrosa, JA; Peinado, MA; Siles, E1
Bellucci, A; Casamenti, F; Fiorentini, A; Grossi, C; Luccarini, I; Rosi, MC1
Asano, S; Blough, ER; Desai, DH; Kakarla, S; Katta, A; Rice, KM; Walker, EM; Wehner, P1
Cakatay, U; Genç, H; Kayali, R; Uzun, H1
DeRuisseau, KC; DeRuisseau, LR; Jung, SH; Kavazis, AN1
He, J; Li, X; Li, XM; Luo, H; Tempier, A; Wang, H; Wei, Z; Xu, H; Yan, B; Yu, Y; Zhang, Y1
Bigelow, DJ1
Fisher, AL; Lithgow, GJ; Nash, L; Page, KE1
Barbieri, M; Crescenzi, B; D'Amico, M; Di Filippo, C; Ferraraccio, F; Laieta, MT; Marfella, R; Paolisso, G; Rossi, F; Sangiulo, P; Vestini, R1
Kregel, KC; Oberley, TD; Swanlund, JM; Zhang, HJ1
Zhinkin, LN1
Dickson, IR; Happey, F; Naylor, A; Pearson, CH; Turner, RL1
Greenland, RD; Lasley, SM; Michaelson, IA; Minnema, DJ1
Chandra, SV; Dubey, MP; Shukla, GS1
Marchington, DR; Shargill, NS; York, DA1
Heishman, SJ; Thurmond, JB1
Dickens, G; Guroff, G; Ikeno, T; Lloyd, T1
Gregg, VA; Milligan, LP1
Iriyama, K; Itoh, K; Iwamoto, T; Mizuno, A; Ozaki, Y; Yoshiura, M1
Hedner, T; Lundborg, P1
Schneider, AJ1
Fish, I; Hochgeschwender, U; Samuels, S; Schwartz, SA1
Bates, PC; Crie, JS; Griffin, EE; Millward, DJ; Wildenthal, K1
Cooper, RL; Linnoila, M2
Porter, JC; Reymond, MJ1
Arce, CA; Barra, HS; Caputto, R1
Ding, A; Hwang, S; Schwab, R1
Chua-Couzens, J; Clary, DO; Holtzman, DM; Kaplan, DR; Knüsel, B; Kromer, LF; Li, Y; Mobley, WC1
Aguirre, J; Armando, I; Barontini, M; Nowicki, S1
Gilliland, LK; Grossmann, A; Jinneman, JC; Kanner, SB; Kavanagh, TJ; Ledbetter, JA; Rabinovitch, PS1
Iwase, T; Kino, I; Naito, Y; Sugimura, H; Suzuki, M; Tanaka, M1
Polk, DB1
Balasubramanian, D; Luthra, M; Ranganathan, D; Ranganathan, S1
Cybulsky, AV; Goodyer, PR; McTavish, AJ1
Miller, RA; Shi, J2
Arola, LI; Salvadó, MJ1
Kamei, A1
Bobek, P; Krajcovicová-Kudlácková, M; Ozdín, L1
Greve, J; Otto, K; Puppels, GJ; Smeets, MH; Vrensen, GF1
Kee, AJ; Smith, RC1
Poddar, R; Sarkar, PK1
Majumdar, AP; Wahby, M1
Baynes, JW; Dyer, DG; Huggins, TG; Thorpe, SR; Wells-Knecht, MC1
Faull, KF; Fisher, RS; Fluharty, AL; Gayek, RJ; Lazareff, JA; Olmstead, CE; Orlino, EN; Peacock, WJ; Wehby-Grant, MC1
Majumdar, AP; Malecka-Panas, E; Relan, NK1
Bigelow, DJ; Ferrington, DA; Hühmer, AF; Schöneich, C; Viner, RI1
Cano, J; de la Cruz, CP; Machado, A; Revilla, E; Rodríguez-Gómez, JA; Steffen, V1
Harris, N; Milakofsky, L; Vogel, WH1
Chevalier, B; Duclos, MJ; Goddard, C; Remignon, H; Ricard, FH; Simon, J1
Garcia, GG; Miller, RA2
Chao, CC; Ma, YS; Stadtman, ER1
Ahlrichs, JA; Denne, SC; Karn, CA; Leitch, CA; Liechty, EA; Poindexter, BB; Wang, J1
Arnold, LA; Bebin, EM; Fryburg, JS; Gunasekera, RS; Hyland, K; Jacobson, RD; Rost-Ruffner, E; Trugman, JM; Wilson, WG1
Chan, VW; DeFranco, AL; Lowell, CA; Meng, F; Soriano, P1
Dewhirst, MW; Greenberg, CS; Haroon, ZA; Peters, KG; Werner, S; Wong, AL1
Heinecke, JW; Holloszy, JO; Leeuwenburgh, C; Sohal, RS; Wagner, P1
Hansen, P; Heinecke, JW; Holloszy, JO; Leeuwenburgh, C; Shaish, A1
Harris, MD; Pahlavani, MA; Richardson, A1
Gao, J; Squier, TC; Williams, TD; Yao, Y; Yin, D1
Lipschitz, D; Ponnappan, U; Tinkle, CW1
Abraham, GN; Chakravarti, B; Chakravarti, DN; Devecis, J; Seshi, B1
Babst, R; Bongiorno, L; Marini, M; Marzano, M; Roda, LG; Spagnoli, G; Urbani, A1
Dunah, AW; Wolfe, BB; Yasuda, RP1
Alonso, D; Barroso, JB; Bentura, ML; Campbell, RO; Esteban, FJ; Fernández, AP; Leza, JC; Lizasoain, I; Martínez-Murillo, R; Moro, MA; Pedrosa, JA; Peinado, MA; Richart, A; Rodrigo, J; Santacana, M; Serrano, J; Uttenthal, LO; Valderrama, R1
Hashizume, Y; Kato, Y; Maruyama, W; Naoi, M; Osawa, T1
Hansen, PA; Heinecke, JW; Holloszy, JO; Leeuwenburgh, C1
Bignami, F; Camus, G; Cartaud, A; Cartaud, J; Ludosky, MA; Marchand, S1
Palmer, HJ; Paulson, KE; Tuzon, CT1
Bigelow, DJ; Ferrington, DA; Schöneich, C; Viner, RI; Williams, TD1
Arcand, M; Desgeorges, S; Dupuis, G; Fülöp, T; Gagné, D; Goulet, AC; Lacombe, G1
Anthony, M; Honse, Y; Qiao, G; Sun, L; Willis, R1
Chen, M; Liu, B; Newhouse, YG; Whisler, RL1
Li, M; Sierra, F; Torres, C; Walter, R1
Brenelli, SL; Carvalho, CR; Maeda, L; Saad, MJ1
Ando, K; Beppu, M; Hayakawa, M; Hiramoto, K; Kikugawa, K; Nakauchi, K1
Saha, S; Slepecky, NB1
Abe, T; Ishizaki, E; Isobe, C; Murata, T; Tohgi, H; Yamazaki, K1
Fernstrom, JD1
Carvalho, E; Rondinone, C; Smith, U1
Berry, SA; Frick, GP; Goodman, HM; Gruppuso, PA; Phornphutkul, C1
Dejesus, OT; Endres, CJ; Holden, JE; Nickles, RJ; Shelton, SE1
Bachschmid, M; Erusalimsky, JD; Gygi, D; Kilo, J; Labugger, R; Lüscher, TF; Malinski, T; Palacios-Callender, M; Powell, JM; Quaschning, T; Skepper, JN; Ullrich, V; van der Loo, B1
Bickford, PC; Kaufmann, JA; Taglialatela, G1
Ferrini, M; González-Cadavid, NF; Magee, TR; Rajfer, J; Vernet, D1
De Boever, J; De Creus, A; Debacker, V; Leclercq, G; Plum, J; Stevenaert, F; Van Beneden, K1
Boland, R; de Boland, AR; Gentili, C1
Kawano, H; Matsushita, H; Ochi, M; Sakai, H; Takeuchi, Y1
Ferrini, M; Gonzalez-Cadavid, NF; Rajfer, J; Sinha Hikim, AP; Swerdloff, RS; Wang, C1
Duff, K; La Francois, J; Matsuoka, Y; Picciano, M1
Davies, SM; Duncan, MW; Murphy, MP; Poljak, A; Smythe, GA1
Desgeorges, S; Douziech, N; Dupuis, G; Fülöp, T; Goulet, AC; Lacombe, G; Linteau, A1
Ali, SF; Imam, SZ1
Bendinelli, P; Maroni, P; Piccoletti, R; Schiaffonati, L; Tiberio, L1
Ariga, K; Myoui, A; Nakase, T; Okuda, S; Yonenobu, K; Yoshikawa, H1
Dillon, J; Galicia, E; Paik, DC; Tilson, MD1
Baskerville, KA; Bryan, D; Gallagher, M; Gonzalez, J; Lund, K; McKinney, M; Nicolle, MM; Sugaya, K1
Abraham, GN; Chakravarti, B1
Eckert, A; Fröhlich, L; Maurer, K; Müller, WE; Schindowski, K1
Stadtman, ER1
De, CR; Landolfi, R; Marchioli, R; Rocca, B1
Cha, CI; Chung, YH; Kim, EG; Kim, MJ; Lee, EY; Shin, CM1
Drew, B; Leeuwenburgh, C1
Courtois, Y; Goureau, O; Sennlaub, F1
Dong, LQ; Guo, Z; Lim, MA; Liu, F; Ramos, FJ; Richardson, A; Strong, R; Wick, MJ1
Csiszar, A; Edwards, JG; Kaley, G; Kaminski, P; Koller, A; Ungvari, Z; Wolin, MS1
Hosbach, HA; Kubli, E1
Khvisiuk, NI; Timoshenko, OP1
Ledvina, M; Malaník, V1
Sandberg, LB1
Adelman, RC; Roth, GS1
Benignus, VA; Davis, JN; McNamara, MC; Miller, AT1
Barr-Nea, L; Wolman, M1
Gemant, A1
Dunlop, D; Lajtha, A; Patlak, C; Toth, J1
Bertolini, AM; Santagostino, A1
Berry, HK; Butcher, RE; Kazmaier-Novak, KJ; Kindt, CW; Vorhees, CV1
Algeri, S; Brunello, N; Ponzio, F1
Borisy, GG; Rodriguez, JA1
Daniel, PM; Moorhouse, SR; Pratt, OE1
Carlsson, A1
Bozcuk, AN1
Goldspink, DF; Goldspink, G1
Dobbing, J; Pickard, FJ; Tricklebank, MD1
Bondy, SC; Purdy, JL1
Alper, A; Dougher, GJ; Finch, CE; Hody, G; Jonec, V; Morton-Smith, W; Walker, JP1
Flavin, M; Raybin, D1
Finch, CE; Jonec, V1
Bayomi, RA; Smith, WR1
Cohen, O; Nadiv, O; Zick, Y1
Afonso, D; Arevalo, R; Rodriguez, M; Santana, C1
Ingram, RL; Lenham, JE; Sonntag, WE1
Baynes, JW; Detorie, NJ; Dyer, DG; Huggins, TG; Staton, MW; Thorpe, SR; Walla, MD1
Fligiel, SE; Hatfield, JS; Jasti, S; Majumdar, AP; Tureaud, J1
Abe, T; Takahashi, S1
Breckenridge, MB; Grants, IS; Liu, BQ; Newhouse, YG; Walters, JD; Whisler, RL1
Abbasi, AA; Chaudry, F; Mattson, DE; Rudman, D1
Clavel, MC; Faivre-Sarrailh, C; Rabié, A1
Cheng, N; Sahyoun, N1
Bassant, MH; Godefroy, F; Lamour, Y; Sarhan, H; Weil-Fugazza, J1
Chen, TS; Currier, GJ; Wabner, CL1
Geesin, JC; Gordon, JS; Gracy, RW; Jacobson, TM; Lane, AT; Yüksel, KU1
Tillotson, ML; Wood, JG1
Haworth, SG; Polak, JM; Wharton, J1
Alonso, AC; Arce, CA; Barra, HS1
Goto, S; Takahashi, R1
Barron, BC; Kuck, JF; Yu, NT1
Navab, F; Winter, CG1
Aragon, MC; Diez-Guerra, J; Gimenez, C; Herrero, E; Valdivieso, F1
Bessems, GJ; Hoenders, HJ1
Semensi, V; Sugumaran, M1
Kochel, RL; Lloyd, T; Weinstein, JM1
Kraus, H1
Davey, KG; Huebner, E; Tobe, SS1
Anderson, TJ; Ewen, SW1
Gutmann, E; Hájek, I; Syrový, I2
Angelakos, ET; Bajusz, E; Carballo, LC; Daniels, JB; King, MP1
Jakubiec-Puka, A; Mochnacka, I1
Behrman, RE; Fellman, JH; Jones, RT; Koler, RD; Vanbellinghen, PJ1
Rauch, H; Siegel, SJ1
Benda, P; Bourgoin, S; Faivre-Bauman, A; Glowinski, J; Hamon, M1
Deyl, Z; Vanćiková, O1
Franklin, EC; Rosenthal, CJ1
de Jong, W; Provoost, AP; van Ree, JM; Versteeg, DH1
Hornykiewicz, O; Lloyd, KG1
Finch, CE1
Bemiller, JN; Hoffmann, WE; Pappelis, AJ1
Arcce, CA; Barra, HS; Caputto, R; Rodriguez, JA1
Copius Peereboom, JW1
Geison, RL; Josephson, L1
De Luca, F; Macaione, S; Ruggeri, P; Tucci, G1
Ilan, J1
Pomerantz, SH1
Dapson, RW; Irland, JM1
Phillips, J; Sager, R; Tocci, PM1
Murayama, K1
Burzynski, NJ1
Graeber, W1
Horecker, BL; Koida, M; Lai, CY1
Peereboom, JW1
Ignarro, LJ; Shideman, FE1
Mauldin, JK; Mitlin, N; Wiygul, G1
Clarke, JT; Lowden, JA1
Berman, MD; Kotula, AW1

Reviews

11 review(s) available for tyrosine and Aging

ArticleYear
Multimarker screening of oxidative stress in aging.
    Oxidative medicine and cellular longevity, 2014, Volume: 2014

    Topics: Aging; Biomarkers; Dinoprost; DNA Damage; Guanosine; Humans; Oxidative Stress; Proteins; Tyrosine

2014
Analytical approaches to the diagnosis and treatment of aging and aging-related disease: redox status and proteomics.
    Free radical research, 2015, Volume: 49, Issue:5

    Topics: Age Factors; Aging; Animals; Biomarkers; Disease Susceptibility; Glutathione; Humans; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Phenotype; Predictive Value of Tests; Protein Carbonylation; Proteins; Proteomics; Risk Factors; Tyrosine

2015
Roles of the tyrosine isomers meta-tyrosine and ortho-tyrosine in oxidative stress.
    Ageing research reviews, 2016, Volume: 27

    Topics: Aging; Animals; Biomarkers; Isomerism; Oxidative Stress; Tyrosine

2016
Protein Tyrosine Nitration: Role in Aging.
    Current aging science, 2017, Volume: 10, Issue:4

    Topics: Age Factors; Aging; Animals; Brain; Humans; Liver; Myocardium; Nitrosative Stress; Oxidative Stress; Protein Conformation; Protein Processing, Post-Translational; Proteomics; Reactive Nitrogen Species; Reactive Oxygen Species; Structure-Activity Relationship; Tyrosine

2017
Tyrosine modifications in aging.
    Antioxidants & redox signaling, 2012, Dec-01, Volume: 17, Issue:11

    Topics: Aging; Atherosclerosis; Cataract; Humans; Nerve Degeneration; Oxidative Stress; Protein Processing, Post-Translational; Proteins; Structure-Activity Relationship; Tyrosine

2012
Protein modification in aging: an update.
    Experimental gerontology, 2006, Volume: 41, Issue:9

    Topics: Aging; Histidine; Humans; Lamin Type A; Neurodegenerative Diseases; Nuclear Proteins; Oxidation-Reduction; Progeria; Protein Precursors; Protein Processing, Post-Translational; Pyruvaldehyde; Transglutaminases; Tyrosine

2006
Nitrotyrosine-modified SERCA2: a cellular sensor of reactive nitrogen species.
    Pflugers Archiv : European journal of physiology, 2009, Volume: 457, Issue:3

    Topics: Aging; Animals; Biosensing Techniques; Energy Metabolism; Humans; Models, Molecular; Muscles; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Reactive Nitrogen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine

2009
Can nutrient supplements modify brain function?
    The American journal of clinical nutrition, 2000, Volume: 71, Issue:6 Suppl

    Topics: Aging; Animals; Brain; Diet; Dietary Supplements; Fatty Acids, Unsaturated; Folic Acid; Hematinics; Humans; Nutritional Physiological Phenomena; Tryptophan; Tyrosine

2000
Protein oxidation in aging and age-related diseases.
    Annals of the New York Academy of Sciences, 2001, Volume: 928

    Topics: Aging; Amino Acids; Animals; Antioxidants; Apoptosis; Cross-Linking Reagents; Cysteine; Disease; Humans; Longevity; Methionine; Models, Biological; Nitric Oxide; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptides; Peroxynitrous Acid; Protein Denaturation; Proteins; Rats; Reactive Oxygen Species; Tyrosine

2001
Aging and the role of reactive nitrogen species.
    Annals of the New York Academy of Sciences, 2002, Volume: 959

    Topics: Aging; Animals; Diet; Humans; Molecular Structure; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteins; Reactive Nitrogen Species; Tyrosine

2002
Elastin structure in health and disease.
    International review of connective tissue research, 1976, Volume: 7

    Topics: Aging; Amino Acid Sequence; Amino Acids; Animals; Arteriosclerosis; Calcium; Cholesterol; Copper; Cyanogen Bromide; Desmosine; Diet; Elastin; Microbial Collagenase; Models, Chemical; Molecular Weight; Protein Conformation; Swine; Tyrosine

1976

Trials

6 trial(s) available for tyrosine and Aging

ArticleYear
Oral L-Tyrosine Supplementation Improves Core Temperature Maintenance in Older Adults.
    Medicine and science in sports and exercise, 2020, Volume: 52, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Body Temperature Regulation; Cold Temperature; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Skin; Skin Temperature; Tyrosine; Vasoconstriction; Young Adult

2020
Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging.
    Nutrients, 2017, Nov-23, Volume: 9, Issue:12

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aging; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Tyrosine; Young Adult

2017
Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.
    Circulation, 2009, Mar-10, Volume: 119, Issue:9

    Topics: Administration, Oral; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Endothelium, Vascular; Female; Humans; I-kappa B Proteins; Male; Middle Aged; NADPH Oxidases; NF-kappa B; NF-KappaB Inhibitor alpha; Obesity; Overweight; Oxidative Stress; Salicylates; Tyrosine; Vasodilation

2009
Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men.
    American journal of physiology. Endocrinology and metabolism, 2012, Apr-15, Volume: 302, Issue:8

    Topics: Aged; Aging; Algorithms; Amino Acids; Blood Glucose; Carbon Isotopes; Deuterium; Digestion; Humans; Insulin; Intestinal Absorption; Kinetics; Male; Milk Proteins; Muscle Proteins; Oxidation-Reduction; Phenylalanine; Postprandial Period; Quadriceps Muscle; Tyrosine; Whey Proteins

2012
Evaluation of nutritional status and pathophysiology of growth retardation in patients with phenylketonuria.
    Journal of inherited metabolic disease, 2003, Volume: 26, Issue:1

    Topics: Aging; Anthropometry; Body Composition; Body Height; Body Weight; Child; Child, Preschool; Chromatography, Gas; Cross-Sectional Studies; Diet; Erythrocytes; Female; Growth Disorders; Hormones; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Nutritional Status; Phenylalanine; Phenylketonurias; Thyroid Hormones; Trace Elements; Tyrosine

2003
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.
    The American journal of clinical nutrition, 2006, Volume: 84, Issue:3

    Topics: Activities of Daily Living; Adult; Aged; Aging; Carbon Isotopes; Cross-Over Studies; Dietary Carbohydrates; Dietary Proteins; Double-Blind Method; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Tyrosine

2006

Other Studies

328 other study(ies) available for tyrosine and Aging

ArticleYear
Whey protein concentrate protects against age-dependent alteration in redox biomarkers.
    Biologia futura, 2020, Volume: 71, Issue:3

    Topics: Aging; Animals; Biomarkers; Cysteine; Drug Evaluation, Preclinical; Erythrocytes; Glycation End Products, Advanced; Lipid Metabolism; Male; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; Tryptophan; Tyrosine; Whey Proteins

2020
Alterations in epididymal sperm maturation caused by ageing.
    Reproduction, fertility, and development, 2021, Volume: 33, Issue:18

    Topics: Aging; Animals; Epididymis; Male; Phosphorylation; Rats; Rats, Wistar; Sperm Maturation; Spermatozoa; Testosterone; Tyrosine

2021
Identification of a hippocampal lncRNA-regulating network in a natural aging rat model.
    BMC neuroscience, 2022, 09-28, Volume: 23, Issue:1

    Topics: Aging; Animals; Gene Regulatory Networks; Hippocampus; MicroRNAs; Peroxisome Proliferator-Activated Receptors; Rats; Reproducibility of Results; RNA, Long Noncoding; RNA, Messenger; Tumor Suppressor Protein p53; Tyrosine

2022
Egg white consumption increases GSH and lowers oxidative damage in 110-week-old geriatric mice hearts.
    The Journal of nutritional biochemistry, 2020, Volume: 76

    Topics: Aging; Aldehydes; Amino Acids, Sulfur; Animal Feed; Animals; Antioxidants; Egg White; Glutathione; Glutathione Synthase; Inflammation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress; Tyrosine

2020
Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis.
    Fukushima journal of medical science, 2019, Volume: 65, Issue:3

    Topics: Aging; Animals; Antigens, Neoplasm; Atherosclerosis; Disease Models, Animal; Female; Gene Knockdown Techniques; Glycation End Products, Advanced; Humans; Hyperlipidemias; Immunohistochemistry; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Plaque, Atherosclerotic; Rabbits; Receptor for Advanced Glycation End Products; Tyrosine

2019
Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.
    The Journal of nutrition, 2020, 05-01, Volume: 150, Issue:5

    Topics: Aged; Aging; Amino Acids; Body Weight; China; Dietary Proteins; Energy Intake; Energy Metabolism; Female; Humans; Male; Nutritional Requirements; Oxidation-Reduction; Phenylalanine; Recommended Dietary Allowances; Tyrosine

2020
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
    Hypertension (Dallas, Tex. : 1979), 2020, Volume: 76, Issue:1

    Topics: Acetylcholine; Adolescent; Adult; Aged; Aging; Animals; Antioxidants; Ascorbic Acid; Brachial Artery; Carotid Arteries; Cyclic N-Oxides; Dietary Supplements; Endothelium, Vascular; Gastrointestinal Microbiome; Humans; Methylamines; Mice; Mice, Inbred C57BL; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Spin Labels; Superoxides; Tyrosine; Vasodilation; Young Adult

2020
Receptor tyrosine kinases-instructed release of its inhibitor from hydrogel to delay ovarian aging.
    Biomaterials, 2021, Volume: 269

    Topics: Aging; Amino Acid Sequence; Animals; Female; Humans; Hydrogels; Mice; Ovary; Peptide Fragments; Tyrosine

2021
Downregulation of the tyrosine degradation pathway extends
    eLife, 2020, 12-15, Volume: 9

    Topics: Aging; Animals; Drosophila melanogaster; Electron Transport Chain Complex Proteins; Longevity; Mitochondria; Tigecycline; Tyrosine; Tyrosine Transaminase

2020
Mitochondria exert age-divergent effects on recovery from spinal cord injury.
    Experimental neurology, 2021, Volume: 337

    Topics: 2,4-Dinitrophenol; Aging; Animals; Cell Survival; Disease Progression; Female; Mice; Mice, Inbred C57BL; Mitochondria; Neurodegenerative Diseases; Neurons; Oxidative Stress; Oxygen Consumption; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries; Tyrosine; Uncoupling Agents

2021
Employing metabolomic approaches to determine the influence of age on experimental autoimmune encephalomyelitis (EAE).
    Molecular immunology, 2021, Volume: 135

    Topics: Age Factors; Aging; Animals; Autoimmunity; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Unsaturated; Female; Interleukin-6; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; NADPH Oxidases; Risk Factors; Sphingolipids; Spinal Cord; Tryptophan; Tyrosine

2021
Sex and Age-Related Differences in Neuroinflammation and Apoptosis in
    International journal of molecular sciences, 2021, Jun-11, Volume: 22, Issue:12

    Topics: Aging; Animals; Apoptosis; Biomarkers; Caspase 3; Docosahexaenoic Acids; Ependymoglial Cells; Female; Inflammation; Male; Mice, Inbred BALB C; Microglia; NF-kappa B; Retina; Sex Characteristics; Tumor Necrosis Factor-alpha; Tyrosine

2021
Impaired activity of adherens junctions contributes to endothelial dilator dysfunction in ageing rat arteries.
    The Journal of physiology, 2017, 08-01, Volume: 595, Issue:15

    Topics: Acetylcholine; Adherens Junctions; Aging; Animals; Antigens, CD; Arteries; Benzodioxoles; Cadherins; Endothelial Cells; Male; Phosphorylation; Quinazolines; Rats, Inbred F344; src-Family Kinases; Tyrosine; Vasodilator Agents

2017
Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum.
    Biochemical and biophysical research communications, 2017, 11-25, Volume: 493, Issue:3

    Topics: Aging; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Glutathione; Hippocampus; Male; Metabolome; Prefrontal Cortex; Rats, Sprague-Dawley; Sphingolipids; Tandem Mass Spectrometry; Tyrosine

2017
Food for thought: association between dietary tyrosine and cognitive performance in younger and older adults.
    Psychological research, 2019, Volume: 83, Issue:6

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Cognition; Cross-Sectional Studies; Dietary Supplements; Executive Function; Female; Germany; Humans; Intelligence; Male; Memory, Episodic; Memory, Short-Term; Middle Aged; Tyrosine; Young Adult

2019
Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:9

    Topics: Aging; Animals; Chemokine CCL2; Endoplasmic Reticulum Stress; Fibrosis; Heart; Hydrogen Sulfide; Hydroxyproline; Interleukin-6; Male; Malondialdehyde; Myocardium; Physical Conditioning, Animal; Rats; Sulfides; Tyrosine

2018
Effects of estrogen and aging on synaptic morphology and distribution of phosphorylated Tyr1472 NR2B in the female rat hippocampus.
    Neurobiology of aging, 2019, Volume: 73

    Topics: Aging; Animals; CA1 Region, Hippocampal; Dendritic Spines; Estradiol; Female; Neuronal Plasticity; Ovariectomy; Phosphorylation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tyrosine

2019
The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age.
    Scientific reports, 2019, 02-27, Volume: 9, Issue:1

    Topics: Aging; Animals; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickness; Cell Proliferation; Diet, Western; Endothelial Cells; Fatty Acids; Male; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Oxidative Stress; Regional Blood Flow; Tyrosine

2019
Age-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: Particular importance for early infancy.
    Clinica chimica acta; international journal of clinical chemistry, 2019, Volume: 494

    Topics: Adolescent; Adrenal Gland Neoplasms; Aging; Blood Chemical Analysis; Catecholamines; Child; Child, Preschool; Chromatography, Liquid; Dopamine; Female; Humans; Infant; Infant, Newborn; Male; Metanephrine; Normetanephrine; Paraganglioma; Pheochromocytoma; Reference Values; Tandem Mass Spectrometry; Tyrosine

2019
The Association of Aromatic Amino Acids with Incident Hip Fracture, aBMD, and Body Composition from the Cardiovascular Health Study.
    Calcified tissue international, 2019, Volume: 105, Issue:2

    Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Aging; Amino Acids, Aromatic; Body Composition; Body Mass Index; Bone Density; Diet; Diet Surveys; Ethnicity; Female; Hip Fractures; Humans; Male; Multivariate Analysis; Osteoporosis; Phenylalanine; Risk; Tryptophan; Tyrosine

2019
Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: consequences of treatment with antioxidant pyridoindole.
    Experimental gerontology, 2013, Volume: 48, Issue:5

    Topics: Aging; Aldehydes; Animals; Antioxidants; Cerebral Cortex; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Heart Ventricles; Indoles; Kidney; Lens, Crystalline; Liver; Male; Oxidation-Reduction; Oxidative Stress; Proteins; Pyridines; Rats; Rats, Wistar; Tyrosine

2013
Mitral and tufted cells are potential cellular targets of nitration in the olfactory bulb of aged mice.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Aging; Animals; Biomarkers; Blotting, Western; Immunohistochemistry; Memory; Mice; Microscopy, Electron; Nitric Oxide; Olfactory Bulb; Oxidative Stress; Smell; Tyrosine

2013
Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.
    BioMed research international, 2013, Volume: 2013

    Topics: Aging; Animals; Brain; Dependovirus; Genetic Vectors; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Motor Neurons; Mutation; Neuroglia; Neurons; Promoter Regions, Genetic; Purkinje Cells; Spinal Cord; Substantia Nigra; Transduction, Genetic; Tyrosine

2013
Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Aging; Animals; Antioxidants; Apoptosis; Biomarkers; Blotting, Western; Brain; Flow Cytometry; Gene Expression; Glutathione; Heterozygote; Immunohistochemistry; In Situ Nick-End Labeling; Lipofuscin; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenotype; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine

2014
The senescence-accelerated mouse prone-8 (SAM-P8) oxidative stress is associated with upregulation of renal NADPH oxidase system.
    Journal of physiology and biochemistry, 2013, Volume: 69, Issue:4

    Topics: Aging; Animals; Gene Expression; Glutathione; Glutathione Disulfide; Kidney; Lipid Peroxidation; Male; Malondialdehyde; Membrane Glycoproteins; Mice; Mice, Transgenic; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; Tyrosine; Up-Regulation

2013
Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline.
    Free radical biology & medicine, 2013, Volume: 65

    Topics: Aging; Animals; Blotting, Western; Brain; Cognition Disorders; Diet; Disease Models, Animal; Isoelectric Focusing; Male; Mass Spectrometry; Nitrosation; Proteomics; Rats; Rats, Inbred F344; Tyrosine; Vitamin D Deficiency

2013
Brain aging and testosterone-induced neuroprotection: studies on cultured sheep cortical neurons.
    Neuro endocrinology letters, 2013, Volume: 34, Issue:5

    Topics: Aging; Animals; Cerebral Cortex; DNA Topoisomerases, Type II; DNA-Binding Proteins; Neurons; Neuroprotective Agents; Sheep; Testosterone; Tyrosine; Up-Regulation

2013
[The effect of PPARalpha signal channel on atorvastatin inhibiting MMP-9 expression in aging myocytes].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2013, Volume: 29, Issue:5

    Topics: Aging; Animals; Atorvastatin; Cells, Cultured; Heptanoic Acids; Matrix Metalloproteinase 9; Muscle Cells; Oxazoles; PPAR alpha; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Tyrosine

2013
Aging aggravates nitrate-mediated ROS/RNS changes.
    Oxidative medicine and cellular longevity, 2014, Volume: 2014

    Topics: Adult; Aged; Aging; Angina, Unstable; Animals; Aorta, Thoracic; Female; Glutathione; Humans; Isosorbide Dinitrate; Male; Malondialdehyde; Middle Aged; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine

2014
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction.
    The Journal of physiology, 2014, Sep-15, Volume: 592, Issue:18

    Topics: Adipose Tissue; Aging; Animals; Arteries; Body Weight; Carnitine; Glutamic Acid; Malates; Male; Mice; Mitochondria; Neovascularization, Physiologic; Oxidative Stress; Oxygen Consumption; Succinic Acid; Triglycerides; Tyrosine; Vasodilation

2014
Plasma levels of lysine, tyrosine, and valine during pregnancy are independent risk factors of insulin resistance and gestational diabetes.
    Metabolic syndrome and related disorders, 2015, Volume: 13, Issue:2

    Topics: Adult; Aging; Asian People; Blood Glucose; Blood Pressure; Diabetes, Gestational; Diet; Energy Intake; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Lysine; Pregnancy; Risk Factors; Tyrosine; Valine

2015
Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide.
    Free radical biology & medicine, 2015, Volume: 78

    Topics: Aging; Animals; Blotting, Western; Cells, Cultured; Cytosol; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitochondria; Mitochondria, Muscle; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide; Peroxiredoxins; Peroxynitrous Acid; Superoxides; Tyrosine

2015
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:2

    Topics: Activin Receptors, Type I; Aging; Animals; Cartilage, Articular; Collagen Type II; Computer Simulation; Extracellular Matrix; Immunohistochemistry; Interleukin-1; Knee Joint; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Oxidative Stress; Signal Transduction; Transforming Growth Factor beta; Tyrosine

2016
Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
    American journal of respiratory cell and molecular biology, 2015, Volume: 53, Issue:2

    Topics: Aging; Animals; Arginase; Cell Hypoxia; Enzyme Activation; Hypertension; Lung; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Pulmonary Artery; Rats, Sprague-Dawley; Tyrosine

2015
Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus.
    Neurobiology of aging, 2015, Volume: 36, Issue:5

    Topics: Aging; Animals; Fasting; Hippocampus; Lipopolysaccharides; Male; Neurodegenerative Diseases; Neurogenic Inflammation; Nitric Oxide; Nitric Oxide Synthase; Nucleotides, Cyclic; Oxidative Stress; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thiobarbiturates; Tyrosine

2015
Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells.
    Molecular and cellular endocrinology, 2015, Jul-05, Volume: 409

    Topics: Aging; Animals; Cells, Cultured; Humans; Leydig Cells; Male; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Testosterone; Tyrosine

2015
Resveratrol Rescues Kidney Mitochondrial Function Following Hemorrhagic Shock.
    Shock (Augusta, Ga.), 2015, Volume: 44, Issue:2

    Topics: Acute Kidney Injury; Aging; Aldehydes; Animals; Antioxidants; Citrate (si)-Synthase; Hemorrhage; Kidney; Male; Mitochondria; Oxidative Stress; Rats; Rats, Long-Evans; Reactive Oxygen Species; Resuscitation; Resveratrol; Shock, Hemorrhagic; Stilbenes; Tyrosine

2015
Treadmill Exercise Attenuates Retinal Oxidative Stress in Naturally-Aged Mice: An Immunohistochemical Study.
    International journal of molecular sciences, 2015, Sep-02, Volume: 16, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Deoxyguanosine; Lysine; Male; Mice; Oxidative Stress; Physical Conditioning, Animal; Retina; Tyrosine

2015
l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation.
    Journal of dermatological science, 2015, Volume: 80, Issue:3

    Topics: Aging; Albinism, Oculocutaneous; Animals; Cell Differentiation; Cell Proliferation; Intramolecular Oxidoreductases; Melanocytes; Membrane Glycoproteins; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Primary Cell Culture; RNA, Messenger; Tyrosine; Up-Regulation

2015
Hearing impairment, cochlear morphology, and peroxynitrite (ONOO(-)) formation in adult and aging NOS II knockout mice.
    Acta oto-laryngologica, 2016, Volume: 136, Issue:10

    Topics: Aging; Animals; Cochlea; Female; Hearing Loss; Immunohistochemistry; Mice, Knockout; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Tyrosine

2016
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aorta, Thoracic; Blotting, Western; Collagen Type IV; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Fibronectins; Immunohistochemistry; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin; Renin-Angiotensin System; Superoxide Dismutase; Transforming Growth Factor beta; Tyrosine

2016
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation.
    Neurobiology of aging, 2016, Volume: 46

    Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Hippocampus; Mice, Transgenic; Microelectrodes; Mitochondria; Neurotransmitter Agents; Nitric Oxide; Oxidative Phosphorylation; Oxygen Consumption; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tyrosine

2016
Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice.
    Physiology & behavior, 2016, 10-15, Volume: 165

    Topics: Abietanes; Aging; Aldehydes; Analysis of Variance; Animals; Cinnamates; Conditioning, Classical; Conditioning, Operant; Depsides; Dose-Response Relationship, Drug; Electroshock; Maze Learning; Mice; Mice, Mutant Strains; Oxidative Stress; Recognition, Psychology; Reinforcement, Psychology; Rosmarinic Acid; Rosmarinus; Triglycerides; Tyrosine

2016
Response of the Nitric Oxide System to Hypobaric Hypoxia in the Aged Striatum.
    Gerontology, 2017, Volume: 63, Issue:1

    Topics: Aging; Animals; Atmospheric Pressure; Corpus Striatum; Hypoxia, Brain; Immunohistochemistry; Male; Models, Neurological; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; RNA, Messenger; Tyrosine

2017
Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration.
    The European journal of neuroscience, 2008, Volume: 27, Issue:12

    Topics: Aging; Animals; Cytosol; Dopamine Plasma Membrane Transport Proteins; Fluorescent Antibody Technique; Immunohistochemistry; Macaca mulatta; Nerve Degeneration; Neurons; Substantia Nigra; Tyrosine; Ventral Tegmental Area; Vesicular Monoamine Transport Proteins

2008
Oxidative alternations in rat heart homogenate and mitochondria during ageing.
    General physiology and biophysics, 2008, Volume: 27, Issue:2

    Topics: Aging; Anilino Naphthalenesulfonates; Animals; Electron Transport Complex IV; Fluorescent Dyes; Lipid Peroxidation; Lysine; Male; Mitochondria, Heart; Myocardium; Oxidation-Reduction; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tryptophan; Tyrosine

2008
Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:5

    Topics: Age Factors; Aging; Aldehydes; Animals; Carbonic Anhydrase III; Hindlimb Suspension; LIM Domain Proteins; Male; Muscle Proteins; Muscle, Skeletal; Oxidation-Reduction; Proteomics; Rats; Rats, Inbred F344; Time Factors; Tyrosine

2008
Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:6

    Topics: Aging; Animals; Blotting, Western; Catalase; Female; Hindlimb Suspension; Hydrogen Peroxide; Male; Malondialdehyde; Muscle, Skeletal; Organ Size; Oxidative Stress; Rats; Rats, Inbred BN; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Tyrosine

2008
Effect of nitric oxide on auditory cortical neurons of aged rats.
    Neuroscience letters, 2008, Dec-05, Volume: 447, Issue:1

    Topics: Age Factors; Aging; Animals; Auditory Cortex; In Vitro Techniques; Male; Membrane Potentials; NADP; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Rats; Rats, Sprague-Dawley; Tyrosine

2008
Inflammatory and redox status of ponies with a history of pasture-associated laminitis.
    Veterinary immunology and immunopathology, 2009, Jun-15, Volume: 129, Issue:3-4

    Topics: Aging; Animal Husbandry; Animals; Cytokines; Female; Foot Diseases; Hoof and Claw; Horse Diseases; Horses; Inflammation; Oxidation-Reduction; Risk Factors; Superoxide Dismutase; Tyrosine

2009
B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2009, Volume: 64, Issue:1

    Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Carotid Arteries; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Femoral Artery; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Superoxides; Tyrosine; Vascular Resistance; Vasodilation; Vasodilator Agents

2009
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production.
    Free radical research, 2009, Volume: 43, Issue:5

    Topics: Aging; Amino Acid Sequence; Animals; Brain; Coenzyme A-Transferases; Cytochromes c; Energy Metabolism; Male; Mitochondria; Mitochondrial Proteins; Mitochondrial Proton-Translocating ATPases; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Reactive Nitrogen Species; Tandem Mass Spectrometry; Tyrosine

2009
Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 297, Issue:1

    Topics: Aging; Air; Animals; Animals, Newborn; Body Weight; Bronchoalveolar Lavage Fluid; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Epithelial Cells; Gene Deletion; Hyperoxia; Mice; NADPH Oxidases; Oxygen; Pneumonia; Protein Transport; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein C; Survival Analysis; Tyrosine

2009
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.
    The Journal of physiology, 2009, Jul-01, Volume: 587, Issue:Pt 13

    Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascular; In Vitro Techniques; Male; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Exertion; Superoxide Dismutase; Tyrosine; Vasodilation

2009
Age-related changes in the insulin receptor β in the gerbil hippocampus.
    Neurochemical research, 2009, Volume: 34, Issue:12

    Topics: Aging; Animals; Dentate Gyrus; Gerbillinae; Hippocampus; Immunohistochemistry; Male; Memory Disorders; Mossy Fibers, Hippocampal; Phosphorylation; Receptor, Insulin; Tyrosine

2009
Aging impairs flow-induced dilation in coronary arterioles: role of NO and H(2)O(2).
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:3

    Topics: Aging; Animals; Antioxidants; Arterioles; Catalase; Coronary Circulation; Cyclic N-Oxides; Deferoxamine; Hydrogen Peroxide; Male; Microscopy, Fluorescence; Nitric Oxide; Rats; Rats, Inbred F344; Reactive Oxygen Species; RNA, Messenger; Siderophores; Spin Labels; Superoxide Dismutase; Tyrosine; Vasodilation

2009
Run for your life: exercise, oxidative stress and the ageing endothelium.
    The Journal of physiology, 2009, Sep-01, Volume: 587, Issue:Pt 17

    Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascular; Male; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Exertion; Superoxide Dismutase; Tyrosine; Vasodilation

2009
eNOS uncoupling and endothelial dysfunction in aged vessels.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Acetylcholine; Age Factors; Aging; Alcohol Oxidoreductases; Animals; Biopterins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Enzyme Stability; GTP Cyclohydrolase; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Multimerization; Pterins; Superoxides; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents

2009
Regulation of membrane band 3 Tyr-phosphorylation by proteolysis of p72(Syk) and possible involvement in senescence process.
    Acta biochimica et biophysica Sinica, 2009, Volume: 41, Issue:10

    Topics: Aging; Anion Exchange Protein 1, Erythrocyte; Erythrocyte Membrane; Erythrocytes; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Peptide Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Syk Kinase; Tyrosine

2009
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:11

    Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Humans; Neurons; Parkinson Disease; Phosphorylation; Serine; Tyrosine

2009
Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.
    Acta oto-laryngologica, 2009, Volume: 129, Issue:12

    Topics: Aging; Aldehydes; Animals; Calcium Channels; Ear, Inner; Glucuronidase; Klotho Proteins; Mice; Mice, Inbred CBA; Microscopy; Superoxide Dismutase; TRPV Cation Channels; Tyrosine

2009
Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance.
    Molecular and cellular biology, 2010, Volume: 30, Issue:7

    Topics: Aging; Animals; Diet; Dietary Fats; Eating; Energy Metabolism; Female; Gene Knock-In Techniques; Humans; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuropeptides; Obesity; Receptors, Leptin; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Tyrosine

2010
Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane.
    Experimental eye research, 2010, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Bruch Membrane; Chromatography, High Pressure Liquid; Humans; Lipofuscin; Mass Spectrometry; Middle Aged; Nitrosation; Pyridinium Compounds; Retinoids; Tyrosine

2010
Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 298, Issue:5

    Topics: Adenosine Triphosphate; Age Factors; Aging; Analysis of Variance; Animals; Binding Sites; Blotting, Western; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Immunoprecipitation; Liver; Male; Mitochondria; Mitochondrial Proton-Translocating ATPases; Nitrates; Oxidative Stress; Rats; Rats, Wistar; Tyrosine

2010
Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction.
    The Journal of physiology, 2010, Apr-15, Volume: 588, Issue:Pt 8

    Topics: Adrenergic Uptake Inhibitors; Aged; Aging; Biopterins; Dose-Response Relationship, Drug; Female; Humans; Male; Norepinephrine; Oxidative Stress; Regional Blood Flow; Skin; Tyramine; Tyrosine; Vasoconstriction; Young Adult

2010
Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle.
    Aging, 2009, May-22, Volume: 1, Issue:6

    Topics: Aging; Animals; Creatine Kinase; Glycogen Phosphorylase; Kinetics; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Oxidative Stress; Protein Carbonylation; Tyrosine

2009
Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 298, Issue:5

    Topics: Adaptation, Physiological; Age Factors; Aging; Animals; Blotting, Western; Calcium; Exercise Test; HSP70 Heat-Shock Proteins; Male; Muscle, Skeletal; Oxidative Stress; Physical Conditioning, Animal; Physical Endurance; Protein Carbonylation; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine

2010
Age-related changes in nitric oxide synthase in the lateral geniculate nucleus of rats.
    Journal of molecular histology, 2010, Volume: 41, Issue:2-3

    Topics: Aging; Animals; Geniculate Bodies; Immunohistochemistry; Male; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase Type I; Rats; Rats, Inbred F344; Tyrosine

2010
Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance.
    Experimental gerontology, 2010, Volume: 45, Issue:9

    Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Weight; Cytokines; Gene Deletion; Glucose Clamp Technique; Hyperinsulinism; Inflammation; Insulin Resistance; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nitric Oxide Synthase Type II; Oxygen Consumption; Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Tyrosine

2010
Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults.
    Human brain mapping, 2011, Volume: 32, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Brain Mapping; Corpus Striatum; Dopamine; Fluorine Radioisotopes; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Memory, Short-Term; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Tyrosine; Young Adult

2011
Pulmonary exposure to carbon black nanoparticles and vascular effects.
    Particle and fibre toxicology, 2010, Nov-05, Volume: 7

    Topics: Administration, Inhalation; Aging; Animals; Apolipoproteins E; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Heme Oxygenase-1; In Vitro Techniques; Intercellular Adhesion Molecule-1; Lung; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Nanoparticles; Oxidative Stress; Plaque, Atherosclerotic; Pneumonia; Soot; Time Factors; Tyrosine; Vascular Cell Adhesion Molecule-1

2010
The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation.
    Free radical biology & medicine, 2011, Jan-15, Volume: 50, Issue:2

    Topics: Aging; Animals; Blotting, Western; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Endotoxemia; Extracellular Space; Inflammation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Tyrosine

2011
Proteins containing oxidized amino acids induce apoptosis in human monocytes.
    The Biochemical journal, 2011, Apr-01, Volume: 435, Issue:1

    Topics: Aging; Annexin A5; Apoptosis; Caspase 3; Cell Line; Ceroid; DNA Fragmentation; Enzyme Activation; Humans; Intracellular Membranes; Levodopa; Lipofuscin; Lysosomes; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Monocytes; Oxidation-Reduction; Permeability; Protein Biosynthesis; Tyrosine

2011
Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2011, Volume: 66, Issue:4

    Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Cytokines; Endothelium, Vascular; Forkhead Box Protein O3; Forkhead Transcription Factors; I-kappa B Kinase; Male; Mice; NADPH Oxidases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; Salicylates; Superoxide Dismutase; Tyrosine; Vasodilation

2011
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.
    Aging cell, 2011, Volume: 10, Issue:5

    Topics: Aging; Animals; Blotting, Western; Carbonic Anhydrase III; Electric Stimulation; Ethidium; Fluoresceins; Fluorescence; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxiredoxins; Peroxynitrous Acid; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Tyrosine

2011
The lumbrical muscle: a novel in situ system to evaluate adult skeletal muscle proteolysis and anticatabolic drugs for therapeutic purposes.
    Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:6

    Topics: Adrenergic beta-2 Receptor Agonists; Aging; Animals; Cyclic AMP; Drug Evaluation, Preclinical; In Vitro Techniques; Male; Muscle Denervation; Muscle Proteins; Muscle, Skeletal; Proteolysis; Rats; Rats, Wistar; Signal Transduction; Tyrosine

2011
Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress.
    Aging cell, 2011, Volume: 10, Issue:6

    Topics: Adult; Aging; Brachial Artery; Cardiovascular Diseases; Endothelial Cells; Endothelium, Vascular; Exercise; Gene Expression; Humans; Male; Middle Aged; NADPH Oxidases; Oxidative Stress; Oxygen Consumption; Risk Factors; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Vasodilation

2011
Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat.
    The Journal of physiology, 2011, Dec-15, Volume: 589, Issue:Pt 24

    Topics: Aging; Animals; Aorta; Chronic Disease; Hydrogen Peroxide; Kidney; Kidney Diseases; Male; NADPH Oxidases; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Superoxide Dismutase; Tyrosine

2011
Ishemia-reperfusion enhances GAPDH nitration in aging skeletal muscle.
    Aging, 2011, Volume: 3, Issue:10

    Topics: Aging; Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Mass Spectrometry; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nitrates; Reperfusion Injury; RNA, Messenger; Tyrosine

2011
Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats.
    Neurobiology of aging, 2012, Volume: 33, Issue:9

    Topics: Age Factors; Aging; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Immunoprecipitation; Male; Maze Learning; Nerve Growth Factor; Nerve Growth Factors; Plasminogen; Protein Precursors; Rats; Rats, Inbred F344; Reaction Time; Tissue Plasminogen Activator; Tyrosine

2012
Cumulative 3-nitrotyrosine in specific muscle proteins is associated with muscle loss during aging.
    Experimental gerontology, 2012, Volume: 47, Issue:2

    Topics: Aging; Animals; Biomarkers; Body Weight; Energy Intake; Hindlimb; Mitochondria, Muscle; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Myofibrils; Organ Size; Protein Carbonylation; Quadriceps Muscle; Rats; Rats, Wistar; Sarcopenia; Tyrosine

2012
A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging.
    Mechanisms of ageing and development, 2012, Volume: 133, Issue:8

    Topics: Aging; Animals; Brain; Cognition; Dietary Supplements; Growth Hormone; Mice; Mice, Transgenic; Mitochondria; Stress, Physiological; Tyrosine

2012
Evidence of increased oxidative stress in aged mesenteric lymphatic vessels.
    Lymphatic research and biology, 2012, Volume: 10, Issue:2

    Topics: Age Factors; Aging; Animals; Blotting, Western; Immunohistochemistry; Lipid Peroxidation; Lymphatic Vessels; Male; Mesentery; Mitochondria; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Thiobarbituric Acid Reactive Substances; Tyrosine

2012
Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.
    Experimental gerontology, 2012, Volume: 47, Issue:8

    Topics: Aging; Animals; Antioxidants; Aorta; Collagen Type I; Drug Evaluation, Preclinical; Elasticity; Elastin; Glycation End Products, Advanced; Male; Mice; Oxidative Stress; Pyrogallol; Sodium Nitrite; Superoxides; Tissue Culture Techniques; Transforming Growth Factor beta; Tyrosine; Vascular Stiffness

2012
Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization.
    Atherosclerosis, 2012, Volume: 223, Issue:1

    Topics: Age Factors; Aging; Animals; Blood Flow Velocity; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Hindlimb; Ischemia; Laser-Doppler Flowmetry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; NADPH Oxidase 2; NADPH Oxidases; Neovascularization, Physiologic; Oxidative Stress; Recovery of Function; Regional Blood Flow; Stem Cells; Superoxides; Time Factors; Tyrosine; Vascular Diseases

2012
Altered neuronal nitric oxide synthase in the aging vascular system: implications for estrogens therapy.
    Endocrinology, 2012, Volume: 153, Issue:8

    Topics: Aging; Animals; Aorta, Thoracic; Arginine; Blotting, Western; Estradiol; Female; In Vitro Techniques; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Ovariectomy; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine

2012
Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.
    Aging cell, 2012, Volume: 11, Issue:6

    Topics: Aging; Amino Acid Motifs; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain; Cognition; Gene Expression Regulation; Gene Knock-In Techniques; Glycine; Mice; Mice, Transgenic; Motor Activity; Motor Endplate; Protein Structure, Tertiary; Receptor, trkA; Signal Transduction; Synapses; Tyrosine

2012
Curcumin ameliorates arterial dysfunction and oxidative stress with aging.
    Experimental gerontology, 2013, Volume: 48, Issue:2

    Topics: Age Factors; Aging; Animals; Antioxidants; Aorta; Carotid Arteries; Collagen Type I; Curcumin; Dose-Response Relationship, Drug; Elastin; Endothelium, Vascular; Glycation End Products, Advanced; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pulse Wave Analysis; Superoxide Dismutase; Superoxides; Tyrosine; Vascular Stiffness; Vasodilation; Vasodilator Agents

2013
Differential hepatic protein tyrosine nitration of mouse due to aging - effect on mitochondrial energy metabolism, quality control machinery of the endoplasmic reticulum and metabolism of drugs.
    Biochemical and biophysical research communications, 2013, Jan-04, Volume: 430, Issue:1

    Topics: Aging; Animals; Endoplasmic Reticulum; Energy Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Pharmaceutical Preparations; Proteins; Reactive Nitrogen Species; Tyrosine; Xenobiotics

2013
Chronic Tempol treatment restores pharmacological preconditioning in the senescent rat heart.
    American journal of physiology. Heart and circulatory physiology, 2013, Mar-01, Volume: 304, Issue:5

    Topics: Aging; Animals; Antioxidants; Calcium; Cardiotonic Agents; Cyclic N-Oxides; Heart; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Inbred F344; Spin Labels; Superoxide Dismutase; Tyrosine

2013
Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade.
    Kidney international, 2002, Volume: 62, Issue:3

    Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Hypertension, Renal; Immunoenzyme Techniques; Kidney Failure, Chronic; Kidney Glomerulus; Losartan; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Tyrosine

2002
Immunohistochemical study on the distribution of nitrotyrosine and neuronal nitric oxide synthase in aged rat cerebellum.
    Brain research, 2002, Oct-04, Volume: 951, Issue:2

    Topics: Aging; Animals; Cerebellar Cortex; Cerebellum; Image Processing, Computer-Assisted; Immunohistochemistry; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Purkinje Cells; Rats; Rats, Sprague-Dawley; Tyrosine; Up-Regulation

2002
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:9

    Topics: Aging; Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Drug Resistance; Humans; Insulin-Like Growth Factor I; Interleukin-1; Macaca fascicularis; Osteoarthritis; Oxidation-Reduction; Tyrosine

2002
Proteasome function and protein oxidation in the aged retina.
    Experimental eye research, 2002, Volume: 75, Issue:3

    Topics: Aging; Aldehydes; Animals; Blotting, Western; Caseins; Chymotrypsin; Cysteine Endopeptidases; Eye Proteins; Male; Multienzyme Complexes; Oxidation-Reduction; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred BN; Rats, Inbred F344; Retina; Tyrosine

2002
Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.
    Brain research, 2002, Dec-13, Volume: 957, Issue:2

    Topics: Acetylcarnitine; Aging; Animals; Body Weight; Cerebral Cortex; Down-Regulation; Encephalitis; Exploratory Behavior; Male; Melatonin; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; RNA, Messenger; Tyrosine

2002
Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:4

    Topics: Adenoviridae; Aging; Animals; beta-Galactosidase; Cell Line; Cyclic GMP; Genetic Vectors; Humans; Male; Microscopy, Confocal; Penile Erection; Penis; Rats; Rats, Inbred BN; Recombinant Fusion Proteins; RNA, Messenger; Superoxide Dismutase; Superoxides; Transfection; Tyrosine

2003
Relation of aging with oxidative protein damage parameters in the rat skeletal muscle.
    Clinical biochemistry, 2003, Volume: 36, Issue:1

    Topics: Aging; Animals; Carbon; Lipid Peroxidation; Lipid Peroxides; Male; Muscle, Skeletal; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Sulfhydryl Compounds; Time Factors; Tyrosine

2003
Changes in ultrastructural characteristics of endolymphatic sac ribosome-rich cells of the rat during development.
    Hearing research, 2003, Volume: 176, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Embryonic and Fetal Development; Endolymphatic Sac; Fucose; Microscopy, Electron; Organelles; Rats; Rats, Wistar; Ribosomes; Tyrosine

2003
Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats.
    Life sciences, 2003, Aug-01, Volume: 73, Issue:11

    Topics: Adipose Tissue; Aging; Animals; Animals, Newborn; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Sodium Glutamate; Tyrosine

2003
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates; Glycine; Guinea Pigs; Histidine; Leucine; Lysine; Nerve Tissue Proteins; Nervous System; Phenylalanine; Research; Serine; Spinal Cord; Threonine; Tyrosine; Valine

1964
THE DEVELOPMENT OF PIGMENTATION AND ENZYME ACTIVITY IN THE NUCLEUS SUBSTANTIAE NIGRAE OF THE CAT.
    Journal of anatomy, 1965, Volume: 99

    Topics: Aging; Amino Acid Oxidoreductases; Animals; Animals, Newborn; Autoradiography; Brain; Carbon Isotopes; Catecholamines; Cats; Pigmentation; Research; Substantia Nigra; Tyrosine

1965
STRUCTURE OF COLLAGEN FROM HUMAN TENDON AS INFLUENCED BY AGE AND SEX.
    Journal of gerontology, 1965, Volume: 20

    Topics: Adolescent; Aging; Child; Collagen; Fluorescence; Histocytochemistry; Humans; Infant; Nitrogen; Protein Hydrolysates; Sex; Spectrophotometry; Tendons; Tyrosine

1965
THE ENZYMATIC BASIS OF TYROSYLURIA IN RATS FED TYROSINE.
    The Journal of biological chemistry, 1964, Volume: 239

    Topics: Aging; Amino Acids; Diet; Hydrolases; Liver; Phenylketonurias; Rats; Research; Tyrosine; Tyrosine Transaminase

1964
THE CLEAVAGE OF TYROSYL PEPTIDES BY PEPSIN FROM COLLAGEN SOLUBILISED BY THE NISHIHARA TECHNIQUE.
    Biochimica et biophysica acta, 1965, Mar-08, Volume: 97

    Topics: Aging; Biochemical Phenomena; Biochemistry; Chromatography; Collagen; Electrophoresis; Gelatin; Pepsin A; Peptides; Protein Denaturation; Tendons; Tyrosine

1965
Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosis.
    Experimental gerontology, 2003, Volume: 38, Issue:10

    Topics: Aging; Animals; Apoptosis; B-Lymphocytes; Cell Division; Immunophenotyping; Interleukin-7; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Knockout; Phosphorylation; Tyrosine

2003
Altered regulation of Fc gamma RII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Dec-01, Volume: 171, Issue:11

    Topics: Aging; Amino Acid Motifs; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; B-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Cellular Senescence; Dendritic Cells, Follicular; Down-Regulation; Germinal Center; Kinetics; Lymph Nodes; Lymphocyte Activation; Lymphocyte Count; Mice; Mice, Inbred BALB C; Mice, Knockout; Peanut Agglutinin; Pertussis Vaccine; Receptors, Complement 3b; Receptors, Complement 3d; Receptors, IgG; Signal Transduction; Tyrosine

2003
Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:1

    Topics: Aging; Animals; Body Weight; Cardiotonic Agents; Estrogens; Ethylenediamines; Female; Heart; Heart Ventricles; Myocardial Ischemia; Myocardial Reperfusion Injury; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Size; Organometallic Compounds; Ovariectomy; Rats; Rats, Sprague-Dawley; Recovery of Function; Superoxide Dismutase; Tyrosine; Uterus

2004
Tyrosine phosphorylation-dependent activation of NFkappaB is compromised in T cells from the elderly.
    Experimental gerontology, 2004, Volume: 39, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Enzyme Inhibitors; Humans; Hydrogen Peroxide; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Tyrosine Phosphatases; T-Lymphocytes; Tyrosine; Vanadates

2004
Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat.
    Annals of the New York Academy of Sciences, 2004, Volume: 1019

    Topics: Aging; Animals; Caloric Restriction; Insulin; Lipid Metabolism; Liver; Male; Muscle, Skeletal; Mutation; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor, Insulin; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Tyrosine; Up-Regulation

2004
Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Biomarkers; Brain; Cells, Cultured; Disease Models, Animal; Down-Regulation; Glutamate-Ammonia Ligase; Lipid Peroxidation; Memory Disorders; Mice; Mice, Inbred Strains; Neurons; Oligonucleotides, Antisense; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Tyrosine

2004
Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:1

    Topics: Aging; Animals; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Myocardium; Nanotechnology; Proteins; Proteomics; Rats; Rats, Inbred BN; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tyrosine

2005
Beta2-agonist administration increases sarcoplasmic reticulum Ca2+-ATPase activity in aged rat skeletal muscle.
    American journal of physiology. Endocrinology and metabolism, 2005, Volume: 288, Issue:3

    Topics: Adrenergic beta-Agonists; Aging; Animals; Blotting, Western; Calcium; Calcium-Transporting ATPases; Cell Fractionation; Fenoterol; Kinetics; Male; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Relaxation; Muscle, Skeletal; Myosin Heavy Chains; Protein Isoforms; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrometry, Fluorescence; Tyrosine

2005
Deletion of p66shc gene protects against age-related endothelial dysfunction.
    Circulation, 2004, Nov-02, Volume: 110, Issue:18

    Topics: Adaptor Proteins, Signal Transducing; Aging; Animals; Aorta; Endothelium, Vascular; Isometric Contraction; Longevity; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Proteins; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Superoxide Dismutase; Tyrosine; Vasoconstriction

2004
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.
    Cell death and differentiation, 2005, Volume: 12, Issue:2

    Topics: Aging; Animals; Apoptosis; Apoptosis Inducing Factor; Autophagy; Brain Injuries; Calpain; Caspase 3; Caspases; Cell Death; Cytochromes c; Disease Models, Animal; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondria; Necrosis; Neurons; Protein Transport; Tyrosine

2005
Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2005, Volume: 15, Issue:1

    Topics: Adipose Tissue; Aging; Animals; Area Under Curve; Enzyme-Linked Immunosorbent Assay; Female; Glucose; Growth Hormone; Humans; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Janus Kinase 2; Lipid Metabolism; Liver; Muscles; Obesity; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Time Factors; Tyrosine

2005
Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction.
    Free radical research, 2005, Volume: 39, Issue:3

    Topics: Aging; Animals; Caloric Restriction; Diet; Energy Intake; Inflammation; Kidney; Lipopolysaccharides; Male; Oxidation-Reduction; Oxidative Stress; Peroxidase; Rats; Rats, Inbred F344; Tyrosine; Vascular Cell Adhesion Molecule-1

2005
Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry.
    The Journal of biological chemistry, 2005, Jun-24, Volume: 280, Issue:25

    Topics: Aging; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Molecular Sequence Data; Muscle Proteins; Muscle, Skeletal; Nanotechnology; Nitrates; Proteome; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tyrosine

2005
Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential.
    Journal of immunology (Baltimore, Md. : 1950), 2005, May-15, Volume: 174, Issue:10

    Topics: Aging; Animals; Autoantigens; CD8 Antigens; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Proliferation; Clonal Deletion; Cyclin-Dependent Kinase Inhibitor p21; Female; H-Y Antigen; Immunophenotyping; Intestinal Mucosa; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Weight; Phosphorylation; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocyte Subsets; Thymus Gland; Tyrosine

2005
Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.
    Neuroreport, 2005, May-31, Volume: 16, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Female; Genotype; Histidine; Humans; Male; Memory; Middle Aged; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2A; Statistics as Topic; Time Factors; Tyrosine

2005
Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.
    Brain research. Molecular brain research, 2005, Aug-18, Volume: 138, Issue:2

    Topics: Aging; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Female; Humans; Inclusion Bodies; Male; Mice; Mice, Transgenic; Mutation, Missense; Nerve Degeneration; Neurons; Phosphorylation; Protein Isoforms; tau Proteins; Tauopathies; Tyrosine; Up-Regulation

2005
Hepatocellular carcinoma and the penetrance of HFE C282Y mutations: a cross sectional study.
    BMC gastroenterology, 2005, Jun-01, Volume: 5

    Topics: Aging; Carcinoma, Hepatocellular; Case-Control Studies; Cross-Sectional Studies; Cysteine; Female; Genetic Predisposition to Disease; Genotype; Hemochromatosis Protein; Histocompatibility Antigens Class I; Homozygote; Humans; Liver Neoplasms; Male; Membrane Proteins; Middle Aged; Mutation; Penetrance; Tyrosine

2005
Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging.
    Journal of neurochemistry, 2005, Volume: 93, Issue:5

    Topics: Aging; Animals; Blotting, Western; Brain; Caveolin 1; Caveolins; Chromatography, High Pressure Liquid; Immunoprecipitation; Mass Spectrometry; Membrane Proteins; Rats; Rats, Inbred BN; Rats, Inbred F344; Tubulin; Tyrosine

2005
Neonatal cerebral hypoxia-ischemia: involvement of FAK-dependent pathway.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2005, Volume: 23, Issue:7

    Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Crk-Associated Substrate Protein; Focal Adhesion Kinase 1; Hypoxia, Brain; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; src-Family Kinases; Tyrosine

2005
Tau is hyperphosphorylated in the insulin-like growth factor-I null brain.
    Endocrinology, 2005, Volume: 146, Issue:12

    Topics: Aging; Animals; Brain; Drug Residues; Insulin-Like Growth Factor I; Lipofuscin; Male; Mice; Mice, Knockout; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; tau Proteins; Tyrosine

2005
3-Nitrotyrosine modification of SERCA2a in the aging heart: a distinct signature of the cellular redox environment.
    Biochemistry, 2005, Oct-04, Volume: 44, Issue:39

    Topics: Adenosine Triphosphate; Age Factors; Aging; Animals; Calcium-Transporting ATPases; Cell Respiration; Heart; Male; Muscle, Skeletal; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stress, Physiological; Tyrosine

2005
Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1

    Topics: Acetone; Administration, Oral; Aging; Animals; Blotting, Western; Body Weight; Dichloroacetic Acid; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Glutathione Transferase; Humans; Liver; Male; Maleates; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine

2006
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:6

    Topics: Aging; Animals; Calcium-Transporting ATPases; Cardiovascular Diseases; Dithionite; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Kidney; Oxidative Stress; Peroxynitrous Acid; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Tyrosine

2006
Expression and activity patterns of nitric oxide synthases and antioxidant enzymes reveal a substantial heterogeneity between cardiac and vascular aging in the rat.
    Biogerontology, 2005, Volume: 6, Issue:5

    Topics: Aging; Animals; Femoral Artery; Glutathione; Heart; In Vitro Techniques; Isoenzymes; Male; Myocardial Stunning; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perfusion; Rats; Rats, Inbred F344; Renal Artery; Superoxide Dismutase; Tyrosine

2005
Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:5

    Topics: Adult; Age Factors; Aged; Aging; Apoptosis; Chemotaxis, Leukocyte; Down-Regulation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunity, Cellular; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Neutrophils; Phosphorylation; Protein Phosphatase 1; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Reactive Oxygen Species; Serine; src-Family Kinases; Tyrosine

2006
Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:7

    Topics: Aconitate Hydratase; Aging; Animals; Apoptosis; Calcium; Cytochromes c; Diastole; Gene Expression Regulation; Heart Ventricles; Metallothionein; Mice; Mice, Transgenic; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; Pyrogallol; rhoA GTP-Binding Protein; Superoxides; Tyrosine

2006
Age-associated tyrosine nitration of rat skeletal muscle glycogen phosphorylase b: characterization by HPLC-nanoelectrospray-tandem mass spectrometry.
    Experimental gerontology, 2006, Volume: 41, Issue:4

    Topics: Aging; Animals; Base Sequence; Chromatography, High Pressure Liquid; Glycogen Phosphorylase, Muscle Form; Longevity; Molecular Sequence Data; Muscle, Skeletal; Peroxynitrous Acid; Rats; Rats, Inbred BN; Rats, Inbred F344; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine

2006
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
    The American journal of pathology, 2006, Volume: 168, Issue:5

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Cortex; Disease Models, Animal; Homozygote; Mice; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Oxidative Stress; Respiration; Superoxide Dismutase; Tyrosine

2006
Function of the rat carotid body chemoreceptors in ageing.
    Journal of neurochemistry, 2006, Volume: 99, Issue:3

    Topics: Acidosis; Aging; Animals; Carotid Body; Catecholamines; Catechols; Chemoreceptor Cells; Female; Hypercapnia; Hypoxia; Male; Potassium; Rats; Rats, Sprague-Dawley; Seasons; Tyrosine; Tyrosine 3-Monooxygenase

2006
Protein nitration with aging in the rat semimembranosus and soleus muscles.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:8

    Topics: Aging; Animals; Male; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Inbred F344; Tyrosine

2006
Oxidative imbalance in the aging inner ear.
    Neurobiology of aging, 2007, Volume: 28, Issue:10

    Topics: Aging; Aldehydes; Animals; Apoptosis Inducing Factor; Biomarkers; Cochlea; Free Radicals; Hair Cells, Auditory; Male; Mice; Mice, Inbred CBA; Nerve Degeneration; Neurons, Afferent; Organ of Corti; Oxidative Stress; Spiral Ganglion; Superoxide Dismutase; Tyrosine

2007
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
    Endocrinology, 2007, Volume: 148, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cell Line, Transformed; Down-Regulation; Gene Expression; Gene Expression Profiling; Gene Transfer Techniques; Gluconeogenesis; Hepatocytes; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrosine; Up-Regulation

2007
The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction.
    Mechanisms of ageing and development, 2007, Volume: 128, Issue:2

    Topics: Acetylcholine; Aging; Animals; Aorta; Diastole; Endothelium, Vascular; Heart Diseases; In Vitro Techniques; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Tyrosine; Vasodilation; Ventricular Function, Left

2007
Astrocytes aged in vitro show a decreased neuroprotective capacity.
    Journal of neurochemistry, 2007, Volume: 101, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Heme Oxygenase-1; Hydrogen Peroxide; Nerve Growth Factors; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Reactive Oxygen Species; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine

2007
Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging.
    Journal of neurochemistry, 2007, Volume: 100, Issue:6

    Topics: Aging; Amino Acid Sequence; Animals; Blotting, Western; Cerebellum; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Proteins; Proteomics; Rats; Rats, Inbred F344; Tyrosine

2007
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
    The Journal of biological chemistry, 2007, Jun-29, Volume: 282, Issue:26

    Topics: Aging; Anticoagulants; Apoptosis; Binding Sites; Complement Factor H; Glycosaminoglycans; Heparin; Histidine; Humans; Macular Degeneration; Polymorphism, Single Nucleotide; Protein Structure, Quaternary; Protein Structure, Tertiary; Surface Plasmon Resonance; Tyrosine

2007
Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction.
    Experimental gerontology, 2007, Volume: 42, Issue:7

    Topics: Acetylcholine; Aging; Animals; Enzyme Inhibitors; Heart; Immunohistochemistry; Indoles; Models, Animal; Myocardium; Phenylephrine; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Tyrosine

2007
Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration.
    Molecular immunology, 2007, Volume: 44, Issue:13

    Topics: Aged, 80 and over; Aging; Amino Acid Substitution; Animals; Cell Line; Cells, Cultured; Complement C3b Inactivator Proteins; Complement Factor H; Female; Histidine; Humans; Macular Degeneration; Protein Isoforms; Spodoptera; Tyrosine

2007
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.
    Circulation research, 2007, Jun-08, Volume: 100, Issue:11

    Topics: Adolescent; Adult; Aged; Aging; Brachial Artery; Catalase; Endothelial Cells; Fluorescent Antibody Technique; Humans; Male; Middle Aged; NADPH Oxidases; Oxidative Stress; Reference Values; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Up-Regulation; Vasodilation; Veins; Xanthine Oxidase

2007
Developmental changes in the association of NMDA receptors with lipid rafts.
    Journal of neuroscience research, 2007, Volume: 85, Issue:9

    Topics: Aging; Animals; Cholesterol; Disks Large Homolog 4 Protein; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Membrane Proteins; Nerve Tissue Proteins; Neuropeptides; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Tyrosine

2007
Age modulates the nitric oxide system response in the ischemic cerebellum.
    Brain research, 2007, Jul-09, Volume: 1157

    Topics: Aging; Animals; Astrocytes; Brain Ischemia; Cerebellar Diseases; Cerebellum; Down-Regulation; Glial Fibrillary Acidic Protein; Gliosis; Isoenzymes; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Reperfusion Injury; Time Factors; Tyrosine; Up-Regulation

2007
Abnormal processing of tau in the brain of aged TgCRND8 mice.
    Neurobiology of disease, 2007, Volume: 27, Issue:3

    Topics: Aging; Animals; Brain; Female; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Inclusion Bodies; Male; MAP Kinase Kinase 4; Mice; Mice, Transgenic; Phosphorylation; Plaque, Amyloid; tau Proteins; Tyrosine

2007
Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat.
    Redox report : communications in free radical research, 2007, Volume: 12, Issue:4

    Topics: Aging; Aldehydes; Analysis of Variance; Animals; Blood Pressure; Female; Heart; Heat-Shock Proteins; Immunoblotting; Immunohistochemistry; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred BN; Rats, Inbred F344; Reactive Oxygen Species; Regression Analysis; Signal Transduction; Superoxides; Tyrosine

2007
Gender difference as regards myocardial protein oxidation in aged rats: male rats have increased oxidative protein damage.
    Biogerontology, 2007, Volume: 8, Issue:6

    Topics: Aging; Animals; Female; Glutathione; Iron; Lipid Peroxidation; Longevity; Male; Malondialdehyde; Myocardium; Oxidation-Reduction; Oxidative Stress; Peroxides; Protein Carbonylation; Proteins; Rats; Rats, Sprague-Dawley; Sex Factors; Sulfhydryl Compounds; Tyrosine

2007
Plantaris muscle of aged rats demonstrates iron accumulation and altered expression of iron regulation proteins.
    Experimental physiology, 2008, Volume: 93, Issue:3

    Topics: Age Factors; Aging; Animals; Apoferritins; Carrier Proteins; Cation Transport Proteins; Iron; Iron Regulatory Protein 1; Lipid Peroxides; Male; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Inbred F344; Receptors, Transferrin; Tyrosine; Up-Regulation

2008
Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
    Neurobiology of aging, 2009, Volume: 30, Issue:8

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antipsychotic Agents; Anxiety; Brain; Dibenzothiazepines; Disease Models, Animal; Female; Male; Memory Disorders; Mice; Mice, Transgenic; Plaque, Amyloid; Presenilin-1; Protease Nexins; Proto-Oncogene Proteins c-bcl-2; Quetiapine Fumarate; Receptors, Cell Surface; Tyrosine

2009
The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.
    The Journal of biological chemistry, 2008, Apr-04, Volume: 283, Issue:14

    Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Fertility; Hydrolases; Intestines; Mutation; Oxidative Stress; Phenotype; Protein Folding; RNA Interference; Tyrosine; Tyrosinemias

2008
Effects of ubiquitin-proteasome system deregulation on the vascular senescence and atherosclerosis process in elderly patients.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2008, Volume: 63, Issue:2

    Topics: Aged; Aging; Atherosclerosis; Collagen; Cyclin-Dependent Kinase Inhibitor p16; Disease Progression; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Matrix Metalloproteinase 9; Middle Aged; Proteasome Endopeptidase Complex; Tyrosine; Ubiquitin

2008
Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2008, Volume: 56, Issue:6

    Topics: Aging; Aldehydes; Animals; Autophagy; Energy Metabolism; Heating; Hepatocytes; Immunohistochemistry; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Mitochondria; Oxidative Stress; Peroxisomes; Proteins; Rats; Rats, Inbred F344; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine

2008
[Protein synthesis and the regulation process in the cell].
    Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 50, Issue:5

    Topics: Aging; Animals; Arginine; Autoradiography; Axons; Body Weight; Cell Biology; Cytoplasmic Granules; Glycine; Golgi Apparatus; Guinea Pigs; Hippocampus; Homeostasis; Leucine; Methionine; Mice; Microscopy, Electron; Neurons; Pancreas; Photoreceptor Cells; Protein Biosynthesis; Purkinje Cells; Pyramidal Tracts; Rats; Ribosomes; RNA; RNA, Messenger; Spectrophotometry; Thyroid Gland; Time Factors; Tritium; Tyrosine

1966
Variations in the protein components of human intervertebral disk with age.
    Nature, 1967, Jul-01, Volume: 215, Issue:5096

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Collagen; Humans; Hydroxyproline; Intervertebral Disc; Middle Aged; Nitrogen; Proteins; Statistics as Topic; Tyrosine

1967
Influence of chronic inorganic lead exposure on regional dopamine and 5-hydroxytryptamine turnover in rat brain.
    Neurochemical research, 1984, Volume: 9, Issue:12

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Dopamine; Erythrocytes; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Lead; Lead Poisoning; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Pregnancy; Protoporphyrins; Rats; Serotonin; Tyrosine

1984
Managanese-induced biochemical changes in growing versus adult rats.
    Archives of environmental contamination and toxicology, 1980, Volume: 9, Issue:4

    Topics: Aging; Animals; Biogenic Amines; Body Weight; Brain Chemistry; Liver; Male; Manganese; Metals; Neurotransmitter Agents; Rats; Tryptophan; Tyrosine

1980
Regulation of hepatic tyrosine aminotransferase in genetically obese rats.
    Biochimica et biophysica acta, 1983, Apr-20, Volume: 756, Issue:3

    Topics: Adrenalectomy; Aging; Amino Acids; Animals; Corticosterone; Diet; Disease Models, Animal; Enzyme Activation; Insulin; Liver; Obesity; Rats; Tryptophan; Tyrosine; Tyrosine Transaminase

1983
Effect of catecholamine precursors on stress-induced changes in motor activity, exploration, and brain monoamines in young and aged mice.
    Behavioral neuroscience, 1984, Volume: 98, Issue:3

    Topics: Aging; Animals; Body Temperature Regulation; Brain; Corticosterone; Dopamine; Exploratory Behavior; Male; Mice; Motor Activity; Neurotransmitter Agents; Norepinephrine; Serotonin; Stress, Physiological; Tyrosine

1984
The receptor-mediated activation of tyrosine hydroxylation in the superior cervical ganglion of the rat.
    Journal of neurochemistry, 1981, Volume: 36, Issue:5

    Topics: Aging; Animals; Bucladesine; Carbachol; Dopamine; Ganglia, Spinal; Hydroxylation; Kinetics; Pterins; Rats; Reserpine; Tyrosine

1981
In vitro energy costs of Na+, K+ATPase activity and protein synthesis in muscle from calves differing in age and breed.
    The British journal of nutrition, 1982, Volume: 48, Issue:1

    Topics: Aging; Animals; Cattle; Culture Techniques; Male; Muscle Proteins; Muscles; Oxygen Consumption; Phenylalanine; Sodium-Potassium-Exchanging ATPase; Species Specificity; Tyrosine

1982
Raman spectroscopic study of age-related structural changes in the lens proteins of an intact mouse lens.
    Biochemistry, 1983, Dec-20, Volume: 22, Issue:26

    Topics: Aging; Animals; Body Water; Crystallins; Disulfides; Lens, Crystalline; Mice; Mice, Inbred ICR; Protein Conformation; Spectrum Analysis, Raman; Tryptophan; Tyrosine

1983
Effect of gammahydroxybutyric acid on catecholamine synthesis and utilization in the developing rat brain.
    Journal of neural transmission, 1982, Volume: 54, Issue:1-2

    Topics: Aging; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Female; Hydroxybutyrates; Motor Activity; Norepinephrine; Pregnancy; Rats; Rats, Inbred Strains; Sodium Oxybate; Tyrosine

1982
Newborn phenylalanine/tyrosine metabolism. Implications for screening for phenylketonuria.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:5

    Topics: Aging; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mass Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Tyrosine

1983
Age related changes in blood-to-brain amino acid transport and incorporation into brain protein.
    Neurochemical research, 1983, Volume: 8, Issue:2

    Topics: Aging; Amino Acids; Animals; Blood-Brain Barrier; Brain; Kinetics; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Tyrosine; Valine

1983
Age-related alterations in cardiac protein turnover.
    Journal of molecular and cellular cardiology, 1981, Volume: 13, Issue:6

    Topics: Aging; Animals; Heart; In Vitro Techniques; Insulin; Kinetics; Male; Muscle Proteins; Myocardium; Phenylalanine; Rats; Tyrosine

1981
Effects of centrally and systemically administered L-tyrosine and L-leucine on ovarian function in the old rat.
    Gerontology, 1980, Volume: 26, Issue:5

    Topics: Aging; Animals; Catecholamines; Estrus; Female; Leucine; Levodopa; Ovary; Pregnancy; Preoptic Area; Rats; Serotonin; Tyrosine

1980
Secretion of hypothalamic dopamine into pituitary stalk blood of aged female rats.
    Brain research bulletin, 1981, Volume: 7, Issue:1

    Topics: Aging; Animals; Dopamine; Estrus; Female; Hypothalamus; Levodopa; Median Eminence; Pituitary Gland; Pregnancy; Prolactin; Rats; Tyrosine

1981
Total tubulin and its aminoacylated and non-aminoacylated forms during the development of rat brain.
    European journal of biochemistry, 1980, Volume: 109, Issue:2

    Topics: Aging; Animals; Brain; Carboxypeptidases; Carboxypeptidases A; Kinetics; Microtubules; Rats; Tubulin; Tyrosine

1980
Effect of aging on murine macrophages. Diminished response to IFN-gamma for enhanced oxidative metabolism.
    Journal of immunology (Baltimore, Md. : 1950), 1994, Sep-01, Volume: 153, Issue:5

    Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Caseins; Concanavalin A; Female; Hydrogen Peroxide; Interferon gamma Receptor; Interferon-gamma; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Phosphotyrosine; Receptors, Interferon; Recombinant Proteins; Signal Transduction; Spleen; Tyrosine

1994
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4

    Topics: Aging; Animals; Blotting, Northern; Choline O-Acetyltransferase; Gene Expression Regulation; Hippocampus; Immunohistochemistry; In Situ Hybridization; Nerve Growth Factors; Phosphotyrosine; Prosencephalon; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Tyrosine

1995
A decreased tubular uptake of dopa results in defective renal dopamine production in aged rats.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biological Transport; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Dopamine; Kidney; Kidney Cortex; Male; Microvilli; Monoamine Oxidase; Norepinephrine; Rats; Rats, Wistar; Regression Analysis; Tyrosine

1995
Activation of murine T-cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:4

    Topics: Aging; Animals; Calcium; CD3 Complex; CD4 Antigens; Cross-Linking Reagents; Isoenzymes; Lymphocyte Activation; Mice; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotransferases; Signal Transduction; Spleen; T-Lymphocytes; Type C Phospholipases; Tyrosine

1995
Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer.
    Biochemical and biophysical research communications, 1993, Jul-30, Volume: 194, Issue:2

    Topics: Adenocarcinoma; Aging; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; DNA; DNA, Neoplasm; Embryonic and Fetal Development; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Molecular Sequence Data; Open Reading Frames; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Rats; Rats, Wistar; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Stomach; Stomach Neoplasms; Tyrosine

1993
Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine.
    Gastroenterology, 1994, Volume: 107, Issue:1

    Topics: Aging; Animals; Blotting, Western; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Intestine, Small; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Proteins; ras GTPase-Activating Proteins; Rats; Rats, Wistar; Signal Transduction; Type C Phospholipases; Tyrosine; Weaning

1994
Racemization of tyrosine in the insoluble protein fraction of brunescent aging human lenses.
    The Journal of biological chemistry, 1994, Sep-09, Volume: 269, Issue:36

    Topics: Aging; Chromatography, High Pressure Liquid; Crystallins; Humans; Isomerism; Lens, Crystalline; Magnetic Resonance Spectroscopy; Optical Rotation; Protein Conformation; Spectrometry, Fluorescence; Tyrosine

1994
Epidermal growth factor receptor activation in developing rat kidney.
    The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 2

    Topics: Aging; Animals; Enzyme Activation; ErbB Receptors; Female; Gestational Age; Kidney; Male; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Tyrosine

1994
Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets. Effect of age.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Jul-15, Volume: 151, Issue:2

    Topics: Aging; Animals; Antibodies, Monoclonal; CD3 Complex; CD4-Positive T-Lymphocytes; Concanavalin A; Immunologic Memory; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Phosphorylation; Proteins; Rabbits; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocyte Subsets; Tyrosine

1993
Glutamine force-feeding effect on plasma amino-acid concentrations in growing rats fed a cafeteria diet.
    Reproduction, nutrition, development, 1994, Volume: 34, Issue:2

    Topics: Aging; Amino Acids; Animals; Cysteine; Diet; Glutamine; Ornithine; Proline; Rats; Rats, Wistar; Threonine; Tyrosine

1994
Glutathione levels of the human crystalline lens in aging and its antioxidant effect against the oxidation of lens proteins.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Cataract; Child; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallins; Glutathione; Glutathione Reductase; Humans; Lens, Crystalline; Middle Aged; Oxidation-Reduction; Protein Binding; Thiobarbituric Acid Reactive Substances; Tryptophan; Tyrosine

1993
Protein synthesis in growing and adult rats on casein and gluten nutrition.
    Physiological research, 1993, Volume: 42, Issue:1

    Topics: Aging; Animals; Body Weight; Caseins; Glutens; Male; Protein Biosynthesis; Rats; Rats, Wistar; Regression Analysis; Tyrosine

1993
Local variations in protein structure in the human eye lens: a Raman microspectroscopic study.
    Biochimica et biophysica acta, 1993, Aug-07, Volume: 1164, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Crystallins; Eye Proteins; Humans; Lens, Crystalline; Microchemistry; Middle Aged; Phenylalanine; Protein Conformation; Spectrum Analysis, Raman; Tryptophan; Tyrosine

1993
Organ clearance of tyrosyl-arginine and its effect on amino acid metabolism in young sheep.
    Metabolism: clinical and experimental, 1993, Volume: 42, Issue:8

    Topics: Aging; Amino Acids; Analgesics; Animals; Arginine; Citrulline; Endorphins; Female; Hindlimb; Intestinal Mucosa; Intestines; Isoleucine; Kidney; Leucine; Liver; Metabolic Clearance Rate; Organ Specificity; Phenylalanine; Regional Blood Flow; Sheep; Tyrosine; Valine

1993
Delayed detyrosination of alpha-tubulin from parallel fibre axons and its correlation with impaired synaptogenesis in hypothyroid rat cerebellum.
    Brain research, 1993, Jun-18, Volume: 614, Issue:1-2

    Topics: Aging; Animals; Antibodies, Monoclonal; Axons; Carboxypeptidases; Carboxypeptidases A; Cerebellum; Female; Fluorescent Antibody Technique; Hypothyroidism; Immunohistochemistry; Pregnancy; Rats; Rats, Sprague-Dawley; Synapses; Tubulin; Tyrosine

1993
Gastrin-mediated changes in tyrosine kinases in isolated gastric mucosal cells from young and aged rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1993, Volume: 202, Issue:3

    Topics: Aging; Animals; Cells, Cultured; Gastric Mucosa; Gastrins; Male; Membrane Proteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Time Factors; Tyrosine

1993
Oxidized amino acids in lens protein with age. Measurement of o-tyrosine and dityrosine in the aging human lens.
    The Journal of biological chemistry, 1993, Jun-15, Volume: 268, Issue:17

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Crystallins; Humans; Infant; Isomerism; Lens, Crystalline; Middle Aged; Oxidation-Reduction; Spectrometry, Fluorescence; Tyrosine

1993
Neuroamine related compounds in the CSF of hydrocephalic rabbits.
    Neuroreport, 1995, Sep-11, Volume: 6, Issue:13

    Topics: Aging; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Homovanillic Acid; Hydrocephalus; Hydroxyindoleacetic Acid; Rabbits; Tryptophan; Tyrosine

1995
Increased activation of EGF-receptor tyrosine kinase by EGF and TGF-alpha in the colonic mucosa of aged rats.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1996, Volume: 51, Issue:1

    Topics: Aging; Animals; Bombesin; Colon; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; In Vitro Techniques; Intestinal Mucosa; Male; Phosphorylation; Rats; Rats, Inbred F344; Transforming Growth Factor alpha; Tyrosine

1996
Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process?
    FEBS letters, 1996, Feb-05, Volume: 379, Issue:3

    Topics: Aging; Animals; Calcium; Calcium-Transporting ATPases; Male; Muscle, Skeletal; Nitrates; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Tyrosine

1996
Protection of the aged substantia nigra of the rat against oxidative damage by (-)-deprenyl.
    British journal of pharmacology, 1996, Volume: 117, Issue:8

    Topics: Aging; Animals; Dopamine; Male; Monoamine Oxidase Inhibitors; Oxidative Stress; Rats; Rats, Wistar; Selegiline; Substantia Nigra; Tyrosine

1996
Effect of repeated stress on a number of plasma amino acids and related compounds in young and old rats.
    Physiology & behavior, 1996, Volume: 60, Issue:3

    Topics: Age Factors; Aging; Alanine; Amino Acids; Animals; Male; Rats; Rats, Inbred F344; Stress, Physiological; Tyrosine

1996
Divergent selection for high or low growth rate modifies the response of muscle cells to serum or insulin-like growth factor-I in vitro.
    Growth regulation, 1996, Volume: 6, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Biological Transport; Body Weight; Cell Division; Cells, Cultured; Chickens; DNA; Humans; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Male; Muscle, Skeletal; Protein Biosynthesis; Recombinant Proteins; Thymidine; Tyrosine

1996
Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age.
    Cellular immunology, 1997, Jan-10, Volume: 175, Issue:1

    Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Dimerization; In Vitro Techniques; Lymphocyte Activation; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylation; Receptors, Antigen, T-Cell; Signal Transduction; Tyrosine

1997
Modification of protein surface hydrophobicity and methionine oxidation by oxidative systems.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Apr-01, Volume: 94, Issue:7

    Topics: Aging; Animals; Methionine; Oxidation-Reduction; Proteins; Rats; Rats, Inbred F344; Tryptophan; Tyrosine

1997
Amino acids suppress proteolysis independent of insulin throughout the neonatal period.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 1

    Topics: Aging; Amino Acids; Blood Glucose; Humans; Hydroxylation; Infant, Newborn; Infusions, Intravenous; Insulin; Leucine; Osmolar Concentration; Oxidation-Reduction; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Tyrosine

1997
Oral phenylalanine loading in dopa-responsive dystonia: a possible diagnostic test.
    Neurology, 1997, Volume: 48, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biopterins; Child, Preschool; Dihydroxyphenylalanine; Dopamine Agents; Dystonia; Female; Humans; Male; Middle Aged; Neopterin; Osmolar Concentration; Phenylalanine; Time Factors; Tyrosine

1997
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
    Immunity, 1997, Volume: 7, Issue:1

    Topics: Aging; Animals; Antibodies, Anti-Idiotypic; Antigens, CD; Autoantibodies; B-Lymphocytes; B7-2 Antigen; Calcium-Calmodulin-Dependent Protein Kinases; Chickens; Down-Regulation; Lipopolysaccharides; Membrane Glycoproteins; Mice; Phenotype; Phosphorylation; Pseudogenes; Receptors, IgG; Signal Transduction; src-Family Kinases; Surface Properties; Tyrosine

1997
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.
    Circulation research, 1997, Volume: 81, Issue:4

    Topics: Aging; Animals; Blood Vessels; Endothelium, Vascular; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neovascularization, Physiologic; Ovary; Phosphorylation; Rats; Rats, Inbred F344; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Rest; Skin; Tissue Distribution; Tyrosine; Uterus; Wound Healing

1997
Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice.
    Archives of biochemistry and biophysics, 1997, Oct-01, Volume: 346, Issue:1

    Topics: Aging; Animals; Brain; Energy Intake; Free Radicals; Hydroxyl Radical; Liver; Male; Mice; Muscle Proteins; Muscle, Skeletal; Myocardium; Oxidation-Reduction; Tyrosine

1997
Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Aging; Animals; Antioxidants; Biomarkers; Copper; Female; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxyl Radical; Nitrates; Nitrogen; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Serum Albumin, Bovine; Tyrosine

1998
Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats.
    Cellular immunology, 1998, Apr-10, Volume: 185, Issue:1

    Topics: Aging; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Concanavalin A; Enzyme Activation; Enzyme Induction; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Signal Transduction; T-Lymphocytes; Time Factors; Tyrosine; ZAP-70 Protein-Tyrosine Kinase

1998
Progressive decline in the ability of calmodulin isolated from aged brain to activate the plasma membrane Ca-ATPase.
    Biochemistry, 1998, Jun-30, Volume: 37, Issue:26

    Topics: Aging; Amino Acid Sequence; Animals; Brain Chemistry; Calcium; Calcium-Transporting ATPases; Calmodulin; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Erythrocyte Membrane; Mass Spectrometry; Methionine; Molecular Sequence Data; Oxidation-Reduction; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Secondary; Rats; Rats, Inbred F344; Spectrometry, Fluorescence; Swine; Thermodynamics; Tryptophan; Tyrosine

1998
Decreased association of p56lck with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging.
    Cellular immunology, 1998, Jun-15, Volume: 186, Issue:2

    Topics: Adult; Aged; Aging; Catalysis; CD4 Antigens; CSK Tyrosine-Protein Kinase; Humans; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mitogens; Phosphorylation; Phytohemagglutinins; Protein-Tyrosine Kinases; src-Family Kinases; T-Lymphocytes; Tyrosine

1998
Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70.
    Mechanisms of ageing and development, 1998, Aug-01, Volume: 104, Issue:1

    Topics: Adult; Aged; Aging; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Concanavalin A; Down-Regulation; Humans; Mitogens; Phosphorylation; Phytohemagglutinins; Protein-Tyrosine Kinases; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase

1998
Age-induced increase of leucine enkephalin enzyme degradation in human plasma.
    Peptides, 1998, Volume: 19, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopeptidases; Analysis of Variance; Chromatography, Gel; Chromatography, Thin Layer; Enkephalin, Leucine; Female; Glycine; Humans; Hydrolysis; Kinetics; Male; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Tyrosine

1998
Developmental regulation of tyrosine phosphorylation of the NR2D NMDA glutamate receptor subunit in rat central nervous system.
    Journal of neurochemistry, 1998, Volume: 71, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Brain; Enzyme Inhibitors; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Thalamus; Tyrosine; Vanadates

1998
Neuronal and inducible nitric oxide synthase and nitrotyrosine immunoreactivities in the cerebral cortex of the aging rat.
    Microscopy research and technique, 1998, Oct-01, Volume: 43, Issue:1

    Topics: Aging; Albinism; Animals; Blotting, Western; Cerebral Cortex; Immunohistochemistry; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine

1998
Immunohistochemical detection of dityrosine in lipofuscin pigments in the aged human brain.
    FEBS letters, 1998, Nov-20, Volume: 439, Issue:3

    Topics: Aged; Aging; Antibodies; Brain; Brain Chemistry; Humans; Immunohistochemistry; Lipofuscin; Tyrosine

1998
Increased Zap-70 association with CD3zeta in CD4 T cells from old mice.
    Cellular immunology, 1998, Dec-15, Volume: 190, Issue:2

    Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Humans; Jurkat Cells; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylation; Protein-Tyrosine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Tyrosine; ZAP-70 Protein-Tyrosine Kinase

1998
Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo.
    The American journal of physiology, 1999, Volume: 276, Issue:1

    Topics: Adaptation, Physiological; Aging; Amino Acids; Animals; Antioxidants; Biomarkers; Female; Motor Activity; Muscle, Skeletal; Muscular Atrophy; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Physical Conditioning, Animal; Rats; Rats, Long-Evans; Rats, Wistar; Tyrosine

1999
Developmental regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor in Torpedo electrocyte.
    Molecular and cellular neurosciences, 1999, Volume: 13, Issue:1

    Topics: Aging; Animals; Blotting, Western; Electric Organ; Fluorescent Antibody Technique; Muscle Proteins; Phosphorylation; Phosphotyrosine; Receptors, Nicotinic; Subcellular Fractions; Tissue Distribution; Torpedo; Tyrosine

1999
Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases.
    The Journal of biological chemistry, 1999, Apr-16, Volume: 274, Issue:16

    Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Liver; Male; MAP Kinase Kinase Kinases; Mitogens; Phosphorylation; Proto-Oncogene Proteins c-raf; Rats; Rats, Inbred F344; Tyrosine

1999
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle.
    The Biochemical journal, 1999, Jun-15, Volume: 340 ( Pt 3)

    Topics: Aging; Amino Acid Sequence; Animals; Biological Transport; Calcium; Calcium-Transporting ATPases; Cysteine; Endopeptidases; Isoenzymes; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Nitrates; Nitric Oxide; Oxygen; Peptide Fragments; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Sulfhydryl Compounds; Tyrosine

1999
Age-related impairment of p56lck and ZAP-70 activities in human T lymphocytes activated through the TcR/CD3 complex.
    Experimental gerontology, 1999, Volume: 34, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; CD3 Complex; Cell Cycle Proteins; Female; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-vav; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase

1999
Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status.
    BioFactors (Oxford, England), 1999, Volume: 9, Issue:2-4

    Topics: Aging; Animals; Biomarkers; Coenzymes; Heart; Humans; Kidney; Liver; Lung; Myocardium; Pyridoxine; Rats; Spleen; Tyrosine; Ubiquinone

1999
Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells.
    Mechanisms of ageing and development, 1999, Nov-02, Volume: 111, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; CD3 Complex; Cells, Cultured; Enzyme Activation; Humans; Immunologic Memory; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase

1999
Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging.
    Mechanisms of ageing and development, 2000, Feb-07, Volume: 113, Issue:2

    Topics: Aging; Animals; Calcimycin; Enzyme Activation; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Lymphocytes; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Phosphorylation; Proteins; Rats; Rats, Inbred F344; Signal Transduction; Spleen; Tetradecanoylphorbol Acetate; Transcription Factors; Tyrosine

2000
Tissue-specific regulation of IRS-2/PI 3-kinase association in aged rats.
    Biological chemistry, 2000, Volume: 381, Issue:1

    Topics: Aging; Animals; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Rats; Signal Transduction; Tyrosine

2000
Is nitrotyrosine generated in human erythrocytes in circulation?
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:4

    Topics: Aging; Animals; Antibodies; Erythrocyte Membrane; Erythrocytes; Hemoglobins; Humans; Membrane Proteins; Rabbits; Ribonuclease, Pancreatic; Tyrosine

2000
Age-related changes in microtubules in the guinea pig organ of Corti. Tubulin isoform shifts with increasing age suggest changes in micromechanical properties of the sensory epithelium.
    Cell and tissue research, 2000, Volume: 300, Issue:1

    Topics: Acetylation; Aging; Animals; Deafness; Female; Guinea Pigs; Immunohistochemistry; Mechanoreceptors; Microscopy, Fluorescence; Microtubules; Organ of Corti; Protein Processing, Post-Translational; Tubulin; Tyrosine

2000
Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
    Neuroscience letters, 1999, Jul-02, Volume: 269, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Female; Humans; Male; Middle Aged; Tyrosine

1999
Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4.
    Molecular and cellular biochemistry, 2000, Volume: 206, Issue:1-2

    Topics: Adipocytes; Aging; Animals; Electrophoresis, Polyacrylamide Gel; Glucose; Glucose Transporter Type 4; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Monosaccharide Transport Proteins; Muscle Proteins; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; Signal Transduction; Tyrosine; Vanadates

2000
Hepatic growth hormone signaling in the late gestation fetal rat.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Aging; Animals; Cells, Cultured; DNA-Binding Proteins; Fetus; Gestational Age; Growth Hormone; Human Growth Hormone; Humans; Injections, Intraperitoneal; Liver; Phosphorylation; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Somatotropin; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Tyrosine

2000
Noninvasive assessment of aromatic L-amino acid decarboxylase activity in aging rhesus monkey brain in vivo.
    Synapse (New York, N.Y.), 2001, Volume: 39, Issue:1

    Topics: Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Dihydroxyphenylalanine; Macaca mulatta; Male; Neurons; Tomography, Emission-Computed; Tyrosine

2001
Enhanced peroxynitrite formation is associated with vascular aging.
    The Journal of experimental medicine, 2000, Dec-18, Volume: 192, Issue:12

    Topics: Acetylcholine; Aging; Animals; Aorta; Body Weight; Calcimycin; Cellular Senescence; Endothelium, Vascular; Enzyme Induction; Hemodynamics; Male; Microscopy, Immunoelectron; Mitochondria; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxidative Stress; Rats; Rats, Inbred Strains; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation

2000
Oxidative-stress-dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats.
    Journal of neurochemistry, 2001, Volume: 76, Issue:4

    Topics: Aging; Animals; Blotting, Western; Central Nervous System; Cerebellum; Cyclic N-Oxides; Free Radical Scavengers; Hippocampus; Immunohistochemistry; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxygen; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Tyrosine; Up-Regulation

2001
Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis.
    Biology of reproduction, 2001, Volume: 64, Issue:3

    Topics: Aging; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Collagen; Cysteine Endopeptidases; DNA Fragmentation; Gene Expression Regulation, Enzymologic; Image Processing, Computer-Assisted; In Situ Nick-End Labeling; Male; Multienzyme Complexes; Muscle, Smooth; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penis; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tyrosine; Ubiquitins

2001
Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain.
    Experimental gerontology, 2001, Volume: 36, Issue:2

    Topics: Aging; Animals; Brain; Lipid Peroxidation; Male; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Sulfhydryl Compounds; Tyrosine

2001
Expression of Ly49E and CD94/NKG2 on fetal and adult NK cells.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Apr-01, Volume: 166, Issue:7

    Topics: Aging; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Ly; beta 2-Microglobulin; Cell Differentiation; Cytotoxicity Tests, Immunologic; Fetus; Immunologic Memory; Killer Cells, Natural; Lectins, C-Type; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NK Cell Lectin-Like Receptor Subfamily A; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Phosphorylation; Rats; Rats, Inbred F344; Receptors, Immunologic; Receptors, KIR; Receptors, Natural Killer Cell; Receptors, NK Cell Lectin-Like; Spleen; T-Lymphocyte Subsets; Thymus Gland; Tumor Cells, Cultured; Tyrosine

2001
PTH stimulates PLCbeta and PLCgamma isoenzymes in rat enterocytes: influence of ageing.
    Cellular signalling, 2001, Volume: 13, Issue:2

    Topics: Aging; Animals; Benzoquinones; Blotting, Western; Cells, Cultured; Duodenum; Electrophoresis, Polyacrylamide Gel; Enterocytes; Genistein; Inositol Phosphates; Isoenzymes; Lactams, Macrocyclic; Male; Parathyroid Hormone; Phospholipase C beta; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Isoforms; Proto-Oncogene Proteins pp60(c-src); Quinones; Rats; Rats, Wistar; Rifabutin; Subcellular Fractions; Time Factors; Type C Phospholipases; Tyrosine

2001
Developmental changes in cerebrospinal fluid concentrations of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy.
    Journal of child neurology, 2001, Volume: 16, Issue:2

    Topics: Adolescent; Age Factors; Aging; Biogenic Monoamines; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Myoclonic Epilepsies, Progressive; Tryptophan; Tyrosine

2001
Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function.
    Neuroendocrinology, 2001, Volume: 74, Issue:1

    Topics: Aging; Animals; Apoptosis; Biomarkers; Gonadotropin-Releasing Hormone; Hypothalamus; Immunohistochemistry; In Situ Nick-End Labeling; Male; Microscopy, Fluorescence; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxytocin; Rats; Rats, Inbred BN; Reproduction; Tyrosine

2001
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
    Neuroscience, 2001, Volume: 104, Issue:3

    Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine

2001
Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats.
    Free radical biology & medicine, 2001, Jul-15, Volume: 31, Issue:2

    Topics: Aging; Animals; Brain; Energy Metabolism; Female; Free Radicals; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Oxidative Phosphorylation; Proteins; Rats; Rats, Wistar; Tyrosine

2001
Cyclodextrin modulation of T lymphocyte signal transduction with aging.
    Mechanisms of ageing and development, 2001, Sep-15, Volume: 122, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Aging; beta-Cyclodextrins; Cell Division; Cell Membrane; Cells, Cultured; Cholesterol; Cyclodextrins; DNA-Binding Proteins; Enzyme Activation; Female; Humans; Janus Kinase 3; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine

2001
Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia.
    Journal of neurochemistry, 2001, Volume: 78, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain Chemistry; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Fever; Homovanillic Acid; Male; Methamphetamine; Nitrates; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine

2001
Hyperthermia induces gene expression of heat shock protein 70 and phosphorylation of mitogen activated protein kinases in the rat cerebellum.
    Neuroscience letters, 2001, Oct-19, Volume: 312, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cerebellum; ErbB Receptors; Fever; Gene Expression Regulation, Enzymologic; HSP70 Heat-Shock Proteins; Hyperthermia, Induced; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA, Messenger; Stress, Physiological; Tyrosine

2001
Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells.
    Spine, 2001, Nov-15, Volume: 26, Issue:22

    Topics: Aging; Animals; Cells, Cultured; Collagen Type II; Collagen Type XI; Gene Expression; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Intervertebral Disc; Male; Phosphoproteins; Phosphorylation; Proteoglycans; Rats; Rats, Wistar; Receptor, IGF Type 1; Sacrococcygeal Region; Tyrosine

2001
The nitrite/collagen reaction: non-enzymatic nitration as a model system for age-related damage.
    Connective tissue research, 2001, Volume: 42, Issue:2

    Topics: Aging; Collagen Type I; Humans; Nitrates; Nitrogen; Tyrosine

2001
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents.
    Neuroscience, 2001, Volume: 107, Issue:3

    Topics: Aging; Animals; Behavior, Animal; DNA, Mitochondrial; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hippocampus; Learning Disabilities; Male; Neurons; Nucleic Acids; Oxidation-Reduction; Oxidative Stress; Rats; RNA, Messenger; Space Perception; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine

2001
Effect of age and oxidative stress on tyrosine phosphorylation of ZAP-70.
    Mechanisms of ageing and development, 2002, Volume: 123, Issue:4

    Topics: Adult; Aged; Aging; Antibodies, Monoclonal; CD3 Complex; Cells, Cultured; Humans; Oxidative Phosphorylation; Oxidative Stress; Protein-Tyrosine Kinases; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase

2002
Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets.
    Mechanisms of ageing and development, 2002, Volume: 123, Issue:4

    Topics: Adult; Aged; Aging; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Female; Humans; Interferon-gamma; Interleukin-2; Ionomycin; Lectins, C-Type; Lymphocyte Activation; Lymphocyte Count; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine

2002
Plasma protein oxidation is associated with an increase of procoagulant markers causing an imbalance between pro- and anticoagulant pathways in healthy subjects.
    Thrombosis and haemostasis, 2002, Volume: 87, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Blood Proteins; Child; Child, Preschool; Female; Fibrinopeptide A; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Prothrombin; Reference Values; Thrombomodulin; Tyrosine; Vitamin E; von Willebrand Factor

2002
Age-related changes in the distribution of nitrotyrosine in the cerebral cortex and hippocampus of rats.
    Brain research, 2002, Mar-29, Volume: 931, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; Hippocampus; Image Processing, Computer-Assisted; Interneurons; Oxidative Stress; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tyrosine

2002
Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-15, Volume: 22, Issue:10

    Topics: Aging; Amidines; Animals; Animals, Newborn; Apoptosis; Benzylamines; Cell Count; Crosses, Genetic; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Proteins; Retina; Retinal Diseases; Retinal Vein Occlusion; Tyrosine

2002
Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.
    Biochemical and biophysical research communications, 2002, May-31, Volume: 294, Issue:1

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Aging; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; CHO Cells; Cloning, Molecular; Cricetinae; Female; Humans; Insulin; Isoenzymes; Male; Mice; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Sequence Alignment; Spermatogenesis; src-Family Kinases; Testis; Tyrosine; Vanadates

2002
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
    Circulation research, 2002, Jun-14, Volume: 90, Issue:11

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aging; Animals; Arginine; Arterioles; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Immunohistochemistry; In Vitro Techniques; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tyrosine; Vasodilation; Xanthine Oxidase

2002
Transfer RNA in aging Drosophila: II. Isoacceptor patterns.
    Mechanisms of ageing and development, 1979, Volume: 10, Issue:1-2

    Topics: Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Asparagine; Drosophila melanogaster; Histidine; Leucine; Male; RNA, Transfer; Tyrosine

1979
[Changes of various biochemical indicators in osteochondrosis in relation to age].
    Ortopediia travmatologiia i protezirovanie, 1976, Issue:3

    Topics: Adolescent; Adult; Aging; Blood Proteins; Glycosaminoglycans; Hexosamines; Humans; Hydroxyproline; Intervertebral Disc; Middle Aged; Osteochondritis; Sialic Acids; Tyrosine

1976
The content of dityrosine in chick and rabbit aorta proteins.
    Connective tissue research, 1979, Volume: 6, Issue:4

    Topics: Aging; Amino Acids; Animals; Aorta; Chemical Phenomena; Chemistry; Elastin; Female; Glycoproteins; Pregnancy; Rabbits; Tyrosine

1979
Age related changes in hormone binding by target cells and tissues; possible role in altered adaptive responsiveness.
    Experimental gerontology, 1975, Volume: 10, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Aging; Animals; Aorta; Child; Female; Glucocorticoids; Glucose; Gonadal Steroid Hormones; Hormones; Humans; Hydrocortisone; Insulin; Insulin Secretion; Isoproterenol; Lipid Metabolism; Male; Middle Aged; Receptors, Cell Surface; Salivary Glands; Thyroid Hormones; Tyrosine; Tyrosine Transaminase

1975
Age related changes in the effect of electroconvulsive shock (ECS) on the in vivo hydroxylation of tyrosine and tryptophan in rat brain.
    Brain research, 1977, Aug-12, Volume: 131, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benzyl Alcohols; Brain; Dihydroxyphenylalanine; Electroshock; Hydrazines; Male; Rats; Tryptophan; Tyrosine

1977
Lipid pigment formation in cultures of chick hepatocytes. Effects of aging and of oxidizable agents.
    Virchows Archiv. B, Cell pathology, 1977, Jan-20, Volume: 23, Issue:1

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Chick Embryo; Iron; Lipid Metabolism; Lipofuscin; Liver; Oxidation-Reduction; Pigments, Biological; Tyrosine

1977
Polyphenol oxidase as a factor in aging.
    Gerontology, 1977, Volume: 23, Issue:5

    Topics: Aging; Animals; Catechol Oxidase; Mathematics; Plants; Proteins; Tyrosine

1977
Compartments of protein metabolism in the developing brain.
    Biochimica et biophysica acta, 1979, Feb-27, Volume: 561, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Kinetics; Mathematics; Mice; Nerve Tissue Proteins; Rats; Species Specificity; Tyrosine

1979
[Senile liver and its repercussions on cerebral activity].
    Minerva medica, 1979, Sep-22, Volume: 70, Issue:40

    Topics: Aged; Aging; Amino Acids; Brain; Cystine; Glutamates; Histidine; Humans; Liver; Serine; Threonine; Tyrosine

1979
Induced PKU in rats: effects of age and melatonin treatment.
    Pharmacology, biochemistry, and behavior, 1977, Volume: 7, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Female; Humans; Learning; Melatonin; Phenylalanine; Phenylketonurias; Pregnancy; Rats; Time Factors; Tyrosine

1977
Catecholamine synthesis in brain of ageing rat.
    Journal of neurochemistry, 1978, Volume: 30, Issue:6

    Topics: Aging; Animals; Brain; Catecholamines; Male; Rats; Tyrosine

1978
Modification of the C-terminus of brain tubulin during development.
    Biochemical and biophysical research communications, 1978, Jul-28, Volume: 83, Issue:2

    Topics: Aging; Amino Acids; Animals; Brain; Carboxypeptidases; Chickens; Glycoproteins; Kinetics; Tubulin; Tyrosine

1978
Post-natal changes in the transport of aromatic amino acids into the brain [proceedings].
    The Journal of physiology, 1978, Volume: 284

    Topics: Aging; Amino Acids; Animals; Biological Transport; Brain; Phenylalanine; Rats; Tryptophan; Tyrosine

1978
Age-dependent changes in central dopaminergic and other monoaminergic systems.
    Advances in experimental medicine and biology, 1978, Volume: 113

    Topics: Aging; Animals; Avoidance Learning; Biogenic Amines; Castration; Child; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Neurons; Penfluridol; Pimozide; Rats; Receptors, Dopamine; Tyrosine

1978
Testing the protein error hypothesis of ageing in Drosophila.
    Experimental gerontology, 1976, Volume: 11, Issue:3-4

    Topics: Aging; Animals; Drosophila melanogaster; Ethionine; Half-Life; Male; Phenylalanine; Proteins; Tryptophan; Tyrosine

1976
Age-related changes in protein turnover and ribonucleic acid of the diaphragm muscle of normal and dystrophic hamsters.
    The Biochemical journal, 1977, Jan-15, Volume: 162, Issue:1

    Topics: Aging; Animals; Cricetinae; Diaphragm; Muscle Proteins; Muscles; Muscular Dystrophy, Animal; RNA; Tyrosine

1977
Tryptophan and 5-hydroxytryptamine metabolism in the immature rat brain during recovery from asphyxia.
    Journal of neurochemistry, 1977, Volume: 28, Issue:3

    Topics: Aging; Animals; Asphyxia; Blood Proteins; Brain; Brain Chemistry; Female; Hydroxyindoleacetic Acid; Male; Protein Binding; Rats; Serotonin; Tryptophan; Tyrosine

1977
Reinstatement of vaginal cycles in aged female rats.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:2

    Topics: Aging; Animals; Benserazide; Carbidopa; Dose-Response Relationship, Drug; Drug Interactions; Estrus; Female; Fusaric Acid; Hypophysectomy; Levodopa; Phenoxybenzamine; Pimozide; Pregnancy; Propranolol; Rats; Tyrosine; Vagina

1976
Blood-brain barrier: selective changes during maturation.
    Neuroscience, 1976, Volume: 1, Issue:2

    Topics: Aging; Animals; Blood-Brain Barrier; Cerebellum; Cerebral Cortex; Chick Embryo; Chickens; Glucose; Inulin; Proline; Structure-Activity Relationship; Tectum Mesencephali; Tyrosine

1976
Aging and the passage of L-tyrosine, L-DOPA, and inulin into mouse brain slices in vitro.
    Journal of gerontology, 1975, Volume: 30, Issue:1

    Topics: Aging; Animals; Biological Transport, Active; Brain; Brain Stem; Corpus Striatum; Hypothalamus; In Vitro Techniques; Inulin; Levodopa; Male; Mice; Mice, Inbred C57BL; Tritium; Tyrosine

1975
An enzyme tyrosylating alpha-tubulin and its role in microtubule assembly.
    Biochemical and biophysical research communications, 1975, Aug-04, Volume: 65, Issue:3

    Topics: Aging; Animals; Brain; Cattle; Colchicine; Kinetics; Ligases; Microtubules; Nerve Tissue Proteins; Rats; Receptors, Drug; Species Specificity; Time Factors; Tubulin; Tyrosine

1975
Ageing and dopamine uptake by subcellular fractions of the C57BL/6J male mouse brain.
    Brain research, 1975, Jun-27, Volume: 91, Issue:2

    Topics: Aging; Animals; Corpus Striatum; Dopamine; Hypothalamus; Kinetics; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Serotonin; Synaptosomes; Tyrosine

1975
Pyridoxal-5-phosphate levels in rat brain assayed by a modified method using enzymic decarboxylation of L-[14C]tyrosine.
    Journal of neurochemistry, 1976, Volume: 26, Issue:2

    Topics: Aging; Animals; Brain; Brain Chemistry; Kinetics; Methods; Microchemistry; Pyridoxal Phosphate; Rats; Tyrosine; Tyrosine Decarboxylase; Vitamin B 6 Deficiency

1976
Defects of insulin's signal transduction in old rat livers.
    Endocrinology, 1992, Volume: 130, Issue:3

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Female; Glucose; Immunoblotting; Injections, Intravenous; Insulin; Insulin Resistance; Liver; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Signal Transduction; Time Factors; Tyrosine

1992
Dopaminergic neuron development in rats: biochemical study from prenatal life to adulthood.
    Brain research bulletin, 1992, Volume: 29, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Female; Hydroxyindoleacetic Acid; Mesencephalon; Nerve Tissue Proteins; Nervous System; Neurons; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Serotonin; Tyrosine

1992
Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice.
    Journal of gerontology, 1992, Volume: 47, Issue:5

    Topics: Aging; Animals; Antibodies; Autoradiography; Blotting, Western; Concanavalin A; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; T-Lymphocytes; Time Factors; Tyrosine

1992
Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1.
    Journal of gerontology, 1992, Volume: 47, Issue:5

    Topics: Aging; Animals; Diaphragm; Diet; Insulin-Like Growth Factor I; Liver; Male; Mice; Mice, Inbred C57BL; Myocardium; Phenylalanine; Protein Biosynthesis; Specific Pathogen-Free Organisms; Time Factors; Tissue Distribution; Tyrosine

1992
o-Tyrosine and dityrosine concentrations in oxidized proteins and lens proteins with age.
    Annals of the New York Academy of Sciences, 1992, Nov-21, Volume: 663

    Topics: Aging; Eye Proteins; Humans; Lens, Crystalline; Oxidation-Reduction; Tyrosine

1992
Morphological and biochemical changes in gastric mucosa of aging rats.
    Digestive diseases and sciences, 1990, Volume: 35, Issue:11

    Topics: Aging; Animals; Atrophy; Blotting, Western; Collagen; Gastric Mucosa; Male; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Tyrosine

1990
[Age changes in concentrations of monoamines and related substances in the cerebrospinal fluid].
    No to shinkei = Brain and nerve, 1991, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Biogenic Monoamines; Child; Chromatography, High Pressure Liquid; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Neurotransmitter Agents; Norepinephrine; Tryptophan; Tyrosine

1991
Signal transduction in human B cells during aging: alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness.
    Lymphokine and cytokine research, 1991, Volume: 10, Issue:6

    Topics: Aging; Amino Acids; B-Lymphocytes; Calcium; Cell Division; Cells, Cultured; Cytosol; Humans; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Ribonucleases; Serine; Signal Transduction; Threonine; Tyrosine

1991
Delayed plasma clearance of phenylalanine and tyrosine in elderly men.
    Journal of the American Geriatrics Society, 1991, Volume: 39, Issue:1

    Topics: Adult; Aged; Aging; Amino Acids; Dementia; Enteral Nutrition; Humans; Middle Aged; Phenylalanine; Tyrosine

1991
Effects of hypothyroidism on the detyrosylation of alpha-tubulin in the parallel fibers of the developing rat cerebellar cortex.
    Developmental neuroscience, 1991, Volume: 13, Issue:2

    Topics: Aging; Animals; Antibodies, Monoclonal; Cerebellar Cortex; Hypothyroidism; Immunohistochemistry; Neurons; Rats; Rats, Inbred Strains; Synapses; Thyroxine; Tubulin; Tyrosine

1991
Neuronal tyrosine phosphorylation in growth cone glycoproteins.
    The Journal of biological chemistry, 1990, Feb-15, Volume: 265, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Axons; Brain; Cell Membrane; Glycoproteins; Growth Substances; Kinetics; Molecular Weight; Phosphorylation; Protein-Tyrosine Kinases; Rats; Substrate Specificity; Tyrosine

1990
Regional distribution of 3-O-methyl-DOPA in the cortex and subcortical structures in the rat: effect of aging.
    Neuroscience letters, 1990, May-04, Volume: 112, Issue:2-3

    Topics: Aging; Animals; Brain; Cerebral Cortex; Male; Rats; Rats, Inbred Strains; Tyrosine

1990
Intestinal transport during the life span of the mouse.
    Journal of gerontology, 1990, Volume: 45, Issue:4

    Topics: 3-O-Methylglucose; Aging; Animals; Biological Transport; Glucose; Intestinal Absorption; Intestine, Small; Male; Methylglucosides; Methylglycosides; Mice; Mice, Inbred C57BL; Tyrosine

1990
Effects of aging and xerosis on the amino acid composition of human skin.
    The Journal of investigative dermatology, 1990, Volume: 95, Issue:3

    Topics: Aging; Amino Acids; Female; Filaggrin Proteins; Glycine; Humans; Ichthyosis; Leucine; Phenylalanine; Skin; Tyrosine

1990
Tyrosine phosphorylation in the postnatal rat brain: a developmental, immunohistochemical study.
    The Journal of comparative neurology, 1989, Apr-01, Volume: 282, Issue:1

    Topics: Aging; Animals; Brain Stem; Cerebellum; Immunohistochemistry; Olfactory Bulb; Phosphorylation; Rats; Rats, Inbred Strains; Tyrosine

1989
Postnatal development of the innervation and paraganglia in the porcine pulmonary arterial bed.
    The Journal of pathology, 1988, Volume: 154, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Intermediate Filaments; Neuropeptides; Paraganglia, Nonchromaffin; Pulmonary Artery; Swine; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin Thiolesterase

1988
Relationship between the tyrosination state of tubulin and the activities of tubulin:tyrosine ligase and tubulin carboxypeptidase in rat muscle during development.
    European journal of biochemistry, 1988, Nov-15, Volume: 177, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Carboxypeptidases; Kinetics; Muscle Development; Muscles; Peptide Synthases; Protein Processing, Post-Translational; Rats; Tubulin; Tyrosine

1988
Fidelity of aminoacylation by rat-liver tyrosyl-tRNA synthetase. Effect of age.
    European journal of biochemistry, 1988, Dec-15, Volume: 178, Issue:2

    Topics: Acylation; Age Factors; Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Binding Sites; Binding, Competitive; Biological Transport; Electrophoresis, Polyacrylamide Gel; Liver; Male; Phenylalanine; Protein Biosynthesis; Rats; Rats, Inbred F344; RNA, Transfer; Tyrosine; Tyrosine-tRNA Ligase

1988
Raman spectroscopic evaluation of aging and long-wave UV exposure in the guinea pig lens: a possible model for human aging.
    Experimental eye research, 1988, Volume: 46, Issue:2

    Topics: Aging; Animals; Disulfides; Guinea Pigs; Lens, Crystalline; Phenylalanine; Protein Conformation; Spectrum Analysis, Raman; Sulfhydryl Compounds; Tryptophan; Tyrosine; Ultraviolet Rays

1988
Effect of aging on intestinal absorption of aromatic amino acids in vitro in the rat.
    The American journal of physiology, 1988, Volume: 254, Issue:4 Pt 1

    Topics: Aging; Animals; In Vitro Techniques; Intestinal Absorption; Jejunum; Kinetics; Male; Phenylalanine; Rats; Rats, Inbred F344; Tryptophan; Tyrosine

1988
Developmental studies on the uptake of tyrosine by synaptosomes and plasma membrane vesicles derived from rat brain. Effect of thyroid hormones.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1986, Volume: 4, Issue:1

    Topics: Aging; Animals; Biological Transport, Active; Brain; Rats; Rats, Inbred Strains; Sodium; Subcellular Fractions; Synaptosomes; Triiodothyronine; Tyrosine

1986
Distribution of aromatic and fluorescent compounds within single human lenses.
    Experimental eye research, 1987, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Fluorescence; Humans; Lens, Crystalline; Middle Aged; Tryptophan; Tyrosine; Uric Acid

1987
Sclerotization of mosquito cuticle.
    Experientia, 1987, Feb-15, Volume: 43, Issue:2

    Topics: Aedes; Aging; Animals; Anopheles; Culex; Pupa; Species Specificity; Tyrosine

1987
The effect of sympathectomy upon iris tyrosinase activity.
    Vision research, 1985, Volume: 25, Issue:2

    Topics: Aging; Animals; Catechol Oxidase; Iris; Monophenol Monooxygenase; Pigment Epithelium of Eye; Rabbits; Sympathectomy; Tyrosine

1985
[Quantitative cytochemistry of the inner ear of the young and senile guinea pig].
    Acta oto-laryngologica. Supplementum, 1970, Volume: 278

    Topics: Aging; Animals; Ear, Inner; Guinea Pigs; Histocytochemistry; Microscopy; Organ of Corti; Photometry; Proteins; RNA; Staining and Labeling; Tritium; Tryptophan; Tyrosine; Ultraviolet Rays

1970
Nutrient transfer during the reproductive cycle in Glossina austeni Newst.: histology and histochemistry of the milk gland, fat body, and oenocytes.
    Tissue & cell, 1973, Volume: 5, Issue:4

    Topics: Adipose Tissue; Aging; Animals; Female; Genitalia, Female; Histocytochemistry; Larva; Milk Proteins; Peroxidases; Pregnancy; Reproduction; Staining and Labeling; Tsetse Flies; Tyrosine

1973
Amyloid in normal and pathological parathyroid glands.
    Journal of clinical pathology, 1974, Volume: 27, Issue:8

    Topics: Aging; Amyloid; Amyloidosis; Autopsy; Histocytochemistry; Humans; Parathyroid Glands; Staining and Labeling; Thyroidectomy; Tryptophan; Tyrosine

1974
Proteolytic activity in muscles of old animals.
    Physiologia Bohemoslovaca, 1965, Volume: 14, Issue:5

    Topics: Aging; Animals; Female; Muscle Denervation; Muscle Proteins; Muscles; Peptide Hydrolases; Rats; Serum Albumin; Serum Globulins; Spectrophotometry; Subcellular Fractions; Tyrosine

1965
Adrenergic neurohumors in the heart of hamsters with hereditary myopathy during cardiac hypertrophy and failure.
    Recent advances in studies on cardiac structure and metabolism, 1972, Volume: 1

    Topics: Aging; Animals; Cardiomegaly; Cricetinae; Dopamine; Heart; Heart Failure; Myocardial Contraction; Myocardium; Norepinephrine; Organ Size; Tyrosine

1972
Activity of the phenylalanine hydroxylating system in liver of newborn, suckling and adult rats.
    Acta biochimica Polonica, 1969, Volume: 16, Issue:4

    Topics: Aging; Aldehydes; Animals; Animals, Newborn; Body Weight; Carbon Isotopes; Female; Kinetics; Liver; Male; Mixed Function Oxygenases; NAD; Organ Size; Phenylalanine; Proteins; Rats; Tyrosine

1969
Ontogeny of soluble and mitochondrial tyrosine aminotransferases.
    Science (New York, N.Y.), 1969, Mar-21, Volume: 163, Issue:3873

    Topics: Aging; Animals; Animals, Newborn; Biological Evolution; Female; Fetus; Haplorhini; Mitochondria, Liver; Pregnancy; Tyrosine; Tyrosine Transaminase

1969
Aromatic amino acid metabolism in the wabbler-lethal mouse.
    Biochemical genetics, 1969, Volume: 2, Issue:4

    Topics: Aging; Animals; Liver; Mice; Mixed Function Oxygenases; Nervous System Diseases; Phenylalanine; Rodent Diseases; Transaminases; Tryptophan; Tryptophan Oxygenase; Tyrosine; Tyrosine Transaminase

1969
Plasma tryptophan and 5-HT metabolism in the CNS of the newborn rat.
    Journal of neurochemistry, 1974, Volume: 23, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Blood-Brain Barrier; Brain; Brain Stem; Chlordiazepoxide; Chromatography, Gel; Chromatography, Ion Exchange; Female; Hydroxyindoleacetic Acid; In Vitro Techniques; Kinetics; Male; Organ Specificity; Pregnancy; Rats; Salicylates; Serotonin; Time Factors; Tritium; Tryptophan; Tyrosine; Ultrafiltration

1974
Disappearance of tyrosine residues in collagen with age. Suggestion of a possible reaction mechanism.
    Experimental gerontology, 1974, Volume: 9, Issue:3

    Topics: Achilles Tendon; Aging; Amino Acids; Aniline Compounds; Animals; Anisoles; Biphenyl Compounds; Cattle; Collagen; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Nitrates; Nitrobenzenes; Oxidation-Reduction; Pronase; Rats; Solubility; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Tail; Temperature; Tendons; Tyrosine

1974
Age-associated changes of an amyloid related serum component.
    Transactions of the Association of American Physicians, 1974, Volume: 87

    Topics: Acute Disease; Adolescent; Adult; Aged; Aging; Amyloid; Amyloidosis; Arteriosclerosis; Child; Child, Preschool; Chromatography, Gel; Chronic Disease; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Iodine Radioisotopes; Middle Aged; Osteoarthritis; Pregnancy; Radioimmunoassay; Tyrosine

1974
Neonatal 6-hydroxydopamine treatment: noradrenaline levels and in vitro 3H-catecholamine synthesis in discrete brain regions of adult rats.
    Life sciences, 1974, Dec-15, Volume: 15, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Brain; Catecholamines; Chromatography; Dopamine; Drug Administration Schedule; Hydroxydopamines; Male; Norepinephrine; Rats; Rats, Inbred Strains; Tyrosine

1974
Occurrence and distribution of aromatic L-amino acid (L-DOPA) decarboxylase in the human brain.
    Journal of neurochemistry, 1972, Volume: 19, Issue:6

    Topics: 5-Hydroxytryptophan; Aged; Aging; Animals; Basal Ganglia; Brain; Carbon Isotopes; Cats; Cattle; Caudate Nucleus; Cerebral Cortex; Chromatography, Paper; Diencephalon; Dopa Decarboxylase; Enzyme Activation; Female; Haplorhini; Humans; Hypothalamus; Male; Mesencephalon; Middle Aged; Pineal Gland; Pyridoxal Phosphate; Rats; Species Specificity; Stereoisomerism; Tyrosine

1972
Catecholamine metabolism in the brains of ageing male mice.
    Brain research, 1973, Mar-30, Volume: 52

    Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Corpus Striatum; Dihydroxyphenylalanine; DNA; Dopa Decarboxylase; Dopamine; Fluorometry; Hypothalamus; Male; Mice; Norepinephrine; Organ Size; Tritium; Tyrosine

1973
Relationship of protein metabolism to senescence of corn (Zea mays L.) stalk parenchyma, cob parenchyma and first developed leaf tissues.
    Mechanisms of ageing and development, 1973, Volume: 1, Issue:5

    Topics: Aging; Alanine; Amino Acids; Aspartic Acid; Carbon Isotopes; Cell Count; Chromatography; Dactinomycin; Glutamine; Leucine; Models, Biological; Ornithine; Phenylalanine; Plant Proteins; Plants; Ribonucleases; Ribosomes; RNA; RNA, Messenger; Threonine; Time Factors; Tyrosine

1973
Uncorporation of phenylalanine as a single unit into rat brain protein: reciprocal inhibition by phenylalanine and tyrosine of their respective incorporations.
    Journal of neurochemistry, 1973, Volume: 21, Issue:5

    Topics: Adenosine Triphosphate; Aging; Animals; Asparagine; Brain; Carbon Radioisotopes; Glutamates; Glutamine; Histidine; In Vitro Techniques; Kidney; Kinetics; Liver; Magnesium; Methionine; Nerve Tissue Proteins; Phenylalanine; Potassium; Rats; Thyroid Gland; Tritium; Tryptophan; Tyrosine

1973
Some biochemical and histochemical properties of the age pigment in the human intervertebral disc.
    Histochemie. Histochemistry. Histochimie, 1973, Oct-26, Volume: 37, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Chromatography, Thin Layer; Histocytochemistry; Humans; Intervertebral Disc; Lipids; Microchemistry; Middle Aged; Pigments, Biological; Triglycerides; Tyrosine

1973
Lipid metabolism in liver and brain in acute hyperphenylalaninemia in rats of different ages. Correlation with tissue phenylalanine and tyrosine levels.
    Biology of the neonate, 1974, Volume: 24, Issue:3

    Topics: Acetates; Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Cholesterol; Chromatography, Thin Layer; Female; Glycolipids; Lipid Metabolism; Liver; Phenylalanine; Phenylalanine Hydroxylase; Phospholipids; Rats; Time Factors; Tyrosine

1974
Free amino acids in developing rat retina.
    Journal of neurochemistry, 1974, Volume: 22, Issue:6

    Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Differentiation; Chromatography, Ion Exchange; Glutamates; Glutamine; Glycine; Histidine; Methionine; Ornithine; Proline; Rats; Retina; Taurine; Time Factors; Tyrosine

1974
Arterial mesenchyme and arteriosclerosis. Enzymic vs non-enzymic factors in the deterioration of connective tissue.
    Advances in experimental medicine and biology, 1974, Volume: 43, Issue:0

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Animals; Aorta; Arteries; Arteriosclerosis; Blood Platelets; Cattle; Child; Collagen; Connective Tissue; Culture Techniques; Elastic Tissue; Elastin; Female; Fluorescence; Humans; Leukocytes; Male; Middle Aged; Pancreatic Elastase; Phenylalanine; Pregnancy; Proteins; Solubility; Tyrosine; Ultraviolet Rays; X-Ray Diffraction

1974
Amino acid incorporation and aminoacyl transfer in an insect pupal system.
    The Journal of biological chemistry, 1968, Nov-25, Volume: 243, Issue:22

    Topics: Adenosine Triphosphate; Aging; Amino Acids; Animals; Carbon Isotopes; Coleoptera; Escherichia coli; Guanine Nucleotides; Leucine; Liver; Magnesium; Metamorphosis, Biological; Microsomes; Potassium; Puromycin; Rabbits; Ribonucleases; Ribosomes; RNA, Transfer; Tyrosine; Ultracentrifugation

1968
L-tyrosine-3,5-3H assay for tyrosinase development in skin of newborn hamsters.
    Science (New York, N.Y.), 1969, May-16, Volume: 164, Issue:3881

    Topics: Aging; Animals; Animals, Newborn; Catechol Oxidase; Cricetinae; Fetus; Skin; Tritium; Tyrosine

1969
An accurate method of determining age in small mammals.
    Journal of mammalogy, 1972, Volume: 53, Issue:1

    Topics: Aging; Animals; Female; Lens, Crystalline; Male; Mammals; Methods; Mice; Time Factors; Tyrosine

1972
The effect of diet upon the excretion of parahydroxy-phenylacetic acid and creatinine in man.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 40, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aging; Child; Child, Preschool; Creatinine; Diet; Female; Humans; Hydrogen-Ion Concentration; Infant; Male; Middle Aged; Phenols; Phenylacetates; Time Factors; Tyrosine

1972
[Biochemical studies on the age-related variations of the human intervertebral disc].
    Nihon Seikeigeka Gakkai zasshi, 1972, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Chromatography; Collagen; Galactosamine; Glucosamine; Hexosamines; Humans; Infant; Intervertebral Disc; Lumbar Vertebrae; Middle Aged; Phenylalanine; Potassium; Sodium; Thoracic Vertebrae; Tryptophan; Tyrosine

1972
Variations in oral tissues as associated with ageing.
    Archives of oral biology, 1967, Volume: 12, Issue:2

    Topics: Aging; Animals; Gingiva; Guinea Pigs; Hexoses; Histocytochemistry; In Vitro Techniques; Male; Mouth Mucosa; Palate; Tyrosine

1967
[The amino acid composition of human lens proteins in the course of lens alterations and cataract transformation. I. The amino acid composition of unclouded human lenses of various age groups].
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1966, Dec-15, Volume: 171, Issue:3

    Topics: Adult; Age Factors; Aged; Aging; Alanine; Amino Acids; Arginine; Asparagine; Cataract; Crystallins; Glutamates; Glycine; Humans; Isoleucine; Lens, Crystalline; Leucine; Lysine; Middle Aged; Nitrogen; Peptide Hydrolases; Phenylalanine; Tyrosine

1966
Subunit structure of rabbit muscle aldolase: extent of homology of the alpha and beta subunits and age-dependent changes in their ratio.
    Archives of biochemistry and biophysics, 1969, Volume: 134, Issue:2

    Topics: Aging; Amino Acids; Animals; Bromine; Carboxypeptidases; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cyanides; Electrophoresis, Disc; Female; Fructose-Bisphosphate Aldolase; Histidine; Male; Muscles; Peptides; Rabbits; Trypsin; Tyrosine; Urea

1969
Age-dependent changes in the human intervertebral disc. Fluorescent substances and amino acids in the anulus fibrosus.
    Gerontologia, 1970, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Amino Acids; Fluorescence; Glucosamine; Hexosamines; Humans; Hydroxyproline; Intervertebral Disc; Microscopy, Fluorescence; Middle Aged; Spectrophotometry; Tyrosine

1970
Appearance and concentrations of catecholamines and their biosynthesis in the embryonic and developing chick.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 159, Issue:1

    Topics: Aging; Animals; Catecholamines; Chick Embryo; Chickens; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Epinephrine; Mixed Function Oxygenases; Myocardium; Norepinephrine; Transferases; Tritium; Tyrosine

1968
The free amino acids in the haemolymph of the maturing adult boll weevil, Anthonomus grandis Boheman.
    Comparative biochemistry and physiology, 1968, Volume: 25, Issue:1

    Topics: Aging; Amino Acids; Animals; Chromatography; Chromatography, Thin Layer; Coleoptera; Electrophoresis; Female; Hemolymph; Male; Nitrogen; Sex; Tyrosine

1968
Hyperphenylalaninemia: effect on the developing rat brain.
    Canadian journal of biochemistry, 1969, Volume: 47, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Humans; Injections, Subcutaneous; Lipid Metabolism; Liver; Mixed Function Oxygenases; Myelin Sheath; Organ Size; Phenylalanine; Phenylketonurias; Rats; Tyrosine

1969
Proteolytic activity in muscles of old animals.
    Physiologia bohemoslovenica, 1965, Volume: 14, Issue:5

    Topics: Aging; Animals; Female; Muscle Denervation; Muscle Proteins; Muscles; Peptide Hydrolases; Rats; Serum Albumin; Serum Globulins; Spectrophotometry; Subcellular Fractions; Tyrosine

1965
Relationship between age and haemoglobin-splitting activity in chicken muscle.
    Nature, 1966, Jun-18, Volume: 210, Issue:5042

    Topics: Aging; Animals; Cathepsins; Hemoglobins; Muscles; Poultry; Proteins; Tyrosine

1966